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https://www.readbyqxmd.com/read/28076669/medication-discrepancies-at-outpatient-departments-for-mood-and-anxiety-disorders-in-the-netherlands-risks-and-clinical-relevance
#1
Mirjam Simoons, Hans Mulder, Arne J Risselada, Frederik W Wilmink, Robert Schoevers, Henricus G Ruhé, Eric N van Roon
OBJECTIVE: To identify discrepancies between actual drug use by outpatients with mood and anxiety disorders and medication overviews from health care providers as well as to investigate the clinical relevance of those discrepancies. METHODS: A cross-sectional study in adults visiting 1 of 4 participating outpatient departments for mood and anxiety disorders was conducted between March and November 2014. DSM-5 criteria were used to assign the psychiatric diagnosis...
November 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28017939/huntingtin-is-a-scaffolding-protein-in-the-atm-oxidative-dna-damage-response-complex
#2
Tamara Maiuri, Andrew J Mocle, Claudia L Hung, Jianrun Xia, Willeke M C van Roon-Mom, Ray Truant
Huntington's disease (HD) is an age-dependent neurodegenerative disease. DNA repair pathways have recently been implicated as the most predominant modifiers of age of onset in HD patients. We report that endogenous huntingtin protein directly participates in oxidative DNA damage repair. Using novel chromobodies to detect endogenous human huntingtin in live cells, we show that localization of huntingtin to DNA damage sites is dependent on the kinase activity of ataxia telangiectasia mutated (ATM) protein. Super-resolution microscopy and biochemical assays revealed that huntingtin co-localizes with and scaffolds proteins of the DNA damage response pathway in response to oxidative stress...
December 25, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27987023/comparative-study-of-episiotomy-angles-achieved-by-cutting-with-straight-mayo-scissors-and-the-episcissors-60-in-a-birth-simulation-model
#3
Yves van Roon, Latha Vinayakarao, Louise Melson, Rebecca Percival, Sangeeta Pathak, Ashish Pradhan
INTRODUCTION AND HYPOTHESIS: We compared the clinician's ability to cut episiotomies at the recommended 60° angle with traditional straight Mayo scissors compared with patented fixed-angle episiotomy scissors EPISCISSORS-60® in a simulated setting using mounted incision pads. The hypothesis was that fixed-angle episiotomies would achieve a more accurate cutting angle of 60°. METHODS: Angles were cut on episiotomy incision pads in a mounted birth model simulating crowning: 110 midwives and doctors cut an 60° episiotomy with Mayo scissors and then EPISCISSORS-60...
December 16, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/27981025/long-term-effects-of-a-weight-loss-intervention-with-or-without-exercise-component-in-postmenopausal-women-a-randomized-trial
#4
Martijn de Roon, Willemijn A van Gemert, Petra H Peeters, Albertine J Schuit, Evelyn M Monninkhof
The aim of this study was to determine the long-term effects of a weight loss intervention with or without an exercise component on body weight and physical activity. Women were randomized to diet (n = 97) or exercise (N = 98) for 16 weeks. During the intervention, both groups had achieved the set goal of 5-6 kg weight loss. All women were re-contacted twelve months after study cessation for follow-up where body weight and physical activity were measured (PASE questionnaire and ActiGraph accelerometer)...
March 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/27887781/high-psychosis-liability-is-associated-with-altered-autonomic-balance-during-exposure-to-virtual-reality-social-stressors
#5
Jacqueline Counotte, Roos Pot-Kolder, Arie M van Roon, Olivier Hoskam, Mark van der Gaag, Wim Veling
BACKGROUND: Social stressors are associated with an increased risk of psychosis. Stress sensitisation is thought to be an underlying mechanism and may be reflected in an altered autonomic stress response. Using an experimental Virtual Reality design, the autonomic stress response to social stressors was examined in participants with different liability to psychosis. METHOD: Fifty-five patients with recent onset psychotic disorder, 20 patients at ultra-high risk for psychosis, 42 siblings of patients with psychosis and 53 controls were exposed to social stressors (crowdedness, ethnic minority status and hostility) in a Virtual Reality environment...
November 22, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27884437/evaluation-by-latent-class-analysis-of-a-magnetic-capture-based-dna-extraction-followed-by-real-time-qpcr-as-a-new-diagnostic-method-for-detection-of-echinococcus-multilocularis-in-definitive-hosts
#6
Miriam Maas, Annika van Roon, Cecile Dam-Deisz, Marieke Opsteegh, Alessandro Massolo, Gunita Deksne, Peter Teunis, Joke van der Giessen
A new method, based on a magnetic capture based DNA extraction followed by qPCR, was developed for the detection of the zoonotic parasite Echinococcus multilocularis in definitive hosts. Latent class analysis was used to compare this new method with the currently used phenol-chloroform DNA extraction followed by single tube nested PCR. In total, 60 red foxes and coyotes from three different locations were tested with both molecular methods and the sedimentation and counting technique (SCT) or intestinal scraping technique (IST)...
October 30, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27747155/first-findings-of-trichinella-spiralis-and-dna-of-echinococcus-multilocularis-in-wild-raccoon-dogs-in-the-netherlands
#7
Miriam Maas, Sanne van den End, Annika van Roon, Jaap Mulder, Frits Franssen, Cecile Dam-Deisz, Margriet Montizaan, Joke van der Giessen
The recent invasion of the raccoon dog in the Netherlands may be associated with the risk of introduction and spread of zoonotic pathogens. The aim of this study was to assess whether Echinococcus multilocularis and Trichinella spp. infections are present in Dutch raccoon dogs. Between 2013 and 2014, nine raccoon dogs, mainly road kills, were collected for necropsies. One raccoon dog tested repeatedly positive in the qPCR for E. multilocularis. The positive raccoon dog was collected in the province of Flevoland, which is not a known endemic region for E...
December 2016: International Journal for Parasitology. Parasites and Wildlife
https://www.readbyqxmd.com/read/27731380/antisense-oligonucleotide-mediated-exon-skipping-as-a-strategy-to-reduce-proteolytic-cleavage-of-ataxin-3
#8
Lodewijk J A Toonen, Iris Schmidt, Martijn S Luijsterburg, Haico van Attikum, Willeke M C van Roon-Mom
Spinocerebellar ataxia type-3 (SCA3) is a neurodegenerative disorder caused by a polyglutamine repeat expansion in the ataxin-3 protein. Cleavage of mutant ataxin-3 by proteolytic enzymes yields ataxin-3 fragments containing the polyglutamine stretch. These shorter ataxin-3 fragments are thought to be involved in SCA3 pathogenesis due to their increased cellular toxicity and their involvement in formation of the characteristic neuronal aggregates. As a strategy to prevent formation of toxic cleavage fragments, we investigated an antisense oligonucleotide-mediated modification of the ataxin-3 pre-mRNA through exon skipping of exon 8 and 9, resulting in the removal of a central 88 amino acid region of the ataxin-3 protein...
October 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27639545/in-vivo-proof-of-concept-of-removal-of-the-huntingtin-caspase-cleavage-motif-encoding-exon-12-approach-in-the-yac128-mouse-model-of-huntington-s-disease
#9
João Casaca-Carreira, Lodewijk J A Toonen, Melvin M Evers, Ali Jahanshahi, Willeke M C van-Roon-Mom, Yasin Temel
Huntington's disease (HD) is a progressive autosomal dominant disease, caused by a CAG repeat expansion in the HTT gene, resulting in an expanded polyglutamine stretch at the N-terminal of the huntingtin protein. An important event in HD pathogenesis appears to be the proteolysis of the mutant protein, which forms N-terminal huntingtin fragments. These fragments form insoluble aggregates and are found in nuclei and cytoplasm of affected neurons where they interfere with normal cell functioning. Important cleavage sites are encoded by exon 12 of HTT...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27615381/frequency-of-nuclear-mutant-huntingtin-inclusion-formation-in-neurons-and-glia-is-cell-type-specific
#10
Anne H P Jansen, Maurik van Hal, Ilse C Op den Kelder, Romy T Meier, Anna-Aster de Ruiter, Menno H Schut, Donna L Smith, Corien Grit, Nieske Brouwer, Willem Kamphuis, H W G M Boddeke, Wilfred F A den Dunnen, Willeke M C van Roon, Gillian P Bates, Elly M Hol, Eric A Reits
Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disorder that is caused by a CAG expansion in the Huntingtin (HTT) gene, leading to HTT inclusion formation in the brain. The mutant huntingtin protein (mHTT) is ubiquitously expressed and therefore nuclear inclusions could be present in all brain cells. The effects of nuclear inclusion formation have been mainly studied in neurons, while the effect on glia has been comparatively disregarded. Astrocytes, microglia, and oligodendrocytes are glial cells that are essential for normal brain function and are implicated in several neurological diseases...
January 2017: Glia
https://www.readbyqxmd.com/read/27571731/4-aminopyridine-as-a-life-saving-treatment-in-calcium-channel-antagonist-intoxication
#11
P H J van der Voort, B Wilffert, E N van Roon, D R A Uges
No abstract text is available yet for this article.
July 2016: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/27524956/integration-of-targeted-metabolomics-and-transcriptomics-identifies-deregulation-of-phosphatidylcholine-metabolism-in-huntington-s-disease-peripheral-blood-samples
#12
Anastasios Mastrokolias, Rene Pool, Eleni Mina, Kristina M Hettne, Erik van Duijn, Roos C van der Mast, GertJan van Ommen, Peter A C 't Hoen, Cornelia Prehn, Jerzy Adamski, Willeke van Roon-Mom
INTRODUCTION: Metabolic changes have been frequently associated with Huntington's disease (HD). At the same time peripheral blood represents a minimally invasive sampling avenue with little distress to Huntington's disease patients especially when brain or other tissue samples are difficult to collect. OBJECTIVES: We investigated the levels of 163 metabolites in HD patient and control serum samples in order to identify disease related changes. Additionally, we integrated the metabolomics data with our previously published next generation sequencing-based gene expression data from the same patients in order to interconnect the metabolomics changes with transcriptional alterations...
2016: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/27494755/size-matters-decreased-glandular-levels-of-anti-inflammatory-short-thymic-stromal-lymphopoietin-in-primary-sj%C3%A3-gren-s-syndrome
#13
LETTER
Maarten R Hillen, Frederique M Moret, Barbara Giovannone, Aike A Kruize, Timothy R D J Radstake, Joel A G van Roon
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September 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27476530/common-disease-signatures-from-gene-expression-analysis-in-huntington-s-disease-human-blood-and-brain
#14
Eleni Mina, Willeke van Roon-Mom, Kristina Hettne, Erik van Zwet, Jelle Goeman, Christian Neri, Peter A C 't Hoen, Barend Mons, Marco Roos
BACKGROUND: Huntington's disease (HD) is a devastating brain disorder with no effective treatment or cure available. The scarcity of brain tissue makes it hard to study changes in the brain and impossible to perform longitudinal studies. However, peripheral pathology in HD suggests that it is possible to study the disease using peripheral tissue as a monitoring tool for disease progression and/or efficacy of novel therapies. In this study, we investigated if blood can be used to monitor disease severity and progression in brain...
2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27440947/perceiving-while-producing-modeling-the-dynamics-of-phonological-planning
#15
Kevin D Roon, Adamantios I Gafos
We offer a dynamical model of phonological planning that provides a formal instantiation of how the speech production and perception systems interact during online processing. The model is developed on the basis of evidence from an experimental task that requires concurrent use of both systems, the so-called response-distractor task in which speakers hear distractor syllables while they are preparing to produce required responses. The model formalizes how ongoing response planning is affected by perception and accounts for a range of results reported across previous studies...
August 2016: Journal of Memory and Language
https://www.readbyqxmd.com/read/27428811/closing-in-on-the-role-of-tslp-inhibition-as-a-therapeutic-entry-point-for-systemic-sclerosis
#16
Alsya A Affandi, Joel A G van Roon
No abstract text is available yet for this article.
July 18, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27413147/il4-10-fusion-protein-is-a-novel-drug-to-treat-persistent-inflammatory-pain
#17
Niels Eijkelkamp, Cristine Steen-Louws, Sarita A Y Hartgring, Hanneke L D M Willemen, Judith Prado, Floris P J G Lafeber, Cobi J Heijnen, C E Hack, Joel A G van Roon, Annemieke Kavelaars
UNLABELLED: Chronic pain is a major clinical problem that is difficult to treat and requires novel therapies. Although most pain therapies primarily target neurons, neuroinflammatory processes characterized by spinal cord and dorsal root ganglion production of proinflammatory cytokines play an important role in persistent pain states and represent potential therapeutic targets. Anti-inflammatory cytokines are attractive candidates to regulate aberrant neuroinflammatory processes, but the therapeutic potential of these cytokines as stand-alone drugs is limited...
July 13, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27377233/endolymph-movement-visualized-with-light-sheet-fluorescence-microscopy-in-an-acute-hydrops-model
#18
Daniel J Brown, Christopher J Pastras, Ian S Curthoys, Cassandra S Southwell, Lieke Van Roon
There are a variety of techniques available to investigate endolymph dynamics, primarily seeking to understand the cause of endolymphatic hydrops. Here we have taken the novel approach of injecting, via a glass micropipette, fluorescein isothiocyanate-dextran (FITC-dex) and artificial endolymph into scala media of anaesthetized guinea pigs, with subsequent imaging of the inner ear using Light Sheet Fluorescence Microscopy (LSFM) as a means to obtain highly resolved 3D visualization of fluid movements. Our results demonstrate endolymph movement into the utricle, semicircular canals and endolymphatic duct and sac when more than 2...
September 2016: Hearing Research
https://www.readbyqxmd.com/read/27322917/vascular-fingerprint-and-vascular-damage-markers-associated-with-vascular-events-in-testicular-cancer-patients-during-and-after-chemotherapy
#19
S Lubberts, H Boer, R Altena, C Meijer, A M van Roon, N Zwart, S F Oosting, P W Kamphuisen, J Nuver, A J Smit, A B Mulder, J D Lefrandt, J A Gietema
BACKGROUND: Metastatic testicular cancer (TC) can be cured with bleomycin, etoposide and cisplatin (BEP) chemotherapy. This comes at the price of an increased cardiovascular disease risk, not only years afterwards, but also during and shortly after chemotherapy. To prevent cardiovascular events, high-risk patients should be identified. The aim of this study was to assess BEP-chemotherapy induced vascular damage and to find risk factors for early vascular events. PATIENTS AND METHODS: A prospective cohort study was performed in (B)EP treated TC patients...
August 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27298364/activation-of-the-molecular-chaperone-sigma-1-receptor-preserves-cone-function-in-a-murine-model-of-inherited-retinal-degeneration
#20
Jing Wang, Alan Saul, Penny Roon, Sylvia B Smith
Retinal degenerative diseases are major causes of untreatable blindness, and novel approaches to treatment are being sought actively. Here we explored the activation of a unique protein, sigma 1 receptor (Sig1R), in the treatment of PRC loss because of its multifaceted role in cellular survival. We used Pde6β(rd10) (rd10) mice, which harbor a mutation in the rod-specific phosphodiesterase gene Pde6β and lose rod and cone photoreceptor cells (PRC) within the first 6 wk of life, as a model for severe retinal degeneration...
June 28, 2016: Proceedings of the National Academy of Sciences of the United States of America
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