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https://www.readbyqxmd.com/read/28340419/photolytic-degradation-of-the-%C3%AE-blocker-nebivolol-in-aqueous-solution
#1
Alaa Salma, Holger V Lutze, Torsten C Schmidt, Jochen Tuerk
Nebivolol (NEB) is one of the top-sold prescription drugs belonging to the third generation of beta-blockers. However, so far, occurrence data in the environment are lacking. Within this study NEB has been found for the first time in effluent samples of wastewater treatment plants in Germany with an average concentration of 13 ng L(-1). Its photodegradation behavior in the environment and in technical processes is largely unknown. To fill this gap, three different UV treatment procedures (UV-C at 254 nm, UV-B at 312 nm and UV-A at 365 nm) were investigated in three different matrices: pure water, pure water in presence of the hydroxyl radical (OH) scavenger tert...
March 13, 2017: Water Research
https://www.readbyqxmd.com/read/28340114/the-pain-related-cognitive-processes-questionnaire-development-and-validation
#2
Melissa A Day, L Charles Ward, Beverly E Thorn, Cathryne P Lang, Toby R O Newton-John, Dawn M Ehde, Mark P Jensen
Objective.:  Cognitive processes may be characterized as how individuals think, whereas cognitive content constitutes what individuals think. Both cognitive processes and cognitive content are theorized to play important roles in chronic pain adjustment, and treatments have been developed to target both. However, the evaluation of treatments that target cognitive processes is limited because extant measures do not satisfactorily separate cognitive process from cognitive content. The current study aimed to develop a self-report inventory of potentially adaptive and presumed maladaptive attentional processes that may occur when someone is experiencing pain...
March 6, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28339399/early-huntington-s-disease-impulse-control-deficits-but-correct-judgment-regarding-risky-situations
#3
Victor Galvez, Juan Fernandez-Ruiz, Leo Bayliss, Adriana Ochoa-Morales, Carlos R Hernandez-Castillo, Rosalinda Díaz, Aurelio Campos-Romo
BACKGROUND: Huntington's disease (HD) patients show alterations in decision making tasks. However, it is still uncertain if these deficits are due to poor judgment regarding risky situations, or to impulse control deficits. OBJECTIVE: To elucidate whether decision-making in patients is related to genuine risk behavior or to impulse control deficits. METHODS: To test between these two alternative possibilities, we evaluated the performance of 19 prodromal HD patients and 19 matched healthy controls in the Cambridge Gambling Task (CGT)...
March 21, 2017: Journal of Huntington's Disease
https://www.readbyqxmd.com/read/28339326/using-online-methods-to-develop-and-examine-the-hong-kong-chinese-translation-of-the-dissociative-experiences-scale
#4
Chitat Chan, Hong Wang Fung, Tat Ming Choi, Colin A Ross
Identifying dissociation is important for mental health services because it could fundamentally affect one's diagnosis and treatment plan. The Dissociative Experiences Scale (DES) is a widely-used self-report scale for measuring dissociative experiences. It has been translated into many languages and used in many countries. However, there is no validated Hong Kong Chinese version of the DES available in the field, and there is no other validated Hong Kong Chinese instrument for assessing dissociative disorders...
March 24, 2017: Journal of Evidence-informed Social Work
https://www.readbyqxmd.com/read/28335324/dna-origami-reorganizes-upon-interaction-with-graphite-implications-for-high-resolution-dna-directed-protein-patterning
#5
Masudur Rahman, David Neff, Nathaniel Green, Michael L Norton
Although there is a long history of the study of the interaction of DNA with carbon surfaces, limited information exists regarding the interaction of complex DNA-based nanostructures with the important material graphite, which is closely related to graphene. In view of the capacity of DNA to direct the assembly of proteins and optical and electronic nanoparticles, the potential for combining DNA-based materials with graphite, which is an ultra-flat, conductive carbon substrate, requires evaluation. A series of imaging studies utilizing Atomic Force Microscopy has been applied in order to provide a unified picture of this important interaction of structured DNA and graphite...
October 31, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335002/handcuffing-reversal-is-facilitated-by-proteases-and-replication-initiator-monomers
#6
Katarzyna Bury, Katarzyna Wegrzyn, Igor Konieczny
Specific nucleoprotein complexes are formed strictly to prevent over-initiation of DNA replication. An example of those is the so-called handcuff complex, in which two plasmid molecules are coupled together with plasmid-encoded replication initiation protein (Rep). In this work, we elucidate the mechanism of the handcuff complex disruption. In vitro tests, including dissociation progress analysis, demonstrate that the dimeric variants of plasmid RK2 replication initiation protein TrfA are involved in assembling the plasmid handcuff complex which, as we found, reveals high stability...
March 9, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28334870/annealing-helicase-harp-closes-rpa-stabilized-dna-bubbles-non-processively
#7
Daniel R Burnham, Bas Nijholt, Iwijn De Vlaminck, Jinhua Quan, Timur Yusufzai, Cees Dekker
We investigate the mechanistic nature of the Snf2 family protein HARP, mutations of which are responsible for Schimke immuno-osseous dysplasia. Using a single-molecule magnetic tweezers assay, we construct RPA-stabilized DNA bubbles within torsionally constrained DNA to investigate the annealing action of HARP on a physiologically relevant substrate. We find that HARP closes RPA-stabilized bubbles in a slow reaction, taking on the order of tens of minutes for ∼600 bp of DNA to be re-annealed. The data indicate that DNA re-anneals through the removal of RPA, which is observed as clear steps in the bubble-closing traces...
February 28, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28334833/chip-seq-analysis-of-the-luxr-type-regulator-vjbr-reveals-novel-insights-into-the-brucella-virulence-gene-expression-network
#8
Claudia L Kleinman, Gabriela Sycz, Hernán R Bonomi, Romina M Rodríguez, Angeles Zorreguieta, Rodrigo Sieira
LuxR-type transcription factors control diverse physiological functions necessary for bacterial adaptation to environmental changes. In the intracellular pathogen Brucella, the LuxR homolog VjbR has been shown to regulate the expression of virulence factors acting at early stages of the intracellular infection and, directly or indirectly, hundreds of additional genes. However, the precise determination of VjbR direct targets has so far proved elusive. Here, we performed chromatin immunoprecipitation of VjbR followed by next-generation sequencing (ChIP-seq)...
March 11, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28334005/multi-scale-model-of-drug-induced-adaptive-resistance-of-gram-negative-bacteria-to-polymyxin-b
#9
Wojciech Krzyzanski, Gauri G Rao
The purpose of this report is to apply multi-scale modeling using the theory of physiologically structured populations (PSP) to develop a mathematical model for antimicrobial resistance based on a heterogeneous distribution of receptors and affinities among bacterial cells. The theory has been tested on data obtained from an in vitro static time-kill infection model analyzing the pharmacodynamics of polymyxin B against Gram-negative bacteria. The drug binding parameter KD (dissociation equilibrium constant) is assumed to vary between the bacterial cells...
2017: PloS One
https://www.readbyqxmd.com/read/28333525/a-potential-psychological-mechanism-linking-disaster-related-prenatal-maternal-stress-with-child-cognitive-and-motor-development-at-16-months-the-qf2011-queensland-flood-study
#10
Katrina M Moss, Gabrielle Simcock, Vanessa Cobham, Sue Kildea, Guillaume Elgbeili, David P Laplante, Suzanne King
Fetal exposure to prenatal maternal stress can have lifelong consequences, with different types of maternal stress associated with different areas of child development. Fewer studies have focused on motor skills, even though they are strongly predictive of later development across a range of domains. Research on mechanisms of transmission has identified biological cascades of stress reactions, yet links between psychological stress reactions are rarely studied. This study investigates the relationship between different aspects of disaster-related prenatal maternal stress and child cognitive and motor development, and proposes a cascade of stress reactions as a potential mechanism of transmission...
April 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28333494/taxonomic-and-thematic-semantic-systems
#11
Daniel Mirman, Jon-Frederick Landrigan, Allison E Britt
Object concepts are critical for nearly all aspects of human cognition, from perception tasks like object recognition, to understanding and producing language, to making meaningful actions. Concepts can have 2 very different kinds of relations: similarity relations based on shared features (e.g., dog-bear), which are called "taxonomic" relations, and contiguity relations based on co-occurrence in events or scenarios (e.g., dog-leash), which are called "thematic" relations. Here, we report a systematic review of experimental psychology and cognitive neuroscience evidence of this distinction in the structure of semantic memory...
March 23, 2017: Psychological Bulletin
https://www.readbyqxmd.com/read/28333492/perceptual-and-memory-inhibition-deficits-in-clinically-healthy-older-adults-are-associated-with-region-specific-doubly-dissociable-patterns-of-cortical-thinning
#12
Teal S Eich, Qolamreza R Razlighi, Yaakov Stern
Converging evidence suggests that the cognitive control processes that enable the inhibition of irrelevant information on a perceptual versus a memorial basis are qualitatively different and are underlain by unique neural systems that may be affected differentially in aging. In the current study, we investigated whether individual differences in performance on these 2 types of inhibitory processes were attributable to region-specific patterns of cortical thinning. Clinically healthy older adults completed a pair of behavioral memory and perceptual inhibition tasks and then underwent structural brain imaging...
March 23, 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28333434/measurement-of-in-vivo-protein-binding-affinities-in-a-signaling-network-with-mass-spectrometry
#13
Mumun Gencoglu, Alexander Schmidt, Attila Becskei
Protein interaction networks play a key role in signal processing. Despite the progress in identifying the interactions, the quantification of their strengths lags behind. Here we present an approach to quantify the in vivo binding of proteins to their binding partners in signaling-transcriptional networks, by the pairwise genetic isolation of each interaction and by varying the concentration of the interacting components over time. The absolute quantification of the protein concentrations was performed with targeted mass spectrometry...
March 23, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28333270/environmental-and-genetic-modulation-of-the-phenotypic-expression-of-antibiotic-resistance
#14
Diarmaid Hughes, Dan I Andersson
Antibiotic resistance can be acquired by mutation or horizontal transfer of a resistance gene, and generally an acquired mechanism results in a predictable increase in phenotypic resistance. However, recent findings suggest that the environment and/or the genetic context can modify the phenotypic expression of specific resistance genes/mutations. An important implication from these findings is that a given genotype does not always result in the expected phenotype. This dissociation of genotype and phenotype has important consequences for clinical bacteriology and for our ability to predict resistance phenotypes from genetics and DNA sequences...
March 8, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28332952/dying-for-love-an-attachment-problem-with-some-perpetrator-introjects
#15
Valerie Sinason
This paper focuses on some problematic victim-perpetrator dynamics in psychotherapy with patients with Dissociative Identity Disorder where there has been longstanding multi-perpetrator organized abuse described, which also involves family members. Additionally, in this specific sample, there have been reported experiences of serious assaults from attachment figures in which the patient felt close to death. The clinical concern is expressed that only in the nearness of death is a connection felt to the attachment figure and this leads to extra suicidality in the patient and extra vulnerability to secondary traumatization for the therapist...
March 1, 2017: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/28332820/kinetic-landscape-of-a-peptide-bond-forming-prolyl-oligopeptidase
#16
Clarissa Melo Czekster, James H Naismith
Prolyl oligopeptidase B from Galerina marginata (GmPOPB) has recently been discovered as a peptidase capable of breaking and forming peptide bonds to yield a cyclic peptide. Despite the relevance of prolyl oligopeptidases in human biology and disease, a kinetic analysis pinpointing rate-limiting steps for a member of this enzyme family is not available. Macrocyclase enzymes are currently exploited to produce cyclic peptides with potential therapeutic applications. Cyclic peptides are promising drug-like molecules due to their stability and conformational rigidity...
March 23, 2017: Biochemistry
https://www.readbyqxmd.com/read/28332394/impact-of-interfacial-defects-on-the-properties-of-monolayer-transition-metal-dichalcogenide-lateral-heterojunctions
#17
Zhen Cao, Moussab Harb, Sheikha Lardhi, Luigi Cavallo
We explored the impact of interfacial defects on the stability and optoelectronic properties of monolayer transition metal dichalcogenides lateral heterojunction using a DFT approach. As prototype, we focused on MoS2-WSe2, and we found that even a random alloy-like interface, within a width of 1 nm, has minimal impact on the band gap and alignment compared to defect-less interfaces. The largest impact is on the evolution of the total local potential energy across the monolayer. Similarly to defect-less interfaces, small amount of defects results in a potential energy profile with a sharp change at the interface, which facilitates exciton dissociation...
March 23, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28332377/hb-heathrow-%C3%AE-103-g5-phe%C3%A2-leu-a-first-report-in-an-asian-patient-with-erythrocytosis
#18
Sang Yong Shin, Hyun Young Kim, Hee Jin Kim, Hoon Gu Kim
Congenital erythrocytosis (CE) is a rare and heterogeneous disease. The high oxygen affinity hemoglobin (Hb) variants are the most common cause of CE. Herein, we report a Korean patient with isolated erythrocytosis. A 25-year-old man was referred to our hospital for evaluation of high Hb level (Hb 20.4 g/dL, hematocrit 58%, reticulocyte count 2.90%, white blood cell count 6.83×10⁹/L, and platelet count 195×10⁹/L). Bone marrow biopsy revealed normocellular marrow without myeloproliferative features. JAK2 (V617F, exon 12), CALR (exon 9), and MPL W515K/L mutations were not detected...
May 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28332282/chirally-sensitive-collision-induced-dissociation-of-proton-bound-diastereomeric-complexes-of-tryptophan-and-2-butanol
#19
Oleksii Rebrov, Kostiantyn Kulyk, Mauritz Ryding, Richard D Thomas, Einar Uggerud, Mats Larsson
In this work we report the stereo-dependent collision-induced dissociation (CID) of proton-bound complexes of tryptophan and 2-butanol. The dissociation efficiency was measured as a function of collision energy in single collision mode. The homochiral complex was found to be less stable against CID than a heterochiral one. Additional gas dependence measurements were performed with diastereomeric complexes that confirm the findings.
March 23, 2017: Chirality
https://www.readbyqxmd.com/read/28332205/evidence-that-5-ht-stimulates-intracellular-ca-2-signalling-and-activates-pannexin-1-currents-in-type-ii-cells-of-the-rat-carotid-body
#20
Sindhubarathi Murali, Min Zhang, Colin A Nurse
Carotid body (CB) chemoreceptor (type I) cells can synthesize and release 5-hydroxytryptamine (5-HT) and increased autocrine-paracrine 5-HT2 receptor signalling contributes to sensory long-term facilitation during chronic intermittent hypoxia (CIH). However, recent studies suggest that adjacent glial-like type II cells can respond to CB paracrine signals by elevating intracellular calcium (Δ[Ca(2+) ]i ) and activating carbenoxolone-sensitive, ATP-permeable, pannexin-1 (Panx-1)-like channels. Here, using dissociated rat CB cultures, we found that 5-HT induced Δ[Ca(2+) ]i responses in a subpopulation of type I cells, and in most (∼67%) type II cells identified by their sensitivity to the P2Y2 receptor agonist, UTP...
March 22, 2017: Journal of Physiology
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