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https://www.readbyqxmd.com/read/28506565/the-antifungal-activity-of-moroccan-plants-and-the-mechanism-of-action-of-secondary-metabolites-from-plants
#1
REVIEW
F Lagrouh, N Dakka, Y Bakri
This review is based on a comprehensive literature search for existing knowledge about antifungal mechanisms of different secondary metabolites from plants. The secondary metabolites have been grouped into three major groups according to their biosynthetic origin. On another side, this review represents studies on antifungal activity of essential oils and extracts from Moroccan plants, against fungal species involved in human or plant diseases.
May 11, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28502717/preferential-accumulation-of-gold-nanorods-into-human-skin-hair-follicles-effect-of-nanoparticle-surface-chemistry
#2
Nouf N Mahmoud, Alaaldin M Alkilany, Dörthe Dietrich, Uwe Karst, Amal G Al-Bakri, Enam A Khalil
HYPOTHESIS: Gold nanoparticles (GNP) are considered an ideal model to help understanding the nano-skin interface. The surface functionality of gold nanorods (GNR) is expected to influence the uptake of nanoparticles into specific targets of skin such as hair follicles or dermis. Hence, it should be possible to modify the surface chemistry of GNP to achieve more targeted and safe skin therapy. EXPERIMENTS: GNR functionalized with various surface ligands (neutral, anionic, cationic, and hydrophobic) were evaluated for their accumulation into hair follicles of human skin sheets using ex-vivo setup...
May 6, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28497006/under-pressure-intraluminal-filling-pressures-of-postpartum-hemorrhage-tamponade-balloons
#3
Kathleen M Antony, Diana A Racusin, Michael A Belfort, Gary A Dildy
Objective Uterine tamponade by fluid-filled balloons is now an accepted method of controlling postpartum hemorrhage. Available tamponade balloons vary in design and material, which affects the filling attributes and volume at which they rupture. We aimed to characterize the filling capacity and pressure-volume relationship of various tamponade balloons. Study Design Balloons were filled with water ex vivo. Intraluminal pressure was measured incrementally (every 10 mL for the Foley balloons and every 50 mL for all other balloons)...
April 2017: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/28493376/evaluation-of-the-angiotensin-ii-receptor-blocker-azilsartan-medoxomil-in-african-american-patients-with-hypertension
#4
Wallace Johnson, William B White, Domenic Sica, George L Bakris, Michael A Weber, Alison Handley, Alfonso Perez, Charlie Cao, Stuart Kupfer, Elijah B Saunders
The efficacy and safety of azilsartan medoxomil (AZL-M) were evaluated in African-American patients with hypertension in a 6-week, double-blind, randomized, placebo-controlled trial, for which the primary end point was change from baseline in 24-hour mean systolic blood pressure (BP). There were 413 patients, with a mean age of 52 years, 57% women, and baseline 24-hour BP of 146/91 mm Hg. Treatment differences in 24-hour systolic BP between AZL-M 40 mg and placebo (-5.0 mm Hg; 95% confidence interval, -8...
May 11, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28473971/design-and-implementation-of-the-hepatorenal-fibrocystic-disease-core-center-clinical-database-a-centralized-resource-for-characterizing-autosomal-recessive-polycystic-kidney-disease-and-other-hepatorenal-fibrocystic-diseases
#5
Bakri Alzarka, Hiroki Morizono, John W Bollman, Dongkyu Kim, Lisa M Guay-Woodford
Autosomal recessive polycystic kidney disease (ARPKD) and other hepatorenal fibrocystic diseases (HRFD) are relatively rare recessive disorders that constitute an important set of childhood nephropathies. Little is known about fundamental pathogenesis, and advances toward clinical trials will require well-characterized patient cohorts and the development of predictive and prognostic biomarkers. Such studies in rare diseases require greater collaboration than the efforts in common diseases where large patient repositories can be built at a single site...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28473636/acute-declines-in-renal-function-during-intensive-bp-lowering-implications-for-future-esrd-risk
#6
Elaine Ku, George Bakris, Kirsten L Johansen, Feng Lin, Mark J Sarnak, Vito M Campese, Kenneth Jamerson, Jennifer J Gassman, Miroslaw Smogorzewski, Chi-Yuan Hsu
The magnitude of decline in renal function that should be tolerated during intensive BP lowering and its association with risk of ESRD are unclear. To determine whether the acute declines in kidney function in the intensive BP lowering arm of two trials in CKD associated with higher risk of ESRD, we performed a retrospective study of 899 African American Study of Kidney Disease and Hypertension (AASK) and 761 Modification of Diet in Renal Disease (MDRD) Trial participants previously randomized to strict versus usual BP control...
May 4, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28469384/improving-gastric-cancer-outcome-prediction-using-single-time-point-artificial-neural-network-models
#7
Hamid Nilsaz-Dezfouli, Mohd Rizam Abu-Bakar, Jayanthi Arasan, Mohd Bakri Adam, Mohamad Amin Pourhoseingholi
In cancer studies, the prediction of cancer outcome based on a set of prognostic variables has been a long-standing topic of interest. Current statistical methods for survival analysis offer the possibility of modelling cancer survivability but require unrealistic assumptions about the survival time distribution or proportionality of hazard. Therefore, attention must be paid in developing nonlinear models with less restrictive assumptions. Artificial neural network (ANN) models are primarily useful in prediction when nonlinear approaches are required to sift through the plethora of available information...
2017: Cancer Informatics
https://www.readbyqxmd.com/read/28461725/nmr-based-metabolomic-analysis-of-wild-greenhouse-and-in-vitro-regenerated-shoots-of-cymbopogon-schoenanthus-subsp-proximus-with-gc-ms-assessment-of-proximadiol
#8
Asmaa Abdelsalam, Ehab Mahran, Kamal Chowdhury, Arezue Boroujerdi, Ahmed El-Bakry
Cymbopogon schoenanthus subsp. proximus is a wild plant distributed in subtropical and east Africa extending from the north to the southern parts of Egypt. Widely used in folk medicine, it is the source of the diuretic sesquiterpene proximadiol. Nuclear magnetic resonance metabolomic analysis of polar extracts of shoots from wild, greenhouse, somatic embryos, and direct and indirect organogenic in vitro cultures was carried out. Metabolic profiling yielded 39 compounds, of which common metabolites were 15 (38...
April 2017: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/28458378/differences-in-dynamic-diurnal-blood-pressure-variability-between-japanese-and-american-treatment-resistant-hypertensive-populations
#9
Kazuomi Kario, Deepak L Bhatt, Sandeep Brar, George L Bakris
BACKGROUND: Dynamic diurnal changes in 24-h ambulatory systolic blood pressure (SBP) are associated with increased cardiovascular risk. We compared ambulatory BP dynamics in Japanese and American black and white populations with treatment-resistant hypertension.Methods and Results:Both HTN-Japan (n=41) and SYMPLICITY HTN-3 (n=384 white and n=140 black patients) enrolled patients with office SBP ≥160 mmHg and 24-h ambulatory SBP ≥135 mmHg while on ≥3 antihypertensive medications...
April 29, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28416997/comparison-of-intrathecal-versus-intra-articular-dexmedetomidine-as-an-adjuvant-to-bupivacaine-on-postoperative-pain-following-knee-arthroscopy-a-randomized-clinical-trial
#10
Eman A Ismail, Jehan A Sayed, Mohamed H Bakri, Reda Z Mahfouz
BACKGROUND: Postoperative pain is a common, distressing symptom following arthroscopic knee surgery. The aim of this study was to compare the potential analgesic effect of dexmedetomidine after intrathecal versus intra-articular administration following arthroscopic knee surgery. METHODS: Ninety patients undergoing unilateral elective arthroscopic knee surgery were randomly assigned into three groups in a double-blind placebo controlled study. The intrathecal dexmedetomidine group (IT) received an intrathecal block with intrathecal dexmedetomidine, the intra-articular group (IA) received an intrathecal block and intra-articular dexmedetomidine, and the control group received an intrathecal block and intra-articular saline...
April 2017: Korean Journal of Pain
https://www.readbyqxmd.com/read/28403951/successful-use-of-a-bakri-tamponade-balloon-in-the-treatment-of-puerperal-uterine-inversion-during-caesarean-section
#11
A J Vivanti, E Furet, J Nizard
Acute puerperal inversion of the uterus is a rare life-threatening obstetric emergency, especially during caesarean section. We present the case of a 30-year-old patient with acute puerperal inversion of the uterus that occurred during placental removal. After a quick reversion of the uterus, an immediate postpartum haemorrhage (PPH) due to massive uterine atony was observed. This atony impacted the whole uterus, with a very thin uterine myometrium. The use of a Bakri Tamponade Balloon use allowed treating extreme uterine atony, immediately stop haemorrhage, and prevent a possible risk of immediate recurrence...
January 2017: J Gynecol Obstet Hum Reprod
https://www.readbyqxmd.com/read/28397955/unusual-manifestations-and-unusual-mimics-of-adult-onset-still-s-disease
#12
Marwan H Adwan, Faris G Bakri, Ahmad Z Qureshi
[No Abstract Available].
April 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28388938/subtyping-of-blastocystis-sp-isolated-from-symptomatic-and-asymptomatic-individuals-in-makkah-saudi-arabia
#13
Raafat T Mohamed, Mohammed A El-Bali, Anhar A Mohamed, Mona A Abdel-Fatah, Mohamed A El-Malky, Nawras M Mowafy, Dina A Zaghlool, Rowaida A Bakri, Saeed A Al-Harthi
BACKGROUND: Blastocystis is a group of cosmopolitan gastrointestinal parasite of humans and a wide variety of animals. These anaerobic protozoans include more than 17 specific small-subunit ribosomal RNA subtypes, of which nine are found in humans with a variable geographical distribution. Until now, no study has described the Blastocystis subtypes present in Saudi Arabia. METHODS: In total, 1,262 faecal samples were collected from patients with gastrointestinal complaints and asymptomatic individuals visiting two major hospitals...
April 7, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28387186/efficacy-of-10-percent-carbamide-peroxide-as-an-intracoronal-bleaching-agent-in-nonvital-discolored-primary-teeth-an-in-vitro-study
#14
Miram Abd El Magied Shaheen, Mona Abdallah Elkateb, Niveen Samir Bakry, Omar Abd El Sadek El Meligy
PURPOSE: The purpose of this study was to evaluate, in vitro, the efficacy of 10 percent carbamide peroxide used as an intracoronal bleaching agent in blood-stained primary teeth. METHODS: Thirty extracted primary canines were stained using rabbit blood and randomly divided into two groups of 15 teeth each. Stained teeth in the test group were bleached intracoronally using 10 percent carbamide peroxide for 21 days. The bleaching agent was replaced at days seven and 14...
January 15, 2017: Journal of Dentistry for Children
https://www.readbyqxmd.com/read/28372979/the-use-of-flow-cytometry-to-examine-calcium-signalling-by-trpv1-in-mixed-cell-populations
#15
Bakri M Assas, Wesam H Abdulaal, Majed H Wakid, Haytham A Zakai, J Miyan, J L Pennock
Flow cytometric analysis of calcium mobilisation has been in use for many years in the study of specific receptor engagement or isolated cell:cell communication. However, calcium mobilisation/signaling is key to many cell functions including apoptosis, mobility and immune responses. Here we combine multiplex surface staining of whole spleen with Indo-1 AM to visualise calcium mobilisation and examine calcium signaling in a mixed immune cell culture over time. We demonstrate responses to a TRPV1 agonist in distinct cell subtypes without the need for cell separation...
March 31, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28371626/correlation-between-numbers-of-cells-in-human-dental-pulp-and-age-implications-for-age-estimation
#16
Mohammad Zakir Hossain, Sulinda Daud, Phrabhakaran Nambiar, Fathilah Abdul Razak, Norintan Ab-Murat, Roslan Saub, Marina M Bakri
OBJECTIVE: The aim of this study was to investigate correlations between dental pulp cell count of odontoblasts, subodontoblasts and fibroblasts and age, within different age groups. Formulation of regression equations using the dental pulp cell count for predicting age was attempted. DESIGN: Eighty-one extracted teeth were grouped into two age groups (6-25 years, 26-80 years). The teeth were demineralized and histological sections were prepared for cell count. Regression equations were generated from regression analysis of cell count and tested for age estimation...
March 24, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28369902/oral-health-behavior-and-factors-associated-with-poor-oral-status-in-qatar-results-from-a-national-health-survey
#17
Sohaila Cheema, Patrick Maisonneuve, Mohamed Hamad Al-Thani, Al Anoud Mohammed Al-Thani, Amit Abraham, Ghanim Ali Al-Mannai, Abdulla Asad Al-Emadi, Walaa Fattah Al-Chetachi, Badria Ali Almalki, Shams Eldin Ali Hassan Khalifa, Ahmad Omar Haj Bakri, Albert Lowenfels, Ravinder Mamtani
OBJECTIVES: Oral health is a crucial determinant of quality of life. We aimed to determine oral health condition and factors associated with poor oral status in the adult national population of Qatar. METHODS: We used data from the World Health Organization supported STEPS (STEPwise approach to Surveillance) Survey conducted by the Supreme Council of Health, Qatar in 2012. A total of 2,496 Qataris (1,053 men, 1,443 women) answered the national survey. The Rao-Scott Chi-Square test was used to analyze oral health characteristics and multinomial logistic regression to assess risk factors...
March 28, 2017: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/28345643/thermal-resistance-variations-of-fly-ash-geopolymers-foaming-responses
#18
Heah Cheng-Yong, Liew Yun-Ming, Mohd Mustafa Al Bakri Abdullah, Kamarudin Hussin
This paper presents a comparative study of the characteristic of unfoamed and foamed geopolymers after exposure to elevated temperatures (200-800 °C). Unfoamed geopolymers were produced with Class F fly ash and sodium hydroxide and liquid sodium silicate. Porous geopolymers were prepared by foaming with hydrogen peroxide. Unfoamed geopolymers possessed excellent strength of 44.2 MPa and degraded 34% to 15 MPa in foamed geopolymers. The strength of unfoamed geopolymers decreased to 5 MPa with increasing temperature up to 800 °C...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28342389/pilot-randomised-controlled-trial-comparing-the-risk-of-neonatal-respiratory-distress-in-elective-caesarean-section-at-38-weeks-gestation-following-a-course-of-corticosteroids-versus-caesarean-at-39-weeks
#19
Nicolas Sananès, Antoine Koch, Benoît Escande, Germain Aissi, Gabrielle Fritz, Emmanuel Roth, Michèle Weil, Ahmad Bakri, Chantal Bolender, Nicolas Meyer, Christophe Vayssiere, Adrien Gaudineau, Israël Nisand, Romain Favre, Pierre Kuhn, Bruno Langer
INTRODUCTION: The objective of this study was to compare neonatal respiratory morbidity and rate of emergency caesarean section between elective caesarean sections at 38 gestational weeks following a course of corticosteroids and planned caesarean sections at 39 gestational weeks. MATERIAL AND METHODS: This was a multicentre randomised controlled trial. The study was conducted between 2007 and 2013 in level 2 and 3 maternity units in France. A total of 208 women with an indication for elective caesarean section were enrolled and 200 analysed in per-protocol analysis...
May 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28340669/maximizing-the-utility-of-the-pedicled-anterolateral-thigh-flap-for-locoregional-reconstruction-technical-pearls-and-pitfalls
#20
REVIEW
Aparna Vijayasekaran, Waleed Gibreel, Brian T Carlsen, Steven L Moran, Michel Saint-Cyr, Karim Bakri, Basel Sharaf
The pedicled anterolateral thigh (PALT) flap is an underutilized flap for locoregional reconstruction largely because methods to maximize its reach are neither universally implemented nor fully understood. In addition, most of the available literature has focused on the utility of the free anterolateral thigh flap with less emphasis on the PALT flap. Moreover, flap design concepts to maximize its utility and reach and optimize outcomes have not been comprehensively described. In an effort to address this knowledge gap, the authors sought to review their institution's experience with the PALT flap for locoregional reconstruction...
April 2017: Clinics in Plastic Surgery
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