keyword
MENU ▼
Read by QxMD icon Read
search

thinning

keyword
https://www.readbyqxmd.com/read/27933585/effect-of-rheology-and-poloxamers-properties-on-release-of-drugs-from-silicon-dioxide-gel-filled-hard-gelatin-capsules-a-further-enhancement-of-viability-of-liquid-semisolid-matrix-technology
#1
Misbah Sultana, Mobashar Ahmad Butt, Tariq Saeed, Rizwan Mahmood, Saeed Ul Hassan, Khalid Hussain, Syed Atif Raza, Muhammad Ahsan, Nadeem Irfan Bukhari
The liquid and semisolid matrix technology, filling liquids, semi-solids and gels in hard gelatin capsule are promising, thus, there is a need of enhanced research interest in the technology. Therefore, the present study was aimed to investigate isoniazid (freely soluble) and metronidazole (slightly soluble) gels filled in hard gelatin capsules for the effect of poloxamers of different viscosities on release of the drugs. Gel of each drug (10% w/w, particle size 180-250 μm), prepared by mixing poloxamer and 8% w/w hydrophilic silicon dioxide (Aerosil® A200), was assessed for rheology, dispersion stability and release profile...
December 8, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27932881/preparation-and-antitumor-evaluation-of-self-assembling-oleanolic-acid-loaded-pluronic-p105-d-%C3%AE-tocopheryl-polyethylene-glycol-succinate-mixed-micelles-for-non-small-cell-lung-cancer-treatment
#2
Hao Wu, Qingxiang Zhong, Rongling Zhong, Houcai Huang, Zhi Xia, Zhongcheng Ke, Zhenhai Zhang, Jie Song, Xiaobin Jia
Oleanolic acid (OA) is a triterpenoid found in various fruits and vegetables and used in traditional Chinese medicine. OA plays a crucial role in the treatment of several cancers, but poor water solubility, low permeability, and significant efflux have limited its widespread clinical use. Vitamin E-d-α-tocopheryl polyethylene glycol succinate (vitamin E-TPGS) and Pluronic P105 were used to improve the solubility and permeability and to decrease the efflux of OA. OA-loaded mixed micelles were prepared by ethanol thin-film hydration...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27932863/non-imidazole-based-histamine-h3-receptor-antagonists-with-anticonvulsant-activity-in-different-seizure-models-in-male-adult-rats
#3
Bassem Sadek, Ali Saad, Gniewomir Latacz, Kamil Kuder, Agnieszka Olejarz, Tadeusz Karcz, Holger Stark, Katarzyna Kieć-Kononowicz
A series of twelve novel non-imidazole-based ligands (3-14) was developed and evaluated for its in vitro binding properties at the human histamine H3 receptor (hH3R). The novel ligands were investigated for their in vivo protective effects in different seizure models in male adult rats. Among the H3R ligands (3-14) tested, ligand 14 showed significant and dose-dependent reduction in the duration of tonic hind limb extension in maximal electroshock (MES)-induced seizure model subsequent to acute systemic administration (5, 10, and 20 mg/kg, intraperitoneally), whereas ligands 4, 6, and 7 without appreciable protection in MES model were most promising in pentylenetetrazole (PTZ) model...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27932858/one-stage-bone-strip-reconstruction-technique-with-balloon-sinus-dilatation-surgery-for-chronic-maxillary-atelectasis
#4
Tomoyuki Kashima, Robert A Goldberg, Jocelyne C Kohn, Daniel B Rootman
PURPOSE: Chronic maxillary atelectasis is characterized by unilateral spontaneous enophthalmos and hypoglobus due to increased orbital volume secondary to maxillary sinus inward deformation. Reformation of the sinus architecture and reconstruction of the orbit are key to a successful outcome. Here, we introduce a one-staged surgery that addresses both these goals. PATIENTS AND METHODS: We retrospectively reviewed 11 patients treated with one-stage orbital and sinus surgery...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27932703/an-in%C3%A2-vivo-pilot-study-of-a-microporous-thin-film-nitinol-covered-stent-to-assess-the-effect-of-porosity-and-pore-geometry-on-device-interaction-with-the-vessel-wall
#5
Youngjae Chun, Colin P Kealey, Daniel S Levi, David A Rigberg, Yanfei Chen, Bryan W Tillman, K P Mohanchandra, Mahdis Shayan, Gregory P Carman
Sputter-deposited thin film nitinol constructs with various micropatterns were fabricated to evaluate their effect on the vessel wall in vivo when used as a covering for commercially available stents. Thin film nitinol constructs were used to cover stents and deployed in non-diseased swine arteries. Swine were sacrificed after approximately four weeks and the thin film nitinol-covered stents were removed for histopathologic evaluation. Histopathology revealed differences in neointimal thickness that correlated with the thin film nitinol micropattern...
December 8, 2016: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/27932203/neural-connection-supporting-endogenous-5-hydroxytryptamine-influence-on-autonomic-activity-in-medial-prefrontal-cortex
#6
Hao-Qiang Zhang, Yong Zhang, Lin Liu, Jin-Lian Li, Ya-Cheng Lu, Ying-Ying Yu, Hui Li, Ting Zhang, Ying-Shing Chan, Fu-Xing Zhang, Yun-Qing Li
5-hydroxytryptamine (5-HT) transmission in the medial prefrontal cortex (mPFC) enhances or suppresses signal outflow to influence emotion-/cognition-based function performances and, putatively, the autonomic responses. The top-down cortical modulation of autonomic activities may be mediated in part through projections from mPFC to brain stem dorsal vagal complex (DVC). The abundant and heterogeneous densities of 5-HT fibers across laminae in mPFC suggest serotonergic innervation of mPFC-DVC projection neurons whereby endogenous 5-HT acts to regulate autonomic activities...
December 1, 2016: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/27930877/short-term-results-from-seventy-six-patients-receiving-a-bone-anchored-hearing-implant-installed-with-a-novel-minimally-invasive-surgery-technique
#7
M L Johansson, R J Stokroos, R Banga, M K Hol, E A Mylanus, H Savage Jones, J R Tysome, P Vannucchi, J R Hof, J W Brunings, J van Tongeren, R W Lutgert, A Banerjee, J P Windfuhr, A Caruso, A L Giannuzzi, S Bordin, J Hanif, N Schart-Morén, S Singam, S Jonhede, M Holmberg, C W Cremers, M Hultcrantz
The surgical installation of bone anchored hearing systems (BAHS) has after decades finally undergone changes towards more minimally invasive techniques without soft tissue thinning. Some surgeons are also performing the surgery and installation, using the classical drilling system, through a single punch entry. This article is protected by copyright. All rights reserved.
December 8, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27930851/surfactant-free-fabrication-of-fullerene-c60-nanotubules-under-shear
#8
Kasturi Vimalanathan, Rekha Goswami Shrestha, Zhi Zhang, Jin Zou, Tomonobu Nakayama, Colin L Raston
A method for controlling the self-assembly of fullerene C60 molecules into nanotubules in the fcc phase, devoid of entrapped solvent, has been established in a thin film microfluidic device. The micron length C60 nanotubules, with individual hollow diameters of 100 to 400 nm, are formed under continuous flow processing during high shear micromixing of water and a toluene solution of the fullerene, in the absence of surfactant, and without the need for further down-stream processing. TEM revealed pores on the surface of the nanotubes, and the isolated material has a much higher response to small molecule sensing than that for analogous material formed using multistep batch processing...
December 8, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27929596/primary-solitary-intralabyrinthine-schwannoma-a-report-of-7-cases-and-a-review-of-the-literature
#9
Avi Shupak, Yehuda Holdstein, Margalit Kaminer, Itzhak Braverman
Intralabyrinthine schwannomas (ILSs) are uncommon benign tumors that originate in the Schwann cell sheath of the intralabyrinthine distal branches of the vestibulocochlear nerve. They have no initial involvement in the internal auditory canal, although that might develop later. These lesions can arise inside the cochlea, originate in the vestibule or, in rare cases, develop in the semicircular canals. From these sites, spread might take place via the anatomic connections between the perilymphatic spaces in the scala vestibuli and the anterior vestibule...
December 2016: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/27929488/production-and-quality-control-177lu-nca-dotmp-as-a-potential-agent-for-bone-pain-palliation
#10
Nafise Salek, Mojtaba Shamsaei, Mohammad Ghannadi Maragheh, Simindokht Shirvani Arani, Ali Bahrami Samani
Skeletal uptake of radiolabeled-1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetramethylene phosphoric acid (e.g., 177Lu-DOTMP) complex, is used for bone pain palliation. The moderate energy of β-emitting 177Lu (T½ = 6.7 d, Eβmax = 497keV) has been considered as a potential radionuclide for development of the bone-seeking radiopharmaceutical. Since the specific activity of the radiolabeled carrier molecules should be high, the "no-carrier-added radionuclides" have sig-nificant roles in nuclear medicine...
November 8, 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27929409/rapid-detection-methods-for-asphalt-pavement-thicknesses-and-defects-by-a-vehicle-mounted-ground-penetrating-radar-gpr-system
#11
Zehua Dong, Shengbo Ye, Yunze Gao, Guangyou Fang, Xiaojuan Zhang, Zhongjun Xue, Tao Zhang
The thickness estimation of the top surface layer and surface layer, as well as the detection of road defects, are of great importance to the quality conditions of asphalt pavement. Although ground penetrating radar (GPR) methods have been widely used in non-destructive detection of pavements, the thickness estimation of the thin top surface layer is still a difficult problem due to the limitations of GPR resolution and the similar permittivity of asphalt sub-layers. Besides, the detection of some road defects, including inadequate compaction and delamination at interfaces, require further practical study...
December 6, 2016: Sensors
https://www.readbyqxmd.com/read/27929406/a-thin-film-nanocomposite-membrane-with-mcm-41-silica-nanoparticles-for-brackish-water-purification
#12
Mohammed Kadhom, Jun Yin, Baolin Deng
Thin film nanocomposite (TFN) membranes containing MCM-41 silica nanoparticles (NPs) were synthesized by the interfacial polymerization (IP) process. An m-phenylenediamine (MPD) aqueous solution and an organic phase with trimesoyl chloride (TMC) dissolved in isooctane were used in the IP reaction, occurring on a nanoporous polysulfone (PSU) support layer. Isooctane was introduced as the organic solvent for TMC in this work due to its intermediate boiling point. MCM-41 silica NPs were loaded in MPD and TMC solutions in separate experiments, in a concentration range from 0 to 0...
December 6, 2016: Membranes
https://www.readbyqxmd.com/read/27929180/electrically-controlled-release-of-insulin-using-polypyrrole-nanoparticles
#13
Niloufar Hosseini-Nassab, Devleena Samanta, Yassan Abdolazimi, Justin P Annes, Richard N Zare
Conducting polymers present an opportunity for developing programmable, adjustable, spatially, and temporally controllable drug delivery systems. While several small molecule drugs have been released from thin conductive polymeric films successfully, delivering large molecule therapeutics, such as polypeptides and nucleic acids, has remained a significant challenge. Poor drug loading (∼ng cm(-2)) of thin films coupled with film instability has, in many cases, made conducting polymer films refractory to clinical development...
December 8, 2016: Nanoscale
https://www.readbyqxmd.com/read/27929139/a-piezoelectric-micro-generator-worked-at-low-frequency-and-high-acceleration-based-on-pzt-and-phosphor-bronze-bonding
#14
Gang Tang, Bin Yang, Cheng Hou, Guimiao Li, Jingquan Liu, Xiang Chen, Chunsheng Yang
Recently, piezoelectric energy harvesters (PEHs) have been paid a lot of attention by many researchers to convert mechanical energy into electrical and low level vibration. Currently, most of PEHs worked under high frequency and low level vibration. In this paper, we propose a micro cantilever generator based on the bonding of bulk PZT wafer and phosphor bronze, which is fabricated by MEMS technology, such as mechanical chemical thinning and etching. The experimental results show that the open-circuit output voltage, output power and power density of this fabricated prototype are 35 V, 321 μW and 8664 μW cm(-3) at the resonant frequency of 100...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27929133/two-different-phase-change-origins-with-chemical-and-structural-phase-changes-in-c-doped-1-5%C3%A2-wt-in3sb1te2
#15
Y M Lee, S Y Lee, T Sasaki, K Kim, D Ahn, M-C Jung
We fabricated C-doped (1.5 wt.%) In3Sb1Te2 (CIST) thin films with amorphous phase (a-CIST) using a sputter method. Two electrical-phase-changes at 250 and 275 °C were observed in the sheet resistance measurement. In order to understand the origin of these electrical-phase-changes, all samples were characterized by XRD, TEM, and HRXPS with synchrotron radiation. In a-CIST, only weak Sb-C bonding was observed. In the first electrical-phase-change at 250 °C, strong Sb-C bonding occurred without an accompanying structural/phase change (still amorphous)...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27929125/totally-embedded-hybrid-thin-films-of-carbon-nanotubes-and-silver-nanowires-as-flat-homogenous-flexible-transparent-conductors
#16
Suresh Kumar Raman Pillai, Jing Wang, Yilei Wang, Md Moniruzzaman Sk, Ari Bimo Prakoso, Rusli, Mary B Chan-Park
There is a great need for viable alternatives to today's transparent conductive film using largely indium tin oxide. We report the fabrication of a new type of flexible transparent conductive film using silver nanowires (AgNW) and single-walled carbon nanotube (SWCNT) networks which are fully embedded in a UV curable resin substrate. The hybrid SWCNTs-AgNWs film is relatively flat so that the RMS roughness of the top surface of the film is 3 nm. Addition of SWCNTs networks make the film resistance uniform; without SWCNTs, sheet resistance of the surface composed of just AgNWs in resin varies from 20 Ω/sq to 10(7 )Ω/sq...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27929115/tracking-the-coherent-generation-of-polaron-pairs-in-conjugated-polymers
#17
Antonietta De Sio, Filippo Troiani, Margherita Maiuri, Julien Réhault, Ephraim Sommer, James Lim, Susana F Huelga, Martin B Plenio, Carlo Andrea Rozzi, Giulio Cerullo, Elisa Molinari, Christoph Lienau
The optical excitation of organic semiconductors not only generates charge-neutral electron-hole pairs (excitons), but also charge-separated polaron pairs with high yield. The microscopic mechanisms underlying this charge separation have been debated for many years. Here we use ultrafast two-dimensional electronic spectroscopy to study the dynamics of polaron pair formation in a prototypical polymer thin film on a sub-20-fs time scale. We observe multi-period peak oscillations persisting for up to about 1 ps as distinct signatures of vibronic quantum coherence at room temperature...
December 8, 2016: Nature Communications
https://www.readbyqxmd.com/read/27929106/channel-morphology-effect-on-water-transport-through-graphene-bilayers
#18
Bo Liu, Renbing Wu, Adrian Wing-Keung Law, Xi-Qiao Feng, Lichun Bai, Kun Zhou
The application of few-layered graphene-derived functional thin films for molecular filtration and separation has recently attracted intensive interests. In practice, the morphology of the nanochannel formed by the graphene (GE) layers is not ideally flat and can be affected by various factors. This work investigates the effect of channel morphology on the water transport behaviors through the GE bilayers via molecular dynamics simulations. The simulation results show that the water flow velocity and transport resistance highly depend on the curvature of the graphene layers, particularly when they are curved in non-synergic patterns...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27929103/depth-resolved-lattice-charge-coupling-in-epitaxial-bifeo3-thin-film
#19
Hyeon Jun Lee, Sung Su Lee, Jeong Hun Kwak, Young-Min Kim, Hu Young Jeong, Albina Y Borisevich, Su Yong Lee, Do Young Noh, Owoong Kwon, Yunseok Kim, Ji Young Jo
For epitaxial films, a critical thickness (tc) can create a phenomenological interface between a strained bottom layer and a relaxed top layer. Here, we present an experimental report of how the tc in BiFeO3 thin films acts as a boundary to determine the crystalline phase, ferroelectricity, and piezoelectricity in 60 nm thick BiFeO3/SrRuO3/SrTiO3 substrate. We found larger Fe cation displacement of the relaxed layer than that of strained layer. In the time-resolved X-ray microdiffraction analyses, the piezoelectric response of the BiFeO3 film was resolved into a strained layer with an extremely low piezoelectric coefficient of 2...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27929053/broadband-photodetector-based-on-carbon-nanotube-thin-film-single-layer-graphene-schottky-junction
#20
Teng-Fei Zhang, Zhi-Peng Li, Jiu-Zhen Wang, Wei-Yu Kong, Guo-An Wu, Yu-Zhen Zheng, Yuan-Wei Zhao, En-Xu Yao, Nai-Xi Zhuang, Lin-Bao Luo
In this study, we present a broadband nano-photodetector based on single-layer graphene (SLG)-carbon nanotube thin film (CNTF) Schottky junction. It was found that the as-fabricated device exhibited obvious sensitivity to a wide range of illumination, with peak sensitivity at 600 and 920 nm. In addition, the SLG-CNTF device had a fast response speed (τr = 68 μs, τf = 78 μs) and good reproducibility in a wide range of switching frequencies (50-5400 Hz). The on-off ratio, responsivity, and detectivity of the device were estimated to be 1 × 10(2), 209 mAW(-1) and 4...
December 8, 2016: Scientific Reports
keyword
keyword
53232
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"