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https://www.readbyqxmd.com/read/28222484/overweight-obese-underweight-and-frequency-of-sugar-consumption-as-risk-indicators-for-early-childhood-caries-in-brazilian-preschool-children
#1
Cecilia Claudia Costa Ribeiro, Mariana Carvalho Batista da Silva, Ana Margarida Melo Nunes, Erika Bárbara de Abreu Fonseca Thomaz, Cadidja Dayane Sousa Carmo, Marizélia Rodrigues Costa Ribeiro, Antônio Augusto Moura da Silva
BACKGROUND: A possible association between being overweight or obese and early childhood caries (ECC) remains controversial. AIM: To investigated this association in a developing country testing the confounding effects of socioeconomic factors and frequency of sugar consumption. METHODS: Historical cohort study, 388 children (aged 24-71 months) living in São Luís, Brazil. A theoretical model adjusted according to income, birthweight, and nutritional status at twelve months and frequency of sugar consumption was generated with directed acyclic graphs to analyze this association...
February 21, 2017: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/28222395/technetium-99m-radiolabeled-paclitaxel-as-an-imaging-probe-for-breast-cancer-in-vivo
#2
Liziane O F Monteiro, Renata S Fernandes, Luciano C Castro, Valbert N Cardoso, Mônica C Oliveira, Danyelle M Townsend, Alice Ferretti, Domenico Rubello, Elaine A Leite, André L B de Barros
The high incidence and mortality of breast cancer supports efforts to develop innovative imaging probes to effectively diagnose, evaluate the extent of the tumor, and predict the efficacy of tumor treatments while concurrently and selectively delivering anticancer agents to the cancer tissue. In the present study we described the preparation of technetium-99m ((99m)Tc)-labeled paclitaxel (PTX) and evaluated its feasibility as a radiotracer for breast tumors (4T1) in BALB/c mice. Thin Layer Chromatography (TLC) was used to determine the radiochemical purity and in vitro stability of (99m)Tc-PTX...
February 17, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28222259/band-alignment-at-gan-single-layer-wse2-interface
#3
Malleswararao Tangi, Pawan Mishra, Chien-Chih Tseng, Tien Khee Ng, Mohamed Nejib Hedhili, Dalaver H Anjum, Mohd Sharizal Alias, Nini Wei, Lain-Jong Li, Boon S Ooi
We study the band discontinuity at the GaN/single-layer (SL) WSe2 heterointerface. The GaN thin layer is epitaxially grown by molecular beam epitaxy on chemically vapor deposited SL-WSe2/c-sapphire. We confirm that the WSe2 was formed as an SL from structural and optical analyses using atomic force microscopy, scanning transmission electron microscopy, micro-Raman, absorbance, and micro-photoluminescence spectra. The determination of band offset parameters at the GaN/SL-WSe2 heterojunction is obtained by high-resolution x-ray photoelectron spectroscopy, electron affinities and the electronic bandgap values of SL-WSe2 and GaN...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28222009/alzheimer-s-and-danish-dementia-peptides-induce-cataract-and-perturb-retinal-architecture-in-rats
#4
G Bhanuprakash Reddy, P Yadagiri Reddy, Avadhesha Surolia
Familial Danish dementias (FDDs) are autosomal dominant neurodegenerative disorders that are associated with visual defects. In some aspects, FDD is similar to Alzheimer's disease (AD)- the amyloid deposits in FDD and AD are made of short peptides: amyloid β (Aβ) in AD and ADan in FDD. Previously, we demonstrated an interaction between the dementia peptides and α-crystallin leading to lens opacification in organ culture due to impaired chaperone activity of α-crystallin. Herein, we report the in vivo effects of ADan and Aβ on the eye...
February 21, 2017: Biomolecular Concepts
https://www.readbyqxmd.com/read/28221856/enumeration-and-identification-of-coliform-bacteria-injured-by-chlorine-or-fungicide-mixed-with-agricultural-water
#5
Hidemi Izumi, Yuji Nakata, Ayano Inoue
Chemical sanitizers may induce no injury (bacteria survive), sublethal injury (bacteria are injured), or lethal injury (bacteria die). The proportion of coliform bacteria that were injured sublethally by chlorine and fungicide mixed with agricultural water (pond water), which was used to dilute the pesticide solution, was evaluated using the thin agar layer (TAL) method. In pure cultures of Enterobacter cloacae , Escherichia coli , and E. coli O157:H7 (representing a human pathogen), the percentage of chlorine-injured cells was 69 to 77% for dilute electrolyzed water containing an available chlorine level of 2 ppm...
October 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28221803/effects-of-thickness-on-the-metal-insulator-transition-in-free-standing-vanadium-dioxide-nanocrystals
#6
Mustafa M Fadlelmula, Engin Can Sürmeli, Mehdi Ramezani, Talip Serkan Kasırga
Controlling solid state phase transitions via external stimuli offers rich physics along with possibilities of unparalleled applications in electronics and optics. The well-known metal-insulator transition (MIT) in vanadium dioxide (VO2) is one instance of such phase transitions emerging from strong electronic correlations. Inducing the MIT using electric field has been investigated extensively for the applications in electrical and ultrafast optical switching. However, as the Thomas-Fermi screening length is very short, for considerable alteration in the material's properties with electric field induced MIT, crystals below 10 nm are needed...
February 21, 2017: Nano Letters
https://www.readbyqxmd.com/read/28221802/surface-segregation-and-bulk-aggregation-in-an-athermal-thin-film-of-polymer-nanoparticle-blends-strategies-of-controlling-phase-behavior
#7
Chih-Yu Teng, Yu-Jane Sheng, Heng-Kwong Tsao
The phase behavior of an athermal film of a polymer-nanoparticle blend (PNB) driven by depletion attraction is investigated by dissipative particle dynamics for nanospheres and nanocubes. Surface segregation is observed at low nanoparticle concentrations while bulk aggregation is seen at high concentrations. Surface excess and the aggregation number can be controlled by tuning the nanoparticle concentration. As surface-roughened or polymer-grafted nanoparticles are used, uniform PNBs are acquired due to the lack of depletion...
February 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28221800/self-associating-poly-ethylene-oxide-block-poly-%C3%AE%C2%B5-caprolactone-peo-b-pcl-drug-conjugates-for-the-delivery-of-stat3-inhibitor-jsi-124-potential-application-in-cancer-immunotherapy
#8
Shyam M Garg, Mohammad Reza Vakili, Ommoleila Molavi, Afsaneh Lavasanifar
Constitutive activation of signal transducer and activator of transcription 3 (STAT3) in tumor cells and tumor associated dendritic cells (DCs) plays a major role in the progression of cancer. JSI-124 (Cucurbitacin I) is a potent inhibitor of STAT3, however, its poor solubility and non-specificity limits its effectiveness in cancer immunotherapy. In order to achieve a nano-carrier for solubilisation and passive targeting of JSI-124 to tumor cells and tumor associated DCs, the drug was chemically conjugated to pendent COOH groups of self-associating poly(ethylene oxide)-block-poly(-carboxylate-ε-caprolactone) (PEO-b-PCCL)...
February 21, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28221161/morphology-directed-self-assembly-and-pattern-transfer-from-a-high-molecular-weight-polystyrene-block-poly-dimethylsiloxane-block-copolymer-film
#9
Li-Chen Cheng, Wubin Bai, Eduardo Martin, Kun-Hua Tu, Konstantinos Ntetsikas, George Liontos, Apostolos Avgeropoulos, Caroline Ross
The self-assembly of block copolymers with large feature sizes is inherently challenging as the large kinetic barrier arising from chain entanglement of high molecular weight polymers limits the extent over which long-range ordered microdomains can be achieved. Here, we illustrate the evolution of thin film morphology from a diblock copolymer of polystyrene-block-poly(dimethylsiloxane) exhibiting total number average molecular weight of 123 kg/mol, and demonstrate the formation of layers of well-ordered cylindrical microdomains under appropriate conditions of binary solvent mix ratio, commensurate film thickness, and solvent vapor annealing time...
February 21, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28221044/tunable-volumetric-density-and-porous-structure-of-spherical-poly-%C3%A9-caprolactone-microcarriers-as-applied-in-human-mesenchymal-stem-cell-expansion
#10
Jian Li, Alan Tin-Lun Lam, Jessica Pei Wen Toh, Shaul Reuveny, Steve Kah-Weng Oh, William R Birch
Polymeric microspheres may serve as microcarrier matrices, for the expansion of anchorage-dependent stem cells. They require surface properties that both promote initial cell adhesion and the subsequent spreading of cells, which is a prerequisite for successful expansion. When implemented in a three-dimensional culture environment, under agitation, their suspension under low shear rates depends on the microcarriers having a modest negative buoyancy, with a density of 1.02-1.05 g/cm(3). Bioresorbable polycaprolactone (PCL), with a density of 1...
February 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28221026/nanomechanics-of-ph-responsive-drug-loaded-bi-layered-polymer-grafts
#11
Prathima Chandra Nalam, Hyun-Su Lee, Nupur Bhatt, Robert W Carpick, David M Eckmann, Russell J Composto
Stimuli-responsive polymer films play an important role in the development of smart antibacterial coatings. In this study, we consider complementary architectures of polyelectrolyte films including a thin chitosan layer (CH), poly (acrylic acid) (PAA) brushes and a bilayer structure of CH grafted to PAA brushes (CH/PAA) as possible candidates for targeted drug delivery platforms. Atomic force microscopy (AFM) was employed to study the structure-mechanical property relationship for these mono- and bi- layered polymer grafts at pH 7...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28220763/exfoliation-of-black-phosphorus-in-ionic-liquids
#12
Miyeon Lee, Arup Kumer Roy, Seongho Jo, Yujin Choi, Ari Chae, Bongsoo Kim, Sung Yong Park, Insik In
We report the characterization and formation of sonication-assisted liquid phase exfoliation of bulk black phosphorus (BP) crystals with the incorporation of two representative ionic liquids (ILs) ([Emim][Tf2N] and [Bmim][Tf2N]) as green dispersing media was attempted, which resulted in stable dispersion of multi-layer BP flakes with unsuspected high oxidation resistance and chemical/structural integrity due to the presence of IL layer on top of BP flakes. There are two unveiled issues for the generation of BP dispersion in ILs...
February 21, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28220705/comparison-of-methods-for-determining-the-mechanical-properties-of-semiconducting-polymer-films-for-stretchable-electronics
#13
Daniel Rodriquez, Jae-Han Kim, Samuel E Root, Zhuping Fei, Pierre Boufflet, Martin Heeney, Taek-Soo Kim, Darren J Lipomi
This paper describes a comparison of two characterization techniques for determining the mechanical properties of thin-film organic semiconductors for applications in soft electronics. In the first method, the film is supported by water (film-on-water, FOW), and a stress-strain curve is obtained using a direct tensile test. In the second method, the film is supported by an elastomer (film-on-elastomer, FOE), and is subjected to three tests to reconstruct the key features of the stress-strain curve: the buckling test (tensile modulus), the onset of buckling (yield point), and the crack-onset strain (strain at fracture)...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28219996/electrical-tuning-of-the-polarization-state-of-light-using-graphene-integrated-anisotropic-metasurfaces
#14
Shourya Dutta-Gupta, Nima Dabidian, Iskandar Kholmanov, Mikhail A Belkin, Gennady Shvets
Plasmonic metasurfaces have been employed for moulding the flow of transmitted and reflected light, thereby enabling numerous applications that benefit from their ultra-thin sub-wavelength format. Their appeal is further enhanced by the incorporation of active electro-optic elements, paving the way for dynamic control of light's properties. In this paper, we realize a dynamic polarization state generator using a graphene-integrated anisotropic metasurface (GIAM) that converts the linear polarization of the incident light into an elliptical one...
March 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28219993/low-prevalence-of-substandard-and-falsified-antimalarial-and-antibiotic-medicines-in-public-and-faith-based-health-facilities-of-southern-malawi
#15
Felix Khuluza, Stephen Kigera, Lutz Heide
Substandard and falsified antimalarial and antibiotic medicines represent a serious problem for public health, especially in low- and middle-income countries. However, information on the prevalence of poor-quality medicines is limited. In the present study, samples of six antimalarial and six antibiotic medicines were collected from 31 health facilities and drug outlets in southern Malawi. Random sampling was used in the selection of health facilities. For sample collection, an overt approach was used in licensed facilities, and a mystery shopper approach in nonlicensed outlets...
February 20, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28219007/electrochemistry-of-the-4fe4s-cluster-in-base-excision-repair-proteins-tuning-the-redox-potential-with-dna
#16
Phillip Leon Bartels, Andy Zhou, Anna Ruth Arnold, Nicole N Nunez, Frank Nelson Crespilho, Sheila S David, Jacqueline K Barton
Escherichia coli Endonuclease III (EndoIII) and MutY are DNA glycosylases that contain [4Fe4S] clusters and that serve to maintain the integrity of the genome after oxidative stress. Electrochemical studies on highly-oriented pyrolytic graphite (HOPG) revealed that DNA binding by EndoIII leads to a large negative shift in midpoint potential of the cluster, consistent with stabilization of the oxidized [4Fe4S]3+ form. However, the smooth, hydrophobic HOPG surface is non-ideal for working with proteins in the absence of DNA...
February 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28218833/atomic-force-microscopy-thermally-assisted-microsampling-with-atmospheric-pressure-temperature-ramped-thermal-desorption-ionization-mass-spectrometry-analysis
#17
William D Hoffmann, Vilmos Kertesz, Bernadeta R Srijanto, Gary J Van Berkel
The use of atomic force microscopy controlled nanothermal analysis probes for reproducible spatially resolved thermally assisted sampling of micrometer-sized areas (ca. 11 × 17 μm wide × 2.4 μm deep) from relatively low number-average molecular weight (Mn < 3000) polydisperse thin films of poly(2-vinylpyridine) (P2VP) is presented. Following sampling, the nanothermal analysis probes were moved up from the surface and the probe temperature ramped to liberate the sampled materials into the gas phase for atmospheric pressure chemical ionization and mass spectrometric analysis...
February 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28218821/co2-catalysis
#18
EDITORIAL
Arjan W Kleij, Michael North, Atsushi Urakawa
Out of thin air: In this Editorial, the Guest Editors introduce a Special Issue on Carbon Dioxide Conversion Catalysis, discuss its importance in modern chemical processes, and highlight a few examples of its use in industry, such as the synthesis of cyclic carbonates and the conversion of CO2 into fuels.
February 20, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28218741/identification-of-micrornas-associated-with-invasive-and-aggressive-phenotype-in-cutaneous-melanoma-by-next-generation-sequencing
#19
Sankhiros Babapoor, Rong Wu, James Kozubek, Donna Auidi, Jane M Grant-Kels, Soheil S Dadras
A comprehensive repertoire of human microRNAs (miRNAs) that could be involved in early melanoma invasion into the dermis remains unknown. To this end, we sequenced small RNAs (18-30 nucleotides) isolated from an annotated series of invasive melanomas (average invasive depth, 2.0 mm), common melanocytic nevi, and matched normal skin (n=28). Our previously established bioinformatics pipeline identified 765 distinct mature known miRNAs and defined a set of top 40 list that clearly segregated melanomas into thin (0...
February 20, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28218731/a-single-use-in-vitro-biosensor-for-the-detection-of-t-tau-protein-a-biomarker-of-neuro-degenerative-disorders-in-pbs-and-human-serum-using-differential-pulse-voltammetry-dpv
#20
Yifan Dai, Alireza Molazemhosseini, Chung Chiun Liu
A single-use, in vitro biosensor for the detection of T-Tau protein in phosphate-buffer saline (PBS) and undiluted human serum was designed, manufactured, and tested. Differential pulse voltammetry (DPV) served as the transduction mechanism. This biosensor consisted of three electrodes: working, counter, and reference electrodes fabricated on a PET sheet. Both working and counter electrodes were thin gold film, 10 nm in thickness. Laser ablation technique was used to define the size and structure of the biosensor...
February 19, 2017: Biosensors
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