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https://www.readbyqxmd.com/read/29351621/familial-paroxysmal-kinesigenic-dyskinesia-is-associated-with-mutations-in-the-kcna1-gene
#1
Xiao-Meng Yin, Jing-Han Lin, Li Cao, Tong-Mei Zhang, Sheng Zeng, Kai-Lin Zhang, Wo-Tu Tian, Zheng-Mao Hu, Nan Li, Jun-Ling Wang, Ji-Feng Guo, Ruo-Xi Wang, Kun Xia, Zhuo-Hua Zhang, Fei Yin, Jing Peng, Wei-Ping Liao, Yong-Hong Yi, Jing-Yu Liu, Zhi-Xian Yang, Zhong Chen, Xiao Mao, Xin-Xiang Yan, Hong Jiang, Lu Shen, Sheng-Di Chen, Li-Ming Zhang, Bei-Sha Tang
No abstract text is available yet for this article.
January 16, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29351394/bile-acid-profiles-within-the-enterohepatic-circulation-in-a-diabetic-rat-model-after-bariatric-surgeries
#2
Meng Wei, Yi Shao, Qiao-Ran Liu, Qun-Zheng Wu, Xiang Zhang, Ming-Wei Zhong, Shao-Zhuang Liu, Guang-Yong Zhang, San-Yuan Hu
Bile acids (BAs), which are synthesized in the liver and cycled in the enterohepatic circulation, have been recognized as signaling molecules by activating their receptors in the intestine and liver. Serum taurine-conjugated BAs have been shown to be elevated after bariatric surgeries, although the postoperative BA profiles within the enterohepatic circulation have not been investigated. Clarification of these profiles could help explain the mechanisms by which bariatric surgery leads to BA profile alterations and subsequent metabolic effects...
December 21, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29350916/rhombohedral-to-cubic-conversion-of-gete-via-mnte-alloying-leads-to-ultralow-thermal-conductivity-electronic-band-convergence-and-high-thermoelectric-performance
#3
Zheng Zheng, Xianli Su, Rigui Deng, Constantinos C Stoumpos, Hongyao Xie, Wei Liu, Yonggao Yan, Shiqiang Hao, Ctirad Uher, Chris Wolverton, Mercouri G Kanatzidis, Xinfeng Tang
In this study, a series of Ge1-xMnxTe (x=0-0.21) compounds were prepared by melting-quenching-annealing process combined with Spark Plasma Sintering (SPS). The effect of alloying MnTe into GeTe on the structure and thermoelectric properties of Ge1-xMnxTe is profound. With increasing content of MnTe, the structure of the Ge1-xMnxTe compounds gradually changes from rhombohedral to cubic, and the known R3m to Fm-3m phase transition temperature of GeTe moves from 700 K closer to room temperature. First-principles density functional theory calculations show that alloying MnTe into GeTe decreases the energy difference between the light and heavy valence bands in both the R3m and the Fm-3m structures, enhancing a multi-band character of the valence band edge that increases the hole carrier effective mass...
January 19, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29350133/borrelia-miyamotoi-infections-in-humans-and-ticks-northeastern-china
#4
Bao-Gui Jiang, Na Jia, Jia-Fu Jiang, Yuan-Chun Zheng, Yan-Li Chu, Rui-Ruo Jiang, Ya-Wei Wang, Hong-Bo Liu, Ran Wei, Wen-Hui Zhang, Yan Li, Xiao-Wei Xu, Jin-Ling Ye, Nan-Nan Yao, Xiao-Jing Liu, Qiu-Bo Huo, Yi Sun, Ju-Liang Song, Wei Liu, Wu-Chun Cao
We conducted an investigation of Borrelia miyamotoi infections in humans and ticks in northeastern China. Of 984 patients reporting recent tick bites, 14 (1.4%) were found to be infected with B. miyamotoi by PCR and genomic sequencing. The 14 patients had nonspecific febrile manifestations, including fever, headache, anorexia, asthenia, and arthralgia. Rash, eschar, and regional lymphadenopathy were each observed in 1 patient. Four (28.6%) patients were hospitalized because of severe disease. B. miyamotoi was detected in 3...
February 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29350056/new-isolates-from-leaves-of-nicotiana-tabacum-and-their-biological-activities
#5
Shanzhai Shang, Jianlian Shi, Jianguo Tang, Juxing Jiang, Wei Zhao, Xudong Zheng, Ping Lei, Jingmei Han, Chengya Wang, Dalin Yuan, Guangyu Yang, Yongkuan Chen, Mingming Miao
Three new isolates (1-3) including one new sterol and two new flavonoids together with three known sterols (4-6) were isolated from the leaves of Nicotiana tabacum. Their structures were determined mainly by spectroscopic methods, including extensive 1D and 2D NMR techniques. All compounds were evaluated for their anti-tobacco mosaic virus and cytotoxic activities. The results showed that compounds 2 and 3 exhibited high anti-TMV activity with inhibition rate of 34.2 and 33.4%, respectively, which were roughly equivalent to that of positive control...
January 19, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29349988/-comparison-of-analgesic-effects-between-multimodal-and-patient-controlled-intravenous-analgesia-in-patients-with-rheumatoid-arthritis-in-the-perioperative-period-of-total-knee-arthroplasty
#6
Hua-Li Gao, Lian-Bo Xiao, Wei-Tao Zhai, Yong He, Fei Zhu, Lin Zheng, Xiu-Wei Han
OBJECTIVE: To compare the analgesic effect between multimodal and patient-controlled intravenous analgesia(PCIA) in patients with rheumatoid arthritis(RA) in the perioperative period of knee joint replacement. METHODS: From June 2015 to June 2016, 40 RA patients undergoing total knee arthroplasty were randomly divided into two groups. There were 20 patients in PCIA group, including 3 males and 17 females, with an average age of(59.6±2.3) years old, who received controlled instillation of sufentanil analgesia controlled by an intravenous analgesia pump...
April 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349960/-anterolateral-acromial-approach-for-the-treatment-of-proximal-humerus-in-2-or-3-part-fractures-a-case-control-study
#7
Zheng-Xin Song, Yan Liu, Ying-Fu Mao, Bing-Yan Li, Li-Jin Wei, Yun Tian
OBJECTIVE: To explore the clinical curative effect of anterolateral acromial approach in treating two-and three-part of proximal humeral fractures. METHODS: Forty-two patients of proximal humeral fractures from January 2010 to June 2014 were analyzed retrospectively, including 23 males and 19 females with a mean age of 61.5 years old ranging from 40 to 76 years old. Among them, 22 cases were treated with anterolateral acromial approach and 20 cases were treated with deltopectoral approach...
March 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349858/efficient-hysteresis-free-and-stable-perovskite-solar-cells-with-zno-as-electron-transport-layer-effect-of-surface-passivation
#8
Jing Cao, Binghui Wu, Ruihao Chen, Youyunqi Wu, Yong Hui, Bing-Wei Mao, Nanfeng Zheng
The power conversion efficiency of perovskite solar cells (PSCs) has ascended from 3.8% to 22.1% in recent years. ZnO has been well-documented as an excellent electron-transport material. However, the poor chemical compatibility between ZnO and organo-metal halide perovskite makes it highly challenging to obtain highly efficient and stable PSCs using ZnO as the electron-transport layer. It is demonstrated in this work that the surface passivation of ZnO by a thin layer of MgO and protonated ethanolamine (EA) readily makes ZnO as a very promising electron-transporting material for creating hysteresis-free, efficient, and stable PSCs...
January 19, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29349636/effects-of-asymmetric-local-joule-heating-on-silicon-nanowire-based-devices-formed-by-dielectrophoresis-alignment-across-pt-electrodes
#9
Hsiang-Hsi Ho, Chun-Lung Lin, Wei-Che Tsai, Liang-Zheng Hong, Cheng-Han Lyu, Hsun-Feng Hsu
We demonstrate the fabrication and characterization of silicon nanowire-based devices in metal-nanowire-metal configuration using direct current dielectrophoresis. The current-voltage characteristics of the devices were found rectifying, and their direction of rectification could be determined by voltage sweep direction due to the asymmetric Joule heating effect that occurred in the electrical measurement process. The photosensing properties of the rectifying devices were investigated. It reveals that when the rectifying device was in reverse-biased mode, the excellent photoresponse was achieved due to the strong built-in electric field at the junction interface...
January 16, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29348901/prevalence-and-risk-factors-of-lower-urinary-tract-symptoms-in-chinese-adult-men-a-multicentre-cross-sectional-study
#10
Meng Rao, Huangfang Shangguan, Zhengyan Zeng, Yi Zheng, Huiping Zhang, Honggang Li, Wei Xia, Changhong Zhu, Chengliang Xiong, Huangtao Guan
There has been no previous population-based study reporting the prevalence and risk factors of male lower urinary tract symptoms (LUTS) among men in mainland China. This cross-sectional study was conducted from 2013 to 2014 in three representative provinces of China: Guangdong, Hubei and Jiangsu. 3250 individuals participated in the interviews, which involved a questionnaire covering sociodemographic characteristics, lifestyle, dietary patterns and the International Prostate Symptom Score (IPSS). Blood was collected for lipids, glucose, insulin and reproductive hormone tests...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29348628/fezf1-as1-mir-107-znf312b-axis-facilitates-progression-and-warburg-effect-in-pancreatic-ductal-adenocarcinoma
#11
Huilin Ye, Quanbo Zhou, Shangyou Zheng, Guolin Li, Qing Lin, Liangtao Ye, Yingxue Wang, Lusheng Wei, Xiaohui Zhao, Wenzhu Li, Zhiqiang Fu, Yimin Liu, Zhihua Li, Rufu Chen
Long non-coding RNAs (lncRNAs) play a pivotal role in pathological processes. However, little information has been published regarding the underlying functions and mechanisms of lncRNAs in pancreatic ductal adenocarcinoma (PDAC). A novel lncRNA FEZF1-AS1 and its sense-cognate gene ZNF312B were found to be highly expressed in human PDAC tissues and cell lines, which is associated with disease progression and predicts clinical outcome in PDAC patients. Of note, bioinformatics analysis, luciferase assays and RNA immunoprecipitation assays indicated that FEZF1-AS1 may act as an endogenous sponge by competing for miR-107, thereby modulating the derepression of ZNF312B...
January 18, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29348487/h1-phgfk1-nanoparticles-exert-anti-tumoural-and-radiosensitising-effects-by-inhibition-of-met-in-glioblastoma
#12
Wenyan Zhang, Rui Duan, Jian Zhang, William K C Cheung, Xiaoge Gao, Raymond Zhang, Qing Zhang, Mengxue Wei, Gang Wang, Qian Zhang, Peng-Jin Mei, Hong-Lin Chen, Hsiangfu Kung, Marie C Lin, Zan Shen, Junnian Zheng, Longzhen Zhang, Hong Yao
BACKGROUND: The therapeutic resistance to ionising radiation (IR) and anti-angiogenesis mainly impair the prognosis of patients with glioblastoma. The primary and secondary MET aberrant activation is one crucial factor for these resistances. The kringle 1 domain of hepatocyte growth factor (HGFK1), an angiogenic inhibitor, contains a high-affinity binding domain of MET; however, its effects on glioblastoma remain elusive. METHODS: We formed the nanoparticles consisting of a folate receptor-targeted nanoparticle-mediated HGFK1 gene (H1/pHGFK1) and studied its anti-tumoural and radiosensitive activities in both subcutaneous and orthotopic human glioma cell-xenografted mouse models...
January 18, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29347909/identification-of-minor-effect-qtls-for-plant-architecture-related-traits-using-super-high-density-genotyping-and-large-recombinant-inbred-population-in-maize-zea-mays
#13
Baobao Wang, Han Liu, Zhipeng Liu, Xiaomei Dong, Jinjie Guo, Wei Li, Jing Chen, Chi Gao, Yanbin Zhu, Xinmei Zheng, Zongliang Chen, Jian Chen, Weibin Song, Andrew Hauck, Jinsheng Lai
BACKGROUND: Plant Architecture Related Traits (PATs) are of great importance for maize breeding, and mainly controlled by minor effect quantitative trait loci (QTLs). However, cloning or even fine-mapping of minor effect QTLs is very difficult in maize. Theoretically, large population and high density genetic map can be helpful for increasing QTL mapping resolution and accuracy, but such a possibility have not been actually tested. RESULTS: Here, we employed a genotyping-by-sequencing (GBS) strategy to construct a linkage map with 16,769 marker bins for 1021 recombinant inbred lines (RILs)...
January 18, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29347830/an-omic-biomarker-detection-algorithm-trivote-and-its-application-in-methylomic-biomarker-detection
#14
Cheng Xu, Jiamei Liu, Weifeng Yang, Yayun Shu, Zhipeng Wei, Weiwei Zheng, Xin Feng, Fengfeng Zhou
AIM: Transcriptomic and methylomic patterns represent two major OMIC data sources impacted by both inheritable genetic information and environmental factors, and have been widely used as disease diagnosis and prognosis biomarkers. MATERIALS & METHODS: Modern transcriptomic and methylomic profiling technologies detect the status of tens of thousands or even millions of probing residues in the human genome, and introduce a major computational challenge for the existing feature selection algorithms...
January 19, 2018: Epigenomics
https://www.readbyqxmd.com/read/29346835/two-citrate-transporters-coordinately-regulate-citrate-secretion-from-rice-bean-root-tip-under-aluminum-stress
#15
Mei Ya Liu, He Qiang Lou, Wei Wei Chen, Miguel A Piñeros, Jia Meng Xu, Wei Fan, Leon V Kochian, Shao Jian Zheng, Jian Li Yang
Al-induced organic acid secretion from the root apex is an important Al resistance mechanism. However, it remains unclear how plants fine-tune root organic acid secretion which can contribute significantly to the loss of fixed carbon from the plant. Here, we demonstrate that Al-induced citrate secretion from the rice bean root apex is biphasic, consisting of an early phase with low secretion and a later phase of large citrate secretion. We isolated and characterized VuMATE2 as a possible second citrate transporter in rice bean functioning in tandem with VuMATE1, which we previously identified...
January 18, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29346779/predictors-of-recoverability-of-renal-function-after-pyeloplasty-in-adults-with-ureteropelvic-junction-obstruction
#16
Xiao-Dong Li, Yu-Peng Wu, Yong Wei, Shao-Hao Chen, Qing-Shui Zheng, Hai Cai, Xue-Yi Xue, Ning Xu
BACKGROUND: This study aimed to identify factors predicting the recoverability of renal function after pyeloplasty in adult patients with ureteropelvic junction obstruction. METHODS: We retrospectively reviewed 138 adults with unilateral renal obstruction-induced hydronephrosis and who underwent Anderson-Hynes dismembered pyeloplasty from January 2013 to January 2016. Hydronephrosis was classified preoperatively according to the Society for Fetal Urology (SFU) grading system...
January 18, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29346752/epitranscriptomic-m6a-regulation-of-axon-regeneration-in-the-adult-mammalian-nervous-system
#17
Yi-Lan Weng, Xu Wang, Ran An, Jessica Cassin, Caroline Vissers, Yuanyuan Liu, Yajing Liu, Tianlei Xu, Xinyuan Wang, Samuel Zheng Hao Wong, Jessica Joseph, Louis C Dore, Qiang Dong, Wei Zheng, Peng Jin, Hao Wu, Bin Shen, Xiaoxi Zhuang, Chuan He, Kai Liu, Hongjun Song, Guo-Li Ming
N6-methyladenosine (m6A) affects multiple aspects of mRNA metabolism and regulates developmental transitions by promoting mRNA decay. Little is known about the role of m6A in the adult mammalian nervous system. Here we report that sciatic nerve lesion elevates levels of m6A-tagged transcripts encoding many regeneration-associated genes and protein translation machinery components in the adult mouse dorsal root ganglion (DRG). Single-base resolution m6A-CLIP mapping further reveals a dynamic m6A landscape in the adult DRG upon injury...
January 17, 2018: Neuron
https://www.readbyqxmd.com/read/29346561/floricolin-c-elicits-intracellular-ros-accumulation-and-disrupts-mitochondria-to-exert-fungicidal-action
#18
Ming Zhang, Wenqiang Chang, Hongzhuo Shi, Ying Li, Sha Zheng, Wei Li, Hongxiang Lou
Candida albicans, one most prevalent fungal pathogen, causes severe mucosal and invasive infections in predisposed individuals. The rise of fungal infection and drug-resistance demands the development of novel antifungal agents. In this study, we observed that floricolin C (FC), a p-terphenyl pigment from an endolichenic fungus, killed C. albicans cells at planktonic state or within biofilms through reactive oxygen species (ROS) accumulation. Further test revealed that FC could directly damage the mitochondria to cause ROS accumulation...
January 15, 2018: FEMS Yeast Research
https://www.readbyqxmd.com/read/29345917/anisotropic-assembly-of-ag52-and-ag76-nanoclusters
#19
Jia-Wei Liu, Lei Feng, Haifeng Su, Zhi Wang, Quan-Qin Zhao, Xingpo Wang, Chen-Ho Tung, Di Sun, Lan-Sun Zheng
Although there has been an upsurge of interest in anisotropic assembly of inorganic nanoparticles, atomically precise self-assembly of anisotropic (nonspherical) high-nuclearity metal clusters is extremely rare. Herein, we presented two novel silver nanoclusters, Ag52 (SD/Ag23) and Ag76 (SD/Ag24), which are interiorly templated by five MoO42- and a pair of Mo6O228- anions, respectively, and co-protected by bridging RSH and terminal diphosphine ligands exteriorly. Regiospe-cific distribution diphosphine ligands on the surface and the arrangement of multiple molybdate templates within the nanoclusters synergetically tailor their shapes to anisotropic oblate spheroid and elongated rod, respectively, as opposed to isotropic nanospheres...
January 18, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29344667/clinical-evaluation-of-covered-stents-in-the-treatment-of-superficial-femoral-artery-pseudoaneurysm-in-drug-abusers
#20
Jian Xu, Zhao Zheng, Yong Yang, Wei Zhang, Hongliang Zhao, Bei E, Minwen Zheng
The present study aimed to investigate the technical feasibility and initial clinical outcomes of a covered stent for the endovascular treatment of superficial femoral artery (SFA) pseudoaneurysm in drug abusers. A total of 29 drug abuse patients with SFA pseudoaneurysm, as confirmed by color Doppler sonography, were enrolled to the present study between January 2012 and May 2014. All patients were treated percutaneously by implantation of a covered stent. Physical examination and lower extremity computed tomography angiography were performed at 1 and 9 months postoperation...
January 15, 2018: Molecular Medicine Reports
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