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https://www.readbyqxmd.com/read/28916979/ventral-hernia-repair-with-poly-4-hydroxybutyrate-mesh
#1
Margaret A Plymale, Daniel L Davenport, Adam Dugan, Amanda Zachem, John Scott Roth
BACKGROUND: Biomaterial research has made available a biologically derived fully resorbable poly-4-hydroxybutyrate (P4HB) mesh for use in ventral and incisional hernia repair (VIHR). This study evaluates outcomes of patients undergoing VIHR with P4HB mesh. METHODS: An IRB-approved prospective pilot study was conducted to assess clinical and quality of life (QOL) outcomes for patients undergoing VIHR with P4HB mesh. Perioperative characteristics were defined. Clinical outcomes, employment status, QOL using 12-item short form survey (SF-12), and pain assessments were followed for 24 months postoperatively...
September 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28916253/the-place-of-transanal-endoscopic-surgery-in-the-treatment-of-recto-urethral-fistula
#2
X Serra-Aracil, M Labro-Ciurans, L Mora-Lopez, J Muñoz-Rodriguez, R Martos-Calvo, J Prats-López, S Navarro-Soto
OBJECTIVES: To assess the role of TEO/TEM in recto-urethral fistulas (RUF). RUF may appear after radical prostatectomy. Their treatment represents a challenge; many therapies have been proposed, from conservative to aggressive surgical approaches. Transanal endoscopic surgery (TEO/TEM) is a minimally invasive technique to access the site of the RUF to perform repair. METHODS: Observational study with prospective data collection, conducted between September 2006 and December 2015...
September 12, 2017: Urology
https://www.readbyqxmd.com/read/28901533/characteristics-of-different-mesh-types-for-abdominal-wall-repair-in-an-experimental-model-of-peritonitis
#3
R Kaufmann, A P Jairam, I M Mulder, Z Wu, J Verhelst, S Vennix, L J X Giesen, M C Clahsen-van Groningen, J Jeekel, J F Lange
BACKGROUND: The use of synthetic mesh to repair a potentially contaminated incisional hernia may lead to higher failure rates. A biological mesh might be considered, but little is known about long-term results. Both biological and synthetic meshes were investigated in an experimental model of peritonitis to assess their characteristics in vivo. METHODS: Male Wistar rats were randomized into five groups and peritonitis was induced. A mesh was implanted after 24 h...
September 13, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28882360/local-parastomal-hernia-repair-with-biological-mesh-is-safe-and-effective
#4
Theadore Hufford, Jean-Francois Tremblay, Mohammad Taha Mustafa Sheikh, Slawomir Marecik, John Park, Ina Zamfirova, Kunal Kochar
PURPOSE: The goal of this study was to evaluate the efficacy, morbidity and safety of local parastomal hernia repair using biological mesh. PATIENTS AND METHODS: A retrospective analysis of a prospectively maintained database was performed for parastomal hernia repairs. All patients who underwent local parastomal hernia repair with biological mesh between July 2006 and July 2015 were included in the study. Non-local (laparoscopic or midline incision) procedures were excluded...
August 5, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28881337/surgical-management-of-a-de-garengeot-s-hernia-using-a-biologic-mesh-a-case-report-and-review-of-literature
#5
Amandine Klipfel, Aïna Venkatasamy, Caroline Nicolai, Marie-Noëlle Roedlich, Francis Veillon, Cécile Brigand, Serge Rohr, Benoît Romain
INTRODUCTION: A De Garengeot hernia is a rare form of femoral hernia, where the appendix is found in the herniated sac. This feature is important to report, as both the diagnosis and the treatment are quite challenging in this particular condition. PRESENTATION OF CASE: We report the case of a 77-year-old female presenting with a femoral hernia, containing an incarcerated necrotic vermiform appendix (De Garengeot hernia). A laparoscopic appendectomy was performed and the herniated defect was repaired according to Rives technique, using a biological mesh...
August 18, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28874611/how-should-aerosols-be-delivered-during-invasive-mechanical-ventilation
#6
Rajiv Dhand
The delivery of aerosols to mechanically ventilated patients presents unique challenges and differs from inhaled drug delivery in spontaneously breathing patients in several respects. Successful aerosol delivery during invasive mechanical ventilation requires careful consideration of a host of factors that influence the amount of drug inhaled by the patient. Pressurized metered-dose inhalers and nebulizers (jet, ultrasonic, and vibrating mesh) are the most commonly used aerosol delivery devices in these patients, although other delivery devices, such as dry powder inhalers, soft mist inhalers, and intratracheal nebulizing catheters, could also be adapted for in-line use...
September 5, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28871666/transperineal-rectocele-repair-a-systematic-review
#7
REVIEW
Eleanor F Zimmermann, Richard S Hayes, Ian R Daniels, Neil J Smart, Andrea M Warwick
BACKGROUND: Transperineal rectocele repairs, either as isolated fascial repair or in combination with mesh augmentation, are hypothesized to reduce the risk of complications compared with alternative techniques. AIM: The aim of this study was to ascertain long-term success and complication rates following transperineal rectocele repairs. METHOD: A literature search of PubMed and Embase was performed using the terms 'transperineal rectocele', 'rectocele', 'transperineal' and 'repair'...
September 4, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28866533/instant-construction-and-visualization-of-crowded-biological-environments
#8
Tobias Klein, Ludovic Autin, Barbora Kozlikova, David S Goodsell, Arthur Olson, M Eduard Groller, Ivan Viola
We present the first approach to integrative structural modeling of the biological mesoscale within an interactive visual environment. These complex models can comprise up to millions of molecules with defined atomic structures, locations, and interactions. Their construction has previously been attempted only within a non-visual and non-interactive environment. Our solution unites the modeling and visualization aspect, enabling interactive construction of atomic resolution mesoscale models of large portions of a cell...
August 29, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28864251/living-nanofiber-yarn-based-woven-biotextiles-for-tendon-tissue-engineering-using-cell-tri-culture-and-mechanical-stimulation
#9
Shaohua Wu, Ying Wang, Philipp N Streubel, Bin Duan
Non-woven nanofibrous scaffolds have been developed for tendon graft application by using electrospinning strategies. However, electrospun nanofibrous scaffolds face some obstacles and limitations, including suboptimal scaffold structure, weak tensile and suture-retention strengths, and compact structure for cell infiltration. In this work, a novel nanofibrous, woven biotextile, fabricated based on electrospun nanofiber yarns, was implemented as a tissue engineered tendon scaffold. Based on our modified electrospinning setup, polycaprolactone (PCL) nanofiber yarns were fabricated with reproducible quality, and were further processed into plain-weaving fabrics interlaced with polylactic acid (PLA) multifilaments...
August 30, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28855424/cell-derived-extracellular-matrix-fibers-synthesized-using-sacrificial-hollow-fiber-membranes
#10
Kevin Roberts, Jacob Schluns, Addison Walker, Jake D Jones, Kyle P Quinn, Jamie Hestekin, Jeffrey C Wolchok
The therapeutic potential of biological scaffolds as adjuncts to synthetic polymers motivates the engineering of fibers formed using the extracellular matrix (ECM) secreted by cells. To capture the ECM secreted by cells during in vitro culture, a solvent degradable hollow fiber membrane (HFM) was created and utilized as a cell culture platform. 3T3 fibroblasts were injected into the narrow (0.986 ± 0.042 mm) lumina of mesoporous polysulfone HFMs and maintained in culture for up to three weeks. Following cell culture, HFMs were dissolved using NMP solvent and the accumulated ECM was collected...
August 31, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28840830/mesh-materials-and-hernia-repair
#11
Santhini Elango, Sakthivel Perumalsamy, Krishnakumar Ramachandran, Ketankumar Vadodaria
Hernia incidence has been observed since ancient time. Advancement in the medical textile industry came up with the variety of mesh materials to repair hernia, but none of them are without complications including recurrence of hernia. Therefore individuals once developed with the hernia could not lead a healthy and comfortable life. This drawn attention of surgeons, patients, researchers and industry to know the exact mechanism behind its development, complications and recurrence. Recent investigations highlighted the role of genetic factors and connective tissue disorders being the reason for the development of hernia apart from the abnormal pressure that is known to develop during other disease conditions...
September 2017: BioMedicine
https://www.readbyqxmd.com/read/28838508/postpneumonectomy-bronchopleural-fistula-closure-with-biologic-mesh-and-diaphragm-flap
#12
Usman Ahmad, Maryna Chumakova, Siva Raja, David P Mason, Sudish C Murthy
A 77-year-old man with clinical stage II squamous cell carcinoma underwent right intrapericardial pneumonectomy. After an initially uneventful course he was readmitted with right-sided empyema, bronchopleural fistula, and pulmonary embolus. This was managed with initial resuscitation and anticoagulant agents, followed by debridement and closure of the fistula with biologic mesh reinforced with a pedicled diaphragm muscle flap.
September 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28833397/an-update-on-the-evidence-for-pathogenic-mechanisms-that-may-link-periodontitis-and-diabetes
#13
David Polak, Lior Shapira
AIM: To provide an update of the review by Taylor et al (2013) regarding the scientific evidence of the biological association between periodontitis and diabetes. METHODS: Literature searches were performed using MeSH terms, keywords, and title words and were published between 2012 to November 2016. All publications were screened for their relevance. The data from the articles were extracted and summarized in tables and a narrative review. RESULTS: Small-scale molecular periodontal microbiome studies indicate a possible association between altered glucose metabolism in pre-diabetes and diabetes and changes in the periodontal microbiome, with no evidence for casual relationships...
August 19, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28829367/past-present-and-future-of-surgical-meshes-a-review
#14
REVIEW
Karen Baylón, Perla Rodríguez-Camarillo, Alex Elías-Zúñiga, Jose Antonio Díaz-Elizondo, Robert Gilkerson, Karen Lozano
Surgical meshes, in particular those used to repair hernias, have been in use since 1891. Since then, research in the area has expanded, given the vast number of post-surgery complications such as infection, fibrosis, adhesions, mesh rejection, and hernia recurrence. Researchers have focused on the analysis and implementation of a wide range of materials: meshes with different fiber size and porosity, a variety of manufacturing methods, and certainly a variety of surgical and implantation procedures. Currently, surface modification methods and development of nanofiber based systems are actively being explored as areas of opportunity to retain material strength and increase biocompatibility of available meshes...
August 22, 2017: Membranes
https://www.readbyqxmd.com/read/28822396/an-evaluation-of-parastomal-hernia-repair-using-the-americas-hernia-society-quality-collaborative
#15
MULTICENTER STUDY
Sarah S Fox, Randy Janczyk, Jeremy A Warren, Alfredo M Carbonell, Benjamin K Poulose, Michael J Rosen, William W Hope
The purpose of this review was to evaluate outcomes relating to parastomal hernia repair. Data from the Americas Hernia Society Quality Collaborative were used to identify patients undergoing parastomal hernia repair from 2013 to 2016. Parastomal hernia repairs were compared with other repairs using Pearson's test and Wilcoxon test with a P value <0.05 considered significant. Parastomal hernia repairs were performed in 311 patients. Techniques of repair include open in 85 per cent and laparoscopic in 15 per cent...
August 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28812124/clozapine-chlorpromazine-and-risperidone-dose-dependently-reduce-emotional-hyperthermia-a-biological-marker-of-salience
#16
William W Blessing, Esther M Blessing, Mazher Mohammed, Youichirou Ootsuka
RATIONALE: We recently introduced a new rat model of emotional hyperthermia in which a salient stimulus activates brown adipose tissue (BAT) thermogenesis and tail artery constriction. Antipsychotic drugs, both classical and second generation, act to reduce excessive assignment of salience to objects and events in the external environment. The close association between salient occurrences and increases in body temperature suggests that antipsychotic drugs may also reduce emotional hyperthermia...
August 15, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28808960/the-application-of-humanized-mouse-models-for-the-study-of-human-exclusive-viruses
#17
Fatemeh Vahedi, Elizabeth C Giles, Ali A Ashkar
The symbiosis between humans and viruses has allowed human tropic pathogens to evolve intricate means of modulating the human immune response to ensure its survival among the human population. In doing so, these viruses have developed profound mechanisms that mesh closely with our human biology. The establishment of this intimate relationship has created a species-specific barrier to infection, restricting the virus-associated pathologies to humans. This specificity diminishes the utility of traditional animal models...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28806146/three-dimensional-bioprinting-of-polycaprolactone-reinforced-gene-activated-bioinks-for-bone-tissue-engineering
#18
Gráinne M Cunniffe, Tomas Gonzalez-Fernandez, Andrew Daly, Binulal N Sathy, Oju Jeon, Eben Alsberg, Daniel J Kelly
Regeneration of complex bone defects remains a significant clinical challenge. Multi-tool biofabrication has permitted the combination of various biomaterials to create multifaceted composites with tailorable mechanical properties and spatially controlled biological function. In this study we sought to use bioprinting to engineer nonviral gene activated constructs reinforced by polymeric micro-filaments. A gene activated bioink was developed using RGD-γ-irradiated alginate and nano-hydroxyapatite (nHA) complexed to plasmid DNA (pDNA)...
August 14, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28778063/coaxial-electrospun-pcl-gelatin-ma-fibers-as-scaffolds-for-vascular-tissue-engineering
#19
P Coimbra, P Santos, P Alves, Sónia P Miguel, Marco P Carvalho, Kevin D de Sá, I J Correia, P Ferreira
Coaxial electrospinning is a technique that allows the production of nanofibers with a core-shell structure. Such fibers present several advantages as materials for the preparation of scaffolds, namely due to the possibility of combining a core with the desired mechanical properties with a shell prepared from biocompatible materials that will establish proper interactions with the host. Herein, core-shell fibrous meshes, composed of a polycaprolactone (PCL) core and a functionalized gelatin shell, were prepared by coaxial electrospinning and then photocrosslinked under UV light aiming to be used in vascular tissue regeneration...
July 26, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28774442/computational-modeling-for-prediction-of-the-shear-stress-of-three-dimensional-isotropic-and-aligned-fiber-networks
#20
Seungman Park
BACKGROUND AND OBJECTIVE: Interstitial flow (IF) is a creeping flow through the interstitial space of the extracellular matrix (ECM). IF plays a key role in diverse biological functions, such as tissue homeostasis, cell function and behavior. Currently, most studies that have characterized IF have focused on the permeability of ECM or shear stress distribution on the cells, but less is known about the prediction of shear stress on the individual fibers or fiber networks despite its significance in the alignment of matrix fibers and cells observed in fibrotic or wound tissues...
September 2017: Computer Methods and Programs in Biomedicine
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