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https://www.readbyqxmd.com/read/28454480/immobilization-of-ph-sensitive-cdte-quantum-dots-in-a-poly-acrylate-hydrogel-for-microfluidic-applications
#1
M Franke, S Leubner, A Dubavik, A George, T Savchenko, C Pini, P Frank, D Melnikau, Y Rakovich, N Gaponik, A Eychmüller, A Richter
Microfluidic devices present the basis of modern life sciences and chemical information processing. To control the flow and to allow optical readout, a reliable sensor material that can be easily utilized for microfluidic systems is in demand. Here, we present a new optical readout system for pH sensing based on pH sensitive, photoluminescent glutathione capped cadmium telluride quantum dots that are covalently immobilized in a poly(acrylate) hydrogel. For an applicable pH sensing the generated hybrid material is integrated in a microfluidic sensor chip setup...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28454467/investigation-of-differentially-expressed-micrornas-and-genes-in-cervical-cancer-using-an-integrated-bioinformatics-analysis
#2
Zhanzhan Xu, Yu Zhou, Fang Shi, Yexuan Cao, Thi Lan Anh Dinh, Jing Wan, Min Zhao
Cervical cancer is one of the most common types of cancer among women worldwide. In order to identify the microRNAs (miRNAs/miRs) and mRNAs associated with the carcinogenesis of cervical cancer, and to investigate the molecular mechanisms of cervical cancer, an miRNA microarray, GSE30656, and 3 mRNA microarrays, GSE63514, GSE39001 and GSE9750, for cervical cancer were retrieved from Gene Expression Omnibus. These datasets were analyzed in order to obtain differentially-expressed genes (DEGs) and miRNAs using the GEO2R tool...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454466/identification-of-molecular-characteristics-induced-by-radiotherapy-in-rectal-cancer-based-on-microarray-data
#3
Chang Ge, Mengxia Wu, Guifang Chen, Guanying Yu, Dehui Ji, Shaozhao Wang
The present study aimed to reveal the molecular characteristics induced by radiotherapy in rectal cancer at the transcriptome level. Microarray data (ID, GSE26027) downloaded from the Gene Expression Omnibus database were re-analyzed to identify differentially expressed genes (DEGs) between rectal cancer tissues during and prior to radiotherapy. The DEGs were then inputted into the database for annotation, visualization and integrated discovery, an online tool to perform enrichment analyses, and into the search tool for the retrieval of interacting genes/proteins database to identify protein-protein interactions (PPIs)...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454465/microarray-based-analysis-of-gene-regulation-by-mesenchymal-stem-cells-in-breast-cancer
#4
Ming Zhang, Chang E Gao, Wen Hui Li, Yi Yang, Li Chang, Jian Dong, Yan Xin Ren, De Dian Chen
Breast cancer is one of the most common malignant tumors with a high case-fatality rate among women. The present study aimed to investigate the effects of mesenchymal stem cells (MSCs) on breast cancer by exploring the potential underlying molecular mechanisms. The expression profile of GSE43306, which refers to MDA-MB-231 cells with or without a 1:1 ratio of MSCs, was downloaded from Gene Expression Omnibus database for differentially expressed gene (DEG) screening. The Database for Annotation, Visualization and Integrated Discovery was used for gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis for DEGs...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454461/prognostic-value-of-mlh1-promoter-methylation-in-male-patients-with-esophageal-squamous-cell-carcinoma
#5
Dongping Wu, Xiaoying Chen, Yan Xu, Haiyong Wang, Guangmao Yu, Luping Jiang, Qingxiao Hong, Shiwei Duan
The DNA mismatch repair (MMR) gene MutL homolog 1 (MLH1) is critical for the maintenance of genomic integrity. Methylation of the MLH1 gene promoter was identified as a prognostic marker for numerous types of cancer including glioblastoma, colorectal, ovarian and gastric cancer. The present study aimed to determine whether MLH1 promoter methylation was associated with survival in male patients with esophageal squamous cell carcinoma (ESCC). Formalin-fixed, paraffin-embedded ESCC tissues were collected from 87 male patients...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454442/identification-of-target-genes-of-cediranib-in-alveolar-soft-part-sarcoma-using-a-gene-microarray
#6
Wenhua Jiang, Pengfei Liu, Xiaodong Li, Ping Wang
The aim of the present study was to identify the target genes of cediranib and the associated signaling pathways in alveolar soft part sarcoma (ASPS). A microarray dataset (GSE32569) was obtained from the Gene Expression Omnibus database. The R software package was used for data normalization and screening of differentially expressed genes (DEGs). The Database for Annotation, Visualization and Integrated Discovery was used to perform Gene Ontology analysis. Gene Set Enrichment Analysis was performed to obtain the up- and downregulated pathways in ASPS...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454390/expression-of-novel-cancer-testis-antigen-tmem31-increases-during-metastatic-melanoma-progression
#7
Jiaqiang Li, Xiaowen Zou, Cailing Li, Jianhua Zhong, Yan Chen, Xiaoyue Zhang, Fuming Qi, Mengshuo Li, Zhiming Cai, Aifa Tang
Cancer/testis (CT) antigens are promising targets for immunotherapy due to their restricted expression in the germ cells of the testis in healthy tissue and high immunogenicity. The aim of the present study was to determine whether transmembrane protein 31 (TMEM31) is a CT antigen and to investigate the pattern of TMEM31 expression during the progression of melanoma. The pattern of expression of human TMEM31 mRNA in multiple human tissues was determined through reverse transcription-polymerase chain reaction analysis...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454338/ellagic-acid-and-annona-muricata-in-the-chemoprevention-of-hpv-related-pre-neoplastic-lesions-of-the-cervix
#8
Giulia Morosetti, Anna Angela Criscuolo, Flavia Santi, Carlo Federico Perno, Emilio Piccione, Marco Ciotti
Ellagic acid is a phenolic compound naturally present in nuts and berries. Several studies have demonstrated that this bioactive compound has antioxidant, chemopreventive and antiviral activity. Annona muricata is a type of fruit tree with a long history of traditional use. A number of properties have been attributed to different parts of the plant, including anticancer and antioxidant activities. In the current study, a complex based on ellagic acid, Annona Muricata and antioxidant factors (an ellagic acid complex) was administered to a group of human papilloma virus (HPV) infected women with and without cervical lesions, for 12 months...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454163/image-recovery-from-defocused-2d-fluorescent-images-in-multimodal-digital-holographic-microscopy
#9
Xiangyu Quan, Osamu Matoba, Yasuhiro Awatsuji
A technique of three-dimensional (3D) intensity retrieval from defocused, two-dimensional (2D) fluorescent images in the multimodal digital holographic microscopy (DHM) is proposed. In the multimodal DHM, 3D phase and 2D fluorescence distributions are obtained simultaneously by an integrated system of an off-axis DHM and a conventional epifluorescence microscopy, respectively. This gives us more information of the target; however, defocused fluorescent images are observed due to the short depth of field. In this Letter, we propose a method to recover the defocused images based on the phase compensation and backpropagation from the defocused plane to the focused plane using the distance information that is obtained from a 3D phase distribution...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454157/wavelength-division-multiplexed-light-source-monolithically-integrated-on-a-silicon-photonics-platform
#10
P Purnawirman, Nanxi Li, E Salih Magden, Gurpreet Singh, Michele Moresco, Thomas N Adam, Gerard Leake, Douglas Coolbaugh, Jonathan D B Bradley, Michael R Watts
We demonstrate monolithic integration of a wavelength division multiplexed light source for silicon photonics by a cascade of erbium-doped aluminum oxide (Al<sub>2</sub>O<sub>3</sub>:Er<sup>3+</sup>) distributed feedback (DFB) lasers. Four DFB lasers with uniformly spaced emission wavelengths are cascaded in a series to simultaneously operate with no additional tuning required. A total output power of -10.9  dBm is obtained from the four DFBs with an average side mode suppression ratio of 38...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454134/self-stabilization-of-an-optical-frequency-comb-using-a-short-path-length-interferometer
#11
James P Cahill, Weimin Zhou, Curtis R Menyuk
We stabilized the repetition rate of an optical frequency comb using a self-referenced phase-locked loop. The phase-locked loop generated its error signal with a fiber-optic delay-line interferometer that had a path-length difference of 8 m. We used the stabilized repetition rate to generate a 10 GHz signal with a single-sideband phase noise that was limited by environmental noise to -120  dBc/Hz at an offset frequency of 1 kHz. Modeling results indicate that thermoconductive noise sets a fundamental phase noise limit for an 8 m interferometer of -152  dBc/Hz at a 1 kHz offset frequency...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454131/uni-directional-wavelength-conversion-in-silicon-using-four-wave-mixing-driven-by-cross-polarized-pumps
#12
Bryn A Bell, Chunle Xiong, David Marpaung, Colin J McKinstrie, Benjamin J Eggleton
We demonstrate optical frequency conversion between telecom wavelengths using four-wave mixing Bragg scattering powered by two pump pulses polarized on orthogonal axes of a silicon waveguide. This allows conversion in a single frequency direction while, with co-polarized pumps, the signal is redshifted or blueshifted with similar efficiency. Our approach exploits the birefringence of the waveguide and its effect on the phase matching of the four-wave mixing process. The blue or red direction can be selected by the input polarization of the signal, and 20 dB extinction ratios are observed with the unintended direction...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454127/sn-based-waveguide-p-i-n-photodetector-with-strained-gesn-ge-multiple-quantum-well-active-layer
#13
Yu-Hui Huang, Guo-En Chang, Hui Li, H H Cheng
We report on Sn-based p-i-n waveguide photodetectors (WGPD) with a pseudomorphic GeSn/Ge multiple-quantum-well (MQW) active layer on a Ge-buffered Si substrate. A reduced dark-current density of 59  mA/cm<sup>2</sup> was obtained at a reverse bias of 1 V due to the suppressed strain relaxation in the GeSn/Ge active layer. Responsivity experiments revealed an extended photodetection range covering the O, E, S, C, and L telecommunication bands completely due to the bandgap reduction resulting from Sn-alloying...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454126/stabilized-microwave-frequency-transfer-using-optical-phase-sensing-and-actuation
#14
Sascha W Schediwy, David R Gozzard, Simon Stobie, J A Malan, Keith Grainge
We present a stabilized microwave-frequency transfer technique that is based on optical phase sensing and optical phase actuation. This technique shares several attributes with optical-frequency transfer and, therefore, exhibits several advantages over other microwave-frequency transfer techniques. We demonstrated the stabilized transfer of an 8000 MHz microwave-frequency signal over a 166 km metropolitan optical fiber network, achieving a fractional frequency stability of 6.8×10<sup>-14</sup>  Hz/Hz at 1 s integration and 5...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454116/neuroprotection-by-ifn-%C3%AE-via-astrocyte-secreted-il-6-in-acute-neuroinflammation
#15
Lijie Sun, Yan Li, Xiuzhi Jia, Qi Wang, Yue Li, Minghui Hu, Linlu Tian, Jinfeng Yang, Wenjing Xing, Weihua Zhang, Jingtao Wang, Hongwei Xu, Lihua Wang, Dekai Zhang, Huan Ren
Inflammation eliminates pathogenic infections while also threatening the integrity of the central nervous system. In this study, using in vivo and in vitro models of acute neuroinflammation, we investigated the mechanisms by which inflammation and astrocytes affect neuronal apoptosis. The in vitro model mimicked acute neuroinflammation by incubation in IFN-γ-containing media with primary cultured cerebellar granule neurons, with or without cultured astrocytes. This quickly induced neuronal apoptosis characterized by cleaved caspase-3 expression, Hoechst 33342 staining, and intercellular Ca2+ influx, whereas the presence of astrocytes significantly protected neurons from these effects...
April 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454110/personalizing-chinese-medicine-by-integrating-molecular-features-of-diseases-and-herb-ingredient-information-application-to-acute-myeloid-leukemia
#16
REVIEW
Lin Huang, Haichang Li, Duoli Xie, Tieliu Shi, Chengping Wen
Traditional Chinese Medicine (TCM) has been widely used as a complementary medicine in Acute Myeloid Leukemia (AML) treatment. In this study, we proposed a new classification of Chinese Medicines (CMs) by integrating the latest discoveries in disease molecular mechanisms and traditional medicine theory. We screened out a set of chemical compounds on basis of AML differential expression genes and chemical-protein interactions and then mapped them to Traditional Chinese Medicine Integrated Database. 415 CMs contain those compounds and they were categorized into 8 groups according to the Traditional Chinese Pharmacology...
April 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454068/biochar-based-water-treatment-systems-as-a-potential-low-cost-and-sustainable-technology-for-clean-water-provision
#17
REVIEW
Willis Gwenzi, Nhamo Chaukura, Chicgoua Noubactep, Fungai N D Mukome
Approximately 600 million people lack access to safe drinking water, hence achieving Sustainable Development Goal 6 (Ensure availability and sustainable management of water and sanitation for all by 2030) calls for rapid translation of recent research into practical and frugal solutions within the remaining 13 years. Biochars, with excellent capacity to remove several contaminants from aqueous solutions, constitute an untapped technology for drinking water treatment. Biochar water treatment has several potential merits compared to existing low-cost methods (i...
April 25, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28454063/interaction-of-amino-acid-functionalized-silver-nanoparticles-and-candida-albicans-polymorphs-a-deep-uv-fluorescence-imaging-study
#18
Radovan Dojčilović, Jelena D Pajović, Dušan K Božanić, Una Bogdanović, Vesna V Vodnik, Suzana Dimitrijević-Branković, Miona G Miljković, Slavka Kaščaková, Matthieu Réfrégiers, Vladimir Djoković
The interaction of the tryptophan functionalized Ag nanoparticles and live Candida albicans cells was studied by synchrotron excitation deep-ultraviolet (DUV) fluorescence imaging at the DISCO beamline of Synchrotron SOLEIL. DUV imaging showed that incubation of the fungus with functionalized nanoparticles results in significant increase in the fluorescence signal. The analysis of the images revealed that the interaction of the nanoparticles with (pseudo)hyphae polymorphs of the diploid fungus was less pronounced than in the case of yeast cells or budding spores...
April 23, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28454042/cortical-plasticity-and-levodopa-induced-dyskinesias-in-parkinson-s-disease-connecting-the-dots-in-a-multicomponent-network
#19
REVIEW
Roopa Rajan, Traian Popa, Angelo Quartarone, Maria Felice Ghilardi, Asha Kishore
Levodopa-induced dyskinesias are motor complications following long term dopaminergic therapy in Parkinson's disease (PD). Impaired brain plasticity resulting in the creation of aberrant motor maps intended to encode normal voluntary movement is proposed to result in the development of dyskinesias. Traditionally, the various nodes in the motor network like the striato-cortical and the cerebello-thalamic loops were thought to function independent of each other with little communication among them. Anatomical evidence from primates revealed the existence of reciprocal loops between the basal ganglia and the cerebellum providing an anatomical basis for communication between the motor network loops...
April 10, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28454030/pesticide-impact-study-in-the-peri-urban-horticultural-area-of-gran-la-plata-argentina
#20
Tomás M Mac Loughlin, Leticia Peluso, Damián J G Marino
Vegetable production systems are characterized by intense pesticide use, yet the effects on the surrounding environment are largely unknown and need to be studied. Given this knowledge gap, the objective of this work is to determine the impact of horticulture on a representative watercourse by conducting an integrated study of the occurrence and concentration of pesticides in bottom sediments and their relation to lethal and sublethal effects on benthic fauna. Two sampling campaigns were conducted during seasons of low and high pesticide application in five sites along the Carnaval creek, located in the peri-urban area of La Plata City (Buenos Aires, Argentina)...
April 25, 2017: Science of the Total Environment
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