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"Glycated albumin"

Andrew N Reynolds, Jim I Mann, Sheila Williams, Bernard J Venn
AIMS/HYPOTHESIS: Regular physical activity is a cornerstone of diabetes management. We conducted a study to evaluate whether specifying the timing of walking in relation to meals enhances the benefits conferred by current physical activity guidelines. METHODS: A total of 41 adults with type 2 diabetes mellitus (mean ± SD age 60 ± 9.9 years; mean diabetes duration 10 years) participated in this randomised, crossover study. Randomisation was by a computer-generated protocol...
October 17, 2016: Diabetologia
Christina W Chen, Christiane Drechsler, Pirianthini Suntharalingam, S Ananth Karumanchi, Christoph Wanner, Anders H Berg
BACKGROUND: Monitoring of glycemic control with hemoglobin A1c (A1c) in hemodialysis patients may be compromised by anemia and erythropoietin therapy. Glycated albumin (GA) is an alternative measure of glycemic control but is not commonly used because of insufficient evidence of association to clinical outcomes. We tested whether GA measurements were associated with mortality in hemodialysis patients with diabetes mellitus. METHODS: The German Diabetes and Dialysis Study (4D) investigated effects of atorvastatin on survival in 1255 patients with diabetes mellitus receiving hemodialysis...
October 13, 2016: Clinical Chemistry
Megha Reddy, Basanth Kumar
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Renata Paleari, Marta Strollo, Elena Guerra, Ferruccio Ceriotti, Andrea Mosca
BACKGROUND: The determination of glycated albumin (GA) has been suggested as an additional parameter having an independent added value respect to that of HbA1c. The determination of glycation gap (gg) has also been proposed, but few studies have addressed its potential impact in the routine evaluation of glycometabolic control. METHODS: A total of 157 subjects presenting normal whole blood cell count, no hemoglobin variants, normal creatinine levels and serum protein electrophoresis patterns were studied...
October 5, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
Masafumi Koga, Rie Matsumoto
BACKGROUNDS: The effect of alcohol consumption on glycemic control indicators is not well known. In this study, we studied the effect of alcohol consumption on the plasma glucose and glycemic control indicators in non-diabetic men. METHODS: The study enrolled 300 non-diabetic men who received a complete medical checkup [age: 52.8 ± 6.5 years, body mass index (BMI): 24.4 ± 2.8 kg/m(2)]. The subjects were divided into four groups by the amount of alcohol consumed, and the plasma glucose, HbA1c, glycated albumin (GA), and 1,5-anhydroglucitol (1,5-AG) levels of the groups were compared...
October 4, 2016: Annals of Clinical Biochemistry
Rosa M Montero, Gurjeet Bhangal, Charles D Pusey, Andrew H Frankel, Frederick W K Tam
BACKGROUND: Diabetic nephropathy is the leading cause of end stage kidney disease worldwide. The pathogenesis of this disease remains elusive and multiple factors have been implicated. These include the effects of hyperglycaemia, haemodynamic and metabolic factors, and an inflammatory process that stimulates cellular signalling pathways leading to disease progression and severe fibrosis. Fibronectin (Fn) is an important protein of the extracellular matrix that is essential in fibrosis and its presence in increased amounts has been identified in the kidney in diabetic nephropathy...
September 29, 2016: BMC Nephrology
Anne E Sumner, Michelle T Duong, Brianna A Bingham, Paola C Aldana, Madia Ricks, Lilian S Mabundo, Marshall K Tulloch-Reid, Stephanie T Chung, David B Sacks
BACKGROUND: Following immigration to the US, many Africans transition from a low-normal to a high-normal or overweight body mass index (BMI). This weight change is associated with a high rate of prediabetes in the nonobese. Studies in East Asians reveal that glycated albumin is effective in identifying prediabetes in nonobese Asians. Whether this is true in African immigrants is unknown. Therefore, we evaluated the ability of hemoglobin A1c (Hb A1c) and glycated albumin to detect prediabetes in nonobese (BMI <30 kg/m(2)) and obese (BMI ≥30 kg/m(2)) African immigrants...
September 13, 2016: Clinical Chemistry
Elena Dozio, Nicola Di Gaetano, Peter Findeisen, Massimiliano Marco Corsi Romanelli
This review summarizes current knowledge about glycated albumin. We review the changes induced by glycation on the properties of albumin, the pathological implications of high glycated albumin levels, glycated albumin quantification methods, and the use of glycated albumin as a complementary biomarker for diabetes mellitus diagnosis and monitoring and for dealing with long-term complications. The advantages and limits of this biomarker in different clinical settings are also discussed.
September 13, 2016: Endocrine
Danielle Desjardins, Yueying Liu, Craig E Crosson, Zsolt Ablonczy
In diabetic individuals, macular edema is a major cause of vision loss. This condition is refractory to insulin therapy and has been attributed to metabolic memory. The retinal pigment epithelium (RPE) is central to maintaining fluid balance in the retina, and this function is compromised by the activation of advanced glycation end-product receptors (RAGE). Here we provide evidence that acute administration of the RAGE agonist, glycated-albumin (gAlb) or vascular endothelial growth factor (VEGF), increased histone deacetylase (HDAC) activity in RPE cells...
2016: PloS One
Akinori Hayashi, Koji Takano, Tsuguto Masaki, Sonomi Yoshino, Akifumi Ogawa, Masayoshi Shichiri
AIMS: HbA1c and glycated albumin (GA) are used to monitor glycemia, but their accuracy to represent glycemic profiles in hemodialysis remains controversial. METHODS: Continuous glucose monitoring in 97 patients with type 2 diabetes (41 on hemodialysis [HD] and 56 without nephropathy) was analyzed to evaluate whether HbA1c and/or GA serve as appropriate glycemic profile markers. RESULTS: The average glucose significantly correlated with HbA1c in both HD group and group without nephropathy (r=0...
November 2016: Journal of Diabetes and its Complications
Nana Wang, Chuanji Guo, Ping Han, Tiegang Li
AIMS: We investigated associations between serum levels of glycated albumin (GA) and glycated hemoglobin (HbA1c) and the presence of diabetic peripheral neuropathy (DPN) in patients with type 1 diabetes mellitus (T1DM). METHODS: Between September 2009 and April 2015, we evaluated 314 patients with T1DM in the Endocrinology Department of Shengjing Hospital of China Medical University. We divided the patients into the DPN group (n = 72) and the non-DPN group (n = 242), on the basis of the presence of DPN...
August 30, 2016: Acta Diabetologica
Ali Akbar Moosavi-Movahedi, Naghmeh Sattarahmady, Esmaeil Sharifi, Hossein Heli
BACKGROUND: Protein aggregation is one of the important, common and troubling problems in biotechnology, pharmaceutical industries and amyloid-re-lated disorders. METHODS: In the present study, the inhibitory effects of some carbohydrates (alginate, β-cyclodextrin and trehalose) on the formation of nano-globular aggregates from normal (HSA) and glycated (GHSA) human serum albumin were studied; when the formation of aggregates was induced by the simultaneous heating and addition of dithiotheritol...
July 2016: Avicenna Journal of Medical Biotechnology
Katsuhito Mori, Masanori Emoto, Tetsuo Shoji, Masaaki Inaba
OBJECTIVE: Focusing on efficacy and tolerability, we compared linagliptin monotherapy with voglibose monotherapy in patients with type 2 diabetes undergoing hemodialysis (HD). RESEARCH DESIGN AND METHODS: In this multicenter, randomized, open-label, parallel-group, active-controlled study, 78 patients were randomized (1:1) to receive a 12-week treatment with 5 mg linagliptin once daily or 0.2 mg voglibose three times a day. To assess whether linagliptin was superior to voglibose, the primary efficacy end point was the change in glycated hemoglobin (HbA1c) level between baseline and week 12...
2016: BMJ Open Diabetes Research & Care
Nana Wang, Zhen Xu, Ping Han, Tiegang Li
BACKGROUND: We investigated the association between serum levels of glycated albumin (GA), glycated hemoglobin (HbA1c) and GA/HbA1c ratio and the presence of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM). METHODS: 206 consecutive patients with T2DM were enrolled from the endocrinology ward at Shengjing Hospital of the China Medical University, and classified into two groups: DN group (n =71) and diabetic non-nephropathy (non-DN) group (n = 135)...
August 18, 2016: Diabetes/metabolism Research and Reviews
Mika Hatada, Wakako Tsugawa, Eri Kamio, Noya Loew, David C Klonoff, Koji Sode
Glycated proteins, such as glycated hemoglobin (HbA1c) or glycated albumin (GA) in the blood, are essential indicators of glycemic control for diabetes mellitus. Since GA, compared to HbA1c, is more sensitive to short term changes in glycemic levels, GA is expected to be used as an alternative or together with HbA1c as a surrogate marker indicator for glycemic control. In this paper we report the development of a sensing system for measuring GA by combining an enzyme analysis method, which is already used in clinical practice, with electrochemical principles...
August 3, 2016: Biosensors & Bioelectronics
Ju-Ming Lu, Li-Nong Ji, Yu-Feng Li, Quan-Min Li, Shan-Shan Lin, Xiao-Feng Lv, Li Wang, Yuan Xu, Xiao-Hui Guo, Qi-Yu Guo, Li Ma, Jin Du, Ying-Li Chen, Cui-Ling Zhao, Qiu-Lan Zhang, Qi-Mei She, Xiu-Min Jiao, Mei-Hua Lu, Rong-Qing Pan, Ying Gao
AIMS: This study was to determine whether serum glycated albumin (GA) was a better indicator of glycemic control than hemoglobin A1c (HbA1c) when starting a new treatment regimen for type 2 diabetes. METHODS: Newly diagnosed type 2 diabetes patients, or patients who had poor glycemic control with oral hypoglycemic agents, were enrolled at 10 hospitals in Beijing. Serum GA, HbA1c, fasting blood glucose (FBG), and C-peptide were assayed on Days 0, 14, 28, and 91 after treatment...
November 2016: Journal of Diabetes and its Complications
Roberto Testa, Ferruccio Ceriotti, Elena Guerra, Anna Rita Bonfigli, Massimo Boemi, Michela Cucchi, Nicola Di Gaetano, Gabriele Santini, Stefano Genovese, Antonio Ceriello
No abstract text is available yet for this article.
July 26, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
Chunye Chen, Yuan Zeng, Jing Xu, Hongting Zheng, Jun Liu, Rong Fan, Wenyi Zhu, Lijia Yuan, Yu Qin, Shihui Chen, Yong Zhou, Ying Wu, Jing Wan, Mantian Mi, Jian Wang
Soluble dietary fiber (DF) reduces the risk of developing diabetes and may have therapeutic effects in patients with type 2 diabetes mellitus (DM2). The present study aimed to investigate the effect of soluble DF on metabolic control in patients with DM2. A total of 117 patients with DM2 between the ages of 40 and 70 were assessed. Patients were randomly assigned to one of two groups, and administered extra soluble DF (10 or 20 g/day), or to a control group (0 g/day) for one month. Blood glucose, serum insulin and connecting peptide (C-peptide) levels, and the insulin resistance index, as determined using the homeostatic model assessment method, were measured during fasting and up to 2-h postprandially prior to and following one month of treatment...
August 2016: Experimental and Therapeutic Medicine
Diego Juvenal Gomes, Ana Paula Velosa, Ligia Shimabukuro Okuda, Fernanda Bueno Fusco, Karolinne Santana da Silva, Paula Ramos Pinto, Edna Regina Nakandakare, Maria Lucia Correa-Giannella, Tom Woods, Margaret Anne Brimble, Russell Pickford, Kerry-Anne Rye, Walcy Rosolia Teodoro, Sergio Catanozi, Marisa Passarelli
AIMS: Advanced glycated albumin (AGE-albumin) adversely impairs macrophage lipid homeostasis in vitro, which may be prevented by angiotensin receptor blockers. In vivo studies are inconclusive whether AGE-albumin itself plays important role in early-stage atherogenesis. We aimed at investigating how AGE-albumin by itself drives atherosclerosis development in dyslipidemic non-diabetic mice and if its effects are due to the activation of renin-angiotensin system in the arterial wall and the expression of genes and proteins involved in lipid flux...
November 2016: Journal of Diabetes and its Complications
Naeimeh Jafari, Rashik Ahmed, Melanie Gloyd, Jonathon Bloomfield, Philip Britz-McKibbin, Giuseppe Melacini
Human serum albumin (HSA) serves not only as a physiological oncotic pressure regulator and a ligand carrier but also as a biomarker for pathologies ranging from ischemia to diabetes. Moreover, HSA is a biopharmaceutical with a growing repertoire of putative clinical applications from hypovolemia to Alzheimer's disease. A key determinant of the physiological, diagnostic, and therapeutic functions of HSA is the amount of long chain fatty acids (LCFAs) bound to HSA. Here, we propose to utilize (13)C-oleic acid for the NMR-based assessment of albumin-bound LCFA concentration (CONFA)...
August 25, 2016: Journal of Medicinal Chemistry
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