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https://www.readbyqxmd.com/read/29776362/apolipoprotein-b-apolipoprotein-a1-ratio-and-mortality-among-incident-peritoneal-dialysis-patients
#1
Xiaojiang Zhan, Yanbing Chen, Caixia Yan, Siyi Liu, Lijuan Deng, Yuting Yang, Panlin Qiu, Dan Pan, Bingxiang Zeng, Qinkai Chen
BACKGROUND: To investigate the association between the ratio of apolipoprotein B (apo B) / apolipoprotein A1 (apo A1) with all-cause mortality and cardiovascular events in peritoneal dialysis (PD) patients. METHODS: Eight hundred and sixty incident PD patients were enrolled from November 1, 2005, to February 28, 2017, and followed until May 31, 2017. Outcomes were all-cause mortality and cardiovascular events. Associations between the apo B/apo A1 ratio with all-cause mortality and cardiovascular events were evaluated using multivariable-adjusted Cox models...
May 17, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29773952/remote-ischemic-preconditioning-in-myocardial-protection-in-hemodialysis-patients
#2
Marcelo R Bacci, Livia Y Vasconcelos, Neif Murad, Antonio Carlos P Chagas, Ana Carolina Capuano, Beatriz Ca Alves, Edimar C Pereira, Ligia A Azzalis, Virginia Bc Junqueira, Fernando LA Fonseca
Background: Remote ischemic preconditioning (RIPC) is a procedure that generates a brief period of ischemia followed by reperfusion. The role of RIPC in protecting myocardial ischemia during hemodialysis is not yet established. The aim of the study was to evaluate RIPC myocardial protection as evaluated by ultrasensitive I troponin in hemodialysis outpatients. Patients and methods: A double-blind randomized trial with two groups: intervention submitted to RIPC and control group without RIPC...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/29761502/efficacy-of-tunnel-technique-in-the-treatment-of-localized-and-multiple-gingival-recessions-a-systematic-review-and-a-meta-analysis
#3
REVIEW
Lorenzo Tavelli, Shayan Barootchi, Trang V N Nguyen, Mustafa Tattan, Andrea Ravidà, Hom-Lay Wang
BACKGROUND: Tunnel technique (TUN) has recently gained popularity among clinicians for its promising clinical and esthetic results when treating gingival recessions (GRs) defects. However, the evidence of the efficacy of TUN in the literature is still to be determined. Therefore, the aim of the present systematic review and meta-analysis was to investigate the predictability of TUN and its comparison to coronally advanced flap (CAF) procedure. MATERIAL AND METHODS: A literature search on PubMed, Cochrane libraries, EMBASE, and hand-searched journals until November 2017 was conducted to identify clinical studies investigating TUN for root coverage procedures...
May 14, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29751781/full-normalization-of-severe-hypertension-after-parathryoidectomy-a-case-report-and-systematic-review
#4
Andreea Corina Sofronie, Isabelle Kooij, Claude Bursot, Giulia Santagati, Jean-Philippe Coindre, Giorgina Barbara Piccoli
BACKGROUND: Although the relationship between hyperparathyroidism and hypertension has been described for decades, the role of hyperparathyroidism in hypertension in dialysis is still unclear. Following the case of a severely hypertensive dialysis patient, in which parathyroidectomy (PTX) corrected the metabolic imbalance and normalized blood pressure (BP), we tried to contextualize our observation with a systematic review of the recent literature on the effect of PTX on BP. CASE PRESENTATION: A dialysis patient, aged 19 years at the time of this report, with chronic kidney disease (CKD) from childhood; he was an early-preterm baby with very low birth weight (910 g), and is affected by a so-far unidentified familial nephropathy...
May 11, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29731065/vdj-gene-usage-of-b-cell-receptors-in-peripheral-blood-of-abo-incompatible-kidney-transplantation-patients
#5
H J Jeon, T Fang, J-G Lee, J Y Jang, K Kim, S Choi, J-J Yan, J H Ryu, T Y Koo, C Ahn, J Yang
INTRODUCTION: B cell subtypes and immunoglobulin variable (V), diversity (D), joining (J) gene segment usage of B cell receptors in ABO-incompatible (ABOi) kidney transplantation (KT) in comparison to ABO-compatible KT have not been studied. The aims of this study were to analyze the VDJ gene segment usages of B cell receptors in peripheral blood of ABOi KT recipients. METHODS: Eighteen ABOi KT patients with accommodation (ABOiA), 10 ABO-compatible stable KT patients (ABOcS), and 10 ABOi KT patients with biopsy-proven acute antibody-mediated rejection (ABOiR) at day 10 after transplantation were selected...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29720823/-in-vitro-induction-and-generation-of-tetraploid-plants-of-sophora-tonkinensis-gapnep
#6
Kun Hua Wei, Jian Ping Xu, Lin Xuan Li, Jin Yuan Cai, Jian Hua Miao, Min Hui Li
Background: Sophora tonkinensis Gapnep. is an important medical plant in China. Early researches of S. tonkinensis were focused on rapid propagation and quality analysis of in vitro tissue culture plantlet, and still no research focuses on the plant breeding of and there were no excellent varieties for artificial cultivation of S. tonkinensis . Objective: To set up a method to generate and select the best varieties of S. tonkinensis by polyploid breeding after induction by colchicine treatment...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29714440/the-impact-of-visit-to-visit-systolic-blood-pressure-variability-on-residual-renal-function-and-left-ventricular-hypertrophy-in-peritoneal-dialysis-patients
#7
Jun-Ping Tian, Hong Wang, Xin-Kui Tian, Feng-He Du, Tao Wang
Background/aim: Blood pressure (BP) variability is more closely associated with adverse outcomes than ‘usual’ BP in the general population. Residual renal function (RRF) and left ventricular hypertrophy (LVH) are thought to be predictors of poor outcome in dialysis patients. However, only a few studies have focused on BP variation and its link to RRF, LVH, and outcome in peritoneal dialysis (PD) patients. Therefore, we aimed to explore the effect of visit-to-visit BP variability on RRF and LVH in continuous ambulatory PD (CAPD) patients...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29701909/the-impact-of-direct-acting-antiviral-agents-on-liver-and-kidney-transplant-costs-and-outcomes
#8
D A Axelrod, M A Schnitzler, T Alhamad, F Gordon, R D Bloom, G P Hess, H Xiao, M Nazzal, D L Segev, V R Dharnidharka, A S Naik, N N Lam, R Ouseph, B L Kasiske, C Durand, K L Lentine
Direct-acting antiviral medications (DAAs) have revolutionized care for hepatitis C positive (HCV+) liver (LT) and kidney (KT) transplant recipients. SRTR registry data were integrated with national pharmaceutical claims (2007-2016) to identify HCV treatments before 1/2014 (pre-DAA) and after (post-DAA), stratified by donor (D) and recipient (R) serostatus and payer. Pre-DAA, 18% of HCV+ LT recipients were treated within 3 years and without differences by donor serostatus or payer. Post-DAA, only 6% of D-/R+ recipients, 19...
April 27, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29694950/is-sclerostin-level-associated-with-cardiovascular-diseases-in-hemodialysis-patients
#9
Gokce Kundakci Gelir, Sule Sengul, Gokhan Nergizoglu, Sehsuvar Ertürk, Neval Duman, Sim Kutlay
BACKGROUND/AIMS: The objective of this study is to evaluate the relation between sclerostin, arterial stiffness, and cardiovascular events (CVE) in hemodialysis patients (HD). METHODS: Sclerostin level and carotid-femoral pulse wave velocity (PWV) in 97 HD patients and sclerostin level in 40 controls were measured. RESULTS: Sclerostin level was significantly higher in patients than in controls. Sclerostin associated positively with age, male gender, cardiovascular disease, statin use, BMI, and PWV while negatively with alkaline phosphatase, parathormone (PTH), Kt/V, cinacalcet and vitamin D use in univariable correlation analyses...
April 25, 2018: Blood Purification
https://www.readbyqxmd.com/read/29689346/b-type-natriuretic-peptide-attenuates-endoplasmic-reticulum-stress-in-h9c2-cardiomyocytes-underwent-hypoxia-reoxygenation-injury-under-high-glucose-high-fat-conditions
#10
Pan Chang, Mingyang Zhang, Xiaomeng Zhang, Guohua Li, Haiyan Hu, Juan Wu, Xihui Wang, Zihua Yang, Jing Zhang, Weiguo Chen, Minggang Ren, Xin Li, Miaozhang Zhu, Baoying Chen, Jun Yu
Exogenously administered B-type natriuretic peptide (BNP) has been shown to provide cardioprotection against various heart diseases. However, the underlying mechanisms remain elusive. This study explores whether BNP exerts its cardioprotection against hypoxia/reoxygenation (H/R) injury under high glucose/high fat (HG/HF) conditions in cardiac H9c2 cells and uncovers the underlying mechanisms. Our data revealed that BNP significantly increased the cell viability and decreased the release of lactate dehydrogenase (LDH) and creatine kinase (CK), with a maximal effect at the BNP concentration of 10-7  mol/L...
April 21, 2018: Peptides
https://www.readbyqxmd.com/read/29688442/impact-of-residual-kidney-function-on-hemodialysis-adequacy-and-patient-survival
#11
Mengjing Wang, Yoshitsugu Obi, Elani Streja, Connie M Rhee, Jing Chen, Chuanming Hao, Csaba P Kovesdy, Kamyar Kalantar-Zadeh
Background: Both dialysis dose and residual kidney function (RKF) contribute to solute clearance and are associated with outcomes in hemodialysis patients. We hypothesized that the association between dialysis dose and mortality is attenuated with greater RKF. Methods: Among 32 251 incident hemodialysis patients in a large US dialysis organization (2007-11), we examined the interaction between single-pool Kt/V (spKt/V) and renal urea clearance (rCLurea) levels in survival analyses using multivariable Cox proportional hazards regression model...
April 23, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29684176/age-and-weight-based-differences-in-haemodialysis-prescription-and-delivery-in-children-adolescents-and-young-adults
#12
Verena Gotta, Olivera Marsenic, Marc Pfister
Background: Limited systematic data are available on prescription and dosing of haemodialysis (HD) in children and adolescents compared with adults. We aimed to characterize age- and weight-based differences in HD delivery in children, adolescents and young adults. Methods: This is a retrospective observational study including 1852 patients <30 years on chronic HD from childhood (53 903 HD sessions), receiving thrice weekly outpatient HD between 2004 and 2016 in the USA (6075 patient-years, of which 2535 were in patients aged 1-18 years; weight range 8...
April 18, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29674265/relationship-between-plasma-levels-of-homocysteine-and-the-related-b-vitamins-in-patients-with-hemodialysis-adequacy-or-inadequacy
#13
En-Ling Yeh, Yi-Chia Huang, Shang-Feng Tsai, Tong-Min Yu, Ming-Ju Wu, Cheng-Hsu Chen
OBJECTIVES: Hemodialysis (HD) with dialysis adequacy could increase the excretion of B vitamins (folate, vitamin B6 , and B12 ) and raise the plasma level of homocysteine. Here we determined the associations of plasma homocysteine with B vitamins in patients with HD adequacy or inadequacy. METHODS: We recruited 68 patients who had received HD treatments (three times a week, 4 h each). Based on the individual's hemogram and quarterly urea reduction rate (Kt/V), patients were pooled into one of the following two groups: the first group with dialysis adequacy (Kt/V > 1...
February 14, 2018: Nutrition
https://www.readbyqxmd.com/read/29663430/effectiveness-of-a-new-single-needle-single-pump-dialysis-system-with-simultaneous-monitoring-of-dialysis-dose
#14
Wolfgang Bieser, Markus Welsch, Marten Jakob, Jörn Meibaum, David A Rodriguez, Henrik Wolff, Daniele Marcelli, Claudia Barth
To date, single-needle (SN) hemodialysis (HD) requires a dialysis machine equipped with two blood pumps-one controlling arterial blood flow (Qb) and one controlling venous Qb. B. Braun has developed an innovative single-pump SN HD system. Therefore, usability is improved by reducing complexity. The aim of this study was to compare dialysis parameters of the new single-pump SN HD system with a double-pump SN HD system available on the market (Fresenius Medical Care [FMC] 5008). In this two-armed crossover study, patients were randomized into two groups (B...
April 16, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29642725/comparison-of-methods-to-estimate-haemodialysis-urea-clearance
#15
Ahmed Mohamed, Andrew Davenport
INTRODUCTION: Dialysis adequacy is traditionally measured by monthly blood urea sampling and calculating sessional Kt/Vurea. Modern dialysis machines can estimate clearances each session, so we wished to compare online measurements with standard Kt/Vurea. METHODS: Urea clearance was estimated by intermittent changes in effective ionic dialysance and by continuous ultraviolet light absorption spent during the mid-week dialysis session. Total body water was calculated by the Watson equation and measured by multifrequency bioimpedance...
April 1, 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29606268/-incremental-haemodialysis
#16
Cécile Courivaud
The majority of incidental haemodialysis patients are systematically treated at the rate of three sessions per week, regardless of their level of residual kidney function. Incremental haemodialysis is a therapeutic strategy adapted to the residual kidney function level of each patient, to offer patients only the "dialysis dose" needed to supplement their residual kidney function, while ensuring that they achieve the objective of total clearance (renal+per-HD) recommended (weekly Standard Kt/V urea>2...
April 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29578936/mathematical-representation-of-standard-kt-v-including-ultrafiltration-and-residual-renal-function
#17
Jan Sternby
A new formula for calculating standard Kt/V from clinical data has been derived mathematically. It is based on using the relation between eKt/V and the pre- and postdialysis concentrations in order to find the steady state concentrations. The resulting expression for standard Kt/V depends on the treatment schedule (number, length, and spacing of treatments), residual renal function, and eKt/V and relative ultrafiltration volume of each individual treatment. These results include the effects of ultrafiltration and residual renal function also in the case with unequal treatments that may be arbitrarily distributed over the week...
March 23, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29573025/should-we-look-beyond-kt-v-urea-in-assessing-dialysis-adequacy
#18
Clare B Jones, Joanne M Bargman
Since the advent of maintenance dialysis therapy, our interpretation of what adequate dialysis really is has broadened and become more controversial. This is not only due to our changing and aging dialysis population but also to our evolving knowledge base. As nephrologists, we strive to achieve both quality and (often) quantity of life for our patients and we feel reassured when we have a quantifiable marker to show for our efforts. However, we suggest that adequate dialysis reaches far beyond the realms of attaining a particular biochemical result...
March 23, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/29566211/is-kt-v-useful-in-elderly-dialysis-patients-pro-and-con-arguments
#19
James Tattersall, Ken Farrington, Giorgio Gentile, Jeroen Kooman, Juan F Macias Núñez, Ionut Nistor, Wim Van Biesen, Adrian Covic
Current guidelines for dialysis specify a minimum Kt/V. For haemodialysis (HD) patients, minimum treatment time and frequency is also specified. The guidelines allow for modification to take account of renal function. The guidelines are not specifically aimed at the elderly and may not be appropriate for all patients in this group. Increasing age is accompanied by physiological and pathological changes that may modify the patient's response to uraemia and dialysis. Frailty and multi-morbidity are likely, but to a variable extent...
May 1, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29560929/isotope-specific-breath-analysis-to-track-the-end-stage-renal-disease-during-hemodialysis
#20
Santanu Mandal, Prabuddha Mukhopadhyay, Chiranjit Ghosh, Mithun Pal, Gourab Dutta Banik, Tanmoy Chatterjee, Shibendu Ghosh, Manik Pradhan
The underlying mechanisms towards the progression of end-stage renal disease (ESRD) in chronic kidney disease (CKD) are poorly understood and it still remains a major clinical stumbling block for early detection of CKD. Most patients with CKD pass through ESRD with the necessity of frequent hemodialysis (HD) treatment. At present, plasma urea and creatinine levels are examined in most of the CKD patients to monitor the patients' health status after dialysis. But it is really impossible to get immediate feedback of the patients' health as the conventional tests are involved with the collection of blood samples, laboratory processing for prolong time and finally analysis of those samples...
March 21, 2018: Journal of Breath Research
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