keyword
MENU ▼
Read by QxMD icon Read
search

mayo

keyword
https://www.readbyqxmd.com/read/28726808/prevalence-of-germ-line-mutations-in-cancer-genes-among-pancreatic-cancer-patients-with-a-positive-family-history
#1
Kari G Chaffee, Ann L Oberg, Robert R McWilliams, Neil Majithia, Brian A Allen, John Kidd, Nanda Singh, Anne-Renee Hartman, Richard J Wenstrup, Gloria M Petersen
PurposePanel-based genetic testing has identified increasing numbers of patients with pancreatic ductal adenocarcinoma (PDAC) who carry germ-line mutations. However, small sample sizes or number of genes evaluated limit prevalence estimates of these mutations. We estimated prevalence of mutations in PDAC patients with positive family history.MethodsWe sequenced 25 cancer susceptibility genes in lymphocyte DNA from 302 PDAC patients in the Mayo Clinic Biospecimen Resource for Pancreatic Research Registry. Kindreds containing at least two first-degree relatives with PDAC met criteria for familial pancreatic cancer (FPC), while the remaining were familial, but not FPC...
July 20, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28725500/volar-plate-fixation-in-patients-older-than-70-years-with-ao-type-c-distal-radial-fractures-clinical-and-radiologic-outcomes
#2
Nicolas S Piuzzi, Ezequiel E Zaidenberg, Matias Pereira Duarte, Jorge G Boretto, Agustin Donndorff, Gerardo Gallucci, Pablo De Carli
Introduction  Treatment of unstable distal radial fractures (DRFs) in elderly patients is controversial, and considering the increasing life expectancy, their appropriate treatment is of growing importance. Our aim was to analyze the clinical and radiologic outcomes in the elderly patients with AO type C DRF treated with volar locking plate (VLP). Materials and Methods  Between 2007 and 2011, 572 DRFs were operated on in our hospital with open reduction and internal fixation with VLP. Of these, only 64 patients (66 DRFs) met the selection criteria (AO type C DRF, age > 70 years, minimum 12-month follow-up)...
August 2017: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/28725226/jnk-pathway-associated-phosphatase-dusp22-suppresses-cd4-t-cell-activation-and-th1-th17-cell-differentiation-and-negatively-correlates-with-clinical-activity-in-inflammatory-bowel-disease
#3
Rui Zhou, Ying Chang, Jing Liu, Min Chen, Hongling Wang, Meifang Huang, Shi Liu, Xiaobing Wang, Qiu Zhao
This study aimed to investigate the role of JNK pathway-associated phosphatase (JKAP) in inflammatory bowel disease (IBD). JKAP expression was analyzed in the intestinal mucosa of 81 IBD patients and 25 healthy controls (HCs) by qPCR and immunoblotting. The correlations of JKAP with clinical activity and inflammatory cytokines were performed. JKAP expression before and after infliximab treatment was also measured. CD4(+) T cells were isolated from peripheral blood in active IBD patient and HCs and transduced with lentivirus-encoding JKAP (LV-JKAP), anti-JKAP (LV-anti-JKAP), or empty vector (LV-scramble), and JKAP functions on IBD CD4(+) T cells were subsequently investigated...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28725184/sevoflurane-induces-coherent-slow-delta-oscillations-in-rats
#4
Jennifer A Guidera, Norman E Taylor, Justin T Lee, Ksenia Y Vlasov, JunZhu Pei, Emily P Stephen, J Patrick Mayo, Emery N Brown, Ken Solt
Although general anesthetics are routinely administered to surgical patients to induce loss of consciousness, the mechanisms underlying anesthetic-induced unconsciousness are not fully understood. In rats, we characterized changes in the extradural EEG and intracranial local field potentials (LFPs) within the prefrontal cortex (PFC), parietal cortex (PC), and central thalamus (CT) in response to progressively higher doses of the inhaled anesthetic sevoflurane. During induction with a low dose of sevoflurane, beta/low gamma (12-40 Hz) power increased in the frontal EEG and PFC, PC and CT LFPs, and PFC-CT and PFC-PFC LFP beta/low gamma coherence increased...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28723856/fecal-matrix-metalloprotease-9-and-lipocalin-2-as-biomarkers-in-detecting-endoscopic-activity-in-patients-with-inflammatory-bowel-diseases
#5
Anthony Buisson, Emilie Vazeille, Régine Minet-Quinard, Marion Goutte, Damien Bouvier, Félix Goutorbe, Bruno Pereira, Nicolas Barnich, Gilles Bommelaer
BACKGROUND: Fecal biomarkers are emerging tools in the assessment of mucosal healing in inflammatory bowel diseases (IBD). GOALS: We aimed to evaluate the accuracy of fecal matrix metalloprotease-9 (MMP-9) and fecal lipocalin-2 (LCN-2) compared with calprotectin in detecting endoscopic activity in IBD STUDY:: Overall, 86 IBD adults underwent colonoscopy consecutively and prospectively, with Crohn's disease Endoscopic Index of Severity (CDEIS) in Crohn's disease (CD) patients or Mayo endoscopic subscore calculation for ulcerative colitis (UC) patients, and stool collection...
July 18, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28723492/validation-of-gene-expression-signatures-to-identify-low-risk-clear-cell-renal-cell-carcinoma-patients-at-higher-risk-for-disease-related-death
#6
Mansi Parasramka, Daniel J Serie, Yan W Asmann, Jeanette E Eckel-Passow, Erik P Castle, Melissa L Stanton, Brad C Leibovich, Robert Houston Thompson, E Aubrey Thompson, Alexander S Parker, Thai H Ho, Richard W Joseph
BACKGROUND: Approximately 5-10% of patients with "low-risk" clear cell renal cell carcinoma (ccRCC), as stratified by externally validated clinicopathologic prognostic algorithms, eventually have disease relapse and die. Improving prognostic algorithms for these low-risk patients could help to provide improved individualized surveillance recommendations. OBJECTIVE: To identify genes that are differentially expressed in patients with low-risk ccRCC who did and did not die of their disease...
December 15, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28721978/noninvasive-biomarkers-as-surrogate-predictors-of-clinical-and-endoscopic-remission-after-infliximab-induction-in-patients-with-refractory-ulcerative-colitis
#7
Elham A Hassan, Haidi K Ramadan, Ali A Ismael, Khaled F Mohamed, Madiha M El-Attar, Ihab Alhelali
BACKGROUND/AIMS: Treatment of refractory ulcerative colitis (UC) is a clinical challenge, and after biological therapy, monitoring clinical and endoscopic responses is fundamental. We aimed to investigate and compare the predictive power of different noninvasive parameters for clinical remission and mucosal healing after infliximab induction therapy in refractory UC patients. PATIENTS AND METHODS: Serum and fecal biomarkers, including hemoglobin, white blood cells, erythrocyte sedimentation rate, C-reactive protein (CRP), and fecal calprotectin (FC), and colonoscopy were assessed in 44 patients with refractory UC before and after (week 12) infliximab induction...
July 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28719473/delayed-patch-test-reading-after-5-days-an-update-from-the-mayo-clinic-contact-dermatitis-group
#8
Hafsa M Chaudhry, Lisa A Drage, Rokea A El-Azhary, Matthew R Hall, Jill M Killian, Amy V Prakash, James A Yiannias, Mark D P Davis
BACKGROUND: Patch-test readings after day 5 have previously been used to identify delayed reactions to metals and topical antibiotics. OBJECTIVE: The aims of this study were to identify allergens for which late readings (beyond day 5) would be most valuable and to compare our results with our previous study on delayed patch-test readings. METHODS: This was a retrospective study of 298 patients who underwent metal and corticosteroid series patch testing from January 1, 2007, through December 31, 2013...
July 2017: Dermatitis
https://www.readbyqxmd.com/read/28716436/frontal-fibrosing-alopecia-among-men-a%C3%A2-clinicopathologic-study-of-7-cases
#9
Stanislav N Tolkachjov, Hafsa M Chaudhry, Michael J Camilleri, Rochelle R Torgerson
BACKGROUND: Frontal fibrosing alopecia (FFA) is a lichen planopilaris-variant scarring alopecia that has rarely been described in men. OBJECTIVE: To characterize the clinicopathologic findings of FFA in men by studying a series of 7 male patients. METHODS: We conducted a retrospective review of all cases of male patients with FFA at the Mayo Clinic from 1992 to 2016. RESULTS: Seven male patients with FFA were identified...
July 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28716055/temporal-and-geographical-external-validation-study-and-extension-of-the-mayo-clinic-prediction-model-to-predict-egfr-in-the-younger-population-of-swiss-adpkd-patients
#10
Laura Girardat-Rotar, Julia Braun, Milo A Puhan, Alison G Abraham, Andreas L Serra
BACKGROUND: Prediction models in autosomal dominant polycystic kidney disease (ADPKD) are useful in clinical settings to identify patients with greater risk of a rapid disease progression in whom a treatment may have more benefits than harms. Mayo Clinic investigators developed a risk prediction tool for ADPKD patients using a single kidney value. Our aim was to perform an independent geographical and temporal external validation as well as evaluate the potential for improving the predictive performance by including additional information on total kidney volume...
July 17, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28715088/clinical-limitations-of-the-international-federation-of-gynecology-and-obstetrics-figo-staging-of-uterine-fibroids
#11
Shannon K Laughlin-Tommaso, Gina K Hesley, Matthew R Hopkins, Kathleen R Brandt, Yunxiao Zhu, Elizabeth A Stewart
OBJECTIVE: To determine the reproducibility of classifying uterine fibroid using the 2011 International Federation of Gynecology and Obstetrics (FIGO) staging system. METHODS: The present retrospective cohort study included patients presenting for the treatment of symptomatic uterine fibroids at the Gynecology Fibroid Clinic at Mayo Clinic, Rochester, USA, between April 1, 2013 and April 1, 2014. Magnetic resonance imaging of fibroid uteri was performed and the images were independently reviewed by two academic gynecologists and two radiologists specializing in fibroid care...
July 17, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28714816/opportunities-and-efficiencies-in-building-a-new-service-desk-model
#12
Alexa Mayo, Everly Brown, Ryan Harris
In July 2015, the Health Sciences and Human Services Library (HS/HSL) at the University of Maryland, Baltimore (UMB), merged its reference and circulation services, creating the Information Services Department and Information Services Desk. Designing the Information Services Desk with a team approach allowed for the re-examination of the HS/HSL's service model from the ground up. With the creation of a single service point, the HS/HSL was able to create efficiencies, improve the user experience by eliminating handoffs, create a collaborative team environment, and engage information services staff in a variety of new projects...
July 2017: Medical Reference Services Quarterly
https://www.readbyqxmd.com/read/28713336/development-and-use-of-a-real-time-quantitative-pcr-method-for-detecting-and-quantifying-equol-producing-bacteria-in-human-faecal-samples-and-slurry-cultures
#13
Lucía Vázquez, Lucía Guadamuro, Froilán Giganto, Baltasar Mayo, Ana B Flórez
This work introduces a novel real-time quantitative PCR (qPCR) protocol for detecting and quantifying equol-producing bacteria. To this end, two sets of primers targeting the dihydrodaidzein reductase (ddr) and tetrahydrodaidzein reductase (tdr) genes, which are involved in the synthesis of equol, were designed. The primers showed high specificity and sensitivity when used to examine DNA from control bacteria, such as Slackia isoflavoniconvertens, Slackia equolifaciens, Asaccharobacter celatus, Adlercreutzia equolifaciens, and Enterorhabdus mucosicola...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28713062/a-prospective-study-on-second-generation-colon-capsule-endoscopy-to-detect-mucosal-lesions-and-disease-activity-in-ulcerative-colitis-with-video
#14
Hai Yun Shi, Francis Kl Chan, Akira Higashimori, Moe Kyaw, Jessica Yl Ching, Heyson Ch Chan, Joey Ch Chan, Anthony Wh Chan, Kelvin Ly Lam, Raymond Sy Tang, Justin Cy Wu, Joseph Jy Sung, Siew C Ng
BACKGROUND & AIMS: Mucosal healing is the goal for ulcerative colitis (UC) therapy, but needs to be confirmed under colonoscopy. Colon capsule endoscopy (CCE) is a noninvasive technique for colon investigation. Our study investigated the accuracy of the second-generation CCE (CCE-2) to assess mucosal lesions and disease activity in UC. METHODS: In this prospective study, CCE-2 and conventional colonoscopy were performed on the same day. CCE-2 reviewers and colonoscopists used Mayo endoscopic subscore (MES) and Ulcerative Colitis Endoscopic Index of Severity (UCEIS) to assess disease activity, and were blinded to each other's findings...
July 13, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28712954/social-media-platforms-and-heart-failure
#15
R Jay Widmer, Makala K Arce, Lee A Aase, Farris K Timimi
With the pervasive use of the internet and social media, the potential applicability toward patients with heart failure (HF) remains understudied. Here, we outline the general use of social media and some early work utilizing social media as well as data from our own Mayo Clinic Center for Social Media experience. Both enterprise-wide social media data as well as those specific to HF-related pages and posts appear to support the preferential use of Facebook and YouTube for potential benefit in patients with HF...
July 13, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28712184/service-quality-of-diagnostic-fine-needle-aspiration-cytology-in-a-tertiary-care-hospital-of-lahore-process-measure-as-patient-s-perspective
#16
Zainab Rizvi, Rabia Arshed Usmani, Amna Rizvi, Salim Wazir, Taskeen Zahra, Hafza Rasool
BACKGROUND: Quality of any service is the most important aspect for the manufacturer as well as the consumer. The primary objective of any nation's health system is to provide supreme quality health care services to its patients. The objective of this study was to assess the quality of diagnostic fine needle aspiration cytology service in a tertiary care hospital. As Patient's perspectives provide valuable information on quality of process, therefore, patient's perception in terms of satisfaction with the service was measured...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28712174/arthrocentesis-for-temporomandibular-joint-pain-dysfunction-syndrome
#17
Shahid Rauf Jamot, Zafar Ali Khan, Tahir Ullah Khan, Riaz Ahmad Waraich, Muhammad Farooq
BACKGROUND: Temporomandibular joint (TMJ) dysfunction is painful condition of facial musculoskeletal system. Arthrocentesis is less invasive treatment of TMJ dysfunctions. It has been used to treat variety of TMJ disorders. The objective of this study was to determine the success of arthrocentesis in TMJPDS patients where conservative treatment had failed. METHODS: This descriptive case study of 45 patients was completed in 6 months at Outpatient Department of Oral and Maxillofacial Surgery, Mayo hospital Lahore...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28711600/double-plating-as-treatment-for-supracondylar-humeral-fractures
#18
J Salvador, P Castillón, I Fuentes, M Bernaus, F Anglès
INTRODUCTION AND OBJECTIVES: Supracondylar humeral fractures represent only about 0.5-1% of all fractures in adults. The objective of this study is to evaluate functional outcome and quality of life in patients treated with open reduction and internal fixation using double plates. MATERIAL AND METHODS: We designed a retrospective descriptive study including 27 supracondylar humeral fractures treated with open reduction and internal fixation using two anatomic plates from January 2005 to September 2012...
July 12, 2017: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/28710861/differential-protein-modulation-by-ketoprofen-and-ibuprofen-underlines-different-cellular-response-by-gastric-epithelium
#19
L Brandolini, M d'Angelo, A Antonosante, S Villa, L Cristiano, V Castelli, E Benedetti, M Catanesi, A Aramini, A Luini, S Parashuraman, E Mayo, A Giordano, A Cimini, M Allegretti
Ketoprofen L-lysine salt (KLS), is widely used due to its analgesic efficacy and tolerability, and L-lysine was reported to increase the solubility and the gastric tolerance of ketoprofen. In a recent report, L-lysine salification has been shown to exert a gastroprotective effect due to its specific ability to counteract the NSAIDs-induced oxidative stress and up-regulate gastroprotective proteins. In order to derive further insights into the safety and efficacy profile of KLS, in this study we additionally compared the effect of lysine and arginine, another amino acid counterion commonly used for NSAIDs salification, in control and in ethanol challenged human gastric mucosa model...
July 15, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28706093/does-neutrophil-to-lymphocyte-ratio-predict-1-year-mortality-in-patients-with-primary-biliary-cholangitis-results-from-a-retrospective-study-with-validation-cohort
#20
Lin Lin, Meiyu Piao, Xihui Jiang, Houning Lv, Ningning Zhao, Fang Yang, Chao Sun
OBJECTIVES: Neutrophil-to-lymphocyte ratio (NLR) has been used to predict prognosis in various liver diseases, but its role in primary biliary cholangitis (PBC) is not clarified. We aimed to investigate the prognostic usefulness of NLR for 1-year mortality in PBC. METHODS: The study recruited a retrospective cohort with 88 patients with PBC and a prospective validation cohort with 63 participants who were followed-up for 1 year. NLR and other laboratory measurements were analysed by multivariate regression model for identifying independent factors for early mortality...
July 12, 2017: BMJ Open
keyword
keyword
53265
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"