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https://www.readbyqxmd.com/read/29667286/molecular-vise-approach-to-create-metal-binding-sites-in-mofs-and-detection-of-biomarker
#1
Yang Wang, Qi Liu, Qin Zhang, Bosi Peng, Hexiang Deng
We report a new approach to create metal-binding site in a series of metal-organic frameworks (MOFs), where tetra-topic carboxylate linker, 4',4'',4''',4''''-methanetetrayltetrabiphenyl-4-carboxylic acid, is partially replaced by a tri-topic carbox-ylate linker, tris(4-carboxybiphenyl)amine, in combination with mono-topic linkers, formic acid, trifluoroacetic acid, ben-zoic acid, isonicotinic acid, 4-chlorobenzoic acid, and 4-nitrobenzoic acid, respectively. The distance between these paired-up linkers can be precisely controlled, ranging from 5...
April 18, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29667267/the-cerebellum-after-trauma-resting-state-functional-connectivity-of-the-cerebellum-in-posttraumatic-stress-disorder-and-its-dissociative-subtype
#2
Daniela Rabellino, Maria Densmore, Jean Théberge, Margaret C McKinnon, Ruth A Lanius
The cerebellum plays a key role not only in motor function but also in affect and cognition. Although several psychopathological disorders have been associated with overall cerebellar dysfunction, it remains unclear whether different regions of the cerebellum contribute uniquely to psychopathology. Accordingly, we compared seed-based resting-state functional connectivity of the anterior cerebellum (lobule IV-V), of the posterior cerebellum (Crus I), and of the anterior vermis across posttraumatic stress disorder (PTSD; n = 65), its dissociative subtype (PTSD + DS; n = 37), and non-trauma-exposed healthy controls (HC; n = 47)...
April 17, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29666582/a-novel-approach-to-primary-cell-culture-for-octopus-vulgaris-neurons
#3
Valeria Maselli, Fenglian Xu, Naweed I Syed, Gianluca Polese, Anna Di Cosmo
Octopus vulgaris is a unique model system for studying complex behaviors in animals. It has a large and centralized nervous system made up of lobes that are involved in controlling various sophisticated behaviors. As such, it may be considered as a model organism for untangling the neuronal mechanisms underlying behaviors-including learning and memory. However, despite considerable efforts, Octopus lags behind its other counterparts vis-à-vis its utility in deciphering the cellular, molecular and synaptic mechanisms underlying various behaviors...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29666400/the-corticosteroid-compounds-prednisolone-and-vamorolone-do-not-alter-the-nociception-phenotype-and-exacerbate-liver-injury-in-sickle-cell-mice
#4
Luis E F Almeida, Jesse M Damsker, Sarah Albani, Nina Afsar, Sayuri Kamimura, Drew Pratt, David E Kleiner, Martha Quezado, Heather Gordish-Dressman, Zenaide M N Quezado
Clinicians often hesitate prescribing corticosteroids to treat corticosteroid-responsive conditions in sickle cell disease (SCD) patients because their use can be associated with complications (increased hospital readmission, rebound pain, strokes, avascular necrosis, acute chest syndrome). Consequently, SCD patients may receive suboptimal treatment for corticosteroid-responsive conditions. We conducted a preclinical trial of dissociative (vamorolone) and conventional (prednisolone) corticosteroid compounds to evaluate their effects on nociception phenotype, inflammation, and organ dysfunction in SCD mice...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29666277/disparate-binding-kinetics-by-an-intrinsically-disordered-domain-enables-temporal-regulation-of-transcriptional-complex-formation
#5
Neil O Robertson, Ngaio C Smith, Athina Manakas, Mahiar Mahjoub, Gordon McDonald, Ann H Kwan, Jacqueline M Matthews
Intrinsically disordered regions are highly represented among mammalian transcription factors, where they often contribute to the formation of multiprotein complexes that regulate gene expression. An example of this occurs with LIM-homeodomain (LIM-HD) proteins in the developing spinal cord. The LIM-HD protein LHX3 and the LIM-HD cofactor LDB1 form a binary complex that gives rise to interneurons, whereas in adjacent cell populations, LHX3 and LDB1 form a rearranged ternary complex with the LIM-HD protein ISL1, resulting in motor neurons...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29666249/eif1-loop-2-interactions-with-met-trna-i-control-the-accuracy-of-start-codon-selection-by-the-scanning-preinitiation-complex
#6
Anil Thakur, Alan G Hinnebusch
The eukaryotic 43S preinitiation complex (PIC), bearing initiator methionyl transfer RNA (Met-tRNAi ) in a ternary complex (TC) with eukaryotic initiation factor 2 (eIF2)-GTP, scans the mRNA leader for an AUG codon in favorable context. AUG recognition evokes rearrangement from an open PIC conformation with TC in a "POUT " state to a closed conformation with TC more tightly bound in a "PIN " state. eIF1 binds to the 40S subunit and exerts a dual role of enhancing TC binding to the open PIC conformation while antagonizing the PIN state, necessitating eIF1 dissociation for start codon selection...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29666207/split-hand-muscle-echo-intensity-index-as-a-reliable-imaging-marker-for-differential-diagnosis-of-amyotrophic-lateral-sclerosis
#7
Hung Youl Seok, Jinseok Park, Yoo Hwan Kim, Ki-Wook Oh, Seung Hyun Kim, Byung-Jo Kim
OBJECTIVE: The objective of this study was to investigate the usefulness of muscle ultrasound in evaluating dissociated small hand muscle atrophy, termed 'split hand', and its feasibility in the diagnosis of amyotrophic lateral sclerosis (ALS). METHODS: Forty-four patients with ALS, 18 normal subjects and 9 patients with other neuromuscular disorders were included in this study. The hand muscles were divided into three regions, the median-innervated lateral hand muscle group (ML), the ulnar-innervated lateral hand muscle (UL) and the ulnar-innervated medial hand muscle (UM), and the muscle echo intensity (EI) and compound muscle action potential (CMAP) were measured...
April 17, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29666182/a-mechanism-for-differential-sorting-of-the-planar-cell-polarity-proteins-frizzled6-and-vangl2-at-the-trans-golgi-network
#8
Tianji Ma, Baiying Li, Ryan Wang, Pik Ki Lau, Yan Huang, Liwen Jiang, Randy Schekman, Yusong Guo
In planar cell polarity (PCP), the epithelial cells are polarized along the plane of the cell surface perpendicular to the classical apical-basal axis, a process mediated by several conserved signaling receptors. Two PCP-signaling proteins, VANGL planar cell-polarity protein 2 (Vangl2) and Frizzled6 (Fzd6), are located asymmetrically on opposite boundaries of the cell. Examining sorting of these two proteins at the trans-Golgi network (TGN), we demonstrated previously that the GTP-binding protein ADP ribosylation factor-related protein 1 (Arfrp1) and the clathrin adaptor complex 1 (AP-1) are required for Vangl2 transport from the TGN...
April 17, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29666167/a-flexible-mhc-class-i-multimer-loading-system-for-large-scale-detection-of-antigen-specific-t-cells
#9
Jolien J Luimstra, Malgorzata A Garstka, Marthe C J Roex, Anke Redeker, George M C Janssen, Peter A van Veelen, Ramon Arens, J H Frederik Falkenburg, Jacques Neefjes, Huib Ovaa
Adaptive immunity is initiated by T cell recognition of specific antigens presented by major histocompatibility complexes (MHCs). MHC multimer technology has been developed for the detection, isolation, and characterization of T cells in infection, autoimmunity, and cancer. Here, we present a simple, fast, flexible, and efficient method to generate many different MHC class I (MHC I) multimers in parallel using temperature-mediated peptide exchange. We designed conditional peptides for HLA-A*02:01 and H-2Kb that form stable peptide-MHC I complexes at low temperatures, but dissociate when exposed to a defined elevated temperature...
April 17, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29665679/can-the-electron-accepting-properties-of-odorants-be-involved-in-their-recognition-by-the-olfactory-system
#10
Stanislav Anatolievich Pshenichnyuk, Rustam Rakhmeyev, Nail Asfandiarov, Alexei S Komolov, Alberto Modelli, Derek Jones
The present study examines the possible importance of the electron-accepting properties of odorant molecules and, in particular, the formation and decay of temporary negative ions via low-energy electron attachment, as a possible contribution towards understanding odorant recognition by olfactory receptors (OR). Fragments formed by dissociative electron attachment (DEA) of mustard oil odorants represented by a series of isothiocyanates are studied experimentally using DEA spectroscopy and DFT calculations. Relative intensities for the most abundant fragment species, S- and SCN-, are found to be characteristic for structurally similar odorants under investigation...
April 17, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29665384/cryopreservation-of-sperm-bundles-spermatozeugmata-from-endangered-livebearing-goodeids
#11
Yue Liu, Leticia Torres, Terrence R Tiersch
More than half of fishes in the family Goodeidae are considered to be endangered, threatened, or vulnerable. Sperm cryopreservation is an effective tool for conserving genetic resources of imperiled populations, but development of protocols with livebearing fishes faces numerous challenges including the natural packaging of sperm into bundles. In this study the cryopreservation of sperm bundles (spermatozeugmata) of three goodeids species was evaluated. Sperm quality was evaluated by activation with NaCl-NaOH solution (at 300 mOsmol/kg and pH 11...
April 14, 2018: Cryobiology
https://www.readbyqxmd.com/read/29665293/multi-responsive-supramolecular-gels-based-on-charge-transfer-interactions
#12
Chen Li, Chengshuo Shen, Jiucheng Nie, Huibin Qiu
We report the co-assembly of aromatic donor (D) and acceptor (A) molecules into purple sponge-like supramolecular gels through susceptible charge transfer interactions with the aid of solvophobic interactions. The gel retained intact with the addition of up to 23% (v/v) of nonpolar good solvents, such as toluene and xylene, but dissociated in the presence of < 2% (v/v) of polar solvents, such as tetrahydrofuran, ethyl acetate, and alcohols, with highly distinguishable changes of color. Notably, the gel disappeared in 1 min and the solution turned blue when 0...
April 17, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29664615/non-competitive-effect-of-gambogic-acid-displaces-fluorescence-labelled-atp-but-requires-atp-for-binding-to-hsp90-htpg
#13
Qing Yue, Frank Stahl, Oliver Plettenburg, Andreas Kirschning, Athanasia Warnecke, Carsten Zeilinger
The heat shock protein 90 (Hsp90) family plays a critical role in maintaining the homeostasis of the intracellular environment for human and prokaryotic cells. Hsp90 were identified as important target proteins for cancer and plant disease therapies. It was shown that gambogic acid (GBA) has the potential to inhibit human Hsp90. However, it is unknown, whether it is also able to act on the bacterial high temperature protein (HtpG) analogue. In this work, we screened GBA and nine other novel potential Hsp90 inhibitors using a miniaturized high throughput protein microarray-based assay and found that GBA shows an inhibitory effect on different Hsp90s after dissimilarity analysis of the protein sequence alignment...
April 17, 2018: Biochemistry
https://www.readbyqxmd.com/read/29664414/enhanced-total-neurite-outgrowth-and-secondary-branching-in-dorsal-root-ganglion-neurons-elicited-by-low-intensity-pulsed-ultrasound
#14
Daniel Michael Ventre, Marissa Puzan, Emily Ashbolt, Abigail Koppes
OBJECTIVE: Despite the prevalence of peripheral nerve injuries (PNI), challenges remain in restoring full functionality to those afflicted. For recovery to occur, axons must extend across the injury site to connect with distal targets, where injury gap size is a critical factor in the probability of restoration of function. Current clinical therapies often achieve limited neural regeneration, motivating the development of new therapeutic interventions such as biophysical stimulation. APPROACH: To investigate the potential for low intensity, pulsed ultrasonic simulation (LIPUS) to impact peripheral nerve regeneration, primary neonatal rat dorsal root ganglion neurons were examined in vitro in response to ultrasound (US)...
April 17, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29664295/a-chemical-role-for-trichloromethane-room-temperature-removal-of-coordinated-solvents-from-open-metal-sites-in-the-copper-based-metal-organic-frameworks
#15
Jae Sun Choi, Jinhee Bae, Eun Ji Lee, Nak Cheon Jeong
Open coordination sites (OCSs) in metal-organic frameworks (MOFs) have shown potential in applications such as molecular separation, sorption, catalysis, and sensing. Thus, the removal of coordinated solvent has been viewed as an essential step that needs to be performed prior to the use of the MOFs in the above applications. To date, a thermal method that is normally performed by applying heat and vacuum has been the most commonly employed activation method despite its negative influence on the structural integrity of the MOFs...
April 17, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29664276/effects-of-n-n-dimethyltryptamine-dmt-on-rat-behaviors-relevant-to-anxiety-and-depression
#16
Lindsay P Cameron, Charlie J Benson, Lee E Dunlap, David E Olson
Depression and anxiety disorders are debilitating diseases resulting in substantial economic costs to society. Traditional antidepressants often take weeks to months to positively affect mood and are ineffective for about 30% of the population. Alternatives, such as ketamine, a dissociative anesthetic capable of producing hallucinations, and the psychoactive tisane ayahuasca have shown great promise due to their fast-acting nature and effectiveness in treatment-resistant populations. Here, we investigate the effects of N,N-dimethyltryptamine (DMT), the principle hallucinogenic component of ayahuasca, in rodent behavioral assays relevant to anxiety and depression using adult, male, Sprague-Dawley rats...
April 17, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29664204/characterization-and-epitope-mapping-of-a-panel-of-monoclonal-antibodies-against-hiv-1-matrix-protein
#17
Zhiqing Zhang, Feng Zhang, Shimeng Bai, Jiaming Qiao, Honglin Shen, Fang Huang, Shuangquan Gao, Shaowei Li, Ying Gu, Ningshao Xia
The HIV-1 Gag precursor protein (p55) is the main structural protein comprising the matrix (MA/p17), capsid (CA/p24), and nucleocapsid (NC/p7) proteins, and is uniquely responsible for virion assembly within the virus life cycle. The MA protein plays a critical role in plasma membrane targeting and envelope glycoprotein (Env) uptake during virion assembly. Yet, when viral infection occurs, the MA protein may also be involved in virion uncoating, dissociating from the plasma membrane, and participating in the nuclear importation process...
April 17, 2018: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/29663846/childhood-trauma-and-dissociative-intimate-partner-violence
#18
Aliya R Webermann, Christopher M Murphy
The present study assesses childhood abuse/neglect as a predictor of dissociative intimate partner violence (IPV) among 118 partner-abusive men. One third (36%) endorsed dissociative IPV, most commonly losing control (18%), surroundings seeming unreal (16%), feeling someone other than oneself is aggressing (16%), and seeing oneself from a distance aggressing (10%). Childhood physical abuse/neglect predicted IPV-specific derealization/depersonalization, aggressive self-states, and flashbacks to past violence...
April 1, 2018: Violence Against Women
https://www.readbyqxmd.com/read/29663675/a-stable-artificial-multienzymatic-complex-using-a-heterotrimeric-protein-from-metallosphaera-sedula
#19
Fumiya Iwata, Hidehiko Hirakawa, Teruyuki Nagamune
Bacterial cytochrome P450 monooxygenases (P450s) are promising biocatalysts for chemical syntheses because they catalyze a variety of oxidations on non-activated hydrocarbons using O2 . However, the requirement of two auxiliary proteins, an electron transfer protein and a reductase, for the catalysis is a major bottleneck for in vitro applications of these monooxygenases. Our previous study showed that artificial assembly of a bacterial P450 with its auxiliary proteins using a heterotrimeric proliferating cell nuclear antigen (PCNA) from Sulfolobus solfataricus yields a self-sufficient P450, but partial dissociation of P450 from the complex at catalytic concentrations reduces the apparent specific activity of this self-sufficient P450...
April 16, 2018: Biotechnology Journal
https://www.readbyqxmd.com/read/29663598/water-formation-below-silica-thin-films-real-time-observation-of-a-chemical-reaction-in-a-physically-confined-space
#20
Mauricio Javier Prieto, Hagen Klemm, Feng Xiong, Daniel Gottlob, Dietrich Menzel, Thomas Schmidt, Hans-Joachim Freund
Using low energy electron microscopy and local photoelectron spectroscopy, we investigated the water formation from adsorbed O and H₂ on a Ru(0001) surface covered with a vitreous SiO₂ bilayer (BL) and compared it to the same reaction on bare Ru(0001). In both cases the reaction is characterized by moving reaction fronts. The reason for this might be related with the requirement of site release by O adatoms for further H₂ dissociative adsorption. We find apparent activation energies (E_a^app) for the front motion of 0...
April 16, 2018: Angewandte Chemie
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