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Penicillin allergy

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https://www.readbyqxmd.com/read/29430947/successful-implementation-of-a-simple-algorithm-to-manage-penicillin-allergy-in-an-acute-care-community-hospital
#1
Kwang Yoon, Michelle Lee, Ramesh Patel, Zoon Park
No abstract text is available yet for this article.
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29425903/efficacy-and-safety-of-five-day-challenge-for-the-evaluation-of-non-severe-amoxicillin-allergy-in-children
#2
Roxane Labrosse, Louis Paradis, Jonathan Lacombe, Kathryn Samaan, François Graham, Jean Paradis, Philipps Bégin, Anne Des Roches
BACKGROUND: Penicillin allergy is the most frequent drug allergy, among which aminopenicillins are reputed for causing delayed rashes in children, particularly in the context of viral infections. Despite a negative allergy evaluation, a significant proportion of individuals continue to avoid penicillin antibiotics for fear of an allergic reaction. OBJECTIVES: This study sought to evaluate the safety and efficacy of a five-day challenge to amoxicillin and the proportion of subsequent use of amoxicillin...
February 6, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29413343/clinical-and-economic-burden-of-hospitalizations-with-registration-of-penicillin-allergy
#3
Bernardo Sousa-Pinto, António Cardoso-Fernandes, Luís Araújo, João Almeida Fonseca, Alberto Freitas, Luís Delgado
BACKGROUND: Penicillin allergy is commonly reported, but only a minority of claimants has a confirmed diagnosis. Nevertheless, patients labeled as having penicillin allergy are treated with second-line antibiotics, which are more expensive and less effective, possibly increasing the risk of drug-resistant infections. OBJECTIVE: To compare hospitalizations with and without registration of penicillin allergy concerning their morbidity and hospital resource use. METHODS: We analyzed a national administrative database containing a registration of all Portuguese hospitalizations from 2000 to 2014...
February 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29408440/cross-reactivity-and-tolerability-of-cephalosporins-in-patients-with-ige-mediated-hypersensitivity-to-penicillins
#4
Antonino Romano, Rocco Luigi Valluzzi, Cristiano Caruso, Michela Maggioletti, Donato Quaratino, Francesco Gaeta
BACKGROUND: Studies performed since 1990 on samples of at least 30 subjects with a documented IgE-mediated hypersensitivity to penicillins have found a rate of positive responses to allergy tests with cephalosporins ranging from 0% to 27%. OBJECTIVE: We sought to assess the cross-reactivity with cephalosporins and evaluate the possibility of using cephalosporins in penicillin-allergic subjects. METHOD: We conducted a prospective study of 252 consecutive subjects who had suffered 319 immediate reactions (mostly anaphylaxis) to penicillins and had positive skin tests to at least one penicillin reagent...
February 2, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29395509/exploring-the-nurses-role-in-antibiotic-stewardship-a-multisite-qualitative-study-of-nurses-and-infection-preventionists
#5
Eileen J Carter, William G Greendyke, E Yoko Furuya, Arjun Srinivasan, Alexa N Shelley, Aditi Bothra, Lisa Saiman, Elaine L Larson
BACKGROUND: There is a growing recognition of the need to partner with nurses to promote effective antibiotic stewardship. In this study, we explored the attitudes of nurses and infection preventionists toward 5 nurse-driven antibiotic stewardship practices: 1) questioning the need for urine cultures; 2) ensuring proper culturing technique; 3) recording an accurate penicillin drug allergy history; 4) encouraging the prompt transition from intravenous (IV) to oral (PO) antibiotics; and 5) initiating an antibiotic timeout...
January 30, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29383926/piperacillin-tazobactam-anaphylaxis-a-rare-cause-of-occupational-disease
#6
J Gaspar-Marques, E Finelli, P C Martins, S Prates, P Leiria-Pinto
Piperacillin is a beta-lactam antibiotic of penicillin family. Some penicillins were report-ed as occupational diseases cause, but piperacillin anaphylaxis with occupational sensi-tization is rare. We describe the case of a female nurse with recurrent anaphylaxis in last few months without apparent cause, only in work environment. Latex allergy was excluded after negative latex glove provocation. Later during diagnostic workup, the patient reported a similar reaction minutes after piperacillin preparation. She denied any previous antibiotic therapeutic exposure...
November 20, 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29361016/the-influence-of-reported-penicillin-allergy
#7
E Patchen Dellinger, Rupali Jain, Paul S Pottinger
No abstract text is available yet for this article.
January 18, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29361015/the-impact-of-a-reported-penicillin-allergy-on-surgical-site-infection-risk
#8
Kimberly G Blumenthal, Erin E Ryan, Yu Li, Hang Lee, James L Kuhlen, Erica S Shenoy
Background: A reported penicillin allergy may compromise receipt of recommended antibiotic prophylaxis intended to prevent surgical site infections (SSIs). Most patients with a reported penicillin allergy are not allergic. We determined the impact of a reported penicillin allergy on the development of SSIs. Methods: In this retrospective cohort study of Massachusetts General Hospital hip arthroplasty, knee arthroplasty, hysterectomy, colon surgery, and coronary artery bypass grafting patients from 2010 to 2014, we compared patients with and without a reported penicillin allergy...
January 18, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29355985/identification-of-t-cell-epitopes-from-benzylpenicillin-conjugated-to-human-serum-albumin-and-implication-in-penicillin-allergy
#9
Marie Eliane Azoury, Lucia Filì, Rami Bechara, Noémie Scornet, Luc de Chaisemartin, Richard J Weaver, Nancy Claude, Bernard Maillere, Paola Parronchi, Delphine Joseph, Marc Pallardy
BACKGROUND: There is in vitro evidence that T-cells from allergic patients react to benzylpenicillin-human serum albumin (BP-HSA) bioconjugates. Our group has recently shown the existence of naïve CD4+ T lymphocytes recognizing BP-HSA in healthy donors. However, BP-haptenated peptides from HSA participating in the immunization of allergic patients have never been identified. The purpose of the present study is to identify immunodominant BP-haptenated peptides from HSA involved in immunization of patients to BP and to refine the frequency calculation of naïve CD4+ T-cells recognizing BP...
January 22, 2018: Allergy
https://www.readbyqxmd.com/read/29355644/the-cost-of-self-reported-penicillin-allergy-a-systematic-review
#10
T Joseph Mattingly, Anne Fulton, Rachel A Lumish, Anne M C Williams, SeJeong Yoon, Melissa Yuen, Emily L Heil
BACKGROUND: Patients who report a penicillin (PCN) allergy receive suboptimal antibiotic therapy compared to patients not reporting an allergy. However, a majority of patients who report PCN allergy are not truly allergic upon confirmatory testing. Ruling out PCN allergy by testing may improve clinical and economic outcomes for patients with reported allergies requiring antibiotic therapy. OBJECTIVES: To summarize clinical and economic outcomes associated with PCN allergy and provide recommendations for future cost-effectiveness analyses for PCN allergy testing...
January 17, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29355643/a-penicillin-skin-testing-initiative-in-an-outpatient-allergy-office
#11
Allison Ramsey, S Shahzad Mustafa
No abstract text is available yet for this article.
January 17, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29346543/the-impact-of-reported-beta-lactam-allergy-in-hospitalized-patients-with-hematologic-malignancies-requiring-antibiotics
#12
Kuan-Hsiang Gary Huang, Valerie Cluzet, Keith Hamilton, Olajumoke Fadugba
Background: Patients hospitalized with hematologic malignancy are particularly vulnerable to infection. The impact of reported beta-lactam (BL) allergy in this population remains unknown. Objective: To define the impact of reported BL-only allergy (BLOA) label on clinical outcomes compared to those with no BL allergy (NBLA) in hematologic malignancy inpatients requiring systemic antibiotics. Methods: Retrospective cohort study of adult inpatients with hematologic malignancy admitted at two tertiary care hospitals 2010-2015...
January 16, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29341373/antibiotic-allergy-labels-the-impact-of-taking-a-clinical-history
#13
Adrienne Torda, Victor Chan
BACKGROUND: Many patients admitted to hospital have an antibiotic allergy (AAL) documented in their medical record. In many of these, the reaction is not a hypersensitivity reaction or may no longer be relevant. Despite this, the label adversely affects patient care directly in terms of antibiotic selection, and indirectly in terms of patient costs and the development of antimicrobial resistance. AIMS: To estimate the prevalence of AALs in a cohort of hospitalised patients, to investigate the feasibility of de-labelling through re-challenge based solely upon clinical grounds...
January 17, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29318506/predictors-of-postoperative-urinary-tract-infection-after-bariatric-surgery
#14
Zachary M Helmen, Melissa C Helm, Joseph H Helm, Alexander Nielsen, Tammy Kindel, Rana Higgins, Jon C Gould
BACKGROUND: In bariatric surgery patients, urinary tract infections (UTIs) are one of the most common postoperative infections. In this study, we sought to determine if preoperative patient factors and perioperative processes contribute to an increased risk of UTI. METHODS: A retrospective analysis was performed of patients who underwent bariatric surgery at a single institution between March 2012 and May 2016. Standard protocol was antibiotic prophylaxis with cefazolin...
January 9, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29304914/evaluation-and-management-of-penicillin-allergy
#15
REVIEW
Thanai Pongdee, James T Li
Penicillin allergy is the most commonly reported drug allergy in the United States. Although penicillin allergy is widely reported, 80% to 90% of individuals with self-reported penicillin allergy are actually able to tolerate penicillins after undergoing evaluation for penicillin allergy. Because most patients with self-reported penicillin allergy will have subsequent negative allergy testing results and tolerate penicillins, they may be unnecessarily exposed to broader-spectrum antibiotics. Use of such antibiotics leads to increased risks of developing antibiotic-resistant microorganisms and incur higher health care utilization costs...
January 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29242142/use-of-a-penicillin-allergy-screening-algorithm-and-penicillin-skin-testing-for-transitioning-hospitalized-patients-to-first-line-antibiotic-therapy
#16
Allison Ramsey, Mary L Staicu
BACKGROUND: Penicillin allergy is the most commonly reported antibiotic allergy. Avoidance of β-lactam antibiotics in hospitalized patients leads to the use of second-line therapies. OBJECTIVE: The utility of a penicillin allergy history algorithm (PAHA) and subsequent penicillin skin testing (PST) in transitioning hospitalized patients from second- to first-line antibiotic therapy is described. METHODS: Through an electronic medical record report, pharmacists identified adult inpatients with penicillin allergy receiving moxifloxacin, intravenous vancomycin, aztreonam, daptomycin, or linezolid, in which a β-lactam antibiotic was preferred...
December 11, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29193647/the-incidence-characteristics-managements-and-outcomes-of-anaphylaxis-in-pregnancy-a-population-based-descriptive-study
#17
Stephen J McCall, Kathryn J Bunch, Peter Brocklehurst, Rhiannon D'Arcy, Kim Hinshaw, Jennifer J Kurinczuk, D Nuala Lucas, Benjamin Stenson, Derek Tuffnell, Marian Knight
OBJECTIVE: The aim of this study was to estimate the incidence of anaphylaxis in pregnancy and describe the management and outcomes in the UK. DESIGN: A population based descriptive study using the UK Obstetric Surveillance System(UKOSS). SETTING: All consultant-led maternity units in the UK. POPULATION: All pregnant women who had anaphylaxis between 1st October 2012 and 30th September 2015. Anaphylaxis was defined as a severe, life-threatening generalised or systemic hypersensitivity reaction...
November 29, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29181022/first-line-helicobacter-pylori-eradication-with-vonoprazan-clarithromycin-and-metronidazole-in-patients-allergic-to-penicillin
#18
Soichiro Sue, Nobumi Suzuki, Wataru Shibata, Tomohiko Sasaki, Hiroaki Yamada, Hiroaki Kaneko, Toshihide Tamura, Tomohiro Ishii, Masaaki Kondo, Shin Maeda
Aim: To assess the efficacy of 7-day first-line Helicobacter pylori eradication with vonoprazan (VPZ), clarithromycin (CAM), and metronidazole (MNZ) in patients with penicillin allergy. Methods: Patients with penicillin allergy, diagnosed with Helicobacter pylori infection and did not have history of Helicobacter pylori eradication, were eligible for the study. Twenty patients were prospectively treated with 20 mg VPZ twice daily, 200 or 400 mg CAM twice daily, and 250 mg MNZ twice daily for 7 days...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29177030/is-a-positive-intracutaneous-test-induced-by-penicillin-mediated-by-histamine-a-cutaneous-microdialysis-study-in-penicillin-allergic-patients
#19
Line K Tannert, Sidsel Falkencrone, Charlotte G Mortz, Carsten Bindslev-Jensen, Per Stahl Skov
Background: Diagnostic workup of penicillin allergy comprises skin testing with penicillins, and patients are deemed allergic if skin test is positive. However, the literature suggests that skin test-positive patients may be challenge-negative, indicating that the skin test may be falsely positive. Objective: To investigate real-time histamine release from a positive intracutaneous test induced by penicillin in patients with positive and negative challenges to penicillin...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29114827/persistence-of-penicillin-allergy-reply
#20
LETTER
Jason A Trubiano, N Franklin Adkinson, Elizabeth Jane Phillips
No abstract text is available yet for this article.
November 7, 2017: JAMA: the Journal of the American Medical Association
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