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Miriam Maas, Sanne van den End, Annika van Roon, Jaap Mulder, Frits Franssen, Cecile Dam-Deisz, Margriet Montizaan, Joke van der Giessen
The recent invasion of the raccoon dog in the Netherlands may be associated with the risk of introduction and spread of zoonotic pathogens. The aim of this study was to assess whether Echinococcus multilocularis and Trichinella spp. infections are present in Dutch raccoon dogs. Between 2013 and 2014, nine raccoon dogs, mainly road kills, were collected for necropsies. One raccoon dog tested repeatedly positive in the qPCR for E. multilocularis. The positive raccoon dog was collected in the province of Flevoland, which is not a known endemic region for E...
December 2016: International Journal for Parasitology. Parasites and Wildlife
Lodewijk J A Toonen, Iris Schmidt, Martijn S Luijsterburg, Haico van Attikum, Willeke M C van Roon-Mom
Spinocerebellar ataxia type-3 (SCA3) is a neurodegenerative disorder caused by a polyglutamine repeat expansion in the ataxin-3 protein. Cleavage of mutant ataxin-3 by proteolytic enzymes yields ataxin-3 fragments containing the polyglutamine stretch. These shorter ataxin-3 fragments are thought to be involved in SCA3 pathogenesis due to their increased cellular toxicity and their involvement in formation of the characteristic neuronal aggregates. As a strategy to prevent formation of toxic cleavage fragments, we investigated an antisense oligonucleotide-mediated modification of the ataxin-3 pre-mRNA through exon skipping of exon 8 and 9, resulting in the removal of a central 88 amino acid region of the ataxin-3 protein...
October 12, 2016: Scientific Reports
João Casaca-Carreira, Lodewijk J A Toonen, Melvin M Evers, Ali Jahanshahi, Willeke M C van-Roon-Mom, Yasin Temel
Huntington's disease (HD) is a progressive autosomal dominant disease, caused by a CAG repeat expansion in the HTT gene, resulting in an expanded polyglutamine stretch at the N-terminal of the huntingtin protein. An important event in HD pathogenesis appears to be the proteolysis of the mutant protein, which forms N-terminal huntingtin fragments. These fragments form insoluble aggregates and are found in nuclei and cytoplasm of affected neurons where they interfere with normal cell functioning. Important cleavage sites are encoded by exon 12 of HTT...
September 15, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Anne H P Jansen, Maurik van Hal, Ilse C Op den Kelder, Romy T Meier, Anna-Aster de Ruiter, Menno H Schut, Donna L Smith, Corien Grit, Nieske Brouwer, Willem Kamphuis, H W G M Boddeke, Wilfred F A den Dunnen, Willeke M C van Roon, Gillian P Bates, Elly M Hol, Eric A Reits
Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disorder that is caused by a CAG expansion in the Huntingtin (HTT) gene, leading to HTT inclusion formation in the brain. The mutant huntingtin protein (mHTT) is ubiquitously expressed and therefore nuclear inclusions could be present in all brain cells. The effects of nuclear inclusion formation have been mainly studied in neurons, while the effect on glia has been comparatively disregarded. Astrocytes, microglia, and oligodendrocytes are glial cells that are essential for normal brain function and are implicated in several neurological diseases...
September 12, 2016: Glia
P H J van der Voort, B Wilffert, E N van Roon, D R A Uges
No abstract text is available yet for this article.
July 2016: Netherlands Journal of Medicine
Anastasios Mastrokolias, Rene Pool, Eleni Mina, Kristina M Hettne, Erik van Duijn, Roos C van der Mast, GertJan van Ommen, Peter A C 't Hoen, Cornelia Prehn, Jerzy Adamski, Willeke van Roon-Mom
INTRODUCTION: Metabolic changes have been frequently associated with Huntington's disease (HD). At the same time peripheral blood represents a minimally invasive sampling avenue with little distress to Huntington's disease patients especially when brain or other tissue samples are difficult to collect. OBJECTIVES: We investigated the levels of 163 metabolites in HD patient and control serum samples in order to identify disease related changes. Additionally, we integrated the metabolomics data with our previously published next generation sequencing-based gene expression data from the same patients in order to interconnect the metabolomics changes with transcriptional alterations...
2016: Metabolomics: Official Journal of the Metabolomic Society
Maarten R Hillen, Frederique M Moret, Barbara Giovannone, Aike A Kruize, Timothy R D J Radstake, Joel A G van Roon
September 2016: Clinical and Experimental Rheumatology
Eleni Mina, Willeke van Roon-Mom, Kristina Hettne, Erik van Zwet, Jelle Goeman, Christian Neri, Peter A C 't Hoen, Barend Mons, Marco Roos
BACKGROUND: Huntington's disease (HD) is a devastating brain disorder with no effective treatment or cure available. The scarcity of brain tissue makes it hard to study changes in the brain and impossible to perform longitudinal studies. However, peripheral pathology in HD suggests that it is possible to study the disease using peripheral tissue as a monitoring tool for disease progression and/or efficacy of novel therapies. In this study, we investigated if blood can be used to monitor disease severity and progression in brain...
2016: Orphanet Journal of Rare Diseases
Kevin D Roon, Adamantios I Gafos
We offer a dynamical model of phonological planning that provides a formal instantiation of how the speech production and perception systems interact during online processing. The model is developed on the basis of evidence from an experimental task that requires concurrent use of both systems, the so-called response-distractor task in which speakers hear distractor syllables while they are preparing to produce required responses. The model formalizes how ongoing response planning is affected by perception and accounts for a range of results reported across previous studies...
August 2016: Journal of Memory and Language
Alsya A Affandi, Joel A G van Roon
No abstract text is available yet for this article.
July 18, 2016: Arthritis & Rheumatology
Niels Eijkelkamp, Cristine Steen-Louws, Sarita A Y Hartgring, Hanneke L D M Willemen, Judith Prado, Floris P J G Lafeber, Cobi J Heijnen, C E Hack, Joel A G van Roon, Annemieke Kavelaars
UNLABELLED: Chronic pain is a major clinical problem that is difficult to treat and requires novel therapies. Although most pain therapies primarily target neurons, neuroinflammatory processes characterized by spinal cord and dorsal root ganglion production of proinflammatory cytokines play an important role in persistent pain states and represent potential therapeutic targets. Anti-inflammatory cytokines are attractive candidates to regulate aberrant neuroinflammatory processes, but the therapeutic potential of these cytokines as stand-alone drugs is limited...
July 13, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Daniel J Brown, Christopher J Pastras, Ian S Curthoys, Cassandra S Southwell, Lieke Van Roon
There are a variety of techniques available to investigate endolymph dynamics, primarily seeking to understand the cause of endolymphatic hydrops. Here we have taken the novel approach of injecting, via a glass micropipette, fluorescein isothiocyanate-dextran (FITC-dex) and artificial endolymph into scala media of anaesthetized guinea pigs, with subsequent imaging of the inner ear using Light Sheet Fluorescence Microscopy (LSFM) as a means to obtain highly resolved 3D visualization of fluid movements. Our results demonstrate endolymph movement into the utricle, semicircular canals and endolymphatic duct and sac when more than 2...
September 2016: Hearing Research
S Lubberts, H Boer, R Altena, C Meijer, A M van Roon, N Zwart, S F Oosting, P W Kamphuisen, J Nuver, A J Smit, A B Mulder, J D Lefrandt, J A Gietema
BACKGROUND: Metastatic testicular cancer (TC) can be cured with bleomycin, etoposide and cisplatin (BEP) chemotherapy. This comes at the price of an increased cardiovascular disease risk, not only years afterwards, but also during and shortly after chemotherapy. To prevent cardiovascular events, high-risk patients should be identified. The aim of this study was to assess BEP-chemotherapy induced vascular damage and to find risk factors for early vascular events. PATIENTS AND METHODS: A prospective cohort study was performed in (B)EP treated TC patients...
August 2016: European Journal of Cancer
Jing Wang, Alan Saul, Penny Roon, Sylvia B Smith
Retinal degenerative diseases are major causes of untreatable blindness, and novel approaches to treatment are being sought actively. Here we explored the activation of a unique protein, sigma 1 receptor (Sig1R), in the treatment of PRC loss because of its multifaceted role in cellular survival. We used Pde6β(rd10) (rd10) mice, which harbor a mutation in the rod-specific phosphodiesterase gene Pde6β and lose rod and cone photoreceptor cells (PRC) within the first 6 wk of life, as a model for severe retinal degeneration...
June 28, 2016: Proceedings of the National Academy of Sciences of the United States of America
Stefanie A de Boer, Marieke C Hovinga-de Boer, Hiddo J L Heerspink, Joop D Lefrandt, Arie M van Roon, Helen L Lutgers, Andor W J M Glaudemans, Pieter W Kamphuisen, Riemer H J A Slart, Douwe J Mulder
OBJECTIVE: Type 2 diabetes is accompanied by premature atherosclerosis and arterial stiffness. The underlying association remains incompletely understood. The possible relationship between subclinical arterial inflammation assessed by (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and arterial stiffness was investigated in patients with early type 2 diabetes. RESEARCH DESIGN AND METHODS: Patients with type 2 diabetes (n = 44), without cardiovascular disease and any type of antidiabetic medication, were studied (median age 63 years [interquartile range 54-66], men:women 27:17)...
August 2016: Diabetes Care
M R Hillen, F M Moret, Kmg van der Wurff-Jacobs, Trdj Radstake, C E Hack, Fpjg Lafeber, Jag van Roon
OBJECTIVES: Thymus and activation-regulated chemokine (TARC) attracts cells that express the C-C chemokine receptor type 4 (CCR4), including CD4 T cells. As expression of CCR4 is increased on peripheral T cells and intra-articular interleukin (IL)-17-producing cells in patients with rheumatoid arthritis (RA), we investigated whether TARC plays a role in the attraction of T cells to the synovial compartment. In addition, we assessed the role of classical dendritic cells (cDCs) in the production of TARC in RA...
June 2, 2016: Scandinavian Journal of Rheumatology
Kevin D Roon, Katherine M Dawson, Mark K Tiede, D H Whalen
Optical marker tracking integrated with electromagnetic articulometry was used to assess the movement extent of various points on (a) forehead skin and (b) points on a head-mounted apparatus, relative to a fixed point just above the upper incisors, and to compare the accuracy of the two different approaches to indexing head position during speech production. Both methods can provide a satisfactory index of head position. If skin-affixed markers are used, a minimum of 4 is recommended. Locations for optimal marker placement are identified...
May 2016: Journal of the Acoustical Society of America
Ariana Barberá, Noraylis Lorenzo, Peter van Kooten, Joel van Roon, Wilco de Jager, Dinorah Prada, Jorge Gómez, Gabriel Padrón, Willem van Eden, Femke Broere, María Del Carmen Domínguez
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by a chronic relapsing-remitting joint inflammation. Perturbations in the balance between CD4 + T cells producing IL-17 and CD4 + CD25(high)FoxP3 + Tregs correlate with irreversible bone and cartilage destruction in RA. APL1 is an altered peptide ligand derived from a CD4+ T-cell epitope of human HSP60, an autoantigen expressed in the inflamed synovium, which increases the frequency of CD4 + CD25(high)FoxP3+ Tregs in peripheral blood mononuclear cells from RA patients...
July 2016: Cell Stress & Chaperones
Jing Wang, Xuezhi Cui, Penny Roon, Sylvia B Smith
PURPOSE: Sigma receptor 1 (Sigma1R), a nonopioid putative molecular chaperone, has neuroprotective properties in retina. This study sought to determine whether delaying administration of (+)-pentazocine, a high-affinity Sigma1R ligand after onset of diabetes in Ins2Akita/+ diabetic mice would afford retinal neuroprotection and to determine consequences on retinal phenotype in Ins2Akita/+ diabetic mice in the absence of Sigma1R. METHODS: Ins2Akita/+ diabetic and WT mice received intraperitoneal injections of (+)-pentazocine beginning 4 or 8 weeks after onset of diabetes; eyes were harvested at 25 weeks...
May 1, 2016: Investigative Ophthalmology & Visual Science
Jan Peter Yska, Sanneke Gertsen, Gerbrich Flapper, Marloes Emous, Bob Wilffert, Eric N van Roon
BACKGROUND: Use of nonsteroidal anti-inflammatory drugs (NSAIDs) should be avoided in bariatric surgery patients. If use of an NSAID is inevitable, a proton pump inhibitor (PPI) should also be used. AIM: To determine the effect of an, compared to care-as-usual, additional intervention to reduce NSAID use in patients who underwent bariatric surgery, and to determine the use of PPIs in patients who use NSAIDs after bariatric surgery. METHODS: A randomized controlled intervention study in patients after bariatric surgery...
May 12, 2016: Obesity Surgery
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