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https://www.readbyqxmd.com/read/28098954/use-of-play-therapy-in-nursing-process-a-prospective-randomized-controlled-study
#1
Emel Sezici, Ayse Ferda Ocakci, Hasibe Kadioglu
PURPOSE: Play therapy is a nursing intervention employed in multidisciplinary approaches to develop the social, emotional, and behavioral skills of children. In this study, we aim to determine the effects of play therapy on the social, emotional, and behavioral skills of pre-school children through the nursing process. DESIGN: A single-blind, prospective, randomized controlled study was undertaken. The design, conduct, and reporting of this study adhere to the Consolidated Standards of Reporting Trials (CONSORT) guidelines...
January 18, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28093264/consort-guidelines-for-non-inferiority-trials-going-beyond-the-absolute-risk-difference
#2
Walter Palmas
No abstract text is available yet for this article.
January 13, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28093238/a-model-of-the-mitochondrial-basis-of-bipolar-disorder
#3
REVIEW
Gerwyn Morris, Ken Walder, Sean L McGee, Olivia M Dean, Susannah J Tye, Michael Maes, Michael Berk
BACKGROUND: Bipolar disorder phenomenologically is a biphasic disorder of energy availability; increased in mania and decreased in depression. In consort, there is accumulating evidence indicating increased mitochondrial respiration and ATP production in bipolar mania which contrasts with decreased mitochondrial function in patients in the euthymic or depressive phase of the illness. Consequently, the central thesis of this paper is that bipolar disorder is due to a phasic dysregulation of mitochondrial biogenergetics...
January 13, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28073101/impact-of-targeted-therapies-in-metastatic-renal-cell-carcinoma-on-patient-reported-outcomes-methodology-of-clinical-trials-and-clinical-benefit
#4
REVIEW
M Dos Santos, P E Brachet, C Chevreau, F Joly
BACKGROUND: Molecular targeted therapies have improved progression-free survival (PFS) without translating systematically into overall survival (OS) for patients with metastatic renal cell carcinoma (mRCC). In this population, patient-reported outcomes (PROs) have become a significant outcome. We evaluated the methodological quality of the assessment of PROs in randomized controlled trials (RCTs) and the clinical benefit of the different treatments including survival and quality of life (QoL)...
December 30, 2016: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28039682/citicoline-for-traumatic-brain-injury-a-systematic-review-meta-analysis
#5
Ali Meshkini, Mohammad Meshkini, Homayoun Sadeghi-Bazargani
BACKGROUND: Traumatic Brain Injury (TBI) is the leading cause of mortality and morbidity especially in young ages. Despite over 30 years of using Neuroprotective agents for TBI management, there is no absolute recommended agent for the condition yet. METHODS: This study is a part of a scoping review thesis on "Neuroprotective agents using for Traumatic Brain Injury: a systematic review & meta-analyses", which had a wide proposal keywords and ran in "Cochrane CENTRAL", "MedLine/PubMed", "SCOPUS", "Thomson Reuters Web of Science", "SID...
January 1, 2017: Journal of Injury & Violence Research
https://www.readbyqxmd.com/read/28002316/comparative-study-between-2-different-doses-of-pregabalin-and-lidocaine-on-pain-following-propofol-injection-a-double-blind-randomized-clinical-consort-study
#6
Eunkyung Choi, Donggyeong Kim, Younghoon Jeon
BACKGROUND: Propofol, an intravenous anesthetic, often causes pain on injection, which can be very distressful to patients. We investigated the analgesic effect of pregabalin on pain following propofol injection, compared with lidocaine. METHODS: In a randomized, double-blind, prospective trial, 120 patients were randomized into 3 groups of 40 each; who received oral placebo and intravenous lidocaine 40 mg with venous occlusion for 1 minute (group L, n = 40), oral pregabalin 75 mg and intravenous normal saline with venous occlusion for 1 minute (group LP, n = 40), and oral pregabalin 150 mg and intravenous normal saline with venous occlusion for 1 minute (group HP, n = 40) as pretreatment, followed by administration of 1% propofol 0...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27998900/randomised-double-blind-placebo-controlled-study-investigating-the-effects-of-inorganic-nitrate-on-vascular-function-platelet-reactivity-and-restenosis-in-stable-angina-protocol-of-the-nitrate-oct-study
#7
Krishnaraj S Rathod, Daniel A Jones, T J A Van-Eijl, Hilda Tsang, Helen Warren, Stephen M Hamshere, Vikas Kapil, Ajay K Jain, Andrew Deaner, Neil Poulter, Mark J Caulfield, Anthony Mathur, Amrita Ahluwalia
INTRODUCTION: The mainstay treatment for reducing the symptoms of angina and long-term risk of heart attacks in patients with heart disease is stent implantation in the diseased coronary artery. While this procedure has revolutionised treatment, the incidence of secondary events remains a concern. These repeat events are thought to be due, in part, to continued enhanced platelet reactivity, endothelial dysfunction and ultimately restenosis of the stented artery. In this study, we will investigate whether a once a day inorganic nitrate administration might favourably modulate platelet reactivity and endothelial function leading to a decrease in restenosis...
December 20, 2016: BMJ Open
https://www.readbyqxmd.com/read/27993941/scoping-systematic-review-on-the-extent-nature-and-quality-of-evidence-underlying-ophthalmic-and-paraophthalmic-education
#8
REVIEW
Michael Williams, Mairead Boohan, Allen Thurston
BACKGROUND: Effective education of relevant professionals underpins provision of quality eye healthcare. OBJECTIVES: This scoping systematic review had 2 aims: first to investigate the extent and nature of scholarly output published on ophthalmic and paraophthalmic education, and second to focus on the quality of reporting of randomised controlled trials (RCTs) identified. STUDY SELECTION: A search strategy was created and applied to PubMed...
December 19, 2016: Evidence-based Medicine
https://www.readbyqxmd.com/read/27981660/reporting-quality-and-risk-of-bias-in-randomised-trials-in-health-professions-education
#9
Tanya Horsley, James Galipeau, Jennifer Petkovic, Jeanie Zeiter, Stanley J Hamstra, David A Cook
CONTEXT: Complete reporting of research is essential to enable consumers to accurately appraise, interpret and apply findings. Quality appraisal checklists are giving way to tools that judge the risk for bias. OBJECTIVES: We sought to determine the prevalence of these complementary aspects of research reports (completeness of reporting and perceived risk for bias) of randomised studies in health professions education. METHODS: We searched bibliographic databases for randomised studies of health professions education...
January 2017: Medical Education
https://www.readbyqxmd.com/read/27976755/erratum-to-methods-and-processes-for-development-of-a-consort-extension-for-reporting-pilot-randomized-controlled-trials
#10
Lehana Thabane, Sally Hopewell, Gillian A Lancaster, Christine M Bond, Claire L Coleman, Michael J Campbell, Sandra M Eldridge
[This corrects the article DOI: 10.1186/s40814-016-0065-z.].
2016: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/27974062/interventions-to-reduce-the-impact-of-unemployment-and-economic-hardship-on-mental-health-in-the-general-population-a-systematic-review
#11
T H M Moore, N Kapur, K Hawton, A Richards, C Metcalfe, D Gunnell
BACKGROUND: Job loss, debt and financial difficulties are associated with increased risk of mental illness and suicide in the general population. Interventions targeting people in debt or unemployed might help reduce these effects. METHOD: We searched MEDLINE, Embase, The Cochrane Library, Web of Science, and PsycINFO (January 2016) for randomized controlled trials (RCTs) of interventions to reduce the effects of unemployment and debt on mental health in general population samples...
December 15, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27965879/consort-2010-statement-extension-to-randomised-pilot-and-feasibility-trials
#12
EDITORIAL
Sandra M Eldridge, Claire L Chan, Michael J Campbell, Christine M Bond, Sally Hopewell, Lehana Thabane, Gillian A Lancaster
The Consolidated Standards of Reporting Trials (CONSORT) statement is a guideline designed to improve the transparency and quality of the reporting of randomised controlled trials (RCTs). In this article we present an extension to that statement for randomised pilot and feasibility trials conducted in advance of a future definitive RCT. The checklist applies to any randomised study in which a future definitive RCT, or part of it, is conducted on a smaller scale, regardless of its design (eg, cluster, factorial, crossover) or the terms used by authors to describe the study (eg, pilot, feasibility, trial, study)...
2016: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/27965844/methods-and-processes-for-development-of-a-consort-extension-for-reporting-pilot-randomized-controlled-trials
#13
Lehana Thabane, Sally Hopewell, Gillian A Lancaster, Christine M Bond, Claire L Coleman, Michael J Campbell, Sandra M Eldridge
BACKGROUND: Feasibility and pilot studies are essential components of planning or preparing for a larger randomized controlled trial (RCT). They are intended to provide useful information about the feasibility of the main RCT-with the goal of reducing uncertainty and thereby increasing the chance of successfully conducting the main RCT. However, research has shown that there are serious inadequacies in the reporting of pilot and feasibility studies. Reasons for this include a lack of explicit publication policies for pilot and feasibility studies in many journals, unclear definitions of what constitutes a pilot or feasibility RCT/study, and a lack of clarity in the objectives and methodological focus...
2016: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/27956817/a-systematic-review-of-orthopaedic-manual-therapy-randomized-clinical-trials-quality
#14
Sean P Riley, Brian Swanson, Jean-Michel Brismée, Steven F Sawyer
Study Design: Systematic review and meta-analysis. Objectives: To conduct a systematic review and meta-analysis of randomized clinical trials (RCTs) in the orthopaedic manual therapy (OMT) literature from January 2010 to June 2014 in order to determine if the CONSORT checklist and Cochrane Risk of Bias (RoB) assessment tools: (1) are reliable; (2) have improved the reporting and decreased the risk of bias in RCTs in the OMT literature; (3) differ based on journal impact factor (JIF); and (4) scores are associated with each other...
December 2016: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/27955715/biases-in-research-risk-factors-for-non-replicability-in-psychotherapy-and-pharmacotherapy-research
#15
F Leichsenring, A Abbass, M J Hilsenroth, F Leweke, P Luyten, J R Keefe, N Midgley, S Rabung, S Salzer, C Steinert
Replicability of findings is an essential prerequisite of research. For both basic and clinical research, however, low replicability of findings has recently been reported. Replicability may be affected by research biases not sufficiently controlled for by the existing research standards. Several biases such as researcher allegiance or selective reporting are well-known for affecting results. For psychotherapy and pharmacotherapy research, specific additional biases may affect outcome (e.g. therapist allegiance, therapist effects or impairments in treatment implementation)...
December 13, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27938353/the-quality-of-reporting-of-randomized-controlled-trials-of-electroacupuncture-for-stroke
#16
Jing-Jing Wei, Wen-Ting Yang, Su-Bing Yin, Chen Wang, Yan Wang, Guo-Qing Zheng
BACKGROUND: Electroacupuncture (EA), as an extension technique of acupuncture based on traditional acupuncture combined with modern electrotherapy, is commonly used for stroke in clinical treatment and researches. However, there is still a lack of enough evidence to recommend the routine use of EA for stroke. This study is aimed at evaluating the quality of reporting of randomized controlled trials (RCTs) on EA for stroke. METHODS: RCTs on EA for stroke were evaluated by using CONSORT guidelines and STRICTA guidelines...
December 9, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27930564/effects-of-intraoperative-dexmedetomidine-with-intravenous-anesthesia-on-postoperative-emergence-agitation-delirium-in-pediatric-patients-undergoing-tonsillectomy-with-or-without-adenoidectomy-a-consort-prospective-randomized-controlled-clinical-trial
#17
Jun-Li Cao, Yu-Ping Pei, Jing-Qiu Wei, Yue-Ying Zhang
Postoperative emergence agitation/delirium (POED) is a common complication in pediatric surgery patients, which increases the risk of developing postoperative airway obstruction and respiratory depression. This study aims to investigate the safety and efficacy of intraoperative infusion of dexmedetomidine (DEX) and its effects on POED in pediatric patients undergoing tonsillectomy with or without adenoidectomy.Sixty patients scheduled for tonsillectomy with or without adenoidectomy, aged 2 to 8 years, were randomly allocated into 2 groups (n = 30)...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27930531/prospective-randomized-and-controlled-trial-on-ketamine-infusion-during-bilateral-axillo-breast-approach-baba-robotic-or-endoscopic-thyroidectomy-effects-on-postoperative-pain-and-recovery-profiles-a-consort-compliant-article
#18
Dong-Ho Kim, June Young Choi, Byoung-Gook Kim, Jin-Young Hwang, Seong-Joo Park, Ah-Young Oh, Young-Tae Jeon, Jung-Hee Ryu
BACKGROUND: Robotic or endoscopic thyroidectomy using bilateral axillo-breast approach (BABA) is frequently performed for excellent cosmesis. However, postoperative pain is remained as concerns due to the extent tissue dissection and tension during the operation. Ketamine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist that reduces acute postoperative pain. We evaluated the effects of intraoperative ketamine infusion on postoperative pain control and recovery profiles following BABA robotic or endoscopic thyroidectomy...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27930383/effect-of-e-oj-01-on-cardiac-conditioning-in-young-exercising-adults-a-randomized-controlled-trial
#19
Robert N Girandola, Shalini Srivastava
BACKGROUND AND AIM: Cardiac health is a determinant of athletic performance. A body of data suggests that in healthy young adults, an increase in maximal cardiac output leads to an increase in endurance. Terminalia arjuna (TA) has been studied for multiple benefits in cardiovascular health although its effects as a cardioprotective ergogenic aid require further exploration. The current trial was planned to study the effect of the proprietary TA extract (E-OJ-01) on the markers of cardiac conditioning in healthy young adults...
November 29, 2016: American Journal of Therapeutics
https://www.readbyqxmd.com/read/27923384/the-quality-of-reporting-in-cluster-randomised-crossover-trials-proposal-for-reporting-items-and-an-assessment-of-reporting-quality
#20
Sarah J Arnup, Andrew B Forbes, Brennan C Kahan, Katy E Morgan, Joanne E McKenzie
BACKGROUND: The cluster randomised crossover (CRXO) design is gaining popularity in trial settings where individual randomisation or parallel group cluster randomisation is not feasible or practical. Our aim is to stimulate discussion on the content of a reporting guideline for CRXO trials and to assess the reporting quality of published CRXO trials. METHODS: We undertook a systematic review of CRXO trials. Searches of MEDLINE, EMBASE, and CINAHL Plus as well as citation searches of CRXO methodological articles were conducted to December 2014...
December 6, 2016: Trials
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