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https://www.readbyqxmd.com/read/29927990/ptsd-correlates-with-somatization-in-sexually-abused-children-type-of-abuse-moderates-the-effect-of-ptsd-on-somatization
#1
Seung Min Bae, Jae Myeong Kang, Hyoung Yoon Chang, Woori Han, So Hee Lee
PURPOSE: Somatization is a major post-traumatic symptom in sexually abused children. Thus, the present study aimed to determine the relationship between post-traumatic stress disorder (PTSD) symptoms and somatization, and between intelligence and somatization in child sexual abuse victims and to elucidate whether type of abuse had an effect on the relationship between PTSD symptoms and somatization. METHODS: This study evaluated the somatizations (Child Behavioral Checklist/6-18 [CBCL]), PTSD symptoms (Trauma Symptom Checklist for Children [TSCC]), and intelligence levels of 63 sexually abused children...
2018: PloS One
https://www.readbyqxmd.com/read/29923288/social-genomics-of-healthy-and-disordered-internet-gaming
#2
Jeffrey G Snodgrass, H J François Dengah Ii, Michael G Lacy, Robert J Else, Evan R Polzer, Jesusa M G Arevalo, Steven W Cole
OBJECTIVES: To combine social genomics with cultural approaches to expand understandings of the somatic health dynamics of online gaming, including in the controversial nosological construct of internet gaming disorder (IGD). METHODS: In blood samples from 56 U.S. gamers, we examined expression of the conserved transcriptional response to adversity (CTRA), a leukocyte gene expression profile activated by chronic stress. We compared positively engaged and problem gamers, as identified by an ethnographically developed measure, the Positive and Negative Gaming Experiences Scale (PNGE-42), and also by a clinically derived IGD scale (IGDS-SF9)...
June 20, 2018: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/29920687/chromatin-based-mechanisms-of-temperature-memory-in-plants
#3
Thomas Friedrich, Léa Faivre, Isabel Bäurle, Daniel Schubert
For successful growth and development, plants constantly have to gauge their environment. While plants are capable to monitor their current environmental conditions, they are also able to integrate environmental conditions over time and store the information induced by the cues. In a developmental context, such an environmental memory is used to align developmental transitions with favorable environmental conditions. One temperature-related example of this is the transition to flowering after experiencing winter conditions, i...
June 19, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29909492/modelling-glioma-invasion-using-3d-bioprinting-and-scaffold-free-3d-culture
#4
Derek M van Pel, Kaori Harada, Dandan Song, Christian C Naus, Wun Chey Sin
Glioma is a highly aggressive form of brain cancer, with some subtypes having 5-year survival rates of less than 5%. Tumour cell invasion into the surrounding parenchyma seems to be the primary driver of these poor outcomes, as most gliomas recur within 2 cm of the original surgically-resected tumour. Many current approaches to the development of anticancer therapy attempt to target genetic weaknesses in a particular cancer, but may not take into account the microenvironment experienced by a tumour and the patient-specific genetic differences in susceptibility to treatment...
June 16, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29903880/real-time-genomic-characterization-of-advanced-pancreatic-cancer-to-enable-precision-medicine
#5
Andrew J Aguirre, Jonathan A Nowak, Nicholas D Camarda, Richard A Moffitt, Arezou A Ghazani, Mehlika Hazar-Rethinam, Srivatsan Raghavan, Jaegil Kim, Lauren K Brais, Dorisanne Ragon, Marisa W Welch, Emma Reilly, Devin McCabe, Lori Marini, Kristin Anderka, Karla Helvie, Nelly Oliver, Ana Babic, Annacarolina Da Silva, Brandon Nadres, Emily E Van Seventer, Heather A Shahzade, Joseph P St Pierre, Kelly P Burke, Thomas E Clancy, James M Cleary, Leona A Doyle, Kunal Jajoo, Nadine J McCleary, Jeffrey A Meyerhardt, Janet E Murphy, Kimmie Ng, Anuj K Patel, Kimberly Perez, Michael H Rosenthal, Douglas A Rubinson, Marvin Ryou, Geoffrey I Shapiro, Ewa Sicinska, Stuart G Silverman, Rebecca J Nagy, Richard B Lanman, Deborah Knoerzer, Dean J Welsch, Matthew B Yurgelun, Charles S Fuchs, Levi A Garraway, Gad Getz, Jason L Hornick, Bruce E Johnson, Matthew H Kulke, Robert J Mayer, Jeffrey W Miller, Paul B Shyn, David A Tuveson, Nikhil Wagle, Jen Jen Yeh, William C Hahn, Ryan B Corcoran, Scott L Carter, Brian M Wolpin
Clinically relevant subtypes exist for pancreatic ductal adenocarcinoma (PDAC), but molecular characterization is not yet standard in clinical care. We implemented a biopsy protocol to perform time-sensitive whole exome sequencing and RNA-sequencing for patients with advanced PDAC. Therapeutically relevant genomic alterations were identified in 48% (34/71) and pathogenic/likely pathogenic germline alterations in 18% (13/71) of patients. Overall, 30% (21/71) of enrolled patients experienced a change in clinical management as a result of genomic data...
June 14, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29902052/-loneliness-predicts-self-reported-cold-symptoms-after-a-viral-challenge-correction-to-leroy-et-al-2017
#6
(no author information available yet)
Reports an error in "Loneliness predicts self-reported cold symptoms after a viral challenge" by Angie S. LeRoy, Kyle W. Murdock, Lisa M. Jaremka, Asad Loya and Christopher P. Fagundes ( Health Psychology , 2017[May], Vol 36[5], 512-520). The erratum reports the following acknowledgments that were partially omitted from the author note: Data used in this article were collected by the Laboratory for the Study of Stress, Immunity, and Disease. The data were accessed via the Common Cold Project website...
July 2018: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/29892689/tumor-molecular-profiling-of-responders-and-non-responders-following-pembrolizumab-monotherapy-in-chemotherapy-resistant-advanced-cervical-cancer
#7
N Y L Ngoi, V Heong, X W Lee, Y Q Huang, Y L Thian, B A Choo, D Lim, Y W Lim, S E Lim, A Ilancheran, R Soong, D S P Tan
Optimal treatment for advanced cervical cancer after first line chemotherapy remains undefined. Immune checkpoint inhibition with pembrolizumab, a programmed cell death protein 1(PD-1) inhibitor, is under investigation. We analyzed the micro-environmental and molecular genetic profile of tumors from 4 patients with metastatic cervical cancer treated with off-label second-line pembrolizumab in an effort to identify predictive biomarkers. All patients received 2 mg/kg of pembrolizumab, 3-weekly until disease progression...
May 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29876581/who-is-seeking-whom-a-person-centred-approach-to-help-seeking-in-adults-with-currently-untreated-mental-health-problems-via-latent-class-analysis
#8
S Tomczyk, G Schomerus, S Stolzenburg, H Muehlan, S Schmidt
PURPOSE: Global surveys point to a gap in mental health service utilisation. However, contacting more than one source of professional help may influence the estimates of utilisation. Currently, few studies statistically differentiate between different sources of help based on patient characteristics. METHODS: We assessed sociodemographic and psychosocial data in a convenience sample of 188 adults with mental health problems (Mage  = 50.34 years; SD = 16.19; 71% female), who reported their help-seeking behaviour during the next 6 months...
June 6, 2018: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29867612/sexual-hallucinations-in-schizophrenia-spectrum-disorders-and-their-relation-with-childhood-trauma
#9
Jan Dirk Blom, Esmeralda Mangoenkarso
Background: Sexual hallucinations are probably the most neglected types of hallucination, even in psychiatric settings. They are often multimodal in nature, and their prevalence rate is unknown. For other types of hallucination, notably auditory hallucinations, childhood trauma is an important risk factor. However, whether this also applies to sexual hallucinations is unexplored. Objective: To establish the prevalence rate of sexual hallucinations in a clinical sample of patients diagnosed with a schizophrenia spectrum disorder, to describe their phenomenological characteristics, and to estimate their relationship with childhood trauma...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29865219/development-and-validation-of-a-nausea-severity-scale-for-assessment-of-nausea-in-children-with-abdominal-pain-related-functional-gastrointestinal-disorders
#10
Alexandra C Russell, Amanda L Stone, Andi Wang, Lynn S Walker
The objective of this study was to develop a pediatric measure of chronic nausea severity, the Nausea Severity Scale (NSS), and evaluate its reliability and validity in youth with abdominal pain-related functional gastrointestinal disorders (AP-FGID). Pediatric patients (aged 11⁻17 years-old, n = 236) presenting to an outpatient clinic for evaluation of abdominal pain completed the NSS, Children's Somatization Inventory (CSI), Functional Disability Inventory (FDI), Abdominal Pain Index (API), Patient-Report Outcomes Measurement Information System (PROMIS), Anxiety and Depression Scales and the Pediatric Rome III Questionnaire for FGIDs...
June 1, 2018: Children
https://www.readbyqxmd.com/read/29863389/-initiation-and-retention-in-couples-outpatient-treatment-for-parents-with-drug-and-alcohol-use-disorders-correction
#11
(no author information available yet)
Reports an error in "Initiation and retention in couples outpatient treatment for parents with drug and alcohol use disorders" by Abby L. Braitman and Michelle L. Kelley ( Experimental and Clinical Psychopharmacology , 2016[Jun], Vol 24[3], 174-184). In the article, there are errors in Table 2. In the corrected table, the impact of Men's perpetration of violence changes from a non-significant trend (p < .10) to a significant effect (p < .05). Also within Table 2, Women's dyadic cohesion effect changed from a significant finding to a non-significant trend (p ...
June 2018: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29859342/maternal-distress-and-hair-cortisol-in-pregnancy-among-women-with-elevated-adverse-childhood-experiences
#12
Katherine Bowers, Lili Ding, Samantha Gregory, Kimberly Yolton, Hong Ji, Jerrold Meyer, Robert T Ammerman, Judith Van Ginkel, Alonzo Folger
Life-course exposure to stress is associated with a wide-range of health outcomes. Early childhood adversity may affect an individual's future response to stress. This is of particular concern during pregnancy as early maternal stress may impact the stress response in pregnancy, altering fetal exposure. We therefore hypothesized maternal childhood adversity may interact with distress experienced in pregnancy affecting maternal cortisol accumulation in pregnancy. Analyses were conducted within the PRegnancy and Infant Development (PRIDE) Study, a cohort of mother-infant pairs participating in Every Child Succeeds, a home visiting program in Cincinnati, Ohio...
May 18, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29794310/superior-outcomes-following-cervical-fusion-vs-multimodal-rehabilitation-in-a-subgroup-of-randomized-whiplash-associated-disorders-wad-patients-indicating-somatic-pain-origin-comparison-of-outcome-assessments-made-by-four-examiners-from-different-disciplines
#13
Elisabeth Svensson, Bo Nyström, Ian Goldie, Nils Inge Landrø, Åke Sidén, Peer Staff, Birgitta Schillberg, Adam Taube
BACKGROUND AND AIMS: Whiplash-Associated Disorders (WAD) are characterized by great variability in long-term symptoms. Patients with central neck and movement-induced stabbing pain participated in a randomized study comparing cervical fusion and multimodal rehabilitation. As reported in our previous paper, more patients treated by cervical fusion than by rehabilitation experienced pain relief. Although patient reported outcome measures are a core component of outcome evaluation, independent examiner has been recommended...
April 25, 2018: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29781924/changes-in-psychiatric-and-medical-conditions-and-health-care-utilization-following-a-diagnosis-of-sexual-assault-a-retrospective-cohort-study
#14
Kelly C Young-Wolff, Varada Sarovar, Daniella Klebaner, Felicia Chi, Brigid McCaw
INTRODUCTION: Sexual assault (SA) is alarmingly common and is associated with higher prevalence of psychiatric and medical conditions. However, many prior studies are limited to cross-sectional designs. Health care systems with electronic health records provide unique longitudinal data to examine whether SA is associated with changes in health and health care utilization. METHODS: The sample included 1350 Kaiser Permanente Northern California adult female patients with a SA diagnosis from 2009 to 2015 and 4050 adult female patients without a SA diagnosis, matched on age, medical facility, and continuous enrollment during the study period...
May 17, 2018: Medical Care
https://www.readbyqxmd.com/read/29756084/reconsidering-the-international-association-for-the-study-of-pain-definition-of-pain
#15
REVIEW
Milton Cohen, John Quintner, Simon van Rysewyk
Introduction: The definition of pain promulgated by the International Association for the Study of Pain (IASP) is widely accepted as a pragmatic characterisation of that human experience. Although the Notes that accompany it characterise pain as "always subjective," the IASP definition itself fails to sufficiently integrate phenomenological aspects of pain. Methods: This essay reviews the historical development of the IASP definition, and the commentaries and suggested modifications to it over almost 40 years...
March 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29748345/parents-experience-when-their-child-has-chronic-abdominal-pain-a-qualitative-study-in-norway
#16
Anne Brodwall, Kari Glavin, Per Lagerløv
OBJECTIVE: Functional abdominal pain occurs frequently in children and adolescents. It is an exclusion diagnosis; somatic diseases have to be ruled out. However little explanation is given for why the child is experiencing pain. The aim was to explore the experiences of parents of children with chronic abdominal pain discharged from hospital without a somatic explanation. DESIGN: The study has a qualitative design. The open questions concerned pain experiences and management...
May 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29746855/the-first-multi-zoo-application-of-an-allostatic-load-index-to-western-lowland-gorillas-gorilla-gorilla-gorilla
#17
Ashley N Edes, Barbara A Wolfe, Douglas E Crews
Vertebrate stress responses are highly adaptive biological functions, maximizing survival probability in life-threatening situations. However, experiencing repeated and/or chronic stressors can generate physiological dysregulation and lead to disease. Because stress responses are multi-systemic and involve a wide range of physiological functions, identifying responses to stressors is best accomplished using integrated biomarker models. Allostatic load, defined as the physiological dysregulation that accumulates over the lifespan due to stressful experiences, is one such model...
May 7, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29745889/potentially-traumatic-events-ptsd-and-post-traumatic-stress-spectrum-in-patients-with-fibromyalgia
#18
Ciro Conversano, Claudia Carmassi, Carlo A Bertelloni, Laura Marchi, Tommaso Micheloni, Manuel G Carbone, Giovanni Pagni, Claudia Tagliarini, Gabriele Massimetti, Laura M Bazzichi, Liliana Dell'Osso
OBJECTIVES: Fibromyalgia (FM) is defined as a severe, chronic, non-articular rheumatic condition characterised by widespread musculoskeletal pain, hyperalgesia and generalised tender points, in the absence of inflammatory or structural musculoskeletal abnormalities. Pain is the predominant symptom, allodynia and hyperalgesia are common signs. Extreme fatigue, impaired cognition and non-restorative sleeping difficulties coexist in addition to other somatic symptoms. Several studies suggest there is a meaningful relationship between FM and the psychological symptoms of depression and post-traumatic stress disorder (PTSD)...
April 24, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29741795/characteristics-of-perceived-electromagnetic-hypersensitivity-in-the-general-population
#19
Michael J Gruber, Eva Palmquist, Steven Nordin
Health problems evoked in the presence of electrical equipment is a concern, calling for better understanding for characteristics of electromagnetic hypersensitivity (EHS) in the general population. The present study investigated demographics, lifestyle factors, frequency and duration, coping strategies, proportion meeting clinical criteria for intolerance attributed to electromagnetic fields (EMF) and comorbidity. Using data from a large-scale population-based questionnaire study, we investigated persons with self-reported (n = 91) EHS in comparison to referents (n = 3,250)...
May 9, 2018: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/29701882/an-empirical-test-for-a-zone-of-canalization-in-thermal-reaction-norms
#20
Erlend I F Fossen, Christophe Pélabon, Sigurd Einum
Theoretical models on the evolution of phenotypic plasticity predict a zone of canalization where reaction norms cross, and genetic variation is minimized in the environment a population most frequently encounter. Empirical tests of this prediction are largely missing, in particular for life-history traits. We addressed this prediction by quantifying thermal reaction norms of three life-history traits (somatic growth rate, age and size at maturation) of a Norwegian population of Daphnia magna and testing for the occurrence of an intermediate temperature (Tm ) at which genetic variance in the traits is minimized...
April 27, 2018: Journal of Evolutionary Biology
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