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Dengue virus

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https://www.readbyqxmd.com/read/29238544/population-genomics-of-the-asian-tiger-mosquito-aedes-albopictus-insights-into-the-recent-worldwide-invasion
#1
Panayiota Kotsakiozi, Joshua B Richardson, Verena Pichler, Guido Favia, Ademir J Martins, Sandra Urbanelli, Peter A Armbruster, Adalgisa Caccone
Aedes albopictus, the "Asian tiger mosquito," is an aggressive biting mosquito native to Asia that has colonized all continents except Antarctica during the last ~30-40 years. The species is of great public health concern as it can transmit at least 26 arboviruses, including dengue, chikungunya, and Zika viruses. In this study, using double-digest Restriction site-Associated DNA (ddRAD) sequencing, we developed a panel of ~58,000 single nucleotide polymorphisms (SNPs) based on 20 worldwide Ae. albopictus populations representing both the invasive and the native range...
December 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29234310/modulation-of-lipid-droplet-metabolism-a-potential-target-for-therapeutic-intervention-in-flaviviridae-infections
#2
REVIEW
Jingshu Zhang, Yun Lan, Sumana Sanyal
Lipid droplets (LDs) are endoplasmic reticulum (ER)-related dynamic organelles that store and regulate fatty acids and neutral lipids. They play a central role in cellular energy storage, lipid metabolism and cellular homeostasis. It has become evident that viruses have co-evolved in order to exploit host lipid metabolic pathways. This is especially characteristic of the Flaviviridae family, including hepatitis C virus (HCV) and several flaviviruses. Devoid of an appropriate lipid biosynthetic machinery of their own, these single-strand positive-sense RNA viruses can induce dramatic changes in host metabolic pathways to establish a favorable environment for viral multiplication and acquire essential components to facilitate their assembly and traffic...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29233775/an-exploration-of-the-role-of-asymptomatic-infections-in-the-epidemiology-of-dengue-viruses-through-susceptible-asymptomatic-infected-and-recovered-sair-models
#3
Martin Grunnill
It is estimated that 20-97% of all dengue infections could be asymptomatic. I used SIR models to investigate the epidemiological role of such infections, by adding an asymptomatic class (SAIR models). Upon infection in one of the models, a human becomes either symptomatic or asymptomatic. In the other, a human becomes asymptomatic and may progress to being symptomatic. The robustness of results from these models is examined by incorporating the mosquito-vector into one of the models, followed by simulating epidemic dynamics stochastically...
December 9, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29233744/a-flavonoid-compound-library-screen-revealed-potent-antiviral-activity-of-plant-derived-flavonoids-on-human-enterovirus-a71-replication
#4
Nyo Min, Leong Pok Thim, Regina Ching Hua Lee, Jeffery Seng Eng Khuan, Justin Jang Hann Chu
Hand Foot Mouth Disease (HFMD), resulting from human enterovirus A71 (HEVA71) infection can cause severe neurological complications leading to fatality in young children. Currently, there is no approved antiviral for therapeutic treatment against HEVA71 infection. In this study, a 500-compound flavonoid library was screened to identify potential inhibitors of HEVA71 using high-throughput immunofluorescence-based phenotypic screening method. Two lead flavonoid compounds, ST077124 and ST024734 at the non-cytotoxic concentration of 50 μM were found to be effective antivirals that inhibited replication of HEVA71, reducing infectious viral titers by 3...
December 9, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29232534/detection-of-dengue-virus-in-bat-flies-diptera-streblidae-of-common-vampire-bats-desmodus-rotundus-in-progreso-hidalgo-mexico
#5
Judith Abundes-Gallegos, Monica Salas-Rojas, Guillermo Galvez-Romero, Leonardo Perea-Martínez, Cirani Y Obregón-Morales, Juan B Morales-Malacara, Bruno B Chomel, Matthew J Stuckey, Hayde Moreno-Sandoval, Anahi García-Baltazar, Benjamin Nogueda-Torres, Gerardo Zuñiga, Alvaro Aguilar-Setién
Blood-feeding arthropods play a major role in the transmission of several flaviviruses, which represent an important problem for human health. Currently, dengue is one of the most important arboviral emerging diseases worldwide. Furthermore, some previous studies have reported the presence of viral nucleic acids and antibodies against dengue virus (DENV) in wild animals. Our knowledge of the role played by wildlife reservoirs in the sylvatic transmission and maintenance of DENV remains limited. Our objective was to screen blood-feeding ectoparasites (bat flies) and their common vampire bat (Desmodus rotundus) hosts, for flaviviruses in Hidalgo, Mexico...
December 12, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29232453/detection-of-zika-virus-in-aedes-mosquitoes-from-mexico
#6
Herón Huerta, Jesús Felipe González-Roldán, Gustavo Sánchez-Tejeda, Fabián Correa-Morales, Francisco Eduardo Romero-Contreras, Raúl Cárdenas-Flores, Mónica Liliana Rangel-Martínez, Juan Manuel Mata-Rivera, José de Jesús Siller-Martínez, Gonzalo M Vazquez-Prokopec, Pablo Manrique-Saide, Felipe Dzul-Manzanilla, Mauricio Vázquez-Pichardo, Claudia Rosales-Jiménez, María de la Luz Torres-Rodríguez, Alma Núñez-León, Belem Torres-Longoria, Irma López-Martínez, Cuitláhuac Ruíz-Matus, Pablo Antonio Kuri-Morales, José Alberto Díaz-Quiñónez
Background: We report on the results of an entomovirological surveillance system of Aedes populations performed by the Ministry of Health of the central state of San Luis Potosí, Mexico. Methods: Indoor adult Aedes aegypti and Aedes albopictus pools collected at San Martín, Tamazunchale, Ciudad Valles, Metlapa, Ebano, Tamuin and Axtla during the dry season of 2016 were examined for the presence of dengue (DENV), chikungunya (CHIKV) and Zika (ZIKV) viruses using real-time PCR...
July 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29228413/estimating-vector-borne-viral-infections-in-the-urban-setting-of-the-2020-tokyo-olympics-japan-using-mathematical-modeling
#7
Hiroyuki Furuya
The first domestic outbreak of dengue fever in Japan since 1945 was reported in Tokyo in 2014. Meanwhile, daily mean summer temperatures are expected to continue to rise world-wide. Such conditions are expected to increase the risk of an arbovirus outbreak at the 2020 Tokyo Olympic Games. To address this possibility, the present study compared estimates of the risk of infection by dengue, chikungunya, and Zika viruses in urban areas. To compare the risk of infection by arboviruses transmitted by Ae. albopictus mosquitoes, the reproduction number for each of three arboviruses was estimated under the environmental conditions associated with the 2014 dengue outbreak in Tokyo, and additionally under conditions assuming a daily mean temperature elevation of 2° C...
December 20, 2017: Tokai Journal of Experimental and Clinical Medicine
https://www.readbyqxmd.com/read/29228197/efficacy-of-13-commercial-household-aerosol-insecticides-against-aedes-aegypti-diptera-culicidae-from-morelos-mexico
#8
Pablo A Kuri-Morales, Fabián Correa-Morales, Cassandra González-Acosta, Miguel Moreno-Garcia, Eduardo Dávalos-Becerril, José Ismael Benitez-Alva, Jorge Peralta-Rodriguez, Victor Salazar-Bueyes, Jesús F González-Roldán
In Mexico, Aedes aegypti (L.) (Diptera: Culicidae) is the primary vector of Dengue, Zika, and Chikungunya viruses. Control programs include community participation using personal protection such as household aerosol insecticides. In both, urban or rural areas, the use of aerosol insecticides is a common practice to avoiding mosquito biting. Thus, information on the efficacy of commercial products must be available. This study reports the efficacy of 13 household aerosol insecticides against Ae. aegypti from an endemic dengue area in Mexico...
December 8, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29226326/retreg1-fam134b-a-new-player-in-human-diseases-15-years-after-the-discovery-in-cancer
#9
REVIEW
Farhadul Islam, Vinod Gopalan, Alfred King-Yin Lam
FAM134B (family with sequence similarity 134, member B) / RETREG1 and its functional roles are relatively new in human diseases. This review aimed to summarize various functions of FAM134B since our first discovery of the gene in 2001. The protein encoded by FAM134B is a reticulophagy receptor that regulates turnover of the endoplasmic reticulum (ER) by selective phagocytosis. Absence or non-functional expression of FAM134B protein impairs ER-turnover and thereby is involved in the pathogenesis of some human diseases...
December 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29225757/dengue-fever-in-a-south-asian-metropolis-a-report-on-219-cases
#10
Shiv Sekhar Chatterjee, Ankush Sharma, Shilpee Choudhury, Sushil Kumar Chumber, Ras Bage, Nittin Parkhe, Uma Khanduri
Background and Objectives: Yearly epidemics of Dengue fever occur post-monsoon in India's capital, Delhi. A prospective observational study was conducted during the outbreak months to understand the epidemiology and outcome of this infection and its economic impact. Materials and Methods: Febrile hospitalized (n=219) patients with dengue fever diagnosed by a combination of MAC-ELISA, GAC-ELISA and NS1Antigen-ELISA were enrolled. Epidemiologic (including economic) parameters, clinical, radiological and laboratory manifestations were noted and patients followed up over the period of hospital stay...
June 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29225429/in-silico-validation-of-d7-salivary-protein-derived-b-and-t-cell-epitopes-of-aedes-aegypti-as-potential-vaccine-to-prevent-transmission-of-flaviviruses-and-togaviruses-to-humans
#11
Sathish Sankar, Mageshbabu Ramamurthy, Balaji Nandagopal, Gopalan Sridharan
Mosquito (Aedes aegyptii) salivary proteins play a crucial role in facilitating viral transmission from vector-to-host due to their role in facilitating the "blood meal" of the vector. Three main proteins, D7, aegyptin and Sialokinin play a role in this process. Using in-silico programs, we identified B- and T-cell epitopes in the mosquito salivary proteins D7 long and short form. T-cell epitopes with high affinity to the most prevalent HLA MHC class-I supertypes among different population groups was chosen...
2017: Bioinformation
https://www.readbyqxmd.com/read/29221616/dengue-fever-report-from-the-task-force-on-tropical-diseases-by-the-world-federation-of-societies-of-intensive-and-critical-care-medicine
#12
REVIEW
Pravin Amin, Özlem Acicbe, Jorge Hidalgo, Juan Ignacio Silesky Jiménez, Tim Baker, Guy A Richards
Dengue is an arbovirus affecting humans and spread by mosquitoes. Severe dengue follows a secondary infection with a different virus serotype. The problem is truly global as it is endemic in over 100 countries. Severe dengue can be a life-threatening because of increased vascular permeability, resulting in leakage of fluid from the intravascular compartment to the extravascular space. When major bleeding does occur, it is almost invariably combined with profound shock since this, in combination with thrombocytopenia, hypoxia, and acidosis, can lead to multiple organ failure and disseminated intravascular coagulation...
November 5, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29221523/estimating-effects-of-temperature-on-dengue-transmission-in-colombian-cities
#13
Víctor Hugo Peña-García, Omar Triana-Chávez, Sair Arboleda-Sánchez
BACKGROUND: Dengue fever is a viral disease that affects tropical and subtropical regions of the world. It is well known that processes related to virus transmission by mosquitoes are highly influenced by weather. Temperature has been described as one of the climatic variables that largely governs the development and survival of mosquito eggs as well as the survival of all insect stages. Previously, we noted that high temperatures in the Colombian city of Riohacha negatively affect the establishment of dengue virus (DENV) infection in mosquitoes; in Bello and Villavicencio cities, which have lower average temperatures, DENV infection rates in mosquitoes are positively associated with a gradual increase in temperature...
May 2017: Annals of Global Health
https://www.readbyqxmd.com/read/29220773/climate-change-and-dengue-fever-transmission-in-china-evidences-and-challenges
#14
REVIEW
Chenlu Li, Yongmei Lu, Jianing Liu, Xiaoxu Wu
Dengue Fever (DF) has become one of the most serious infectious diseases in China. Dengue virus and its vector (Aedes mosquito) are known to be sensitive to climate condition. Climate impacts DF through affecting three essential bioecological aspects: DF virus, vector (mosquito) and DF transmission environment. Weather-based DF model, mosquito model and climate model are the three pillars to help the prediction of DF distribution. Through a systematic review of literature between 1980 and 2017, this paper summarizes empirical evidences in China on the impact of climate change on DF; it further reviews the related DF incidence models and their findings on how changes in weather factors may impact DF occurrences in China...
December 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29217264/the-immune-strategies-of-mosquito-aedes-aegypti-against-microbial-infection
#15
Yan-Hong Wang, Meng-Meng Chang, Xue-Li Wang, Ai-Hua Zheng, Zhen Zou
Yellow fever mosquito Aedes aegypti transmits many devastating arthropod-borne viruses (arboviruses), such as dengue virus, yellow fever virus, Chikungunya virus, and Zika virus, which cause great concern to human health. Mosquito control is an effective method to block the spread of infectious diseases. Ae. aegypti uses its innate immune system to fight against arboviruses, parasites, and fungi. In this review, we briefly summarize the recent findings in the immune response of Ae. aegypti against arboviral and entomopathogenic infections...
December 4, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29216924/dengue-hemorrhagic-fever-complicated-with-acute-liver-failure-a-case-report
#16
Chamara Dalugama, Indika Bandara Gawarammana
BACKGROUND: Dengue is a common arboviral infection with a clinically diverse spectrum of presentations. Although hepatic dysfunction is commonly identified in patients will dengue illness, acute liver failure is rare. The etiopathogenesis of hepatic dysfunction is multifactorial and related to direct viral invasion of hepatocytes, immunological factors and hypoxia particularly in cases of shock in dengue hemorrhagic fever. Ideal management of dengue-related hepatic dysfunction and acute liver failure is still debated...
December 8, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29216466/the-spatiotemporal-transmission-of-dengue-and-its-driving-mechanism-a-case-study-on-the-2014-dengue-outbreak-in-guangdong-china
#17
Guanghu Zhu, Jianpeng Xiao, Bing Zhang, Tao Liu, Hualiang Lin, Xing Li, Tie Song, Yonghui Zhang, Wenjun Ma, Yuantao Hao
Dengue transmission is a complex spatiotemporal process with hidden interactions between hosts, vectors, and viruses as well as environment. This study aims to identify the transmission patterns and the driving mechanism that contributed to the dengue epidemics occurred in Guangdong Province of China in 2014. Based on the city-specific epidemiological, meteorological, demographic and geographic data, we first performed wavelet analysis and then integrated the key dynamics (i.e., mosquito population dynamics, human movement, virus transmission, and parameter estimation) into a transmission model...
December 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29216317/novel-wolbachia-transinfected-aedes-aegypti-mosquitoes-possess-diverse-fitness-and-vector-competence-phenotypes
#18
Johanna E Fraser, Jyotika Taneja De Bruyne, Iñaki Iturbe-Ormaetxe, Justin Stepnell, Rhiannon L Burns, Heather A Flores, Scott L O'Neill
Wolbachia pipientis from Drosophila melanogaster (wMel) is an endosymbiotic bacterium that restricts transmission of human pathogenic flaviviruses and alphaviruses, including dengue, Zika, and chikungunya viruses, when introduced into the mosquito vector Aedes aegypti. To date, wMel-infected Ae. aegypti have been released in field trials in 5 countries to evaluate the effectiveness of this strategy for disease control. Despite the success in establishing wMel-infected mosquitoes in wild populations, and the well-characterized antiviral capabilities of wMel, transinfecting different or additional Wolbachia strains into Ae...
December 7, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29215033/transplantation-of-a-quaternary-structure-neutralizing-antibody-epitope-from-dengue-virus-serotype-3-into-serotype-4
#19
Douglas G Widman, Ellen Young, Usha Nivarthi, Jesica A Swanstrom, Scott R Royal, Boyd L Yount, Kari Debbink, Matthew Begley, Stephanie Marcet, Anna Durbin, Aravinda M de Silva, William B Messer, Ralph S Baric
Dengue vaccine trials have revealed deficits in our understanding of the mechanisms of protective immunity, demonstrating a need to measure epitope-specific antibody responses against each DENV serotype. HmAb 5J7 binds to a complex, 3-monomer spanning quaternary epitope in the DENV3 envelope (E) protein, but it is unclear whether all interactions are needed for neutralization. Structure guided design and reverse genetics were used to sequentially transplant larger portions of the DENV3-specific 5J7 mAb epitope into dengue virus serotype 4 (DENV4)...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29211630/production-of-monoclonal-antibody-that-recognizes-zika-virus-and-other-flaviviruses-in-serum-free-conditions
#20
Fernando de Paiva Conte, Raquel de Souza Martins, Ana Carolina Dos Reis Albuquerque Cajaraville, Hilton Jorge Nascimento, Patricia Barbosa Jurgilas, Sheila Maria Barbosa de Lima, Sotiris Missailidis, Márcia Arissawa
With the recent outbreaks of Zika and Dengue virus infections in various countries worldwide, production of vaccines or diagnostic kits is an urgent public health demand. Production of a monoclonal antibody (mAb) that specifically binds to a common antigen shared by the Flavivirus genus will be necessary for new diagnostic kits or characterization and viral identity tests during vaccine development. This study aimed to cultivate, in serum-free conditions, the 4G2 hybridoma that produces an mAb, which recognizes a shared epitope from the Flavivirus genus...
December 6, 2017: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
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