Tommaso Dionisi, Giovanna Di Sario, Lorenzo De Mori, Giorgia Spagnolo, Mariangela Antonelli, Claudia Tarli, Luisa Sestito, Francesco Antonio Mancarella, Daniele Ferrarese, Antonio Mirijello, Gabriele Angelo Vassallo, Antonio Gasbarrini, Giovanni Addolorato
Emerging treatments for alcohol dependence reveal an intricate interplay of neurobiological, psychological, and circumstantial factors that contribute to Alcohol Use Disorder (AUD). The approved strategies balancing these factors involve extensive manipulations of neurotransmitter systems such as GABA, Glutamate, Dopamine, Serotonin, and Acetylcholine. Innovative developments are engaging mechanisms such as GABA reuptake inhibition and allosteric modulation. Closer scrutiny is placed on the role of Glutamate in chronic alcohol consumption, with treatments like NMDA receptor antagonists and antiglutamatergic medications showing significant promise...
2024: International Review of Neurobiology