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Somatic experiencing

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https://www.readbyqxmd.com/read/28221868/somatic-brca1-2-recovery-as-a-resistance-mechanism-after-exceptional-response-to-poly-adp-ribose-polymerase-inhibition
#1
Stephanie Lheureux, Jeff P Bruce, Julia V Burnier, Katherine Karakasis, Patricia A Shaw, Blaise A Clarke, S Y Cindy Yang, Rene Quevedo, Tiantian Li, Mark Dowar, Valerie Bowering, Trevor J Pugh, Amit M Oza
Purpose Durable and long-term responses to the poly (ADP-ribose) polymerase inhibitor olaparib are observed in patients without BRCA1/2 mutations. However, beyond BRCA1/2 mutations, there are no approved biomarkers for olaparib in high-grade serous ovarian cancer (HGSOC). To determine mechanisms of durable response and resistance to olaparib therapy, we performed an analysis of HGSOC tumors from three patients without germline BRCA1/2 mutations who experienced exceptional responses to olaparib. Patients and Methods We performed integrated exome, low-pass genome, and RNA sequence analysis of tumors at diagnosis and upon relapse from patients with platinum-sensitive HGSOC recurrence who were treated > 5 years with olaparib therapy as a single agent...
February 21, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28220549/somatic-psychological-and-sexual-triggers-for-overactive-bladder-syndrome-in-women
#2
Ariel Zilberlicht, Nir Haya, Ido Feferkorn, Eyal Goldschmidt, Anis Kaldawy, Yoram Abramov
AIMS: Patients with overactive bladder (OAB) often describe somatic, psychological, and sexual triggers for their symptoms. The aim of this study was to characterize these triggers and assess their impact on patients' symptoms and quality of life (QoL). METHODS: Patients who visited our urogynecologic clinic between August 2015 and March 2016 and diagnosed with OAB syndrome were asked to fill a questionnaire comprising 34 statements regarding SOmatic, Psychological, and Sexual Triggers for OAB (SOPSETO)...
February 21, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28212507/higher-severity-of-cocaine-addiction-is-associated-with-tactile-and-somatic-hallucinations
#3
C Roncero, L Grau-López, R F Palma-Álvarez, L Rodriguez-Cintas, E Ros-Cucurull, A Esojo, C Daigre
BACKGROUND: The aim of this study is to describe the features of cocaine-dependent patients who have had cocaine-induced tactile/somatic hallucinations (CITSH), and to analyze the association with addiction-related variables and psychiatric comorbidity, comparing patients with CITSH, patients with cocaine psychotic symptoms (CIP) and no CITSH, and patients without any psychotic symptom. METHOD: A cross-sectional study was conducted in 767 cocaine-dependent patients in an outpatient treatment center for addictions...
December 1, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28211557/associations-of-selected-lower-urinary-tract-symptoms-with-biographical-context-in-patients-of-a-day-hospital-for-neurotic-disorders
#4
Michał Skalski, Jerzy A Sobański, Tomasz Golabek, Agata Świerkosz, Katarzyna Klasa, Mikołaj Przydacz, Krzysztof Rutkowski, Edyta Dembińska, Michał Mielimąka, Katarzyna Cyranka, Piotr Chłosta, Dominika Dudek
OBJECTIVES: To assess the correlation of subjectively estimated biographical context and lower urinary tract symptoms reported by patients with neurotic and personality disorders. METHODS: This was a retrospective analysis of the biographical context of co-existence of urinary frequency and urinary incontinence reported by 3,929 patients in a day hospital for treatment of neurotic disorders. The symptom checklists KO "0" were completed by patients prior to any treatment...
December 23, 2016: Psychiatria Polska
https://www.readbyqxmd.com/read/28210809/growth-dynamics-of-juvenile-loggerhead-sea-turtles-undergoing-an-ontogenetic-habitat-shift
#5
Matthew D Ramirez, Larisa Avens, Jeffrey A Seminoff, Lisa R Goshe, Selina S Heppell
Ontogenetic niche theory predicts that individuals may undergo one or more changes in habitat or diet throughout their lifetime to maintain optimal growth rates, or to optimize trade-offs between mortality risk and growth. We combine skeletochronological and stable nitrogen isotope (δ(15)N) analyses of sea turtle humeri (n = 61) to characterize the growth dynamics of juvenile loggerhead sea turtles (Caretta caretta) during an oceanic-to-neritic ontogenetic shift. The primary objective of this study was to determine how ontogenetic niche theory extends to sea turtles, and to individuals with different patterns of resource use (discrete shifters, n = 23; facultative shifters n = 14; non-shifters, n = 24)...
February 16, 2017: Oecologia
https://www.readbyqxmd.com/read/28193311/voluntary-and-involuntary-imagery-in-social-anxiety
#6
Sophie R Homer, Catherine Deeprose
BACKGROUND: Negative mental imagery is ubiquitous in cognitive models of social anxiety and in the social anxiety literature. Previous research has shown that it is causal of increased anxiety, lower social performance ratings and lower implicit self-esteem. Despite its prevalence, few studies have investigated this imagery directly. AIMS: This study aimed to provide an in-depth analysis of the phenomenology of negative imagery experienced by socially anxious individuals, and to compare recurrent and intrusive images with images deliberately generated by participants during the study...
February 14, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28166420/does-early-life-trauma-affect-how-depression-is-experienced-by-holocaust-survivors-in-late-life
#7
Norm O'Rourke, Sara Carmel, Yaacov G Bachner
OBJECTIVES: Existing research indicates that early life trauma increases the likelihood of depression in later life. This includes children who survived the Nazi Holocaust living in Israel today. For this study, we set out to examine whether early life trauma affects both levels of depression symptomatology and the relative prominence of certain facets of depression as compared to other older adults in Israel and Canada. METHOD: For this study we recruited 295 Holocaust survivors (HS), 205 other Israelis and 335 older Canadians each of whom completed Radloff's (1977) Center for Epidemiological Studies - Depression Scale (CES-D)...
February 6, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28149428/analysis-of-tests-evaluating-sport-climbers-strength-and-isometric-endurance
#8
Mariusz Ozimek, Robert Staszkiewicz, Robert Rokowski, Arkadiusz Stanula
The present study was designed to determine which types of specific tests provide an effective evaluation of strength and endurance in highly trained competitive sport climbers. The research process consisted of three basic components: the measurement of selected somatic characteristics of the climbers, the assessment of their physical conditioning, and a search for correlations between the anthropometric and "conditioning" variables on the one hand, and climber's performance on the other. The sample of subjects consisted of 14 experienced volunteer climbers capable of handling 7a- 8a+/b on-sight rock climbing grades...
December 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28146566/general-practitioners-attitudes-towards-essential-competencies-in-end-of-life-care-a-cross-sectional-survey
#9
Stéphanie Giezendanner, Corinna Jung, Hans-Ruedi Banderet, Ina Carola Otte, Heike Gudat, Dagmar M Haller, Bernice S Elger, Elisabeth Zemp, Klaus Bally
BACKGROUND: Identifying essential competencies in end-of-life care, as well as general practitioners' (GPs) confidence in these competencies, is essential to guide training and quality improvement efforts in this domain. AIM: To determine which competencies in end-of-life care are considered important by GPs, to assess GPs' confidence in these competencies in a European context and their reasons to refer terminally ill patients to a specialist. DESIGN AND SETTING: Cross-sectional postal survey involving a stratified random sample of 2000 GPs in Switzerland in 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28141730/-footprints-in-the-bathroom-the-role-of-spirituality-in-patient-diagnosis
#10
Veronica Meneses, Douglas Vanderbilt, Linda Barnes, Marilyn Augustyn
Lucy is a 12-year-old Latina whose mother brought her to the pediatric clinic for help with her anxiety symptoms, "hearing voices," and episodes of "spacing out." Lucy did not cry at birth secondary to vocal cord paralysis and still has the tracheostomy performed at a few days of life. In addition to her neonatal intensive care unit stay, she has been hospitalized for pneumonia. Her mother says she is "sickly" and has a weak immune system due to her asthma symptoms. Lucy also experiences somatic complaints related to gastroesophageal reflux and constipation...
February 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28134008/prioritising-patient-care
#11
Helge Skirbekk, Marit Helene Hem, Per Nortvedt
BACKGROUND: There is little research comparing clinicians' and managers' views on priority settings in the healthcare services. During research on two different qualitative research projects on healthcare prioritisations, we found a striking difference on how hospital executive managers and clinical healthcare professionals talked about and understood prioritisations. AIM: The purpose of this study is to explore how healthcare professionals in mental healthcare and somatic medicine prioritise their care, to compare different ways of setting priorities among managers and clinicians and to explore how moral dilemmas are balanced and reconciled...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/28132969/health-related-behaviors-associated-with-subjective-sleep-insufficiency-in-japanese-workers-a-cross-sectional-study
#12
Makoto Kageyama, Keiichi Odagiri, Isagi Mizuta, Makoto Yamamoto, Keiko Yamaga, Takako Hirano, Kazue Onoue, Akihiko Uehara
ObjectivesSleep disturbances are related to somatic and mental disorders, industrial accidents, absenteeism, and retirement because of disability. We aimed to identify health-related behaviors associated with subjective sleep insufficiency in Japanese workers.MethodsThis cross-sectional study included 5,297 employees (mean age: 43.6 ± 11.3 years; 4,039 men). Multiple logistic regression analysis was used to identify health-related behaviors associated with subjective sleep insufficiency.ResultsOverall, 28...
January 28, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/28130990/psychiatric-symptoms-quality-of-life-and-hiv-status-among-people-using-opioids-in-saint-petersburg-russia
#13
Alethea Desrosiers, Elena Blokhina, Evgeny Krupitsky, Edwin Zvartau, Richard Schottenfeld, Marek Chawarski
BACKGROUND: The Russian Federation is experiencing a very high rate of HIV infection among people who inject drugs (PWID). However, few studies have explored characteristics of people with co-occurring opioid use disorders and HIV, including psychiatric symptom presentations and how these symptoms might relate to quality of life. The current study therefore explored a.) differences in baseline psychiatric symptoms among HIV+ and HIV- individuals with opioid use disorder seeking naltrexone treatment at two treatment centers in Saint Petersburg, Russia and b...
January 23, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28125618/re-thinking-anxiety-using-inoculation-messages-to-reduce-and-reinterpret-public-speaking-fears
#14
Ben Jackson, Josh Compton, Ashleigh L Thornton, James A Dimmock
Inoculation theory offers a framework for protecting individuals against challenges to an existing attitude, belief, or state. Despite the prevalence and damaging effects of public speaking anxiety, inoculation strategies have yet to be used to help individuals remain calm before and during public speaking. We aimed to test the effectiveness of an inoculation message for reducing the onset of public speaking anxiety, and helping presenters interpret their speech-related anxiety more positively. Participants (Mage = 20...
2017: PloS One
https://www.readbyqxmd.com/read/28123851/the-fate-of-brca1-related-germline-mutations-in-triple-negative-breast-tumors
#15
Vassiliki Kotoula, Florentia Fostira, Kyriaki Papadopoulou, Paraskevi Apostolou, Eleftheria Tsolaki, Georgios Lazaridis, Kyriaki Manoussou, Flora Zagouri, Dimitrios Pectasides, Ioannis Vlachos, Ioannis Tikas, Sotiris Lakis, Irene Konstantopoulou, George Pentheroudakis, Helen Gogas, Pavlos Papakostas, Christos Christodoulou, Dimitrios Bafaloukos, Evangelia Razis, Vasilios Karavasilis, Christina Bamias, Drakoulis Yannoukakos, George Fountzilas
The preservation of pathogenic BRCA1/2 germline mutations in tumor tissues is usually not questioned, while it remains unknown whether these interact with somatic genotypes for patient outcome. Herein we compared germline and tumor genotypes in operable triple-negative breast cancer (TNBC) and evaluated their combined effects on prognosis. We analyzed baseline germline and primary tumor genotype data obtained by Sanger and Next Generation Sequencing in 194 TNBC patients. We also performed multiple tests interrogating the preservation of germline mutations in matched tumors and breast tissue from carriers with available material...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28121470/impact-of-wheatgrass-triticum-aestivum-l-supplementation-on-atherogenic-lipoproteins-and-menopausal-symptoms-in-hyperlipidemic-south-asian-women-a-randomized-controlled-study
#16
Nitya Kumar, Uma Iyer
OBJECTIVE: The purpose of this study was to evaluate the effect of wheatgrass (Triticum aestivum L.) on atherogenic lipoproteins, inflammation, and menopausal symptoms. METHODS: Fifty-nine hyperlipidemic women were randomized into control (n = 30) and intervention groups (n = 29). Intervention group was administered 3.5 g of freeze-dried wheatgrass powder in encapsulated form daily for 10 weeks, while the control group received no intervention. RESULTS: The intervention group experienced a reduction of 5...
January 25, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28113122/differences-in-psychological-and-somatic-symptom-cluster-score-profiles-between-subjects-with-idiopathic-environmental-intolerance-major-depression-and-schizophrenia
#17
Elisabeth M Weiss, Evelin Singewald, Claudia Baldus, Ellen Hofer, Josef Marksteiner, Sarah Nasrouei, Beatrix Ruepp, Hans-Peter Kapfhammer, Werner Fitz, Christoph Mai, Anke Bauer, Ilona Papousek, Peter Holzer
Idiopathic Environmental Intolerance (IEI) has been associated with psychogenic factors and an increased number of comorbid psychiatric disorders such as depression and anxiety disorder. The purpose of the current study was to examine a possible overlap of psychological and somatic symptoms between subjects with IEI and patients with major depression and schizophrenia as well as to specify characteristic differences. The different symptom clusters included symptoms of chemical intolerance, neurotoxicity and psychological distress as well as measurements of mental health such as anxiety, depression, somatoform symptoms, and schizophrenia-specific disturbances in cognitive domains...
January 5, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28105719/allostatic-load-and-biological-anthropology
#18
Ashley N Edes, Douglas E Crews
Multiple stressors affect developing and adult organisms, thereby partly structuring their phenotypes. Determining how stressors influence health, well-being, and longevity in human and nonhuman primate populations are major foci within biological anthropology. Although much effort has been devoted to examining responses to multiple environmental and sociocultural stressors, no holistic metric to measure stress-related physiological dysfunction has been widely applied within biological anthropology. Researchers from disciplines outside anthropology are using allostatic load indices (ALIs) to estimate such dysregulation and examine life-long outcomes of stressor exposures, including morbidity and mortality...
January 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28103856/relationship-between-the-presence-of-baccalaureate-educated-rns-and-quality-of-care-a-cross-sectional-study-in-dutch-long-term-care-facilities
#19
Ramona Backhaus, Erik van Rossum, Hilde Verbeek, Ruud J G Halfens, Frans E S Tan, Elizabeth Capezuti, Jan P H Hamers
BACKGROUND: Recent evidence suggests that an increase in baccalaureate-educated registered nurses (BRNs) leads to better quality of care in hospitals. For geriatric long-term care facilities such as nursing homes, this relationship is less clear. Most studies assessing the relationship between nurse staffing and quality of care in long-term care facilities are US-based, and only a few have focused on the unique contribution of registered nurses. In this study, we focus on BRNs, as they are expected to serve as role models and change agents, while little is known about their unique contribution to quality of care in long-term care facilities...
January 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28093524/age-associated-b-cells-express-a-diverse-repertoire-of-vh-and-v%C3%AE%C2%BA-genes-with-somatic-hypermutation
#20
Lisa M Russell Knode, Martin S Naradikian, Arpita Myles, Jean L Scholz, Yi Hao, Danya Liu, Mandy L Ford, John W Tobias, Michael P Cancro, Patricia J Gearhart
The origin and nature of age-associated B cells (ABCs) in mice are poorly understood. In this article, we show that their emergence required MHC class II and CD40/CD40L interactions. Young donor B cells were adoptively transferred into congenic recipients and allowed to remain for 1 mo in the absence of external Ag. B cells expressing the T-bet transcription factor, a marker for ABCs, were generated after multiple cell divisions from C57BL/6 donors but not from MHC class II- or CD40-deficient donors. Furthermore, old CD154 (CD40L)-deficient mice did not accrue ABCs, confirming that they arise primarily through T-dependent interactions...
January 16, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
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