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https://www.readbyqxmd.com/read/29245169/-mistakes-and-drawbacks-in-german-newspaper-articles-on-epidemiologic-studies-meat-consumption-and-colorectal-cancer-as-an-example
#1
Bernd Kowall, Andreas Stang
Background Results of epidemiologic studies are often reported in the media because they are of vital interest for many people. Using the example of meat consumption and colorectal cancer, we investigated whether results of epidemiologic studies are reported in an understandable and correct manner in German newspapers and magazines. Methods We gathered all articles published in 13 selected German newspapers and magazines that referred to a press release on meat consumption and colorectal cancer issued by the International Agency for Research on Cancer (IARC) on October 26th 2015...
December 15, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29244786/functional-assessment-as-a-predictor-of-cognitive-impairment-a-retrospective-cohort-study
#2
Gustavo Alberto Sandival Ampuero, Fernando M Runzer-Colmenares, José F Parodi
INTRODUCTION: It is estimated that major neurocognitive disorders will affect 115.4 million people by 2050, representing a significant financial burden for society. Likewise, functional dependence for basic or instrumental activities of daily life is usually a consequence of the greater prevalence of disabling pathologies, and of the progressive decrease of the physiological reserve due to aging. OBJECTIVES: To determine the ratio between the functional test and prediction of deterioration of cognitive function in geriatric patients...
December 12, 2017: Medwave
https://www.readbyqxmd.com/read/29243827/one-incision-versus-two-incision-techniques-for-arthroscopically-assisted-anterior-cruciate-ligament-reconstruction-in-adults
#3
REVIEW
Fernando C Rezende, Vinícius Y Moraes, Carlos Es Franciozi, Pedro Debieux, Marcus V Luzo, João Carlos Belloti
BACKGROUND: Anterior cruciate ligament (ACL) tears are serious knee injuries that are frequently treated surgically in the form of arthroscopically assisted reconstruction with grafts from the patella or hamstrings tendons. We reviewed the evidence for the choice of arthroscopically assisted ACL reconstruction technique in terms of whether it should involve one incision (femoral tunnel drilled from inside the knee joint under arthroscopic visualisation) or two incisions (femoral tunnel drilled from outside to inside the knee joint)...
December 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29243120/validated-alzheimer-s-disease-risk-index-anu-adri-is-associated-with-smaller-volumes-in-the-default-mode-network-in-the-early-60s
#4
Nicolas Cherbuin, Marnie E Shaw, Erin Walsh, Perminder Sachdev, Kaarin J Anstey
Strong evidence is available suggesting that effective reduction of exposure to demonstrated modifiable risk factors in mid-life or before could significantly decrease the incidence of Alzheimer's disease (AD) and delay its onset. A key ingredient to achieving this goal is the reliable identification of individuals at risk well before they develop clinical symptoms. The aim of this study was to provide further neuroimaging evidence of the effectiveness of a validated tool, the ANU Alzheimer's Disease Risk Index, for the assessment of future risk of cognitive decline...
December 14, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29242937/paclitaxel-with-and-without-pazopanib-for-persistent-or-recurrent-ovarian-cancer-a-randomized-clinical-trial
#5
Debra L Richardson, Michael W Sill, Robert L Coleman, Anil K Sood, Michael L Pearl, Siobhan M Kehoe, Michael E Carney, Parviz Hanjani, Linda Van Le, Xun C Zhou, Angeles Alvarez Secord, Heidi J Gray, Lisa M Landrum, Heather A Lankes, Wei Hu, Carol Aghajanian
Importance: Ovarian cancer is the leading cause of gynecologic cancer deaths in the United States. Pazopanib is an oral, multitarget kinase inhibitor of vascular endothelial growth factor receptors 1, 2, and 3; platelet-derived growth factor receptors α and β; and proto-oncogene receptor tyrosine kinase (c-KIT). Objective: To estimate the progression-free survival (PFS) hazard ratio (HR) of weekly paclitaxel and pazopanib compared with weekly paclitaxel and placebo in women with recurrent ovarian cancer...
December 14, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29242726/relationship-between-dual-time-point-fdg-pet-ct-and-clinical-prognostic-indexes-in-patients-with-high-grade-lymphoma-a-pilot-study
#6
Do Hyoung Lim, Jai Hyuen Lee
Purpose: This study investigated the correlative relationship between metabolic parameters estimated from dual time point 2-deoxy-2-[18F] fluoro-D-glucose (18F-FDG) positron emission tomography/computerized tomography (PET/CT) and the clinical tools predicting the outcome of a lymphoma. We also measured metabolic and volumetric alterations between early and delayed 18F-FDG PET/CT in patients with high grade lymphoma (HGL). Methods: The samples were 122 lymph nodes and extralymphatic lesions from 26 patients diagnosed with HGL...
December 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29242157/determination-of-green-s-function-for-three-dimensional-traction-force-reconstruction-based-on-geometry-and-boundary-conditions-of-cell-culture-matrices
#7
Y Du, S C B Herath, Q G Wang, H Asada, P C Y Chen
Cell migration plays a particular important role in the initiation and progression of many physical processes and pathological conditions such as tumor invasion and metastasis. Three-dimensional traction force microscopy (TFM) of high resolution and high accuracy is being developed in an effort to unveil the underlying mechanical process of cell migration in a vivo-like environment. Linear elasticity-based TFM (LETM) as a mainstream approach relies on the Green's function (that relates traction forces to matrix deformation), of which the inherent boundary conditions and geometry of the matrix could remarkably affect the result as suggested by previous 2D studies...
December 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29241585/detection-of-velocity-and-diffusion-coefficient-change-points-in-single-particle-trajectories
#8
Shuhui Yin, Nancy Song, Haw Yang
The position-time trajectory of a biological subject moving in a complex environment contains rich information about how it interacts with the local setting. Whether the subject be an animal or an intracellular endosomal vesicle, the two primary modes of biological locomotion are directional movement and random walk, respectively characterized by velocity and diffusion coefficient. This contribution introduces a method to quantitatively divide a single-particle trajectory into segments that exhibit changes in the diffusion coefficient, velocity, or both...
December 11, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29241400/bayesian-nonparametric-inference-for-the-three-class-youden-index-and-its-associated-optimal-cutoff-points
#9
Vanda Inácio de Carvalho, Adam J Branscum
The three-class Youden index serves both as a measure of medical test accuracy and a criterion to choose the optimal pair of cutoff values for classifying subjects into three ordinal disease categories (e.g. no disease, mild disease, advanced disease). We present a Bayesian nonparametric approach for estimating the three-class Youden index and its corresponding optimal cutoff values based on Dirichlet process mixtures, which are robust models that can handle intricate features of distributions for complex data...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29240778/biopsychosocial-predictors-of-perceived-life-expectancy-in-a-national-sample-of-older-men-and-women
#10
Lindsay C Kobayashi, Rebecca J Beeken, Susanne F Meisel
Perceived life expectancy (PLE) is predictive of mortality risk in older adults, but the factors that may contribute to mental conceptions of PLE are unknown. We aimed to describe the sociodemographic, biomedical, behavioral, and psychological predictors of self-reported PLE estimates among older English adults. Data were from 6662 adults aged 50-79 years in the population-based English Longitudinal Study of Ageing (cross-sectional sample from 2012/13). PLE was assessed in the face-to-face study interview ("What are the chances you will live to be age x or more?" where x = current age plus 10-15 years)...
2017: PloS One
https://www.readbyqxmd.com/read/29240614/a-measure-of-the-potential-impact-of-hospital-community-health-activities-on-population-health-and-equity
#11
James W Begun, Linda M Kahn, Brooke A Cunningham, Jan K Malcolm, Sandra Potthoff
CONTEXT: Many hospitals in the United States are exploring greater investment in community health activities that address upstream causes of poor health. OBJECTIVE: Develop and apply a measure to categorize and estimate the potential impact of hospitals' community health activities on population health and equity. DESIGN, SETTING, AND PARTICIPANTS: We propose a scale of potential impact on population health and equity, based on the cliff analogy developed by Jones and colleagues...
December 13, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/29240580/prognostic-significance-of-periadnexal-extension-in-cutaneous-melanoma-and-its-implications-for-pathologic-reporting-and-staging
#12
Tristan J Dodds, Serigne Lo, Louise Jackett, Omgo Nieweg, John F Thompson, Richard A Scolyer
Tumor thickness is the strongest predictor of outcome for clinically localized melanoma. Therefore, accurate assessment is critical for appropriate staging, reliable estimation of prognosis, and management. When melanoma extends alongside skin adnexal structures more deeply than the main tumor mass (periadnexal extension), it is currently unknown whether the prognosis is more accurately reflected by the deepest point of periadnexal tumor extension or the main tumor mass. This study sought to address this question...
December 7, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29240135/long-period-fiber-grating-a-specific-design-for-biosensing-applications
#13
Sankhyabrata Bandyopadhyay, Palas Biswas, Francesco Chiavaioli, Tanoy Kumar Dey, Nandini Basumallick, Cosimo Trono, Ambra Giannetti, Sara Tombelli, Francesco Baldini, Somnath Bandyopadhyay
In this paper, a detailed investigation on the modeling of long-period fiber grating (LPFG) sensors is discussed with the aim of providing a more realistic solution for their use in biosensing. Add-layer sensitivity, i.e., sensitivity of the sensor to an additional layer adhered onto the fiber surface, is quantified and a clear and complete analysis about the influence of the average thickness of the deposited biological sensing layers, as well as the change in refractive index of these layers, on the resonant wavelength of the cladding modes of an LPFG is provided...
December 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29239987/body-composition-of-women-s-ice-hockey-players-comparison-of-estimates-using-skinfolds-and-idxa
#14
Kajsa Gilenstam, Christina A Geithner
The purpose of this study was to compare percent fat (% Fat) estimates from anthropometric equations using skinfolds (SKF) in women's ice hockey players to estimates obtained from Lunar iDXA. Data were collected on 19 elite female Swedish hockey players (mean age ± SD = 18.4 ± 2.4 y). Four skinfolds (SKF) (triceps, abdominal, suprailiac, and thigh) were measured within two hours of iDXA assessments. The % Fat estimates from iDXA and four anthropometric equations were compared using paired t-tests, and a one-way ANOVA was used to compare % Fat estimates from the anthropometric equations...
December 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29239983/effects-of-2-dehydration-on-lactate-concentration-during-constant-load-cycling
#15
J M Green, Miller Bl, J D Simpson, Dubroc Dr, Keyes Aa, Neal Kk, Gann Jj, Andre Tl
The lactate [La] threshold can predict endurance performance potential. Dehydration may alter [La] threshold. This study examined effects of dehydration on [La] response during constant load cycling. Recreationally fit (VO2 peak = 48.7 ± 5.2 ml•kg•min) male participants (n=9) completed 2 x 40 min constant-load cycling trials; euhydrated (HYD) and following previous evening passive (water bath) dehydration (2% body weight, DEH) (HYD and DEH counterbalanced). [La], heart rate (HR), 10 point Omni Ratings of Perceived Exertion (RPE) and rectal temperature (Trec) were measured following warm-up and at 10, 20, 30, and 40 min...
December 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29239570/spatial-analysis-of-the-prevalence-of-schistosomiasis-in-an-endemic-coastal-area-in-north-eastern-brazil
#16
Allan D Santos, Jonhnatas Silva, Ana Caroline Lima, Márcio Santos, Shirley Lima, Monalisa Amor, Carlos Santos, Arthur Vasconcelos, Silvio Dolabella, Karina C G M Araújo
Due to contact and misuse of water drainage channels, schistosomiasis has spread and become a constant concern in northeastern Brazil. The aim of this study was to monitor human cases of Schistosomiasis mansoni and the breeding areas of the snail intermediate host Biomphalaria glabrata through spatial analysis in a community named Invasão do Canal do Guaxinim, located in Barra dos Coqueiros City in an endemic coastal part of the state of Sergipe, Brazil. This research was performed as a cross-sectional epidemiological study conducted with parasitological and malacological surveys...
November 27, 2017: Geospatial Health
https://www.readbyqxmd.com/read/29239343/surgery-and-considerations-for-the-repair-of-petersen-s-space-hernia-after-mini-gastric-bypass
#17
Borja Camacho Fernández-Pacheco, Eudaldo López-Tomassetti Fernández, Juan Ramón Hernández Hernández
This paper reports a case of Petersen's space hernia after mini gastric bypass. This is an anecdotal post-operative complication in the mini gastric bypass technique, with an estimated rate of 1/5000 cases. Similar cases described in the literature were treated by the surgical hernia reduction and the closure of the mesenteric defect. Our patient had a unique management, performing a conversion to Roux-en-Y gastric bypass with dissection of the biliopancreatic limb at the anastomosis and creation of a variable foot-point anastomosis with excellent mid-term post-operative results...
January 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29239292/ethnic-density-effects-for-adult-mental-health-systematic-review-and-meta-analysis-of-international-studies
#18
Laia Bécares, Michael E Dewey, Jayati Das-Munshi
BACKGROUND: Despite increased ethnic diversity in more economically developed countries it is unclear whether residential concentration of ethnic minority people (ethnic density) is detrimental or protective for mental health. This is the first systematic review and meta-analysis covering the international literature, assessing ethnic density associations with mental health outcomes. METHODS: We systematically searched Medline, PsychINFO, Sociological Abstracts, Web of Science from inception to 31 March 2016...
December 14, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29238873/insights-into-the-generation-of-monoclonal-antibody-acidic-charge-variants-during-chinese-hamster-ovary-cell-cultures
#19
Hongping Tang, Shiwei Miao, Xintao Zhang, Li Fan, Xuping Liu, Wen-Song Tan, Liang Zhao
Charge variation is one of the most important heterogeneities during monoclonal antibody (mAb) manufacturing and this study presents insights into the generation of acidic charge variants during cell culture processes. Since acidic variants generate both intracellularly and extracellularly, main charge fraction collected by weak cation exchange chromatography (WCX) was incubated in harvested cell supernatant (HCS) to simulate and investigate the extracellular process firstly. It is found that the main fraction was degraded rapidly into acidic variants rather than basic variants extracellularly, and the degradation sites were located in both Fab and Fc fragments indicated by papain digestion...
December 13, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29238588/the-role-of-tips-in-the-management-of-liver-transplant-candidates
#20
Lukas W Unger, Theresa Stork, Theresa Bucsics, Susanne Rasoul-Rockenschaub, Katharina Staufer, Michael Trauner, Svenja Maschke, Max Pawloff, Thomas Soliman, Thomas Reiberger, Gabriela A Berlakovich
Background: Transjugular intrahepatic portosystemic shunt (TIPS) implantation is used for treatment of several complications in patients with liver cirrhosis. Recent studies have identified a survival benefit for patients on the waiting list after TIPS implantation, but the optimal time point for TIPS implantation prior to orthotopic liver transplantation (OLT) has not been established. Study: This study retrospectively assessed patients undergoing TIPS implantation before or after listing for OLT at the Medical University of Vienna...
December 2017: United European Gastroenterology Journal
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