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https://www.readbyqxmd.com/read/29775118/blood-flow-restricted-resistance-training-in-patients-with-sporadic-inclusion-body-myositis-a-randomized-controlled-trial
#1
A N Jørgensen, P Aagaard, U Frandsen, E Boyle, L P Diederichsen
OBJECTIVES: To investigate the effect of 12 weeks of low-load blood-flow restricted resistance (BFR) training on self-reported and objective physical function, and maximal muscle strength in patients with sporadic inclusion body myositis (sIBM). METHOD: Twenty-two patients with sIBM were randomized into a training group (BFR group) or a non-exercising control group, according to CONsolidated Standards Of Reporting Trials (CONSORT) guidelines. The BFR group performed 12 weeks of BFR training twice per week...
May 18, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29770517/validity-and-generalizability-of-findings-of-randomized-controlled-trials-on-arthroscopic-partial-meniscectomy-of-the-knee
#2
REVIEW
Antti Malmivaara
BACKGROUND: The validity and generalizability of evidence from trials on arthroscopic partial meniscectomy (APM) for a ruptured meniscus of the knee has been debated in scientific journals. OBJECTIVE: To assess the validity and generalizability of evidence for trials on effectiveness of APM by a novel Benchmarking method; and to compare this assessment with established assessment methods; and to make an overall assessment of the current evidence on validity and generalizability of findings...
May 16, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29764496/reporting-quality-of-randomized-controlled-trials-in-otolaryngology-review-of-adherence-to-the-consort-statement
#3
Yu Qing Huang, Katsiaryna Traore, Badr Ibrahim, Maida J Sewitch, Lily H P Nguyen
BACKGROUND: Randomized controlled trials are the gold standard in medical and surgical research to assess the efficacy of therapeutic interventions. The reporting of these trials should be of high quality to allow readers' appropriate interpretation and application. METHODS: The objectives of our study were to assess the extent to which the recent Otolaryngology - Head and Neck Surgery (ORL-HNS) randomized control trials in the top nine journals and in the top Canadian journal comply with the Consolidated Standards of Reporting Trials (CONSORT) statement, and to identify the CONSORT items most in need of improvement...
May 15, 2018: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29760282/the-c-elegans-ortholog-of-tdp-43-regulates-the-chromatin-localization-of-the-heterochromatin-protein-1-homolog-hpl-2
#4
Tassa K Saldi, Patrick Gonzales, Alfonso Garrido-Lecca, Vishantie Dostal, Christine M Roberts, Leonard Petrucelli, Christopher D Link
TDP-1 is the C. elegans ortholog of mammalian TDP-43, which is strongly implicated in the etiology of Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS). We discovered that deletion of the tdp-1 gene results in enhanced nuclear RNA interference (RNAi). As nuclear RNAi in C. elegans involves chromatin changes moderated by HPL-2, a homolog of heterochromatin protein 1 (HP1), we investigated the interaction of TDP-1 and HPL-2. We find that TDP-1 and HPL-2 interact directly, and loss of TDP-1 dramatically alters the chromatin association of HPL-2...
May 14, 2018: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29747793/reporting-quality-of-randomized-controlled-trials-of-periodontal-diseases-in-journal-abstracts-a-cross-sectional-survey-and-bibliometric-analysis
#5
Satish Kumar, Husain Mohammad, Hita Vora, Kian Kar
OBJECTIVE: Randomized controlled trials (RCTs) by proper design, conduct, analysis, and reporting provide reliable information in clinical care. Reporting of RCT abstracts is of equal importance as there is evidence that many clinicians will change their clinical decisions based on RCT abstracts. The reporting quality of RCT abstracts has been suboptimal. It is not clear whether the reporting quality is related to the journal metrics. The main objective of this study is to conduct a cross-sectional survey to evaluate the reporting quality of RCTs of periodontal diseases in journal abstracts and to perform a bibliometric analysis...
June 2018: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/29742449/quality-improvement-in-randomized-controlled-trial-abstracts-in-prosthodontics-since-the-publication-of-consort-guideline-for-abstracts-a-systematic-review
#6
REVIEW
Junsheng Chen, Zhi Li, Beilei Liu, Xueqi Gan, Chunjie Li, Haiyang Yu
OBJECTIVES: This study aimed to compare the reporting quality of randomized controlled trial (RCT) abstracts in prosthodontics before and after the publication of Consolidated Standards of Reporting Trials (CONSORT) guideline for abstracts and identify the characteristics associated with better reporting quality. SOURCES: PubMed was searched for RCT abstracts published from 2001 to 2007 (pre-CONSORT period) and from 2010 to 2016 (post-CONSORT period) in six leading prosthodontic journals...
May 6, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29737504/inadequate-harms-reporting-in-randomized-control-trials-of-antibiotics-for-pediatric-acute-otitis-media-a-systematic-review
#7
REVIEW
Stephanie W Hum, Su Golder, Nader Shaikh
INTRODUCTION: Reporting of harms in randomized control trials is often inconsistent and inadequate. OBJECTIVE: To assess the quality of harms reporting in randomized control trials evaluating the efficacy of antibiotics used to treat pediatric acute otitis media and to investigate whether connections to pharmaceutical companies or the publication of the CONSORT-Harms extension influenced the quality of harms reporting. STUDY DESIGN AND SETTING: We considered randomized control trials that evaluated the efficacy and safety of antibiotic treatment for uncomplicated acute otitis media in children aged 0-19...
May 8, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29730633/use-of-a-gp-endorsed-12-months-reminder-letter-to-promote-uptake-of-bowel-scope-screening-protocol-for-a-randomised-controlled-trial-in-a-hard-to-reach-population
#8
Christian von Wagner, Yasemin Hirst, Sara Tookey, Robert S Kerrison, Sarah Marshall, Andrew Prentice, Daniel Vulkan, Una Macleod, Stephen Duffy
INTRODUCTION: Flexible sigmoidoscopy (FS) screening is associated with reduced colorectal cancer incidence and mortality when offered as a one-off test to men and women aged 55-64. The test, also referred to as the 'bowel scope screening' (BSS) test, was added to England's national Bowel Cancer Screening Programme in March 2013, where it is offered to men and women aged 55. Since its implementation, uptake of the BSS test has been low, with only 43% of the eligible population attending an appointment...
May 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29727730/dor-agonist-snc-80-exhibits-anti-parkinsonian-effect-via-downregulating-upr-oxidative-stress-signals-and-inflammatory-response-in-vivo
#9
Erfath Thanjeem Begum M, Dwaipayan Sen
The pathophysiology of Parkinson's disease exhibit imperative roles in unfolded protein response stress-induced oxidative stress and inflammation in general. Although, delta opioid receptor (DOR), has been found to represent anti-parkinsonian effect at behavioral level, its underlying mechanism remains elusive till date. In the present study the role of DOR agonist, SNC-80 and the consorted molecular mechanisms, which translates to behavioral recuperation, has been delineated. In order to mimic PD, mice were intra-peritoneally injected with MPTP, following exposure to SNC-80 and L-DOPA to elucidate amelioration of the MPTP-induced behavioral impairments...
May 1, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29721269/size-assortative-choice-and-mate-availability-influences-hybridization-between-red-wolves-canis-rufus-and-coyotes-canis-latrans
#10
Joseph W Hinton, John L Gittleman, Frank T van Manen, Michael J Chamberlain
Anthropogenic hybridization of historically isolated taxa has become a primary conservation challenge for many imperiled species. Indeed, hybridization between red wolves ( Canis rufus ) and coyotes ( Canis latrans ) poses a significant challenge to red wolf recovery. We considered seven hypotheses to assess factors influencing hybridization between red wolves and coyotes via pair-bonding between the two species. Because long-term monogamy and defense of all-purpose territories are core characteristics of both species, mate choice has long-term consequences...
April 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29697755/the-reporting-of-blinding-in-orthodontic-randomized-controlled-trials-where-do-we-stand
#11
Salem Abdulraheem, Lars Bondemark
Objective: To analyse in 10 orthodontic journals how many randomized controlled trials (RCTs) performed 'single-', 'double-', 'triple-', or 'outcome assessors blinding' and to evaluate, from the number of RCTs that did not conduct blinding, how many could actually have achieved it. Material and methods: Randomized controlled trials published in 10 orthodontic journals between 1 September 2012 and 28 February 2018 were included. A search was performed in PubMed and conducted for publication type 'randomized controlled trial' for each journal...
April 24, 2018: European Journal of Orthodontics
https://www.readbyqxmd.com/read/29696217/quality-of-abstracts-of-pilot-trials-in-heart-failure-a-protocol-for-a-systematic-survey
#12
Godsent Isiguzo, Moleen Zunza, Maxwell Chirehwa, Bongani M Mayosi, Lehana Thabane
Introduction: Pilot trials are initial small-scale studies done to inform the design of larger trials. Their findings like other studies are usually disseminated as peer-reviewed journal articles. Abstracts are used to introduce the contents to readers, and give a general idea about the full reports and sometimes are the only source of information available to readers. Despite their importance, the contents of abstracts of trial reports are usually not informative enough and lack the essential details...
December 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29696191/the-reporting-quality-of-abstracts-of-stepped-wedge-randomized-trials-is-suboptimal-a-systematic-survey-of-the-literature
#13
REVIEW
Mei Wang, Yanling Jin, Zheng Jing Hu, Alex Thabane, Brittany Dennis, Olga Gajic-Veljanoski, James Paul, Lehana Thabane
Background: The stepped wedge trial (SWT) design is a type of the randomized clinical trial (RCT) design in which clusters or individuals are randomly and sequentially crossed over from control to intervention over a number of time periods. Trials using SWT design have become increasingly popular in medical, behavioral and social sciences research. Therefore, complete and transparent reporting of these studies is crucial. In particular, the quality of the abstracts of their reports is important because these may be the only accessible sources for their results...
December 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29696169/quality-of-abstracts-of-randomized-control-trials-in-five-top-pain-journals-a-systematic-survey
#14
Kamath Sriganesh, Suparna Bharadwaj, Mei Wang, Luciana P F Abbade, Yanling Jin, Mariamma Philip, Rachel Couban, Lawrence Mbuagbaw, Lehana Thabane
Background: The reporting quality of abstracts of randomized control trials (RCTs) is inadequate despite the publication of consolidated standards of reporting trials extension for abstracts (CONSORT-A). We compared the reporting quality of abstracts in pain journals before and after the publication of CONSORT-A. Methods: We searched MEDLINE in April-2016 for RCTs published in five pain journals: Pain, Pain Physician, European Journal of Pain, Clinical Journal of Pain and Pain Practice for pre- and post-CONSORT-A period (2005-2007 and 2013-2015)...
September 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29688827/efficacy-of-high-intensity-laser-therapy-in-treating-knee-osteoarthritis-a-first-systematic-review
#15
Justyna Wyszyńska, Monika Bal-Bocheńska
OBJECTIVE: The aim of this study was to evaluate the efficacy of high-intensity laser therapy (HILT) in the treatment of knee osteoarthritis (OA). BACKGROUND: Due to increased number of randomized controlled trials evaluating efficiency of HILT in patients with knee OA, there was a need to present them in the form of systematic review. METHODS: The search includes the databases as well as a manual search until August, 2017. The quality of the selected articles was determined in accordance with the revised guidelines of the CONSORT statement...
April 24, 2018: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29684391/a-randomized-control-trial-of-preoperative-prophylactic-antibiotics-prior-to-percutaneous-nephrolithotomy-in-low-infectious-risk-population-a-report-from-the-edge-consortium
#16
Ben H Chew, Nicole L Miller, Joel E Abbott, Dirk Lange, Mitchell R Humphreys, Vernon M Pais, Manoj Monga, Amy E Krambeck, Roger L Sur
INTRODUCTION: Single institution studies suggest a benefit of a week of preoperative antibiotics prior to percutaneous nephrolithotomy (PCNL). These studies are limited by lower quality methodology such as the inclusion of heterogeneous populations or the use of non-standard definitions of sepsis. The American Urological Association (AUA) Best Practice Statement recommends <24 hours of IV antibiotics, but no other data exist about the duration/benefit of preoperative antibiotics. We sought to perform a rigorous (using CONSORT guidelines), multi-institutional trial to assess preoperative antibiotics in PCNL patients at low risk of developing infections...
April 20, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29676976/compliance-of-randomized-clinical-trials-in-noncarious-cervical-lesions-with-the-consort-statement-a-systematic-review-of-methodology
#17
A Reis, J L de Geus, L Wambier, M Schroeder, A D Loguercio
The literature was reviewed to evaluate the compliance of randomized clinical trials (RCTs) with the CONsolidated Standards of Reporting Trials (CONSORT ) and the risk of bias of these studies through the Cochrane Collaboration risk of bias tool (CCRT). RCTs were searched at Cochrane Library, PubMed, and other electronic databases to find studies about adhesive systems for cervical lesions. The compliance of the articles with CONSORT was evaluated using the following scale: 0 = no description, 1 = poor description, and 2 = adequate description...
May 2018: Operative Dentistry
https://www.readbyqxmd.com/read/29649270/the-quality-of-reporting-in-randomized-controlled-trials-of-acupuncture-for-knee-osteoarthritis-a-cross-sectional-survey
#18
Pengli Jia, Li Tang, Jiajie Yu, Jiali Liu, Deying Kang, Xin Sun
OBJECTIVE: To assess the reporting quality of acupuncture trials for knee osteoarthritis (KOA), and explore the factors associated with the reporting. METHOD: Three English and four Chinese databases were searched from inception to December 2016 for randomized control trials testing effects of acupuncture for knee osteoarthritis. We used the standard CONSORT (2010 version), CONSORT Extension for Non-Pharmacological Treatments, and STRICTA for measuring the quality of reporting...
2018: PloS One
https://www.readbyqxmd.com/read/29648972/randomized-controlled-trials-in-adult-traumatic-brain-injury-a-systematic-review-on-the-use-and-reporting-of-clinical-outcome-assessments
#19
Lindsay Horton, Jonathan Rhodes, Lindsay Wilson
As part of efforts to improve study design, the use of outcome measures in randomized controlled trials (RCTs) in traumatic brain injury (TBI) is receiving increasing attention. This review aimed to assess how clinical outcome assessments (COAs) have been used and reported in RCTs in adult TBI. Systematic literature searches were conducted to identify medium to large (n ≥ 100) acute and post-acute TBI trials published since 2000. Data were extracted independently by two reviewers using a set of structured templates...
March 3, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29645403/quality-of-author-guidelines-in-nursing-journals
#20
Marilyn H Oermann, Leslie H Nicoll, Peggy L Chinn, Jamie L Conklin, Midori McCarty, Sathya Amarasekara
PURPOSE: The aims of this study were to (a) describe the information provided in author guidelines in nursing journals, (b) assess the completeness of this information, and (c) identify the extent and types of reporting guidelines used in nursing journals. DESIGN: Content analysis of author guidelines for 245 nursing journals included in the Directory of Nursing Journals maintained at the International Academy of Nursing Editors website. METHODS: Using Research Electronic Data Capture, data on 19 criteria for completeness were extracted from published author guidelines...
April 12, 2018: Journal of Nursing Scholarship
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