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Breast cancer radiotherapy

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https://www.readbyqxmd.com/read/28211614/opportunities-for-improving-triple-negative-breast-cancer-outcomes-results-of-a-population-based-study
#1
Elisabetta Rapiti, Kim Pinaud, Pierre O Chappuis, Valeria Viassolo, Aurélie Ayme, Isabelle Neyroud-Caspar, Massimo Usel, Christine Bouchardy
Triple-negative breast cancer (TNBC) is associated with a poor prognosis. Surgery, radiotherapy, chemotherapy, and referral for genetic counseling are the standard of care. We assessed TNBC prevalence, management, and outcome using data from the population-based Geneva cancer registry. 2591 women had a first invasive stage I-III breast cancer diagnosed between 2003 and 2011. We compared TNBC to other breast cancers (OBC) by χ(2) -test and logistic regression. Kaplan-Meier survival curves, up to 31-12-2014, were compared using log-rank test...
February 17, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28208703/androgen-receptor-signaling-in-salivary-gland-cancer
#2
REVIEW
Martin G Dalin, Philip A Watson, Alan L Ho, Luc G T Morris
Salivary gland cancers comprise a small subset of human malignancies, and are classified into multiple subtypes that exhibit diverse histology, molecular biology and clinical presentation. Local disease is potentially curable with surgery, which may be combined with adjuvant radiotherapy. However, metastatic or unresectable tumors rarely respond to chemotherapy and carry a poorer prognosis. Recent molecular studies have shown evidence of androgen receptor signaling in several types of salivary gland cancer, mainly salivary duct carcinoma...
February 8, 2017: Cancers
https://www.readbyqxmd.com/read/28205042/screening-relevant-age-threshold-of-70%C3%A2-years-and-older-is-a-stronger-determinant-for-the-choice-of-adjuvant-treatment-in-breast-cancer-patients-than-tumor-biology
#3
E C Inwald, O Ortmann, M Koller, F Zeman, F Hofstädter, M Evert, G Brockhoff, M Klinkhammer-Schalke
PURPOSE: The 70-year threshold determines whether patients are eligible or not for the breast cancer screening program in Germany. It is not known whether this age threshold also influences the choice of adjuvant treatment and ultimate outcome. METHODS: 3463 patients were analyzed from the clinical cancer registry Regensburg (Germany) with primary, non-metastatic invasive breast cancer diagnosed between 2000 and 2012. The distribution of tumor biological subtypes was evaluated in breast cancer patients both in those eligible for screening (ESG, 50-69 years) and those not eligible for screening (NESG, ≥70 years)...
February 15, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28194811/infundibular-pulmonary-stenosis-after-radiotherapy-for-breast-cancer
#4
Makoto Hashimoto, Ryuji Koshima, Hirosato Doi, Keijiro Mitsube
Postoperative radiotherapy for breast cancer may be associated with cardiotoxicity. We present a case of acquired infundibular pulmonary stenosis that developed 43 years after radiotherapy for left breast cancer, which necessitated a right ventricular outflow tract myectomy.
February 14, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/28193571/outcomes-and-utilization-of-postmastectomy-radiotherapy-for-t3n0-breast-cancers
#5
Samual R Francis, Jonathan Frandsen, Kristine E Kokeny, David K Gaffney, Matthew M Poppe
BACKGROUND: The role of postmastectomy radiotherapy (PMRT) for women with pT3N0M0 breast cancer is controversial. We sought to determine the benefit of PMRT in this cohort using the National Cancer Database (NCDB). METHODS: We analyzed women with pT3N0M0 breast cancer who received mastectomy with or without PMRT between 2004 and 2012. We excluded men, women ≤18 years, neoadjuvant or unknown radiation or chemotherapy status, unknown estrogen or progesterone receptor status, unknown surgical margin status, histology other than invasive ductal or lobular carcinoma, and if death occurred <3 months after diagnosis...
February 9, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28193310/depressive-symptoms-and-inflammation-are-independent-risk-factors-of-fatigue-in-breast-cancer-survivors
#6
C Xiao, A H Miller, J Felger, D Mister, T Liu, M A Torres
BACKGROUND: Psychosocial and inflammatory factors have been associated with fatigue in breast cancer survivors. Nevertheless, the relative contribution and/or interaction of these factors with cancer-related fatigue have not been well documented. METHOD: This cross-sectional study enrolled 111 stage 0-III breast cancer patients treated with breast surgery followed by whole breast radiotherapy. Fatigue was measured by the total score of the Multidimensional Fatigue Inventory-20...
February 14, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28192598/overall-survival-and-the-response-to-radiotherapy-among-molecular-subtypes-of-breast-cancer-brain-metastases-treated-with-targeted-therapies
#7
Jacob A Miller, Rupesh Kotecha, Manmeet S Ahluwalia, Alireza M Mohammadi, Samuel T Chao, Gene H Barnett, Erin S Murphy, Michael A Vogelbaum, Lilyana Angelov, David M Peereboom, John H Suh
BACKGROUND: The current study was conducted to investigate survival and the response to radiotherapy among patients with molecular subtypes of breast cancer brain metastases treated with or without targeted therapies. METHODS: Patients diagnosed with breast cancer brain metastases at a single tertiary care institution were included. The primary outcome was overall survival, whereas secondary outcomes included the cumulative incidences of distant intracranial failure, local failure, and radiation necrosis...
February 13, 2017: Cancer
https://www.readbyqxmd.com/read/28191337/effects-of-swedish-massage-on-the-improvement-of-mood-disorders-in-women-with-breast-cancer-undergoing-radiotherapy
#8
Sara Darabpour, Masoomeh Kheirkhah, Erfan Ghasemi
BACKGROUND: Breast cancer is the most common cancer in women, and the second leading cause of cancer deaths. The detection and treatment of this cancer may create mental pressure and lower mood levels, causing anxiety, depression, stress, and pain for the patients. OBJECTIVES: The aim of this study was to determine the effects of Swedish massage on mood disorders in breast cancer patients undergoing radiotherapy at the cancer institute of the Imam Khomeini hospital at the Tehran University of Medical Sciences...
November 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28189100/the-impact-of-exercise-during-adjuvant-radiotherapy-for-breast-cancer-on-fatigue-and-quality-of-life-a-systematic-review-and-meta-analysis
#9
REVIEW
Andrea Lipsett, Sarah Barrett, Fatimah Haruna, Karen Mustian, Anita O'Donovan
PURPOSE: Adjuvant radiation therapy (RT) in breast cancer treatment has been proven to enhance outcome, improving recurrence and mortality rates. RT, however, gives rise to unfavourable side-effects, fatigue the most frequent. The aim of this study was to assess the effect of exercise (and different exercise prescription parameters) during adjuvant RT on fatigue among breast cancer patients. Quality of life was a secondary outcome. SEARCH METHODOLOGY AND SELECTION CRITERIA: Randomised controlled trials that investigated the effect of exercise during adjuvant RT on fatigue for breast cancer patients were searched using MEDLINE, EMBASE, Google Scholar, CINAHL, AMED and ClinicalTrials...
February 8, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28188567/breast-cancer-patients-perceptions-of-a-virtual-learning-environment-for-pretreatment-education
#10
Yobelli Alexandra Jimenez, Wei Wang, Kirsty Stuart, Steven Cumming, David Thwaites, Sarah Lewis
The process and technicalities of radiation therapy (RT) for cancer treatment can be challenging for patients to understand as RT involves complex procedures, highly specialised equipment, and radiation itself has limited sensory characteristics. Hence, it is imperative that education programs are specifically planned and developed to suit the needs of patients, address radiation as an entity and include salient visual aids. In this context, the Virtual Environment for Radiotherapy Training (VERT) system, primarily created for RT practitioner simulation, may provide unique opportunities for patient education...
February 10, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28186846/in-vitro-mouse-and-human-serum-stability-of-a-heterobivalent-dual-target-probe-that-has-strong-affinity-to-gastrin-releasing-peptide-and-neuropeptide-y1-receptors-on-tumor-cells
#11
Arijit Ghosh, Natarajan Raju, Michael Tweedle, Krishan Kumar
Receptor-targeting radiolabeled molecular probes with high affinity and specificity are useful in studying and monitoring biological processes and responses. Dual- or multiple-targeting probes, using radiolabeled metal chelates conjugated to peptides, have potential advantages over single-targeting probes as they can recognize multiple targets leading to better sensitivity for imaging and radiotherapy when target heterogeneity is present. Two natural hormone peptide receptors, gastrin-releasing peptide (GRP) and Y1, are specifically interesting as their expression is upregulated in most breast and prostate cancers...
February 2017: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28185165/oncolytic-viruses-emerging-options-for-the-treatment-of-breast-cancer
#12
REVIEW
Yogesh R Suryawanshi, Tiantian Zhang, Karim Essani
Breast cancer (BC) is the most common type of cancer among women and is the second most common cause of cancer-related deaths, following lung cancer. Severe toxicity associated with a long-term use of BC chemo- and radiotherapy makes it essential to look for newer therapeutics. Additionally, molecular heterogeneity at both intratumoral and intertumoral levels among BC subtypes is known to result in a differential response to standard therapeutics. Oncolytic viruses (OVs) have emerged as one of the most promising treatment options for BC...
March 2017: Medical Oncology
https://www.readbyqxmd.com/read/28181128/effects-of-exercise-on-sleep-problems-in-breast-cancer-patients-receiving-radiotherapy-a-randomized-clinical-trial
#13
Karen Steindorf, Joachim Wiskemann, Cornelia M Ulrich, Martina E Schmidt
PURPOSE: Sleep problems frequently affect breast cancer patients during and after treatment and reduce their quality of life. Treatment strategies are mostly unknown. Thus, we assessed within a randomized controlled trial whether a 12-week exercise program starting with the radiotherapy influences sleep trajectories. METHODS: Sleep quality and problems were assessed via self-report in 160 breast cancer patients before, during, and 2, 6, and 12 months after participation in a trial investigating resistance exercise versus a relaxation control group concomitant with radiotherapy...
February 8, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28179964/prognostic-impact-of-the-tumor-marker-ca-15-3-in-patients-with-breast-cancer-and-bone-metastases-treated-with-palliative-radiotherapy
#14
Carsten Nieder, Astrid Dalhaug, Ellinor Haukland, Bard Mannsaker, Adam Pawinski
BACKGROUND: The aim of the study was to explore the prognostic impact of different abnormal blood tests and the tumor marker CA 15-3 as well as established parameters such as disease extent and receptor status in patients with bone metastases from breast cancer who received palliative radiotherapy in addition to contemporary systemic treatment. METHODS: This was a retrospective uni- and multivariate analysis of 118 female patients treated in the time period from 2007 to 2014 (median follow-up 28 months)...
March 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28179347/dose-sparing-potential-of-deep-inspiration-breath-hold-technique-for-left-breast-cancer-radiotherapy-organs-at-risk
#15
Gavin Lawler, Michelle Leech
BACKGROUND/AIM: To assess if deep inspiration breath-hold (DIBH) technique achieved dose sparing for organs-at-risk in left breast radiotherapy patients in order to reduce long-term complications. PATIENTS AND METHODS: DIBH and Free-breathing (FB) as a control, CT planning scans obtained for 28 left breast/chest wall (+/- supraclavicular field) patients treated January 2008-December 2013 were retrospectively re-contoured and re-planned. Organs-at-risk examined: lungs, left lung, heart and left anterior descending coronary artery (LADCA)...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28178709/neoplastic-meningitis-due-to-lung-breast-and-melanoma-metastases
#16
Emilie Le Rhun, Sophie Taillibert, Marc C Chamberlain
BACKGROUND: Neoplastic meningitis, a central nervous system (CNS) complication of cancer metastatic to the meninges and cerebrospinal fluid (CSF), is relevant to oncologists due to the impact of the disease on patient quality of life and survival rates. METHODS: A review of the literature of articles published in English was conducted with regard to neoplastic meningitis. RESULTS: The incidence of neoplastic meningitis is increasing because patients with cancer are surviving longer in part because of the use of novel therapies with poor CNS penetration...
January 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28178355/effects-of-exercise-training-on-circulating-levels-of-dickkpof-1-and-secreted-frizzled-related-protein-1-in-breast-cancer-survivors-a-pilot-single-blind-randomized-controlled-trial
#17
Tae Ho Kim, Jae Seung Chang, Kyu-Sang Park, Jeeyeon Park, Nahyun Kim, Jong In Lee, In Deok Kong
BACKGROUND: Wingless and integration site growth factor (Wnt) signaling is a tumorigenesis-related signaling pathway. Dickkpof-1 (DKK1) and secreted frizzled-related protein-1 (SFRP1) are endogenous negative regulators of Wnt/β-catenin signaling. Accumulating evidence indicates that higher serum levels of DKK1 are correlated with poor prognosis of various types of cancer. Here, we investigated whether exercise training causes changes in the serum levels of DKK1 and SFRP1 in patients with breast cancer...
2017: PloS One
https://www.readbyqxmd.com/read/28176303/association-between-age-and-access-to-immediate-breast-reconstruction-in-women-undergoing-mastectomy-for-breast-cancer
#18
R Jeevan, J P Browne, C Gulliver-Clarke, J Pereira, C M Caddy, J H P van der Meulen, D A Cromwell
BACKGROUND: National guidelines state that patients with breast cancer undergoing mastectomy in England should be offered immediate breast reconstruction (IR), unless precluded by their fitness for surgery or the need for adjuvant therapies. METHODS: A national study investigated factors that influenced clinicians' decision to offer IR, and collected data on case mix, operative procedures and reconstructive decision-making among women with breast cancer having a mastectomy with or without IR in the English National Health Service between 1 January 2008 and 31 March 2009...
February 8, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28166138/postmastectomy-breast-reconstruction-combined-with-contralateral-breast-augmentation-for-taiwanese-women-with-small-breasts
#19
Hung-Hui Liu, I-Han Chiang, Chih-Hsin Wang, Hao-Yu Chiao, Chang-Yi Chou, Chi-Yu Wang, Yuan-Sheng Tzeng, Tim-Mo Chen, Shyi-Gen Chen
BACKGROUND: Although autogenous tissue-based breast reconstruction has been widely used in the past decade, implant-based breast reconstruction is more often used in Taiwan because Asian women are generally slender with small breasts. For patients with very small breasts, it is hard to achieve the goal of reconstructing a similar breast to the contralateral one, even with the smallest size implant available commercially. Therefore, these patients need not only breast reconstruction but also contralateral breast augmentation...
February 4, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28164759/neoadjuvant-therapy-for-her2-positive-breast-cancer
#20
Rachel Wuerstlein, Nadia Harbeck
In HER2-positive early breast cancer, neoadjuvant treatment with a combination of sequential chemotherapy and HER2-targeted therapy is currently the standard of care. This is followed by breast surgery, radiotherapy (if indicated), completion of 12 months of HER2-directed therapy, and -depending on the tumor biology - endocrine adjuvant therapy, and ultimately follow up. 10-year survival rates in the HER2-positive subgroup of breast cancer do reach now more than 75% with the introduction of first adjvuant and later neoadjuvant HER2-targeted therapies over the last 15 years...
February 2, 2017: Reviews on Recent Clinical Trials
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