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Penicillin allergy

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https://www.readbyqxmd.com/read/28814358/frequency-of-selective-immediate-responders-to-aminopenicillins-and-cephalosporins-in-turkish-children
#1
Emine Dibek Misirlioglu, Hakan Guvenir, Muge Toyran, Emine Vezir, Murat Capanoglu, Ersoy Civelek, Betul Buyuktiryaki, Tayfur Ginis, Can Naci Kocabas
BACKGROUND: Beta-lactam antibiotics (BLA) are the most commonly prescribed antibiotics and are responsible for the majority of immediate hypersensitivity reactions to drugs in children. Cross-reactivity is important in hypersensitivity to BLAs because these drugs all share a common beta-lactam structure and some share similar side chains. OBJECTIVE: The aim of this study was to evaluate the clinical characteristics of patients who are diagnosed with immediate-type BLA hypersensitivity and frequency of patients with side chain hypersensitivity, "selective responders...
September 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28803185/risk-of-allergic-reactions-to-recurrent-intravenous-penicillin-administration-in-penicillin-skin-test-negative-patients
#2
Steve M Dorman, Sharon Seth, David A Khan
BACKGROUND: Patients with a history of penicillin allergy who are found to be skin test negative to penicillin are able to tolerate repeated oral doses of penicillin with low rates of resensitization. However, the resensitization rate after repeated doses of intravenous penicillin is less clear. OBJECTIVE: We sought to evaluate the risk of allergic reactions to repeated doses of intravenous penicillin in patients who previously reported penicillin allergy and were found to be penicillin skin test and oral challenge negative...
August 9, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28783775/low-grade-fever-erythematous-rash-in-pregnant-woman-%C3%A2-dx
#3
James M O'Brien, Jonathan D Baum
A 31-year-old woman presented to her obstetrician's office at 16 weeks' gestation with a 2-day history of low-grade fever and an erythematous rash measuring 1 x 4 cm on her right groin. She had a medical history of a penicillin allergy (urticarial) and her outdoor activities included gardening and picnicking. What's your diagnosis?
August 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28754406/antibiotic-use-in-2016-by-members-of-the-american-association-of-endodontists-report-of-a-national-survey
#4
Mark Germack, Christine M Sedgley, Wael Sabbah, Brian Whitten
INTRODUCTION: This study surveyed the antibiotic prescribing practices of endodontists, and data were compared with previous surveys conducted in 1994 and 1999. METHODS: A 17-question survey was sent via www.surveymonkey.com to 3000 active members of the American Association of Endodontists for responses about antibiotic prescribing practices and demographics. The data were analyzed using descriptive statistics, chi-square tests, and linear regression analyses...
July 25, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28754229/-hypersensitivity-reactions-to-beta-lactam-antibiotics
#5
E Amsler, A Soria
Allergy to beta-lactam antibiotics is a common condition and about 10% of patients report being allergic to penicillin. However, this diagnosis is largely overestimated. Two types of allergy should be distinguished and include immediate hypersensitivity that can lead to anaphylactic shock and delayed hypersensitivity, ranging from the most common maculopapular exanthema to severe bullous toxidermia or life-threatening DRESS. Allergy challenge with oriented skin tests according to the clinical features, supplemented with oral challenge in the absence of contraindication, will confirm or invalidate the diagnosis of beta-lactam allergy and will help to identify if necessary safe alternatives to beta-lactams...
July 25, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28743423/utility-of-minor-determinants-for-skin-testing-in-inpatient-penicillin-allergy-evaluation
#6
Bob Geng, Jacqueline J Eastman, Karen Mori, Melinda Braskett, Marc A Riedl
BACKGROUND: Most patients with a history of penicillin allergy can tolerate penicillin. Skin testing can identify tolerant patients, but not all known allergenic determinants are commercially available. Protocols exist that use only available reagents, but the sensitivity and safety of these protocols, particularly for hospitalized patients, are controversial. OBJECTIVE: To determine the number of hospitalized patients referred for penicillin skin testing who showed unique positivity to the minor determinants penicilloate and penilloate...
July 22, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28742226/documentation-of-penicillin-adverse-drug-reactions-in-electronic-health-records-inconsistent-use-of-allergy-and-intolerance-labels
#7
Joshua M Inglis, Gillian E Caughey, William Smith, Sepehr Shakib
BACKGROUND: The majority of patients with penicillin allergy labels tolerate penicillins. Inappropriate avoidance of penicillin is associated with increased hospitalisation, infections and healthcare costs. AIMS: To examine the documentation of penicillin adverse drug reactions (ADR) in a large-scale hospital-based electronic health record. METHODS: Penicillin ADRs were extracted from 96,708 patient records in the Enterprise Patient Administration System in South Australia...
July 25, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28724882/using-%C3%AE-lactam-antibiotics-in-patients-with-a-history-of-%C3%AE-lactam-allergy-current-concepts
#8
Esther Moreno, Elena Laffond, Francisco Javier Muñoz-Bellido, María Teresa Gracia, Eva María Macías, Ignacio Dávila
β-lactams are the most widely used antibiotic family, but they are also the most common cause of drug-induced hypersensitivity reactions. The estimated prevalence of reported penicillin allergy ranges between 9% and 12%, although a high percentage of patients with a history of penicillin allergy have no subsequent reactions on reexposure to β-lactams. A self-reported penicillin allergy has been associated with antimicrobial resistance, increased cost, intensive care admission, and death, making it essential to establish an accurate diagnosis...
August 9, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28698037/cefazolin-versus-anti-staphylococcal-penicillins-for-treatment-of-methicillin-susceptible-staphylococcus-aureus-bacteremia-a-narrative-review
#9
REVIEW
Paul Loubet, Charles Burdet, William Vindrios, Nathalie Grall, Michel Wolff, Yazdan Yazdanpanah, Antoine Andremont, Xavier Duval, François-Xavier Lescure
BACKGROUND: Anti-staphylococcal penicillins (ASPs) are recommended as first-line agents in methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. Concerns about the safety profile have contributed to the increased use of cefazolin. The comparative clinical effectiveness and safety profile of cefazolin versus ASPs for such infections remain unclear. Furthermore, uncertainty persists concerning the use of cefazolin due to controversies over its efficacy in deep MSSA infections and its possible negative ecological impact...
July 8, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28674112/allergy-testing-in-children-with-low-risk-penicillin-allergy-symptoms
#10
David Vyles, Juan Adams, Asriani Chiu, Pippa Simpson, Mark Nimmer, David C Brousseau
BACKGROUND: Penicillin allergy is commonly reported in the pediatric emergency department (ED). True penicillin allergy is rare, yet the diagnosis results from the denial of first-line antibiotics. We hypothesize that all children presenting to the pediatric ED with symptoms deemed to be low-risk for immunoglobulin E-mediated hypersensitivity will return negative results for true penicillin allergy. METHODS: Parents of children aged 4 to 18 years old presenting to the pediatric ED with a history of parent-reported penicillin allergy completed an allergy questionnaire...
August 2017: Pediatrics
https://www.readbyqxmd.com/read/28672355/rates-and-consequences-of-false-penicillin-allergies-in-australia
#11
Hannah May Pawlasty, Angus John Thompson, Leanne Chalmers
No abstract text is available yet for this article.
July 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28672303/penicillin-allergy-is-not-necessarily-forever
#12
Jason A Trubiano, N Franklin Adkinson, Elizabeth Jane Phillips
No abstract text is available yet for this article.
July 4, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28658325/comparison-of-efficacy-of-treatments-for-early-syphilis-a-systematic-review-and-network-meta-analysis-of-randomized-controlled-trials-and-observational-studies
#13
Hong-Ye Liu, Yan Han, Xiang-Sheng Chen, Li Bai, Shu-Ping Guo, Li Li, Peng Wu, Yue-Ping Yin
BACKGROUND: Parenteral penicillin is the first-line regimen for treating syphilis, but unsuitable for some patients due to penicillin allergy and lacking health resources. Unfortunately, the efficacy of penicillin alternatives remains poorly understood. This study aimed to assess the efficacy of ceftriaxone and doxycycline/tetracycline in treating early syphilis relative to that of penicillin, and thereby to determine which antibiotic is a better replacement for penicillin. METHOD: By searching literature from PubMed, Cochrane Central Register of Controlled Trials, Embase, the Web of Science, and ClinicalTrials...
2017: PloS One
https://www.readbyqxmd.com/read/28593040/the-impact-of-penicillin-allergy-labels-on-antibiotic-and-health-care-use-in-primary-care-a-retrospective-cohort-study
#14
Tanly Su, Berna D L Broekhuizen, Theo J M Verheij, Heike Rockmann
BACKGROUND: Suspected penicillin allergy (Pen-A) is often not verified by diagnostic testing. In third line penicillin allergy labels were associated with prescription of broad spectrum antibiotics, hospital stay duration and readmission. OBJECTIVE: Assess the impact of Pen-A labels on antibiotic and health care use in primary care. METHODS: A retrospective cohort study was conducted in primary care in the Utrecht area, the Netherlands. All patients registered with a penicillin allergy on 31 December 2013 were selected from the General Practitioner Network database...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28578908/prospective-evaluation-of-electronic-medical-record-penicillin-allergy-documentation-at-a-tertiary-community-teaching-hospital
#15
Mary L Staicu, Matthew Plakosh, Allison Ramsey
No abstract text is available yet for this article.
July 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28577519/drug-allergy-evaluation-for-betalactam-hypersensitivity-cross-reactivity-with-cephalosporines-carbapenems-and-negative-predictive-value
#16
Mona Al-Ahmad, Tito Rodriguez-Bouza
BACKGROUND: There are no studies on cross-reactivity of betalactams among patients allergic to penicillin, or on the negative predictive value (NPV) of penicillin allergy evaluation from Arabian Gulf countries OBJECTIVE: We aimed to assess the role and NPV of drug provocation test (DPT) for betalactam hypersensitivity reactions in patients referred for allergy evaluation in Kuwait METHODS: Skin test (ST) was performed for all patients with a history of betalactam hypersensitivity, other than anaphylaxis...
June 1, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28562129/fetal-response-to-intramuscular-epinephrine-for-anaphylaxis-during-maternal-penicillin-desensitization-for-secondary-syphilis
#17
Shan Shan Wu, Tina Abraham, Chelsea Michaud, Brian Peppers, Andrea Ward, Stacey Ehrenberg Buchner, Catalina V Teba, Haig Tcheurekdjian, Robert Hostoffer, Devi Jhaveri
Penicillin desensitization is indicated in pregnant patients with severe allergies to penicillin with syphilis. The immediate effects of intramuscular epinephrine on the fetus during desensitization remain unreported. We describe a pregnant patient with secondary syphilis and penicillin allergy who developed anaphylaxis during penicillin desensitization. Anaphylaxis resolved after administration of intramuscular epinephrine. Throughout the procedure, continuous electronic fetal monitoring showed a stable fetus without a decrease in variability, tachycardia, decelerations or signs of fetal distress...
May 31, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28540641/evaluation-of-penicillin-allergy-in-the-hospitalized-patient-opportunities-for-antimicrobial-stewardship
#18
REVIEW
Justin R Chen, David A Khan
PURPOSE OF REVIEW: Penicillin allergy is often misdiagnosed and is associated with adverse consequences, but testing is infrequently done in the hospital setting. This article reviews historical and contemporary innovations in inpatient penicillin allergy testing and its impact on antimicrobial stewardship. RECENT FINDINGS: Adoption of the electronic medical record allows rapid identification of admitted patients carrying a penicillin allergy diagnosis. Collaboration with clinical pharmacists and the development of computerized clinical guidelines facilitates increased testing and appropriate use of penicillin and related β-lactams...
June 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28539186/a-survey-of-inpatient-practitioner-knowledge-of-penicillin-allergy-at-2-community-teaching-hospitals
#19
Mary L Staicu, Dipekka Soni, Kelly M Conn, Allison Ramsey
BACKGROUND: The negative effect of the penicillin allergy label on antibiotic use and patient outcomes has brought to light the need for thorough penicillin allergy assessments and heightened practitioner education. OBJECTIVE: To evaluate practitioner knowledge of penicillin allergy and the clinical approach to the patients with penicillin allergy. METHODS: An electronic survey was distributed to attending physicians, residents, pharmacists, nurse practitioners, and physician assistants practicing adult inpatient medicine at 2 community-based teaching hospitals from February to April 2016...
July 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28522282/quality-indicators-for-the-use-of-systemic-antibiotics-in-dentistry
#20
Rugzan Jameel Hussein, Robert Krohn, Petra Kaufmann-Kolle, Gerald Willms
BACKGROUND: Risks resulted from using systemic antibiotics such as increasing rates of bacterial resistance, allergy and side effects should be always weighed individually for each patient against any potential benefits. Routine antibiotic prescribing must be therefore discouraged. The Federal Joint Committee ("Gemeinsamer Bundesauschuss", G-BA) commissioned the AQUA-Institute with the development of an external quality assurance procedure, examining systemic antibiotic use in periodontal, conservative and surgical treatments in ambulatory dental health care...
May 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
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