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JOURNAL ARTICLE
Marek Niedoszytko, Aleksandra Gorska, Knut Brockow, Patrizia Bonadonna, Magdalena Lange, Hanneke Kluin-Nelemans, Hanneke Oude-Elberink, Vito Sabato, Khalid Shoumariyeh, Dagmar von Bubnoff, Sabine Müller, Anja Illerhaus, Michael Doubek, Irena Angelova-Fischer, Olivier Hermine, Michel Arock, Chiara Elena, Luca Malcovati, Akif Selim Yavuz, Tanja Daniela Schug, Anna Belloni Fortina, Várkonyi Judit, Jason Gotlib, Jens Panse, Vladan Vucinic, Andreas Reiter, Juliana Schwaab, Massimo Triggiani, Mattias Mattsson, Christine Breynaert, Jan Romantowski, Roberta Zanotti, Elisa Olivieri, Alexander Zink, Annick van de Ven, Alex Stefan, Stephane Barete, Francesca Caroppo, Cecelia Perkins, Vanessa Kennedy, Deborah Christen, Mohamad Jawhar, Johannes Luebke, Roberta Parente, Kerstin Levedahl, Emir Hadzijusufovic, Karin Hartmann, Boguslaw Nedoszytko, Wolfgang R Sperr, Peter Valent
BACKGROUND: Hypersensitivity reactions (HR) are common in mastocytosis. However, little is known about triggers and risk factors. The registry of the European Competence Network on Mastocytosis (ECNM) enables reliable studies in a larger cohort of mastocytosis patients. We assessed prevalence, triggers and risk factors of HR in adults with mastocytosis in the ECNM registry. METHODS: Data were collected in 27 ECNM centers. We analyzed potential triggers (Hymenoptera venoms, food, drug, inhalant and others) and risk factors at diagnosis and during follow-up...
April 23, 2024: Allergy
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JOURNAL ARTICLE
Jennifer L Hamilton, Leon McCrea Ii
Group A beta-hemolytic streptococcal pharyngitis is a common infection responsible for more than 6 million office visits in the United States annually. Only 10% of adults seeking care for a sore throat have group A beta-hemolytic streptococcal pharyngitis; however, 60% or more are prescribed antibiotics. Guidelines recommend using clinical decision rules to assess the risk of group A beta-hemolytic streptococcal infection, followed by rapid antigen testing if a diagnosis is unclear, before prescribing antibiotics...
April 2024: American Family Physician
#3
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 2024: American Family Physician
#4
JOURNAL ARTICLE
Miriam Sobrino-García, Francisco J Muñoz-Bellido, Esther Moreno-Rodilla, Rita Martín-Muñoz, Aránzazu García-Iglesias, Ignacio Dávila
BACKGROUND: Patients with a penicillin allergy label are at risk of an associated increase in adverse antibiotic events and hospitalization costs. AIM: We aimed to study the economic savings derived from the correct diagnosis and delabeling inpatients with suspected beta-lactam allergy, considering the acquisition cost of antimicrobials prescribed during a patient's hospital stay. METHOD: We prospectively evaluated patients admitted to the University Hospital of Salamanca who had been labeled as allergic to beta-lactams and performed a delabeling study...
April 20, 2024: International Journal of Clinical Pharmacy
#5
JOURNAL ARTICLE
Qianwen Shi, Gege Wang, Shuhui Wang, Chao Zhang, Zhiwen Wei, Zhongyuan Guo, Dan Zhang, Keming Yun, Shanlin Fu
PURPOSE: A rapid and reliable method was developed and validated for the simultaneous analysis of 52 antibiotics (cephalosporins, penicillins, carbapenems, lincosamides, quinolones, nitroimidazoles, macrolides, sulfonamides, tetracyclines, glycopeptide) in urine and whole blood by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). METHOD: Analytes were extracted by dilution or protein precipitation and analyzed on an Agilent 1260 HPLC system coupled to an Agilent 6470 Triple Quadrupole Mass Spectrometer...
April 20, 2024: Forensic Toxicology
#6
JOURNAL ARTICLE
Devangi Shah, Jeffrey M Chambliss, Rory E Nicolaides, Timothy G Chow
No abstract text is available yet for this article.
April 16, 2024: Journal of Allergy and Clinical Immunology in Practice
#7
JOURNAL ARTICLE
Jane Cy Wong, Andy Kc Kan, Thomas Sh Chik, M Y Chu, Timothy Cm Li, Hugo Wf Mak, Valerie Chiang, Philip H Li
BACKGROUND: Penicillin "allergy" labels are prevalent but frequently misdiagnosed. Mislabelled allergies are associated with adverse outcomes and increased antimicrobial resistance. With an urgent need to delabel the overwhelming number of mislabelled allergies, non-allergist evaluations have been advocated for low-risk individuals. Despite growing interest in non-allergist-led initiatives; evidence on their effectiveness, safety, and impact by direct comparisons are lacking. OBJECTIVE: We assessed the comparative outcomes of penicillin allergy evaluations conducted by allergists vs...
April 15, 2024: Journal of Allergy and Clinical Immunology in Practice
#8
REVIEW
Teresa K L Boitano, Abinash Virk, J Michael Straughn, Sean C Dowdy
Surgical site infections (SSI) are one of the most common gynecologic oncology postoperative complications and they have a significant deleterious impact on the healthcare system and in patients' outcomes. Cefazolin is the recommended antibiotic in women undergoing gynecologic surgical procedures that require that require prophylaxis. However, 10-20% of patients may report a penicillin allergy which can result in administration of a less effective antibiotic. This quality review evaluated the literature around this common perioperative issue and demonstrated that healthcare teams should consider the implementation of a protocol to safely use cefazolin in most patients with a penicillin allergy...
June 2024: Gynecologic Oncology Reports
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JOURNAL ARTICLE
Anne Knisely, Maria D Iniesta, Claire A Marten, Gary Chisholm, Kathleen M Schmeler, Jolyn S Taylor
BACKGROUND: Surgical site infection (SSI) is one of the most common complications of gynecologic cancer surgery. Current guidelines recommend the administration of cefazolin pre-operatively to reduce SSI rates for patients undergoing clean-contaminated surgeries such as hysterectomy. OBJECTIVE: To evaluate the impact of a quality improvement project adding metronidazole to cefazolin for antibiotic prophylaxis on SSI rate for women undergoing gynecologic surgery at a comprehensive cancer center...
April 8, 2024: American Journal of Obstetrics and Gynecology
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JOURNAL ARTICLE
Shawn Meehl, Christina Salathe, Chelsea Cooley, Alejandro Jordan-Villegas, Federico R Laham, Akshita Madala, Mallory Cowart
OBJECTIVE: To assess the ability to de-label pediatric patients of their beta-lactam allergy by using a newly implemented institutional protocol and to identify potential barriers to the de-labeling process. METHODS: All patients with reported allergies to prespecified beta-lactam antibiotics were eligible for a -beta-lactam allergy interview. Following the interview, patients were grouped into 4 risk categories-no risk, low risk, moderate risk, and high risk-and assessed for intervention eligibility...
April 2024: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
#11
Naharuthai Bumrungratanayos, Songphol Tungjitviboonkun
A 56-year-old Thai male, known for allergies to penicillin, sulfa, and lincosamide, presented with hyperferritinemia. Upon initiating deferiprone therapy, the patient experienced recurrent episodes of dyspnea, culminating in anaphylactic shock. Treatment included subcutaneous epinephrine, intravenous chlorpheniramine, and hydrocortisone, which led to symptom resolution. This case constitutes the first case report of deferiprone-associated anaphylactic reactions.
April 2024: Curēus
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JOURNAL ARTICLE
Morgan T Rose, Elise A Mitri, Sara Vogrin, Natasha E Holmes, Kyra Y L Chua, Monica A Slavin, Jason A Trubiano
No abstract text is available yet for this article.
April 4, 2024: Journal of Allergy and Clinical Immunology in Practice
#13
JOURNAL ARTICLE
Frédéric Brillant-Marquis, Émilie Proulx, Kayadri Ratnarajah, Aubert Lavoie, Amélie Gauthier, Rémi Gagnon, Jean-Nicolas Boursiquot, Nina Verreault, Louis Marois, Marc-Antoine Bédard, Martine Boivin, Pierre-Michel Bédard, Manale Ouakki, Gaston De Serres, Jean-Philippe Drolet
BACKGROUND: About 10% of patients have a penicillin allergy label, but less than 5% of them are actually allergic. Unnecessary penicillin avoidance is associated with serious medical consequences. Given the growing number of these labels, it is imperative that our diagnostic strategy for penicillin allergy be as efficient as possible. The validity of traditionally used skin tests (STs) has been questioned, whereas drug provocation testing (DPT), the criterion standard, without previous ST appears very safe in most cases...
February 2024: Journal of Allergy and Clinical Immunology in Practice
#14
JOURNAL ARTICLE
Devyani Bakshi, Xinxin Tang, Susan Waserman
BACKGROUND: Serum-sickness like reactions (SSLRs) to amoxicillin have been documented in the medical literature. Beta-lactams are important and commonly used medications especially in the pediatric population. Often, SSLRs present within days of and during first exposure/ingestion to the offending agent. We described a unique case of a 4-year-old boy who presented with symptoms of amoxicillin SSLR following his second course of amoxicillin with only 2 months and 10 days between his second and first course...
April 1, 2024: Allergy, Asthma, and Clinical Immunology
#15
JOURNAL ARTICLE
Oyindamola Stephanie Kayode, Alla Nakonechna, Leonard Quok Chean Siew, Magdalena Dziadzio, Lucinda Kennard, Krzysztof Rutkowski, Rita Mirakian, Annette Wagner
BACKGROUND: Immediate IgE-mediated hypersensitivity reactions to polyethylene glycol (PEG) are rare. Our understanding of PEG hypersensitivity is limited. OBJECTIVE: We evaluated the clinical characteristics and investigation outcomes of the largest cohort of PEG-allergic patients reported. METHODS: 44 patients investigated for suspected PEG allergy across four UK tertiary allergy centres between October 2013 and December 2020 were studied...
March 30, 2024: Annals of Allergy, Asthma & Immunology
#16
REVIEW
Stamatios Petousis, Panagiota Angelou, Aristarchos Almperis, Antonio Simone Laganà, Gerasimos Titilas, Chrysoula Margioula-Siarkou, Konstantinos Dinas
Surgical site infections (SSIs) refer to infections in the incision, organ, or postoperative space. As common healthcare-associated infections, SSIs correlate with prolonged hospital stay, additional procedures, ICU stay, and higher mortality rates. Around 8-10% of gynecologic surgery patients may experience infectious complications, influenced by microbial contamination, surgical nature, and patient factors. The goal of this narrative review is to compare and merge recommendations from globally published guidelines concerning the utilization of antibiotics in the perioperative phase...
March 21, 2024: Journal of Personalized Medicine
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JOURNAL ARTICLE
(no author information available yet)
Overview of: Copaescu AM, Vogrin S, James F, et al. Efficacy of a clinical decision rule to enable direct oral challenge in patients with low-risk penicillin allergy: The PALACE randomized clinical trial. JAMA Intern Med 2023;183:944-52.
March 25, 2024: Drug and Therapeutics Bulletin
#18
JOURNAL ARTICLE
Karley J Dutra, Gweneth B Lazenby, Oluwatosin Goje, David E Soper
Cefazolin is the most common antibiotic used for prophylaxis in obstetrics and gynecology. Among those with a penicillin allergy, alternative antibiotics are often chosen for prophylaxis given fears of cross-reactivity between penicillin and cefazolin. Alternative antibiotics in this setting are associated with adverse sequalae including surgical site infection, induction of bacterial resistance, higher costs to the healthcare system, and possible Clostridium difficile infection. Given the difference in R1 side chains between the penicillin and cefazolin, cefazolin use is safe and should be recommended for penicillin allergic patients including those who experience IgE-mediated reactions such as anaphylaxis...
March 23, 2024: American Journal of Obstetrics and Gynecology
#19
JOURNAL ARTICLE
Lulu R Tsao, Shan Wen, Robyn C Lamar, Roxanna A Irani, Iris M Otani
No abstract text is available yet for this article.
March 21, 2024: Annals of Allergy, Asthma & Immunology
#20
JOURNAL ARTICLE
Ashlan J Kunz Coyne, Dana Holger, Erinne Kennedy, Mackenzie Connell, Juliann Binienda, Christopher Giuliano, Elaine M Bailey
BACKGROUND: Dental appointments offer an opportunity to evaluate a documented penicillin (PCN) allergy and determine whether the patient might be a candidate for medical reassessment of their allergy. The authors gathered feedback on the Penicillin Allergy Reassessment for Treatment Improvement (PARTI) tool, designed to enhance dentist-patient communications regarding PCN allergies. METHODS: From January 2022 through May 2023, the authors conducted a mixed-methods study, collecting focus group data from patients with PCN allergies and surveying health care workers (HCWs) regarding the PARTI tool...
March 21, 2024: Journal of the American Dental Association
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