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https://www.readbyqxmd.com/read/29052242/emerging-infectious-disease-outbreaks-estimating-disease-risk-in-australian-blood-donors-travelling-overseas
#1
A Coghlan, V C Hoad, C R Seed, R Lp Flower, R J Harley, D Herbert, H M Faddy
BACKGROUND AND OBJECTIVES: International travel assists spread of infectious pathogens. Australians regularly travel to South-eastern Asia and the isles of the South Pacific, where they may become infected with infectious agents, such as dengue (DENV), chikungunya (CHIKV) and Zika (ZIKV) viruses that pose a potential risk to transfusion safety. In Australia, donors are temporarily restricted from donating for fresh component manufacture following travel to many countries, including those in this study...
October 19, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29051839/external-quality-assessment-for-arbovirus-diagnostics-in-the-world-health-organization-western-pacific-region-2013-2016-improving-laboratory-quality-over-the-years
#2
Mohammad Yazid Abdad, Raynal C Squires, Sebastien Cognat, Christopher John Oxenford, Frank Konings
Arboviruses continue to pose serious public health threats in the World Health Organization (WHO) Western Pacific Region. As such, laboratories need to be equipped for their accurate detection. In 2011, to ensure test proficiency, the WHO Regional Office for the Western Pacific piloted an external quality assessment (EQA) programme for arbovirus diagnostics. By 2016, it had grown into a global programme with participation of 96 laboratories worldwide, including 25 laboratories from 19 countries, territories and areas in the Region...
July 2017: Western Pacific Surveillance and Response Journal: WPSAR
https://www.readbyqxmd.com/read/29051080/antiviral-activity-of-fenretinide-against-zika-virus
#3
Jared D Pitts, Pi-Chun Li, Melissanne de Wispelaere, Priscilla L Yang
The rapid spread of Zika virus (ZIKV) in recent years has highlighted the severe diseases associated with ZIKV infection, such as Guillain-Barré syndrome in adults and microcephaly in newborns. Yet, no vaccines or antivirals currently exist to prevent or treat ZIKV infection. We and others have previously identified N-(4-hydroxyphenyl) retinamide (fenretinide or 4-HPR) as an antiviral compound that inhibits dengue virus 2 (DV2) and other flaviviruses by limiting the steady-state accumulation of viral RNA. Here we show that 4-HPR potently inhibits Zika virus (ZIKV) in mammalian cell culture and significantly reduces both serum viremia and brain viral burden in a murine model of ZIKV infection...
October 16, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29049286/denvint-a-database-of-protein-protein-interactions-between-dengue-virus-and-its-hosts
#4
Lopamudra Dey, Anirban Mukhopadhyay
No abstract text is available yet for this article.
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29048283/unrecognized-dengue-virus-infections-in-children-western-kenya-2014-2015
#5
David M Vu, Noah Mutai, Claire J Heath, John M Vulule, Francis M Mutuku, Bryson A Ndenga, A Desiree LaBeaud
We detected a cluster of dengue virus infections in children in Kenya during July 2014-June 2015. Most cases were serotype 1, but we detected all 4 serotypes, including co-infections with 2 serotypes. Our findings implicate dengue as a cause of febrile illness in this population and highlight a need for robust arbovirus surveillance.
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29046459/hepatitis-c-virus-replication-depends-on-endosomal-cholesterol-homeostasis
#6
Ina Karen Stoeck, Ji-Young Lee, Keisuke Tabata, Inés Romero-Brey, David Paul, Philipp Schult, Volker Lohmann, Lars Kaderali, Ralf Bartenschlager
Similar to other positive-strand RNA viruses, hepatitis C virus (HCV) causes massive rearrangements of intracellular membranes, resulting in a membranous web (MW) composed of predominantly double membrane vesicles (DMVs), the presumed sites of RNA replication. DMVs are enriched for cholesterol, but mechanistic details on the source and recruitment of cholesterol to the viral replication organelle are only partially known. Here we focused on selected lipid transfer proteins implicated in direct lipid transfer at various endoplasmic reticulum (ER) - membrane contact sites...
October 18, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29045406/microrna-profiling-of-human-primary-macrophages-exposed-to-dengue-virus-identifies-mirna-3614-5p-as-antiviral-and-regulator-of-adar1-expression
#7
Mayra Diosa-Toro, Liliana Echavarría-Consuegra, Jacky Flipse, Geysson Javier Fernández, Joost Kluiver, Anke van den Berg, Silvio Urcuqui-Inchima, Jolanda M Smit
BACKGROUND: Due to the high burden of dengue disease worldwide, a better understanding of the interactions between dengue virus (DENV) and its human host cells is of the outmost importance. Although microRNAs modulate the outcome of several viral infections, their contribution to DENV replication is poorly understood. METHODS AND PRINCIPAL FINDINGS: We investigated the microRNA expression profile of primary human macrophages challenged with DENV and deciphered the contribution of microRNAs to infection...
October 18, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29044149/development-and-evaluation-of-a-rapid-molecular-diagnostic-test-for-zika-virus-infection-by-reverse-transcription-loop-mediated-isothermal-amplification
#8
Yohei Kurosaki, Danyelly Bruneska Gondim Martins, Mayuko Kimura, Andriu Dos Santos Catena, Maria Amélia Carlos Souto Maior Borba, Sandra da Silva Mattos, Haruka Abe, Rokusuke Yoshikawa, José Luiz de Lima Filho, Jiro Yasuda
The recent outbreak of Zika virus (ZIKV) disease caused an enormous number of infections in Central and South America, and the unusual increase in the number of infants born with microcephaly associated with ZIKV infection aroused global concern. Here, we developed a reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay using a portable device for the detection of ZIKV. The assay specifically detected ZIKV strains of both Asian and African genotypes without cross-reactivity with other arboviruses, including Dengue and Chikungunya viruses...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29044082/rickettsial-retinitis-direct-bacterial-infection-or-an-immune-mediated-response
#9
Rohan Chawla, Gadkar Amit Pundlik, Rama Chaudhry, Chandan Thakur
Infectious retinitis postfebrile illness is known to be caused by chikungunya, dengue, West Nile virus, Bartonella, Lyme's disease, Rift Valley fever, rickettsia, Herpes viruses etc. Rickettsia is Gram-negative bacteria transmitted by arthropods vectors. Ocular involvement is common including conjunctivitis, keratitis, anterior uveitis, panuveitis, retinitis, retinal vascular changes, and optic nerve involvement. Retinitis lesions in rickettsia can occur because of an immunological response to the bacteria or because of direct invasion and proliferation of bacteria in the inner retina...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29043660/sera-of-peruvians-with-fever-of-unknown-origins-include-viral-nucleic-acids-from-non-vertebrate-hosts
#10
Tung Gia Phan, Juana Del Valle Mendoza, Mohammadreza Sadeghi, Eda Altan, Xutao Deng, Eric Delwart
Serum samples collected from 88 Peruvians with unexplained fever were analyzed for viral sequences using metagenomics. Nucleic acids of anelloviruses, pegivirus A (GBV-C), HIV, Dengue virus, and Oropouche virus were detected. We also characterized from two sera the RNA genomes of new species of partitivirus and dicistrovirus belonging to viral families known to infect fungi or arthropod, respectively. Genomic DNA of a putative fungal cellular host could be PCR amplified from the partitivirus-containing serum sample...
October 17, 2017: Virus Genes
https://www.readbyqxmd.com/read/29040262/serological-and-spatial-analysis-of-alphavirus-and-flavivirus-prevalence-and-risk-factors-in-a-rural-community-in-western-kenya
#11
Elysse N Grossi-Soyster, Elizabeth A J Cook, William A de Glanville, Lian F Thomas, Amy R Krystosik, Justin Lee, C Njeri Wamae, Samuel Kariuki, Eric M Fèvre, A Desiree LaBeaud
Alphaviruses, such as chikungunya virus, and flaviviruses, such as dengue virus, are (re)-emerging arboviruses that are endemic in tropical environments. In Africa, arbovirus infections are often undiagnosed and unreported, with febrile illnesses often assumed to be malaria. This cross-sectional study aimed to characterize the seroprevalence of alphaviruses and flaviviruses among children (ages 5-14, n = 250) and adults (ages 15 ≥ 75, n = 250) in western Kenya. Risk factors for seropositivity were explored using Lasso regression...
October 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29038620/dengue-virus-induces-nk-cell-activation-through-trail-expression-during-infection
#12
Mariana Gandini, Fabienne Petitinga-Paiva, Cíntia Ferreira Marinho, Gladys Correa, Luzia Maria De Oliveira-Pinto, Luiz José de Souza, Rivaldo Venâncio Cunha, Claire Fernandes Kubelka, Elzinandes Leal de Azeredo
Dengue is an acute febrile illness with a wide spectrum of signs and symptoms ranging from mild to severe forms characterized by plasma leakage that can be fatal. NK cells are one of the main effectors in early infection and may play an important role in dengue pathogenesis. We investigated NK cell involvement during dengue infection. A higher frequency of NK cell subsets and TRAIL+NK cells was found in mild DF cases when compared to that in severe cases or healthy donors. NK activation markers such as CD107a and TLR3 were upregulated in patients' cells compared to those in healthy donors...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29037976/characterization-of-a-dengue-ns4b-inhibitor-originating-from-an-hcv-small-molecule-library
#13
Ilane Hernandez-Morales, Peggy Geluykens, Marleen Clynhens, Rudy Strijbos, Olivia Goethals, Sarah Megens, Nick Verheyen, Stefaan Last, David McGowan, Erwin Coesemans, Benoît De Boeck, Bart Stoops, Benoit Devogelaere, Frederik Pauwels, Koen Vandyck, Jan Martin Berke, Pierre Raboisson, Kenneth Simmen, Pedro Lory, Marnix Van Loock
Dengue is the most important mosquito-transmitted viral disease and a major global health concern. Over the last decade, dengue virus (DENV) drug discovery and development has intensified, however, this has not resulted in approved DENV-specific antiviral treatments yet. DENV and hepatitis C virus (HCV) belong to the same Flaviviridae family and, in contrast to DENV, antiviral treatments for HCV have been licensed. Therefore, applying the knowledge gained on anti-HCV drugs may foster the discovery and development of dengue antiviral drugs...
October 13, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29036392/update-from-the-advisory-committee-on-immunization-practices
#14
Sean T O'Leary, David W Kimberlin
The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group has 15 voting members, and each member's term is 4 years. ACIP members and Centers for Disease Control and Prevention (CDC) staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and clinical trial results. Representatives from the American Academy of Pediatrics (Carrie L...
September 25, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29035789/an-easy-way-to-detect-dengue-virus-using-nanoparticle-antibody-conjugates
#15
Caroline R Basso, Claudia C Tozato, Bruno P Crulhas, Gustavo R Castro, João Pessoa A Junior, Valber A Pedrosa
The aim of the present research is to propose a new method based on localized surface plasmon resonance (LSPR) for fast dengue virus detection. A pool with four dengue serotypes (DENV-1, -2, -3, -4) was detected through antigen-antibody binding using gold nanoparticles (AuNPs) as signaling antibody carriers. Such result was confirmed through surface plasmon resonance (SPR), transmission electron microcopy (TEM), and dynamic light scattering (DLS) techniques. The limit of detection was calculated for TCID50 10(7) demonstrating a linear correlation between viral concentration and number of cells with an r(2) value of > 0...
October 13, 2017: Virology
https://www.readbyqxmd.com/read/29035317/systematic-review-land-cover-meteorological-and-socioeconomic-determinants-of-aedes-mosquito-habitat-for-risk-mapping
#16
REVIEW
Mohamed F Sallam, Chelsea Fizer, Andrew N Pilant, Pai-Yei Whung
Asian tiger and yellow fever mosquitoes (Aedes albopictus and Ae. aegypti) are global nuisances and are competent vectors for viruses such as Chikungunya (CHIKV), Dengue (DV), and Zika (ZIKV). This review aims to analyze available spatiotemporal distribution models of Aedes mosquitoes and their influential factors. A combination of five sets of 3-5 keywords were used to retrieve all relevant published models. Five electronic search databases were used: PubMed, MEDLINE, EMBASE, Scopus, and Google Scholar through 17 May 2017...
October 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29031635/correlation-of-altered-expression-of-a-long-non-coding-rna-neat1-in-peripheral-blood-mononuclear-cells-with-dengue-disease-progression
#17
Abhay Deep Pandey, Saptamita Goswami, Shweta Shukla, Shaoli Das, Suman Ghosal, Manisha Pal, Bhaswati Bandyopadhyay, Vishnampettai Ramachandran, Nandita Basu, Vikas Sood, Priyanka Pandey, Jayprokas Chakrabarti, Sudhanshu Vrati, Arup Banerjee
The association of long non-coding RNAs (lncRNAs) with dengue disease progression is currently unknown. Therefore, the present study aimed to identify lncRNAs in different categories of dengue patients and evaluate their association with dengue disease progression. Herein, we examined the expression profiles of lncRNAs and protein-coding genes between other febrile illness (OFI) and different grade of dengue patients through high-throughput RNA sequencing. We identified Nuclear Enriched Abundant Transcript 1 (NEAT1) as one of the differentially expressed lncRNAs (adjusted P ≤ 0...
October 12, 2017: Journal of Infection
https://www.readbyqxmd.com/read/29031286/surveillance-of-vector-borne-infections-chikungunya-dengue-and-malaria-in-bo-sierra-leone-2012-2013
#18
Donald F Dariano, Chris R Taitt, Kathryn H Jacobsen, Umaru Bangura, Alfred S Bockarie, Moses J Bockarie, Joseph Lahai, Joseph M Lamin, Tomasz A Leski, Chadwick Yasuda, David A Stenger, Rashid Ansumana
Malaria remains a significant cause of morbidity and mortality in West Africa, but the contribution of other vector-borne infections (VBIs) to the burden of disease has been understudied. We used rapid diagnostic tests (RDTs) for three VBIs to test blood samples from 1,795 febrile residents of Bo City, Sierra Leone, over a 1-year period in 2012-2013. In total, 24% of the tests were positive for malaria, fewer than 5% were positive for markers of dengue virus infection, and 39% were positive for IgM directed against chikungunya virus (CHIKV) or a related alphavirus...
October 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29031282/dengue-virus-serotypes-1-and-2-responsible-for-major-dengue-outbreaks-in-nepal-clinical-laboratory-and-epidemiological-features
#19
Shyam Prakash Dumre, Renu Bhandari, Geeta Shakya, Sanjaya Kumar Shrestha, Mahamoud Sama Cherif, Prakash Ghimire, Chonticha Klungthong, In-Kyu Yoon, Kenji Hirayama, Kesara Na-Bangchang, Stefan Fernandez
Dengue virus (DENV) is expanding toward previously nonendemic areas. DENV has recently been introduced in Nepal with limited information. We report the clinical features and serotype distribution of DENV in Nepal during the 2010 outbreaks. A total of 1,215 clinical dengue cases at two major hospitals of central and western Nepal were investigated. Demographic, clinical, and laboratory parameters were recorded. Serum specimens were tested for DENV by IgM/IgG enzyme-linked immunosorbent assays (ELISAs) and reverse transcription polymerase chain reaction (RT-PCR)...
October 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29031073/discovery-of-novel-diarylpyrazolylquinoline-derivatives-as-potent-anti-dengue-virus-agents
#20
Jin-Ching Lee, Chin-Kai Tseng, Chun-Kuang Lin, Chih-Hua Tseng
A number of diarylpyrazolylquinoline derivatives were synthesized and evaluated for their anti-dengue virus (DENV) activity. Among them, 6-fluoro-2-(1-(4-fluorophenyl)-3- (4-methoxyphenyl)-1H-pyrazol-5-yl)quinoline (11c), 2-[1,3-bis(4-methoxyphenyl)-1H-pyrazol- 5-yl]-6-fluoroquinoline (12c), and 4-[5-(6-fluoroquinolin-2-yl)-3-(4-methoxyphenyl)-1H-pyrazol- 1-yl]benzenesulfonamide (13c) exhibited approximately 10-folds more active anti-DENV-2 activity (IC50 of 1.36, 1.09 and 0.81 μM, respectively) than that of ribavirin (IC50 = 12...
October 3, 2017: European Journal of Medicinal Chemistry
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