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https://www.readbyqxmd.com/read/28654954/bioequivalence-between-generic-and-branded-lamotrigine-in-people-with-epilepsy-the-equigen-randomized-clinical-trial
#1
Michel Berg, Timothy E Welty, Barry E Gidal, Francisco J Diaz, Ron Krebill, Jerzy P Szaflarski, Barbara A Dworetzky, John R Pollard, Edmund J Elder, Wenlei Jiang, Xiaohui Jiang, Regina D Switzer, Michael D Privitera
Importance: Switching between generic antiepileptic drugs is a highly debated issue that affects both clinical care and overall health care costs. Objective: To evaluate the single-dose pharmacokinetic bioequivalence of 3 (1 branded and 2 generic drugs) on-market, immediate-release lamotrigine drug products. Design, Setting, and Participants: The Equivalence Among Antiepileptic Drug Generic and Brand Products in People With Epilepsy (EQUIGEN) single-dose study is a crossover, prospective, sequence-randomized, replicate pharmacokinetic study conducted at 5 US academic epilepsy centers...
June 26, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28654822/gender-and-the-structure-of-self-rated-health-across-the-adult-life-span
#2
Anna Zajacova, Snehalata Huzurbazar, Megan Todd
Despite the widespread use of self-rated health (SRH) in population health studies, the meaning of this holistic health judgment remains an open question. Gender differences in health, an issue of utmost importance in population research and policy, are often measured with SRH; the comparisons could be biased if men and women differ in how they form their health judgment. The aim of this study is to examine whether men and women differ in how health inputs predict their health rating across the adult life span...
June 16, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28653739/clinical-significance-of-fascin-1-and-laminin-5-in-non-small-cell-lung-cancer
#3
L Yang, Y Teng, T-P Han, F-G Li, W-T Yue, Z-T Wang
Lung cancer is the leading cause of cancer death in men and the second leading cause of cancer death in women worldwide. Fascin-1 and laminin-5 were associated with the invasiveness and prognoses of several cancers. The expression and the serum levels of fascin-1 and laminin-5 in patients with non-small cell lung cancer (NSCLC) were analyzed in this study. The expression of fascin-1 and laminin-5 were examined in 378 patients and their serum level was measured in 154 patients. The health of all patients was followed post-surgery...
June 20, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28653566/educational-inequalities-in-hospital-care-for-mortally-ill-patients-in-norway
#4
Jon Ivar Elstad
AIMS: Health care should be allocated fairly, irrespective of patients' social standing. Previous research suggests that highly educated patients are prioritized in Norwegian hospitals. This study examines this contentious issue by a design which addresses two methodological challenges. Control for differences in medical needs is approximated by analysing patients who died from same causes of death. Area fixed effects are used for avoiding that observed educational inequalities are contaminated by geographical differences...
June 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28653499/exercise-s-effect-on-mobility-disability-in-older-adults-with-and-without-obesity-the-life-study-randomized-clinical-trial
#5
Stephen B Kritchevsky, Laura Lovato, Elizabeth P Handing, Steven Blair, Anda Botoseneanu, Jack M Guralnik, Christine Liu, Abby King, Anthony P Marsh, Marco Pahor, W Jack Rejeski, Bonnie Spring, Todd Manini
OBJECTIVE: Some data suggest that obesity blunts the benefits of exercise on mobility in older adults. This study tested the homogeneity of the effect of a physical activity intervention on major mobility disability (MMD) across baseline obesity classifications in the Lifestyle Interventions and Independence for Elders (LIFE) Study. LIFE randomized 1,635 sedentary men and women aged 70 to 89 years to a moderate-intensity physical activity (PA) or health education program. METHODS: MMD, defined as the inability to walk 400 m, was determined over an average follow-up of 2...
July 2017: Obesity
https://www.readbyqxmd.com/read/28653265/what-s-religion-got-to-do-with-it-exploring-college-students-sexual-and-reproductive-health-knowledge-and-awareness-of-sexual-and-reproductive-health-services-in-relation-to-their-gender-and-religiosity
#6
Nancy Martin, Lori Baralt, Claire Garrido-Ortega
The purpose of this study was to examine the relationship between religiosity and sexual and reproductive health (SRH) knowledge and awareness of campus SRH services among college students on a racially and ethnically diverse college campus. The sample included 996 undergraduate students at a large public university in California. For women, there was a consistent pattern across religious affiliations of more frequent attenders reporting lower SRH knowledge than less frequent attenders. These findings suggest that higher rates of religious attendance among Catholic, Protestant, and Evangelical women pose a risk for lower SRH knowledge...
June 26, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28653107/a-multicenter-study-of-attitudinal-barriers-to-cancer-pain-management
#7
Sigridur Gunnarsdottir, Valgerdur Sigurdardottir, Marianne Kloke, Lukas Radbruch, Rainer Sabatowski, Stein Kaasa, Pål Klepstad
PURPOSE: The purpose of this study was to examine attitudinal barriers to cancer pain management and their relationship to pain, analgesic use, clinical, and demographic variables, as well as QOL, in a large sample of patients receiving strong opioids for pain in three European countries. METHODS: Participants in the present study were 555 patients with cancer, 18 years and older recruited from six centers in Germany, Iceland, and Norway. All had received strong opioids for at least 72 h...
June 26, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28652821/hiv-risk-and-barriers-to-care-for-african-born-immigrant-women-a-sociocultural-outlook
#8
Olihe N Okoro, Shanasha O Whitson
BACKGROUND: Data from the Minnesota Department of Health (MDH) HIV/AIDS Surveillance Report 2015 show that African-born (AB) women continue to be disproportionately affected by HIV. In 2015, these women accounted for more than half (54%) of all new cases of HIV reported among females in Minnesota and 34% of all known female cases in the state. This study was a needs assessment for HIV pre-exposure prophylaxis (PrEP) in vulnerable subgroups within the AB population and adequacy of HIV care for AB persons...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28652180/serum-levels-of-dickkopf-1-are-a-potential-negative-biomarker-of-survival-in-geriatric-patients
#9
Peter Dovjak, Georg Heinze, Anna Rainer, Wolfgang Sipos, Peter Pietschmann
Fragility fractures due to osteoporosis and its most dreaded complication - hip fractures - are the cause of disability, high mortality and place a considerable burden on global health economics. Although much work has been done to accurately predict mortality and find risk factors for poor health outcome, little attention was given to the Wnt-catenin signaling pathway and its role in the posttraumatic course of disease. We studied 238 geriatric patients (175 women (mean age 84yrs) and 63 men (mean age 82yrs)) in total that were admitted to a department of Acute Geriatric Care...
June 23, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28651843/-neisseria%C3%A2-meningitidis-urethritis-two-case-reports
#10
C Dubois, A-L Liegeon, C Fabbro, F Truchetet
BACKGROUND: Neisseria meningitidis (NM) is a commensal bacteria present in the oropharyngeal flora that causes invasive infections. There have been rarer reports of presence in the genital region. Herein, we present two cases of acute NM urethritis. PATIENTS AND METHODS: Two men aged 30 and 31years, one of whom is homosexual and seropositive for HIV infection, presented urethral discharge which was diagnosed as acute urethritis. The unit through samples indicated the presence of NM of serogroups B and C...
June 23, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28651827/effects-of-nutrition-and-physical-exercise-intervention-in-palliative-cancer-patients-a-randomized-controlled-trial
#11
Alexandra Uster, Maya Ruehlin, Stefanie Mey, David Gisi, Ruud Knols, Reinhard Imoberdorf, Miklos Pless, Peter E Ballmer
BACKGROUND & AIMS: Cancer cachexia is multifactorial and should be targeted using a multimodal form of intervention. The purpose of the present trial was to test the effects of a combined nutrition and physical exercise program on cancer patients with metastatic or locally advanced tumors of the gastrointestinal and lung tracts. METHODS: Patients were randomized into two groups: One group received a minimum of three standardized individual nutritional counselling sessions and participated in a 60-min exercise program twice a week...
June 8, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28651657/association-between-violent-crime-and-psychosis-in-men-serving-prison-terms
#12
Javier Saavedra, Marcelino López, M Eva Trigo
Psychosis has been associated with committing violent crimes. However, it has been reported that the association is mediated by toxin consumption, personality disorders, and positive symptoms. This study will examine the relationship between different psychological disorders and sociodemographic variables, and violent crime perpetration in a sample of 472 men serving prison terms in Andalusia, Spain. A correlation-based, retrospective study was conducted and data were analyzed through logistic regression. The sample is representative of the Andalusian prison population, with a 95% level of confidence and ...
June 27, 2017: Spanish Journal of Psychology
https://www.readbyqxmd.com/read/28651597/change-in-body-mass-index-during-transition-to-statutory-retirement-an-occupational-cohort-study
#13
Sari Stenholm, Svetlana Solovieva, Eira Viikari-Juntura, Ville Aalto, Mika Kivimäki, Jussi Vahtera
BACKGROUND: Retirement is a major life transition affecting health behaviors. The aim of this study was to examine within-individual changes in body mass index (BMI) during transition from full-time work to statutory retirement by sex and physical work characteristics. METHODS: A multiwave cohort study repeated every 4 years and data linkage to records from retirement registers. Participants were 5426 Finnish public-sector employees who retired on a statutory basis in 2000-2011 and who reported their body weight one to three times prior to (w-3, w-2, w-1), and one to three times after (w+1, w+2, w+3) retirement...
June 26, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28651463/-what-do-family-medicine-trainees-think-about-gratitude-payment
#14
Zsuzsa Győrffy, László Kalabay, András Mohos, Bernadett Márkus, Anna Nánási, József Rinfel, Edmond Girasek, Péter Torzsa
INTRODUCTION: The issue of gratuity is one of the most important health policy issues in Hungary. AIM: The authors' aim is to investigate the attitude of Hungarian family medicine trainees towards gratitude payment. METHOD: Quantitative, paper-based survey among trainees from four Departments of Family Medicine in Hungary (n = 152). RESULTS: More than 50 percent of the residents do not approve of accepting gratitude money...
July 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28651390/-cross-sectional-survey-of-smoking-and-smoking-cessation-behaviors-in-adults-in-jiangxi-province-2013
#15
Y Y Chen, L P Zhu, W Yan, J Liu, L Ji, Y Xu
Objective: To describe the prevalence of smoking and smoking cessation in adults of Jiangxi province in 2013. Methods: Multi-stage stratified cluster random sampling method was used to select 6 000 individuals aged ≥18 years from 10 chronic and non-communicable disease and risk factor surveillance points of Jiangxi province in 2013. A face-to-face questionnaire survey was carried out to collect information about the risk factors for chronic and non-communicable diseases and 5 997 records were used in final analysis of smoking and smoking cessation...
May 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28651372/living-arrangements-disability-and-gender-of-older-adults-among-rural-south-africa
#16
Enid Schatz, Margaret Ralston, Sangeetha Madhavan, Mark A Collinson, F Xavier Gómez-Olivé
Objective: A limited understanding exists of the relationship between disability and older persons' living arrangements in low and middle-income countries (LMICs). We examine the associations between living arrangements, disability, and gender for individuals older than 50 years in rural South Africa. Method: Using the Study on global AGEing and adult health (SAGE) survey and Agincourt Health and socio-Demographic Surveillance System (HDSS) data, we explore older persons' self-reported disability by living arrangements and gender, paying particular attention to various multigenerational arrangements...
June 23, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28651187/association-of-ectopic-fat-with-abdominal-aorto-illiac-and-coronary-artery-calcification-in-african-ancestry-men
#17
Allison L Kuipers, Joseph M Zmuda, J Jeffrey Carr, James G Terry, Sangeeta Nair, Ryan Cvejkus, Clareann H Bunker, Alan L Patrick, Christina L Wassel, Iva Miljkovic
BACKGROUND AND AIMS: There is strong evidence that fat accumulating in non-adipose sites, "ectopic fat", is associated with cardiovascular disease (CVD), including vascular calcification. Most previous studies of this association have assessed only a single ectopic fat depot. Therefore, our aim was to assess the association of total, regional, and ectopic fat with abdominal aorto-illiac calcification (AAC) and coronary artery calcification (CAC) in 798 African ancestry men. METHODS: Participants (mean age 62) were from the Tobago Bone Health Study cohort...
June 16, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28651179/sedentary-work-and-the-risks-of-colon-and-rectal-cancer-by-anatomical-sub-site-in-the-canadian-census-health-and-environment-cohort-canchec
#18
Manisha Pahwa, M Anne Harris, Jill MacLeod, Michael Tjepkema, Paul A Peters, Paul A Demers
BACKGROUND: Sedentary behaviour is a potential risk factor for colorectal cancer. We examined the association between sedentary work, based on body position, and colorectal cancer risk in Canadians. METHODS: A working body position category (a. sitting; b. standing and walking; c. sitting, standing, and walking; d. other) was assigned to occupations reported by 1991 Canadian Census respondents based on national occupational counselling guidelines. Adjusted hazard ratios (HRs) and 95% confidence intervals (CI) were estimated for cancers of the colon (overall, proximal, and distal) and rectum in men and women newly diagnosed from 1992 to 2010...
June 23, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28650380/high-levels-of-post-migration-hiv-acquisition-within-nine-european-countries
#19
Debora Alvarez-Del Arco, Fakoya Ibidun, Christos Thomadakis, Nikos Pantazis, Giota Touloumi, Anne-Francoise Gennotte, Freke Zuure, Henrique Barros, Cornelia Staehelin, Siri Göpel, Christoph Boesecke, Tullio Prestileo, Alain Volny-Anne, Fiona Burns, Julia Del Amo
OBJECTIVE: We aimed to estimate the proportion of post-migration HIV acquisition among HIV-positive migrants in Europe. DESIGN: To reach HIV positive migrants we designed a cross sectional study performed in HIV clinics. METHODS: The study was conducted from July 2013-July 2015 in 57 clinics (9 European countries, targeting individuals over 18 years diagnosed in the preceding 5 years and born abroad. Electronic questionnaires supplemented with clinical data were completed in any of 15 languages...
June 23, 2017: AIDS
https://www.readbyqxmd.com/read/28650253/diagnosis-and-treatment-of-osteoporosis-before-and-after-fracture-a-side-by-side-analysis-of-commercially-insured-and-medicare-advantage-osteoporosis-patients
#20
Jessica Weaver, Shiva Sajjan, E Michael Lewiecki, Steven T Harris
BACKGROUND: Although treatment for osteoporosis is recommended by U.S. clinical guidelines, a lack of diagnosis and treatment is common among patients with osteoporotic fractures. OBJECTIVE: To determine the rates of osteoporosis diagnosis and treatment before and after various types of fractures. METHODS: This was a retrospective claims analysis using data from the Humana Medicare Advantage claims (Medicare group) and Optum Insight Clinformatics Data Mart commercial claims (Commercial group)...
July 2017: Journal of Managed Care & Specialty Pharmacy
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