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https://www.readbyqxmd.com/read/29335051/effectiveness-of-a-preventive-recall-strategy-for-children-after-dental-rehabilitation-with-general-anesthesia
#1
Elizabeth J Berry, Tegwyn H Brickhouse, Amanda K Kerns, Katherine A Nordeen, Al M Best
PURPOSE: To test a more frequent preventive recall strategy following full-mouth dental rehabilitation (FMDR) in children with early childhood caries (ECC). METHODS: Patients were randomized into two groups: controls, who were scheduled to return at six-month intervals (6-MR); and the intervention group, who were scheduled to return at three-month intervals (3-MR and 6-MR). At baseline and at each recall, a caries risk assessment (CRA) and dental exam were completed...
November 1, 2017: Pediatric Dentistry
https://www.readbyqxmd.com/read/29332746/is-pilates-an-effective-rehabilitation-tool-a-systematic-review
#2
REVIEW
Keira Byrnes, Ping-Jung Wu, Stephney Whillier
BACKGROUND: Pilates is a system of exercise focusing upon controlled movement, stretching and breathing. Pilates is popular today not only for physical fitness but also for rehabilitation programs. This paper is a review of the literature on the effectiveness of Pilates as a rehabilitation tool in a wide range of conditions in an adult population. METHODS: A systematic literature review was carried out according to the PRISMA guidelines. Electronic databases were searched for cohort studies or randomised controlled trials (RCTs), and inclusion and exclusion criteria were applied...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29316880/structure-formats-of-randomised-controlled-trial-abstracts-a-cross-sectional-analysis-of-their-current-usage-and-association-with-methodology-reporting
#3
Fang Hua, Tanya Walsh, Anne-Marie Glenny, Helen Worthington
BACKGROUND: The reporting of randomised controlled trial (RCT) abstracts is of vital importance. The primary objective of this study was to investigate the association between structure format and RCT abstracts' quality of methodology reporting, informed by the current requirement and usage of structure formats by leading general medical/internal medicine journals (secondary objective). METHODS: A two-part cross-sectional study. First, through hand searches, we identified all RCTs published in the top-50 high-impact general medical/internal medicine journals during July-December 2015 (n = 370), and retrieved the 'instructions to authors' of these journals...
January 10, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29300977/schemata-consort-and-the-salk-polio-vaccine-trial
#4
Charles J Kowalski, Adam J Mrdjenovich
In this essay, we defend the design of the Salk polio vaccine trial and try to put some limits on the role schemata should play in designing clinical research studies. Our presentation is structured as a response to de Freitas and Pietrobon (de Freitas, R. S. and R. Pietrobon. 2007. Whoever could get rid of the context of discovery/context of justification dichotomy? A proposal based on recent developments in clinical research. Journal of Medicine and Philosophy 32:25-42.) who identified the CONSORT statement as a schema that would have, had it existed at the time, ruled out the design of the Salk polio vaccine trial of 1954 in favor of a completely randomized controlled clinical trial (RCT)...
December 29, 2017: Journal of Medicine and Philosophy
https://www.readbyqxmd.com/read/29282092/reporting-quality-of-randomized-controlled-trials-in-patients-with-hiv-on-antiretroviral-therapy-a-systematic-review
#5
REVIEW
Kaori Nagai, Akiko M Saito, Toshiki I Saito, Noriyo Kaneko
BACKGROUND: To allow for correct evaluation of clinical trial results, readers require comprehensive, clear, and highly transparent information on the methodology used and the results obtained. This study aimed to evaluate the quality of reporting in articles on randomized controlled trials (RCTs) of antiretroviral therapy (ART) in the field of HIV/AIDS. METHODS: We searched for original articles on RCTs of ART developed in the field of HIV/AIDS in PubMed database by 5 April 2016...
December 28, 2017: Trials
https://www.readbyqxmd.com/read/29277947/parental-involvement-in-adolescent-depression-interventions-a-systematic-review-of-randomized-clinical-trials
#6
REVIEW
Latefa Ali Dardas, Brittney van de Water, Leigh Ann Simmons
Despite the widespread research recommendations for psychiatric nurses and other mental health professionals to include parents in adolescent depression treatment, no systematic reviews have yet synthesized the findings from intervention studies that included parents in the treatment and/or prevention of adolescent depression. Therefore, this systematic review was conducted to (i) identify and describe clinical trials that included parents as an integral component of adolescent depression interventions, (ii) examine the effectiveness of these trials in reducing depressive symptoms, and (iii) evaluate their methodological quality...
December 25, 2017: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29277558/the-cohort-multiple-randomised-controlled-trial-cmrcts-design-was-found-to-be-highly-susceptible-to-low-statistical-power-and-internal-validity-biases
#7
David Reeves, Kelly Howells, Mark Sidaway, Amy Blakemore, Mark Hann, Maria Panagioti, Peter Bower
OBJECTIVE: The 'cohort multiple randomized controlled trial' (cmRCT) is a recent innovation by which novel interventions are trialled within large longitudinal cohorts of patients to take gain efficiencies and align trials more closely to standard clinical practice. The use of cmRCTs is outpacing methodological understanding of them and more appropriate methods for designing and analysing such trials are urgently needed. STUDY DESIGN AND SETTING: We established the UK CLASSIC cohort of 4,377 patients with long-term conditions within which we are conducting a cmRCT ("PROTECTS") of telephone-based health coaching...
December 19, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29260229/guidelines-for-the-content-of-statistical-analysis-plans-in-clinical-trials
#8
Carrol Gamble, Ashma Krishan, Deborah Stocken, Steff Lewis, Edmund Juszczak, Caroline Doré, Paula R Williamson, Douglas G Altman, Alan Montgomery, Pilar Lim, Jesse Berlin, Stephen Senn, Simon Day, Yolanda Barbachano, Elizabeth Loder
Importance: While guidance on statistical principles for clinical trials exists, there is an absence of guidance covering the required content of statistical analysis plans (SAPs) to support transparency and reproducibility. Objective: To develop recommendations for a minimum set of items that should be addressed in SAPs for clinical trials, developed with input from statisticians, previous guideline authors, journal editors, regulators, and funders. Design: Funders and regulators (n = 39) of randomized trials were contacted and the literature was searched to identify existing guidance; a survey of current practice was conducted across the network of UK Clinical Research Collaboration-registered trial units (n = 46, 1 unit had 2 responders) and a Delphi survey (n = 73 invited participants) was conducted to establish consensus on SAPs...
December 19, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29251738/nm23-proteins-innocent-bystanders-or-local-energy-boosters-for-cftr
#9
Richmond Muimo, Hani Mm Alothaid, Anil Mehta
NM23 proteins NDPK-A and -B bind to the cystic fibrosis (CF) protein CFTR in different ways from kinases such as PKA, CK2 and AMPK or linkers to cell calcium such as calmodulin and annexins. NDPK-A (not -B) interacts with CFTR through reciprocal AMPK binding/control, whereas NDPK-B (not -A) binds directly to CFTR. NDPK-B can activate G proteins without ligand-receptor coupling, so perhaps NDPK-B's binding influences energy supply local to a nucleotide-binding site (NBD1) needed for CFTR to function. Curiously, CFTR (ABC-C7) is a member of the ATP-binding cassette (ABC) protein family that does not obey 'clan rules'; CFTR channels anions and is not a pump, regulates disparate processes, is itself regulated by multiple means and is so pleiotropic that it acts as a hub that orchestrates calcium signaling through its consorts such as calmodulin/annexins...
December 18, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29247107/low-dose-glucocorticoids-plus-rituximab-versus-high-dose-glucocorticoids-plus-rituximab-for-remission-induction-in-anca-associated-vasculitis-lovas-protocol-for-a-multicentre-open-label-randomised-controlled-trial
#10
Shunsuke Furuta, Takao Sugiyama, Takeshi Umibe, Yuko Kaneko, Koichi Amano, Kazuhiro Kurasawa, Daiki Nakagomi, Masaki Hiraguri, Hideki Hanaoka, Yasunori Sato, Kei Ikeda, Hiroshi Nakajima
INTRODUCTION: Antineutrophil cytoplasm antibody-associated vasculitis (AAV) is a form of systemic vasculitis. The current standard induction therapy with the combination of high-dose glucocorticoids and cyclophosphamide or rituximab has high remission rates of 80%-90%. However, it is also associated with various side effects, including death due to infection or cardiovascular disease. There is an unmet medical need of a new therapy to reduce side effects. METHODS AND ANALYSIS: This is a phase IV multicentre, open-label, randomised controlled trial that aims to evaluate the efficacy and safety of a new remission induction regimen with the combination of low-dose glucocorticoids and rituximab...
December 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29231552/-analyzation-of-expressive-elements-for-clinical-rct-of-acupuncture-and-moxibustion-taking-peptic-ulcer-as-an-example
#11
Xing Meng, Shulan Qi, Yi Zeng
To explore the expressive elements for the clinical randomized controlled trials of acupuncture and moxibustion so as to provide reference for them, taking peptic ulcer as an example. Sixty-six papers from 1996 to 2015 were collected in domestic and overseas databases, including China National Knowledge Infrastructure (CNKI), WANFANG, VIP, China Biology Medicine (CBM), PubMed, Web of Science, Sciencedirect, Springer, Wiley. The expression qualities were evaluated according to the Consolidated Standards of Reporting Trials (CONSORT) and the Standards for Reporting Interventions in Clinical Trials of Acupuncture(STRICTA)...
July 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29230680/structured-reporting-for-fibrosing-lung-disease-a-model-shared-by-radiologist-and-pulmonologist
#12
Nicola Sverzellati, Anna Odone, Mario Silva, Roberta Polverosi, Carlo Florio, Luciano Cardinale, Giancarlo Cortese, Giancarlo Addonisio, Maurizio Zompatori, Giorgia Dalpiaz, Sara Piciucchi, Anna Rita Larici
OBJECTIVES: To apply the Delphi exercise with iterative involvement of radiologists and pulmonologists with the aim of defining a structured reporting template for high-resolution computed tomography (HRCT) of patients with fibrosing lung disease (FLD). METHODS: The writing committee selected the HRCT criteria-the Delphi items-for rating from both radiology panelists (RP) and pulmonology panelists (PP). The Delphi items were first rated by RPs as "essential", "optional", or "not relevant"...
December 11, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/29221458/a-cohort-examination-to-establish-reporting-of-the-remit-and-function-of-trial-steering-committees-in-randomised-controlled-trials
#13
Elizabeth J Conroy, Barbara Arch, Nicola L Harman, J Athene Lane, Steff C Lewis, John Norrie, Matthew R Sydes, Carrol Gamble
BACKGROUND: The DAMOCLES project established a widely used Data Monitoring Committee (DMC) Charter for randomised controlled trials (RCTs). Typically, within the UK, the DMC is advisory and recommends to another executive body; the Trial Steering Committee (TSC). Despite the executive role of the TSC, the CONSORT Statement does not explicitly require reporting of TSC activity, although is included as an example of good reporting. A lack of guidance on TSC reporting can impact transparency of trial oversight, ultimately leading to a misunderstanding regarding role and, subsequently, further variation in practice...
December 8, 2017: Trials
https://www.readbyqxmd.com/read/29218501/evaluating-safety-reporting-in-paediatric-antibiotic-trials-2000-2016-a-systematic-review-and-meta-analysis
#14
REVIEW
Paola Pansa, Yingfen Hsia, Julia Bielicki, Irja Lutsar, A Sarah Walker, Mike Sharland, Laura Folgori
BACKGROUND: There are very few options to treat multidrug-resistant bacterial infections in children. A major barrier is the duration and complexity of regulatory trials of new antibiotics. Extrapolation of safety data from adult trials could facilitate drug development for children. OBJECTIVE: We performed a systematic review on the safety of antibiotic clinical trials (CTs) in children (0-18 years) to evaluate the overall quality of safety trials conducted in children and to determine if age-specific adverse events (AEs) could be identified for specific antibiotic classes...
December 7, 2017: Drugs
https://www.readbyqxmd.com/read/29187157/consort-to-community-translation-of-an-rct-to-a-large-scale-community-intervention-and-learnings-from-evaluation-of-the-upscaled-program
#15
Carly Jane Moores, Jacqueline Miller, Rebecca Anne Perry, Lily Lai Hang Chan, Lynne Allison Daniels, Helen Anna Vidgen, Anthea Margaret Magarey
BACKGROUND: Translation encompasses the continuum from clinical efficacy to widespread adoption within the healthcare service and ultimately routine clinical practice. The Parenting, Eating and Activity for Child Health (PEACH™) program has previously demonstrated clinical effectiveness in the management of child obesity, and has been recently implemented as a large-scale community intervention in Queensland, Australia. This paper aims to describe the translation of the evaluation framework from a randomised controlled trial (RCT) to large-scale community intervention (PEACH™ QLD)...
November 29, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29186478/randomized-controlled-trials-in-children-s-heart-surgery-in-the-21st-century-a-systematic-review
#16
Nigel E Drury, Akshay J Patel, Nicola K Oswald, Cher-Rin Chong, John Stickley, David J Barron, Timothy J Jones
OBJECTIVES: Randomized controlled trials are the gold standard for evaluating health care interventions, yet are uncommon in children's heart surgery. We conducted a systematic review of clinical trials in paediatric cardiac surgery to evaluate the scope and quality of the current international literature. METHODS: We searched MEDLINE, CENTRAL and LILACS, and manually screened retrieved references and systematic reviews to identify all randomized controlled trials reporting the effect of any intervention on the conduct or outcomes of heart surgery in children published in any language since January 2000; secondary publications and those reporting inseparable adult data were excluded...
November 23, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29184261/adherence-to-the-consort-statement-in-the-reporting-of-randomized-controlled-trials-on-pharmacological-interventions-published-in-iranian-medical-journals
#17
Pooneh Sarveravan, Behrooz Astaneh, Nasrin Shokrpour
Background: Among manuscripts submitted to biomedical journals, randomized controlled trials (RCTs) form the backbone of evidence-based medicine. Hence, their protocol should be designed rigorously and their results should be reported clearly. To improve the quality of RCT reporting, researchers developed the CONSORT Statement in 1996 and updated it in 2010. This study was designed to assess the quality of RCT reporting vis-à-vis adherence to CONSORT among articles published in Iranian medical journals (English, Persian, CONSORT-endorsing, and non-CONSORT-endorsing)...
November 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29179761/efficacy-and-safety-of-the-xingnao-kaiqiao-acupuncture-technique-via-intradermal-needling-to-treat-postoperative-gastrointestinal-dysfunction-of-laparoscopic-surgery-study-protocol-for-a-randomized-controlled-trial
#18
Wenli Zhao, Jinting Li, Yuling Wang, Jing Liu, Ying Chen, Guang Zhao, Ye Zhao, Huaien Bu, Yiider Tseng, Xuemin Shi
BACKGROUND: Xingnao Kaiqiao acupuncture involves needling of the Neiguan (PC6), Renzhong (DU26), and Sanyinjiao (SP6) acupoints. The technique has a significant clinical effect in many neurological diseases. In the present report, we have developed a protocol for a scientific trial to analyze whether Xingnao Kaiqiao can be used to treat gastrointestinal dysfunction after laparoscopic surgery. In this context, we intend to execute a double-blind, randomized controlled trial to assess the efficacy and safety of Xingnao Kaiqiao acupuncture via intradermal needling...
November 28, 2017: Trials
https://www.readbyqxmd.com/read/29177062/validity-of-studies-suggesting-postsurgical-chemotherapy-for-resectable-gastric-cancer-critical-appraisal-of-randomised-trials
#19
Giulia Manzini, Doris Henne-Bruns, Michael Kremer
Background and aim: In 2013, Diaz-Nieto et al published a Cochrane review to summarise the impact of postsurgical chemotherapy versus surgery alone on survival for resectable gastric cancer. The authors concluded that postsurgical chemotherapy showed an improvement in overall survival. The aim of this article was to assess the validity of four studies included in the Cochrane review and to investigate the impact of an exclusion of these four studies on the result of the meta-analysis...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29171120/quality-of-development-and-reporting-of-dietetic-intervention-studies-in-primary-care-a-systematic-review-of-randomised-controlled-trials
#20
REVIEW
L E Ball, I K Sladdin, L J Mitchell, K A Barnes, L J Ross, L T Williams
BACKGROUND: High-quality research methodologies and clear reporting of studies are essential to facilitate confidence in research findings. The aim of the present study was to conduct an in-depth examination of the methodological quality and reporting of studies included in a recent systematic review of dietitians' effectiveness at providing individualised nutrition care to adult patients. METHODS: The methodological quality and reporting of 27 Randomised Controlled Trials (RCTs) were appraised using the UK Medical Research Council (MRC) Guidelines for complex interventions and the CONSORT checklist for reporting RCTs...
November 24, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
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