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https://www.readbyqxmd.com/read/28917792/zno-nanotubes-supported-molecularly-imprinted-polymers-arrays-as-sensing-materials-for-electrochemical-detection-of-dopamine
#1
Hai-Hui Wang, Xuan-Jie Chen, Wei-Tian Li, Wen-Hui Zhou, Xiu-Chun Guo, Wen-Yi Kang, Dong-Xing Kou, Zheng-Ji Zhou, Yue-Na Meng, Qing-Wen Tian, Si-Xin Wu
In this study, ZnO nanotubes (ZNTs) were prepared onto fluorine-doped tin oxide (FTO) glass and used as supports for MIPs arrays fabrication. Due to the imprinted cavities are always located at both inner and outer surface of ZNTs, these ZNTs supported MIPs arrays have good accessibility towards template and can be used as sensing materials for chemical sensors with high sensitivity, excellent selectivity and fast response. Using K3[Fe(CN)6] as electron probe, the fabricated electrochemical sensor shows two linear dynamic ranges (0...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28917767/hierarchical-oxygen-implanted-mos2-nanoparticle-decorated-graphene-for-the-non-enzymatic-electrochemical-sensing-of-hydrogen-peroxide-in-alkaline-media
#2
Yudong Xue, Govindhan Maduraiveeran, Mingyong Wang, Shili Zheng, Yi Zhang, Wei Jin
Owing to the extensive applications of hydrogen peroxide (H2O2) in biological, environmental and chemical engineering, it is of great importance to investigate sensitive and selective sensing platform towards the detection of H2O2. Herein, oxygen-implanted MoS2 nanoparticles decorated graphene nanocomposite is synthesized via a facile one-pot solvothermal method for the sensitive detection of H2O2 in alkaline media. The structure and morphology of the MoS2/graphene nanocomposites were systematically characterized, showing that Mo-O bonds are formed and oxygen is implanted into the crystal structure in the nanocomposite...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28916893/safety-and-prognostic-impact-of-prophylactic-laparoscopic-superior-mesenteric-vein-no-14v-lymph-node-dissection-for-lower-third-gastric-cancer-a-propensity-score-matched-case-control-study
#3
Qi-Yue Chen, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ju-Li Lin, Chang-Ming Huang
AIM: To investigate oncologic efficacy of prophylactic laparoscopic superior mesenteric vein (No. 14v) lymph node (LN) dissection for lower-third gastric cancer (LTGC). METHODS: We retrospectively collected data from 757 patients who underwent laparoscopic-assisted distal gastrectomy for LTGC. Of these patients, 102 underwent 14v LN dissection (14vD+ group), and the remaining 655 patients did not undergo 14v LN dissection (14vD- group). The outcomes were compared using a 1:1 propensity score matching method...
September 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28916818/identification-of-4-phenylquinolin-2-1h-one-as-a-specific-allosteric-inhibitor-of-akt
#4
Bill X Huang, Kenny Newcomer, Karl Kevala, Elena Barnaeva, Wei Zheng, Xin Hu, Samarjit Patnaik, Noel Southall, Juan Marugan, Marc Ferrer, Hee-Yong Kim
Akt plays a major role in tumorigenesis and the development of specific Akt inhibitors as effective cancer therapeutics has been challenging. Here, we report the identification of a highly specific allosteric inhibitor of Akt through a FRET-based high-throughput screening, and characterization of its inhibitory mechanism. Out of 373,868 compounds screened, 4-phenylquinolin-2(1H)-one specifically decreased Akt phosphorylation at both T308 and S473, and inhibited Akt kinase activity (IC50 = 6 µM) and downstream signaling...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28915891/inflammatory-bowel-disease-specific-health-related-quality-of-life-instruments-a-systematic-review-of-measurement-properties
#5
REVIEW
Xin-Lin Chen, Liang-Huan Zhong, Yi Wen, Tian-Wen Liu, Xiao-Ying Li, Zheng-Kun Hou, Yue Hu, Chuan-Wei Mo, Feng-Bin Liu
BACKGROUND: This review aims to critically appraise and compare the measurement properties of inflammatory bowel disease (IBD)-specific health-related quality of life instruments. METHODS: Medline, EMBASE and ISI Web of Knowledge were searched from their inception to May 2016. IBD-specific instruments for patients with Crohn's disease, ulcerative colitis or IBD were enrolled. The basic characteristics and domains of the instruments were collected. The methodological quality of measurement properties and measurement properties of the instruments were assessed...
September 15, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28915826/acupuncture-lowering-blood-pressure-for-secondary-prevention-of-stroke-a-study-protocol-for-a-multicenter-randomized-controlled-trial
#6
Yu-Zheng Du, Xin-Xin Gao, Cheng-Ting Wang, Hai-Zhen Zheng, Yun Lei, Meng-Han Wu, Xue-Min Shi, Hai-Peng Ban, Wen-Long Gu, Xiang-Gang Meng, Mao-Ti Wei, Chun-Xiao Hu
BACKGROUND: Stroke is the prime cause of morbidity and mortality in the general population, and hypertension will increase the recurrence and mortality of stroke. We report a protocol of a pragmatic randomized controlled trial (RCT) using blood pressure (BP)-lowering acupuncture add-on treatment to treat patients with hypertension and stroke. METHODS: This is a large-scale, multicenter, subject-, assessor- and analyst-blinded, pragmatic RCT. A total of 480 patients with hypertension and ischemic stroke will be randomly assigned to two groups: an experimental group and a control group...
September 15, 2017: Trials
https://www.readbyqxmd.com/read/28915689/different-long-term-oncologic-outcomes-after-radical-surgical-resection-for-neuroendocrine-carcinoma-and-adenocarcinoma-of-the-stomach
#7
Jian-Wei Xie, Jun Lu, Jian-Xian Lin, Chao-Hui Zheng, Ping Li, Jia-Bin Wang, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chang-Ming Huang
PURPOSE: To explore differences in long-term outcomes between gastric neuroendocrine carcinoma (GNEC) and gastric adenocarcinoma (GAC). METHODS: One hundred GNEC patients and 3089 GAC patients were enrolled. Differences in long-term outcomes between the groups were analyzed by 1:2 propensity score matching. RESULTS: Statistically significant differences between the groups were noted in terms of gender, American Society of Anesthesiologists score, tumor size, T stage, N stage, TNM stage and surgical approach...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915651/programmed-differentiated-natural-killer-cells-kill-leukemia-cells-by-engaging-slam-family-receptors
#8
Yang Wu, Young Li, Binqing Fu, Linlin Jin, Xiaohu Zheng, Aimei Zhang, Rui Sun, Zhigang Tian, Haiming Wei
Natural killer (NK) cells are important innate immune cells that can directly kill transformed or virus-infected cells. The adoptive transfer of NK cells has been used to treat hematological malignancies; however, the limited sources and quantities of NK cells have restricted their clinical application. Here, we acquired sufficient quantities of functional NK cells from CD34(+) cells treated with a cytokine cocktail. Microarray analysis of the cultured cells revealed a two-stage pattern of programmed differentiation during NK cell development...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915624/microwave-ablation-combined-with-egfr-tkis-versus-only-egfr-tkis-in-advanced-nsclc-patients-with-egfr-sensitive-mutations
#9
Zhigang Wei, Xin Ye, Xia Yang, Aimin Zheng, Guanghui Huang, Wenhong Li, Jiao Wang, Xiaoying Han, Min Meng, Yang Ni
We conducted this retrospective study to investigate whether microwave ablation (MWA) of primary tumor sites plus epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) could improve survival in advanced non small cell lung cancer (NSCLC) with EGFR mutations. MWA was conducted at the primary tumor sites, followed by EGFR-TKIs in the MWA plus EGFR-TKIs group. EGFR-TKIs were administered until disease progression or intolerable toxicity. The primary endpoint was progression-free survival (PFS); secondary endpoints were overall survival (OS) and objective response rate (ORR)...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28914046/synergistic-effect-of-polypyrrole-intercalated-graphene-for-enhanced-corrosion-protection-of-aqueous-coating-in-3-5-nacl-solution
#10
Shihui Qiu, Wei Li, Wenru Zheng, Haichao Zhao, Liping Wang
Dispersion of graphene in water and incorporation of it into waterborne resin have been rarely researched and hardly achieved owing to its hydrophobicity. Furthermore, it has largely been reported that graphene with impermeability contributed to the improved anticorrosion property. Here we show that highly concentrated graphene aqueous solution up to 5 mg/mL can be obtained by synthesizing hydrophilic polypyrrole nanocolloids as intercalators and ultrasonic vibration. Based on the π-π interaction between polypyrrole and graphene, stacked graphene sheets are exfoliated to the thickness of 3~5 layers without increasing defects...
September 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28913982/validation-of-the-american-joint-commission-on-cancer-8th-edition-changes-for-patients-with-stage-iii-gastric-cancer-survival-analysis-of-a-large-series-from-a-specialized-eastern-center
#11
Jun Lu, Chao-Hui Zheng, Long-Long Cao, Shao-Wei Ling, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Mi Lin, Ru-Hong Tu, Chang-Ming Huang
The 8th edition of the TNM was released in 2016 and included major revisions, especially for stage III. We aimed to compare the prognostic value of the 7th and 8th editions of the AJCC TNM classification for stage III gastric cancer. Clinical data from 1557 patients operated on for stage III gastric cancer according to the 7th edition between 2007 and 2014 were analyzed and compared using the 7th and 8th TNM classifications. A proposed staging system was established, and the three systems were compared in terms of prognostic performance...
September 14, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28912892/real-time-in-vivo-diagnosis-of-nasopharyngeal-carcinoma-using-rapid-fiber-optic-raman-spectroscopy
#12
Kan Lin, Wei Zheng, Chwee Ming Lim, Zhiwei Huang
We report the utility of a simultaneous fingerprint (FP) (i.e., 800-1800 cm(-1)) and high-wavenumber (HW) (i.e., 2800-3600 cm(-1)) fiber-optic Raman spectroscopy developed for real-time in vivo diagnosis of nasopharyngeal carcinoma (NPC) at endoscopy. A total of 3731 high-quality in vivo FP/HW Raman spectra (normal=1765; cancer=1966) were acquired in real-time from 204 tissue sites (normal=95; cancer=109) of 95 subjects (normal=57; cancer=38) undergoing endoscopic examination. FP/HW Raman spectra differ significantly between normal and cancerous nasopharyngeal tissues that could be attributed to changes of proteins, lipids, nucleic acids, and the bound water content in NPC...
2017: Theranostics
https://www.readbyqxmd.com/read/28912857/overexpression-of-transcription-factor-activating-enhancer-binding-protein-4-tfap4-predicts-poor-prognosis-for-colorectal-cancer-patients
#13
Jianchang Wei, Ping Yang, Tong Zhang, Zhuanpeng Chen, Wei Chen, Li Wanglin, Feng He, Fang Wei, Di Huang, Junbin Zhong, Zhi Yang, Huacui Chen, He Hu, Shanqi Zeng, Zheng Sun, Jie Cao
Transcription factor activating enhancer binding protein 4 (TFAP4) is an important regulator in the genesis and progression of human cancers. Overexpression of TFAP4 has been found to be correlated with several malignancies. The present study assessed the clinical importance of TFAP4 in colorectal cancer (CRC). First, immunohistochemistry was used to analyze TFAP4 expression and the association of TFAP4 expression with clinicopathological features on a tissue microarray containing 208 CRC patients. The results revealed that TFAP4 protein expression was significantly upregulated in CRC tissues compared with that in normal colon tissues (P<0...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28912701/spectral-entropy-can-predict-changes-of-working-memory-performance-reduced-by-short-time-training-in-the-delayed-match-to-sample-task
#14
Yin Tian, Huiling Zhang, Wei Xu, Haiyong Zhang, Li Yang, Shuxing Zheng, Yupan Shi
Spectral entropy, which was generated by applying the Shannon entropy concept to the power distribution of the Fourier-transformed electroencephalograph (EEG), was utilized to measure the uniformity of power spectral density underlying EEG when subjects performed the working memory tasks twice, i.e., before and after training. According to Signed Residual Time (SRT) scores based on response speed and accuracy trade-off, 20 subjects were divided into two groups, namely high-performance and low-performance groups, to undertake working memory (WM) tasks...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28911103/prediction-of-genome-wide-dna-methylation-in-repetitive-elements
#15
Yinan Zheng, Brian T Joyce, Lei Liu, Zhou Zhang, Warren A Kibbe, Wei Zhang, Lifang Hou
DNA methylation in repetitive elements (RE) suppresses their mobility and maintains genomic stability, and decreases in it are frequently observed in tumor and/or surrogate tissues. Averaging methylation across RE in genome is widely used to quantify global methylation. However, methylation may vary in specific RE and play diverse roles in disease development, thus averaging methylation across RE may lose significant biological information. The ambiguous mapping of short reads by and high cost of current bisulfite sequencing platforms make them impractical for quantifying locus-specific RE methylation...
September 6, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28910770/global-local-temporal-saliency-action-prediction
#16
Shaofan Lai, Wei-Shi Zheng, Jian-Fang Hu, Jianguo Zhang
Action prediction on a partially observed action sequence is a very challenging task. To address this challenge, we first design a global-local distance model, where a global-temporal distance compares subsequences as a whole and local-temporal distance focuses on individual segment. Our distance model introduces temporal saliency for each segment to adapt its contribution. Finally, a global-local temporal action prediction model is formulated in order to jointly learn and fuse these two types of distances...
September 11, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28910431/hla-mismatched-microtransplant-in-older-patients-newly-diagnosed-with-acute-myeloid-leukemia-results-from-the-microtransplantation-interest-group
#17
Mei Guo, Nelson J Chao, Jian-Yong Li, David A Rizzieri, Qi-Yun Sun, Ann Mohrbacher, Elizabeth F Krakow, Wan-Jun Sun, Xu-Liang Shen, Xin-Rong Zhan, De-Pei Wu, Li Liu, Juan Wang, Min Zhou, Lin-Hua Yang, Yang-Yi Bao, Zheng Dong, Bo Cai, Kai-Xun Hu, Chang-Lin Yu, Jian-Hui Qiao, Hong-Li Zuo, Ya-Jing Huang, Anthony D Sung, Jun-Xiao Qiao, Zhi-Qing Liu, Tie-Qiang Liu, Bo Yao, Hong-Xia Zhao, Si-Xuan Qian, Wei-Wei Liu, Rafael Forés, Rafael F Duarte, Hui-Sheng Ai
Importance: The outcome of older patients with acute myeloid leukemia (AML) remains unsatisfactory. Recent studies have shown that HLA-mismatched microtransplant could improve outcomes in such patients. Objective: To evaluate outcomes in different age groups among older patients with newly diagnosed AML who receive HLA-mismatched microtransplant. Design, Setting, and Participants: This multicenter clinical study included 185 patients with de novo AML at 12 centers in China, the United States, and Spain in the Microtransplantation Interest Group...
September 14, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28906385/percutaneous-intratumoral-injection-of-gemcitabine-plus-cisplatin-mixed-with-fibrin-glue-for-advanced-pancreatic-carcinoma-case-report
#18
Biao Yang, Jian-Ping He, Min-Lan Yuan, Wei Li, He Jiao, Xin You, Xing-Rong Liu, Jian Zhao, Chun-Lin Li, Xiao-Bo Fu, Zheng-Yin Liao, Cheng Yi
RATIONALE: The aim of this study was to determine the effectiveness of intratumoral injection of chemotherapeutics in improving the quality of life and survival of patients with pancreatic carcinoma. PATIENT CONCERNS: We present a case series of 5 patients with unresectable pancreatic adenocarcinoma. DIAGNOSES: Patients diagnosed with unresectable poorly differentiated pancreatic ductal adenocarcinoma by intraoperative frozen biopsyor percutaneous biopsy...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28906032/from-anilines-to-quinolines-iodide-and-silver-mediated-aerobic-c-h-c-h-oxidative-annulation-aromatization
#19
Jiwei Wu, Zhixiong Liao, Dong Liu, Chien-Wei Chiang, Zheng Li, Zhonghao Zhou, Hong Yi, Xu Zhang, Zixin Deng, Aiwen Lei
Quinolines synthesis from easily accessible raw materials, such as anilines, is valuable and meaningful task. Herein, we communicate an iodide and silver-mediated C-H/C-H oxidative annulation/aromatization between anilines and allyl alcohols. This protocol provides a direct route to the synthesis of quinolines derivatives f rom inexpensive commodit ies. Various kinds of anilines, even heterocyclic anilines, were shown to be workable substrates, generating the corresponding multi-substituted quinolines in good yields...
September 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28904507/adjunctive-melatonin-for-tardive-dyskinesia-in-patients-with-schizophrenia-a-meta-analysis
#20
Chen-Hui Sun, Wei Zheng, Xin-Hu Yang, Dong-Bin Cai, Chee H Ng, Gabor S Ungvari, Hai-Yan Li, Yu-Jie Wu, Yu-Ping Ning, Yu-Tao Xiang
BACKGROUND: Tardive dyskinesia (TD) is characterized by abnormal and involuntary movements. Importantly, TD could cause considerable personal suffering and social and physical disabilities. AIMS: This meta-analysis based on randomized controlled trials (RCTs) systematically assessed the therapeutic effect and tolerability of melatonin for TD in schizophrenia. METHODS: A computerized and systematical search of both Chinese (Wanfang Data, Chinese National Knowledge Infrastructure (CNKI), SINOMED) and English (PubMed, PsycINFO, Embase, Cochrane Library databases) databases, from their inception until June 8, 2017, was conducted by two independent authors...
June 25, 2017: Shanghai Archives of Psychiatry
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