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https://www.readbyqxmd.com/read/29659082/is-hepatic-peroxisome-proliferator-activated-receptor-%C3%AE-essential-for-the-metabolic-effects-of-fibrates
#1
EDITORIAL
Y Kamijo
No abstract text is available yet for this article.
May 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29626467/cooperation-of-rho-family-proteins-rac1-and-cdc42-in-cartilage-development-and-calcified-tissue-formation
#2
Mikiko Ikehata, Atsushi Yamada, Koji Fujita, Yuko Yoshida, Tadashi Kato, Akiko Sakashita, Hiroaki Ogata, Takehiko Iijima, Masahiko Kuroda, Daichi Chikazu, Ryutaro Kamijo
Rac1 and Cdc42, Rho family low molecular weight G proteins, are intracellular signaling factors that transmit various information from outside to inside cells. Primarily, they are known to control various biological activities mediated by actin cytoskeleton reorganization, such as cell proliferation, differentiation, and apoptosis. In order to investigate the functions of Rac1 and Cdc42 in bone formation, we prepared cartilage-specific double conditional knockout mice, Rac1fl/fl ; Cdc42fl/fl ; Col2-Cre (Rac1: Cdc42 dcKO mice), which died just after birth, similar to Cdc42fl/fl ; Col2-Cre mice (Cdc42 cKO mice)...
April 4, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29605670/serum-soluble-cd48-levels-as-a-prognostic-marker-in-mycosis-fungoides-and-s%C3%A3-zary-syndrome
#3
Tomonori Oka, Tomomitsu Miyagaki, Naomi Takahashi, Rina Nakajima, Hiroaki Kamijo, Hiraku Suga, Yoshihide Asano, Makoto Sugaya, Shinichi Sato
No abstract text is available yet for this article.
March 29, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29526946/a-retrospective-study-on-the-epidemiological-and-clinical-features-of-emergency-patients-with-large-or-massive-consumption-of-caffeinated-supplements-or-energy-drinks-in-japan
#4
Yoshito Kamijo, Michiko Takai, Yuji Fujita, Kiyotaka Usui
Objective We conducted a retrospective study on the epidemiological and clinical features of patients with acute caffeine poisoning in Japan. Methods Letters requesting participation were sent to 264 emergency departments of hospitals, and questionnaires were mailed to those that agreed to participate. Patients Participants were patients transported to emergency departments of hospitals between April 2011 and March 2016 after consuming large or massive amounts of caffeinated supplements and/or energy drinks (caffeine dose ≥1...
March 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29507419/ezh2-regulates-neuroblastoma-cell-differentiation-via-ntrk1-promoter-epigenetic-modifications
#5
Zhenghao Li, Hisanori Takenobu, Amallia Nuggetsiana Setyawati, Nobuhiro Akita, Masayuki Haruta, Shunpei Satoh, Yoshitaka Shinno, Koji Chikaraishi, Kyosuke Mukae, Jesmin Akter, Ryuichi P Sugino, Atsuko Nakazawa, Akira Nakagawara, Hiroyuki Aburatani, Miki Ohira, Takehiko Kamijo
The polycomb repressor complex 2 molecule EZH2 is now known to play a role in essential cellular processes, namely, cell fate decisions, cell cycle regulation, senescence, cell differentiation, and cancer development/progression. EZH2 inhibitors have recently been developed; however, their effectiveness and underlying molecular mechanisms in many malignancies have not yet been elucidated in detail. Although the functional role of EZH2 in tumorigenesis in neuroblastoma (NB) has been investigated, mutations of EZH2 have not been reported...
March 6, 2018: Oncogene
https://www.readbyqxmd.com/read/29467250/different-contributions-of-nonmuscle-myosin-iia-and-iib-to-the-organization-of-stress-fiber-subtypes-in-fibroblasts
#6
Masahiro Kuragano, Taro Qp Uyeda, Keiju Kamijo, Yota Murakami, Masayuki Takahashi
Stress fibers (SFs) are contractile, force-generating bundled structures that can be classified into three subtypes, namely, ventral SFs (vSFs), transverse arcs (TAs), and dorsal SFs. Nonmuscle myosin II (NMII) is the main component of SFs. This study examined the roles of the NMII isoforms NMIIA and NMIIB in the organization of each SF subtype in immortalized fibroblasts. Knockdown (KD) of NMIIA (a major isoform) resulted in loss of TAs from the lamella and caused the lamella to lose its flattened shape. Exogenous expression of NMIIB rescued this defect in TA formation...
February 21, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29455334/septicemia-from-lactobacillus-rhamnosus-gg-from-a-probiotic-enriched-yogurt-in-a-patient-with-autologous-stem-cell-transplantation
#7
Satoshi Koyama, Hiroyuki Fujita, Takeshi Shimosato, Aki Kamijo, Yasufumi Ishiyama, Eri Yamamoto, Yoshimi Ishii, Yukako Hattori, Maki Hagihara, Etsuko Yamazaki, Naoto Tomita, Hideaki Nakajima
Probiotic-rich foods are consumed without much restriction. We report here, a case of septic shock caused by yogurt derived Lactobacillus species in a 54-year-old male patient with acute promyelocytic leukemia, in second complete remission, and who was an autologous stem cell transplantation recipient. He received high dose chemotherapy and autologous peripheral blood stem cell transplantation. He ingested commercially available probiotic-enriched yogurt because of severe diarrhea. One week later, he developed septic shock, and the pathogen was determined by strain-specific PCR analysis as Lactobacillus rhamnosus GG (ATCC 53103), which was found to be identical with the strain in the yogurt he consumed...
February 17, 2018: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29447852/loss-of-red-opsin-genes-relaxes-sexual-isolation-between-skin-colour-variants-of-medaka
#8
Makiko Kamijo, Mayuko Kawamura, Shoji Fukamachi
Colour vision is often essential for animals. Fine discrimination of colours enhances the ability of animals to find food, predators, or mating partners. Using two colour variants of medaka (Oryzias latipes), which mate assortatively depending on visual cues (pale grey versus dark orange), we recently established red colour-blind strains by knocking out the red opsin (long-wavelength-sensitive) genes and elucidated that the fish were indeed insensitive to red light. In the present study, we investigated the mate choice of these red-blind fish...
February 12, 2018: Behavioural Processes
https://www.readbyqxmd.com/read/29426602/airway-inflammation-after-epicutaneous-sensitization-of-mice-requires-protease-activity-of-low-dose-allergen-inhalation
#9
Izumi Nishioka, Toshiro Takai, Natsuko Maruyama, Seiji Kamijo, Punyada Suchiva, Mayu Suzuki, Shinya Kunimine, Hirono Ochi, Sakiko Shimura, Katsuko Sudo, Hideoki Ogawa, Ko Okumura, Shigaku Ikeda
No abstract text is available yet for this article.
January 31, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29422267/impact-of-a-negative-d-dimer-result-on-the-initial-assessment-of-acute-aortic-dissection
#10
Kenichi Nitta, Hiroshi Imamura, Yuichiro Kashima, Hiroshi Kamijo, Michitaro Ichikawa, Mayumi Okada, Katsunori Mochizuki, Hiroshi Takayama
BACKGROUND: D-dimer shows high sensitivity but low specificity for the diagnosis of acute aortic dissection (AAD). Previous reports indicated that negative D-dimer patients have shorter dissection length. However, whether patients with negative D-dimer results have a good prognosis is unknown. This study aimed to elucidate the clinical characteristics and implications of a negative D-dimer result on AAD diagnosis. METHODS: The study group comprised 126 patients (71 males, 55 females; mean age, 69 ± 11 years) with AAD admitted to our hospital between April 2009 and March 2015...
January 31, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29358034/the-effects-of-a-school-based-exercise-program-on-neurophysiological-indices-of-working-memory-operations-in-adolescents
#11
Sebastian Ludyga, Markus Gerber, Keita Kamijo, Serge Brand, Uwe Pühse
OBJECTIVES: To examine the effects of a structured exercise program implemented during school break-time on working memory maintenance and neurophysiological indices of task preparation processes in adolescents. DESIGN: Using class-wise random allocation, participants from four classes were divided into an exercise (n=20) and a wait-list control group (n=16). Over a period of eight weeks, the exercise group engaged in 20min of combined aerobic and coordinative exercise on each school day...
January 10, 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29349637/association-between-keeping-home-records-of-catheter-exit-site-and-incidence-of-peritoneal-dialysis-related-infections
#12
Hidekazu Iida, Noriaki Kurita, Shino Fujimoto, Yuka Kamijo, Yoshitaka Ishibashi, Shingo Fukuma, Shunichi Fukuhara
PURPOSE: To prevent peritoneal dialysis (PD)-related infection, components of self-catheter care have been emphasized. However, studies on the effectiveness of home recording for the prevention of PD-related infections are limited. This study aimed to examine the association between keeping home records of catheter exit site and incidence of PD-related infections. METHODS: Home record books were submitted by patients undergoing PD. The proportion of days on which exit-site home recording was carried out for 120 days (0-100%) was obtained...
April 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29330514/a-comparison-of-static-and-dynamic-cerebral-autoregulation-during-mild-whole-body-cold-stress-in-individuals-with-and-without-cervical-spinal-cord-injury-a-pilot-study
#13
Jan W van der Scheer, Yoshi-Ichiro Kamijo, Christof A Leicht, Philip J Millar, Manabu Shibasaki, Victoria L Goosey-Tolfrey, Fumihiro Tajima
STUDY DESIGN: Experimental study. OBJECTIVES: To characterize static and dynamic cerebral autoregulation (CA) of individuals with cervical spinal cord injury (SCI) compared to able-bodied controls in response to moderate increases in mean arterial pressure (MAP) caused by mild whole-body cold stress. SETTING: Japan METHODS: Five men with complete autonomic cervical SCI (sustained > 5 y) and six age-matched able-bodied men participated in hemodynamic, temperature, catecholamine and respiratory measurements for 60 min during three consecutive stages: baseline (10 min; 33 °C water through a thin-tubed whole-body suit), mild cold stress (20 min; 25 °C water), and post-cold recovery (30 min; 33 °C water)...
January 12, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29306105/distinct-gene-alterations-with-a-high-percentage-of-myeloperoxidase-positive-leukemic-blasts-in-de-novo-acute-myeloid-leukemia
#14
Rena Kamijo, Hidehiro Itonaga, Rika Kihara, Yasunobu Nagata, Tomoko Hata, Norio Asou, Shigeki Ohtake, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seishi Ogawa, Tomoki Naoe, Hitoshi Kiyoi, Yasushi Miyazaki
The myeloperoxidase (MPO)-positivity of blasts in bone marrow smears is an important marker for not only the diagnosis, but also the prognosis of acute myeloid leukemia (AML). To investigate the relationship between genetic alterations and MPO-positivity, we performed targeted sequencing for 51 genes and 10 chimeric gene transcripts in 164 newly diagnosed de novo AML patients; 107 and 57 patients were classified as AML with >50% MPO-positive blasts (MPO-high group) and ≤50% MPO-positive blasts, (MPO-low group), respectively...
February 2018: Leukemia Research
https://www.readbyqxmd.com/read/29300095/synthesis-of-2-iodoazulenes-by-the-iododeboronation-of-azulen-2-ylboronic-acid-pinacol-esters-with-copper-i-iodide
#15
Masahiro Narita, Toshihiro Murafuji, Saki Yamashita, Masayuki Fujinaga, Kumiko Hiyama, Yurie Oka, Fumito Tani, Shin Kamijo, Katsuya Ishiguro
Azulen-2-ylboronic acid pinacol ester, prepared by iridium-catalyzed C-H borylation of azulene, efficiently underwent iododeboronation with a stoichiometric amount of copper(I) iodide. This reaction allowed the synthesis of 2-iodoazulene in only two steps starting from azulene. This methodology was successfully applied to analogous azulenes.
February 2, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29296183/identification-of-the-genetic-and-clinical-characteristics-of-neuroblastomas-using-genome-wide-analysis
#16
Kumiko Uryu, Riki Nishimura, Keisuke Kataoka, Yusuke Sato, Atsuko Nakazawa, Hiromichi Suzuki, Kenichi Yoshida, Masafumi Seki, Mitsuteru Hiwatari, Tomoya Isobe, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Katsuyoshi Koh, Ryoji Hanada, Akira Oka, Yasuhide Hayashi, Miki Ohira, Takehiko Kamijo, Hiroki Nagase, Tetsuya Takimoto, Tatsuro Tajiri, Akira Nakagawara, Seishi Ogawa, Junko Takita
To provide better insight into the genetic signatures of neuroblastomas, we analyzed 500 neuroblastomas (included specimens from JNBSG) using targeted-deep sequencing for 10 neuroblastoma-related genes and SNP arrays analysis. ALK expression was evaluated using immunohistochemical analysis in 259 samples. Based on genetic alterations, the following 6 subgroups were identified: groups A ( ALK abnormalities), B (other gene mutations), C ( MYCN amplification), D (11q loss of heterozygosity [LOH]), E (at least 1 copy number variants), and F (no genetic changes)...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29290949/neurocan-an-extracellular-chondroitin-sulfate-proteoglycan-stimulates-neuroblastoma-cells-to-promote-malignant-phenotypes
#17
Zhendong Su, Satoshi Kishida, Shoma Tsubota, Kazuma Sakamoto, Dongliang Cao, Shinichi Kiyonari, Miki Ohira, Takehiko Kamijo, Atsushi Narita, Yinyan Xu, Yoshiyuki Takahashi, Kenji Kadomatsu
Neurocan (NCAN), a secreted chondroitin sulfate proteoglycan, is one of the major inhibitory molecules for axon regeneration in nervous injury. However, its role in cancer is not clear. Here we observed that high NCAN expression was closely associated with the unfavorable outcome of neuroblastoma (NB). NCAN was also highly and ubiquitously expressed in the early lesions and terminal tumor of TH- MYCN mice, a NB model. Interestingly, exogenous NCAN (i.e., overexpression, recombinant protein and conditioned medium) transformed adherent NB cells into spheres whose malignancies in vitro (anchorage-independent growth and chemoresistance) and in vivo (xenograft tumor growth) were potentiated...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29213329/oxygen-radical-pretreatment-promotes-cellulose-degradation-by-cellulolytic-enzymes
#18
Kiyota Sakai, Saki Kojiya, Junya Kamijo, Yuta Tanaka, Kenta Tanaka, Masahiro Maebayashi, Jun-Seok Oh, Masafumi Ito, Masaru Hori, Motoyuki Shimizu, Masashi Kato
Background: The efficiency of cellulolytic enzymes is important in industrial biorefinery processes, including biofuel production. Chemical methods, such as alkali pretreatment, have been extensively studied and demonstrated as effective for breaking recalcitrant lignocellulose structures. However, these methods have a detrimental effect on the environment. In addition, utilization of these chemicals requires alkali- or acid-resistant equipment and a neutralization step. Results: Here, a radical generator based on non-thermal atmospheric pressure plasma technology was developed and tested to determine whether oxygen-radical pretreatment enhances cellulolytic activity...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29186561/identification-of-5-fluoro-adb-in-human-whole-blood-in-four-death-cases
#19
Kiyotaka Usui, Yuji Fujita, Yoshito Kamijo, Tetsuo Kokaji, Masato Funayama
Four deaths that seemed to have been caused by a designer drug occurred within a 3-week period in Sendai, Japan. In each case, the decedent possessed the same sachet, labeled "Heart Shot BLACK", which contained a dried plant material with an aromatic scent. It was revealed in our analysis that the product contained a synthetic cannabinoid receptor agonist, 5-fluoro ADB (methyl 2-[1-(5-fluoropentyl)-1H-indazole-3-carboxamide]-3,3-dimethylbutanoate, also known as 5-fluoro MDMB-PINACA), which is now classified as a restricted designer drug in Japan after it caused several casualties...
November 24, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29183803/8-nitro-cgmp-is-a-promoter-of-osteoclast-differentiation-induced-by-rankl
#20
K Kaneko, Y Miyamoto, R Tsukuura, K Sasa, T Akaike, S Fujii, K Yoshimura, K Nagayama, M Hoshino, S Inoue, K Maki, K Baba, D Chikazu, R Kamijo
Osteoclasts are multinucleated giant cells differentiated from monocyte-macrophage-lineage cells under stimulation of receptor activator of nuclear factor κ-B (RANK) ligand (RANKL) produced by osteoblasts and osteocytes. Although it has been reported that nitric oxide (NO) and reactive oxygen species (ROS) are involved in this process, the mechanism by which these labile molecules promote osteoclast differentiation are not fully understood. In this study, we investigated the formation and function of 8-nitro-cGMP, a downstream molecule of NO and ROS, in the process of osteoclast differentiation in vitro...
January 30, 2018: Nitric Oxide: Biology and Chemistry
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