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Biologic mesh

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https://www.readbyqxmd.com/read/28425679/soft-interactions-and-volume-exclusion-by-polymeric-crowders-can-stabilize-or-destabilize-transient-structure-in-disordered-proteins-depending-on-polymer-concentration
#1
Farai I Rusinga, David D Weis
The effects of macromolecular crowding on the transient structure of intrinsically disordered proteins is not well-understood. Crowding by biological molecules inside cells could modulate transient structure and alter IDP function. Volume exclusion theory and observations of structured proteins suggest that IDP transient structure would be stabilized by macromolecular crowding. Amide hydrogen exchange (HX) of IDPs in highly concentrated polymer solutions would provide valuable insights into IDP transient structure under crowded conditions...
April 20, 2017: Proteins
https://www.readbyqxmd.com/read/28419245/support-of-the-aortic-wall-a-histological-study-in-sheep-comparing-a-macroporous-mesh-with-low-porosity-vascular-graft-of-the-same-polyethylene-terephthalate-material
#2
Lucas Van Hoof, Peter Verbrugghe, Erik Verbeken, Tom Treasure, Nele Famaey, Bart Meuris, Paul Herijgers, Filip Rega
OBJECTIVES: Wrapping with various materials was an early treatment for aortic aneurysms. Wrapping with low-porosity vascular grafts has been associated with graft migration and vascular erosion. An alternative is to use a macroporous mesh (MPM) made of the same polymer (polyethylene terephalate). We compared the histological outcome 1 year after wrapping sheep aortas with low-porosity grafts versus MPM fabrics. METHODS: The 2 different fabrics were wrapped around the aorta of 3 sheep...
April 16, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28417997/iterative-expansion-microscopy
#3
Jae-Byum Chang, Fei Chen, Young-Gyu Yoon, Erica E Jung, Hazen Babcock, Jeong Seuk Kang, Shoh Asano, Ho-Jun Suk, Nikita Pak, Paul W Tillberg, Asmamaw T Wassie, Dawen Cai, Edward S Boyden
We recently developed a method called expansion microscopy, in which preserved biological specimens are physically magnified by embedding them in a densely crosslinked polyelectrolyte gel, anchoring key labels or biomolecules to the gel, mechanically homogenizing the specimen, and then swelling the gel-specimen composite by ∼4.5××Iterative expansion microscopyJae-Byum Chang1,2, Fei Chen3, Young-Gyu Yoon1,4, Erica E Jung1, Hazen Babcock5, Jeong Seuk Kang6, Shoh Asano1, Ho-Jun Suk7, Nikita Pak8, Paul W Tillberg4, Asmamaw T Wassie3, Dawen Cai9 &Edward S Boyden1,3,10,11We recently developed a method called expansion microscopy, in which preserved biological specimens are physically magnified by embedding them in a densely crosslinked polyelectrolyte gel, anchoring key labels or biomolecules to the gel, mechanically homogenizing the specimen, and then swelling the gel-specimen composite by ~4...
April 17, 2017: Nature Methods
https://www.readbyqxmd.com/read/28413333/equilibrium-shapes-of-a-heterogeneous-bubble-in-an-electric-field-a-variational-formulation-and-numerical-verifications
#4
Hanxiong Wang, Liping Liu, Dong Liu
The equilibrium shape of a bubble/droplet in an electric field is important for electrowetting over dielectrics (EWOD), electrohydrodynamic (EHD) enhancement for heat transfer and electro-deformation of a single biological cell among others. In this work, we develop a general variational formulation in account of electro-mechanical couplings. In the context of EHD, we identify the free energy functional and the associated energy minimization problem that determines the equilibrium shape of a bubble in an electric field...
March 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28412712/antitumor-necrosis-factor-%C3%AE-therapy-associated-with-inflammatory-bowel-disease-three-cases-and-a-systematic-literature-review
#5
Amir Bieber, Abdallah Fawaz, Irena Novofastovski, Reuven Mader
OBJECTIVE: Antitumor necrosis factor-α (anti-TNF-α) therapy is the most prescribed biologic agent therapy in rheumatology and gastroenterology. However, a number of serious side effects have been reported with these drugs. Only a handful of cases of new-onset inflammatory bowel disease (IBD), mostly in children diagnosed with juvenile idiopathic arthritis (JIA), have been reported during anti-TNF-α therapy. We present 3 cases of adult IBD following anti-TNF-α therapy and a literature review on this topic...
April 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28400698/laparoscopic-rectopexy-with-urinary-bladder-xenograft-reinforcement
#6
Aradhana Mehta, Rami Afshar, David L Warner, Amy Gardner, Ellen Ackerman, Jared Brandt, Kent C Sasse
BACKGROUND AND OBJECTIVES: Rectal prolapse is often repaired laparoscopically, frequently with the use of reinforcement material. Both synthetic and biologically derived materials reduce recurrence rate compared to primary suture repair. Synthetic mesh introduces potential complications such as mesh erosion, fibrosis, and infection. Urinary bladder matrix (UBM) represents a biologically derived material for reinforcement of rectal prolapse repair with the potential to improve durability without risks of synthetic materials...
January 2017: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/28384341/discrete-multi-physics-a-mesh-free-model-of-blood-flow-in-flexible-biological-valve-including-solid-aggregate-formation
#7
Mostapha Ariane, Mohamed Hatem Allouche, Marco Bussone, Fausto Giacosa, Frédéric Bernard, Mostafa Barigou, Alessio Alexiadis
We propose a mesh-free and discrete (particle-based) multi-physics approach for modelling the hydrodynamics in flexible biological valves. In the first part of this study, the method is successfully validated against both traditional modelling techniques and experimental data. In the second part, it is further developed to account for the formation of solid aggregates in the flow and at the membrane surface. Simulations of various types of aggregates highlight the main benefits of discrete multi-physics and indicate the potential of this approach for coupling the hydrodynamics with phenomena such as clotting and calcification in biological valves...
2017: PloS One
https://www.readbyqxmd.com/read/28374739/mechano-regulated-surface-for-manipulating-liquid-droplets
#8
Xin Tang, Pingan Zhu, Ye Tian, Xuechang Zhou, Tiantian Kong, Liqiu Wang
The effective transfer of tiny liquid droplets is vital for a number of processes such as chemical and biological microassays. Inspired by the tarsi of meniscus-climbing insects, which can climb menisci by deforming the water/air interface, we developed a mechano-regulated surface consisting of a background mesh and a movable microfibre array with contrastive wettability. The adhesion of this mechano-regulated surface to liquid droplets can be reversibly switched through mechanical reconfiguration of the microfibre array...
April 4, 2017: Nature Communications
https://www.readbyqxmd.com/read/28373083/3d-screening-device-for-the-evaluation-of-cell-response-to-different-electrospun-microtopographies
#9
G Criscenti, A Vasilevich, A Longoni, C De Maria, C A van Blitterswijk, R Truckenmuller, G Vozzi, J De Boer, L Moroni
Micro- and nano-topographies of scaffold surfaces play a pivotal role in tissue engineering applications, influencing cell behavior such as adhesion, orientation, alignment, morphology and proliferation. In this study, a novel microfabrication method based on the combination of soft-lithography and electrospinning for the production of micro-patterned electrospun scaffolds was proposed. Subsequently, a 3D screening device for electrospun meshes with different micro-topographies was designed, fabricated and biologically validated...
March 31, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28372449/enteral-stent-for-the-treatment-of-a-urinary-fistula-associated-with-a-biological-mesh-following-a-bricker-type-procedure
#10
Raquel Díaz Ruiz, Marta Castillo Pradillo, Óscar Nogales Rincón, Cecilia González Asanza
Postoperative fistula results in increased morbidity and a longer hospital stay. While surgery is the most common treatment, the endoscopic approach is an increasingly used alternative. A 57-year-old woman underwent surgery for colonic adenocarcinoma, which relapsed as peritoneal carcinomatosis and was managed with chemotherapy and surgery, a biological Permacol™ mesh was used for abdominal wall closure.
April 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28371010/laparoscopic-ventral-rectopexy-for-rectal-prolapse-and-rectal-intussusception-using-a-biological-mesh
#11
Sinan Albayati, Matthew J Morgan, Catherine E Turner
AIM: Laparoscopic ventral rectopexy (LVR) is a nerve sparing technique for the treatment of rectal prolapse. Concerns about the use of synthetic meshes in the pelvis and the associated risk of erosion have led to the recent use of biological meshes in some colorectal units. This retrospective study aims to assess the outcomes of patients undergoing LVR using a non-cross-linked non-dermal biological mesh. METHODS: Medical notes of all patients who underwent LVR between December 2011 and May 2014 were reviewed...
March 29, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28358639/review-of-hazards-to-female-reproductive-health-in-veterinary-practice
#12
Joni M Scheftel, Brigid L Elchos, Carol S Rubin, John A Decker
OBJECTIVE To review publications that address female reproductive health hazards in veterinary practice, summarize best practices to mitigate reproductive risks, and identify current knowledge gaps. DESIGN Systematized review. SAMPLE English-language articles describing chemical, biological, and physical hazards present in the veterinary workplace and associations with adverse reproductive outcomes or recommendations for minimizing risks to female reproductive health. PROCEDURES Searches of the CAB abstracts database were performed in July 2012 and in May 2015 with the following search terms: veterinarians AND occupational hazards and vets...
April 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28349130/design-strategies-and-applications-of-biomaterials-and-devices-for-hernia-repair
#13
Surge Kalaba, Ethan Gerhard, Joshua S Winder, Eric M Pauli, Randy S Haluck, Jian Yang
Hernia repair is one of the most commonly performed surgical procedures worldwide, with a multi-billion dollar global market. Implant design remains a critical challenge for the successful repair and prevention of recurrent hernias, and despite significant progress, there is no ideal mesh for every surgery. This review summarizes the evolution of prostheses design toward successful hernia repair beginning with a description of the anatomy of the disease and the classifications of hernias. Next, the major milestones in implant design are discussed...
September 2016: Bioactive Materials
https://www.readbyqxmd.com/read/28335186/ex-vivo-tissues-engineering-modeling-for-reconstructive-surgery-using-human-adult-adipose-stem-cells-and-polymeric-nanostructured-matrix
#14
Francesco Morena, Chiara Argentati, Eleonora Calzoni, Marino Cordellini, Carla Emiliani, Francesco D'Angelo, Sabata Martino
The major challenge for stem cell translation regenerative medicine is the regeneration of damaged tissues by creating biological substitutes capable of recapitulating the missing function in the recipient host. Therefore, the current paradigm of tissue engineering strategies is the combination of a selected stem cell type, based on their capability to differentiate toward committed cell lineages, and a biomaterial, that, due to own characteristics (e.g., chemical, electric, mechanical property, nano-topography, and nanostructured molecular components), could serve as active scaffold to generate a bio-hybrid tissue/organ...
March 31, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28331265/delayed-closure-of-61-open-abdomen-patients-based-on-an-algorithm
#15
Fahri Yetisir, A Ebru Sarer, Hasan Zafer Acar, Muhittin Aygar
Hemodynamic resuscitation, source control, and delayed abdominal closure are the three fundamental steps for open abdomen (OA) management. When to start delayed abdominal closure and how to determine which delayed closure method should be applied to each OA patient are not clarified in the literature. We evaluated an algorithm that was developed to address these two questions. A retrospective chart review was conducted for OA patients treated for according to the algorithm. When hemodynamic stabilization and source control using negative pressure therapy resulted in regression of sepsis and decreased procalcitonin levels, patients were assigned to either the skin-only or fascial closure groups according to their Björck scores and open abdominal fascial closure (OAFC) scores...
February 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28323397/in-vivo-response-to-decellularized-mesothelium-scaffolds
#16
Michael J Cronce, Renea A Faulknor, Irina Pomerantseva, Xiang-Hong Liu, Scott M Goldman, Emmanuel C Ekwueme, Olive Mwizerwa, Craig M Neville, Cathryn A Sundback
Biological surgical scaffolds are used in plastic and reconstructive surgery to support structural reinforcement and regeneration of soft tissue defects. Macrophage and fibroblast cell populations heavily regulate scaffold integration into host tissue following implantation. In the present study, the biological host response to a commercially available surgical scaffold (Meso BioMatrix Surgical Mesh (MBM)) was investigated for up to 9 weeks after subcutaneous implantation; this scaffold promoted superior cell migration and infiltration previously in in vitro studies relative to other commercially available scaffolds...
March 21, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28318504/-economic-evaluation-of-medical-devices-not-included-in-the-french-list-of-products-and-services-qualifying-for-reimbursement-example-of-biologic-meshes
#17
A Sainfort, I Denis-Hallouard, G Aulagner, O Nuiry, X Armoiry
OBJECTIVES: To present a method aimed to evaluate the economic impact associated with the use of medical devices (DM) not reimbursed in addition to diagnosis related groups (DRGs) tariffs using the example of biological meshes for parietal reinforcement. METHODS: In this multicenter retrospective cohort study, we included all patients who received a biological mesh between January 2010-April 2014 (University hospitals of Saint-Étienne, France) or between January 2010-March 2015 (Lyon University hospitals, France)...
March 16, 2017: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/28299927/supramolecular-hydrogels-based-on-dna-self-assembly
#18
Yu Shao, Haoyang Jia, Tianyang Cao, Dongsheng Liu
Extracellular matrix (ECM) provides essential supports three dimensionally to the cells in living organs, including mechanical support and signal, nutrition, oxygen, and waste transportation. Thus, using hydrogels to mimic its function has attracted much attention in recent years, especially in tissue engineering, cell biology, and drug screening. However, a hydrogel system that can merit all parameters of the natural ECM is still a challenge. In the past decade, deoxyribonucleic acid (DNA) has arisen as an outstanding building material for the hydrogels, as it has unique properties compared to most synthetic or natural polymers, such as sequence designability, precise recognition, structural rigidity, and minimal toxicity...
March 16, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28299156/fifty-shades-of-african-lightness-a-bio-psychosocial-review-of-the-global-phenomenon-of-skin-lightening-practices
#19
REVIEW
Meagan Jacobs, Susan Levine, Kate Abney, Lester Davids
Skin-lightening is an aesthetic practice of global concern. By adopting a biopsycho-social approach, we consider the interplay between the biological, psychological and social factors that underpin the circulation and consumption of skin lighteners in South Africa. This paper reflects on biological aspects of skin lightening, interpersonal relationships, individual beliefs and expectations about the maintenance of health and well being that informs cosmetic practices. The paper seeks to examine claims made by historians (Thomas) and political philosophers and activists (Biko) that colonialism and apartheid in South Africa historically reinforced the use of skin lightening products in the country...
December 31, 2016: Journal of Public Health in Africa
https://www.readbyqxmd.com/read/28293522/a-case-report-of-the-first-nonburn-related-military-trauma-victim-treated-with-spray-skin-regenerative-therapy-in-combination-with-a-dermal-regenerate-template
#20
Ian L Valerio, Daniel A Hammer, Juan L Rendon, Kerry P Latham, Mark E Fleming
Massive soft tissue and skin loss secondary to war-related traumas are among the most frequently encountered challenges in the care of wounded warriors. This case report outlines the first military nonburn-related trauma patient treated by a combination of regenerative modalities. Our case employs spray skin technology to an established dermal regenerate matrix. Our patient, a 29-year-old active duty male, suffered a combat blast trauma in 2010 while deployed. The patient's treatment course was complicated by a severe necrotizing fasciitis infection requiring over 100 surgical procedures for disease control and reconstruction...
December 2016: Plastic and Reconstructive Surgery. Global Open
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