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Cutaneous lymphoma

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https://www.readbyqxmd.com/read/29332711/very-low-dose-versus-standard-dose-radiation-therapy-for-indolent-primary-cutaneous-b-cell-lymphomas-a-retrospective-study
#1
Amrita Goyal, Joi B Carter, Itai Pashtan, Sara Gallotto, Irene Wang, Scott Isom, Andrea Ng, Karen M Winkfield
No abstract text is available yet for this article.
February 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29332707/cutaneous-hemophagocytosis-clinicopathologic-features-of-21-cases
#2
Francesca Boggio, Viviana Lora, Carlo Cota, Amanda Pereira, Robert Müllegger, Lucia Prieto-Torres, Lorenzo Cerroni
BACKGROUND: Hemophagocytosis is well known in cytotoxic cutaneous T-cell lymphomas (CTCLs), in which it may represent a sign of hemophagocytic lymphohistiocytosis syndrome (HLHS), and is also typical of cutaneous Rosai-Dorfman disease (cRDD) (without prognostic relevance). Only rarely, has cutaneous hemophagocytosis (CH) been described in other skin conditions. OBJECTIVE: To characterize the clinicopathologic features of CH in skin biopsy specimens from patients with conditions other than CTCL or cRDD...
February 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29330308/survival-outcomes-of-primary-cutaneous-t-cell-lymphoma-in-hiv-infected-patients-a-national-population-based-study
#3
Jianhong Wang, Rong Liang, Caixia Hao, Xiangxiang Liu, Na Zhang, Xiaohui Duan, Hongjuan Dong, Baoxia Dong, Hongtao Gu, Guangxun Gao, Tao Zhang, Qingxian Bai, Xiequn Chen
This study aimed to investigate clinical characteristics and survival outcomes of primary cutaneous T-cell lymphoma (CTCL) in HIV-infected and non-HIV-infected patients. All data were from the Surveillance, Epidemiology, and End Results program, 1973-2013, of the U.S. National Cancer Institute. Data of 318 HIV-infected patients and 1272 non-HIV-infected patients with primary CTCL were analyzed. Endpoints were overall survival and cancer-specific mortality. Independent variables included demographics, pre-existing malignancy, treatments, and environmental factors...
January 12, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29327700/disseminated-cutaneous-fusariosis-in-human-immunodeficiency-virus-infected-patient-and-dramatic-response-with-oral-itraconazole
#4
Indu Kumari, Satyendra Kumar Singh, Rishabh Kumar Chauhan, Satyendra Kumar Kaushal
Fusarium species are known to cause disseminated cutaneous lesions in immunocompromised patients. Some cases of fusariosis are reported in patients infected with the human immunodeficiency virus. There are two reports in such patients with systemic comorbidities like lymphoma, neutropenia and infective port-a-catheter. Another reported patient had systemic fusariosis, without skin involvement. Diagnosis and treatment of cutaneous fusariosis is difficult and resistance to antifungals is a problem. Our patient was at an advanced human immunodeficiency virus infection stage with disseminated cutaneous fusariosis, without any systemic involvement, who responded completely to oral itraconazole...
January 9, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29327534/gastric-angioinvasive-mucormycosis-in-immunocompetent-adult-a-rare-occurrence
#5
Mukesh Nasa, Zubin Sharma, Lipika Lipi, Randhir Sud
Mucormycosis is a rare, opportunistic fungal infection that occurs almost exclusively in immunocompromised hosts such as patients with diabetes mellitus, leukemia, lymphoma, renal disease, septicemia, burns, malnutrition, and following long-term treatment with steroids and antibiotics. Based on the clinical presentation and involvement, mucormycosis is classified as six major forms, namely, rhinocerebral, pulmonary, cutaneous, gastrointestinal (GI), disseminated and miscellaneous, with rhinocerebral and pulmonary being the common forms...
December 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29321428/synchronous-occurrence-of-mycosis-fungoides-diffuse-large-b-cell-lymphoma-and-acute-myeloid-leukemia-a-report-of-two-cases
#6
Junichi Miyatake, Hiroaki Inoue, Kentarou Serizawa, Yasuyoshi Morita, J L Espinoza, Hirokazu Tanaka, Takahiro Shimada, Yoichi Tatsumi, Takashi Ashida, Itaru Matsumura
Patients with mycosis fungoides (MF), the most common subtype of primary cutaneous T-cell lymphoma, have an increased risk of developing secondary malignancies. We herein report two rare cases of MF concurring with diffuse large B cell lymphoma (B lymphoid lineage) and acute myeloid leukemia (myeloid lineage) in two otherwise healthy elderly patients. Potential etiologic factors, including the impact of the therapy-associated inflammatory response on the development of secondary tumors in patients with MF, are discussed...
January 11, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29318693/4-6-4-trimethylangelicin-shows-high-anti-proliferative-activity-on-du145-cells-under-both-uva-and-blue-light
#7
G Miolo, G Sturaro, G Cigolini, L Menilli, A Tasso, I Zago, M T Conconi
OBJECTIVES: Furocoumarins (psoralens and angelicins) have been already used under ultraviolet A light (UVA) for the treatment of skin diseases and cutaneous T-cell lymphoma. Besides their high anti-proliferative activity, some severe long-term side effects have been observed, for example genotoxicity and mutagenicity, likely strictly related to the formation of crosslinks. It has been demonstrated that blue light (BL) activation of 8-methoxypsoralen, an FDA-approved drug, leads to less mutagenic monoadducts in the DNA...
January 10, 2018: Cell Proliferation
https://www.readbyqxmd.com/read/29318585/dermoscopic-characterization-of-cutaneous-lymphomas-a-pilot-survey
#8
Grant K Ghahramani, Kirsten E Goetz, Vincent Liu
BACKGROUND: While substantial dermoscopic analysis of melanocytic lesions has been performed, dermoscopic characterization of cutaneous lymphoid proliferations has been limited. Cutaneous lymphoma, particularly early mycosis fungoides (MF) and its variants, is often challenging to clinically and pathologically distinguish from inflammatory processes of the skin. This study aimed to survey the dermoscopic findings of cutaneous lymphomas and to discern whether any patterns might potentially serve as specific signatures...
January 10, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29316111/etoposide-as-a-single-agent-in-the-treatment-of-mycosis-fungoides-a-retrospective-analysis
#9
Seda Purnak, Jose Azar, Lawrence Aaron Mark
Several chemotherapy agents have shown efficacy in the treatment of mycosis fungoides (MF). In the literature, there is limited data on the use of single agent etoposide for MF. We aimed to retrospectively review our experience with single agent etoposide in the treatment of advanced-stage or refractory early-stage MF with focus on analyzing its efficacy and safety. We included 13 MF patients who were treated with single agent etoposide. Patients were identified through the Cutaneous T Cell Lymphoma Database of Indiana University that involves patients treated from 2006 to 2016...
January 9, 2018: Dermatologic Therapy
https://www.readbyqxmd.com/read/29315771/pityriasis-lichenoides-long-term-follow-up-study
#10
Julie B Zang, Sarah J Coates, Jing Huang, Eric C Vonderheid, Bernard A Cohen
BACKGROUND/OBJECTIVES: Pityriasis lichenoides is an uncommon papulosquamous disorder of unknown etiology. The objective of this study was to review the clinical features and treatment responses of individuals with pityriasis lichenoides seen at a tertiary referral center. METHODS: Seventy-five patients diagnosed with pityriasis lichenoides between 1997 and 2013 were reviewed, and 46 had long-term follow-up via telephone interviews. RESULTS: Fifty (67%) patients were diagnosed with pityriasis lichenoides chronica, 22 (29%) with pityriasis lichenoides et varioliformis acuta, and 3 (4%) with mixed pityriasis lichenoides chronica and pityriasis lichenoides et varioliformis acuta features...
January 9, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29313941/image-gallery-metachronic-occurrence-of-primary-cutaneous-marginal-zone-b-cell-lymphoma-and-primary-cutaneous-rosai-dorfman-disease-in-the-same-patient
#11
A González-Quesada, J Bastida, J C Rivero-Vera, M A Piris-Pinilla, M A Limeres-González
No abstract text is available yet for this article.
December 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29313932/brentuximab-vedotin-is-an-effective-therapy-for-cd30-mycosis-fungoides-and-cutaneous-anaplastic-large-cell-lymphoma-what-is-the-cost
#12
J J Scarisbrick
No abstract text is available yet for this article.
December 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29313927/image-gallery-primary-cutaneous-precursor-b-lymphoblastic-lymphoma-in-an-infant
#13
Y Luo, J Liu
No abstract text is available yet for this article.
December 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29308723/current-systemic-therapeutic-options-for-advanced-mycosis-fungoides-and-s%C3%A3-zary-syndrome
#14
Jenna Janiga, Jonathan Kentley, Chadi Nabhan, Farah Abdulla
Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common cutaneous T-cell lymphomas (CTCLs). Both lack curative options, and advanced-stage carries a poor prognosis. Whilst there are a number of treatments available, achieving and maintaining a durable remission remains challenging. We review current systemic treatment options as monotherapy for advanced-stage MF (IIB-IV), appraising their mechanism of action, analyzing their efficacy, and describing toxicities. Individually, reported overall response rates (ORR) vary widely in the literature and duration of responses are typically short, ranging from 7...
January 8, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29307643/progression-of-undiagnosed-cutaneous-lymphoma-after-anti-tumor-necrosis-factor-alpha-therapy
#15
Maria Estela Martinez-Escala, Alba L Posligua, Heather Wickless, Audrey Rutherford, Kimberly A Sable, Belen Rubio-Gonzalez, Xiaolong A Zhou, Jason B Kaplan, Barbara Pro, Jaehyuk Choi, Christiane Querfeld, Steven T Rosen, Joan Guitart
BACKGROUND: Cutaneous lymphoma (CL) diagnosed after anti-tumor necrosis factor (TNF)α therapy has been reported in the literature, yet a clear link between both events remains elusive. OBJECTIVE: To review our experience with CL diagnosed during or after the use of anti-TNFα therapies. METHODS: This is a multicenter retrospective study and a literature review. RESULTS: Twenty-two cases, including 20 cutaneous T-cell lymphomas (CTCL) and 2 cutaneous B-cell lymphomas (CBCL), were identified...
January 4, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29307600/pak1-overexpression-promotes-cell-proliferation-in-cutaneous-t-cell-lymphoma-via-suppression-of-puma-and-p21
#16
Yimeng Wang, Xiaoguang Gu, Weiwei Li, Qian Zhang, Chunlei Zhang
BACKGROUND: Cutaneous T cell lymphoma (CTCL) comprises a heterogeneous group of skin-homing T cell tumors. The small guanosine triphosphate effector p21-activated kinase 1 (PAK1) plays an important role in many fundamental cellular functions, including cell motility, proliferation, and apoptosis. The expression of PAK1 is up-regulated in several types of human cancers. However, little is known about the role of PAK1 in the pathogenesis of CTCL. OBJECTIVE: The aim of this study was to evaluate the expression pattern and underlying mechanism of PAK1 in CTCL...
January 4, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29306316/-cutaneous-lymphoma-associated-with-methotrexate-in-a-patient-with-rheumatoid-arthritis
#17
Vanesa Antón Vázquez, Héctor Corominas, Nadia García Muñoz, Gisela Hebe Petiti
No abstract text is available yet for this article.
January 1, 2018: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/29305299/identification-of-oaf-and-pvrl1-as-candidate-genes-for-an-ocular-anomaly-characterized-by-keratolenticular-dysgenesis-and-ectopia-lentis
#18
Dezső David, Deepti Anand, Carlos Araújo, Brian Gloss, Joana Fino, Marcel Dinger, Päivi Lindahl, Minna Pöyhönen, Laivuori Hannele, João Lavinha
Keratolenticular dysgenesis (KLD) and ectopia lentis are congenital eye defects. The aim of this study is the identification of molecular genetic alterations responsible for those ocular anomalies with neurologic impairment in an individual with a de novo balanced chromosome translocation t(11;18)(q23.3;q11.2)dn. Disruption of OAF, the human orthologue of the Drosophila oaf, by the 11q23.3 breakpoint results in reduced expression of this transcriptional regulator. Furthermore, four most likely nonfunctional chimeric transcripts comprising up to OAF exon 3, derived from the der(11) allele, have also been identified...
January 2, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29298770/mogamulizumab-tops-standard-of-care-for-ctcl
#19
(no author information available yet)
In the large international phase III MAVORIC trial, patients with previously treated cutaneous T-cell lymphoma who received the anti-CCR4 monoclonal antibody mogamulizumab experienced significantly longer progression-free survival and higher response rates, as well as better quality of life, than those who received vorinostat, a standard therapy.
January 3, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29296637/primary-cutaneous-anaplastic-large-cell-lymphoma-complete-remission-for-13%C3%A2-years-after-denileukin-diftitox
#20
Daniel J Lewis, Harry Dao, Priyadharsini Nagarajan, Madeleine Duvic
No abstract text is available yet for this article.
November 2017: JAAD Case Reports
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