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https://www.readbyqxmd.com/read/29775732/il4-10-fusion-protein-has-chondroprotective-anti-inflammatory-and-potentially-analgesic-effects-in-the-treatment-of-osteoarthritis
#1
C Steen-Louws, J Popov-Celeketic, S C Mastbergen, K Coeleveld, C E Hack, N Eijkelkamp, M Tryfonidou, S Spruijt, J A G van Roon, F P J G Lafeber
OBJECTIVE: Effective disease-modifying drugs for osteoarthritis (DMOAD) should preferably have chondroprotective, anti-inflammatory, and analgesic activity combined in a single molecule. We developed a fusion protein of IL4 and IL10 (IL4-10 FP), in which the biological activity of both cytokines is preserved. The present study evaluates the chondroprotective, anti-inflammatory, and analgesic activity of IL4-10 FP in in vitro and in vivo models of osteoarthritis. METHODS: Human osteoarthritic cartilage tissue and synovial tissue were cultured with IL4-10 FP...
May 15, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29753022/determinants-of-heart-rate-variability-in-the-general-population-the-lifelines-cohort-study-determinants-of-heart-rate-variability
#2
Balewgizie Sileshi Tegegne, Tengfei Man, Arie M van Roon, Harriëtte Riese, Harold Snieder
BACKGROUND: Heart rate variability (HRV) is an important marker of heart health with low values reflecting reduced vagal control of the heart rhythm. OBJECTIVE: The aim of this study was to investigate to what extent a broad range of demographic (age, sex), lifestyle (physical activity, smoking, alcohol use) and psychosocial factors (stress, social wellbeing, neuroticism) explained individual differences in HRV in the general population. METHODS: Using baseline data of 10 second electrocardiograms (ECG) from the Lifelines cohort study (n=149,205;58...
May 9, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29748211/anti-leukemic-efficacy-of-bet-inhibitor-in-a-preclinical-mouse-model-of-mll-af4-infant-all
#3
Michela Bardini, Luca Trentin, Francesca Rizzo, Margherita Vieri, Angela M Savino, Patricia Garrido Castro, Grazia Fazio, Eddy H J Van Roon, Mark Kerstjens, Nicholas N Smithers, Rab K Prinjha, Geertruy Te Kronnie, Giuseppe Basso, Ronald W Stam, Rob Pieters, Andrea Biondi, Giovanni Cazzaniga
MLL-rearranged acute lymphoblastic leukemia occurring in infants is a rare but very aggressive leukemia, typically associated with a dismal prognosis. Despite the development of specific therapeutic protocols, infant patients with MLL-rearranged ALL still suffer from a low cure rate. At present, novel therapeutic approaches are urgently needed. Recently, the use of small molecule inhibitors targeting the epigenetic regulators of the MLL complex emerged as a promising strategy for the development of a targeted therapy...
May 10, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29706885/brain-transcriptomic-analysis-of-hereditary-cerebral-hemorrhage-with-amyloidosis-dutch-type
#4
Laure Grand Moursel, Willeke M C van Roon-Mom, Szymon M Kiełbasa, Hailiang Mei, Henk P J Buermans, Linda M van der Graaf, Kristina M Hettne, Emile J de Meijer, Sjoerd G van Duinen, Jeroen F J Laros, Mark A van Buchem, Peter A C 't Hoen, Silvère M van der Maarel, Louise van der Weerd
Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) is an early onset hereditary form of cerebral amyloid angiopathy (CAA) caused by a point mutation resulting in an amino acid change (NP_000475.1:p.Glu693Gln) in the amyloid precursor protein (APP). Post-mortem frontal and occipital cortical brain tissue from nine patients and nine age-related controls was used for RNA sequencing to identify biological pathways affected in HCHWA-D. Although previous studies indicated that pathology is more severe in the occipital lobe in HCHWA-D compared to the frontal lobe, the current study showed similar changes in gene expression in frontal and occipital cortex and the two brain regions were pooled for further analysis...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29656178/generation-of-3-spinocerebellar-ataxia-type-1-sca1-patient-derived-induced-pluripotent-stem-cell-lines-lumci002-a-b-and-c-and-2-unaffected-sibling-control-induced-pluripotent-stem-cell-lines-lumci003-a-and-b
#5
Ronald A M Buijsen, Sarah L Gardiner, Marga J Bouma, Linda M van der Graaf, Merel W Boogaard, Barry A Pepers, Bert Eussen, Annelies de Klein, Christian Freund, Willeke M C van Roon-Mom
Spinocerebellar ataxia type 1 (SCA1) is a hereditary neurodegenerative disease caused by a CAG repeat expansion in exon 8 of the ATXN1 gene. We generated induced pluripotent stem cells (hiPSCs) from a SCA1 patient and his non-affected sister by using non-integrating Sendai Viruses (SeV). The resulting hiPSCs are SeVfree, express pluripotency markers, display a normal karyotype, retain the mutation (length of the CAG repeat expansion in the ATXN1 gene) and are able to differentiate into the three germ layers in vitro...
April 5, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29620999/dose-dependent-lowering-of-mutant-huntingtin-using-antisense-oligonucleotides-in-huntington-disease-patients
#6
Willeke M C van Roon-Mom, Raymund A C Roos, Susanne T de Bot
On December 11 of 2017, Ionis Pharmaceuticals published a press release announcing dose-dependent reductions of mutant huntingtin protein in their HTTRx Phase 1/2a study in Huntington disease (HD) patients. The results from this Ionis trial have gained much attention from the patient community and the oligonucleotide therapeutics field, since it is the first trial targeting the cause of HD, namely the mutant huntingtin protein, using antisense oligonucleotides (ASOs). The press release also states that the primary endpoints of the study (safety and tolerability) were met, but does not contain data...
April 2018: Nucleic Acid Therapeutics
https://www.readbyqxmd.com/read/29608758/neutrophil-extracellular-trap-release-is-associated-with-antinuclear-antibodies-in-systemic-lupus-erythematosus-and-anti-phospholipid-syndrome
#7
Maarten van der Linden, Lucas L van den Hoogen, Geertje H A Westerlaken, Ruth D E Fritsch-Stork, Joël A G van Roon, Timothy R D J Radstake, Linde Meyaard
Objectives: Increased release of neutrophil extracellular traps (NETs) is implicated in the activation of plasmacytoid dendritic cells, vascular disease and thrombosis in SLE and APS. However, studies comparing NET release between patients with SLE and APS are lacking. Here we evaluated plasma-induced NET release in a large cohort of patients with SLE, SLE + APS and primary APS in relation to clinical and serological parameters. Methods: Neutrophils from healthy controls were exposed to plasma of heterologous healthy controls (n = 27) or SLE (n = 55), SLE + APS (n = 38) or primary APS (PAPS) (n = 28) patients and NET release was quantified by immunofluorescence...
March 28, 2018: Rheumatology
https://www.readbyqxmd.com/read/29565739/intracerebroventricular-administration-of-a-2-o-methyl-phosphorothioate-antisense-oligonucleotide-results-in-activation-of-the-innate-immune-system-in-mouse-brain
#8
Lodewijk J A Toonen, João Casaca-Carreira, Maria Pellisé-Tintoré, Hailiang Mei, Yasin Temel, Ali Jahanshahi, Willeke M C van Roon-Mom
Antisense oligonucleotides (AONs) are versatile molecules that can be used to modulate gene expression by binding to RNA. The therapeutic potential of AONs appears particularly high in the central nervous system, due to excellent distribution and uptake in brain cells, as well as good tolerability in clinical trials thus far. Nonetheless, immune stimulation in response to AON treatment in the brain remains a concern. For this reason we performed RNA sequencing analysis of brain tissue from mice treated intracerebroventricularly with phosphorothioate, 2'-O-methyl modified AONs...
March 22, 2018: Nucleic Acid Therapeutics
https://www.readbyqxmd.com/read/29545339/the-impact-of-the-introduction-of-bortezomib-on-dialysis-independence-in-multiple-myeloma-patients-with-renal-impairment-a-nationwide-dutch-population-based-study
#9
Berdien E Oortgiesen, Roshna Azad, Marc H Hemmelder, Robby E Kibbelaar, Nic J G M Veeger, Joost C de Vries, Eric N van Roon, Mels Hoogendoorn
No abstract text is available yet for this article.
March 15, 2018: Haematologica
https://www.readbyqxmd.com/read/29543610/decision-making-and-outcome-of-pregnancies-in-female-patients-with-inflammatory-bowel-disease-findings-from-a-community-based-practice
#10
Jildou Hoekstra, Aafke H C van Roon, Frank C Bekkering, Antonie J P van Tilburg, Rachel L West
INTRODUCTION: The aim of this study was to evaluate information provided on pregnancy, personal decision making, disease course, and outcome of pregnancy from a patient's perspective in a population of patients with inflammatory bowel disease (IBD) attending two general hospitals. PATIENTS AND METHODS: A questionnaire was sent to all female patients with IBD in two general hospitals in the Netherlands. The questionnaire comprised four sections: (i) demographic data and medication use (ii) details on previous pregnancies and reasons for not becoming pregnant, (iii) outcome of pregnancies before IBD diagnosis, and (iv) outcome of pregnancies after IBD diagnosis...
March 14, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29526636/optimizing-conventional-dmard-therapy-for-sj%C3%A3-gren-s-syndrome
#11
REVIEW
E H M van der Heijden, A A Kruize, T R D J Radstake, J A G van Roon
No abstract text is available yet for this article.
May 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29516310/non-invasive-bladder-volume-measurement-for-the-prevention-of-postoperative-urinary-retention-validation-of-two-ultrasound-devices-in-a-clinical-setting
#12
Tammo A Brouwer, Charina van den Boogaard, Eric N van Roon, Cor J Kalkman, Nic Veeger
Ultrasound scanning of bladder volume is used for prevention of postoperative urinary retention (POUR). Accurate assessment of bladder volume is needed to allow clinical decision-making regarding the need for postoperative catheterization. Two commonly used ultrasound devices, the BladderScan® BVI 9400 and the newly released Prime® (Verathon Medical®, Bothell, WA, USA), with or without the 'pre-scan' option, have not been validated in clinical practice. The aim of this study was to assess the performance of these devices in daily clinical practice...
March 7, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29506240/longitudinal-nailfold-capillaroscopy-tracking-of-microangiopathic-changes-in-systemic-sclerosis
#13
Graham Dinsdale, Anniek M van Roon, Andrea Murray, Christopher Taylor, Ariane L Herrick
No abstract text is available yet for this article.
February 28, 2018: Rheumatology
https://www.readbyqxmd.com/read/29484613/limited-evidence-for-risk-factors-for-proarrhythmia-and-sudden-cardiac-death-in-patients-using-antidepressants-dutch-consensus-on-ecg-monitoring
#14
Mirjam Simoons, Adrie Seldenrijk, Hans Mulder, Tom Birkenhäger, Mascha Groothedde-Kuyvenhoven, Rob Kok, Cornelis Kramers, Wim Verbeeck, Mirjam Westra, Eric van Roon, Roberto Bakker, Henricus Ruhé
Currently, there is a lack of international and national guidelines or consensus documents with specific recommendations for electrocardiogram (ECG) screening and monitoring during antidepressant treatment. To make a proper estimation of the risk of cardiac arrhythmias and sudden (cardiac) death during antidepressant use, both the drug and patient-specific factors should be taken into account; however, solid evidence on how this should be done in clinical practice is lacking. Available recommendations on the management of QT(c) prolongation (with antidepressant treatment) emphasize that special attention should be given to high-risk patients; however, clinicians are in need of more concrete suggestions about how to select patients for ECG screening and monitoring...
February 26, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29447268/circulating-small-non-coding-rnas-reflect-ifn-status-and-b-cell-hyperactivity-in-patients-with-primary-sj%C3%A3-gren-s-syndrome
#15
Ana P Lopes, Maarten R Hillen, Eleni Chouri, Sofie L M Blokland, Cornelis P J Bekker, Aike A Kruize, Marzia Rossato, Joel A G van Roon, Timothy R D J Radstake
BACKGROUND: Considering the important role of miRNAs in the regulation of post-transcriptional expression of target genes, we investigated circulating small non-coding RNAs (snc)RNA levels in patients with primary Sjögren's syndrome (pSS). In addition we assessed if serum sncRNA levels can be used to differentiate patients with specific disease features. METHODS: Serum RNA was isolated from 37 pSS patients as well as 21 patients with incomplete Sjögren's Syndrome (iSS) and 17 healthy controls (HC) allocated to two independent cohorts: discovery and validation...
2018: PloS One
https://www.readbyqxmd.com/read/29371048/serum-microrna-screening-and-functional-studies-reveal-mir-483-5p-as-a-potential-driver-of-fibrosis-in-systemic-sclerosis
#16
Eleni Chouri, Nila H Servaas, Cornelis P J Bekker, Alsya J Affandi, Marta Cossu, Maarten R Hillen, Chiara Angiolilli, Jorre S Mertens, Lucas L van den Hoogen, Sandra Silva-Cardoso, Maarten van der Kroef, Nadia Vazirpanah, Catharina G K Wichers, Tiago Carvalheiro, Sofie L M Blokland, Barbara Giovannone, Laura Porretti, Wioleta Marut, Barbara Vigone, Joel A G van Roon, Lorenzo Beretta, Marzia Rossato, Timothy R D J Radstake
OBJECTIVE: MicroRNAs (miRNAs) are regulatory molecules, which have been addressed as potential biomarkers and therapeutic targets in rheumatic diseases. Here, we investigated the miRNA signature in the serum of systemic sclerosis (SSc) patients and we further assessed their expression in early stages of the disease. METHODS: The levels of 758 miRNAs were evaluated in the serum of 26 SSc patients as compared to 9 healthy controls by using an Openarray platform. Three miRNAs were examined in an additional cohort of 107 SSc patients and 24 healthy donors by single qPCR...
May 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29367218/orthostatic-blood-pressure-recovery-patterns-in-suspected-syncope-in-the-emergency-department
#17
Veera K van Wijnen, Dik Ten Hove, Reinold O B Gans, Wybe Nieuwland, Arie M van Roon, Jan C Ter Maaten, Mark P M Harms
INTRODUCTION: Orthostasis is a frequent trigger for (pre)syncope but some forms of orthostatic (pre)syncope have a worse prognosis than others. Routine assessment of orthostatic BP in the ED can detect classic orthostatic hypotension, but often misses these other forms of orthostatic (pre)syncope. This study aimed to determine the frequency of abnormal orthostatic BP recovery patterns in patients with (pre)syncope by using continuous non-invasive BP monitoring. METHODS: We performed a prospective cohort study in suspected patients with (pre)syncope in the ED of a tertiary care teaching hospital between January and August 2014...
April 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29324884/a-cross-sectional-study-on-dutch-layer-farms-to-investigate-the-prevalence-and-potential-risk-factors-for-different-chlamydia-species
#18
Marloes Heijne, Jeanet A van der Goot, Helmi Fijten, Joke W van der Giessen, Eric Kuijt, Catharina B M Maassen, Annika van Roon, Ben Wit, Ad P Koets, Hendrik I J Roest
In poultry several Chlamydia species have been detected, but Chlamydia psittaci and Chlamydia gallinacea appear to be most prevalent and important. Chlamydia psittaci is a well-known zoonosis and is considered to be a pathogen of poultry. Chlamydia gallinacea has been described more recently. Its avian pathogenicity and zoonotic potential have to be further elucidated. Within the Netherlands no data were available on the presence of Chlamydia on poultry farms. As part of a surveillance programme for zoonotic pathogens in farm animals, we investigated pooled faecal samples from 151 randomly selected layer farms...
2018: PloS One
https://www.readbyqxmd.com/read/29298214/heart-rate-variability-and-its-relation-to-chronic-kidney-disease-results-from-the-prevend-study
#19
Christian H L Thio, Arie M van Roon, Joop D Lefrandt, Ron T Gansevoort, Harold Snieder
OBJECTIVE: In the general population, reduced heart rate variability (HRV) has been associated with cardiovascular disease. However, its relation to chronic kidney disease (CKD) is debated. We therefore investigated the relation between low HRV and renal outcomes. METHODS: In the population-based Prevention of REnal and Vascular ENdstage Disease study, renal outcomes (CKD, estimated glomerular filtration rate [eGFR], urinary albumin) were measured at baseline and three consecutive examinations...
April 2018: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29249939/co-expression-patterns-between-atn1-and-atxn2-coincide-with-brain-regions-affected-in-huntington-s-disease
#20
Arlin Keo, N Ahmad Aziz, Oleh Dzyubachyk, Jeroen van der Grond, Willeke M C van Roon-Mom, Boudewijn P F Lelieveldt, Marcel J T Reinders, Ahmed Mahfouz
Cytosine-adenine-guanine (CAG) repeat expansions in the coding regions of nine polyglutamine (polyQ) genes ( HTT , ATXN1 , ATXN2 , ATXN3 , CACNA1A , ATXN7 , ATN1 , AR , and TBP ) are the cause of several neurodegenerative diseases including Huntington's disease (HD), six different spinocerebellar ataxias (SCAs), dentatorubral-pallidoluysian atrophy, and spinobulbar muscular atrophy. The expanded CAG repeat length in the causative gene is negatively related to the age-at-onset (AAO) of clinical symptoms. In addition to the expanded CAG repeat length in the causative gene, the normal CAG repeats in the other polyQ genes can affect the AAO, suggesting functional interactions between the polyQ genes...
2017: Frontiers in Molecular Neuroscience
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