keyword
https://read.qxmd.com/read/38057037/crocetin-ameliorative-effect-on-diabetic-nephropathy-in-rats-through-a-decrease-in-transforming-growth-factor-%C3%AE-and-an-increase-in-glyoxalase-i-activity
#21
JOURNAL ARTICLE
Mohammad Mazani, Sina Mahdavifard, Alireza Koohi
BACKGROUND & AIMS: Glycation, oxidative stress, and inflammation due to the elevation of transforming growth factor-β1 (TGF-β1) participate in diabetic nephropathy (DN). Thus, we investigated for the first time the effect of crocetin (Crt) on the renal histopathological parameters, TGF-β1 and glycation, oxidative stress, as well as inflammatory markers in the DN rat model. METHODS: Forty male Wistar rats were randomly divided into 4 equal groups: normal (N), N + Crt, DN, and DN + Crt...
December 2023: Clinical Nutrition ESPEN
https://read.qxmd.com/read/38039734/simultaneous-electrochemical-detection-of-glycated-and-human-serum-albumin-for-diabetes-management
#22
JOURNAL ARTICLE
Monalisha Ghosh Dastidar, Krishnan Murugappan, David R Nisbet, Antonio Tricoli
Developing highly selective and sensitive biosensors for diabetes management blood glucose monitoring is essential to reduce the health risks associated with diabetes. Assessing the glycation (GA) of human serum albumin (HSA) serves as an indicator for medium-term glycemic control, making it suitable for assessing the efficacy of blood glucose management protocols. However, most biosensors are not capable of simultaneous detection of the relative fraction of GA to HSA in a clinically relevant range. Here, we report an effective miniaturised biosensor architecture for simultaneous electrochemical detection of HSA and GA across relevant concentration ranges...
November 26, 2023: Biosensors & Bioelectronics
https://read.qxmd.com/read/38027114/early-detection-of-type-2-diabetes-risk-limitations-of-current-diagnostic-criteria
#23
JOURNAL ARTICLE
Jiale Zhang, Zhuoya Zhang, Kaiqi Zhang, Xiaolei Ge, Ranran Sun, Xu Zhai
Type 2 diabetes (T2D) is the leading cause of diabetes worldwide and is increasing rapidly, especially in youth. It accounts for most diabetes deaths in adults ≥20 years old in the Americas, with type 2 diabetes responsible for most of the disease burden. The incidence and burden of type 2 diabetes in adolescents and young adults have risen in recent decades globally. Countries with lower socioeconomic status had the highest incidence and burden, and females generally had higher mortality and disease burden than males at ages <30 years...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/38016044/nanolc-timstof-assisted-analysis-of-glycated-albumin-in-diabetes-affected-plasma-and-tears
#24
JOURNAL ARTICLE
Yanqi Tan, Eduardo De La Toba, Stanislav S Rubakhin, Leanne T Labriola, Christine Canfield, Dipanjan Pan, Jonathan V Sweedler
Glycation is a spontaneous and nonenzymatic glycosylation. Glycated albumin (GA), which serves as an important biomarker in plasma in the diagnosis and characterization of diabetes, can be passively filtered from the plasma to tears. Tears are important targets for research in clinical diagnostics due to the ability to collect this biofluid noninvasively and repeatably. Therefore, the analysis of GA in tear film provides information for monitoring diabetes progression independent of blood pathologies. Due to the limited volume (1-5 μL) of natural tear film, we developed a small volume assay using a nano liquid chromatography-trapped ion mobility spectrometry-time-of-flight MS (nanoLC-timsTOF) platform for the analysis of glycated albumin in human plasma and tear films affected by diabetes...
November 28, 2023: Journal of the American Society for Mass Spectrometry
https://read.qxmd.com/read/37982266/albumin-from-sera-of-rheumatoid-arthritis-patients-share-multiple-biochemical-biophysical-and-immunological-properties-with-in%C3%A2-vitro-generated-glyco-nitro-oxidized-albumin
#25
JOURNAL ARTICLE
Akhlas Tarannum, Zarina Arif, Mohd Mustafa, Khursheed Alam, Moinuddin, Safia Habib
The purpose of the present study is to explore the effects of endogenous stressors on structure and function of rheumatoid arthritis (RA) patients' albumin. In contrast to glycated-albumin or nitro-oxidized-albumin, high titre antibodies against glyco-nitro-oxidized-albumin were found in the sera of RA patients. Also, compared to the other two modified forms of albumin, glyco-nitro-oxidized-albumin showed highest percent inhibition. Albumin isolated from RA patients' sera displayed hyperchromicity and quenching of tyrosine and tryptophan fluorescence...
November 20, 2023: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/37932245/a-longitudinal-study-of-plasma-glycated-albumin-across-pregnancy-and-associations-with-maternal-characteristics-and-cardiometabolic-biomarkers
#26
JOURNAL ARTICLE
Wei Wei Pang, Stefanie N Hinkle, Jing Wu, Paulina Stallcup, Michael Y Tsai, David B Sacks, Cuilin Zhang
BACKGROUND: Glycated albumin (GA) has recently been proposed as a screening marker for diabetes among non-pregnant individuals. However, data on GA during pregnancy are sparse and lacking among women of diverse race/ethnicity. We investigated longitudinal concentrations of GA among multiracial pregnant women in the National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies-Singletons. METHODS: We quantified GA and cardiometabolic biomarkers using longitudinal plasma samples collected at 10 to 14, 15 to 26 (fasting), 23 to 31, and 33 to 39 gestational weeks from 214 pregnant women without gestational diabetes...
November 2, 2023: Clinical Chemistry
https://read.qxmd.com/read/37903872/tailoring-fpox-enzymes-for-enhanced-stability-and-expanded-substrate-recognition
#27
JOURNAL ARTICLE
Hajar Estiri, Shapla Bhattacharya, Jhon Alexander Rodriguez Buitrago, Rossella Castagna, Linda Legzdiņa, Giorgia Casucci, Andrea Ricci, Emilio Parisini, Alfonso Gautieri
Fructosyl peptide oxidases (FPOX) are deglycating enzymes that find application as key enzymatic components in diabetes monitoring devices. Indeed, their use with blood samples can provide a measurement of the concentration of glycated hemoglobin and glycated albumin, two well-known diabetes markers. However, the FPOX currently employed in enzymatic assays cannot directly detect whole glycated proteins, making it necessary to perform a preliminary proteolytic treatment of the target protein to generate small glycated peptides that can act as viable substrates for the enzyme...
October 30, 2023: Scientific Reports
https://read.qxmd.com/read/37867631/the-association-of-the-triglyceride-and-muscle-to-fat-ratio-during-early-pregnancy-with-the-development-of-gestational-diabetes-mellitus
#28
JOURNAL ARTICLE
Fang Wang, Yuan-Yuan Bao, Kang Yu
OBJECTIVE: This study explored the association between metabolic factors and body composition during the first trimester of gestational diabetes mellitus (GDM). METHODS: This prospective study recruited pregnant women in their first trimester. Clinical information and glucose and lipid measurements were collected, and body composition was assessed using multifrequency bioelectrical impedance analysis. GDM was diagnosed on the basis of an oral glucose tolerance test at 24-28 gestational week...
2023: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/37841770/undetectable-high-performance-liquid-chromatography-haemoglobin-a1c-on-variant-haemoglobin-e-phenotype-a-case-report
#29
Nadia Sadriani, Ferdy Royland Marpaung
The gold standard for long-term monitoring of diabetic patients is glycated haemoglobin (HbA1c), which is routinely tested for glycaemic control. Furthermore, the National glycohemoglobin standardization program (NGSP) has designated high-performance liquid chromatography (HPLC) as the reference method for HbA1c measurement. A woman from the Sumba tribe, Indonesia, aged 52, visited the Internal Medicine Clinic for a routine check-up. She had been taking diabetic and hypertension medicines on a regular basis for over 10 years...
October 15, 2023: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://read.qxmd.com/read/37794537/evaluation-of-salivary-glycated-albumin-in-periodontitis-patients-with-and-without-type-2-diabetes-mellitus-and-its-changes-with-non-surgical-periodontal-therapy
#30
JOURNAL ARTICLE
K M Seniya, K V Baiju, R Ambili
BACKGROUND: Bidirectional relationship exists between diabetes mellitus and periodontitis. Glycated albumin is an emerging biomarker to assess intermediate glycemic control. Salivary glycated albumin has not been evaluated in periodontitis. AIM: The aim of the study was to compare salivary glycated albumin in periodontitis patients with and without diabetes mellitus before and after periodontal therapy. MATERIALS AND METHODS: This comparative cross-sectional study was conducted in the Department of Periodontics...
September 2023: Nigerian Journal of Clinical Practice
https://read.qxmd.com/read/37760819/blood-biomarkers-for-glucose-metabolism-in-preterm-infants
#31
JOURNAL ARTICLE
Mia O Bjerager, Bo M Hansen, Frederik Sørensen, Jes R Petersen, Kristian V Jensen, Brian R Hjelvang, Anna C Hvelplund, Dorte A Olsen, Aneta A Nielsen, Julie L Forman, Ivan Brandslund, Gorm Greisen, Carina Slidsborg
This was an exploratory, prospective, longitudinal, cohort study that aimed to establish "healthy" reference levels related to growth parameters and glucose metabolites in preterm infants. This was conducted to further investigate growth and metabolic disturbances potentially related to neonatal illness. The study sample consisted of 108 preterm infants born before 32 weeks in 2018-2019 in the Capital Region of Denmark. Repetitive blood samples were acquired at the neonatal wards, while clinical data were obtained from the regional hospital medical record system...
August 24, 2023: Biomedicines
https://read.qxmd.com/read/37757966/glycated-serum-proteins-and-albumin-but-not-glycated-albumin-show-negative-correlation-with-bmi-in-an-overweight-obese-diabetic-population-from-the-united-states
#32
JOURNAL ARTICLE
Jennifer Powers Carson, Jyoti Arora
BACKGROUND AND AIMS: Multiple previously published studies have shown a weak to medium, negative correlation between BMI and glycated albumin (GA). However, many of these studies were in populations with a narrow range of BMI. It is unknown whether this trend exists if a wider BMI range is used. This is an important question for proper interpretation of GA levels in obese populations. MATERIALS AND METHODS: A retrospective analysis of clinical trial data (NCT02519309) was performed...
September 25, 2023: Clinical Biochemistry
https://read.qxmd.com/read/37722840/establishment-of-a-reference-interval-for-glycated-albumin-based-on-medical-check-up-data-from-multiple-medical-institutions
#33
JOURNAL ARTICLE
Masafumi Koga, Ikki Shimizu, Yasuko Nakamura, Minoru Yamakado
Objectives: Data were collected to establish a reference interval for glycated albumin (GA), as well as to calculate a cutoff value for diagnosing diabetes mellitus and the GA level corresponding to a 75-g oral glucose tolerance test (OGTT) 2 h plasma glucose (2h-PG) level of 200 mg/dL. Methods: This study involved 1,843 subjects who were undergoing medical check-ups at several medical institutions and whose HbA1c and GA levels had been measured by OGTT. Results: The GA reference interval that was calculated based on the data obtained from study subjects with normal glucose tolerance was 12...
September 18, 2023: Scandinavian Journal of Clinical and Laboratory Investigation
https://read.qxmd.com/read/37693326/fructosamine-is-not-a-reliable-test-for-the-detection-of-hyperglycemia-insight-from-the-africans-in-america-study
#34
JOURNAL ARTICLE
Jean de Dieu Gatete, Charlita C Worthy, Ram Jagannathan, Christopher W DuBose, David B Sacks, Anne E Sumner
OBJECTIVE: To improve detection of abnormal glucose tolerance (Abnl-GT), attention has moved beyond the oral glucose tolerance test (OGTT), to non-fasting markers of glycemia, specifically, HbA1c, fructosamine (FA) and glycated albumin (GA). Emerging data suggest that in African descent populations, the combination of HbA1c and GA is superior to the combination of HbA1c and FA. However, the diagnosis of Abnl-GT is usually based on tests which are performed only once. As reproducibility of Abnl-GT diagnosis by HbA1c, fructosamine (FA) and glycated albumin (GA) is unknown, reproducibility of Abnl-GT diagnosis by HbA1c, FA and GA were assessed in 209 African-born Blacks living in America...
2023: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/37642758/pyridoxamine-protects-human-granulosa-cells-against-advanced-glycation-end-products-induced-steroidogenesis-disturbances
#35
JOURNAL ARTICLE
Maryam Mirani, Soghra Bahmanpour, Fatemeh Masjedi, Zahra Derakhshan, Mahintaj Dara, Mohammad Hossein Nasr-Esfahani, Seyed Mohammad Bagher Tabei
BACKGROUND: Ovarian advanced glycation end-products (AGEs) accumulation is associated with ovarian granulosa cells (GCs) dysfunction. Vitamin B6 derivatives positively affected reproduction. The current study was conducted to elucidate the AGEs effects on human luteinized mural GCs steroidogenesis in the presence or absence of pyridoxamine (PM). METHODS AND RESULTS: Isolated GCs of 50 healthy women were divided into four parts and treated with media alone (Control), PM alone, or human glycated albumin (HGA) with/without PM...
August 29, 2023: Molecular Biology Reports
https://read.qxmd.com/read/37640051/glycated-albumin-and-glycemia-in-pregnancy-and-postpartum-a-pilot-study
#36
JOURNAL ARTICLE
Marti D Soffer, Kaitlyn E James, Tanayott Thaweethai, Michael Callahan, William H Barth, Camille E Powe
OBJECTIVE:  Percent glycated albumin (%GAlb) is a marker of glycemia over the past 2 to 3 weeks in nonpregnant individuals. Longitudinal changes in %GAlb extending throughout pregnancy and postpartum (PP) have not been described. We aimed to describe levels of %GAlb throughout pregnancy and PP and relationships with glycemia. STUDY DESIGN:  Fifty women among those in the Study of Pregnancy Regulation of INsulin and Glucose cohort underwent 75-g oral glucose tolerance tests (OGTTs) at a mean of 13 weeks (V1) and 26 weeks (V2) of gestation and 11 weeks' PP...
August 28, 2023: American Journal of Perinatology
https://read.qxmd.com/read/37637272/beta-1-3-1-6-glucans-produced-by-two-novel-strains-of-aureobasidium-pullulans-exert-immune-and-metabolic-beneficial-effects-in-healthy-middle-aged-japanese-men-results-of-an-exploratory-randomized-control-study
#37
JOURNAL ARTICLE
N Ikewaki, T Sonoda, G Kurosawa, M Iwasaki, V Devaprasad Dedeepiya, R Senthilkumar, S Preethy, S J K Abraham
OBJECTIVES: In this pilot study, we have evaluated the specific metabolic and immune-related benefits of the AFO-202 strain and N-163 strain of black yeast Aureobasidium pullulans-produced beta 1,3-1,6 glucan in healthy human subjects. METHODS: Sixteen healthy Japanese male volunteers (aged 40 to 60 years) took part in this clinical trial. They were divided into four groups (n = 4 each): Group I consumed AFO-202 beta-glucan (2 sachets of 1 g each per day), IA for 35 days and IB for 21 days; Group II consumed a combination of AFO-202 beta-glucan (2 sachets of 1 g each) and N-163 beta-glucan (1 sachet of 15 g gel each per day), IIA for 35 days and IIB for 21 days...
2023: JAR Life
https://read.qxmd.com/read/37629742/differential-association-of-glycation-products-with-bone-mineral-density-and-fat-mass-in-healthy-and-diabetes-type-2-subjects-from-mexican-southeastern-a-cross-sectional-study
#38
JOURNAL ARTICLE
Fernando Ferreyro-Bravo, Ángel Ceballos-Cruz, Mary Jose Urruchua-Rodríguez, Gabriela Martínez-Reyes, Carolina Cortés-Pastrana, Elda Leonor Pacheco-Pantoja
Background : Glycation products have been linked to decreased bone mineral density (BMD) in a number of clinical settings. This study examined the correlation between early glycation products (HbA1c and glycated albumin (ALB-g)) and advanced glycation end products (pentosidine (PTD)) with BMD in two groups of participants: those with type 2 diabetes mellitus (DM2) and those without diabetes or any other comorbidities (noDM). All of the participants had resided in southeastern Mexico for a minimum of 10 years...
August 11, 2023: Medicina
https://read.qxmd.com/read/37577996/clinical-value-of-mir-23a-3p-expression-in-early-diagnosis-of-diabetic-kidney-disease
#39
JOURNAL ARTICLE
Xiaomei Meng, Xiao Yu, Peipei Lei
INTRODUCTION: The objective was to observe the expression of miR-23a-3p in the serum of patients with type 2 diabetic nephropathy (T2DN) and to explore its clinical significance. MATERIALS AND METHODS: 112 patients with type 2 diabetes were divided into a simple diabetes mellitus (NON) group, T2DN microalbuminuria (MIC) group, and T2DN macroalbuminuria (MAC) group, according to the urinary protein-creatinine ratio (uACR). Clinical data were collected, miR-23a-3p levels in serum were measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR), and clinical parameters were measured by an automatic biochemical analyser; the influencing factors of diabetic kidney disease (DKD) and the correlation between miR-23a-3p expression and clinical parameters were analysed...
August 14, 2023: Endokrynologia Polska
https://read.qxmd.com/read/37568043/bi-weekly-glycated-albumin-measurement-was-useful-to-encourage-behavioral-changes-in-people-with-type%C3%A2-2-diabetes-mellitus
#40
JOURNAL ARTICLE
Masakazu Aihara, Takanori Hayashi, Chie Koizumi, Yoshitaka Sakurai, Mika Sawada, Tetsuya Kubota, Takashi Kadowaki, Toshimasa Yamauchi, Naoto Kubota
INTRODUCTION: Hemoglobin A1c (HbA1c), representing the average blood glucose over 1-2 months, is the most commonly used glycemic marker in people with diabetes. Glycated albumin (GA) reflects the average blood glucose over the most recent 1-2 weeks. We considered whether the faster response of GA compared with HbA1c could make people with diabetes realize their glycemic control intuitively and effectively. METHODS: We randomized 61 people with diabetes into the control and intervention groups...
August 11, 2023: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
keyword
keyword
53174
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.