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https://www.readbyqxmd.com/read/29213329/oxygen-radical-pretreatment-promotes-cellulose-degradation-by-cellulolytic-enzymes
#1
Kiyota Sakai, Saki Kojiya, Junya Kamijo, Yuta Tanaka, Kenta Tanaka, Masahiro Maebayashi, Jun-Seok Oh, Masafumi Ito, Masaru Hori, Motoyuki Shimizu, Masashi Kato
Background: The efficiency of cellulolytic enzymes is important in industrial biorefinery processes, including biofuel production. Chemical methods, such as alkali pretreatment, have been extensively studied and demonstrated as effective for breaking recalcitrant lignocellulose structures. However, these methods have a detrimental effect on the environment. In addition, utilization of these chemicals requires alkali- or acid-resistant equipment and a neutralization step. Results: Here, a radical generator based on non-thermal atmospheric pressure plasma technology was developed and tested to determine whether oxygen-radical pretreatment enhances cellulolytic activity...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29186561/identification-of-5-fluoro-adb-in-human-whole-blood-in-four-death-cases
#2
Kiyotaka Usui, Yuji Fujita, Yoshito Kamijo, Tetsuo Kokaji, Masato Funayama
Four deaths that seemed to have been caused by a designer drug occurred within a 3-week period in Sendai, Japan. In each case, the decedent possessed the same sachet, labeled "Heart Shot BLACK", which contained a dried plant material with an aromatic scent. It was revealed in our analysis that the product contained a synthetic cannabinoid receptor agonist, 5-fluoro ADB (methyl 2-[1-(5-fluoropentyl)-1H-indazole-3-carboxamide]-3,3-dimethylbutanoate, also known as 5-fluoro MDMB-PINACA), which is now classified as a restricted designer drug in Japan after it caused several casualties...
November 24, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29183803/8-nitro-cgmp-is-a-promoter-of-osteoclast-differentiation-induced-by-rankl
#3
K Kaneko, Y Miyamoto, R Tsukuura, K Sasa, T Akaike, S Fujii, K Yoshimura, K Nagayama, M Hoshino, S Inoue, K Maki, K Baba, D Chikazu, R Kamijo
Osteoclasts are multinucleated giant cells differentiated from monocyte-macrophage-lineage cells under stimulation of receptor activator of nuclear factor κ-B (RANK) ligand (RANKL) produced by osteoblasts and osteocytes. Although it has been reported that nitric oxide (NO) and reactive oxygen species (ROS) are involved in this process, the mechanism by which these labile molecules promote osteoclast differentiation are not fully understood. In this study, we investigated the formation and function of 8-nitro-cGMP, a downstream molecule of NO and ROS, in the process of osteoclast differentiation in vitro...
November 25, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29159783/in-vitro-study-of-the-effects-of-denosumab-on-giant-cell-tumor-of-bone-comparison-with-zoledronic-acid
#4
Isao Shibuya, Masamichi Takami, Arei Miyamoto, Akiko Karakawa, Akira Dezawa, Shigeru Nakamura, Ryutaro Kamijo
Giant cell tumor of bone (GCTB) is a locally aggressive primary bone tumor that contains numerous osteoclasts formed from marrow-derived precursors through receptor activator of nuclear factor κ-B ligand (RANKL), an osteoclast differentiation factor expressed in neoplastic cells of GCTB. Denosumab, a fully human monoclonal antibody targeting RANKL, has recently been used for the treatment of GCTB, and superior treatment effects have been reported. The aim of this work was to elucidate the mechanism of action of denosumab, and the differences between denosumab and zoledronic acid at the level of GCTB cells...
November 20, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29129887/-analysis-of-backgrounds-and-level-of-understanding-of-treatment-of-poor-adherence-and-dropout-cases-on-sublingual-immunotherapy-for-japanese-cedar-pollinosis-in-the-first-follow-up-year
#5
Sayaka Kikkawa, Atsushi Kamijo, Kazuyuki Nakagome, Tomoyuki Soma, Takehito Kobayashi, Yoshitaka Uchida, Eiji Morita, Makoto Nagata, Tomoe Inoue, Yasuhiro Kase
BACKGROUND: We considered the factors of poor adherence to and dropout from sublingual immunotherapy (SLIT) by verifying patient backgrounds 1 year after start of treatment. METHODS: We recruited 38 patients who began SLIT between November 2014 and September 2015. We analyzed their attributes and level of understanding of the treatment, and conducted a self-reported survey on factors behind dropout cases and poor adherence cases. RESULTS: Four patients dropped out 1 year after start of treatment...
2017: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/29127555/continuous-monitoring-of-blood-pressure-by-analyzing-the-blood-flow-sound-of-arteriovenous-fistula-in-hemodialysis-patients
#6
Yuka Kamijo, Eiichiro Kanda, Hayato Horiuchi, Noriyuki Kounoue, Keisuke Ono, Keizo Maeda, Akane Yanai, Kazuya Honda, Ryuji Tsujimoto, Mai Yanagi, Yoshitaka Ishibashi, Masayuki Yoshida
BACKGROUND: Patients with end-stage renal disease undergoing hemodialysis (HD) have an elevated risk of cardiovascular disease-related morbidity and mortality. To prevent from such a life-threatening event, the continuous blood pressure (BP) monitoring system may contribute to detect BP decline in early stages and may help to do appropriate disposal. Our research team has introduced an electronic stethoscope (Asahi Kasei Co, Ltd., Tokyo, Japan), which translates sound intensity of Arteriovenous Fistula (AVF) to BP data using the technique of Fourier transformation that can predict continuous BP non-invasively...
November 10, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29081458/determination-of-formetanate-hydrochloride-in-agricultural-products-by-lc-ms-ms
#7
Maki Kobayashi, Naoko Sakai, Kyoko Kamijo, Hiroshi Koike, Satoru Nemoto, Tetsuya Shindo
An analytical method based on LC-MS/MS was developed for the determination of formetanate hydrochloride in agricultural products. Formetanate hydrochloride was confirmed to be stable in acetonitrile. It was therefore extracted from samples with acetonitrile, and the crude extracts were purified using a combination of ethylenediamine-N-propyl silylation silica gel and graphite carbon mini columns. Formetanate hydrochloride in the resulting sample solutions was quantified by LC-MS/MS utilizing an external solvent calibration curve...
2017: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
https://www.readbyqxmd.com/read/29073250/effects-of-physiatrist-and-registered-therapist-operating-acute-rehabilitation-pror-in-patients-with-stroke
#8
Tokio Kinoshita, Yukihide Nishimura, Takeshi Nakamura, Takamasa Hashizaki, Daisuke Kojima, Makoto Kawanishi, Hiroyasu Uenishi, Hideki Arakawa, Takahiro Ogawa, Yoshi-Ichiro Kamijo, Takashi Kawasaki, Fumihiro Tajima
OBJECTIVE: Clinical evidence suggests that early mobilization of patients with acute stroke improves activity of daily living (ADL). The purpose of this study was to compare the utility of the physiatrist and registered therapist operating acute rehabilitation (PROr) applied early or late after acute stroke. SUBJECTS AND METHODS: This study was prospective cohort study, assessment design. Patients with acute stroke (n = 227) admitted between June 2014 and April 2015 were divided into three groups based on the time of start of PROr: within 24 hours (VEM, n = 47), 24-48 hours (EM, n = 77), and more than 48 hours (OM, n = 103) from stroke onset...
2017: PloS One
https://www.readbyqxmd.com/read/29047213/baseline-and-time-averaged-values-predicting-residual-renal-function-decline-rate-in-japanese-peritoneal-dialysis-patients
#9
Kiyotaka Uchiyama, Akane Yanai, Keizo Maeda, Keisuke Ono, Kazuya Honda, Ryuji Tsujimoto, Yuka Kamijo, Mai Yanagi, Yoshitaka Ishibashi
Residual renal function (RRF) is a strong prognostic factor of morbidity and mortality in patients undergoing peritoneal dialysis (PD). We determined predictors of the RRF rate of decline using both baseline values and time-averaged ones. We retrospectively analyzed 94 patients being treated with PD at the Japanese Red Cross Medical Center. The decline rate of RRF was calculated by a diminution in the weekly renal Kt/V between the first and last follow up divided by follow-up years. The mean follow-up period was 2...
October 19, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29036640/toxicokinetics-of-the-synthetic-cathinone-%C3%AE-pyrrolidinohexanophenone
#10
Yuji Fujita, Toshinori Mita, Kiyotaka Usui, Yoshito Kamijo, Satoshi Kikuchi, Makoto Onodera, Yasuhisa Fujino, Yoshihiro Inoue
Synthetic cathinones inhibit monoamine transporters, such as serotonin, norepinephrine, and dopamine transporters, and act on the central nervous system via increasing synaptic concentrations of monoamines. These compounds, which are highly addictive and potentially poisonous, are new psychoactive substances. In this study, we investigated the toxicokinetics of the synthetic cathinone, α-pyrrolidinohexanophenone (α-PHP), and assessed the relationship between the toxicokinetics and the long-term clinical symptoms induced by α-PHP in a male patient...
September 28, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28985100/aerobic-exercise-during-encoding-impairs-hippocampus-dependent-memory
#11
Keishi Soga, Keita Kamijo, Hiroaki Masaki
We investigated how aerobic exercise during encoding affects hippocampus-dependent memory through a source memory task that assessed hippocampus-independent familiarity and hippocampus-dependent recollection processes. Using a within-participants design, young adult participants performed a memory-encoding task while performing a cycling exercise or being seated. The subsequent retrieval phase was conducted while sitting on a chair. We assessed behavioral and event-related brain potential measures of familiarity and recollection processes during the retrieval phase...
August 1, 2017: Journal of Sport & Exercise Psychology
https://www.readbyqxmd.com/read/28978980/role-of-bardoxolone-methyl-a-nuclear-factor-erythroid-2-related-factor-2-activator-in-aldosterone-and-salt-induced-renal-injury
#12
Mikako Hisamichi, Atsuko Kamijo-Ikemori, Takeshi Sugaya, Seiko Hoshino, Kenjiro Kimura, Yugo Shibagaki
The aim of this study was to investigate the renoprotective effect of bardoxolone methyl (BM), a nuclear factor erythroid 2-related factor 2 (Nrf2) activator with an antioxidant effect, in a salt-sensitive hypertension model induced by aldosterone (Ald) and salt. Tubulointerstitial damage with urinary liver-type fatty acid-binding protein (L-FABP) was evaluated using human L-FABP chromosomal transgenic (L-FABP(+/-)) male mice. The mice in the Ald group (n=7) received systemic Ald infusions via an osmotic minipump and were given 1% NaCl water for 35 days...
October 5, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28977598/rac1-dosage-is-crucial-for-normal-endochondral-bone-growth
#13
Dai Suzuki, Jason R Bush, Dawn-Marie Bryce, Ryutaro Kamijo, Frank Beier
Rac1, a member of the small Rho GTPase family, plays multiple cellular roles. Studies of mice conditionally lacking Rac1 have revealed essential roles for Rac1 in various tissues, including cartilage and limb mesenchyme, where Rac1 loss produces dwarfism and long bone shortening. To gain further insight into the role of Rac1 in skeletal development, we have used transgenic mouse lines to express a constitutively active (ca) Rac1 mutant protein in a Cre recombinase-dependent manner. Overexpression of caRac1 in limb bud mesenchyme or chondrocytes leads to reduced body weight and shorter bones compared with control mice...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28976540/effects-of-the-fitkids-physical-activity-randomized-controlled-trial-on-conflict-monitoring-in-youth
#14
Eric S Drollette, Matthew B Pontifex, Lauren B Raine, Mark R Scudder, R Davis Moore, Shih-Chun Kao, Daniel R Westfall, Chien-Ting Wu, Keita Kamijo, Darla M Castelli, Naiman A Khan, Arthur F Kramer, Charles H Hillman
The present study investigated the effect of a 9-month physical activity (PA) intervention on children's cardiorespiratory fitness levels and neuroelectric indices of conflict monitoring (i.e., error-related negativity, ERN). Four hundred twenty-eight preadolescent children (8-9 years old) were randomized into a PA intervention or wait-list control group, and completed a fitness and cognitive control assessment (i.e., modified flanker task) at pre- and posttest. Following exclusion criterion, 308 children were included in the analyses (PA intervention: n = 139; wait-list control: n = 169)...
October 4, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28967507/effects-of-zostera-marina-on-the-patterns-of-spatial-distribution-of-sediments-and-macrozoobenthos-in-the-boreal-lagoon-of-furen-hokkaido-japan
#15
P Magni, S Como, A Kamijo, S Montani
Understanding patterns of spatial variations in benthic seagrass assemblages is a central issue in seagrass ecology. However, how patterns of spatial variations in macrozoobenthos and associated sediments differ between vegetated and unvegetated areas remain largely unexplored. In the present study, two different habitats represented by dense Zostera marina beds (Zostera) and unvegetated sediments (Bare) were compared at three locations, 100's meters apart, located at progressive distance from the Furen river in the boreal lagoon of Furen (Hokkaido, Japan)...
October 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28948078/muscle-training-induced-bilateral-brachial-plexopathy-in-an-adolescent-with-sporadic-hereditary-neuropathy-with-liability-to-pressure-palsies
#16
Minori Kodaira, Satoshi Kodama, Yui Kamijo, Tomoki Kaneko, Yoshiki Sekijima
There have been few studies regarding physical training-induced peripheral nerve dysfunction in patients with hereditary neuropathy with liability to pressure palsies (HNPP), with the exception of soldiers that trained intensively. Here, we report a 15-year-old boy without family history of HNPP who developed bilateral painless brachial plexopathy following short-term barbell and plank training during a school baseball club activity. Muscle training-induced painless brachial plexopathy could be an initial symptom and may be underdiagnosed in adolescents with sporadic HNPP...
September 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28925057/serum-vascular-endothelial-growth-factor-a-levels-reflect-itch-severity-in-mycosis-fungoides-and-s%C3%A3-zary-syndrome
#17
Minami Sakamoto, Tomomitsu Miyagaki, Hiroaki Kamijo, Tomonori Oka, Naomi Takahashi, Hiraku Suga, Ayumi Yoshizaki, Yoshihide Asano, Makoto Sugaya, Shinichi Sato
Angiogenesis is an important step to support progression of malignancies, including mycosis fungoides (MF) and Sézary syndrome (SS). Vascular endothelial growth factor (VEGF)-A, a key player in angiogenesis, is secreted by tumor cells of MF/SS and its expression levels in lesional skin correlated with disease severity. In this study, we examined serum VEGF-A levels in MF/SS patients. Serum VEGF-A levels were elevated in patients with erythrodermic MF/SS and the levels decreased after treatment. Importantly, serum VEGF-A levels positively correlated with markers for pruritus...
September 19, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28915622/genomic-analysis-integrated-whole-exome-sequencing-of-neuroblastomas-identifies-genetic-mutations-in-axon-guidance-pathway
#18
Yuanyuan Li, Miki Ohira, Yong Zhou, Teng Xiong, Wen Luo, Chao Yang, Xiangchun Li, Zhibo Gao, Rui Zhou, Yohko Nakamura, Takehiko Kamijo, Yasuhiko Kaneko, Takeshi Taketani, Junichi Ueyama, Tatsuro Tajiri, Hongyan Zhang, Jian Wang, Huanming Yang, Ye Yin, Akira Nakagawara
Neuroblastoma (NB) is a childhood solid malignant tumor originating from precursor cells of the peripheral nervous system. We have previously established a risk classification system based on DNA copy number profiles. To further explore the pathogenesis of NBs in distinct risk groups, we performed whole-exome sequencing analysis of 57 primary and 7 recurrent/metastatic tumors with unique chromosomal aberration profiles as categorized by our genomic sub-grouping system. Overall, a low frequency of somatic mutations was found...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28888756/renoprotective-effect-of-the-xanthine-oxidoreductase-inhibitor-topiroxostat-under-decreased-angiotensin-ii-type-1a-receptor-expression
#19
Keiichi Ohata, Atsuko Kamijo-Ikemori, Takeshi Sugaya, Chihiro Hibi, Takashi Nakamura, Takayo Murase, Tsuyoshi Oikawa, Seiko Hoshino, Kimie Katayama, Junko Asano, Kenjiro Kimura, Yugo Shibagaki
The aim of this study was to confirm the renoprotective effect of xanthine oxidoreductase (XOR) inhibitor, topiroxostat, compared with another XOR inhibitor, febuxostat, under decreased angiotensin II type 1a (AT1a) receptor expression in the model of renal injury caused by adenine. To evaluate the degree of tubular damage using urinary liver-type fatty acid-binding protein (L-FABP) under decreased AT1a expression, we used AT1a receptor knockdown hetero and human L-FABP chromosomal transgenic (Tg) mice (AT1a(+/-)L-FABP(+/-))...
November 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28872349/urinary-liver-type-fatty-acid-binding-protein-is-associated-with-subendocardial-viability-ratio-in-middle-and-older-aged-adults
#20
Keisei Kosaki, Atsuko Kamijo-Ikemori, Takeshi Sugaya, Koichiro Tanahashi, Hiroshi Kumagai, Yuriko Sawano, Nobuhiko Akazawa, Yosuke Osuka, Kiyoji Tanaka, Kenjiro Kimura, Yugo Shibagaki, Seiji Maeda
BACKGROUND: To identify one of the physiological underlying mechanisms of the predictive effects of urinary liver-type fatty acid-binding protein (L-FABP) for the onset of cardiovascular disease (CVD), we investigated the relationship between urinary L-FABP levels and subendocardial viability ratio (SEVR), a marker of myocardial perfusion, in middle- and older-aged adults. METHODS: This was a cross-sectional study of 249 middle- and older-aged adults (aged 46-83 years)...
September 5, 2017: Clinical and Experimental Hypertension: CHE
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