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Lupus scleroderma vasculitis

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https://www.readbyqxmd.com/read/27833788/vasculitic-diseases-and-prothrombotic-states-contributing-to-delayed-healing-in-chronic-wounds
#1
Victoria K Shanmugam
PURPOSE: Autoimmune diseases are a common cause of delayed wound healing and should be considered in patients with chronic wounds who do not respond to local wound care or who fail skin grafting in the absence of infection. RECENT FINDINGS: Epidemiologic studies have shown that, of patients with chronic wounds evaluated in specialized wound healing clinics, 20-23% have autoimmune etiologies for their wounds including vasculitis, rheumatoid arthritis, systemic lupus erythematosus, scleroderma, pyoderma gangrenosum and other autoimmune diseases...
December 2016: Current Dermatology Reports
https://www.readbyqxmd.com/read/27826170/rheumatic-diseases-induced-by-drugs-and-environmental-factors-the-state-of-the-art-part-two
#2
REVIEW
Karolina Niklas, Arkadiusz A Niklas, Dominik Majewski, Mariusz J Puszczewicz
The majority of rheumatic diseases belong to the group of autoimmune diseases and are associated with autoantibody production. Their etiology is not fully understood. Certain medications and environmental factors may have an influence on the occurrence of rheumatic diseases. Establishing a cause-effect relationship between a certain factor and disease induction is not always simple. It is important to administer the drug continuously or monitor exposure to a given factor in the period preceding the onset of symptoms...
2016: Reumatologia
https://www.readbyqxmd.com/read/27796482/-therapeutic-administration-of-immunoglobulins
#3
T Witte
BACKGROUND: Intravenously administered immunoglobulins have multiple modes of action that are anti-inflammatory. They can therefore be beneficial in a number of autoimmune disorders. OBJECTIVE: The aim of this article is to analyze and summarize studies on the administration of intravenous immunoglobulins in rheumatological diseases. METHODS: A selective search and analysis of the literature was carried out related to the mode of action and efficacy of intravenous immunoglobulins in rheumatological diseases...
December 2016: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/27504022/rheumatic-diseases-induced-by-drugs-and-environmental-factors-the-state-of-the-art-part-one
#4
REVIEW
Karolina Niklas, Arkadiusz A Niklas, Dominik Majewski, Mariusz Puszczewicz
The majority of rheumatic diseases belong to the group of autoimmune diseases and are associated with autoantibody production. Their etiology is not fully understood. Certain medications and environmental factors may have an influence on the occurrence of rheumatic diseases. Establishing a cause-effect relationship between a certain factor and disease induction is not always simple. It is important to administer the drug continuously or monitor exposure to a given factor in the period preceding the onset of symptoms...
2016: Reumatologia
https://www.readbyqxmd.com/read/27390939/left-ventricular-diastolic-dysfunction-and-increased-left-ventricular-mass-index-related-to-pulmonary-hypertension-in-patients-with-systemic-autoimmune-disease-without-pericardial-effusion
#5
Atsushi Sugiura, Nobusada Funabashi, Koya Ozawa, Yoshio Kobayashi
PURPOSE: We investigated the relationship of left ventricular (LV) diastolic dysfunction and LV mass index (LVMI) against pulmonary hypertension (PH) in systemic autoimmune disease (SAD). METHODS: A total of 84 SAD patients (68 females; 53±17years; systemic lupus erythematosus, 27%; scleroderma, 17%; vasculitis, 16%; mixed connective tissue disease, 13% and polymyositis/dermatomyositis complex, 10%) without significant pericardial effusion (PE) on TTE (Vivid E9, GE) were analyzed...
October 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27179903/cardiovascular-magnetic-resonance-in-rheumatology-current-status-and-recommendations-for-use
#6
REVIEW
Sophie I Mavrogeni, George D Kitas, Theodoros Dimitroulas, Petros P Sfikakis, Philip Seo, Sherine Gabriel, Amit R Patel, Luna Gargani, Stefano Bombardieri, Marco Matucci-Cerinic, Massimo Lombardi, Alessia Pepe, Anthony H Aletras, Genovefa Kolovou, Tomasz Miszalski, Piet van Riel, AnneGrete Semb, Miguel Angel Gonzalez-Gay, Patrick Dessein, George Karpouzas, Valentina Puntmann, Eike Nagel, Konstantinos Bratis, Georgia Karabela, Efthymios Stavropoulos, Gikas Katsifis, Loukia Koutsogeorgopoulou, Albert van Rossum, Frank Rademakers, Gerald Pohost, Joao A C Lima
Targeted therapies in connective tissue diseases (CTDs) have led to improvements of disease-associated outcomes, but life expectancy remains lower compared to general population due to emerging co-morbidities, particularly due to excess cardiovascular risk. Cardiovascular magnetic resonance (CMR) is a noninvasive imaging technique which can provide detailed information about multiple cardiovascular pathologies without using ionizing radiation. CMR is considered the reference standard for quantitative evaluation of left and right ventricular volumes, mass and function, cardiac tissue characterization and assessment of thoracic vessels; it may also be used for the quantitative assessment of myocardial blood flow with high spatial resolution and for the evaluation of the proximal coronary arteries...
August 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27169551/clinical-scenarios-in-chronic-kidney-disease-parenchymal-chronic-renal-diseases-part-2
#7
Ilaria Petrucci, Sara Samoni, Mario Meola
Secondary nephropathies can be associated with disreactive immunological disorders or with a non-inflammatory glomerular damage. In systemic lupus erythematosus (SLE), scleroderma and rheumatoid arthritis as in other connective tissue diseases, kidney volume and cortex echogenicity are the parameters that best correlate with clinical severity of the disease, even if the morphological aspect is generally non-specific. Doppler studies in SLE document the correlation between resistance indexes (RIs) values and renal function...
2016: Contributions to Nephrology
https://www.readbyqxmd.com/read/27149461/cancer-risk-in-patients-with-inflammatory-systemic-autoimmune-rheumatic-diseases-a-nationwide-population-based-dynamic-cohort-study-in-taiwan
#8
Kuang-Hui Yu, Chang-Fu Kuo, Lu Hsiang Huang, Wen-Kuan Huang, Lai-Chu See
The aim of this study was to determine whether inflammation is related to cancer development, and whether the incidence of cancer is increased and occurs in a site-specific manner in patients with systemic autoimmune rheumatic diseases (SARDs).This study included a nationwide dynamic cohort of patients with various newly diagnosed SARDs from 1997 to 2010 with follow-up until 2012.This study included 75,123 patients with SARDs. During 562,870 person-years of follow-up, 2844 patients developed cancer. Between 1997 and 2010, the highest number of newly diagnosed SARDs cases were rheumatoid arthritis (n = 35,182), followed by systemic lupus erythematosus (SLE, n = 15,623), Sjögren syndrome (n = 11,998), Kawasaki disease (n = 3469), inflammatory bowel disease (n = 2853), scleroderma (n = 1814), Behçet disease (n = 1620), dermatomyositis (n = 1119), polymyositis (n = 811), and vasculitis other than Kawasaki disease (n = 644)...
May 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27131766/immunological-and-inflammatory-processes-in-systemic-autoimmune-disease-may-not-only-cause-pericardium-inflammation-but-may-also-cause-mitral-valve-deterioration-and-left-ventricular-wall-thickening
#9
Atsushi Sugiura, Nobusada Funabashi, Koya Ozawa, Yoshio Kobayashi
PURPOSE: Systemic autoimmune disease (SAD) frequently affects the pericardium, and pathology is characterized by both immunological and inflammatory processes. We hypothesized that these processes simultaneously influence mitral-valve (MV) deterioration and left-ventricular (LV) wall thickening in SAD subjects. METHODS: 101 SAD subjects were selected (76 female; 53±17years; systemic-lupus-erythematosus, 26%; vasculitis, 20%; scleroderma, 14%; polymyositis/dermatomyositis complex, 10%; mixed connective tissue disease, 11% and rheumatoid-arthritis, 2%)...
July 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/26831786/-screening-for-potential-drug-targets-by-comprehensive-identification-of-disease-specific-antigens-incorporated-into-immune-complexes-in-patients-with-immunological-diseases
#10
Kaname Ohyama
Our immune system resembles an intelligent security system, which continually monitors for foreign invaders (infectious diseases); however, in some cases, this system recognizes healthy parts as something harmful or foreign and then attacks them (autoimmune diseases). The defining characteristics of an autoimmune disease are the existence of T- and B-cell autoreactivity against self proteins (autoantigens). In addition to autoimmune diseases, aberrant host proteins that occur during a certain state of diseases (e...
2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/26698837/melkersson-rosenthal-syndrome-as-an-early-manifestation-of-mixed-connective-tissue-disease
#11
Dorota Jasinska, Jerzy Boczon
PURPOSE OF REVIEW: We aim to illustrate the potential viability of MCTD as an underlying aetiology of Melkersson-Rosenthal syndrome. The case is probably the first description available in the literature of the Melkersson-Rosenthal as an early manifestation of mixed connective tissue disease. RECENT FINDINGS: The Melkersson-Rosenthal syndrome consists of a triad of recurrent lip and/or face swelling, fissured tongue, and intermittent facial palsy. Mixed connective tissue disease is a multisystemic disorder with overlapping features of systemic lupus erythematosus, scleroderma, and polymyositis, and is differentiated from them by a high titer of antibodies to ribonucleoprotein...
December 23, 2015: European Journal of Medical Research
https://www.readbyqxmd.com/read/26166493/immune-complexome-analysis-of-antigens-in-circulating-immune-complexes-isolated-from-patients-with-igg4-related-dacryoadenitis-and-or-sialadenitis
#12
Kaname Ohyama, Miyako Baba, Mami Tamai, Motohisa Yamamoto, Kunihiro Ichinose, Naoya Kishikawa, Hiroki Takahashi, Atsushi Kawakami, Naotaka Kuroda
OBJECTIVES: IgG4-related disease (IgG4-RD) is characterized by various serological abnormalities. Some patients with IgG4-RD present with hypergammaglobulinemia, hypocomplementemia, and autoantibodies recognizing rheumatoid factors and nuclear factors. However, whether IgG4-RD is an autoimmune disease remains unclear. METHODS: Here, we used immune complexome analysis to comprehensively identify constituent antigens of circulating immune complexes isolated from 10 patients with IgG4-related dacryoadenitis and/or sialadenitis (IgG4-RDS) which is one condition associated with IgG4-RD...
2016: Modern Rheumatology
https://www.readbyqxmd.com/read/26065913/humoral-responses-to-diverse-autoimmune-disease-associated-antigens-in-multiple-sclerosis
#13
Kishore Malyavantham, Bianca Weinstock-Guttman, Lakshmanan Suresh, Robert Zivadinov, Thomas Shanahan, Darlene Badgett, Murali Ramanathan
UNLABELLED: To compare frequencies of autoreactive antibody responses to endogenous disease-associated antigens in healthy controls (HC), relapsing and progressive MS and to assess their associations with clinical and MRI measures of MS disease progression. METHODS: The study analyzed 969 serum samples from 315 HC, 411 relapsing remitting MS (RR-MS), 128 secondary progressive MS (SP-MS), 33 primary progressive MS (PP-MS) and 82 patients with other neurological diseases for autoantibodies against two putative MS antigens CSF114(Glc) and KIR4...
2015: PloS One
https://www.readbyqxmd.com/read/25962452/-prognosis-and-therapy-of-inflammatory-rheumatic-diseases-impact-of-renal-manifestations
#14
REVIEW
M Zänker, C D Cohen, H D Rupprecht
BACKGROUND: Inflammatory rheumatic diseases and their treatment cause various renal manifestations requiring modification of treatment. OBJECTIVES: Discussion of renal manifestations in selected rheumatic diseases, including their impact on general prognosis and therapy. MATERIALS AND METHODS: Basic literature and expert opinions are analyzed and discussed. RESULTS: Inflammatory rheumatic diseases and their treatment cause various renal manifestations, including glomerular, tubular, interstitial, and vascular damage...
May 2015: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/25786676/clinical-aspects-of-indirect-immunofluorescence-for-autoimmune-diseases
#15
REVIEW
Alireza Ghanadan, Amene Saghazadeh, Issa Jahanzad, Nima Rezaei
Because the most common term used in conversations considering autoimmunity is autoantibodies, it is well-expected that the indirect immunofluorescence assay, which detects antibodies directed against various antigens, is one of our most impressive techniques for investigating autoimmune diseases (AIDs). Roughly speaking, the current literature corroborates that this immunopathologic investigation means that autoantibodies detection makes a considerable contribution to both diagnostic and prognostic aspects of AIDs in the clinical setting...
May 2015: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/25455357/connective-tissue-disorders-associated-with-vasculitis-and-vaso-occlusive-disease-of-the-hand
#16
REVIEW
Brett Michelotti, Marco Rizzo, Steven L Moran
Hand ischemia caused by vasculitis is a secondary finding in many autoimmune processes. Many of these autoimmune diseases are managed primarily with medications that can prevent the development of occlusive disease, tissue ischemia, and tissue loss. Unfortunately several disease conditions can be recalcitrant to medical management and can result in ischemic changes within the hand, which may require operative intervention. This article briefly reviews the major connective tissue disorders associated with vasculitis and vaso-occlusive disease of the hand, including scleroderma, lupus, and Buerger disease, and their surgical treatment...
February 2015: Hand Clinics
https://www.readbyqxmd.com/read/25438073/proteomic-profiling-of-antigens-in-circulating-immune-complexes-associated-with-each-of-seven-autoimmune-diseases
#17
Kaname Ohyama, Miyako Baba, Mami Tamai, Nozomi Aibara, Kunihiro Ichinose, Naoya Kishikawa, Atsushi Kawakami, Naotaka Kuroda
OBJECTIVE: Immune complexes (ICs) trigger humoral immune responses. Therefore, the identification of constituent antigens within ICs would have very different clinical significance than identification of free antigens. DESIGN AND METHODS: Here, we applied immune complexome analysis of serum to the study of seven major autoimmune diseases-anti-neutrophil cytoplasmic antibody-associated vasculitis, Takayasu's arteritis, mixed connective tissue disease, dermatomyositis, Sjögren's syndrome, systemic scleroderma, and systemic lupus erythematosus-and healthy donors to comprehensively identify antigens incorporated into circulating ICs and to find disease-specific antigens...
February 2015: Clinical Biochemistry
https://www.readbyqxmd.com/read/25307291/association-of-anti-acidic-ribosomal-protein-p0-and-anti-galectin-3-antibodies-with-the-development-of-skin-lesions-in-systemic-lupus-erythematosus
#18
Zhen-Rui Shi, Guo-Zhen Tan, Zhen Meng, Min Yu, Kai-Wen Li, Jing Yin, Kai-Hua Wei, Yi-Jin Luo, Shu-Qing Jia, Shu-Juan Zhang, Jian Wu, Xiang-Bin Mi, Liangchun Wang
OBJECTIVE: The specific autoantibodies and antigens that mediate systemic lupus erythematosus (SLE)-related organ injuries remain largely unknown. This study was undertaken to investigate the antibody-mediated immune response that leads to SLE skin lesions. METHODS: The study included 85 SLE patients with lupus-specific skin lesions and 31 without skin lesions. The reactivity of serum antibody with skin antigens was determined by immunoblotting using human foreskin as the substrate...
January 2015: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/25004825/granuloma-annularis-revealing-wegener%C3%A2-s-granulomatosis
#19
F Del Porto, M Proietta, M Muscianese, F Tamburi, N Cifani, L Ferri, S Nistico', U Bottoni, G Bruno, G Pranteda
Skin manifestations are often associated with systemic autoimmune diseases (SAD). Some SAD, such as systemic lupus erythematosus, psoriatic arthritis and scleroderma display pathognomonic dermatological features, whereas other systemic diseases such as sarcoidosis, vasculitis and rheumatoid arthritis can present with non-specific skin manifestations that range from erythema nodosum to necrotic lesions. Here we report the case of a 25-year-old man with uveitis, polyarthrirtis, pulmonary involvement, nephrotic syndrome, cutaneous granuloma and pneumonia by E...
July 2010: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/24809534/extrahepatic-autoimmune-conditions-associated-with-primary-biliary-cirrhosis
#20
REVIEW
Annarosa Floreani, Irene Franceschet, Nora Cazzagon, Alice Spinazzè, Alessandra Buja, Patrizia Furlan, Vincenzo Baldo, M Eric Gershwin
There is a paucity of information on extrahepatic autoimmune (EHA) conditions associated with primary biliary cirrhosis (PBC) and on the impact of EHA conditions on PBC patients' survival. Our goal was to assess the association between PBC and other autoimmune diseases and the impact of EHA conditions on the natural history of PBC. We took advantage of 361 consecutive PBC patients enrolled between 1975 and 2012 (22 males, 339 females; mean follow-up 8 ± 6.9 years). Any associated EHA conditions, PBC histological stage at diagnosis, biochemical data, physiological history, and extrahepatic malignancies developing during the follow-up were recorded...
June 2015: Clinical Reviews in Allergy & Immunology
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