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JOURNAL ARTICLE
Shanea M P Gibson, Tiffany A Hunter, Phillip E Charles, Melonie A C Morgan, Shari K R Griffith-Anderson, J Kennedy Cruickshank, Maxine D Gossell-Williams, Nadine A Johnson
OBJECTIVES: Sickle cell disease (SCD) occurs in 2.8 % of our Jamaican antenatal population with homozygous HbSS being most associated with adverse maternal and perinatal outcomes. METHODS: A retrospective comparative analysis of HbSS, HbSC and HbSβThal pregnancy outcomes at the University Hospital of the West Indies (UHWI) between January 2012 and December 2022 was conducted. RESULTS: Of 120 patients (138 pregnancies), obesity occurred in 36 % (20/56) of the 'non-HbSS' group, i...
April 18, 2024: Journal of Perinatal Medicine
#2
JOURNAL ARTICLE
Jingang Yang, Yanyan Zhao, Jianyi Wang, Liyuan Ma, Haiyan Xu, Wenxiu Leng, Yang Wang, Yan Wang, Zhifang Wang, Xiaojin Gao, Yuejin Yang
BACKGROUND: The mortality rate of myocardial infarction in China has increased dramatically in the past three decades. Although emergency medical service (EMS) played a pivotal role for the management of patients with ST-segment elevation myocardial infarction (STEMI), the corresponding data in China are limited. METHODS: An observational analysis was performed in 26,305 STEMI patients, who were documented in China acute myocardial infarction (CAMI) Registry and treated in 162 hospitals from January 1st, 2013 to January 31th, 2016...
April 11, 2024: International Journal of Cardiology
#3
JOURNAL ARTICLE
Kelsen Dantas Eulálio, Daniel R Kollath, Liline Maria Soares Martins, Antonio de Deus Filho, Maria do Amparo Salmito Cavalcanti, Lucas Machado Moreira, Bernardo Guerra Tenório, Lucas Gomes de Brito Alves, Danielle Yamauchi, Ligia Vizeu Barrozo, George R Thompson Iii, Mathieu Nacher, Jason E Stajich, Gil Benard, Eduardo Bagagli, Maria Sueli Soares Felipe, Bridget M Barker, Luciana Trilles, Marcus de Melo Teixeira
Coccidioidomycosis, listed as a priority mycosis by the WHO, is endemic in the United States but often overlooked in Central and South America. Employing a multi-institutional approach, we investigate how disease characteristics, pathogen genetic variation, and environmental factors impact coccidioidomycosis epidemiology and outcomes in South America. We identified 292 cases (1978-2021) and 42 outbreaks in Piauí and Maranhão states, Brazil, the largest series outside the US/Mexico epidemic zone. The male-to-female ratio was 57...
April 12, 2024: Nature Communications
#4
JOURNAL ARTICLE
Juan José Bosch Fragueiro, María Macarena Iudica
UNLABELLED: Pulmonary cryptococcosis is a lung infection caused by the Cryptococcus yeast. It is rare in pediatrics, especially in immunocompetent children. The diagnosis of pulmonary cryptococcosis can be challenging due to the low specificity of symptoms, low index of suspicion, and limited diagnostic resources. OBJECTIVE: To describe a clinical case of pulmonary cryptococcosis in an immunocompetent adolescent, detailing the diagnostic approach. CLINICAL CASE: A 15-year-old patient, previously healthy, from a rural town, who consulted due to cough and a 1-month rib stitch pain, without fever or associated respiratory difficulty, with two images of condensation in the left lung on the chest x-ray...
February 2024: Andes pediatrica: revista Chilena de pediatría
#5
JOURNAL ARTICLE
Amit Saha, Shuang Li, James A de Lemos, Ambarish Pandey, Deepak L Bhatt, Gregg C Fonarow, Brahmajee K Nallamothu, Tracy Y Mhs WangMSc, Ann Marie Navar, Eric Peterson, Roland A Matsouaka, Anthony A Bavry, Sandeep R Das, Justin L Grodin, Rohan Khera, Mark H Drazner, Dharam J Kumbhani
Cardiogenic shock after acute myocardial infarction (AMI-CS) carries significant mortality despite advances in revascularization and mechanical circulatory support. We sought to identify process-based and structural characteristics of centers with lower mortality in AMI-CS. We analyzed 16,337 AMI-CS cases across 440 centers enrolled in the Chest Pain-MI Registry, a retrospective cohort database, between January 1, 2015, and December 31, 2018. Centers were stratified across tertiles of risk-adjusted in-hospital mortality rate (RAMR) for comparison...
April 5, 2024: American Journal of Cardiology
#6
JOURNAL ARTICLE
Daniel Lorenzatti, Pamela Piña, Dou Huang, Samuel J Apple, Carol Fernandez-Hazim, Paul Ippolito, Aftab Abdullah, Miguel Rodriguez-Guerra, John P Skendelas, Andrea Scotti, Toshiki Kuno, Azeem Latib, Aldo L Schenone, Khurram Nasir, Ron Blankstein, Michael J Blaha, Daniel S Berman, Damini Dey, Salim S Virani, Mario J Garcia, Leandro Slipczuk
AIMS: The atherosclerotic profile and advanced plaque subtype burden in symptomatic patients ≤45 years old have not been established. This study aimed to assess the prevalence and predictors of coronary artery calcium (CAC), plaque subtypes, and plaque burden by coronary computed tomography angiography (CCTA) in symptomatic young patients. METHODS AND RESULTS: We included 907 symptomatic young patients (18-45 years) from Montefiore undergoing CCTA for chest pain evaluation...
April 5, 2024: European Heart Journal Cardiovascular Imaging
#7
JOURNAL ARTICLE
Patrik Gilje, Moman A Mohammad, Andreas Roos, Ulf Ekelund, Jonas Björk, Bertil Lindahl, Martin Holzmann, Arash Mokhtari
BACKGROUND: Ruling out acute myocardial infarction (AMI) in the emergency department (ED) is challenging. Studies have shown that a high-sensitivity cardiac troponin T (hs-cTnT) <5 ng/L or <6 ng/L at presentation (0 h) can be used to rule out AMI. The objective of this study was to identify whether an even higher hs-cTnT threshold can be used for a safe rule out of AMI in the ED. METHODS: The derivation cohort consisted of 24,973 ED patients with a primary complaint of chest pain...
2024: Emergency Medicine International
#8
JOURNAL ARTICLE
Mahbobeh VatanKhah, Javad Malekzadeh, Mohammad-Davood Sharifi, Amir Mirhaghi
INTRODUCTION: The diagnostic evaluation of the emergency severity index (ESI) in the triage of patients with cardiopulmonary complaints has a high sensitivity but a low specificity in the emergency department (ED). Therefore, triage scales with more accurate diagnostic evaluation are required. As a result, accuracy of the SINEH triage scale (SinTS) and the ESI was compared to compare mistriage of critically ill patients with cardiopulmonary complaints. METHODS: This descriptive, analytical and cross-sectional study was conducted between December 2022 and April 2023...
2024: Emergency Medicine International
#9
Connor M O'Rielly, James E Andruchow, Andrew D McRae
No abstract text is available yet for this article.
March 25, 2024: CJEM
#10
JOURNAL ARTICLE
Paramjit Kaur, Syed Fatmi, Emmanuel Tangco, Elise E Zhao, Fateeha Tariq, Sanjida Jahan, Kristy Johnson Pich, Darius Aliabadi
BACKGROUND: Global longitudinal strain (GLS) imaging is a multifaceted modality that has been utilized in various fields of clinical cardiology in the recent past; however, its implementation for the assessment of ischemia has been limited. OBJECTIVES: This study aimed to document the functional changes in GLS secondary to acute myocardial ischemia in patients with chronic chest pain. METHODS: In this unblinded, single-center, investigator-initiated, prospective pilot study, the functional changes in GLS at baseline, during, and immediately following coronary percutaneous intervention were monitored in 10 ambulatory patients who underwent elective catheterization...
January 2024: American heart journal plus: cardiology research and practice
#11
JOURNAL ARTICLE
Peter Loof Møller, Palle Duun Rohde, Jonathan Nørtoft Dahl, Laust Dupont Rasmussen, Louise Nissen, Samuel Emil Schmidt, Victoria McGilligan, Daniel F Gudbjartsson, Kari Stefansson, Hilma Holm, Jacob Fog Bentzon, Morten Bøttcher, Simon Winther, Mette Nyegaard
BACKGROUND: The presence of coronary plaques with high-risk characteristics is strongly associated with adverse cardiac events beyond the identification of coronary stenosis. Testing by coronary computed tomography angiography (CCTA) enables the identification of high-risk plaques (HRP). Referral for CCTA is presently based on pre-test probability estimates including clinical risk factors (CRFs); however, proteomics and/or genetic information could potentially improve patient selection for CCTA and, hence, identification of HRP...
March 20, 2024: Genome Medicine
#12
JOURNAL ARTICLE
Murat Gol, Nurseli Bayram, Oguzhan Demir, Sinan Karacabey, Erkman Sanri
OBJECTIVE: We aimed to compare the predictive ability of the newly introduced Symptoms, history of Vascular disease, Electrocardiography, Age, and Troponin (SVEAT) score with the widely used History, ECG, Age, Risk factors, and Troponin I (HEART) score in risk stratification for 30-day major adverse cardiac events (MACE) development among patients presenting to the emergency department with acute chest pain complaints. METHODS: This prospective, observational, single-center study was conducted at an emergency department of a tertiary care hospital between June 2022 and January 2023...
March 7, 2024: American Journal of Emergency Medicine
#13
REVIEW
Virginia Zarama, María Camila Arango-Granados, Ramiro Manzano-Nunez, James P Sheppard, Nia Roberts, Annette Plüddemann
BACKGROUND: Chest pain is responsible for millions of visits to the emergency department (ED) annually. Cardiac ultrasound can detect ischemic changes, but varying accuracy estimates have been reported in previous studies. We synthetized the available evidence to yield more precise estimates of the accuracy of cardiac ultrasound for acute myocardial ischemia in patients with chest pain in the ED and to assess the effect of different clinical characteristics on test accuracy. METHODS: A systematic search for studies assessing the diagnostic accuracy of cardiac ultrasound for myocardial ischemia in the ED was conducted in MEDLINE, EMBASE, CENTRAL, CINAHL, LILACS, Web of Science, two trial registries and supplementary methods, from inception to December 6th, 2022...
March 11, 2024: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
#14
JOURNAL ARTICLE
Matthias Michal, Jörg Wiltink, Ana N Tibubos, Philipp S Wild, Thomas Münzel, Karl Lackner, Norbert Pfeiffer, Jochem König, Alexander Gieswinkel, Manfred Beutel, Jasmin Ghaemi Kerahrodi
BACKGROUND: Symptoms of depersonalization (DP) and derealization (DR) are a risk factor for more severe impairment, non-response to various treatments, and a chronic course. In this study, we investigated the effects of DP/DR symptoms in patients with clinically significant depressive symptoms on clinical characteristics and various outcomes in a representative population-based sample with a 5-year follow-up. METHODS: The middle-aged sample comprised n = 10,422 persons at baseline, of whom n = 9,301 were free from depressive and DP/DR symptoms...
March 8, 2024: BMC Psychiatry
#15
RANDOMIZED CONTROLLED TRIAL
Federico Biavati, Luca Saba, Melinda Boussoussou, Klaus F Kofoed, Theodora Benedek, Patrick Donnelly, José Rodríguez-Palomares, Andrejs Erglis, Cyril Štěchovský, Gintarė Šakalytė, Nada Čemerlić Ađić, Matthias Gutberlet, Jonathan D Dodd, Ignacio Diez, Gershan Davis, Elke Zimmermann, Cezary Kępka, Radosav Vidakovic, Marco Francone, Małgorzata Ilnicka-Suckiel, Fabian Plank, Juhani Knuuti, Rita Faria, Stephen Schröder, Colin Berry, Balazs Ruzsics, Nina Rieckmann, Christine Kubiak, Kristian Schultz Hansen, Jacqueline Müller-Nordhorn, Pál Maurovich-Horvat, Per E Sigvardsen, Imre Benedek, Clare Orr, Filipa Xavier Valente, Ligita Zvaigzne, Vojtěch Suchánek, Antanas Jankauskas, Filip Ađić, Michael Woinke, Diarmaid Cadogan, Iñigo Lecumberri, Erica Thwaite, Mariusz Kruk, Aleksandar N Neskovic, Massimo Mancone, Donata Kuśmierz, Gudrun Feuchtner, Mikko Pietilä, Vasco Gama Ribeiro, Tanja Drosch, Christian Delles, Riccardo Cau, Michael Fisher, Bela Merkely, Charlotte Kragelund, Rosca Aurelian, Stephanie Kelly, Bruno García Del Blanco, Ainhoa Rubio, Bálint Szilveszter, Jens D Hove, Ioana Rodean, Susan Regan, Hug Cuéllar Calabria, István Ferenc Édes, Linnea Larsen, Roxana Hodas, Adriane E Napp, Robert Haase, Sarah Feger, Mahmoud Mohamed, Lina M Serna-Higuita, Konrad Neumann, Henryk Dreger, Matthias Rief, Viktoria Wieske, Matthew J Budoff, Melanie Estrella, Peter Martus, Maria Bosserdt, Marc Dewey
Background Coronary artery calcium (CAC) has prognostic value for major adverse cardiovascular events (MACE) in asymptomatic individuals, whereas its role in symptomatic patients is less clear. Purpose To assess the prognostic value of CAC scoring for MACE in participants with stable chest pain initially referred for invasive coronary angiography (ICA). Materials and Methods This prespecified subgroup analysis from the Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease (DISCHARGE) trial, conducted between October 2015 and April 2019 across 26 centers in 16 countries, focused on adult patients with stable chest pain referred for ICA...
March 2024: Radiology
#16
JOURNAL ARTICLE
Zhe Wang, Jiawei Chen, Hehe Guo, Jiaju Li, Lichen Ren, Xiaojie Chen, Liping Sun, Yingwei Chen
BACKGROUND: Large epicardial adipose tissue (EAT) volume is associated with the incidence of premature ventricular beats. The relationship between EAT volume and idiopathic ventricular tachycardia (IVT) is not yet clear. We aimed to investigate the effect of EAT volume on the risk of IVT. METHODS: This is a retrospective consecutive case-control study from January 2020 to September 2022. IVT patients (n=81) and control patients (n=162) undergoing coronary computed tomography angiography (CCTA) were retrospectively recruited...
February 15, 2024: Cardiovascular Diagnosis and Therapy
#17
Beatriz Chambino, Cláudio Gouveia, Cristiana Camacho, Antony Dionisio, Ana Margarida Ribeiro, Célia Henriques
A renal infarction occurs when kidney's arterial blood supply is compromised, causing parenchymal necrosis and loss of function. It is a relatively uncommon complication and its treatment is time-dependent. We present a case where a female patient with a history of bilateral aortic-iliac stenting over 10 years before presented with chest pain, palpitations, and dyspnea associated with hypertension. The patient progressed with an acute worsening of renal function and anuria, with an urgent need for renal replacement therapy...
January 2024: Curēus
#18
JOURNAL ARTICLE
J H Zhou, Y L Zhang, L F Li, P L Lu
Objective: To explore the role of prognostic nutritional index (PNI) and pleural thickness in the prognostic evaluation of patients with epithelial malignant pleural mesothelioma (MPM) . Methods: In April 2022, a retrospective analysis was conducted on the data and laboratory data of 41 patients with epithelial MPM admitted to the cardiothoracic surgery department of Chuxiong Yi Autonomous Prefecture People's Hospital from January 2018 to May 2021. Univariate and multivariate analysis were used to evaluate the relationships between total survival time, clinical characteristics, PNI and pleural thickness in patients...
February 20, 2024: Chinese Journal of Industrial Hygiene and Occupational Diseases
#19
JOURNAL ARTICLE
Braylee Grisel, Olanrewaju Adisa, Francis M Sakita, Tumsifu G Tarimo, Godfrey L Kweka, Jerome J Mlangi, Amedeus V Maro, Marilyn Yamamoto, Lauren Coaxum, David Arthur, Alexander T Limkakeng, Julian T Hertz
OBJECTIVE: The HEART score successfully risk stratifies emergency department (ED) patients with chest pain in high-income settings. However, this tool has not been validated in low-income countries. METHODS: This is a secondary analysis of a prospective observational study that was conducted in a Tanzanian ED from January 2019 through January 2023. Adult patients with chest pain were consecutively enrolled, and their presenting symptoms and medical history were recorded...
February 23, 2024: Academic Emergency Medicine
#20
JOURNAL ARTICLE
Stefan Mülverstedt, Eva Irene Bossano Prescott, Henrik Jørgensen, Merete Heitmann
OBJECTIVES: Patients with familial hypercholesterolaemia (FH) are genetically burdened by a lifelong elevation of the low-density lipoprotein cholesterol (LDL-C) level, putting them at a very high risk of premature ischaemic heart disease (IHD). This study aims to assess the prevalence of FH among patients admitted for IHD and the preventive treatment status before admission. DESIGN: Observational, retrospective, register-based study. SETTING: Individuals discharged with a diagnosis of IHD were enrolled consecutively throughout 2012-2016 from the cardiac care units of two hospitals in Copenhagen...
February 22, 2024: BMJ Open
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