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https://www.readbyqxmd.com/read/29045954/-pulmonary-arterial-hypertension-as-leading-manifestation-of-methylmalonic-aciduria-clinical-characteristics-and-gene-testing-in-15-cases
#1
X Q Liu, H Yan, J X Qiu, C Y Zhang, J G Qi, X Zhang, H J Xiao, Y L Yang, Y H Chen, J B DU
OBJECTIVE: To deepen our understanding of Methylmalonic aciduria (MMA) associated pulmonary hypertension (PH) by analyzing the characteristics of clinical presentation, pulmonary high resolusion CT(HRCT), treatment response and gene mutation. METHODS: This study includes 15 cases of pediatric patients with MMA associated PH diagnosed and treated in Peking University First Hospital pediatric department between May 2012 and May 2016 with symptoms of PH as their leading presentation...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045944/prevalence-estimates-of-rare-congenital-anomalies-by-integrating-two-population-based-registries-in-tuscany-italy
#2
Alessio Coi, Michele Santoro, Anna Pierini, Sonia Marrucci, Federica Pieroni, Fabrizio Bianchi
BACKGROUND/AIMS: Population-based registries play a key role in the epidemiological surveillance of congenital anomalies (CAs). This study is aimed at improving the epidemiological surveillance and providing prevalence estimates of rare CAs using the Registry of Rare Diseases as an added data source to the Registry of Congenital Anomalies. METHODS: Cases of diagnosed rare CAs (2006-2013) were extracted from the Tuscany Registry of Rare Diseases and the Tuscany Registry of Congenital Anomalies in order to set up an integrated dataset...
September 19, 2017: Public Health Genomics
https://www.readbyqxmd.com/read/29045560/inflammatory-gastrointestinal-diseases-associated-with-pd-1-blockade-antibodies
#3
M Collins, Jm Michot, Fx Danlos, C Mussini, E Soularue, C Mateus, D Loirat, A Buisson, I Rosa, O Lambotte, S Laghouati, N Chaput, C Coutzac, Al Voisin, Jc Soria, A Marabelle, S Champiat, C Robert, F Carbonnel
Background: Immune check-point blockade agents have shown clinical activity in cancer patients but are associated with immune-related adverse events that could limit their development. The aim of this study was to describe the gastrointestinal immune-related adverse events (GI-irAE) in patients with cancer treated with anti-PD-1. Methods: this is a retrospective study of consecutive adult patients who had a suspected GI-irAE due to anti-PD-1 antibodies between 2013 and 2016...
October 3, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29045239/contour-propagation-for-lung-tumor-delineation-in-4d-ct-using-tensor-product-surface-of-uniform-and-non-uniform-closed-cubic-b-splines
#4
Renchao Jin, Yongchuan Liu, Mi Chen, Sheng Zhang, Enmin Song
A robust contour propagation method is proposed to help physicians delineate lung tumors on all phase images of four-dimensional computer tomography (4D-CT) by only manually delineating the contours on a reference phase. The proposed method models the trajectory surface swept by a contour in a respiratory cycle as a tensor-product surface of two closed cubic B-spline curves: a non-uniform B-spline curve which models the contour and a uniform B-spline curve which models the trajectory of a point on the contour...
October 18, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29045205/effect-of-a-hospital-wide-measure-on-the-readmissions-reduction-program
#5
Rachael B Zuckerman, Karen E Joynt Maddox, Steven H Sheingold, Lena M Chen, Arnold M Epstein
BACKGROUND: The Hospital Readmissions Reduction Program penalizes hospitals that have high 30-day readmission rates across specific conditions. There is support for changing to a hospital-wide readmission measure to broaden hospital eligibility and provide incentives for improvement across more conditions. METHODS: We used Medicare claims from 2011 through 2013 to evaluate the number of hospitals that were eligible for penalties, in that they met a volume threshold of 25 admissions over a 3-year period for a specific condition or 25 admissions over a 1-year period for the cohorts included in the hospital-wide measure...
October 19, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29044796/social-traits-social-networks-and-evolutionary-biology
#6
David N Fisher, Andrew G McAdam
The social environment is both an important agent of selection for most organisms, and an emergent property of their interactions. As an aggregation of interactions among members of a population, the social environment is a product of many sets of relationships, and so can be represented as a network or matrix. Social network analysis in animals has focused on why these networks possess the structure they do, and whether individuals' network traits, representing some aspect of their social phenotype, relate to their fitness...
October 17, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29044522/an-automated-two-dimensional-form-registration-method-for-osteological-pair-matching
#7
Jeffrey James Lynch
This study introduces an automated method for osteological pair-matching using two-dimensional outline form data extracted from photographs. A procedure for acquiring photographs that improve the differentiation of specimens from the background is presented along with an extraction procedure that allows the capture of form data from photographs. The raw form data are used in a two-dimensional registration procedure, which combines iterative closest point, K-nearest neighbor search, and iterations around an estimated mean...
October 16, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29043478/the-compensatory-enlargement-of-the-remaining-thyroid-lobe-following-hemithyroidectomy-is-small-and-without-impact-on-symptom-relief
#8
Frederik Schultz Pustelnik, Casper Gronbek, Helle Døssing, Nina Nguyen, Steen Joop Bonnema, Laszlo Hegedüs, Christian Godballe, Jesper Roed Sorensen
According to previous studies, hemithyroidectomy results in growth of the remaining thyroid lobe by up to 30% in first 12 months after surgery. However, this estimate is based on imprecise methods, high inter- and intra-observer variability, and lack of blinding of the measurements. Furthermore, it is unknown whether enlargement of the remaining hemi-thyroid interferes with the improvement in symptoms after surgery for goiter. We aimed to assess the impact of postoperative thyroid growth on goiter symptom relief following hemithyroidectomy in patients with benign nodular goiter...
October 17, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29043084/multi-species-genetic-connectivity-in-a-terrestrial-habitat-network
#9
Robby R Marrotte, Jeff Bowman, Michael G C Brown, Chad Cordes, Kimberley Y Morris, Melanie B Prentice, Paul J Wilson
BACKGROUND: Habitat fragmentation reduces genetic connectivity for multiple species, yet conservation efforts tend to rely heavily on single-species connectivity estimates to inform land-use planning. Such conservation activities may benefit from multi-species connectivity estimates, which provide a simple and practical means to mitigate the effects of habitat fragmentation for a larger number of species. To test the validity of a multi-species connectivity model, we used neutral microsatellite genetic datasets of Canada lynx (Lynx canadensis), American marten (Martes americana), fisher (Pekania pennanti), and southern flying squirrel (Glaucomys volans) to evaluate multi-species genetic connectivity across Ontario, Canada...
2017: Movement Ecology
https://www.readbyqxmd.com/read/29043022/using-genetic-tools-to-estimate-the-prevalence-of-non-native-red-deer-cervus-elaphus-in-a-western-european-population
#10
Alain C Frantz, Frank E Zachos, Sabine Bertouille, Marie-Christine Eloy, Marc Colyn, Marie-Christine Flamand
Game species like the red deer have been subjected to anthropogenic impacts for centuries. Translocations are often carried out-sometimes illegally-not only for sporting purposes, but also to increase trophy quality, reduce inbreeding, or mitigate bottlenecks after excessive persecution. Apart from the blurring of large-scale genetic structure, translocations without adequate quarantine measure risk introducing pathogens into potentially immunologically naïve populations. It is therefore important to understand the frequency of clandestine translocations...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29042396/differentiated-thyroid-cancer-millions-spent-with-no-tangible-gain
#11
Luis Furuya-Kanamori, Art Sedrakyan, Adedayo A Onitilo, Nasser Bagheri, Paul Glasziou, Suhail A R Doi
The incidence of differentiated thyroid cancer (DTC) has rapidly increased worldwide over the last decades. It is unknown if the increase in diagnosis has been mirrored by an increase in thyroidectomy rates with the concomitant economic impact that this would have on the healthcare system. DTC and thyroidectomy incidence as well as DTC specific mortality were modelled using Poisson regression in New South Wales (NSW), Australia per year and by sex. The incidence of 2002 was the point from which the increase in rates were assessed cumulatively over the subsequent decade...
October 17, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29041971/finnish-physicians-stress-related-to-information-systems-keeps-increasing-a-longitudinal-three-wave-survey-study
#12
Tarja Heponiemi, Hannele Hyppönen, Tuulikki Vehko, Sari Kujala, Anna-Mari Aalto, Jukka Vänskä, Marko Elovainio
BACKGROUND: Poorly functioning, time-consuming, and inadequate information systems are among the most important work-related psychosocial factors causing stress in physicians. The present study examined the trend in the perceived stress that was related to information systems (SRIS) among Finnish physicians during a nine-year follow-up. In addition, we examined the associations of gender, age, employment sector, specialization status, leadership position, on-call burden, and time pressure with SRIS change and levels...
October 17, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29041444/vortex-topographic-microscopy-for-full-field-reference-free-imaging-and-testing
#13
Petr Bouchal, Lenka Štrbková, Zbyněk Dostál, Zdeněk Bouchal
Light vortices carry orbital angular momentum and have a variety of applications in optical manipulation, high-capacity communications or microscopy. Here we propose a new concept of full-field vortex topographic microscopy enabling a reference-free displacement and shape measurement of reflective samples. The sample surface is mapped by an array of light spots enabling quantitative reconstruction of the local depths from defocused wavefronts. Light from the spots is converted to a lattice of mutually uncorrelated double-helix point spread functions (PSFs) whose angular rotation enables depth estimation...
September 4, 2017: Optics Express
https://www.readbyqxmd.com/read/29040816/lamin-a-c-mutation-associated-with-lipodystrophy-influences-adipogenic-differentiation-of-stem-cells-through-interaction-with-notch-signaling
#14
Ksenia Perepelina, Renata I Dmitrieva, Elena Ignatieva, Aleksandra Borodkina, Anna Kostareva, Anna Malashicheva
Lamin A/C is involved in many cellular functions due to its ability to bind chromatin and transcription factors and affect their properties. Mutations of LMNA gene encoding lamin A/C affect differentiation capacity of stem cells. However, signaling pathways involved in interaction with lamins in cellular differentiation remain unclear. Lipodystrophy associated with LMNA mutation R482L causes loss of fat tissue. In this study we investigated the role of LMNA mutation R482L in modulating Notch signaling activity in adipogenic differentiation of mesenchymal stem cells...
October 17, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29040777/efficient-imaging-examining-the-value-of-ultrasound-in-the-diagnosis-of-traumatic-adult-brachial-plexus-injuries-a-systematic-review
#15
Brian Chin, Maleka Ramji, Forough Farrokhyar, James R Bain
INTRODUCTION: Traumatic brachial plexus injury (BPI) can result in debilitating sequelae of the upper extremity. Presently, therapeutic decisions are based on the mechanism of injury, serial physical examination, electromyography, nerve conduction, and imaging studies. While magnetic resonance imaging is the current imaging modality of choice for BPI, ultrasound is a promising newcomer that is inexpensive, accessible, and available at point of care. OBJECTIVE: To evaluate ultrasound as a diagnostic tool in the assessment of traumatic adult BPI through a systematic review...
October 11, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29040767/contribution-of-the-s-type-anion-channel-slac1-to-stomatal-control-and-its-dependence-on-developmental-stage-in-rice
#16
Kensuke Kusumi, Ayana Hashimura, Yoshiko Yamamoto, Juntaro Negi, Koh Iba
Rice production depends on water availability and carbon fixation by photosynthesis. Therefore, optimal control of stomata, which regulate leaf transpiration and CO2 absorption, is important for high productivity. SLAC1 is an S-type anion channel protein that controls stomatal closure in response to elevated CO2. Rice slac1 mutants showed significantly increased stomatal conductance (gs) and enhanced CO2 assimilation. To discern the contribution of stomatal regulation to rice growth, we compared gs among wild-type (WT) and two mutants, slac1 and the dominant-positive mutant SLAC1-F461A, which expresses a point mutation causing an amino acid substitution (F461A) in SLAC1, at different growth stages...
October 5, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29040353/sociodemographic-differences-between-alcohol-use-and-sickness-absence-pooled-analysis-of-four-cohort-studies
#17
Jenni Ervasti, Mika Kivimäki, Jenny Head, Marcel Goldberg, Guillaume Airagnes, Jaana Pentti, Tuula Oksanen, Paula Salo, Sakari Suominen, Markus Jokela, Jussi Vahtera, Marie Zins, Marianna Virtanen
Aims: We examined differences in sickness absence in relation to at-risk drinking and abstinence, taking into account potential changes in consumption. Methods: We used individual-participant data (n = 46,514) from four prospective cohort studies from Finland, France and the UK. Participants responded to a survey on alcohol use at two time points 4-6 years apart, and were linked to records of sickness absence for an ~6-year follow-up after the latter survey. Abstainers were those reporting no alcohol use in either survey...
October 13, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29040031/prospective-randomized-double-blind-phase-iii-clinical-trial-of-anti-t-lymphocyte-globulin-to-assess-impact-on-chronic-graft-versus-host-disease-free-survival-in-patients-undergoing-hla-matched-unrelated-myeloablative-hematopoietic-cell-transplantation
#18
Robert J Soiffer, Haesook T Kim, Joseph McGuirk, Mitchell E Horwitz, Laura Johnston, Mrinal M Patnaik, Witold Rybka, Andrew Artz, David L Porter, Thomas C Shea, Michael W Boyer, Richard T Maziarz, Paul J Shaughnessy, Usama Gergis, Hana Safah, Ran Reshef, John F DiPersio, Patrick J Stiff, Madhuri Vusirikala, Jeff Szer, Jennifer Holter, James D Levine, Paul J Martin, Joseph A Pidala, Ian D Lewis, Vincent T Ho, Edwin P Alyea, Jerome Ritz, Frank Glavin, Peter Westervelt, Madan H Jagasia, Yi-Bin Chen
Purpose Several open-label randomized studies have suggested that in vivo T-cell depletion with anti-T-lymphocyte globulin (ATLG; formerly antithymocyte globulin-Fresenius) reduces chronic graft-versus-host disease (cGVHD) without compromising survival. We report a prospective, double-blind phase III trial to investigate the effect of ATLG (Neovii Biotech, Lexington, MA) on cGVHD-free survival. Patients and Methods Two hundred fifty-four patients 18 to 65 years of age with acute leukemia or myelodysplastic syndrome who underwent myeloablative HLA-matched unrelated hematopoietic cell transplantation (HCT) were randomly assigned one to one to placebo (n =128 placebo) or ATLG (n = 126) treatment at 27 sites...
October 17, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29039755/comparing-riegl-ricopter-uav-lidar-derived-canopy-height-and-dbh-with-terrestrial-lidar
#19
Benjamin Brede, Alvaro Lau, Harm M Bartholomeus, Lammert Kooistra
In recent years, LIght Detection And Ranging (LiDAR) and especially Terrestrial Laser Scanning (TLS) systems have shown the potential to revolutionise forest structural characterisation by providing unprecedented 3D data. However, manned Airborne Laser Scanning (ALS) requires costly campaigns and produces relatively low point density, while TLS is labour intense and time demanding. Unmanned Aerial Vehicle (UAV)-borne laser scanning can be the way in between. In this study, we present first results and experiences with the RIEGL RiCOPTER with VUX ® -1UAV ALS system and compare it with the well tested RIEGL VZ-400 TLS system...
October 17, 2017: Sensors
https://www.readbyqxmd.com/read/29039320/pharmacokinetic-and-bioequivalence-studies-of-fast-dispersible-ketoprofen-tablets-in-healthy-volunteers
#20
Farya Zafar, Muhammad Harris Shoaib, Rabia Ismail Yousuf, Huma Ali, Rabia Bushra
In the present study the pharmacokinetic and bioequivalence parameter of Ketoprofen 100 mg fast dispersible tablets (test) were measured with marketed (reference) product. This study was accomplished following FDA guidance. A single dose, open labeled, cross over (two way), randomized study design was used to conduct investigation on 12 Pakistani healthy volunteers. At various time points blood samples (10mL) were drawn i.e. at 0.25, 0.5, 1, 1.5, 2, 3, 4, 8, 12 and 13hr. Plasma was then separated and ketoprofen concentrations were estimated by validated HPLC technique using LC 20A pump (Shimadzu Corp, Japan) and Spectrophotometric SPD-20Adetector (Shimadzu Corp, Japan)...
July 2017: Pakistan Journal of Pharmaceutical Sciences
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