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https://www.readbyqxmd.com/read/29928791/size-adaptable-13-channel-receive-array-for-brain-mri-in-human-neonates-at-3-t
#1
Nibardo Lopez Rios, Alexandru Foias, Gregory Lodygensky, Mathieu Dehaes, Julien Cohen-Adad
Neonatal brain injury suffered by preterm infants and newborns with some medical conditions can cause significant neurodevelopmental disabilities. MRI is a preferred method to detect these accidents and perform in vivo evaluation of the brain. However, the commercial availability and optimality of receive coils for the neonatal brain is limited, which in many cases leads to images lacking in quality. As extensively demonstrated, receive arrays closely positioned around the scanned part provide images with high signal-to-noise ratios (SNRs)...
June 21, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29926973/heart-rate-respiratory-rate-apnoeas-and-peripheral-arterial-oxygen-saturation-in-healthy-term-neonates-during-quiet-sleep
#2
B Bohnhorst, K Seidel, C Böhne, C Peter, S Pirr
AIM: This study compiled percentiles for cardiorespiratory parameters in healthy term neonates during quiet sleep. METHODS: We enrolled 215 healthy term neonates born at Hannover Medical School, Germany, between October 2011 and March 2013. They were prospectively observed on the maternity ward at a median age of two days using six-hour recordings of pulse oximeter plethysmography, oxygen saturation, thoracic breathing movements and electrocardiogram during sleep in a supine position...
June 21, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29926476/formula-versus-donor-breast-milk-for-feeding-preterm-or-low-birth-weight-infants
#3
REVIEW
Maria Quigley, Nicholas D Embleton, William McGuire
BACKGROUND: When sufficient maternal breast milk is not available, alternative forms of enteral nutrition for preterm or low birth weight (LBW) infants are donor breast milk or artificial formula. Donor breast milk may retain some of the non-nutritive benefits of maternal breast milk for preterm or LBW infants. However, feeding with artificial formula may ensure more consistent delivery of greater amounts of nutrients. Uncertainty exists about the balance of risks and benefits of feeding formula versus donor breast milk for preterm or LBW infants...
June 20, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29926474/neonatal-interventions-for-preventing-cerebral-palsy-an-overview-of-cochrane-systematic-reviews
#4
REVIEW
Emily Shepherd, Rehana A Salam, Philippa Middleton, Shanshan Han, Maria Makrides, Sarah McIntyre, Nadia Badawi, Caroline A Crowther
BACKGROUND: Cerebral palsy is an umbrella term that encompasses disorders of movement and posture attributed to non-progressive disturbances occurring in the developing foetal or infant brain. As there are diverse risk factors and aetiologies, no one strategy will prevent cerebral palsy. Therefore, there is a need to systematically consider all potentially relevant interventions for prevention. OBJECTIVES: PrimaryTo summarise the evidence from Cochrane Systematic Reviews regarding effects of neonatal interventions for preventing cerebral palsy (reducing cerebral palsy risk)...
June 20, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29926376/clinical-outcomes-following-icsi-cycles-using-surgically-recovered-sperm-and-the-impact-of-maternal-age-2004-2015-sart-cors-registry
#5
A M Mahesan, S Sadek, V Moussavi, T Vazifedan, A Majeed, T Cunningham, S Oehninger, S Bocca
PURPOSE: The aims of this study were (1) to evaluate clinical outcomes after ICSI cycles using surgically recovered sperm and (2) to assess the influence of maternal age on those outcomes. METHODS: A retrospective cohort study of 24,763 IVF cycles of fresh autologous oocytes and ICSI using surgically recovered sperm reported to the SART CORS database from 2004 to 2015. RESULTS AND CONCLUSIONS: Older women had significantly longer stimulation (p < 0...
June 20, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29926375/brief-co-incubation-of-gametes-benefits-the-outcomes-of-newborns
#6
Ruiqi Li, Songbang Ou, Nengyong Ouyang, Lingyan Zheng, Qingxue Zhang, Dongzi Yang, Wenjun Wang
PURPOSE: The objective of this study was to determine whether ammonium accumulates in IVF media during fertility process and whether the brief co-incubation of gametes (bIVF) benefited the outcomes of newborns. METHODS: Ammonium levels in IVF media during gamete co-incubation were measured and the effects of bIVF on neonatal outcomes were evaluated retrospectively in this study. RESULTS: A total of 609 live newborns cycles were included in this study...
June 20, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29925540/hypoxemic-and-hyperoxemic-likelihood-in-pulse-oximetry-ranges-nicu-observational-study
#7
Thomas E Bachman, Christopher J L Newth, Narayan P Iyer, Patrick A Ross, Robinder G Khemani
OBJECTIVE: Describe the likelihood of hypoxemia and hyperoxemia across ranges of oxygen saturation (SpO2 ), during mechanical ventilation with supplemental oxygenation. DESIGN: Retrospective observational study. SETTING: University affiliated tertiary care neonatal intensive care unit. PATIENTS: Two groups of neonates based on postmenstrual age (PMA): <32 weeks (n=104) and >36 weeks (n=709). MAIN MEASURES: Hypoxemia was defined as a PaO2 <40 mm Hg, hyperoxemia as a PaO2 of >99 mm Hg and normoxemia as a PaO2 of 50-80 mm Hg...
June 20, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29925539/dose-interval-study-of-a-dual-probiotic-in-preterm-infants
#8
Claire Watkins, Kiera Murphy, Eugene M Dempsey, Carol Anne O'Shea, Brendan Paul Murphy, Paul W O'Toole, R Paul Ross, Catherine Stanton, C Anthony Ryan
OBJECTIVE: The objective of this study was to investigate the appropriate dosing interval of a probiotic (Infloran) given daily, biweekly and weekly in preterm infants <32 weeks' gestation. METHODS: There were 8 infants in the daily group, 8 infants in the biweekly group and 10 infants in the weekly group, all born between 25 and 32 weeks' gestation. The control group consisted of 12 preterm infants who did not receive the probiotic. Infloran (250 mg/capsule), containing Bifidobacterium bifidum (1×109 colony-forming unit (CFU)) and Lactobacillus acidophilus (1×109 CFU), was administered in 2...
June 20, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29925380/associations-between-mixtures-of-urinary-phthalate-metabolites-with-gestational-age-at-delivery-a-time-to-event-analysis-using-summative-phthalate-risk-scores
#9
Jonathan Boss, Jingyi Zhai, Max T Aung, Kelly K Ferguson, Lauren E Johns, Thomas F McElrath, John D Meeker, Bhramar Mukherjee
BACKGROUND: Preterm birth is a significant public health concern and exposure to phthalates has been shown to be associated with an increased odds of preterm birth. Even modest reductions in gestational age at delivery could entail morbid consequences for the neonate and analyzing data with this additional information may be useful. In the present analysis, we consider gestational age at delivery as our outcome of interest and examine associations with multiple phthalates. METHODS: Women were recruited early in pregnancy as part of a prospective, longitudinal birth cohort at the Brigham and Women's Hospital in Boston, Massachusetts...
June 20, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29924738/obstetrical-maternal-and-neonatal-outcomes-in-pregnancies-affected-by-muscular-dystrophy
#10
Adriano Petrangelo, Eman Alshehri, Nicholas Czuzoj-Shulman, Haim A Abenhaim
OBJECTIVE: Pregnancies in women affected by a muscular dystrophy are at an increased risk of adverse maternal and neonatal outcomes due to the effect of the disease on the muscular, cardiac and respiratory systems. We sought to evaluate the risk of adverse outcomes within a large population-based cohort study. METHODS: We used the data extracted from the Nationwide Inpatient Sample (NIS) to conduct a retrospective population-based cohort study consisting of over 12 million births that occurred in the United States between 1999 and 2013...
June 20, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29924737/outcomes-in-oligohydramnios-the-role-of-etiology-in-predicting-pulmonary-morbidity-mortality
#11
Ashley Hesson, Elizabeth Langen
OBJECTIVE: Early-onset oligohydramnios is typically secondary to renal-urinary anomalies (RUA) or preterm premature rupture of membranes (PPROM). We compared neonatal pulmonary outcomes between these etiologies. METHODS: We conducted a retrospective cohort study of women with oligohydramnios identified before 24 completed weeks of gestation attributed to either PPROM or RUA. Patients were excluded if other fetal anomalies were noted. Respiratory morbidity was assessed by the need for oxygen at 36 corrected weeks or at hospital discharge...
June 20, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29924388/fat-supplementation-of-human-milk-for-promoting-growth-in-preterm-infants
#12
REVIEW
Emma A Amissah, Julie Brown, Jane E Harding
BACKGROUND: As preterm infants do not experience the nutrient accretion and rapid growth phase of the third trimester of pregnancy, they are vulnerable to postnatal nutritional deficits, including of fat. Consequently, they require higher fat intakes compared to their full term counterparts to achieve adequate growth and development. Human milk fat provides the major energy needs of the preterm infant and also contributes to several metabolic and physiological functions. Although human milk has many benefits for this population, its fat content is highly variable and may be inadequate for their optimum growth and development...
June 19, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29923534/a-cohort-study-on-risk-factors-for-preterm-births-in-rural-gujarat
#13
Poonam Trivedi, Deepak Saxena, Tapasvi Puwar, Shital Savaliya, Parthasarathi Ganguly
Background: Prematurity is one of the leading causes of neonatal and under-five mortalities globally and also in India. It is an important determinant of short- and long-term morbidities in infants and children. Unfortunately, risk factors of majority of preterm births (PTBs) remain unexplained which calls for appropriate action. There is a dearth of community-based research on PTB and its risk factors, especially in high burden countries like India. Objectives: The objective of the study was to explore different risk factors for PTB...
April 2018: Indian Journal of Public Health
https://www.readbyqxmd.com/read/29922491/immunological-emergency-in-neonate-case-report-and-role-of-early-screening
#14
Veronica Mugarab Samedi, Amy Shafey, Essa Al Awad, Luis Murguia Favela
Healthy looking newborns may have severe combined immunodeficiency (SCID), and neonatologists frequently are the first physicians to encounter these patients. Physicians usually have a high index of suspicion for this condition in presence of certain risk factors (unexplained infants' deaths, consanguinity); however, >80% of infants with SCID have no positive family history. A timely diagnosis of this condition is crucial in decreasing both mortality and morbidity. The only way to detect SCID prior to the onset of infections is newborn screening (NBS)...
April 2018: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/29922135/music-from-the-very-beginning-a-neuroscience-based-framework-for-music-as-therapy-for-preterm-infants-and-their-parents
#15
Friederike Barbara Haslbeck, Dirk Bassler
Human and animal studies demonstrate that early auditory experiences influence brain development. The findings are particularly crucial following preterm birth as the plasticity of auditory regions, and cortex development are heavily dependent on the quality of auditory stimulation. Brain maturation in preterm infants may be affected among other things by the overwhelming auditory environment of the neonatal intensive care unit (NICU). Conversely, auditory deprivation, (e.g., the lack of the regular intrauterine rhythms of the maternal heartbeat and the maternal voice) may also have an impact on brain maturation...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29921737/selection-bias-and-outcomes-for-preterm-neonates
#16
Kerryn Atwell, Emily Callander, Daniel Lindsay, Peter Blake Marshall, Scott Adam Morris
BACKGROUND: Reported survival and neurodevelopmental outcomes at 23 weeks' gestation are based on the infants admitted to NICUs. In this study, we aim to describe the association between clinical characteristics and admission to NICU at 23, 24 and 25 weeks' gestation. METHODS: Cohort data from 2 national databases enabled comparison of the clinical characteristics all Australian births and all NICU admissions during 2010-2013 at 23, 24, and 25 weeks' gestation. RESULTS: NICU admission occurred in 15% of all births at 23 weeks, in comparison with 49% at 24 weeks and 64% at 25 weeks...
June 19, 2018: Pediatrics
https://www.readbyqxmd.com/read/29920326/effect-of-neonatal-hyperoxia-followed-by-concentrated-ambient-ultrafine-particle-exposure-on-cumulative-learning-in-c57bl-6j-mice
#17
Keith Morris-Schaffer, Marissa Sobolewski, Joshua L Allen, Elena Marvin, Min Yee, Manish Arora, Michael A O'Reilly, Deborah A Cory-Slechta
Hyperoxia during treatment for prematurity may enhance susceptibility to other risk factors for adverse brain development, such as air pollution exposure, as both of these risk factors have been linked to a variety of adverse neurodevelopmental outcomes. This study investigated the combined effects of neonatal hyperoxia followed by inhalation of concentrated ambient ultrafine particles (CAPS, <100 nm in aerodynamic diameter) on learning. C57BL/6 J mice were birthed into 60% oxygen until postnatal day (PND) 4 and subsequently exposed to filtered air or to CAPS using the Harvard University Concentrated Ambient Particle System (HUCAPS) from PND 4-7 and 10-13...
June 18, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29917228/title-reduced-blood-volume-decreases-cerebral-blood-flow-in-preterm-piglets
#18
Yvonne A Eiby, Nicole Y Shrimpton, Ian M R Wright, Eugenie R Lumbers, Paul B Colditz, Greg J Duncombe, Barbara E Lingwood
Preterm infants often have impaired cardiovascular function that may contribute to poor neurodevelopmental outcomes. The study aimed to determine the effects of reduced blood volume on cardiovascular function, including cerebral blood flow in preterm and term piglets. In preterm (97/115d) and term piglets, up to 10% of the estimated blood volume was removed. Removal of blood was ceased if MAP dropped below 20 mmHg. Heart rate, cardiac contractility and relaxation, cardiac output, mean arterial pressure (MAP), and cerebral blood flow were measured at baseline and again after blood volume reduction...
June 19, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29916044/perinatal-prediction-model-for-severe-intraventricular-hemorrhage-and-the-effect-of-early-postnatal-acidosis
#19
Juyoung Lee, Mee Hong, Sook Kyung Yum, Jung Hyun Lee
PURPOSE: Severe acidosis is one of the strongest predictors of neurologic outcomes in full-term infants with suspected hypoxic-ischemic encephalopathy. However, the relative importance of acidosis as a predictor of outcomes in preterm infants is much less clear. The goals of the present study were to examine the association between postnatal acidosis and severe intraventricular hemorrhage (IVH) and to establish a new score model including acid-base status after birth for predicting the risk of this morbidity...
June 18, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29915747/audit-of-emergency-obstetric-referrals-from-a-secondary-level-hospital-in-haryana-north-india
#20
Shashi Kant, Ravneet Kaur, Sumit Malhotra, Partha Haldar, Akhil Dhanesh Goel
Background: The maternal mortality ratio in India is high. An effective emergency obstetric care (EmOC) strategy has been identified as a priority to reduce maternal deaths. Since the capacity of different levels of public health facilities to provide EmOC is varied, an effective referral system is crucial. However, few studies have evaluated the functioning and quality of referral systems in India. A systematic monitoring of referrals helps to identify current gaps in the provision of essential obstetric care...
January 2018: Journal of Family Medicine and Primary Care
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