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https://www.readbyqxmd.com/read/29912728/muscle-pain-syndromes-and-fibromyalgia-the-role-of-muscle-biopsy
#1
Lucia Ruggiero, Fiore Manganelli, Lucio Santoro
PURPOSE OF REVIEW: Muscle pain syndromes are extremely frequent cause of chronic disability, and a muscle biopsy is often performed to achieve a diagnosis when myalgia has a myopatic origin. Instead, the role of muscle biopsy in fibromyalgia is controversial. This review examines the reported studies with the objective to evaluate if some changes exist in the muscle, if these changes produce pain and if muscle biopsy is helpful in diagnostic flowchart of fibromyalgia. RECENT FINDINGS: Recent studies focused on functional side (muscle metabolism and the altered expression of proteins) hypothesize the role of peripheral factors in the maintenance of chronic pain...
June 15, 2018: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/29912727/ultrasound-imaging-for-sarcopenia-spasticity-and-painful-muscle-syndromes
#2
Levent Özçakar, Ayşe Merve Ata, Bayram Kaymak, Murat Kara, Dinesh Kumbhare
PURPOSE OF REVIEW: On the basis of its various advantages and the relevant awareness of physicians, ultrasound imaging has overwhelmingly taken its place in the scientific arena. This is true both from the side of daily clinical applications and also from the side of research. Yet, ultrasound provides real-time (diagnostic) imaging and (interventional) guidance for a wide spectrum of muscle disorders. In this regard, this review aims to discuss the potential/actual utility of ultrasound imaging in particular muscle disorders, that is, sarcopenia, spasticity and fibromyalgia/myofascial pain syndrome...
June 15, 2018: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/29911684/insurance-companies-fighting-the-peer-review-empire-without-any-validity-the-case-for-addiction-and-pain-modalities-in-the-face-of-an-american-drug-epidemic
#3
K Blum, W Jacobs, E J Modestino, N DiNubile, D Baron, T McLaughlin, D Siwicki, I Elman, M Moran, E R Braverman, P K Thanos, R D Badgaiyan
The United States are amid an opioid overdose epidemic; we are challenged to provide non-addicting/non-pharmacological alternatives to assist in pain attenuation. There are proven strategies available to manage chronic pain effectively without opioids. Utilization review providers for insurance companies often ignore medicine based scientific peer-reviewed studies that warn against the chronic use of opioid medications, as well as the lack of evidence to support long-term use of opioids for pain. This paradigm must change if we are to indeed change the drug-embracing culture in American chronic pain management...
October 4, 2018: SEJ Surg Pain
https://www.readbyqxmd.com/read/29911653/cognitive-behaviour-therapy-in-women-with-fibromyalgia-a-randomized-clinical-trial
#4
Bo Karlsson, Gunilla Burell, Ulla-Maria Anderberg, Kurt Svärdsudd
Background and aims Stress has been pointed out as an important influential factor in the development and maintaining of the fibromyalgia syndrome (FMS) . Since stress may worsen the pain experience, the development of individual strategies for coping with stress is essential to reduce the impact of FMS on daily life. The aim of the study was to investigate whether a group based stress management cognitive behaviour therapy (CBT) programme could influence self-reported stress, wellbeing and life control, as well as self-reported pain behaviour in female FMS patients...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911652/building-the-evidence-for-crps-research-from-a-lived-experience-perspective
#5
Colleen M Johnston, Florin I Oprescu, Marion Gray
Background and aims Pain is known to be a subjective experience yet the majority of pain related research does not address the lived experience of the condition. Difficult to diagnose, Complex Regional Pain Syndrome (CRPS) is often poorly managed. The aim of this paper was to identify and synthesise the currently available literature on experiences of living with chronic pain in order to understand where and how CRPS research may be best situated in the future. Methods A narrative review was performed and ProQuest, EBSCO, Informit, Scopus/Science Direct and Web of Science, Medline, CINHAL and Google Scholar were searched in order to identify the literature from 1998 until 2015...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911577/the-dynamics-of-the-pain-system-is-intact-in-patients-with-knee-osteoarthritis-an-exploratory-experimental-study
#6
Tanja Schjødt Jørgensen, Marius Henriksen, Sara Rosager, Louise Klokker, Karen Ellegaard, Bente Danneskiold-Samsøe, Henning Bliddal, Thomas Graven-Nielsen
Background and aims Despite the high prevalence of knee osteoarthritis (OA) it remains one of the most frequent knee disorders without a cure. Pain and disability are prominent clinical features of knee OA. Knee OA pain is typically localized but can also be referred to the thigh or lower leg. Widespread hyperalgesia has been found in knee OA patients. In addition, patients with hyperalgesia in the OA knee joint show increased pain summation scores upon repetitive stimulation of the OA knee suggesting the involvement of facilitated central mechanisms in knee OA...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29910145/therapeutic-impact-of-motor-cortex-rtms-in-patients-with-chronic-neuropathic-pain-even-in-the-absence-of-an-analgesic-response-a-case-report
#7
Hasan Hodaj, Jean-François Payen, Jean-Pascal Lefaucheur
OBJECTIVE: To show that repetitive transcranial magnetic stimulation (rTMS) delivered at high frequency over the motor cortex can improve patients with chronic pain syndrome even if this procedure does not provide an analgesic response. CASE REPORT: A 77-year-old woman presented with drug-resistant chronic neuropathic pain affecting both lower limbs due to segmental spine compression at T9-T10 level. She underwent an rTMS protocol with an induction phase of 12 rTMS sessions during three weeks and a maintenance phase of 3 additional rTMS sessions for 5 weeks...
June 14, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/29907605/transthyretin-amyloid-polyneuropathies-mimicking-a-demyelinating-polyneuropathy
#8
Pierre Lozeron, Louise-Laure Mariani, Pauline Dodet, Guillemette Beaudonnet, Marie Théaudin, Clovis Adam, Bertrand Arnulf, David Adams
OBJECTIVE: To clearly define transthyretin familial amyloid polyneuropathies (TTR-FAPs) fulfilling definite clinical and electrophysiologic European Federation of Neurological Societies/Peripheral Nerve Society criteria for chronic inflammatory demyelinating polyneuropathy (CIDP). METHODS: From a cohort of 194 patients with FAP, 13 of 84 patients (15%) of French ancestry had late-onset demyelinating TTR-FAP. We compared clinical presentation and electrophysiology to a cohort with CIDP and POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes) syndrome...
June 15, 2018: Neurology
https://www.readbyqxmd.com/read/29904802/an-update-on-repetitive-transcranial-magnetic-stimulation-for-the-treatment-of-co-morbid-pain-and-depressive-symptoms
#9
REVIEW
Jonathan H Hsu, Zafiris J Daskalakis, Daniel M Blumberger
PURPOSE: Review recent meta-analyses and clinical trials investigating the therapeutic use of repetitive transcranial magnetic stimulation (rTMS) for concurrent pain and depressive symptoms. RECENT FINDINGS: Recent meta-analyses have included both pain and depression outcomes in fibromyalgia and chronic pain. Randomized controlled trials have also been conducted in post-herpetic neuralgia, trauma-related headache, and neuropathic pain with attention to both pain and depressive symptoms...
June 14, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29904631/chronic-diffuse-pain-and-functional-gastrointestinal-disorders-after-traumatic-stress-pathophysiology-through-a-polyvagal-perspective
#10
Jacek Kolacz, Stephen W Porges
Chronic diffuse pain disorders, such as fibromyalgia, and functional gastrointestinal disorders (FGIDs), such as irritable bowel syndrome, place substantial burden on those affected and on the medical system. Despite their sizable impact, their pathophysiology is poorly understood. In contrast to an approach that focuses on the correlation between heart rate variability (HRV) and a specific organ or symptom, we propose that a bio-evolutionary threat-related autonomic response-as outlined in the Polyvagal Theory-may serve as a plausible explanation of how HRV, particularly respiratory sinus arrhythmia (RSA), would index the pathophysiology of these disorders...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29904418/acquired-hypophosphatemic-osteomalacia-is-easily-misdiagnosed-or-neglected-by-rheumatologists-a-report-of-9-cases
#11
Ling Li, Shu-Xia Wang, Hong-Mei Wu, Dong-Lan Luo, Guang-Fu Dong, Yuan Feng, Xiao Zhang
The aim of the present study was to assist rheumatologists in differentiating hypophosphatemic osteomalacia (HO) from mimic rheumatology diseases. Clinical data was obtained from 9 patients with acquired HO, initially misdiagnosed as mimic rheumatologic diseases. The data were retrospectively analyzed and a literature review was performed. The etiology of the cases was as follows: Adefovir dipivoxil-induced Fanconi syndrome was present in 6 of the cases, 2 were tumors and 1 case was chronic nephropathy. The chief complaint was thoracic or back pain and arthralgia, followed by progressive muscle weakness and dramatic movement limitation...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29901619/continuous-radiofrequency-thermocoagulation-under-ct-guidance-for-glossopharyngeal-neuralgia-two-case-reports
#12
Qing Zhu, Shulan Wang, Rui Chen, Xianbin Cai, Cuihua Jiang, Baolin Zhong, Tao Sun
RATIONALE: Glosssopharyngeal neuralgia (GPN) is a painful syndrome characterized by paroxysmal neuropathic pain in the pharynx, tonsil, posterior base of tongue, inner ear, and mandibular angle. The traditional therapies of GPN, including medication and surgical operation, are not always effective in pain controlling. Radiofrequency therapy is a minimally interventional technique to provide analgesia in chronic pain. PATIENT CONCERNS: Two patients who were refractory to medical treatment were hospitalized for primary GPN...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29898646/pure-bone-marrow-aspirate-injection-for-chronic-greater-trochanteric-pain-syndrome-a-case-report
#13
Rachel G Henderson, Ricardo E Colberg
There are limited treatment options for patients with a chronic refractory greater trochanteric pain syndrome. Orthobiologic interventions may stimulate tendon healing and improve pain and function in patients who fail the standard conservative treatment. Since the US FDA's new position statement regarding the centrifugation of bone marrow aspirate products as a potentially 'more than minimally manipulated' product, there is a growing concern about the most common bone marrow aspirate concentrate technique...
June 14, 2018: Pain Management
https://www.readbyqxmd.com/read/29896150/recovery-of-repressed-memories-in-fibromyalgia-patients-treated-with-hyperbaric-oxygen-case-series-presentation-and-suggested-bio-psycho-social-mechanism
#14
Shai Efrati, Amir Hadanny, Shir Daphna-Tekoah, Yair Bechor, Kobi Tiberg, Nimrod Pik, Gil Suzin, Rachel Lev-Wiesel
Fibromyalgia Syndrome (FMS) is a condition considered to represent a prototype of central sensitization syndrome, characterized by chronic widespread pain and along with symptoms of fatigue, non-restorative sleep and cognitive difficulties. FMS can be induced by trauma, infection or emotional stress with cumulative evidence that dissociation is relatively frequent in FMS patients. Two randomized controlled trials have shown that hyperbaric oxygen therapy (HBOT) can induce neuroplasticity and be effective in patients suffering from FMS...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29894812/why-are-there-no-drugs-indicated-for-sciatica-the-most-common-chronic-neuropathic-syndrome-of-all
#15
REVIEW
John D Markman, Ralf Baron, Jennifer S Gewandter
Here, we examine the stark contrast between the successes and failures of the clinical development of analgesics for different types of chronic low back pain (CLBP) syndrome over the past three decades. Multiple drugs with differing mechanisms of action have been developed for nonspecific axial-predominant low back syndromes and yet not a single therapy is indicated for any neuropathic low back pain syndrome (e.g., sciatica). Clinician findings have informed the entry criteria for neuropathic low back pain clinical trials, whereas entry criteria of axial CLBP trials have prioritized only patient reports of pain...
June 9, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29894453/gradenigo-syndrome-induced-by-suppurative-otitis-media
#16
Nazim Bozan, Ufuk Düzenli, Abdulzaziz Yalinkilic, Abdurrahman Ayral, Mehmet Parlak, Mahfuz Turan, Ahmet Faruk Kiroglu
Gradenigo syndrome was defined as a clinical triad of otitis media, severe orbito-facial pain, and ipsilateral sixth cranial nerve palsy. It may occur as a complication of either acute or chronic otitis media. Herein, we will report a case of Gradenigo syndrome induced by suppurative chronic otitis media that was promptly diagnosed and aggressively treated.
June 11, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29890559/severe-eosinophilic-colitis-caused-by-neuropathic-agents-in-a-patient-with-chronic-fatigue-syndrome-and-functional-abdominal-pain-case-report-and-review-of-the-literature
#17
Konstantinos C Fragkos, John Barragry, Charisma Shahi Fernando, Marco Novelli, Joanna Begent, Natalia Zárate-Lopez
Eosinophilic colitis is a rare clinical condition that belongs to the group of eosinophilic gastrointestinal disorders. Its occurrence can be primary or secondary to infection, medications, or autoimmune/hematological conditions. We present a case of a young female adult with severe chronic fatigue syndrome, widespread chronic pain, including functional abdominal pain, who developed severe eosinophilic colitis following successive treatments with gabapentin and pregabalin. On both occasions, symptoms manifested as abdominal pain, diarrhea, and eosinophilia and improved upon discontinuation of the medications...
June 2018: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29889113/the-role-of-appendectomy-at-the-time-of-laparoscopic-surgery-for-benign-gynecologic-conditions
#18
Ann Peters, Suketu M Mansuria
PURPOSE OF REVIEW: The risk-benefit ratio of concurrent appendectomy at the time of gynecologic surgery has long been debated and remains controversial. However, emerging data on the appendix's role in chronic pain syndromes point to a previously unrecognized link between gynecologic disorders and appendicular pathology. In this article, we review the indications for appendectomy at the time of laparoscopic gynecologic surgery for the treatment of endometriosis and chronic pelvic pain...
June 7, 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29886479/intrathecal-baclofen-therapy-for-painful-muscle-spasms-in-a-patient-with-friedreich-s-ataxia
#19
Aristotelis V Kalyvas, Evangelos Drosos, Stefanos Korfias, Stylianos Gatzonis, Marios Themistocleous, Damianos E Sakas
Friedreich's ataxia (FA) is the most frequent hereditary ataxia syndrome, while painful muscle spasms and spasticity have been reported in 11-15% of FA patients. This report describes the successful management of painful spasms in a 65-year-old woman with FA via intrathecal baclofen (ITB) therapy following unsuccessful medical treatments. To our knowledge, this is the third reported case in the literature. Unfortunately, the pathophysiological characteristics of muscle spasms in FA are not well explored and understood while the therapeutic mechanisms of the different treatments are rather vague...
June 8, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29885664/zumba-induced-takotsubo-cardiomyopathy-a-case-report
#20
Sana Chams, Skye El Sayegh, Mulham Hamdon, Sarwan Kumar, Zain Kulairi
BACKGROUND: Takotsubo cardiomyopathy or stress cardiomyopathy is characterized by transient left ventricular apical ballooning in the absence of coronary occlusion. The underlying pathophysiological mechanism is still unclear but possible causes have been proposed mainly catecholamine cardiotoxicity, followed by metabolic disturbance, coronary microvascular impairment, and multivessel epicardial coronary artery vasospasm. Takotsubo cardiomyopathy accounts for 1-2% of patients presenting with acute coronary syndrome with the majority of patients diagnosed with Takotsubo cardiomyopathy being women > 55 years of age...
June 10, 2018: Journal of Medical Case Reports
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