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https://www.readbyqxmd.com/read/29677500/raman-spectral-analysis-for-rapid-screening-of-dengue-infection
#1
T Mahmood, H Nawaz, A Ditta, M I Majeed, M A Hanif, N Rashid, H N Bhatti, H F Nargis, M Saleem, F Bonnier, H J Byrne
Infection with the dengue virus is currently clinically detected according to different biomarkers in human blood plasma, commonly measured by enzyme linked immunosorbent assays, including non-structural proteins (Ns1), immunoglobulin M (IgM) and immunoglobulin G (IgG). However, there is little or no mutual correlation between the biomarkers, as demonstrated in this study by a comparison of their levels in samples from 17 patients. As an alternative, the label free, rapid screening technique, Raman spectroscopy has been used for the characterisation/diagnosis of healthy and dengue infected human blood plasma samples...
April 11, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29677482/allosteric-ligands-for-the-pharmacologically-important-flavivirus-target-ns5-from-zinc-database-based-on-pharmacophoric-points-free-energy-calculations-and-dynamics-correlation
#2
Abbas Khan, Shoaib Saleem, Muhammad Idrees, Syed Shujait Ali, Muhammad Junaid, Aman Chandra Kaushik, Dong-Qing Wei
Dengue virus belongs to a group of human pathogens, which causes different diseases, dengue hemorrhagic fever and dengue shock syndrome in humans. It possesses RNA as a genetic material and is replicated with the aid of NS5 protein. RNA-dependent RNA polymerase (RdRp) is an important domain of NS5 in the replication of that virus. The catalytic process activity of RdRp is making it an important target for antiviral chemical therapy. To date, No FDA drug has been approved and marketed for the treatment of diseases caused by Dengue virus...
April 11, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29674002/dengue-virus-ns2-and-ns4-minor-proteins-mammoth-roles
#3
REVIEW
Sindhoora Bhargavi Gopala Reddy, Wei-Xin Chin, Nanjunda Swamy Shivananju
Despite the ever increasing global incidence of dengue fever, there are no specific chemotherapy regimens for its treatment. Structural studies on dengue virus (DENV) proteins have revealed potential drug targets. Major DENV proteins such as the envelope protein and non-structural (NS) proteins 3 and 5 have been extensively investigated in antiviral studies, but with limited success in vitro. However, the minor NS proteins NS2 and NS4 have remained relatively underreported. Emerging evidence indicating their indispensable roles in virus propagation and host immunomodulation should encourage us to target these proteins for drug discovery...
April 16, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29673347/structure-activity-relationship-sar-and-quantitative-structure-activity-relationship-qsar-studies-showed-plant-flavonoids-as-potential-inhibitors-of-dengue-ns2b-ns3-protease
#4
Muhammad Waseem Sarwar, Adeel Riaz, Syed Muhammad Raihan Dilshad, Ahmed Al-Qahtani, Muhammad Shah Nawaz-Ul-Rehman, Muhammad Mubin
BACKGROUND: Due to dengue virus disease, half of the world population is at severe health risk. Viral encoded NS2B-NS3 protease complex causes cleavage in the nonstructural region of the viral polyprotein. The cleavage is essentially required for fully functional viral protein. It has already been reported that if function of NS2B-NS3 complex is disrupted, viral replication is inhibited. Therefore, the NS2B-NS3 is a well-characterized target for designing antiviral drug. RESULTS: In this study docking analysis was performed with active site of dengue NS2B-NS3 protein with selected plant flavonoids...
April 19, 2018: BMC Structural Biology
https://www.readbyqxmd.com/read/29672710/dengue-virus-not-detected-in-human-semen
#5
James S Molton, Isaac Low, Milly Ming Ju Choy, Pauline Poh Kim Aw, Martin L Hibberd, Paul A Tambyah, Annelies Wilder-Smith
Zika and Ebola viruses can persist in semen and pose a risk for sexual transmission. To determine if dengue virus, another flavivirus, is similarly detectable in semen, we performed dengue PCR on semen in five patients with acute dengue virus infection. All five tested negative, suggesting that dengue does not pose a risk for sexual transmission.
January 1, 2018: Journal of Travel Medicine
https://www.readbyqxmd.com/read/29672522/nucleobases-and-corresponding-nucleosides-display-potent-antiviral-activities-against-dengue-virus-possibly-through-viral-lethal-mutagenesis
#6
Li Qiu, Steven E Patterson, Laurent F Bonnac, Robert J Geraghty
Dengue virus affects millions of people worldwide each year. To date, there is no drug for the treatment of dengue-associated disease. Nucleosides are effective antivirals and work by inhibiting the accurate replication of the viral genome. Nucleobases offer a cheaper alternative to nucleosides for broad antiviral applications. Metabolic activation of nucleobases involves condensation with 5-phosphoribosyl-1-pyrophosphate to give the corresponding nucleoside-5'-monophosphate. This could provide an alternative to phosphorylation of a nucleoside, a step that is often rate limiting and inefficient in activation of nucleosides...
April 19, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29666784/the-immune-responses-of-the-animal-hosts-of-west-nile-virus-a-comparison-of-insects-birds-and-mammals
#7
REVIEW
Laura R H Ahlers, Alan G Goodman
Vector-borne diseases, including arboviruses, pose a serious threat to public health worldwide. Arboviruses of the flavivirus genus, such as Zika virus (ZIKV), dengue virus, yellow fever virus (YFV), and West Nile virus (WNV), are transmitted to humans from insect vectors and can cause serious disease. In 2017, over 2,000 reported cases of WNV virus infection occurred in the United States, with two-thirds of cases classified as neuroinvasive. WNV transmission cycles through two different animal populations: birds and mosquitoes...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29666658/phylogenetic-analysis-of-dengue-virus-in-bangkalan-madura-island-east-java-province-indonesia
#8
Teguh Hari Sucipto, Tomohiro Kotaki, Kris Cahyo Mulyatno, Siti Churrotin, Amaliah Labiqah, Soegeng Soegijanto, Masanori Kameoka
Dengue virus (DENV) infection is a major health issue in tropical and subtropical areas. Indonesia is one of the biggest dengue endemic countries in the world. In the present study, the phylogenetic analysis of DENV in Bangkalan, Madura Island, Indonesia, was performed in order to obtain a clearer understanding of its dynamics in this country. A total of 359 blood samples from dengue-suspected patients were collected between 2012 and 2014. Serotyping was conducted using a multiplex Reverse Transcriptase-Polymerase Chain Reaction and a phylogenetic analysis of E gene sequences was performed using the Bayesian Markov chain Monte Carlo (MCMC) method...
2018: Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29666420/the-sting-behind-dengue-virus-infection
#9
Katharine Wrighton
No abstract text is available yet for this article.
April 17, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/29665375/luteolin-escape-mutants-of-dengue-virus-map-to-prm-and-ns2b-and-reveal-viral-plasticity-during-maturation
#10
Minhua Peng, Crystall Marie Dawn Swarbrick, Kitti Wing-Ki Chan, Dahai Luo, Wei Zhang, Xiaoping Lai, Geng Li, Subhash G Vasudevan
We previously showed that luteolin, a well-known plant-derived component found in the "heat clearing" class of Traditional Chinese Medicine (TCM) herbs, is an uncompetitive inhibitor (Ki 58.6 μM) of the host proprotein convertase furin, an endoprotease that is required for maturation of flaviviruses in the trans-Golgi compartment. Luteolin also weakly inhibited recombinant dengue virus NS2B/NS3 protease (Ki 140.36 μM) non-competitively. In order to further explore the mechanism of inhibition we isolated resistant mutants by continuous passaging of DENV2 in the presence of increasing concentrations of luteolin...
April 14, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29665374/spectrum-of-activity-testing-for-therapeutics-against-all-four-dengue-virus-serotypes-in-ag129-mouse-models-proof-of-concept-studies-with-the-adenosine-nucleoside-inhibitor-nitd-008
#11
Gregg N Milligan, Mellodee White, Diana Zavala, Richard B Pyles, Vanessa V Sarathy, Alan D T Barrett, Nigel Bourne
Dengue is a mosquito-borne disease of global public health importance caused by four genetically and serologically related viruses (DENV-1 to DENV-4). Efforts to develop effective vaccines and therapeutics for dengue have been slowed by the paucity of preclinical models that mimic human disease. DENV-2 models in interferon receptor deficient AG129 mice were an important advance but only allowed testing against a single DENV serotype. We have developed complementary AG129 mouse models of severe disseminated dengue infection using strains of the other three DENV serotypes...
April 14, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29663859/factors-contributing-to-and-strategies-to-combat-emerging-arboviruses
#12
David Michael Callender
Less than half a century ago infectious diseases appeared to be destined to be extinguished via as a culmination of medical triumphs. As focus turned towards combating non-communicable diseases, emerging and re-emerging diseases (EIDs) have bloomed from those ashes. Five epidemic mosquito-borne arboviruses (Yellow Fever virus (YFV), Dengue virus, West Nile virus, Chikungunya virus, and Zika virus) have emerged in the recent past. Arboviruses are of the utmost importance with respect to EIDs due to intensive growth of globalisation, arthropod urban fitness/adaption, and environmental changes...
April 17, 2018: Global Public Health
https://www.readbyqxmd.com/read/29662096/variation-in-wolbachia-effects-on-aedes-mosquitoes-as-a-determinant-of-invasiveness-and-vectorial-capacity
#13
Jessica G King, Caetano Souto-Maior, Larissa M Sartori, Rafael Maciel-de-Freitas, M Gabriela M Gomes
Wolbachia has been introduced into Aedes aegypti mosquitoes to control the spread of arboviruses, such as dengue, chikungunya and Zika. Studies showed that certain Wolbachia strains (such as wMel) reduce replication of dengue viruses in the laboratory, prompting the release of mosquitoes carrying the bacterium into the field, where vectorial capacity can be realistically assessed in relation to native non-carriers. Here we apply a new analysis to two published datasets, and show that wMel increases the mean and the variance in Ae...
April 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29661824/development-of-dengue-virus-serotype-specific-ns1-capture-assays-for-the-rapid-and-highly-sensitive-identification-of-the-infecting-serotype-in-human-sera
#14
Katharina Röltgen, Natalie Rose, Alessia Ruggieri, Louisa Warryn, Nicole Scherr, Carlos Augusto Pinho-Nascimento, Marco Tamborrini, Thomas Jaenisch, Gerd Pluschke
Dengue fever can be caused by one of four distinct dengue virus (DENV) serotypes that cocirculate in many parts of the world. Point of care serotype-specific nonstructural protein-1 (NS1) capture assays for the rapid serotyping of DENV in human sera would greatly support epidemiological surveillance and potentially also prognosis in individual patients. To ensure both serotype specificity and broad coverage of variants within serotypes, we have applied an innovative approach for the generation and selection of serotype-specific anti-NS1 mAbs...
April 16, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29661212/numerical-modeling-of-mosquito-population-dynamics-of-aedes-aegypti
#15
William M S Yamashita, Shyam S Das, Grigori Chapiro
BACKGROUND: The global incidences of dengue virus have increased the interest in studying and understanding the mosquito population dynamics. It is predominantly spread by Aedes aegypti in the tropical and sub-tropical countries in the world. Understanding these dynamics is important for public health in countries where climatic and environmental conditions are favorable for the propagation of these diseases. For this reason, a new model has been proposed to investigate the population dynamics of mosquitoes in a city...
April 16, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29660363/comparison-analysis-of-micrornas-in-response-to-dengue-virus-type-2-infection-between-the-vero-cell-adapted-strain-and-its-source-the-clinical-c6-36-isolated-strain
#16
Jiajia Yang, Yao Lin, Liming Jiang, Juemin Xi, Xiaodan Wang, Jiaoqiong Guan, Junying Chen, Yue Pan, Jia Luo, Chao Ye, Qiangming Sun
To elucidate the differences in microRNAs during dengue virus infection between Vero cell-adapted strain (DENV-2-Vero) and its source, the clinical C6/36 isolated strain (DENV-2-C6/36), a comparison analysis was performed in Vero cells by high throughput sequencing. The results showed that the expression of 16 known and 3 novel miRNAs exhibited marked differences. 5 known miRNAs were up-regulated in DENV-2-C6/36 group, while 11 known microRNAs were down-regulated in DENV-2-Vero group. The GO enrichment and KEGG pathway analysis showed that there was a distinct difference in regulating viral replication between two strains...
April 13, 2018: Virus Research
https://www.readbyqxmd.com/read/29659944/factors-related-to-aedes-aegypti-diptera-culicidae-populations-and-temperature-determine-differences-on-life-history-traits-with-regional-implications-in-disease-transmission
#17
Evangelina Muttis, Agustin Balsalobre, Ailen Chuchuy, Carolina Mangudo, Alexander T Ciota, Laura D Kramer, María Victoria Micieli
Aedes aegypti (L.) (Diptera: Culicidae) is a vector of many medically significant viruses in the Americas, including dengue virus, chikungunya virus, and Zika virus. Traits such as longevity, fecundity, and feeding behavior contribute to the ability of Ae. aegypti to serve as a vector of these pathogens. Both local environmental factors and population genetics could contribute to variability in these traits. We performed a comparative study of Ae. aegypti populations from four geographically and environmentally distinct collection sites in Argentina in which the cohorts from each population were held at temperature values simulating a daily cycle, with an average of 25°C in order to identify the influence of population on life-history traits...
April 11, 2018: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29659904/coinfection-with-zika-and-dengue-viruses-results-in-preferential-zika-transmission-by-vector-bite-to-vertebrate-host
#18
Barbara Aparecida Chaves, Alessandra Silva Orfano, Paula Monalisa Nogueira, Nilton Barnabe Rodrigues, Thais Bonifácio Campolina, Rafael Nacif-Pimenta, Ana Clara Araújo Machado Pires, Ademir Bentes Vieira Júnior, Andréia da Costa Paz, Evelyn Beatriz da Costa Vaz, Maria das Graças Vale Barbosa Guerra, Breno Melo Silva, Fabrício Freire de Melo, Douglas Eric Norris, Marcus Vinícius Guimarães de Lacerda, Paulo Filemon Paolucci Pimenta, Nágila Francinete Costa Secundino
Background: Several tropical cities are permissive to Aedes aegypti and DENV endemicity, and have allowed for invasion and circulation of ZIKV in the same areas. People living in endemic regions have been simultaneously infected with two or more arboviruses. Methods: Ae. aegypti mosquitoes from Manaus, capital city of the Amazonas State, were coinfected with circulating strains of DENV and ZIKV. The coinfected vectors were allowed to bite BALB/c mice. Results: Ae...
April 6, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29659571/allostery-in-the-dengue-virus-ns3-helicase-insights-into-the-ntpase-cycle-from-molecular-simulations
#19
Russell B Davidson, Josie Hendrix, Brian J Geiss, Martin McCullagh
The C-terminus domain of non-structural 3 (NS3) protein of the Flaviviridae viruses (e.g. HCV, dengue, West Nile, Zika) is a nucleotide triphosphatase (NTPase) -dependent superfamily 2 (SF2) helicase that unwinds double-stranded RNA while translocating along the nucleic polymer. Due to these functions, NS3 is an important target for antiviral development yet the biophysics of this enzyme are poorly understood. Microsecond-long molecular dynamic simulations of the dengue NS3 helicase domain are reported from which allosteric effects of RNA and NTPase substrates are observed...
April 16, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29655694/tatanan-a-from-the-acorus-calamus-l-root-inhibited-dengue-virus-proliferation-and-infections
#20
Xingang Yao, Yun Ling, Songxin Guo, Wenyu Wu, Shijun He, Qing Zhang, Min Zou, Kutty Selva Nandakumar, Xiaoguang Chen, Shuwen Liu
BACKGROUND: Acorus calamus l. (Acoraceae) is a well-known traditional Chinese medicinal plant, whose root are historically mainly used to treat neurodegenerative diseases, and for cholera treatment. This datum strongly indicates the antimicrobial activity of A. calamus. PURPOSE: Our goal is to find the active constituents of A. calamus to treat dengue virus (DENV) infections, and to study the effects and mechanisms of these active substances. METHODS: The root of A...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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