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https://www.readbyqxmd.com/read/29679306/regenerative-medicine-strategies-in-biomedical-implants
#1
REVIEW
Divya Rani Bijukumar, Clay McGeehan, Mathew T Mathew
PURPOSE OF REVIEW: Recently, significant progress has been made in the research related to regenerative medicine. At the same time, biomedical implants in orthopedics and dentistry are facing many challenges and posing clinical concerns. The purpose of this chapter is to provide an overview of the clinical applications of current regenerative strategies to the fields of dentistry and orthopedic surgery. The main research question in this review is: What are the major advancement strategies in regenerative medicine that can be used for implant research? RECENT FINDINGS: The implant surfaces can be modified through patient-specific stem cells and plasma coatings, which may provide methods to improve osseointegration and sustainability of the implant...
April 20, 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29677629/effects-of-gastric-bypass-surgery-followed-by-supervised-physical-training-on-inflammation-and-endothelial-function-a-randomized-controlled-trial
#2
Charlotte Røn Stolberg, Lene Hymøller Mundbjerg, Peter Funch-Jensen, Bibi Gram, Else-Marie Bladbjerg, Claus Bogh Juhl
BACKGROUND AND AIMS: Obesity and physical inactivity are both associated with low-grade inflammation and endothelial dysfunction. Bariatric surgery improves markers of inflammation and endothelial function, but it is unknown if physical training after bariatric surgery can improve these markers even further. Therefore, we aimed to investigate the effects of Roux-en-Y gastric bypass (RYGB) followed by physical training on markers of low-grade inflammation and endothelial function. METHODS: Sixty patients approved for RYGB underwent examinations pre-surgery, 6, 12, and 24 months post-surgery...
April 6, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29677032/landiolol-hydrochloride-rapidly-controls-junctional-ectopic-tachycardia-after-pediatric-heart-surgery
#3
Fumiya Yoneyama, Chiho Tokunaga, Hideyuki Kato, Tomomi Nakajima, Bryan J Mathis, Hiroaki Sakamoto, Yuji Hiramatsu
OBJECTIVES: Junctional ectopic tachycardia is a supraventricular tachyarrhythmia with atrioventricular dissociation that causes life-threatening postsurgical conditions in pediatric heart patients. This study evaluates the efficacy of landiolol hydrochloride for managing junctional ectopic tachycardia. DESIGN: A single-center retrospective study. SETTING: PICU at the university hospital. PATIENTS: Of 561 pediatric patients who underwent open-heart surgery between 2006 and 2017, 10 patients developed sustained junctional ectopic tachycardia and were selected for landiolol treatment...
April 19, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29674451/fully-reduced-hmgb1-accelerates-the-regeneration-of-multiple-tissues-by-transitioning-stem-cells-to-g-alert
#4
Geoffrey Lee, Ana Isabel Espirito Santo, Stefan Zwingenberger, Lawrence Cai, Thomas Vogl, Marc Feldmann, Nicole J Horwood, James K Chan, Jagdeep Nanchahal
A major discovery of recent decades has been the existence of stem cells and their potential to repair many, if not most, tissues. With the aging population, many attempts have been made to use exogenous stem cells to promote tissue repair, so far with limited success. An alternative approach, which may be more effective and far less costly, is to promote tissue regeneration by targeting endogenous stem cells. However, ways of enhancing endogenous stem cell function remain poorly defined. Injury leads to the release of danger signals which are known to modulate the immune response, but their role in stem cell-mediated repair in vivo remains to be clarified...
April 19, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29673908/mechanism-underlying-the-contractile-activity-of-utp-in-the-mammalian-heart
#5
Ulrich Gergs, Daniel Rothkirch, Britt Hofmann, Hendrik Treede, Bernard Robaye, Andreas Simm, Christa E Müller, Joachim Neumann
We previously reported that uridine 5'-triphosphate (UTP), a pyrimidine nucleoside triphosphate produced a concentration- and time-dependent increase in the contraction force in isolated right atrial preparations from patients undergoing cardiac bypass surgery due to angina pectoris. The stimulation of the force of contraction was sustained rather than transient. In the present study, we tried to elucidate the underlying receptor and signal transduction for this effect of UTP. Therefore, we measured the effect of UTP on force of contraction, phosphorylation of p38 and ERK1/2, in human atrial preparations, atrial preparations from genetically modified mice, cardiomyocytes from adult mice and cardiomyocytes from neonatal rats...
April 16, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29670790/use-of-the-pelvic-c-clamp-to-mitigate-acute-respiratory-distress-syndrome-in-a-patient-with-an-unstable-sacral-fracture
#6
Michael J DeRogatis, Paul S Issack
Case: We present the case of a 21-year-old man who fell from a roof, sustaining a displaced sacral fracture with pelvic instability. He developed acute respiratory distress syndrome (ARDS) within 24 hours of injury. Placement of the pelvic C-clamp resulted in rapid resolution of pulmonary dysfunction, allowing for definitive internal fixation. Conclusion: The C-clamp is most commonly used to control hemorrhage in unstable posterior pelvic ring injuries. Our case demonstrates a rare use of the C-clamp to stabilize the posterior pelvis in a patient with an unstable sacral fracture and ARDS, to rapidly improve pulmonary function prior to definitive surgery...
2018: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29670622/immune-reconstitution-after-autologous-hematopoietic-stem-cell-transplantation-in-crohn-s-disease-current-status-and-future-directions-a-review-on-behalf-of-the-ebmt-autoimmune-diseases-working-party-and-the-autologous-stem-cell-transplantation-in-refractory
#7
REVIEW
Alan Graham Pockley, James O Lindsay, Gemma A Foulds, Sergio Rutella, John G Gribben, Tobias Alexander, John A Snowden
Patients with treatment refractory Crohn's disease (CD) suffer debilitating symptoms, poor quality of life, and reduced work productivity. Surgery to resect inflamed and fibrotic intestine may mandate creation of a stoma and is often declined by patients. Such patients continue to be exposed to medical therapy that is ineffective, often expensive and still associated with a burden of adverse effects. Over the last two decades, autologous hematopoietic stem cell transplantation (auto-HSCT) has emerged as a promising treatment option for patients with severe autoimmune diseases (ADs)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29669488/physical-activity-and-exercise-therapy-benefits-more-than-just-symptoms-and-impairments-in-people-with-hip-and-knee-osteoarthritis
#8
Søren T Skou, Bente Klarlund Pedersen, J Haxby Abbott, Brooke Patterson, Christian Barton
Synopsis Hip and knee osteoarthritis (OA) are among the leading causes of global disability, highlighting the need for early, targeted, and effective treatments. The benefits on symptoms and impairments of exercise therapy in people with hip and knee OA are substantial and supported by high-quality evidence, underlining that it should be part of first line treatment offered to all people with hip and knee OA in clinical practice. Furthermore, unlike other treatments for OA such as analgesia and surgery, exercise therapy is not associated with risk of serious harm...
April 18, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29668998/methotrexate-and-thioguanine-rescue-therapy-for-conventional-thiopurine-failing-ulcerative-colitis-patients-a-multi-center-database-study-on-tolerability-and-effectiveness
#9
Berrie Meijer, Chris J J Mulder, Gerd Bouma, Cyriel Y Ponsioen, C Janneke van der Woude, Andrea E van der Meulen, Dion S J Wintjens, Gerard Dijkstra, Frank Hoentjen, Bas Oldenburg, Adriaan A van Bodegraven, Nanne K H de Boer
Background: Patients with active ulcerative colitis (UC) failing conventional therapies are in need of rescue strategies. Due to the fact that accepted step-up therapy with biologicals is expensive and sometimes unavailable, alternative therapies are warranted. Methotrexate (MTX) and thioguanine (TG) have both been suggested as alternative maintenance strategies in conventional thiopurine failing UC patients. In this multicenter database study, we compared safety and effectiveness (drug-survival) of MTX and TG in UC patients...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29666000/how-does-the-application-of-surgical-components-in-enhanced-recovery-programs-for-colorectal-surgery-change-over-time
#10
Julie Veziant, Daniel Leonard, Bruno Pereira, Karem Slim
BACKGROUND: Enhanced recovery programs (ERP) improve post-operative outcomes in proportion to how fully they are implemented. Maintaining an optimal level of application of all the ER components is thus essential. Our aim was to assess the sustainability of ER surgical components 2 years after their first implementation. METHOD: Patients undergoing elective colorectal resections were included in a prospective database. To retrospectively analyze compliance with ERP over a period of 24 months, the following components were considered: colonic preparation, surgical approach, nasogastric tube omission and absence of abdominal drainage...
April 14, 2018: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/29660456/chitosan-based-hydrogels-preparation-properties-and-applications
#11
Zahra Shariatinia, Azin Mazloom Jalali
Chitosan (CS), the second most plentiful natural polysaccharide next to cellulose, has valuable characteristics including biocompatibility, nontoxicity and biodegradability. CS is broken down in the human body to innocuous products (amino sugars). Hydrogels are polymeric materials with three dimensional networks retaining a huge quantity of water within their structures which are of great interest in biomedical/environmental applications. Usually, injectable hydrogels have functional groups which are sensitive to pH, temperature or irradiation stimuli...
April 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29650475/use-of-patient-reported-outcome-measures-in-oral-and-maxillofacial-trauma-surgery-a-review
#12
REVIEW
R Ologunde, N M H McLeod
In the UK, about one person/100/year sustains a facial injury, so trauma surgery accounts for a considerable part of the caseload in oral and maxillofacial surgery (OMFS). Patient-reported outcome measures (PROM) allow for patient-centred assessment of postoperative outcomes, but to our knowledge, most research in OMFS trauma does not currently include them. To investigate their use, we searched Medline to find relevant studies that reported outcomes from inception in January 1879 to August 2016. Those not in the English language and those that did not report operations were excluded...
April 9, 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29644282/teriparatide-and-vertebral-fracture-healing-in-ankylosing-spondylitis
#13
Izolda Biro, Judith Bubbear, Simon Donnelly, Zozik Fattah, James Sarkodieh, Arun Ranganathan, Hasan Tahir
Patients with Ankylosing Spondylitis (AS) are four times more likely to sustain spinal fractures. Due to the associated risk of neurological complications treatment is complex. We present the case of a 56-year-old Caucasian gentleman with AS who sustained a fracture of T2 vertebra following a traumatic hyperextension injury. He declined surgery in fear of complications and started treatment with subcutaneous Teriparatide at a dose of 20 mg daily for six months. There was complete healing of the vertebral fracture at 6 months without any complications...
December 2017: Trauma Case Reports
https://www.readbyqxmd.com/read/29643557/reversal-agents-do-we-need-to-administer-with-neuromuscular-monitoring-an-observational-study
#14
Shilpa Goyal, Nikhil Kothari, Deepak Chaudhary, Shilpi Verma, Pooja Bihani, Mahaveer Singh Rodha
Background and Aims: In clinical practice, in the majority of patients, recovery from the effect of muscle relaxants is assessed using subjective methods such as head lift, eye-opening, or by sustained hand grip after giving anticholinesterases (neostigmine) at the end of surgery. We planned a prospective observational cohort study to test the hypothesis that objective neuromuscular monitoring can help us in avoiding the use of anticholinesterases for reversal. Methods: The patients posted for surgery of <2 h duration were included in the study...
March 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29629485/has-the-time-come-to-be-more-aggressive-with-bariatric-surgery-in-obese-patients-with-chronic-systolic-heart-failure
#15
REVIEW
Amanda R Vest
PURPOSE OF REVIEW: Obesity is a strong risk factor for the development of heart failure (HF). Diet, exercise, and weight-loss pharmacotherapies have limited potential to achieve significant and sustainable weight loss, especially in patients with symptomatic systolic HF. This review seeks to determine the role of bariatric surgery for patients with systolic HF and obesity. RECENT FINDINGS: Bariatric surgeries such as the laparoscopic sleeve gastrectomy (LSG) and Roux-en-Y gastric bypass (RYGB) represent the most successful long-term strategy for achieving weight loss and diabetes and hypertension remission in the general obese population...
April 8, 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29629198/patient-health-engagement-phe-model-in-enhanced-recovery-after-surgery-eras-monitoring-patients-engagement-and-psychological-resilience-in-minimally-invasive-thoracic-surgery
#16
REVIEW
Guendalina Graffigna, Serena Barello
In the last decade, the humanization of medicine has contributed to an important shift in medical paradigms (from a doctor-centered to a patient-centered approach to care). This paradigm shift promoted a greater acknowledgement of patient engagement as a crucial asset for healthcare due to its benefits on both clinical outcomes and healthcare sustainability. Particularly, patient engagement should be considered a vital parameter for the healthcare system as well as it is a marker of the patients' ability to be resilient to the illness experience and thus to be an effective manager of his/her own health after the diagnosis...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29628411/impact-of-esophageal-atresia-on-the-success-of-fundoplication-for-gastroesophageal-reflux
#17
Samantha A Pellegrino, Sebastian K King, Elizabeth McLeod, Alisa Hawley, Jo-Anne Brooks, John M Hutson, Warwick J Teague
OBJECTIVES: Fundoplication is commonly performed in patients with a history of esophageal atresia (EA), however, the success of this surgery is reduced, as reflected by an increased rate of redo fundoplication. We aimed to determine whether EA impacts the prevalence of fundoplication, its timing, and performance of a redo operation. STUDY DESIGN: A single-center, retrospective review of all patients undergoing fundoplication over a 20-year period (1994-2013) was performed...
April 5, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29627886/operation-evaluation-in-human-of-a-novel-remote-controlled-vascular-interventional-robot
#18
Xianqiang Bao, Shuxiang Guo, Nan Xiao, Youxiang Li, Cheng Yang, Rui Shen, Jinxin Cui, Yuhua Jiang, Xinke Liu, Keyun Liu
Remote-controlled vascular interventional robots (RVIRs) are being developed to increase the accuracy of surgical operations and reduce the number of occupational risks sustained by intervening physicians, such as radiation exposure and chronic neck/back pain. However, complex control of the RVIRs improves the doctor's operation difficulty and reduces the operation efficiency. Furthermore, incomplete sterilization of the RVIRs will increase the risk of infection, or even cause medical accidents. In this study, we introduced a novel method that provides higher operation efficiency than a previous prototype and allows for complete robot sterilization...
April 7, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29627180/transatrial-implantation-of-a-transcatheter-heart-valve-for-severe-mitral-annular-calcification
#19
Fabien Praz, Omar K Khalique, Raymond Lee, Ramesh Veeragandham, Hyde Russell, Mayra Guerrero, Ashequl M Islam, David W Deaton, Tsuyoshi Kaneko, Susheel K Kodali, Martin B Leon, Vinayak Bapat, Hiroo Takayama, Michael A Borger, Isaac George
OBJECTIVE: To assess the outcomes of transatrial implantation of a transcatheter heart valve (THV) for the treatment of mitral valve disease with severe mitral annular calcification (MAC). METHODS: Implantation of a balloon-expandable THV was performed on cardiopulmonary bypass via left atrial exposure in patients considered at risk for left ventricular outflow tract obstruction. The anterior mitral valve leaflet was systematically resected and pledgeted sutures were placed to enhance stability and reduce paravalvular leak...
March 12, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29626612/genicular-radiofrequency-ablation-for-the-treatment-of-post-traumatic-knee-pain-a-case-presentation
#20
Jonathan D Carrier, Michelle Poliak-Tunis
This is the first reported case presentation utilizing cooled genicular radiofrequency ablation (C-RFA) for the treatment of post-traumatic knee pain. The patient is a 29 year old male who sustained open right femoral and tibial fractures following two motor vehicle collisions. He was deemed too young to undergo TKA by Orthopedic Surgery. It was recommended he trial diagnostic genicular nerve blocks followed by C-RFA. The procedure provided a >50% reduction in average pain with an increase in activity tolerance lasting 9 months...
April 4, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
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