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https://www.readbyqxmd.com/read/28545271/-effect-of-microrna-106b-on-the-invasion-and-proliferation-of-trophoblasts-through-targeting-mmp-2
#1
J Li, J M Wang, Y H Liu, Z Zhang, N Han, J Y Wang, S H Xue, P Wang
Objective: To investigate the expression of microRNA-106b (miR-106b) in the placentas of patients with pre-eclampsia and its relationship with matrix metallopeptidase (MMP) -2, and its effect on the invasion and proliferation of trophoblasts. Methods: (1) Placental tissues were collected from patients with mild pre-eclampsia (mPE, n=30), severe pre-eclampsia (sPE, n=30) and normal pregnant women (n=40). Human choriocarcinoma cell lines JAR and JEG3 were assigned to the miR-106b mimics group, the mimics negative control group, the miR-106b inhibitor group and the inhibitor negative control group, respectively...
May 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28545253/encapsulation-of-the-antioxidant-r-%C3%AE-lipoic-acid-in-permethylated-%C3%AE-and-%C3%AE-cyclodextrins-thermal-and-x-ray-structural-characterization-of-the-1-1-inclusion-complexes
#2
Mino R Caira, Susan A Bourne, Buntubonke Mzondo
The naturally occurring compound α-lipoic acid (ALA) is implicated in manifold critical biological roles and its potent antioxidant properties and potential for treatment of various diseases have led to its widespread use as a dietary supplement. However, shortcomings of poor aqueous solubility and low thermal stability have hampered its development as a medicinal agent, prompting the use of cyclodextrins (CDs) to address these problems. The paucity of published structural data on the nature of the interactions between ALA and CDs motivated the present study, which describes the synthesis and X-ray structural elucidation of crystalline inclusion complexes between the biologically relevant R-(+)-α-lipoic acid (RALA) and the host molecules permethylated α-CD (TMA) and permethylated β-CD (TMB)...
May 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28545247/how-does-psychosocial-behavior-contribute-to-cognitive-health-in-old-age
#3
Robert S Wilson, David A Bennett
With the aging of the U.S. population, the number of cognitively disabled persons is expected to substantially increase in coming decades, underscoring the urgent need for effective interventions. Here, we review the current evidence linking psychosocial factors to late-life cognitive loss and consider the study design needed to illuminate the biologic bases of the associations. We then examine an ongoing study that includes several of the key design elements, the Rush Memory and Aging Project. In this longitudinal clinical-pathological cohort study, indicators of personality, social connectedness, and psychological well-being were shown to predict late-life cognitive outcomes...
May 23, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28545233/hydrothermal-synthesis-of-nanooctahedra-mnfe%C3%A2-o%C3%A2-onto-the-wood-surface-with-soft-magnetism-fire-resistance-and-electromagnetic-wave-absorption
#4
Hanwei Wang, Qiufang Yao, Chao Wang, Zhongqing Ma, Qingfeng Sun, Bitao Fan, Chunde Jin, Yipeng Chen
In this study, nanooctahedra MnFe₂O₄ were successfully deposited on a wood surface via a low hydrothermal treatment by hydrogen bonding interactions. As-prepared MnFe₂O₄/wood composite (MW) had superior performance of soft magnetism, fire resistance and electromagnetic wave absorption. Among them, small hysteresis loops and low coercivity (<±5 Oe) were observed in the magnetization-field curve of MW with saturation magnetization of 28.24 emu/g, indicating its excellent soft magnetism. The MW also exhibited a good fire-resistant property due to its initial burning time at 20 s; while only 6 s for the untreated wood (UW) in combustion experiments...
May 23, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28545222/the-effect-of-education-through-short-message-service-sms-messages-on-diabetic-patients-adherence
#5
Wirawan Adikusuma, Nurul Qiyaam
Poor adherence and a lack of understanding of medication instructions for oral antidiabetic use are key factors that inhibit the control of glycemic levels. The aforementioned situation needs intervention to improve medication adherence and the therapy. This study was conducted with a quasi-experimental design with prospective data collection. The subjects of this study were 50 outpatients with type 2 diabetes melitus (T2DM) who had received oral antidiabetic medicine therapy at least six months prior to adherence measurement...
May 12, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28545215/fertilizer-performance-of-liquid-fraction-of-digestate-as-synthetic-nitrogen-substitute-in-silage-maize-cultivation-for-three-consecutive-years
#6
I Sigurnjak, C Vaneeckhaute, E Michels, B Ryckaert, G Ghekiere, F M G Tack, E Meers
Following changes over recent years in fertilizer legislative framework throughout Europe, phosphorus (P) is taking over the role of being the limiting factor in fertilizer application rate of animal manure. This results in less placement area for spreading animal manure. As a consequence, more expensive and energy demanding synthetic fertilizers are required to meet crop nutrient requirements despite existing manure surpluses. Anaerobic digestion followed by mechanical separation of raw digestate, results in liquid fraction (LF) of digestate, a product poor in P but rich in nitrogen (N) and potassium (K)...
May 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28545208/spatio-temporal-analysis-of-particulate-matter-intake-fractions-for-vehicular-emissions-hourly-variation-by-micro-environments-in-the-greater-toronto-and-hamilton-area-canada
#7
Weeberb J Requia, Matthew D Adams, Altaf Arain, Petros Koutrakis, Wan-Chen Lee, Mark Ferguson
Previous investigations have reported intake fraction (iF) for different environments, which include ambient concentrations (outdoor exposure) and microenvironments (indoor exposure). However, little is known about iF variations due to space-time factors, especially in microenvironments. In this paper, we performed a spatio-temporal analysis of particulate matter (PM2.5) intake fractions for vehicular emissions. Specifically, we investigated hourly variation (12:00am-11:00pm) by micro-environments (residences and workplaces) in the Greater Toronto and Hamilton Area (GTHA), Canada...
May 20, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28545207/quality-and-reactivity-of-dissolved-organic-matter-in-a-mediterranean-river-across-hydrological-and-spatial-gradients
#8
Elisabet Ejarque, Anna Freixa, Eusebi Vazquez, Alba Guarch, Stefano Amalfitano, Stefano Fazi, Anna M Romaní, Andrea Butturini
Understanding DOM transport and reactivity in rivers is essential to having a complete picture of the global carbon cycle. In this study, we explore the effects of hydrological variability and downstream transport on dissolved organic matter (DOM) dynamics in a Mediterranean river. We sampled the main stem of the river Tordera from the source to the sea, over a range of fifteen hydrological conditions including extreme events (flood and drought). By exploring spatial and temporal gradients of DOM fluorescence properties, river hydrology was found to be a significant predictor of DOM spatial heterogeneity...
May 20, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28545205/organic-composition-and-multiphase-stable-isotope-analysis-of-active-degrading-and-restored-blanket-bog
#9
Laura McAnallen, Rory Doherty, Neil Ogle
Here we used organic composition and stable isotopic analysis to evaluate the effects of drainage and restoration at an ombrotrophic peatland, to assess whether rewetting of blanket bogs will reverse degradation. The organic composition of the peat and the isotopic fractionation between the solid (peat), liquid (pore water) and gas (soil gas) phases on actively accumulating, degrading and restored locations are compared. Fourier Transform Infrared Spectroscopy (FTIR) analysis of the organic material has shown a high level of humification (low decomposition) in the active peat...
May 20, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28545203/influence-of-urban-vegetation-on-air-pollution-and-noise-exposure-a-case-study-in-gothenburg-sweden
#10
Jenny Klingberg, Malin Broberg, Bo Strandberg, Pontus Thorsson, Håkan Pleijel
Air pollution levels (NO2, PAHs, O3) were investigated, before (BLE) and after (ALE) leaf emergence, in the urban landscape of Gothenburg, Sweden. The aims were to study the 1) spatial and temporal variation in pollution levels between urban green areas, 2) effect of urban vegetation on air pollution levels at the same distance from a major emission source (traffic route), 3) improvement of urban air quality in urban parks compared to adjacent sites near traffic, 4) correlation between air pollution and noise in a park...
May 20, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28545202/memantine-inhibits-degradation-of-the-articular-cartilage-extracellular-matrix-induced-by-advanced-glycation-end-products-ages
#11
Jijun Zhao, Yinghao Yu, Zhaofeng Wu, Ling Wang, Wei Li
The accumulation of inflammation and cartilage damage induced by advanced glycation end products (AGEs) are important hallmarks of osteoarthritis (OA). Memantine is a clinically licensed drug used for the treatment of moderate and severe Alzheimer's disease. To date, little information has been reported regarding the effects of memantine on cartilage destruction. In this study, we investigated the protective effects of memantine on AGE-induced degradation of collagen II and aggrecans in human SW1353 chondrocytes...
May 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28545197/congruence-between-preferred-and-actual-participation-roles-increases-satisfaction-with-treatment-decision-making-among-japanese-women-with-breast-cancer
#12
Keiko Yamauchi, Motoyuki Nakao, Mitsuyo Nakashima, Yoko Ishihara
Objective: This study investigated the correlation between participation in the treatment decision-making process and satisfaction with the process among Japanese women with breast cancer. The influence of sociodemographic and clinical characteristics on satisfaction with the treatment decision-making process was also examined. Methods: We conducted a cross-sectional, self-administered internet survey of 650 Japanese women with breast cancer in March 2016. Decisional role (active, collaborative, passive) in the treatment decision-making was elicited using the Japanese version of the Control Preference Scale...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28545188/clinacanthus-nutans-hexane-extracts-induce-apoptosis-through-a-caspase-dependent-pathway-in-human-cancer-cell-lines
#13
Pei Ying Ng, Soi Moi Chye, Chew Hee Ng, Rhun Yian Koh, Yee Lian Tiong, Liew Phing Pui, Yong Hui Tan, Crystale Siew Ying Lim, Khuen Yen Ng
Background: Clinacanthus nutans (C.nutans) is a plant consumed as a cancer treatment in tropical Asia. Despite the availability of numerous anecdotal reports, evaluation of active anticancer effects has remained elusive. Therefore we here examined antiproliferative, reactive oxygen species (ROS)-inducing and apoptosis mechanisms of whole plant extracts in different cancer cell lines. Methods: Antiproliferative actions of five solvent extracts (hexane, chloroform, ethyl acetate, methanol and water) of C.nutans were tested on non-small cell lung cancer (A549), nasopharygeal cancer (CNE1) and liver cancer (HepG2) cells using MTT assay...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28545156/the-boron-transporter-bnac4-bor1-1c-is-critical-for-inflorescence-development-and-fertility-under-boron-limitation-in-brassica-napus
#14
Quan Zhang, Haifei Chen, Mingliang He, Zhuqing Zhao, Hongmei Cai, Guangda Ding, Lei Shi, Fangsen Xu
Boron (B) is an essential micronutrient for plants, but the molecular mechanisms underlying the uptake and distribution of B in allotetraploid rapeseed (Brassica napus) are unclear. Here, we identified a B transporter of rapeseed, BnaC4.BOR1;1c, which expressed in shoot nodes and involved in distributing B to the reproductive organs. Transgenic Arabidopsis plants containing a BnaC4.BOR1;1c promoter-driven GUS reporter gene showed strong GUS activity in roots, nodal regions of the shoots and immature floral buds...
May 25, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28545149/persistence-of-lineage-iv-peste-des-petits-ruminants-virus-within-israel-since-1993-an-evolutionary-perspective
#15
Brian Clarke, Mana Mahapatra, Orly Friedgut, Velizar Bumbarov, Satya Parida
Peste-des-petits ruminants (PPR) is one of the most important infectious diseases of domesticated small ruminants. From the initial identification in 1942 in West Africa, PPR virus (PPRV) has spread throughout much of the developing world. PPRV is now considered endemic throughout Africa, with the notable exception of South Africa, the Middle-East and Israel, as well as South-, East-, and Central Asia. Despite this widespread dispersal, the evolution and transmission of PPRV in endemic populations is not well understood...
2017: PloS One
https://www.readbyqxmd.com/read/28545144/quantitative-descriptions-of-rice-plant-architecture-and-their-application
#16
Xumeng Li, Xiaohui Wang, Yulin Peng, Hailin Wei, Xinguang Zhu, Shuoqi Chang, Ming Li, Tao Li, Huang Huang
Plant architecture is an important agronomic trait, and improving plant architecture has attracted the attention of scientists for decades, particularly studies to create desirable plant architecture for high grain yields through breeding and culture practices. However, many important structural phenotypic traits still lack quantitative description and modeling on structural-functional relativity. This study defined new architecture indices (AIs) derived from the digitalized plant architecture using the virtual blade method...
2017: PloS One
https://www.readbyqxmd.com/read/28545143/haemophilus-parasuis-cytolethal-distending-toxin-induces-cell-cycle-arrest-and-p53-dependent-apoptosis
#17
Gang Li, Hui Niu, Yanhe Zhang, Yanling Li, Fang Xie, Paul R Langford, Siguo Liu, Chunlai Wang
Haemophilus parasuis is the causative agent of Glasser's disease in pigs. Cytolethal distending toxin (CDT) is an important virulence factor of H. parasuis. It is composed of three subunits: CdtA, CdtB and CdtC and all were successfully expressed in soluble form in Escherichia coli when the signal peptides were removed. Purified CdtB had DNase activity, i.e. caused DNA double strand damage, in vitro and in vivo prior to cell arrest and apoptosis. Flow cytometry analysis showed CdtB alone could induce cell cycle arrest and apoptosis in PK-15 porcine kidney and pulmonary alveolar macrophage (PAM) cells, which could be enhanced by CdtA or/and CdtC...
2017: PloS One
https://www.readbyqxmd.com/read/28545141/prion-pathogenesis-is-unaltered-in-the-absence-of-sirp%C3%AE-mediated-don-t-eat-me-signaling
#18
Mario Nuvolone, Marta Paolucci, Silvia Sorce, Veronika Kana, Rita Moos, Takashi Matozaki, Adriano Aguzzi
Prion diseases are neurodegenerative conditions caused by misfolding of the prion protein, leading to conspicuous neuronal loss and intense microgliosis. Recent experimental evidence point towards a protective role of microglia against prion-induced neurodegeneration, possibly through elimination of prion-containing apoptotic bodies. The molecular mechanisms by which microglia recognize and eliminate apoptotic cells in the context of prion diseases are poorly defined. Here we investigated the possible involvement of signal regulatory protein α (SIRPα), a key modulator of host cell phagocytosis; SIRPα is encoded by the Sirpa gene that is genetically linked to the prion gene Prnp...
2017: PloS One
https://www.readbyqxmd.com/read/28545135/maximum-flow-based-resilience-analysis-from-component-to-system
#19
Chong Jin, Ruiying Li, Rui Kang
Resilience, the ability to withstand disruptions and recover quickly, must be considered during system design because any disruption of the system may cause considerable loss, including economic and societal. This work develops analytic maximum flow-based resilience models for series and parallel systems using Zobel's resilience measure. The two analytic models can be used to evaluate quantitatively and compare the resilience of the systems with the corresponding performance structures. For systems with identical components, the resilience of the parallel system increases with increasing number of components, while the resilience remains constant in the series system...
2017: PloS One
https://www.readbyqxmd.com/read/28545130/responses-of-absolute-and-specific-enzyme-activity-to-consecutive-application-of-composted-sewage-sludge-in-a-fluventic-ustochrept
#20
Xiao Liu, Kangli Guo, Lin Huang, Zhengyu Ji, Huimin Jiang, Hu Li, Jianfeng Zhang
Composted sewage sludge (CS) is considered a rich source of soil nutrients and significantly affects the physical, chemical, and biological characteristics of soil, but its effect on specific enzyme activity in soil is disregarded. The present experiment examined the absolute and specific enzyme activity of the enzymes involved in carbon, nitrogen, and phosphorus cycles, the diversity of soil microbial functions, and soil community composition in a Fluventic Ustochrept under a maize-wheat rotation system in North China during 2012-2015...
2017: PloS One
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