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https://www.readbyqxmd.com/read/28538105/linezolid-induced-lactic-acidosis-the-thin-line-between-bacterial-and-mitochondrial-ribosomes
#1
Alessandro Santini, Dario Ronchi, Manuela Garbellini, Daniela Piga, Alessandro Protti
Introduction - Linezolid inhibits bacterial growth by targeting bacterial ribosomes and by interfering with bacterial protein synthesis. Lactic acidosis is a rare, but potentially lethal, side effect of linezolid. Areas covered - The pathogenesis of linezolid-induced lactic acidosis is reviewed with special emphasis on aspects relevant to the recognition, prevention and treatment of the syndrome. Expert opinion - Linezolid-induced lactic acidosis reflects the untoward interaction between the drug and mitochondrial ribosomes...
May 24, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28538100/enzymatic-hydrolysis-of-polyester-thin-films-at-the-nanoscale-effects-of-polyester-structure-and-enzyme-active-site-accessibility
#2
Michael Thomas Zumstein, Daniela Rechsteiner, Nicolas Roduner, Veronika Perz, Doris Ribitsch, Georg M Guebitz, Hans-Peter E Kohler, Kristopher McNeill, Michael Sander
Biodegradable polyesters have a large potential to replace persistent polymers in numerous applications and to thereby reduce the accumulation of plastics in the environment. Ester hydrolysis by extracellular carboxylesterases is considered the rate-limiting step in polyester biodegradation. In this work, we systematically investigated the effects of polyester and carboxylesterase structure on the hydrolysis of nanometer-thin polyester films using a quartz-crystal microbalance with dissipation monitoring. Hydrolyzability increased with increasing polyester-chain flexibility as evidenced from differences in the hydrolysis rates and extents of aliphatic polyesters varying in the length of their dicarboxylic acid unit and of poly(butylene adipate co-terephthalate) (PBAT) polyesters varying in their terephthalate-to-adipate ratio by Rhizopus oryzae lipase and Fusarium solani cutinase...
May 24, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28538092/discriminating-residue-substitutions-in-a-single-protein-molecule-using-a-sub-nanopore
#3
Zhuxin Dong, Eamonn Kennedy, Mohammad Hokmabadi, Gregory Timp
It is now possible to create, in a thin inorganic membrane, a single, sub-nanometer-diameter pore, i.e. a sub-nanopore, about the size of an amino acid residue. To explore the prospects for sequencing protein with it, measurements of the force and current were performed as two denatured histones, which differed by four amino acid residue substitutions, were impelled systematically through the sub-nanopore one-at-a-time using an atomic force microscope. The force measurements revealed that once the denatured protein, stabilized by sodium dodecyl sulfate (SDS), translocated through the sub-nanopore, a disproportionately large force was required to pull it back...
May 24, 2017: ACS Nano
https://www.readbyqxmd.com/read/28538071/bone-scrapers-versus-piezoelectric-surgery-in-the-lateral-antrostomy-for-sinus-floor-elevation
#4
Claudio Stacchi, Teresa Lombardi, Paolo Cusimano, Federico Berton, Floriana Lauritano, Gabriele Cervino, Roberto Di Lenarda, Marco Cicciù
The purpose of this investigation is to evaluate 2 different methods for reducing cortical wall thickness in sinus floor augmentation surgery. A manual bone scraper was compared in terms of efficacy, speed, and safety to an ultrasonic insert for osteoplasty, in a randomized controlled clinical trial with a split-mouth design. Twenty-five patients with severe posterior maxillary atrophy were treated with bilateral sinus floor elevation with lateral approach. Antrostomies were randomly performed by eroding the cortical wall with a manual bone scraper (test site) or with an ultrasonic insert (control site) until the membrane was visible under a thin layer of bone, before outlining the window with a piezoelectric device...
May 19, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28538035/structure-function-analysis-of-nonarteritic-anterior-ischemic-optic-neuropathy-and-age-related-differences-in-outcome
#5
Ming-Hui Sun, Yaping Joyce Liao
BACKGROUND: The optic nerve head is vulnerable to ischemia leading to anterior ischemic optic neuropathy (AION), the most common acute optic neuropathy in those older than 50 years of age. METHODS: We performed a cross-sectional study of 55 nonarteritic anterior ischemic optic neuropathy (NAION) eyes in 34 patients to assess clinical outcome and perform structure-function correlations. RESULTS: The peak age of NAION onset was between 50 and 55 years...
May 18, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28537732/rapid-flame-synthesis-of-atomically-thin-moo3-down-to-monolayer-thickness-for-effective-hole-doping-of-wse2
#6
Lili Cai, Connor J McClellan, Ai Leen Koh, Hong Li, Eilam Yalon, Eric Pop, Xiaolin Zheng
Two-dimensional (2D) molybdenum trioxide (MoO3) with mono- or few-layer thickness can potentially advance many applications, ranging from optoelectronics, catalysis, sensors, and batteries to electrochromic devices. Such ultrathin MoO3 sheets can also be integrated with other 2D materials (e.g., as dopants) to realize new or improved electronic devices. However, there is lack of a rapid and scalable method to controllably grow mono- or few-layer MoO3. Here, we report the first demonstration of using a rapid (<2 minutes) flame synthesis method to deposit mono- and few-layer MoO3 sheets (several microns in lateral dimension) on a wide variety of layered materials, including mica, MoS2, graphene and WSe2, based on van der Waals epitaxy...
May 24, 2017: Nano Letters
https://www.readbyqxmd.com/read/28537722/a-novel-micro-mea-design-to-precisely-measure-the-in-situ-activity-of-orr-electrocatalysts-for-pemfc
#7
Zhi Long, Yankai Li, Guangrong Deng, Changpeng Liu, Junjie Ge, Shuhua Ma, Wei Xing
An in-situ micro-MEA technique, which could precisely measure the performance of ORR electrocatalyst using Nafion as electrolyte, was designed and compared with regular thin-film rotating-disk electrode (TFRDE) (0.1 M HClO4) and normal in-situ membrane electrode assembly (MEA) tests. Compared to the traditional TFRDE method, the micro-MEA technique makes the acquisition of catalysts' behavior at low potential values easily achieved without being limited by the solubility of O2 in water. At the same time, it successfully mimics the structure of regular MEAs and obtains similar results to a regular MEA, thus providing a new technique to simply measure the electrode activity without being bothered by complicated fabrication of regular MEA...
May 24, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28535827/genotype-%C3%A3-environment-interaction-in-psychiatric-genetics-deep-truth-or-thin-ice
#8
Lindon Eaves
BACKGROUND: There continues to be significant investment in the detection of genotype × environment interaction (G × E) in psychiatric genetics. The implications of the method of assessment for the genetic analysis of psychiatric disorders are examined for simulated twin data on symptom scores and environmental covariates. METHODS: Additive and independent genetic and environmental risks were simulated for 10,000 monozygotic (MZ) and 10,000 dizygotic (DZ) twin pairs and the 'subjects' administered typical simulated checklists of clinical symptoms and environmental factors...
May 24, 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/28535078/complementation-of-ctb7-in-the-maize-pathogen-cercospora-zeina-overcomes-the-lack-of-in-vitro-cercosporin-production
#9
Velushka Swart, Bridget Genevieve Crampton, John Ridenour, Burton Bluhm, Nicholas Olivier, Marion Meyer, Dave Kenneth Berger
Gray leaf spot (GLS), caused by the sibling species Cercospora zeina or Cercospora zeae-maydis, is cited as one of the most important diseases threatening global maize production. C. zeina fails to produce cercosporin in vitro, and in most cases causes large coalescing lesions during maize infection; a symptom generally absent from cercosporin-deficient mutants in other Cercospora spp. Here we describe the C. zeina cercosporin toxin biosynthetic gene cluster. The oxidoreductase gene CTB7 contained several insertions and deletions as compared to the C...
May 23, 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/28535064/ten-fold-enhancement-of-inas-nanowire-photoluminescence-emission-with-an-inp-passivation-layer
#10
Pamela Jurczak, Yunyan Zhang, Jiang Wu, Ana M Sanchez, Martin Aagesen, Huiyun Liu
In this letter, we demonstrate that a significant improvement of optical performance of InAs nanowires can be achieved by capping the core InAs nanowires with a thin InP shell, which successfully passivates the surface states reducing the rate of non-radiative recombination. The improvements have been confirmed by detailed photoluminescence measurements, which showed up to ten-fold increase in the intensity of room-temperature photoluminescence from the capped InAs/InP nanowires compared to the sample with core-only InAs nanowires...
May 23, 2017: Nano Letters
https://www.readbyqxmd.com/read/28534919/solid-state-and-surface-effects-in-thin-film-molecular-switches
#11
Jonathan P Hopwood, Jacob W Ciszek
Thin-films of three dihydroindolizine molecular switches were monitored via polarization modulation infrared reflection absorption spectroscopy to quantify solid state and surface-based inhibition of switching as a function of irradiation time. In the solid state, the molecular switches diverged dramatically with flexible alkyl substituents resulting in switching rates up to three times that of switches containing rigid analogs. For thin-films, decreasing film thickness from 30 nm to approximately 4 molecules thick resulted in an increase in inhibition...
May 23, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28534907/inkjet-printed-highly-transparent-and-flexible-graphene-micro-supercapacitors
#12
Szymon Sollami Delekta, Anderson D Smith, Jiantong Li, Mikael Östling
Modern energy storage devices for portable and wearable technologies must fulfill a number of requirements, such as small size, flexibility, thinness, reliability, transparency, manufacturing simplicity and performance, in order to be competitive in an ever expanding market. To this end, a comprehensive inkjet printing process is developed for the scalable and low-cost fabrication of transparent and flexible micro-supercapacitors. These solid-state devices, with printed thin films of graphene flakes as interdigitated electrodes, exhibit excellent performance versus transparency (ranging from a single-electrode areal capacitance of 16 μF cm(-2) at transmittance of 90% to a capacitance of 99 μF cm(-2) at transmittance of 71%)...
May 23, 2017: Nanoscale
https://www.readbyqxmd.com/read/28534900/interplay-between-many-body-effects-and-coulomb-screening-in-the-optical-bandgap-of-atomically-thin-mos2
#13
Youngsin Park, Sang Wook Han, Christopher C S Chan, Benjamin P L Reid, Robert A Taylor, Nammee Kim, Yongcheol Jo, Hyunsik Im, Kwang S Kim
Due to its unique layer-number dependent electronic band structure and strong excitonic features, atomically thin MoS2 is an ideal 2D system where intriguing photoexcited-carrier-induced phenomena can be detected in excitonic luminescence. We perform micro-photoluminescence (PL) measurements and observe that the PL peak redshifts nonlinearly in mono- and bi-layer MoS2 as the excitation power is increased. The excited carrier-induced optical bandgap shrinkage is found to be proportional to n(4/3), where n is the optically-induced free carrier density...
May 23, 2017: Nanoscale
https://www.readbyqxmd.com/read/28534808/development-towards-compact-nitrocellulose-based-interferometric-biochips-for-dry-eye-mmp9-label-free-in-situ-diagnosis
#14
Beatriz Santamaría, María F Laguna, David López-Romero, Ana L Hernandez, Francisco J Sanza, Álvaro Lavín, Rafael Casquel, María V Maigler, Rocío L Espinosa, Miguel Holgado
A novel compact optical biochip based on a thin layer-sensing surface of nitrocellulose is used for in-situ label-free detection of metalloproteinase (MMP9) related to dry eye disease. In this article, a new integrated chip with different interferometric transducers layout with an optimal sensing surface is reported for the first time. We demonstrate that specific antibodies can be immobilized onto these transducers with a very low volume of sample and with good orientation. Many sensing transducers constitute the presented biochip in order to yield statistical data and stability in the acquired measurements...
May 19, 2017: Sensors
https://www.readbyqxmd.com/read/28534735/the-use-of-the-gaps-in-noise-test-as-an-index-of-the-enhanced-left-temporal-cortical-thinning-associated-with-the-transition-between-mild-cognitive-impairment-and-alzheimer-s-disease
#15
Vasiliki Vivian Iliadou, Doris-Eva Bamiou, Christos Sidiras, Nikolaos P Moschopoulos, Magda Tsolaki, Ioannis Nimatoudis, Gail D Chermak
BACKGROUND: The known link between auditory perception and cognition is often overlooked when testing for cognition. PURPOSE: To evaluate auditory perception in a group of older adults diagnosed with mild cognitive impairment (MCI). RESEARCH DESIGN: A cross-sectional study of auditory perception. STUDY SAMPLE: Adults with MCI and adults with no documented cognitive issues and matched hearing sensitivity and age. DATA COLLECTION: Auditory perception was evaluated in both groups, assessing for hearing sensitivity, speech in babble (SinB), and temporal resolution...
May 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28534675/gallium-in-depth-profile-in-bromine-etched-copper-indium-galium-di-selenide-cigs-thin-films-inspected-using-raman-spectroscopy
#16
Jacopo Parravicini, Maurizio Acciarri, Alberto Lomuscio, Matteo Murabito, Alessia Le Donne, Andrea Gasparotto, Simona Binetti
In the thin film solar cells domain, copper indium galium (di)selenide (CIGS) is a material with well-established photovoltaic purpose. Here the presence of a suitable [Ga]/([Ga]+[In]) (GGI) in-depth profile has proved to play a key role in the performance of cells. The implementation of a routine method based on reliable but easily available experimental techniques is mandatory to obtain information on the GGI profile of any CIGS layer, in order to achieve high efficiency chalcogenide layers. In this vein, we here propose and systematically test a simple method for the GGI profile determination based on repeated bromine etching of CIGS thin films followed by Raman analysis of the A1 peak position...
June 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28534674/accurate-molecular-orientation-analysis-using-infrared-p-polarized-multiple-angle-incidence-resolution-spectrometry-pmairs-considering-the-refractive-index-of-the-thin-film-sample
#17
Nobutaka Shioya, Takafumi Shimoaka, Richard Murdey, Takeshi Hasegawa
Infrared (IR) p-polarized multiple-angle incidence resolution spectrometry (pMAIRS) is a powerful tool for analyzing the molecular orientation in an organic thin film. In particular, pMAIRS works powerfully for a thin film with a highly rough surface irrespective of degree of the crystallinity. Recently, the optimal experimental condition has comprehensively been revealed, with which the accuracy of the analytical results has largely been improved. Regardless, some unresolved matters still remain. A structurally isotropic sample, for example, yields different peak intensities in the in-plane and out-of-plane spectra...
June 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28534636/annealing-induced-shape-transformation-of-czts-nanorods-based-thin-films
#18
Govind Rajesh, Natarajan Muthukumarasamy, Dhayalan Velauthapillai, Sudip Kumar K Batabyal
Here we studied the annealing induced shape transformation of 1-D Cu2ZnSnS4 (CZTS) nanorods from nanospheres and nanocubes by simple sol-gel method without using any toxic chemicals or complicated vacuum based technology. X-ray diffraction pattern and Raman Spectra reveals the formation of Kesterite structure CZTS thin films. The energy dispersive X-ray analysis results indicate the presence of Cu, Zn, Sn and S. The elemental distribution of all the CZTS samples was studied using elemental mapping. The Hall effect studies of the CZTS thin film composed of nanorods exhibits the lowest resistivity values which indicates efficient charge transfer for unidirectional structure...
May 23, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28534625/reaction-mechanisms-of-the-atomic-layer-deposition-of-tin-oxide-thin-films-using-tributyltin-ethoxide-and-ozone
#19
Charith E Nanayakkara, Guo Liu, Abraham Vega, Charles L Dezelah, Ravindra K Kanjolia, Yves J Chabal
Uniform and conformal deposition of tin oxide thin films is important for several applications in electronics, gas sensing and transparent conducting electrodes. Thermal Atomic layer deposition (ALD) is often best suited for these applications, but its implementation requires a mechanistic understanding of the initial nucleation and subsequent ALD processes. To this end, in-situ FTIR and ex-situ XPS have been used to explore the ALD of tin oxide films using tributyltin ethoxide and ozone on an OH-terminated, SiO2-passivated Si(111) substrate...
May 23, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28534623/young-s-modulus-of-wurtzite-and-zinc-blende-inp-nanowires
#20
Mikhail Dunaevskiy, Pavel Geydt, Erkki Lahderanta, Prokhor Anatolevich Alekseev, Tuomas August Erik Haggren, Joona-Pekko Petteri Kakko, Hua Jiang, Harri Lipsanen
The Young's modulus of thin conical InP nanowires with either wurtzite or mixed "zinc blende/wurtzite" structures was measured. It has been shown that the value of Young's modulus obtained for wurtzite InP nanowires (E[0001]=130 ± 30 GPa) was similar to the theoretically predicted value for the wurtzite InP material (E[0001]=120 ± 10 GPa). The Young's modulus of mixed "zinc blende/wurtzite" InP nanowires (E[111]=65 ± 10 GPa) appeared to be 40% less then theoretically predicted value for the zinc blende InP material (E[111]=110 GPa)...
May 23, 2017: Nano Letters
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