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https://www.readbyqxmd.com/read/29625583/structural-and-mechanistic-aspects-influencing-the-adam10-mediated-shedding-of-the-prion-protein
#1
Luise Linsenmeier, Behnam Mohammadi, Sebastian Wetzel, Berta Puig, Walker S Jackson, Alexander Hartmann, Keiji Uchiyama, Suehiro Sakaguchi, Kristina Endres, Jörg Tatzelt, Paul Saftig, Markus Glatzel, Hermann C Altmeppen
No abstract text is available yet for this article.
April 6, 2018: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/29615891/catalpol-inhibits-amyloid-%C3%AE-generation-through-promoting-%C3%AE-cleavage-of-app-in-swedish-mutant-app-overexpressed-n2a-cells
#2
Zhuo Wang, Xueshi Huang, Pu Zhao, Limei Zhao, Zhan-You Wang
Amyloid-β (Aβ) peptides play a crucial role in the pathogenesis of Alzheimer's disease (AD), due to its neurotoxicity. Thus, blocking Aβ generation and aggregation in the brain has been realized as an efficient way for the prevention of AD. The natural product catalpol, isolated from Rehmannia glutinosa , has shown neuroprotective activities through inhibiting soluble Aβ production, degrading Aβ peptide, and attenuating Aβ toxicity and neuroinflammatory responses. In the present study, we aimed to evaluate whether catalpol reduce Aβ generation associated with regulating amyloid precursor protein (APP) proteolytic processing...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29611102/11%C3%AE-hsd1-inhibition-by-rl-118-promotes-autophagy-and-correlates-with-reduced-oxidative-stress-and-inflammation-enhancing-cognitive-performance-in-samp8-mouse-model
#3
Dolors Puigoriol-Illamola, Christian Griñán-Ferré, Foteini Vasilopoulou, Rosana Leiva, Santiago Vázquez, Mercè Pallàs
Elevated glucocorticoid (GC) exposure is widely accepted as a key factor in the age-related cognitive decline in rodents and humans. 11β-HSD1 is a key enzyme in the GCs pathway, catalyzing the conversion of 11β-dehydrocorticosterone to corticosterone in mice, with possible implications in neurodegenerative processes and cognitive impairment. Here, we determined the effect of a new 11β-HSD1 inhibitor, RL-118, administered to 12-month-old senescence-accelerated mouse-prone 8 (SAMP8) mice with neuropathological AD-like hallmarks and widely used as a rodent model of cognitive dysfunction...
April 2, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29604594/lncrna-snhg20-promotes-cell-proliferation-and-invasion-via-mir-140-5p-adam10-axis-in-cervical-cancer
#4
Huimin Guo, Shenghua Yang, Shaoru Li, Mengting Yan, Li Li, Hongxia Zhang
BACKGROUND: Recent studies highlight the crucial regulatory roles of long non-coding RNAs (lncRNAs) in carcinogenesis. However, involvement of the lncRNA SNHG20 in cervical cancer progression remains unclear. METHODS: The expression of SNHG20 and miR-140-5p was determined in cervical cancer. Gain or loss of function assays were used to explore the roles of SNHG20 and miR-140-5p in cervical cancer cells. Luciferase assay and Western blot were used to explore the underlying mechanisms of SNHG20 and miR-140-5p in cervical cancer progression...
March 28, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29595456/-improvement-and-the-mechanism-of-cardiac-function-by-knockdown-of-adam10-in-adriamycin-induced-cardiomyopathy-rats
#5
Xiaoou Li, Lili Xie, Bing He, Wei Huang
Objective To study the role of a disintegrin and metalloproteinase10 (ADAM10) in shedding neural cadherin (N-cadherin) and develop an approach to interfere the process of ventricular remodeling in adriamycin-induced cardiomyopathy (ACM) rats. Methods In a rat model of ACM, the effects of intraperitoneal injection of the lentiviral RNAi vector of ADAM10 on the morphology of cardiomyocytes and contractile function were observed by HE staining and color Doppler echocardiography. The expressions of N-cadherin and C-terminal fragment 1 (CTF1) were detected by Western blotting and immunohistochemistry...
January 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29533934/two-n-linked-glycans-differentially-control-maturation-trafficking-and-proteolysis-but-not-activity-of-the-il-11-receptor
#6
Maria Agthe, Yvonne Garbers, Joachim Grötzinger, Christoph Garbers
BACKGROUND/AIMS: The cytokine interleukin-11 (IL-11) has important pro- and anti-inflammatory functions. It activates its target cells through binding to the IL-11 receptor (IL-11R), and the IL-11/IL-11R complex recruits a homodimer of glycoprotein 130 (gp130). N-linked glycosylation, a post-translational modification where complex oligosaccharides are attached to the side chain of asparagine residues, is often important for stability, folding and biological function of cytokine receptors...
March 7, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29520422/in-vivo-regulation-of-the-a-disintegrin-and-metalloproteinase-10-adam10-by-the-tetraspanin-15
#7
Lisa Seipold, Hermann Altmeppen, Tomas Koudelka, Andreas Tholey, Petr Kasparek, Radislav Sedlacek, Michaela Schweizer, Julia Bär, Marina Mikhaylova, Markus Glatzel, Paul Saftig
A disintegrin and metalloproteinase 10 (ADAM10) plays a major role in the ectodomain shedding of important surface molecules with physiological and pathological relevance including the amyloid precursor protein (APP), the cellular prion protein, and different cadherins. Despite its therapeutic potential, there is still a considerable lack of knowledge how this protease is regulated. We have previously identified tetraspanin15 (Tspan15) as a member of the TspanC8 family to specifically associate with ADAM10...
March 8, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29519253/the-glycoprotein-gpnmb-attenuates-astrocyte-inflammatory-responses-through-the-cd44-receptor
#8
Matthew L Neal, Alexa M Boyle, Kevin M Budge, Fayez F Safadi, Jason R Richardson
BACKGROUND: Neuroinflammation is one of the hallmarks of neurodegenerative diseases, such as Parkinson's disease (PD). Activation of glial cells, including microglia and astrocytes, is a characteristic of the inflammatory response. Glycoprotein non-metastatic melanoma protein B (GPNMB) is a transmembrane glycoprotein that releases a soluble signaling peptide when cleaved by ADAM10 or other extracellular proteases. GPNMB has demonstrated a neuroprotective role in animal models of ALS and ischemia...
March 8, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29484441/a-disintegrin-and-metalloprotease-10-containing-exosomes-derived-from-nasal-polyps-promote-angiogenesis-and-vascular-permeability
#9
Wei Zhang, Jie Zhang, Lei Cheng, Haosheng Ni, Bo You, Ying Shan, Lili Bao, Di Wu, Ting Zhang, Huijun Yue, Jing Chen
Abnormal angiogenesis and vascular permeability is important for the formation of nasal polyps (NPs). Increasing evidence has indicated that exosomes serve a vital role in modulating angiogenesis and vascular permeability. A disintegrin and metalloprotease 10 (ADAM10), an important type of proteinase that is overexpressed in various diseases, can influence angiogenesis and vascular permeability and has been observed in healthy nasal exosomes. To the best of our knowledge, the expression levels and the function of ADAM10 in NLF‑derived exosomes from NPs has not been demonstrated previously...
February 26, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29464750/inhibition-of-adam10-in-satellite-cells-accelerates-muscle-regeneration-following-muscle-injury
#10
Sakiko Mizuno, Masaki Yoda, Masayuki Shimoda, Kazuhiro Chiba, Masaya Nakamura, Keisuke Horiuchi
Muscle injury is one of the most common orthopedic and sports disorders. For severe cases, surgical repair may be indicated; however, other than immobilization and the administration of anti-inflammatory drugs there is currently no effective conservative treatment for this condition. Satellite cells (SCs) are muscle-specific stem cells and are indispensable for muscle regeneration after muscle injury. SCs are activated upon muscle injury to proliferate and differentiate into myoblasts, which subsequently fuse into myofibers and regenerate the damaged muscle...
February 21, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29459438/non-cell-autonomous-function-of-dr6-in-schwann-cell-proliferation
#11
Alessio Colombo, Hung-En Hsia, Mengzhe Wang, Peer-Hendrik Kuhn, Monika S Brill, Paolo Canevazzi, Regina Feederle, Carla Taveggia, Thomas Misgeld, Stefan F Lichtenthaler
Death receptor 6 (DR6) is an orphan member of the TNF receptor superfamily and controls cell death and differentiation in a cell-autonomous manner in different cell types. Here, we report an additional non-cell-autonomous function for DR6 in the peripheral nervous system (PNS). DR6-knockout (DR6 KO) mice showed precocious myelination in the PNS Using an in vitro myelination assay, we demonstrate that neuronal DR6 acts in trans on Schwann cells (SCs) and reduces SC proliferation and myelination independently of its cytoplasmic death domain...
February 19, 2018: EMBO Journal
https://www.readbyqxmd.com/read/29454265/supplementation-of-lycopene-attenuates-lipopolysaccharide-induced-amyloidogenesis-and-cognitive-impairments-via-mediating-neuroinflammation-and-oxidative-stress
#12
Jia Wang, Lixia Li, Zhuo Wang, Yifan Cui, Xintong Tan, Tian Yuan, Qian Liu, Zhigang Liu, Xuebo Liu
Neuroinflammation is documented to be the major culprit of Alzheimer's disease. Lycopene (LYC), a fat soluble carotenoid, exhibits neuroprotective function in several neurodegenerative disorders. However, the effects of LYC to countering systemic inflammation-induced amyloidogenesis and memory deficiency remain to be elucidated. In current study, 3-month-old male C57BL/6J mice were treated with 0.03% LYC (w/w, mixed into normal chow) for 5 weeks. The mice were then treated by intraperitoneal injection of LPS (0...
February 2, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29449775/prion-proteins-without-the-glycophosphatidylinositol-anchor-potential-biomarkers-in-neurodegenerative-diseases
#13
REVIEW
Valerija Kovač, Vladka Čurin Šerbec
Prion protein (PrP) is a biomolecule that is involved in neuronal signaling, myelinization, and the development of neurodegenerative diseases. In the cell, PrP is shed by the ADAM10 protease. This process generates PrP molecules that lack glycophosphatidylinositol anchor, and these molecules incorporate into toxic aggregates and neutralize toxic oligomers. Due to this dual role, these molecules are important biomarkers for neurodegenerative diseases. In this review, we present shed PrP as a potential biomarker, with a focus on PrP226*, which may be the main biomarker for predicting neurodegenerative diseases in humans...
2018: Biomarker Insights
https://www.readbyqxmd.com/read/29437707/proteolytic-release-of-the-p75ntr-intracellular-domain-by-adam10-promotes-metastasis-and-resistance-to-anoikis
#14
Xin Bao, Jianbo Shi, Furong Xie, Zengying Liu, Jingshuang Yu, Wan-Tao Chen, Zhiyuan Zhang, Qin Xu
Resistance to anoikis allows cancer cells to survive during systemic circulation, however, the mechanism underlying anoikis resistance remains unclear. Here we show that A disintegrin and metalloprotease 10 (ADAM10)-mediated cleavage of p75 neurotrophin receptor (p75NTR) and subsequent generation of the p75NTR intracellular domain (ICD) endows cancer cells with resistance to anoikis. p75NTR ICD promoted expression of TNF receptor associated factor 6 (TRAF6), a critical intermediary in p75NTR ICD-mediated signal transduction, at the translational level...
February 6, 2018: Cancer Research
https://www.readbyqxmd.com/read/29434796/adam-proteases-involved-in-inflammation-are-differentially-altered-in-patients-with-gastritis-or-ulcer
#15
Nuray Erin, Sema Türker, Özlem Elpek, Bülent Yildirim
ADAM metallopeptidase domain (ADAM)9, 10 and 17 have α-secretase activity that regulates ectodomain shedding of factors involved in inflammation, cell proliferation, angiogenesis, and wound healing. The secretase activity of ADAM proteins is known to induce an inflammatory response. However, under certain conditions, a lack of secretase activity may induce inflammation suggesting differential roles of ADAM proteins with secretase activity. To the best of our knowledge, the present study evaluated the changes in α-secretase activity and expression of associated ADAM proteases (ADAM9, 10 and 17) in the gastric mucosa of patients with gastritis and ulcers, for the first time...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29430990/the-metalloprotease-adam10-a-disintegrin-and-metalloprotease-10-undergoes-rapid-postlysis-autocatalytic-degradation
#16
Tobias Brummer, Martina Pigoni, Armando Rossello, Huanhuan Wang, Peter J Noy, Michael G Tomlinson, Carl P Blobel, Stefan F Lichtenthaler
The transmembrane protein, ADAM10 (a disintegrin and metalloprotease 10), has key physiologic functions-for example, during embryonic development and in the brain. During transit through the secretory pathway, immature ADAM10 (proADAM10) is converted into its proteolytically active, mature form (mADAM10). Increasing or decreasing the abundance and/or activity of mADAM10 is considered to be a therapeutic approach for the treatment of such diseases as Alzheimer's disease and cancer. Yet biochemical detection and characterization of mADAM10 has been difficult...
February 7, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29416721/collagen-xvii-laminin-5-activates-epithelial-to-mesenchymal-transition-and-is-associated-with-poor-prognosis-in-lung-cancer
#17
Chen-Chi Liu, Jiun-Han Lin, Tien-Wei Hsu, Jyuan-Wei Hsu, Jer-Wei Chang, Kelly Su, Han-Shui Hsu, Shih-Chieh Hung
Epithelial-to-mesenchymal transition (EMT) is associated with tumor metastasis and tumorigenesis in lung cancer stem-like cells (CSCs). However, the exact mechanism underlying this is not clear. We used microarray analysis to identify candidate genes responsible for EMT in spheroid and monolayer cultures of lung cancer cells. We found increased expression of a variety of adhesion molecules in CSCs. One of these molecules, Collagen XVII (Col XVII), was demonstrated to be required for maintenance of EMT phenotypes and metastasis ability in lung CSCs...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29397483/glomerular-endothelial-cell-maturation-depends-on-adam10-a-key-regulator-of-notch-signaling
#18
Gregory Farber, Romulo Hurtado, Sarah Loh, Sébastien Monette, James Mtui, Raphael Kopan, Susan Quaggin, Catherine Meyer-Schwesinger, Doris Herzlinger, Rizaldy P Scott, Carl P Blobel
The principal function of glomeruli is to filter blood through a highly specialized filtration barrier consisting of a fenestrated endothelium, the glomerular basement membrane and podocyte foot processes. Previous studies have uncovered a crucial role of endothelial a disintegrin and metalloprotease 10 (ADAM10) and Notch signaling in the development of glomeruli, yet the resulting defects have not been further characterized nor understood in the context of kidney development. Here, we used several different experimental approaches to analyze the kidneys and glomeruli from mice lacking ADAM10 in endothelial cells (A10ΔEC mice)...
February 3, 2018: Angiogenesis
https://www.readbyqxmd.com/read/29382156/alpha-secretase-adam10-regulation-insights-into-alzheimer-s-disease-treatment
#19
REVIEW
Rafaela Peron, Izabela Pereira Vatanabe, Patricia Regina Manzine, Antoni Camins, Márcia Regina Cominetti
ADAM (a disintegrin and metalloproteinase) is a family of widely expressed, transmembrane and secreted proteins of approximately 750 amino acids in length with functions in cell adhesion and proteolytic processing of the ectodomains of diverse cell-surface receptors and signaling molecules. ADAM10 is the main α-secretase that cleaves APP (amyloid precursor protein) in the non-amyloidogenic pathway inhibiting the formation of β-amyloid peptide, whose accumulation and aggregation leads to neuronal degeneration in Alzheimer's disease (AD)...
January 29, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29359863/dose-and-timing-of-n-cadherin-mimetic-peptides-regulate-msc-chondrogenesis-within-hydrogels
#20
Mi Y Kwon, Sebastián L Vega, William M Gramlich, Minwook Kim, Robert L Mauck, Jason A Burdick
The transmembrane glycoprotein N-cadherin (NCad) mediates cell-cell interactions found during mesenchymal condensation and chondrogenesis. Here, NCad-derived peptides (i.e., HAV) are incorporated into hyaluronic acid (HA) hydrogels with encapsulated mesenchymal stem cells (MSCs). Since the dose and timing of NCad signaling are dynamic, HAV peptide presentation is tuned via alterations in peptide concentration and incorporation of an ADAM10-cleavable domain between the hydrogel and the HAV motif, respectively...
January 23, 2018: Advanced Healthcare Materials
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