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Chronic pain syndrome

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https://www.readbyqxmd.com/read/29684510/the-rodent-tibia-fracture-model-a-critical-review-and-comparison-with-the-complex-regional-pain-syndrome-literature
#1
REVIEW
Frank Birklein, Alaa Ibrahim, Tanja Schlereth, Wade S Kingery
Distal limb fracture is the most common cause of complex regional pain syndrome (CRPS), thus the rodent tibia fracture model (TFM) was developed to study CRPS pathogenesis. This comprehensive review summarizes the published TFM research and compares these experimental results with the CRPS literature. The TFM generated spontaneous and evoked pain behaviors, inflammatory symptoms (edema, warmth) and trophic changes (skin thickening, osteoporosis) resembling symptoms in early CRPS. Neuropeptides, inflammatory cytokines, and nerve growth factor (NGF) have been linked to pain behaviors, inflammation, and trophic changes in the TFM model and proliferating keratinocytes were identified as the primary source of cutaneous cytokines and NGF...
April 20, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29682387/surgical-management-of-encapsulating-peritoneal-sclerosis-a-case-report-in-kidney-transplant-patient
#2
R Shahbazov, M Talanian, J L Alejo, F Azari, A Agarwal, K L Brayman
Introduction: Encapsulating peritoneal sclerosis (EPS) is a clinical syndrome of progressive fibrotic change in response to prolonged, repetitive, and typically severe insult to the peritoneal mesothelium, often occurring in the setting of peritoneal dialysis (PD). Clear guidelines for successful management remain elusive. We describe the successful surgical management of EPS in a 28-year-old male s/p deceased donor kidney transplant for end-stage renal disease (ESRD) secondary to focal segmental glomerulosclerosis (FSGS)...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29680006/treatment-of-refractory-category-iii-nonbacterial-chronic-prostatitis-chronic-pelvic-pain-syndrome-with-intraprostatic-injection-of-onabotulinumtoxina-a-prospective-controlled-study
#3
Taha A Abdel-Meguid, Hisham A Mosli, Hasan Farsi, Ahmad Alsayyad, Abdulmalik Tayib, Moataz Sait, Ahmad Abdelsalam
INTRODUCTION: To evaluate the efficacy and safety of intraprostatic injections of onabotulinumtoxinA (onaBoNT-A) to treat refractory chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). MATERIALS AND METHODS: Prospective two-group controlled study. Treatment group included adult men with refractory category-III nonbacterial CP/CPPS who underwent transurethral intraprostatic injections of onaBoNT-A (200 U). Control group included comparable patients who underwent cystoscopy only...
April 2018: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29680002/improving-the-utility-of-clinical-phenotyping-in-interstitial-cystitis-painful-bladder-syndrome-from-upoint-to-input
#4
Alice Crane, Jessica Lloyd, Daniel A Shoskes
INTRODUCTION: The phenotyping system UPOINT has proven effective in classifying patients with Urologic Pelvic Pain Syndromes in a clinically meaningful way and to guide therapy. While highly successful in men with chronic pelvic pain syndrome (CPPS), UPOINT is more limited in patients with interstitial cystitis/painful bladder syndrome (IC/PBS) since by definition all patients have the urinary and organ specific phenotype. Furthermore, AUA guidelines recommend a sequential tiered approach to therapy rather than the multimodal UPOINT scheme...
April 2018: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29670505/selective-fiber-degeneration-in-the-peripheral-nerve-of-a-patient-with-severe-complex-regional-pain-syndrome
#5
Adrien Yvon, Alessandro Faroni, Adam J Reid, Vivien C Lees
Aims: Complex regional pain syndrome (CRPS) is characterized by chronic debilitating pain disproportional to the inciting event and accompanied by motor, sensory, and autonomic disturbances. The pathophysiology of CRPS remains elusive. An exceptional case of severe CRPS leading to forearm amputation provided the opportunity to examine nerve histopathological features of the peripheral nerves. Methods: A 35-year-old female developed CRPS secondary to low voltage electrical injury. The CRPS was refractory to medical therapy and led to functional loss of the forelimb, repeated cutaneous wound infections leading to hospitalization...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29669311/a-new-clinical-model-for-facilitating-the-development-of-pattern-recognition-skills-in-clinical-pain-assessment
#6
David M Walton, James M Elliott
Common, enigmatic musculoskeletal conditions such as whiplash-associated disorder, myofascial pain syndrome, low back pain, headache, fibromyalgia, osteoarthritis, and rotator cuff pathology, account for significant social, economic, and personal burdens on a global scale. Despite their primacy (and shared sequelae) there remains a paucity of available and effective management options for patients with both acute and chronic conditions. Establishing an accurate prognostic or diagnostic profile on a patient-by-patient basis can challenge the insight of both novice and expert clinicians...
April 9, 2018: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/29668612/treatment-by-ultrasound-guided-local-infiltration-in-adhesion-related-abdominal-pain-and-intractable-hiccups-a-case-report
#7
Dan Zhu, Zhi-Yong Gu, Chia-Shiang Lin, Fa-Chuan Nie, Jian Cui
RATIONALE: Abdominal pain and hiccups secondary to intra-abdominal adhesion are surgical complications that are often treated by painkillers and secondary surgeries with an unsatisfactory therapeutic effect. This study presents a new treatment method that uses ultrasound-guided local infiltration in peritoneal and abdominal wall adhesions in patients with hiccups and abdominal pain. PATIENT CONCERNS: A 62-year-old patient presented to our hospital with a history of intractable hiccups and abdominal pain for 30 years...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29667437/transdermal-buprenorphine-for-moderate-chronic-noncancer-pain-syndromes
#8
Joseph V Pergolizzi, Flaminia Coluzzi, Robert Taylor
Chronic noncancer pain has remained a challenging clinical problem. Opioid analgesics are effective, but they are known to be associated with opioid use disorder and potentially treatment-limiting side effects. Buprenorphine is a Schedule III synthetic opioid in the USA with a chemical structure similar to that of morphine but with a longer duration of action, greater potency, and other unique pharmacological attributes. Its role in treatment of chronic noncancer pain may be broader than currently thought. Areas covered: The pharmacokinetics, pharmacodynamics, clinical efficacy, and safety profile of transdermal buprenorphine in moderate chronic noncancer pain syndromes patients will be discussed...
April 23, 2018: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/29649527/recommendations-for-evaluation-and-management-of-pain-in-patients-with-mucopolysaccharidosis-in-latin-america
#9
J M Politei, G Gordillo-González, N Guelbert, C F M Souza, C M Lourenço, M L Solano, M M Junqueira, T S P C Magalhães, A M Martins
The mucopolysaccharidosis (MPS) constitute a heterogeneous group of rare genetic disorders caused by enzymatic deficiencies that lead to the accumulation of glycosaminoglycans (GAGs). Several types of MPS are described, historically numbered from I to IX. Clinical observations strongly suggest the presence of chronic pain in patients with all types of MPS. There are few data in the literature on the evaluation and management of pain in these patients, a fact which can compromise the quality of life even more...
April 9, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29649477/involvement-of-prostatic-interstitial-cells-of-cajal-in-inflammatory-cytokines-elicited-catecholamines-production-implications-for-the-pathophysiology-of-chronic-prostatitis-chronic-pelvic-pain-syndrome-cp-cpps
#10
Jiangping Wang, Bo Zhang, Yong Jiao, Zhibin Xu, Biao Qian, Qinzhang Wang
In a previous work using guinea pig prostate, we have identified a novel interstitial cells of Cajal (ICCs) which possess close contacts between sympathetic nerve bundles and smooth muscle cells. The ability of prostatic ICCs in mediating excitatory neural inputs was therefore studied using isolated murine prostate ICCs by collagenase digestion combined with FACS method. RT-PCR and Western blotting analyses revealed that prostatic ICCs under a quiescent state expressed abundantly the rate-limiting enzymes essential for catecholamine synthesis...
April 9, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29645354/the-price-of-pain-in-chronic-rhinosinusitis
#11
Kristine A Smith, Shaelene Ashby, Richard R Orlandi, Gretchen Oakley, Jeremiah A Alt
BACKGROUND: Chronic rhinosinusitis (CRS) is associated with productivity losses exceeding US$13 billion annually. Although pain is well known to significantly affect patient productivity in other diseases, its economic impact on CRS-related lost productivity has not been examined. The objective of this study was to determine whether CRS-related facial pain correlates with lost productivity in patients with CRS. METHODS: Seventy patients with CRS were enrolled in a cross-sectional investigation...
April 12, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29644069/clinical-course-after-parathyroidectomy-in-adults-with-end-stage-renal-disease-on-maintenance-dialysis
#12
Christopher Thiam Seong Lim, Thevandra Kalaiselvam, Normayah Kitan, Bak Leong Goh
Background: Parathyroidectomy (PTX) is done in cases of secondary hyperparathyroidism from chronic kidney disease to improve renal osteodystrophy. Despite this widespread practice, clinical outcomes regarding the benefits of this procedure are still lacking. Most studies in the literature have opted to report the laboratory outcome instead. Our study aimed to evaluate the postoperative clinical course for patients who had undergone total PTX without autoimplantation. Methods and results: All patients who underwent PTX between January 2010 and February 2014 in a tertiary referral center were included in this study and followed up for 12 months...
April 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29643328/superior-mesenteric-artery-syndrome-in-patients-with-crohn-s-disease-a-description-of-2-cases-studied-with-a-novel-magnetic-resonance-enterography-mre-procedure
#13
Giuseppe Cicero, Tommaso D'Angelo, Antonio Bottari, Giuseppe Costantino, Carmela Visalli, Sergio Racchiusa, Maria Adele Marino, Marco Cavallaro, Luciano Frosina, Alfredo Blandino, Silvio Mazziotti
BACKGROUND Superior mesenteric artery syndrome is caused by vascular compression of the third portion of the duodenum between the aorta and the superior mesenteric artery. It may occur with acute or chronic symptomatology, such as vomiting or postprandial abdominal pain, and it is usually caused by a lack of mesenteric fat pad under conditions of severe weight loss. Crohn's disease can be one of them. CASE REPORT We report 2 cases of Crohn's disease patients with clinical suspicion of jejunal stricture who underwent MR-enterography with a novel approach...
April 12, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29628772/incidence-and-association-factors-for-the-development-of-chronic-post-hysterectomy-pain-at-4-and-6-month-follow-up-a-prospective-cohort-study
#14
Ban Leong Sng, Yin Ying Ching, Nian-Lin R Han, Farida Binte Ithnin, Rehena Sultana, Pryseley Nkouibert Assam, Alex Tiong Heng Sia
Chronic pain has major adverse effects on health-related quality of life and contributes to significant socioeconomic burden. Hysterectomy is a very common gynecological surgery, resulting in chronic post-hysterectomy pain (CPHP), an important pain syndrome. We conducted a prospective cohort study in 216 Asian women who underwent abdominal or laparoscopic hysterectomy for benign conditions. Demographic, psychological, and perioperative data were recorded. Postoperative 4- and 6-month phone surveys were conducted to assess the presence of CPHP and functional impairment...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29625732/healthcare-use-patterns-and-economic-burden-of-chronic-musculoskeletal-pain-in-children-before-diagnosis
#15
Frances Tian, Patsy Guittar, Melissa Moore-Clingenpeel, Gloria Higgins, Stacy P Ardoin, Charles H Spencer, Karla Jones, Bethanne Thomas, Shoghik Akoghlanian, Sharon Bout-Tabaku
OBJECTIVES: To evaluate the healthcare use and costs of amplified musculoskeletal pain syndrome (AMPS) in children before diagnosis. STUDY DESIGN: We performed a retrospective study in children with AMPS at a pediatric rheumatology clinic between 2010 and 2014. Data were abstracted on 80 patients after primary rheumatic diseases were excluded. Healthcare visits, medications and diagnostic testing that occurred in the years before diagnosis were collected. The Medical Expenditure Panel Survey was used to estimate visit costs...
April 3, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29624596/embodied-pain-in-fibromyalgia-disturbed-somatorepresentations-and-increased-plasticity-of-the-body-schema
#16
Endika Martínez, Zigor Aira, Itsaso Buesa, Ibane Aizpurua, Diego Rada, Jon Jatsu Azkue
Fibromyalgia syndrome (FMS) is a highly prevalent, chronic musculoskeletal condition characterized by widespread pain and evoked pain at tender points. This study evaluated various aspects of body awareness in a sample of 14 women with FMS and 13 healthy controls, such as plasticity of the body schema, body esteem, and interoceptive awareness. To this end, the Rubber Hand Illusion (RHI), the Body Esteem Scale (BES), and the Body Perception Questionnaire (BPQ) were used, respectively. Consistent with increased plasticity of the body schema, FMS patients scored higher, with large or very large effect sizes, across all three domains evaluated in the RHI paradigm, namely proprioceptive drift and perceived ownership and motor control over the rubber hand...
2018: PloS One
https://www.readbyqxmd.com/read/29623654/tapentadol-extended-release-in-the-treatment-of-severe-chronic-low-back-pain-and-osteoarthritis-pain
#17
REVIEW
Joseph V Pergolizzi, Robert Taylor, Jo Ann LeQuang, Robert B Raffa, John Bisney
Tapentadol is a novel pain reliever with apparently synergistic dual mechanisms of action, capable of addressing both nociceptive and neuropathic components of chronic pain. As an effective analgesic with good tolerability, tapentadol may be appropriate for patients suffering from severe chronic pain associated with low back pain (LBP) or osteoarthritis (OA). Efficacy studies of tapentadol in populations of patients with severe chronic LBP or OA pain suggest that tapentadol is non-inferior to oxycodone. Its tolerability, especially with respect to gastrointestinal (GI) side effects, may be better than that of other strong opioids in clinical trials and analyses of multiple trials...
April 5, 2018: Pain and Therapy
https://www.readbyqxmd.com/read/29623059/cognitive-impairments-in-fibromyalgia-syndrome-associations-with-positive-and-negative-affect-alexithymia-pain-catastrophizing-and-self-esteem
#18
Carmen M Galvez-Sánchez, Gustavo A Reyes Del Paso, Stefan Duschek
Fibromyalgia syndrome (FMS) is a chronic condition characterized by widespread pain accompanied by symptoms like depression, anxiety, sleep disturbance and fatigue. In addition, affected patients frequently report cognitive disruption such as forgetfulness, concentration difficulties or mental slowness. Though cognitive deficits in FMS have been confirmed in various studies, not much is known about the mechanisms involved in their origin. This study aimed to investigate the contribution of affect-related variables to cognitive impairments in FMS...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29614328/recommendations-for-evaluation-and-management-of-pain-in-patients-with-mucopolysaccharidosis-in-latin-america
#19
J M Politei, G Gordillo-González, N Guelbert, C F M Souza, C M Lourenço, M L Solano, M M Junqueira, T S P C Magalhães, A M Martins
The mucopolysaccharidosis (MPS) constitute a heterogeneous group of rare genetic disorders caused by enzymatic deficiencies that lead to the accumulation of glycosaminoglycans (GAGs). Several types of MPS are described, historically numbered from I to IX. Clinical observations strongly suggest the presence of chronic pain in patients with all types of MPS. There are few data in the literature on the evaluation and management of pain in these patients, a fact which can compromise the quality of life even more...
March 31, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29610453/sj%C3%A3-gren-s-syndrome-associated-with-fanconi-s-syndrome-and-osteomalacia
#20
Jorge O Gutierrez, Maria F Zurita, Luis A Zurita
BACKGROUND Sjögren's syndrome is a chronic inflammatory autoimmune disease, which is also known as sicca syndrome, due to the symptoms of dry eyes and dry mouth, and is associated with other connective tissue diseases and autoimmune diseases. Sjögren's syndrome can also be associated with renal involvement. Fanconi's syndrome is associated with impaired reabsorption in the proximal renal tubule associated with tubulointerstitial nephritis and is associated with renal tubular acidosis and hypophosphatemia...
April 3, 2018: American Journal of Case Reports
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