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https://www.readbyqxmd.com/read/29245112/spectroscopic-parameters-vibrational-levels-transition-dipole-moments-and-transition-probabilities-of-the-9-low-lying-states-of-the-ncl-cation
#1
Yuan Yin, Deheng Shi, Jinfeng Sun, Zunlue Zhu
This work calculates the potential energy curves of 9 Λ-S and 28Ω states of the NCl+ cation. The technique employed is the complete active space self-consistent field method, which is followed by the internally contracted multireference configuration interaction approach with the Davidson correction. The Λ-S states are X2Π, 12Σ+, 14Π, 14Σ+, 14Σ-, 24Π, 14Δ, 16Σ+, and 16Π, which are yielded from the first two dissociation channels of NCl+ cation. The Ω states are generated from these Λ-S states...
December 9, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29244904/pharmacokinetics-of-the-cannabinoid-receptor-ligand-18-f-mk-9470-in-the-rat-brain-evaluation-of-models-using-micropet
#2
Isabelle Miederer, Hans-Georg Buchholz, Andrea Kronfeld, Stephan Maus, Veronika Weyer-Elberich, Philipp Mildenberger, Beat Lutz, Mathias Schreckenberger
PURPOSE: The positron emission tomography ligand [18 F]MK-9470 is an inverse agonist that binds reversibly and with high affinity to the cannabinoid type 1 receptor. Due to its slow brain kinetics, care is required in the definition of its dissociation rates from the receptor. The goal of this study was to investigate pharmacokinetic analysis methods using an arterial input function. METHODS: Five Sprague-Dawley rats received injections of 13 to 25 MBq of [18 F]MK-9470 and were scanned over a period of 90 min...
December 15, 2017: Medical Physics
https://www.readbyqxmd.com/read/29244673/using-double-contrast-ct-arthrography-to-confirm-suspected-dissociation-of-a-cemented-polyethylene-liner-in-the-setting-of-revision-total-hip-arthroplasty-a-case-report
#3
Aakash Chauhan, Sean Fitzpatrick, Robert L Sciulli, Nicholas G Sotereanos, Jeffrey J Sewecke
CASE: A 67-year-old woman who underwent a re-revision of a total hip arthroplasty with a cemented polyethylene liner fell 14 months after surgery. The patient had symptoms of pain and weakness; however, clinical, laboratory, and radiographic evaluation did not disclose fracture, infection, osteolysis, or component migration. Liner dissociation was suspected, and a double-contrast computed tomography (CT) arthrogram confirmed failure at the cement-liner interface. She underwent additional revision surgery and was doing well at the 3-year follow-up...
April 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29243854/a-coordination-chemistry-approach-to-fine-tune-the-physicochemical-parameters-of-lanthanide-complexes-relevant-to-medical-applications
#4
Mariane Le Fur, Enikő Molnár, Maryline Beyler, Ferenc K Kálmán, Olivier Fougère, David Esteban-Gómez, Olivier Rousseaux, Raphaël Tripier, Gyula Tircsó, C Platas-Iglesias
The geometric features of two pyclen-based ligands possessing identical donor atoms but different site organization have a profound impact in their complexation properties toward lanthanide ions. The ligand containing two acetate groups and a picolinate arm arranged in a symmetrical fashion (L1) forms a Gd3+ complex being two orders of magnitude less stable than its dissymmetric analogue GdL2. Besides, GdL1 experiences a much faster dissociation following the acid-catalyzed mechanism than GdL2. On the contrary, GdL1 exhibits a lower exchange rate of the coordinated water molecule compared to GdL2...
December 15, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29243754/recycling-of-zincite-zno-via-uptake-of-hydrogen-halides
#5
Oday H Ahmed, Mohammednoor Altarawneh, Mohammad Al-Harahsheh, Zhong-Tao Jiang, Bogdan Z Dlugogorski
Hydrogen halides (HCl/HBr) represent major halogen fragments from the thermal decomposition of halogen laden materials, most notably PVC and brominated flame retardants (BFRs). Co-pyrolysis of halogen-containing solid waste with metal oxides is currently deployed as a mainstream strategy to treat halogen content as well as to recycle the valuable metallic fraction embedded in electric arc furnace dust (EAFD) and e-waste. However, designing an industrial-scale recycling facility necessitates accurate knowledge on mechanistic and thermo-kinetic parameters dictating the interaction between metal oxides and hydrogen halides...
December 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29243559/multiplicity-and-mutuality-in-the-transition-of-patient-and-therapist-s-self-states-comparison-of-good-vs-poor-outcome-groups
#6
Nehama Hacohen, Dana Atzil-Slonim, Rivka Tuval-Mashiach, Eran Bar-Kalifa, Hadar Fisher
OBJECTIVE: According to the Assimilation Model, the self is consisted of multiple internal voices which are sometimes conflicted, or even dissociated, from one another. Thus, a key therapeutic goal is to create awareness and dialogue between a patient's various internal voices, in order to facilitate positive change. A recent development of this theoretical line suggests that clinically addressing both the patients' and therapists' internal voices, and their mutual influences, contributes significantly to the treatment outcome...
December 15, 2017: Psychotherapy Research: Journal of the Society for Psychotherapy Research
https://www.readbyqxmd.com/read/29243518/synaesthesia-is-linked-to-more-vivid-and-detailed-content-of-autobiographical-memories-and-less-fading-of-childhood-memories
#7
Taylor Chin, Jamie Ward
People with synaesthesia have enhanced memory on a wide range of laboratory tests of episodic memory, but very little is known about their real-world memory. This study used a standard measure of autobiographical remembering (the Autobiographical Memory Questionnaire, AMQ) considering four constructs (Recollection, Belief, Impact and Rehearsal) and two time periods (recent memories from adulthood, remote memories from childhood). Synaesthetes reported more Recollection (e.g., sensory detail) and Belief (e.g...
December 15, 2017: Memory
https://www.readbyqxmd.com/read/29243511/acute-stress-disorder-and-c-reactive-protein-in-patients-with-acute-myocardial-infarction
#8
Hannes Bielas, Rebecca E Meister-Langraf, Jean-Paul Schmid, Jürgen Barth, Hansjörg Znoj, Ulrich Schnyder, Mary Princip, Roland von Känel
Background Myocardial infarction-triggered acute stress disorder (ASD) and subclinical inflammation associate with the development of posttraumatic stress disorder, and worsen the prognosis of myocardial infarction patients. We examined the relationship between ASD severity and C-reactive protein levels in patients with acute myocardial infarction. Methods We assessed 190 patients (median age 59 years; 83% men) with a verified myocardial infarction within 48 h of an acute coronary intervention. Circulating levels of C-reactive protein were categorized according to their prognostic risk for cardiovascular disease: 0 to <5, 5 to <10, 10 to <20, and ≥ 20 mg/l...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29243480/reshaping-the-energy-landscape-transforms-the-mechanism-and-binding-kinetics-of-dna-threading-intercalation
#9
Andrew G Clark, M Nabuan Naufer, Fredrik Westerlund, Per Lincoln, Ioulia Rouzina, Thayaparan Paramanathan, Mark C Williams
Molecules that bind DNA via threading intercalation show high binding affinity as well as slow dissociation kinetics, properties ideal for the development of anticancer drugs. To this end, it is critical to identify the specific molecular characteristics of threading intercalators that result in optimal DNA interactions. Using single molecule techniques, we quantify the binding of a small metalorganic ruthenium threading intercalator (Δ,Δ-B), and compare its binding characteristics to a similar molecule with significantly larger threading moieties (Δ,Δ-P)...
December 15, 2017: Biochemistry
https://www.readbyqxmd.com/read/29243370/neurological-nutritional-and-alcohol-consumption-factors-underlie-cognitive-and-motor-deficits-in-chronic-alcoholism
#10
Rosemary Fama, Anne-Pascale Le Berre, Cheshire Hardcastle, Stephanie A Sassoon, Adolf Pfefferbaum, Edith V Sullivan, Natalie M Zahr
Variations in pattern and extent of cognitive and motor impairment occur in alcoholism (ALC). Causes of such heterogeneity are elusive and inconsistently accounted for by demographic or alcohol consumption differences. We examined neurological and nutritional factors as possible contributors to heterogeneity in impairment. Participants with ALC (n = 96) and a normal comparison group (n = 41) were examined on six cognitive and motor domains. Signs of historically determined subclinical Wernicke's encephalopathy were detected using the Caine et al...
December 15, 2017: Addiction Biology
https://www.readbyqxmd.com/read/29243314/a-self-repaired-cathode-material-for-lithium-selenium-battery-se-c-chemically-bonded-selenium-graphene-composite
#11
Linna Sha, Peng Gao, Xiaochen Ren, Yurong Yang, Yujin Chen, Piaoping Yang
Lithium-Selenium battery, using selenium as cathode material, has exhibited specially superior advantages, such as better discharging rate and cycling performance due to its high electrical conductivity, higher output voltages and the corresponding higher volumetric capacity density. However, an important problem, named as "shuttle effect", presiding over the capacity decaying exists in Li-Se cells (also in Li-S cells) due to an aggregation and an immigration of Se or S from cathode into electrolyte. In this work, in order to solve the above problem, a new self-repaired system has been provided, in which some Se atoms are chemically bonded with carbon atoms of graphene and act as the reclaiming points for dissociative Se atoms with a -Se-Se-Se- chain style...
December 15, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29243175/survival-of-the-drowsiest-the-hibernating-100s-ribosome-in-bacterial-stress-management
#12
REVIEW
David W Gohara, Mee-Ngan F Yap
In response to nutrient deprivation and environmental insults, bacteria conjoin two copies of non-translating 70S ribosomes that form the translationally inactive 100S dimer. This widespread phenomenon is believed to prevent ribosome turnover and serves as a reservoir that, when conditions become favorable, allows the hibernating ribosomes to be disassembled and recycled for translation. New structural studies have revealed two distinct mechanisms for dimerizing 70S ribosomes, but the molecular basis of the disassembly process is still in its infancy...
December 14, 2017: Current Genetics
https://www.readbyqxmd.com/read/29242985/increasing-risk-of-psychiatric-morbidity-after-childhood-onset-type-1-diabetes-a-population-based-cohort-study
#13
Daniel Dybdal, Janne S Tolstrup, Stine M Sildorf, Kirsten A Boisen, Jannet Svensson, Anne Mette Skovgaard, Grete K Teilmann
AIMS/HYPOTHESIS: The aim of this study was to investigate psychiatric morbidity following childhood onset of type 1 diabetes. METHODS: In a matched, population-based cohort study based on Danish national registers, we identified children and adolescents who had been diagnosed as an in- or outpatient with type 1 diabetes before the age of 18, and afterwards diagnosed with a psychiatric disorder (n = 5084). Control individuals were matched according to sex and date of birth (n = 35,588)...
December 14, 2017: Diabetologia
https://www.readbyqxmd.com/read/29242301/in-vitro-and-in-vivo-evidence-for-uncoupling-of-bcr-internalization-and-signaling-in-chronic-lymphocytic-leukemia
#14
Eve M Coulter, Andrea Pepper, Silvia Mele, Najeem'deen Folarin, William Townsend, Kirsty Cuthill, Elizabeth Phillips, Piers Patten, Stephen Devereux
B-cell receptor activation, occurring within lymph nodes, plays a key role in the pathogenesis of chronic lymphocytic leukemia and is linked to prognosis. As well as activation of downstream signaling, receptor ligation triggers internalization, transit to acidified endosomes and degradation of ligand-receptor complexes. In the present study we investigated the relationship between these two processes in normal and leukemic B-cells. We found that leukemic B-cells, particularly anergic cases lacking the capacity to initiate downstream signaling, internalize and accumulate ligand in acidified endosomes more efficiently than normal B-cells...
December 14, 2017: Haematologica
https://www.readbyqxmd.com/read/29242148/whole-bacterium-selex-of-dna-aptamers-for-rapid-detection-of-e-coli-o157-h7-using-a-qcm-sensor
#15
Xiaofan Yu, Fang Chen, Ronghui Wang, Yanbin Li
The rapid detection of foodborne pathogens is critical to ensure food safety. The objective of this study is to select aptamers specifically bound to Escherichia coli O157:H7 using the whole-bacterium SELEX (Systematic Evolution of Ligands by Exponential Enrichment) and apply the selected aptamer to a QCM (quartz crystal microbalance) sensor for rapid and sensitive detection of target bacteria. A total of 19 rounds of selection against live E. coli O157:H7 and 6 rounds of counter selection against a mixture of Staphylococcus aureus, Listeria monocytogenes, and Salmonella Typhimurium, were performed...
December 12, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/29241981/uptake-of-iron-iii-ethylenediamine-n-n-n-n-tetraacetic-acid-complex-by-phosphatidylcholine-lipid-film-part-ii-effect-of-film-curvature
#16
Masumi Villeneuve, Mihoko Tanaka, Natsumi Saito, Hiroyasu Sakamoto, Yoshiteru Hayami
Mixed micelles formed in a ternary-solute aqueous solution of NaOH, iron (III)-ethylenediamine-N,N,N',N'-tetraacetic acid complex (Fe-edta) and 1,2-diheptanoyl-sn-glycero-3-phosphatidyl choline (DHPC) were studied and compared with the mixed adsorbed film reported in Part I of this series to clarify the effect of the curvature of molecular assemblies on the interactions between their Fe-edta and DHPC constituents. The critical micelle concentrations (CMCs), surface tension at the CMC, and solution pH were measured as functions of the mole fractions of NaOH and DHPC...
December 11, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/29241908/laboratory-and-clinical-significance-of-macroprolactinemia-in-women-with-hyperprolactinemia
#17
REVIEW
Miro Kasum, Slavko Orešković, Ermin Čehić, Martina Šunj, Albert Lila, Emina Ejubović
The role of macroprolactinemia in women with hyperprolactinemia is currently controversial and can lead to clinical dilemmas, depending upon the origin of macroprolactin, the presence of hyperprolactinemic symptoms and monomeric prolactin (PRL) levels. Macroprolactinemia is mostly considered an extrapituitary phenomenon of mild and asymptomatic hyperprolactinemia associated with normal concentrations of monomeric PRL and a predominance of macroprolactin confined to the vascular system, which is biologically inactive...
December 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29241651/distinct-roles-of-prelimbic-and-infralimbic-probdnf-in-extinction-of-conditioned-fear
#18
Wei Sun, Xiaoliang Li, Lei An
Brain-derived neurotrophic factor (BDNF) has been investigated for its positive role in regulation of fear acquisition and memory. The precursor of BDNF, proBDNF, has been identified as different protein from its mature form. The prelimbic (PL) and infralimbic (IL) sub-regions of the medial prefrontal cortex (mPFC) are functionally distinct in fear behavior. However, the role of PL and IL proBDNF in fear memory is unclear. Here, through the infusion of cleavage-resistant proBDNF and its antibody, we identified the dissociable roles of PL and IL proBDNF in fear expression and extinction memory as well as explored proBDNF's potential mechanism of action...
December 11, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29241649/the-structure-of-the-mental-lexicon-what-primary-progressive-aphasias-reveal
#19
Clara Sanches, Alexandre Routier, Olivier Colliot, Marc Teichmann
Like recursive syntax, a structured mental lexicon is specific to the human species but its internal organization remains unclear. It is thought to contain information about the semantic, syntactic (e.g., gender) and formal (orthographic/phonological) features of a word. Previous studies suggested that these three components might be separated at the behavioral level and that they might be implemented by temporal cortices. However, the available investigations are based on case reports or small-cohort studies with patients demonstrating post-stroke aphasia, and they did not contrast the three lexical components in a directly comparable way...
December 11, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29241548/diverging-mrna-and-protein-networks-in-activated-microglia-reveal-srsf3-suppresses-translation-of-highly-upregulated-innate-immune-transcripts
#20
Hejer Boutej, Reza Rahimian, Sai Sampath Thammisetty, Louis-Charles Béland, Mélanie Lalancette-Hébert, Jasna Kriz
Uncontrolled microglial activation may lead to the development of inflammation-induced brain damage. Here, we uncover a ribosome-based mechanism/checkpoint involved in control of the innate immune response and microglial activation. Using an in vivo model system for analysis of the dynamic translational state of microglial ribosomes, with mRNAs as input and newly synthesized peptides as an output, we find a marked dissociation of microglia mRNA and protein networks following innate immune challenge. Highly upregulated and ribosome-associated mRNAs were not translated, resulting in two distinct microglial molecular signatures, a highly specialized pro-inflammatory mRNA signature and an immunomodulatory/homeostatic protein signature...
December 12, 2017: Cell Reports
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