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https://www.readbyqxmd.com/read/28797065/a-systematic-review-of-the-pharmacokinetic-and-pharmacodynamic-interactions-of-herbal-medicine-with-warfarin
#1
Songie Choi, Dal-Seok Oh, Ui Min Jerng
OBJECTIVES: The aim of this study was to systematically review data regarding pharmacokinetic (PK)-pharmacodynamic (PD) parameters from randomized controlled trials relating to interactions between herbal medicines and warfarin. METHODS: Three electronic databases were searched to identify relevant trials. Two reviewers independently performed the study selection and data extraction. The risk of bias and reporting quality were also assessed independently by two reviewers using the Cochrane risk of bias tool and the consolidated standards of reporting trials (CONSORT)...
2017: PloS One
https://www.readbyqxmd.com/read/28795023/leptocarpus-disjunctus-prolongs-sleeping-time-and-increases-nonrapid-eye-movement-sleep-with-additional-anxiolytic-capacity
#2
Watchara Damjuti, Thanes Fuangfoo, Chanida Palanuvej, Tingli Li, Nijsiri Ruangrungsi
Leptocarpus disjunctus Mast. (Restionaceae) is an edible plant which has indigenous warnings regarding its side effects which can manifest as dizziness. This study investigated hypnotic and anxiolytic properties using several animal models. Anxiolytic activities were evaluated using locomotor determination by elevated plus-maze test, open-field test, and rotarod performance test. Hypnotic activities were performed using pentobarbital sodium-induced sleeping time test. Sleep architecture and quality were obtained from sleep-wake analysis and nonrapid eye movement (NREM) delta activity using electroencephalography...
July 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28782701/a-systematic-review-of-end-of-life-care-communication-skills-training-for-generalist-palliative-care-providers-research-quality-and-reporting-guidance
#3
REVIEW
Lisa Jane Brighton, Jonathan Koffman, Amy Hawkins, Christine McDonald, Suzanne O'Brien, Vicky Robinson, Shaheen A Khan, Rob George, Irene J Higginson, Lucy Ellen Selman
CONTEXT: End of life care (EoLC) communication skills training for generalist palliative care providers is recommended in policy guidance globally. Whilst many training programmes now exist, there has been no comprehensive evidence synthesis to inform future training delivery and evaluation. OBJECTIVES: To identify and appraise how EoLC communication skills training interventions for generalist palliative care providers are developed, delivered, evaluated, and reported...
August 3, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28761712/statistical-testing-of-baseline-differences-in-sports-medicine-rcts-a-systematic-evaluation
#4
REVIEW
Ross L Peterson, Matthew Tran, Jonathan Koffel, Steven D Stovitz
BACKGROUND/AIM: The CONSORT (Consolidated Standards of Reporting Trials) statement discourages reporting statistical tests of baseline differences between groups in randomised controlled trials (RCTs). However, this practice is still common in many medical fields. Our aim was to determine the prevalence of this practice in leading sports medicine journals. METHODS: We conducted a comprehensive search in Medline through PubMed to identify RCTs published in the years 2005 and 2015 from 10 high-impact sports medicine journals...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/28749016/trends-in-study-design-and-the-statistical-methods-employed-in-a-leading-general-medicine-journal
#5
M Gosho, Y Sato, K Nagashima, S Takahashi
WHAT IS KNOWN AND OBJECTIVE: Study design and statistical methods have become core components of medical research, and the methodology has become more multifaceted and complicated over time. The study of the comprehensive details and current trends of study design and statistical methods is required to support the future implementation of well-planned clinical studies providing information about evidence-based medicine. Our purpose was to illustrate study design and statistical methods employed in recent medical literature...
July 27, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28746228/randomized-noninferiority-study-between-video-versus-hand-ultrasound-with-wet-foam-dressing-materials-to-simulate-b-lines-in-lung-ultrasound-a-consort-compliant-article
#6
RANDOMIZED CONTROLLED TRIAL
Eun Jung Park, Young Tak Yoon, Chong Kun Hong, Young Rock Ha, Jung Hwan Ahn
BACKGROUND: This study evaluated the efficacy of a teaching method using simulated B-lines of hand ultrasound with a wet foam dressing material. METHODS: This prospective, randomized, noninferiority study was conducted on emergency medical technician students without any relevant training in ultrasound. Following a lecture including simulated (SG) or real video clips (RG) of B-lines, a posttest was conducted and a retention test was performed after 2 months. The test consisted of questions about B-lines in 40 randomly mixed video clips (20 simulated and 20 real videos) with 4 answer scores (R-1 [the correct answer score for the real video clips] vs S-1 [the correct answer score for the simulated video clips] in the posttest, R-2 [the correct answer score for the real video clips] vs S-2 [the correct answer score for the simulated video clips] in the retention test)...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28746180/a-consort-compliant-prospective-randomized-controlled-trial-radiation-dose-reducing-in-computed-tomography-using-an-additional-lateral-scout-view-combined-with-automatic-tube-current-modulation-phantom-and-patient-study
#7
RANDOMIZED CONTROLLED TRIAL
Wanlin Peng, Zhenlin Li, Chunchao Xia, Yingkun Guo, Jinge Zhang, Kai Zhang, Lei Li, Fei Zhao
BACKGROUND: Radiation exposure has been a hot point in research field of computed tomography (CT). Recently, automated tube current modulation (ATCM) has emerged as an important technique to reduce radiation exposure. Many studies have shown that the difference in scout view would affect modulation. This prospective randomized controlled study is aimed to investigate the impact of an additional lateral scout view on radiation dose and image quality in CT using ACTM. METHODS: Combined with ATCM (Care Dose 4D) on multidetector CT, 2 thoracic phantom CT image series were acquired in which planning was conducted with either an anteroposterior (AP) or an AP-lateral scout view...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28744879/procarbazine-lomustine-and-vincristine-for-recurrent-high-grade-glioma
#8
REVIEW
Saurabh Parasramka, Goutham Talari, Myrna Rosenfeld, Jing Guo, John L Villano
BACKGROUND: Recurrent high-grade glioma (HGG) carries an extremely poor prognosis. There is no current standard of care or guideline-based recommendations. Nitrosourea-based multidrug chemotherapy or PCV - procarbazine, lomustine (CCNU) and vincristine - is one of the treatment options at recurrence. There has been no meta-analysis which looks at the benefits and harms of PCV chemotherapy in adults with recurrent HGG. OBJECTIVES: To assess the effectiveness and safety of procarbazine, lomustine, and vincristine (PCV) chemotherapy with other interventions in adults with recurrent high-grade glioma...
July 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28738846/long-non-coding-rnas-as-novel-players-in-%C3%AE-cell-function-and-type-1-diabetes
#9
REVIEW
Aashiq H Mirza, Simranjeet Kaur, Flemming Pociot
BACKGROUND: Long non-coding RNAs (lncRNAs) are a sub-class within non-coding RNA repertoire that have emerged as crucial regulators of the gene expression in various pathophysiological conditions. lncRNAs display remarkable versatility and wield their functions through interactions with RNA, DNA, or proteins. Accumulating body of evidence based on multitude studies has highlighted the role of lncRNAs in many autoimmune and inflammatory diseases, including type 1 diabetes (T1D). This review highlights emerging roles of lncRNAs in immune and islet β cell function as well as some of the challenges and opportunities in understanding the pathogenesis of T1D and its complications...
July 24, 2017: Human Genomics
https://www.readbyqxmd.com/read/28722165/dimorphic-ejaculates-and-sperm-release-strategies-associated-with-alternative-mating-behaviors-in-the-squid
#10
Lígia H Apostólico, José E A R Marian
Sperm competition is a powerful postcopulatory selective force influencing male adaptations associated with increasing fertilization success, and it is usually related to the evolution of different strategies of ejaculate expenditure between individuals. Ejaculates may also be influenced by additional selective pressures associated with sperm competition, such as timing between insemination and fertilization, female reproductive tract morphology, and fertilization environment. Also, males that adopt alternative mating tactics may face distinct sperm competition pressures, which may lead to the evolution of intraspecific diversity in ejaculates...
July 18, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28720364/medical-expulsive-therapy-in-urolithiasis-a-review-of-the-quality-of-the-current-evidence
#11
REVIEW
Andreas Skolarikos, Khurshid R Ghani, Christian Seitz, Brandon Van Asseldonk, Matthew F Bultitude
CONTEXT: Medical expulsive therapy (MET) is widely used to promote spontaneous passage of urinary stones. However, there is conflicting evidence on the actual role of MET. OBJECTIVE: To evaluate the conformance of published randomized controlled trials (RCTs) on MET with the Consolidated Standards for Reporting Trials (CONSORT) criteria, and to clarify the current role of MET in management of urinary stones on the basis of our findings. EVIDENCE ACQUISITION: We carried out an electronic search of the Cochrane Library, PubMed, and Embase databases for RCTs on MET...
February 2017: European Urology Focus
https://www.readbyqxmd.com/read/28720094/a-literature-review-of-applied-adaptive-design-methodology-within-the-field-of-oncology-in-randomised-controlled-trials-and-a-proposed-extension-to-the-consort-guidelines
#12
Pankaj Mistry, Janet A Dunn, Andrea Marshall
BACKGROUND: The application of adaptive design methodology within a clinical trial setting is becoming increasingly popular. However the application of these methods within trials is not being reported as adaptive designs hence making it more difficult to capture the emerging use of these designs. Within this review, we aim to understand how adaptive design methodology is being reported, whether these methods are explicitly stated as an 'adaptive design' or if it has to be inferred and to identify whether these methods are applied prospectively or concurrently...
July 18, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28710065/the-limitations-of-using-randomised-controlled-trials-as-a-basis-for-developing-treatment-guidelines
#13
REVIEW
Roger Mulder, Ajeet B Singh, Amber Hamilton, Pritha Das, Tim Outhred, Grace Morris, Darryl Bassett, Bernhard T Baune, Michael Berk, Philip Boyce, Bill Lyndon, Gordon Parker, Gin S Malhi
Randomised controlled trials (RCTs) are considered the 'gold standard' by which novel psychotropic medications and psychological interventions are evaluated and consequently adopted into widespread clinical practice. However, there are some limitations to using RCTs as the basis for developing treatment guidelines. While RCTs allow researchers to determine whether a given medication or intervention is effective in a specific patient sample, for practicing clinicians it is more important to know whether it will work for their particular patient in their particular setting...
July 14, 2017: Evidence-based Mental Health
https://www.readbyqxmd.com/read/28708780/syndesmotic-ankle-fractures-a-systematic-review
#14
James D Michelson, Michael Wright, Michael Blankstein
OBJECTIVES: The diagnosis and treatment of syndesmotic ankle fractures is controversial. This systematic review was performed to clarify the current understanding addressing several clinical questions that arise in the treatment of such injuries DATA SOURCES:: The English language literature was searched using PubMed, EMBASE, and Web of Science. The search terms were "syndesmosis" or "syndesmotic" in combination with the terms "ankle fracture" or "fracture". The included dates were between 1967 and July 2015...
June 22, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28701360/multicentre-randomised-clinical-trial-of-paediatric-concussion-assessment-of-rest-and-exertion-pedcare-a-study-to-determine-when-to-resume-physical-activities-following-concussion-in-children
#15
Andrée-Anne Ledoux, Nicholas J Barrowman, Kathy Boutis, Adrienne Davis, Sarah Reid, Gurinder Sangha, Ken J Farion, Kevin Belanger, Mark S Tremblay, Keith Owen Yeates, Carol DeMatteo, Nick Reed, Roger Zemek
INTRODUCTION: Rest until symptom-free, followed by a progressive stepwise return to activities, is often prescribed in the management of paediatric concussions. Recent evidence suggests prolonged rest may hinder recovery, and early resumption of physical activity may be associated with more rapid recovery postconcussion. The primary objective is to determine whether the early reintroduction of non-contact physical activity beginning 72 hours postinjury reduces postconcussive symptoms at 2 weeks in children following an acute concussion as compared with a rest until asymptomatic protocol...
July 12, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28682863/increased-interhemispheric-resting-state-functional-connectivity-in-healthy-participants-with-insomnia-symptoms-a-randomized-clinical-consort-study
#16
RANDOMIZED CONTROLLED TRIAL
Xuhua Li, Shougang Guo, Chunjuan Wang, Baojie Wang, Hao Sun, Xiaoting Zhang
BACKGROUND: Abnormalities within the insular cortex of the salience and thalamus of the hyperarousal network have been increasingly reported in healthy participants with insomnia symptoms by recent resting-state functional magnetic resonance imaging (rsfMRI) studies. However, little is known about the changes in functional interaction between the bilateral cerebral hemispheres in healthy participants with insomnia symptoms. METHODS: In a randomized trial, 27 healthy participants with insomnia symptoms and 27 age-, gender-, and educational level-matched healthy participants without insomnia symptoms underwent rsfMRI...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28679407/protocol-for-a-systematic-review-of-n-of-1-trial-protocol-guidelines-and-protocol-reporting-guidelines
#17
Antony J Porcino, Salima Punja, An-Wen Chan, Richard Kravitz, Aaron Orkin, Philippe Ravaud, Christopher H Schmid, Sunita Vohra
BACKGROUND: N-of-1 trials are multiple cross-over trials done in individual participants, generating individual treatment effect information. While reporting guidelines for the CONSORT Extension for N-of-1 trials (CENT) and the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) already exist, there is no standardized recommendation for the reporting of N-of-1 trial protocols. OBJECTIVE: The objective of this study is to evaluate current literature on N-of-1 design and reporting to identify key elements of rigorous N-of-1 protocol design...
July 6, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28678920/pain-and-distress-outcomes-in-infants-and-children-a-systematic-review
#18
N C A C Oliveira, C M Gaspardo, M B M Linhares
The aim of the present study was to systematically review the recent literature about pain and distress outcomes in children and critically analyze the methodological quality of the reports. The systematic review was based on the PRISMA statement and performed by selecting articles that are indexed in scientific databases. The methodological quality of reports was examined using STROBE statement, for observational studies, and CONSORT statement, for randomized controlled trials. The PedIMMPACT consensus was used to evaluate the psychometric quality of pain instruments...
July 3, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28678854/randomized-blinded-trial-of-standardized-written-patient-information-before-total-knee-arthroplasty
#19
Benedicte Eschalier, Stephane Descamps, Bruno Pereira, Hélène Vaillant-Roussel, Guillaume Girard, Stephane Boisgard, Emmanuel Coudeyre
BACKGROUND: The effect of patient education before total knee arthroplasty (TKA) is controversial. No consensus exists about the optimal content of educational interventions. In a previous study, we developed and validated an educational booklet on the peri-TKA management of knee osteoarthritis. PURPOSES: Our primary purpose was to evaluate the impact of the educational booklet on knowledge among patients awaiting TKA. PATIENTS AND METHODS: This randomized controlled single-blind trial evaluated standard information by the surgeon with or without delivery of the educational booklet 4-6 weeks before primary noncomplex TKA in patients aged 55-75 years with incapacitating knee osteoarthritis...
2017: PloS One
https://www.readbyqxmd.com/read/28673865/support-for-reporting-guidelines-in-surgical-journals-needs-improvement-a-systematic-review
#20
REVIEW
Riaz A Agha, Ishani Barai, Shivanchan Rajmohan, Seon Lee, Mohammed O Anwar, Alexander J Fowler, Dennis P Orgill, Douglas G Altman
INTRODUCTION: Evidence-based medicine works best if the evidence is reported well. Past studies have shown reporting quality to be lacking in the field of surgery. Reporting guidelines are an important tool for authors to optimize the reporting of their research. The objective of this study was to analyse the frequency and strength of recommendation for such reporting guidelines within surgical journals. METHODS: A systematic review of the 198 journals within the Journal Citation Report 2014 (surgery category) published by Thomson Reuters was undertaken...
June 30, 2017: International Journal of Surgery
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