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https://www.readbyqxmd.com/read/27918069/quality-of-reporting-in-surgical-randomized-clinical-trials
#1
J Yu, X Li, Y Li, X Sun
BACKGROUND: RCTs testing surgical interventions can change clinical practice. The adequate reporting of surgical trials is an important issue. METHODS: A cross-sectional survey was undertaken by searching PubMed for two-arm parallel randomized trials assessing surgical interventions published in 2003 or 2013. Quality of reporting was evaluated against the CONSORT checklist containing 29 items (standard CONSORT plus CONSORT Extension for Trials Assessing Non-Pharmacological Treatments)...
December 5, 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/27915997/taking-advantage-of-unexpected-webconsort-results
#2
EDITORIAL
Erik Cobo, José Antonio González
To estimate treatment effects, trials are initiated by randomising patients to the interventions under study and finish by comparing patient evolution. In order to improve the trial report, the CONSORT statement provides authors and peer reviewers with a guide of the essential items that would allow research replication. Additionally, WebCONSORT aims to facilitate author reporting by providing the items from the different CONSORT extensions that are relevant to the trial being reported. WebCONSORT has been estimated to improve the proportion of reported items by 0...
December 5, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27915306/a-consort-analysis-of-randomised-controlled-trials-for-the-treatment-of-invasive-aspergillosis
#3
Brian L Jones, Malcolm D Richardson, Patricia M Ingram, Samir G Agrawal
There is no assessment of the reporting quality of antifungal randomized, controlled trials (RCT), upon which guidelines for the treatment of invasive aspergillosis (IA) in patients with hematological malignancy are based. Trial reports were identified through Trip, Cochrane, Medline, and Embase database searches. Report quality was assessed using the 25-item CONSORT checklist and a rating scale of 1 (strongly disagree) to 4 (strongly agree). The primary endpoint was quality as assessed by mean group-scores among papers published at the time of the most recent IA treatment guidelines...
December 3, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27902731/queen-nefertari-the-royal-spouse-of-pharaoh-ramses-ii-a-multidisciplinary-investigation-of-the-mummified-remains-found-in-her-tomb-qv66
#4
Michael E Habicht, Raffaella Bianucci, Stephen A Buckley, Joann Fletcher, Abigail S Bouwman, Lena M Öhrström, Roger Seiler, Francesco M Galassi, Irka Hajdas, Eleni Vassilika, Thomas Böni, Maciej Henneberg, Frank J Rühli
Queen Nefertari, the favourite Royal Consort of Pharaoh Ramses II (Ancient Egypt, New Kingdom, 19th Dynasty c. 1250 BC) is famous for her beautifully decorated tomb in the Valley of the Queens. Her burial was plundered in ancient times yet still many objects were found broken in the debris when the tomb was excavated. Amongst the found objects was a pair of mummified legs. They came to the Egyptian Museum in Turin and are henceforth regarded as the remains of this famous Queen, although they were never scientifically investigated...
2016: PloS One
https://www.readbyqxmd.com/read/27894295/impact-of-a-web-based-tool-webconsort-to-improve-the-reporting-of-randomised-trials-results-of-a-randomised-controlled-trial
#5
Sally Hopewell, Isabelle Boutron, Douglas G Altman, Ginny Barbour, David Moher, Victor Montori, David Schriger, Jonathan Cook, Stephen Gerry, Omar Omar, Peter Dutton, Corran Roberts, Eleni Frangou, Lei Clifton, Virginia Chiocchia, Ines Rombach, Karolina Wartolowska, Philippe Ravaud
BACKGROUND: The CONSORT Statement is an evidence-informed guideline for reporting randomised controlled trials. A number of extensions have been developed that specify additional information to report for more complex trials. The aim of this study was to evaluate the impact of using a simple web-based tool (WebCONSORT, which incorporates a number of different CONSORT extensions) on the completeness of reporting of randomised trials published in biomedical publications. METHODS: We conducted a parallel group randomised trial...
November 28, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27893688/identification-of-genes-and-signaling-pathways-associated-with-diabetic-neuropathy-using-a-weighted-correlation-network-analysis-a-consort-study
#6
Ya Li, Weiguo Ma, Chuanqing Xie, Min Zhang, Xiaohong Yin, Fenfen Wang, Jie Xu, Bingyin Shi
BACKGROUND: The molecular mechanisms behind diabetic neuropathy remains to be investigated. METHODS: This is a secondary study on microarray dataset (GSE24290) downloaded from Gene Expression Omnibus (GEO) at the National Center for Biotechnology Information (NCBI), which included 18 nerve tissue samples of progressing diabetic neuropathy (fibers loss ≥500 fibers/mm) and 17 nerve tissue samples of nonprogressing diabetic neuropathy (fibers loss ≤100 fibers/mm)...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27890023/progressive-muscle-relaxation-as-a-supportive-intervention-for-cancer-patients-undergoing-chemotherapy-a-systematic-review
#7
Panagiotis Pelekasis, Ifigeneia Matsouka, Anna Koumarianou
BACKGROUND: Many cancer patients use a wide variety of techniques to improve their physical and mental well-being, including relaxation therapy and, specifically, Progressive Muscle Relaxation (PMR). However, there is no strong evidence that supports the efficacy of this technique. OBJECTIVE: Our aim was to review the evidence regarding the use of PMR as a supportive intervention for cancer patients undergoing chemotherapeutic treatment. METHOD: Six databases were electronically searched: AMED, the Cochrane Library, MEDLINE, PsychINFO, Scopus, and the Web of Science...
November 28, 2016: Palliative & Supportive Care
https://www.readbyqxmd.com/read/27881175/do-emergency-medicine-journals-promote-trial-registration-and-adherence-to-reporting-guidelines-a-survey-of-instructions-for-authors
#8
Matthew T Sims, Nolan M Henning, C Cole Wayant, Matt Vassar
BACKGROUND: The aim of this study was to evaluate the current state of two publication practices, reporting guidelines requirements and clinical trial registration requirements, by analyzing the "Instructions for Authors" of emergency medicine journals. METHODS: We performed a web-based data abstraction from the "Instructions for Authors" of the 27 Emergency Medicine journals catalogued in the Expanded Science Citation Index of the 2014 Journal Citation Reports and Google Scholar Metrics h5-index to identify whether each journal required, recommended, or made no mention of the following reporting guidelines: EQUATOR Network, ICMJE, ARRIVE, CARE, CONSORT, STARD, TRIPOD, CHEERS, MOOSE, STROBE, COREQ, SRQR, SQUIRE, PRISMA-P, SPIRIT, PRISMA, and QUOROM...
November 24, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/27879522/a-systematic-review-of-completeness-of-reporting-in-randomized-controlled-trials-in-dermatologic-surgery-adherence-to-consort-2010-recommendations
#9
Murad Alam, Mutahir Rauf, Sana Ali, Parth Patel, Daniel I Schlessinger, Matthew R Schaeffer, Simon S Yoo, Kira Minkis, Shang I Brian Jiang, Ian A Maher, Joseph F Sobanko, Todd V Cartee, Emily Poon
BACKGROUND: Randomized controlled trials are the gold standard for comparing safety and effectiveness of surgical interventions. Reporting guidelines are available for conveying the results of such trials. OBJECTIVE: To assess adherence to standard reporting guidelines among randomized controlled trials in dermatologic surgery. MATERIALS AND METHODS: Systematic review. Data source was randomized controlled trials in the journal Dermatologic Surgery, per PubMed search, 1995 to 2014...
December 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27872116/reporting-quality-of-abstracts-of-trials-published-in-top-five-pain-journals-a-protocol-for-a-systematic-survey
#10
Kamath Sriganesh, Suparna Bharadwaj, Mei Wang, Luciana P F Abbade, Rachel Couban, Lawrence Mbuagbaw, Lehana Thabane
INTRODUCTION: Abstracts of randomised controlled trials (RCTs) are often the first and the only source read in a journal by busy healthcare providers. This necessitates good reporting of abstracts. The quality of reporting of abstracts, though gradually improving over time, is still not uniform across medical journals. Improvement in completeness of reporting of abstracts has been documented in general medical journals after the publication of the consolidated standards of reporting trials (CONSORT) extension for abstracts in 2008...
November 21, 2016: BMJ Open
https://www.readbyqxmd.com/read/27855103/hyaluronic-acid-binding-sperm-selection-for-assisted-reproduction-treatment-habselect-study-protocol-for-a-multicentre-randomised-controlled-trial
#11
K D Witt, L Beresford, S Bhattacharya, K Brian, A Coomarasamy, R Hooper, J Kirkman-Brown, Y Khalaf, S E Lewis, A Pacey, S Pavitt, R West, D Miller
INTRODUCTION: The selection of a sperm with good genomic integrity is an important consideration for improving intracytoplasmic sperm injection (ICSI) outcome. Current convention selects sperm by vigour and morphology, but preliminary evidence suggests selection based on hyaluronic acid binding may be beneficial. The aim of the Hyaluronic Acid Binding Sperm Selection (HABSelect) trial is to determine the efficacy of hyaluronic acid (HA)-selection of sperm versus conventionally selected sperm prior to ICSI on live birth rate (LBR)...
October 7, 2016: BMJ Open
https://www.readbyqxmd.com/read/27836815/overcoming-perfectionism-protocol-of-a-randomized-controlled-trial-of-an-internet-based-guided-self-help-cognitive-behavioral-therapy-intervention
#12
Radha Kothari, Sarah Egan, Tracey Wade, Gerhard Andersson, Roz Shafran
BACKGROUND: Perfectionism is elevated across, and increases risk for, a range of psychological disorders as well as having a direct negative effect on day-to-day function. A growing body of evidence shows that cognitive behavioral therapy (CBT) reduces perfectionism and psychological disorders, with medium to large effect sizes. Given the increased desire for Web-based interventions to facilitate access to evidence-based therapy, Internet-based CBT self-help interventions for perfectionism have been designed...
November 11, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27829675/guidelines-consort-statement-extended-for-pilot-trials
#13
Jessica McHugh
No abstract text is available yet for this article.
November 10, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27829392/illness-management-recovery-imr-in-the-netherlands-a-naturalistic-pilot-study-to-explore-the-feasibility-of-a-randomized-controlled-trial
#14
Bert-Jan Roosenschoon, Jaap van Weeghel, Moniek Bogaards, Mathijs L Deen, Cornelis L Mulder
BACKGROUND: Illness Management & Recovery (IMR) is a curriculum-based program for people with severe and persistent mental illness. To date, four randomized controlled trials (RCTs) have been published on it. As these produced mixed results, we conducted a pilot study to test the feasibility of conducting a new RCT in a Dutch psychiatric institute. Because our primary objective was to evaluate support for implementing IMR on a broader scale, we examined participant recruitment, client outcomes, and clients' and clinicians' satisfaction...
November 9, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27814837/to-screen-or-not-to-screen-reconciling-individual-and-population-perspectives-on-screening
#15
REVIEW
L Rachid Salmi, Gaëlle Coureau, Marion Bailhache, Simone Mathoulin-Pélissier
Screening is the early detection of a latent disorder by a test to allow early intervention with the aim of improving prognosis. Individual and population perspectives on screening are perceived as opposing interests of patients and the population. In this article, we try to reconcile these perspectives. The individual perspective is based on the clinical experience of a better prognosis at early stages and patients with missed opportunities. In the population perspective, screening is based on a population-oriented, evidence-based model and addresses the acceptability and possible negative effects, including for people without the disorder...
November 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27813667/neuropeptides-as-regulators-of-behavior-in-insects
#16
Liliane Schoofs, Arnold De Loof, Matthias Boris Van Hiel
Neuropeptides are by far the largest and most diverse group of signaling molecules in multicellular organisms. They are ancient molecules important in regulating a multitude of processes. Their small proteinaceous character allowed them to evolve and radiate quickly into numerous different molecules. On average, hundreds of distinct neuropeptides are present in animals, sometimes with unique classes that do not occur in distantly related species. Acting as neurotransmitters, neuromodulators, hormones, or growth factors, they are extremely diverse and are involved in controlling growth, development, ecdysis, digestion, diuresis, and many more physiological processes...
October 28, 2016: Annual Review of Entomology
https://www.readbyqxmd.com/read/27805791/a-double-blind-randomised-controlled-trial-of-collagen-mesh-for-the-prevention-of-abdominal-incisional-hernia-in-patients-having-a-vertical-rectus-abdominis-myocutaneus-vram-flap-during-surgery-for-advanced-pelvic-malignancy
#17
Alexander Risskov Mortensen, Irene Grossmann, Mona Rosenkilde, Pål Wara, Søren Laurberg, Peter Christensen
AIM: The study investigated the effect of collagen mesh-assisted closure at the donor site in preventating the formation of incisional hernia following a vertical rectus abdominis myocutaneus (VRAM) flap as part of pelvic surgery for recurrent colorectal cancer.. METHOD: The study was a double blinded randomised controlled superiority trial performed designed according to the Consort Statement. Eligible patients undergoing surgery for advanced colorectal pelvic malignancy including a VRAM flap were prospectively randomised to conventional abdominal wound closure or collagen mesh-assisted closure...
November 2, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27798013/safety-and-immunogenicity-of-a-new-13-valent-pneumococcal-conjugate-vaccine-versus-a-licensed-7-valent-pneumococcal-conjugate-vaccine-a-study-protocol-of-a-randomised-non-inferiority-trial-in-china
#18
Jing Jing Chen, Lin Yuan, Zhen Huang, Nian Min Shi, Yu Liang Zhao, Sheng Li Xia, Guo Hua Li, Rong Cheng Li, Yan Ping Li, Shu Yuan Yang, Jie Lai Xia
INTRODUCTION: The invasive pneumococcal diseases (IPDs) caused by Streptococcus pneumoniae pose an enormous threat to children under 5 years of age. However, routine use of pneumococcal conjugate vaccines could aid in reducing the incidence of IPDs. The purpose of this clinical trial is to assess the non-inferiority of the investigational 13-valent pneumococcal conjugate vaccine (PCV13) to the currently licensed 7-valent pneumococcal conjugate vaccine (PCV7). METHODS AND ANALYSIS: 1040 infants will receive a three-dose series of either PCV13 or PCV7 at ages 3, 4 and 5 months, respectively, and a booster dose at 12-15 months...
October 19, 2016: BMJ Open
https://www.readbyqxmd.com/read/27789302/management-of-overactive-bladder-with-onabotulinumtoxina-systematic-review-and-meta-analysis
#19
Hugo E López Ramos, Lynda Torres Castellanos, Ingrid Ponce Esparza, Alejandro Jaramillo, Andrea Rodríguez, Camila Moreno Bencardino
OBJECTIVE: To evaluate the efficacy and safety of OnabotulinumtoxinA treatment in the management of overactive bladder syndrome. MATERIALS AND METHODS: A systematic review of the literature and meta-analysis was performed including randomized controlled clinical trials that compared the use of OnabotulinumtoxinA with placebo, antimuscarinic medication, or different doses of OnabotulinumtoxinA. Eleven studies met inclusion criteria and did not have any exclusion criteria...
October 24, 2016: Urology
https://www.readbyqxmd.com/read/27779896/design-and-rationale-of-the-reevaluation-of-systemic-early-neuromuscular-blockade-rose-trial-for-acute-respiratory-distress-syndrome
#20
David T Huang, Derek C Angus, Marc Moss, B Taylor Thompson, Niall D Ferguson, Adit Ginde, Michelle Ng Gong, Stephanie Gundel, Douglas L Hayden, R Duncan Hite, Peter C Hou, Catherine L Hough, Theodore J Iwashyna, Kathleen D Liu, Daniel S Talmor, Donald M Yealy
The Reevaluation Of Systemic Early neuromuscular blockade trial (ROSE) is a multicenter randomized trial designed to assess the efficacy and safety of early neuromuscular blockade in patients with moderate to severe acute respiratory distress syndrome. This document provides background for interpretation of the trial results, and highlights unique design approaches that may inform future trials of acute illness. We describe the process by which ROSE was chosen as the inaugural trial of the multidisciplinary Prevention and Early Treatment of Acute Lung Injury (PETAL) Network, provide the trial methodology using the Consolidated Standards of Reporting Trials (CONSORT) framework, and discuss key design challenges and their resolution...
October 25, 2016: Annals of the American Thoracic Society
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