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Her2 breast cancer

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https://www.readbyqxmd.com/read/29924962/prognostic-value-of-aldehyde-dehydrogenase-1-aldh1-in-invasive-breast-carcinomas
#1
Hale Demir, Ozgecan Dulgar, Bugra Taygun Gulle, Hande Turna, Sennur Ilvan
Aldehyde dehydrogenase 1 (ALDH1) has been identified as a marker of cancer stem cells in breast cancer (BC). Recent studies showed that ALDH1 expression is correlated with poor prognostic parameters and worse clinical outcome in BC. We evaluated ALDH1 expression by immunohistochemistry in a series of 217 invasive BCs and investigated the correlation between ALDH1 expression and clinicopathological parameters, molecular subtypes (luminal A, luminal B, human epidermal growth factor receptor 2 [HER2] type, and triple-negative BC [TNBC]), and patient survival...
June 11, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29923906/comparative-pathologic-analysis-of-breast-cancers-classified-as-her2-neu-amplified-by-fish-using-a-standard-her2-cep17-dual-probe-and-an-alternative-chromosome-17-control-probe
#2
Somaye Zare, Leo Lin, Abrar G Alghamdi, Svenja Daehne, Andres A Roma, Farnaz Hasteh, Marie Dell'Aquila, Oluwole Fadare
At our institution, breast cancer cases that generate an equivocal HER2/neu (HER2) result by fluorescence in situ hybridization (FISH) using the dual HER2/chromosome enumeration probe (CEP17) are reflexed to an assay that utilizes an alternative control probe (lissencephaly gene1 [LIS1] [17p13.3]/retinoic acid receptor α [RARA] [17q21.2]). This study examines whether cancers that are classified as HER2-amplified with an alternate probe are clinicopathologically similar to those that are classified as such using the HER2/CEP17 probe...
June 19, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29923614/high-turnover-of-extracellular-matrix-reflected-by-specific-protein-fragments-measured-in-serum-is-associated-with-poor-outcomes-in-two-metastatic-breast-cancer-cohorts
#3
Allan Lipton, Kim Leitzel, Suhail M Ali, Hyma V Polimera, Vinod Nagabhairu, Eric Marks, Angelique E Richardson, Laura Krecko, Ayesha Ali, Wolfgang Koestler, Francisco J Esteva, Diana J Leeming, Morten A Karsdal, Nicholas Willumsen
Increased extracellular matrix (ECM) formation and matrix metalloprotease (MMP)-mediated ECM degradation are parts of tumorgenesis and generates specific collagen fragments that are released into circulation. We evaluated the association of specific collagen fragments measured in serum with outcomes in two independent metastatic breast cancer (MBC) cohorts. ELISAs were used to measure C1M (MMP-generated type I collagen fragment), C3M (MMP-generated type III collagen fragment), C4M (MMP-generated type IV collagen fragment), and PRO-C3 (pro-peptide of type III collagen) in pre-treatment serum from a phase 3 randomized clinical trial of 2nd -line hormone therapy (HR+, n= 148), and a 1st -line trastuzumab-treated cohort (HER2+, n=55)...
June 20, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29923341/organochlorine-pesticide-residues-in-human-breast-tissue-and-their-relationships-with-clinical-and-pathological-characteristics-of-breast-cancer
#4
Rachel E Ellsworth, Paul J Kostyniak, Lai-Har Chi, Craig D Shriver, Nicholas S Costantino, Darrell L Ellsworth
Agricultural pesticides are abundant environmental contaminants worldwide, prompting interest in studying their possible detrimental health effects. We examined organochlorine residues by quadrant (n = 245) in breast adipose tissues from 51 women with various stages of breast health to determine patterns of bioaccumulation within the breast and to assess relationships with patient clinical characteristics. Three organochlorine residues-2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (p,p'-DDE), hexachlorobenzene (HCB), and mirex-assayed by high resolution gas chromatography were abundant in breast tissue...
June 19, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29921827/differential-expression-and-pathway-analysis-in-drug-resistant-triple-negative-breast-cancer-cell-lines-using-rnaseq-analysis
#5
Safa Shaheen, Febin Fawaz, Shaheen Shah, Dietrich Büsselberg
Triple-negative breast cancer (TNBC) is among the most notorious types of breast cancer, the treatment of which does not give consistent results due to the absence of the three receptors (estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) as well as high amount of molecular variability. Drug resistance also contributes to treatment unresponsiveness. We studied differentially expressed genes, their biological roles, as well as pathways from RNA-Seq datasets of two different TNBC drug-resistant cell lines of Basal B subtype SUM159 and MDA-MB-231 treated with drugs JQ1 and Dexamethasone, respectively, to elucidate the mechanism of drug resistance...
June 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29921729/integrating-radiosensitivity-and-immune-gene-signatures-for-predicting-benefit-of-radiotherapy-in-breast-cancer
#6
Yi Cui, Bailiang Li, Erqi Liu Pollom, Kathleen Horst, Ruijiang Li
PURPOSE: Breast cancer is a heterogeneous disease and not all patients respond equally to adjuvant radiotherapy. Predictive biomarkers are needed to select patients who will benefit from the treatment and spare others the toxicity and burden of radiation. EXPERIMENTAL DESIGN: We first trained and tested an intrinsic radiosensitivity gene signature to predict local recurrence after radiotherapy in three cohorts of 948 patients. Next, we developed an antigen processing and presentation-based immune signature by maximizing the treatment interaction effect in 129 patients...
June 19, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29921380/different-molecular-subtypes-of-breast-invasive-ductal-carcinoma
#7
L J Zheng, D Yang, L J Sun, S S Li, J Y Wang, S C Ye
This study aims to analyze the clinical characteristics of breast invasive ductal carcinoma (BIDC) in patients with different molecular subtypes and identify possible correlation to prognosis. miR- 10b expression level was detected using real-time quantitative polymerase chain reaction (RT-PCR). Tissue sections were collected and stained using the immunohistochemical method. The samples were grouped into human epidermal growth factor receptor 2, (HER2) overexpression, Triple negative, Luminal A and Luminal B groups...
May 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29920138/her2-testing-in-breast-cancer-american-society-of-clinical-oncology-college-of-american-pathologists-clinical-practice-guideline-focused-update-summary
#8
Antonio C Wolff, M Elizabeth Hale Hammond, Kimberly H Allison, Brittany E Harvey, Lisa M McShane, Mitchell Dowsett
No abstract text is available yet for this article.
June 19, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29916188/new-horizons-in-breast-cancer-the-promise-of-immunotherapy
#9
REVIEW
L de la Cruz-Merino, N Palazón-Carrión, F Henao-Carrasco, E Nogales-Fernández, M Álamo-de la Gala, A Vallejo-Benítez, M Chiesa, V Sánchez-Margalet
Immunology and immunotherapy of cancer is an expanding field in oncology, with recent great achievements obtained through the new successful approaches implemented to circumvent immune evasion, which is undoubtedly considered a novel hallmark of cancer. Translational research in this topic has revealed targets that can be modulated in the clinical setting with new compounds and strategies. Like most of the tumors, breast cancer is considered a complex and heterogeneous disease in which host immune responses have been also recently demonstrated of critical relevance...
June 18, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29916008/heterogeneity-in-outcomes-of-pathologic-t1-2n1-breast-cancer-after-mastectomy-looking-beyond-locoregional-failure-rates
#10
Jose G Bazan, Lonika Majithia, Allison M Quick, Jessica L Wobb, Alicia M Terando, Doreen M Agnese, William Farrar, Julia R White
PURPOSE: A meta-analysis of 22 randomized trials accrued from 1964 to 1986 demonstrated significantly higher rates of locoregional failure (LRF) and breast-cancer mortality in women with 1-3 positive nodes without postmastectomy radiotherapy (PMRT) after mastectomy (mast.). Recent data demonstrate that PMRT reduces distant metastases (DM) in women with pN1 disease. The challenge today is whether all patients with pathologic T1-2pN1 disease have similar substantial LRF/DM risk that routinely warrants PMRT...
June 18, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29915982/a-continuous-time-multistate-markov-model-to-describe-the-occurrence-and-severity-of-diarrhea-events-in-metastatic-breast-cancer-patients-treated-with-lumretuzumab-in-combination-with-pertuzumab-and-paclitaxel
#11
Chao Xu, Patanjali Ravva, Jun Steve Dang, Johann Laurent, Céline Adessi, Christine McIntyre, Georgina Meneses-Lorente, François Mercier
PURPOSE: To inform lumretuzumab and pertuzumab dose modifications in order to decrease the incidence, severity, and duration of the diarrhea events in metastatic breast cancer patients treated with a combination therapy of lumretuzumab (anti-HER3) in combination with pertuzumab (anti-HER2) and paclitaxel using quantitative clinical pharmacology modeling approaches. METHODS: The safety and pharmacokinetic (PK) data from three clinical trials (lumretuzumab monotherapy n = 47, pertuzumab monotherapy n = 78, and the combination therapy of lumretuzumab, pertuzumab and paclitaxel n = 35) were pooled together to develop a continuous-time discrete states Markov model describing the dynamics of the diarrhea events...
June 18, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29915946/impact-of-change-in-body-mass-index-during-neoadjuvant-chemotherapy-and-survival-among-breast-cancer-subtypes
#12
Takahiro Kogawa, Takeo Fujii, Tamer M Fouad, Diane D Liu, Kenichi Harano, Hiroko Masuda, Toshiaki Iwase, Chad Barnett, Young Sam Park, Bora Lim, Debu Tripathy, Jennifer K Litton, Naoto T Ueno
PURPOSE: We hypothesized that an increase in BMI category during neoadjuvant chemotherapy (NAC) would be associated with pathological complete response (pCR) rate and worse survival outcomes in primary breast cancer patients. METHODS: We reviewed the records of 4029 patients with stage I-III breast cancer who had undergone NAC and definitive surgery at our institution between May 1, 1990 and April 30, 2013. BMI values at baseline and after NAC were recorded, and the corresponding BMI category was assessed with the WHO classification...
June 18, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29915439/%C3%AF-editors-choice%C3%AF-practice-management-for-elderly-patients-with-breast-cancer-findings-from-a-survey-by-the-japan-breast-cancer-study-group
#13
Masataka Sawaki, Kenji Tamura, Akihiko Shimomura, Yumiko Taki, Fumio Nagashima, Hiroji Iwata
Information on patterns of clinical care for elderly breast cancer patients is lacking. The aims of this study are two-fold, firstly, to clarify daily practice treatments for elderly breast cancer patients in Japan, and secondly, to plan a prospective clinical trial to address unresolved clinical questions. We investigated practice care of elderly breast cancer patients in 38 institutions of the Japan Clinical Oncology Group (JCOG). Questionnaires asked: (1) definition of "elderly" for each treatment, (2) clinical standard anti-HER2 therapy in each age-group, (3) recommended docetaxel dose in each age-group, (4) considerations for future clinical trials, and (5) other information about geriatric oncology concerning breast cancer...
May 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29914420/low-expression-of-recql-is-associated-with-poor-prognosis-in-chinese-breast-cancer-patients
#14
Huiying Xu, Ye Xu, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie
BACKGROUND: RECQL is a number of the RecQ DNA helicase family and plays an important role in maintaining genome stability. Although several studies have reported that RECQL mutations were correlated with the susceptibility to breast cancer, the effect on prognosis in breast cancer was not yet clarified. Here, we explored the association between RECQL expression level and survival in patients with breast cancer. METHODS: In the first cohort, the RECQL mRNA expression level was evaluated in 774 primary breast cancer patients using a quantitative real-time PCR assay...
June 18, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29913459/clinical-characteristics-and-prognosis-of-pregnancy-associated-breast-cancer-poor-survival-of-luminal-b-subtype
#15
Soo Youn Bae, Seung Pil Jung, Eun Sung Jung, Sung Min Park, Se Kyung Lee, Jong Han Yu, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam
BACKGROUND: Pregnancy-associated breast cancer (PABC) is rare and is generally defined as breast cancer diagnosed during pregnancy or within 1 year of delivery. The average ages of marriage and childbearing are increasing, and PABC is expected to also increase. This study is intended to increase understanding of the characteristics of PABC. METHODS: A database of 2,810 patients with breast cancer diagnosed when they were less than 40 years of age was reviewed. The clinicopathological factors and survival of PABC (40 patients) were compared to those of patients with young breast cancer (YBC, non-pregnant or over 12 months after delivery; 2,770 patients)...
June 18, 2018: Oncology
https://www.readbyqxmd.com/read/29913374/fluctuation-of-the-left-ventricular-ejection-fraction-in-patients-with-her2-positive-early-breast-cancer-treated-by-12-months-of-adjuvant-trastuzumab
#16
Quentin Jacquinot, Sophie Paget-Bailly, Pierre Fumoleau, Gilles Romieu, Jean Yves Pierga, Marc Espié, Alain Lortholary, Jean Marc Nabholtz, Celine Faure Mercier, Iris Pauporté, Julie Henriques, Xavier Pivot
BACKGROUND: Cardiac toxicity with a decrease of the left ventricular ejection fraction (LVEF) is the main side effect induced by trastuzumab. This study reports the fluctuation of LVEF over the 12 months of adjuvant trastuzumab in PHARE trial (NCT00381901). METHODS: LVEF assessment was performed every 3 months while patients received trastuzumab and after completion of treatment over the first 2 years and then every 6 months afterwards. The fluctuations of LVEF over time were described and a logistic regression model was performed investigating associated factors to LVEF perfect recovery at baseline value...
June 15, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29911489/interleukin-13-receptor-alpha-2-expression-in-tumor-cells-is-associated-with-reduced-disease-free-survival-in-patients-with-luminal-subtype-invasive-breast-cancer
#17
Hee Jung Kwon, Jung Eun Choi, Young Kyung Bae
Interleukin-13 receptor alpha 2 is one of the subunits of transmembrane receptor for interleukin-13. The aim of this study was to investigate the prognostic value of interleukin-13 receptor alpha 2 expression in invasive breast cancer. Interleukin-13 receptor alpha 2 expressions were assessed by immunohistochemistry in tissue microarrays of 1283 invasive breast cancer samples, and associations between these expressions and clinicopathological variables and clinical outcomes were investigated. Interleukin-13 receptor alpha 2 expression was observed in 138 (10...
June 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29910679/the-suppression-of-dusp5-expression-correlates-with-paclitaxel-resistance-and-poor-prognosis-in-basal-like-breast-cancer
#18
Tieju Liu, Huizhi Sun, Shiqi Liu, Zhao Yang, Linqi Li, Nan Yao, Siqi Cheng, Xueyi Dong, Xiaohui Liang, Chen Chen, Yi Wang, Xiulan Zhao
Basal-like breast cancer (BLBC) is resistant to endocrinotherapy and targeted therapy and new molecular therapies are needed for BLBC. In this study, we evaluated the role of DUSP1 and DUSP5, negative regulators of mitogen-activated protein kinase pathway, in the aggressiveness of BLBC. MDA-MB-231 cells were given paclitaxel (PTX) treatment and subsequently PTX resistant cell clones were established. Microarray analysis, real-time quantitative reverse transcription PCR (qRT-PCR), and online analysis of large cohorts of breast cancer patients were performed...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29910660/the-evolution-of-biosimilars-in-oncology-with-a-focus-on-trastuzumab
#19
N A Nixon, M B Hannouf, S Verma
Cancer therapy has evolved significantly with increased adoption of biologic agents ("biologics"). That evolution is especially true for her2 (human epidermal growth factor receptor-2)-positive breast cancer with the introduction of trastuzumab, a monoclonal antibody against the her2 receptor, which, in combination with chemotherapy, significantly improves survival in both metastatic and early disease. Although the efficacy of biologics is undeniable, their expense is a significant contributor to the increasing cost of cancer care...
June 2018: Current Oncology
https://www.readbyqxmd.com/read/29910656/hormone-receptor-positive-her2-negative-metastatic-breast-cancer-redrawing-the-lines
#20
REVIEW
A Matutino, A A Joy, C Brezden-Masley, S Chia, S Verma
Estrogen receptor modulators and estrogen deprivation have become standards of care for hormone receptor-positive metastatic breast cancer. However, after traditional first-line endocrine monotherapy treatment, the disease typically progresses despite the initial high rate of clinical benefit. Multiple studies have aimed at optimizing treatment strategies to improve upon clinical benefit beyond the traditional single-agent endocrine treatment. With the availability of new data and novel therapies, the clinical practice challenge becomes how best to define the optimal treatment sequence to maximize clinical benefit...
June 2018: Current Oncology
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