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"Glycated albumin"

Yuanpeng Li, Fucui Li, Xinhao Yang, Liu Guo, Furong Huang, Zhenqiang Chen, Xingdan Chen, Shifu Zheng
A rapid quantitative analysis model for determining the glycated albumin (GA) content based on Attenuated total reflectance (ATR)-Fourier transform infrared spectroscopy (FTIR) combining with linear SiPLS and nonlinear SVM has been developed. Firstly, the real GA content in human serum was determined by GA enzymatic method, meanwhile, the ATR-FTIR spectra of serum samples from the population of health examination were obtained. The spectral data of the whole spectra mid-infrared region (4000-600 cm-1 ) and GA's characteristic region (1800-800 cm-1 ) were used as the research object of quantitative analysis...
May 7, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Ning Ding, Lucia Kwak, Shoshana H Ballew, Bernard Jaar, Ron C Hoogeveen, Christie M Ballantyne, A Richey Sharrett, Aaron R Folsom, Gerardo Heiss, Maya Salameh, Josef Coresh, Alan T Hirsch, Elizabeth Selvin, Kunihiro Matsushita
BACKGROUND AND AIMS: Traditional glycemic markers, fasting glucose and hemoglobin A1c (HbA1c), predict incident peripheral artery disease (PAD). However, it is unknown whether nontraditional glycemic markers, fructosamine, glycated albumin, and 1,5-anhydroglucitol, are associated with PAD and whether these glycemic markers demonstrate particularly strong associations with severe PAD, critical limb ischemia (CLI). METHODS: We quantified the associations of these five glycemic markers with incident PAD (hospitalizations with PAD diagnosis or leg revascularization) in 11,634 ARIC participants using Cox regression models...
April 30, 2018: Atherosclerosis
Siena Duarte, Tina Hoang, Susan K Ewing, Peggy M Cawthon, Steve Cummings, Katie L Stone, Jane A Cauley, Douglas C Bauer, Teresa A Hillier, Kristine Yaffe
Background: The association between diabetes and dementia may be explained in part by elevated levels of glycated peptides; we sought to determine if serum glycated peptides predicted cognitive decline in non-diabetic older adults. Methods: We prospectively studied 525 community-dwelling non-diabetic women, mean age of 82 years, and analyzed baseline glycated peptides (serum level of fructosamine and glycated albumin). Cognitive outcomes included 5-year decline on the short Mini-Mental State Examination (sMMSE), Trails B, and performance on a battery of five other cognitive tests at the follow-up visit...
May 7, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Todd W Robinson, Barry I Freedman
No abstract text is available yet for this article.
March 21, 2018: Nephrology, Dialysis, Transplantation
Christine L Chan, Emma Hope, Jessica Thurston, Timothy Vigers, Laura Pyle, Philip S Zeitler, Kristen J Nadeau
OBJECTIVE: In cystic fibrosis (CF), HbA1c is thought to underestimate glycemia. However, few studies have directly assessed the relationship between HbA1c and average glucose in CF. We determined the relationships among glycemic markers-HbA1c , fructosamine (FA), glycated albumin (%GA), and 1,5-anhydroglucitol (1,5-AG)-and continuous glucose monitoring (CGM) in CF, hypothesizing that alternate markers would better predict average sensor glucose (ASG) than HbA1c . RESEARCH DESIGN AND METHODS: CF participants and a group of healthy control subjects (HC), ages 6-25 years, wore CGM for up to 7 days...
April 19, 2018: Diabetes Care
Nadra Bohli, Olivier Meilhac, Philippe Rondeau, Syrine Gueffrache, Laurence Mora, Adnane Abdelghani
In this paper we propose an easy way to detect the glycated form of human serum albumin which is biomarker for several diseases such as diabetes and Alzheimer. The detection platform is a label free impedimetric immunosensor, in which we used a monoclonal human serum albumin antibody as a bioreceptor and electrochemical impedance as a transducing method. The antibody was deposited onto a gold surface by simple physisorption technique. Bovine serum albumin was used as a blocking agent for non-specific binding interactions...
July 1, 2018: Talanta
I Musha, M Mochizuki, T Kikuchi, J Akatsuka, A Ohtake, K Kobayashi, N Kikuchi, T Kawamura, I Yokota, T Urakami, S Sugihara, S Amemiya
AIMS: To evaluate comprehensively the use of the glycated albumin to HbA1c ratio for estimation of glycaemic control in the previous month. METHODS: A total of 306 children with Type 1 diabetes mellitus underwent ≥10 simultaneous measurements of glycated albumin and HbA1c . Correlation and concordance rates were examined between HbA1c measurements taken 1 month apart (ΔHbA1c ) and glycated albumin/HbA1c ratio fluctuations were calculated as Z-scores from the cohort value at enrolment (method A) or the percent difference from the individual mean over time (method B)...
April 13, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
Xiuzhi Guo, Fang Zhao, Yicong Yin, Danchen Wang, Li'an Hou, Jie Wu, Dandan Li, Xinqi Cheng, Liangyu Xia, Ermu Xu, Ling Qiu
BACKGROUND: We reported that calcium dobesilate, a vasoprotective agent mainly used for diabetic retinopathy (DR), negatively interferes with glycated albumin (GA) assays involving enzymatic methods. METHODS: A calcium dobesilate standard was added to 3serum pools in vitro to prepare concentration-response series according to Clinical and Laboratory Standards Institute EP7-A2 guidelines. Percentage deviation between each drug concentration and the drug-free sample was calculated for 6 commercially available GA assays...
April 10, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Yutaka Umayahara, Yohei Fujita, Hirotaka Watanabe, Noriko Kasai, Noritaka Fujiki, Masahiro Hatazaki, Masafumi Koga
No abstract text is available yet for this article.
April 9, 2018: Clinical Biochemistry
Neuza Mendes, Rogério Tavares Ribeiro, Fátima Serrano
Strict glycaemic management is the cornerstone of metabolic control in gestational diabetes mellitus (GDM). Current monitoring standards involve self-monitoring plasma glucose (SMBG) and haemoglobin A1c (HbA1c). However, both have important limitations. SMBG only reflects instantaneous blood glucose and the inconvenience of self-collecting blood frequently results in poor compliance. HbA1c provides information on blood glucose levels from the previous 2 to 3 months and it is influenced by iron-deficient states, common during pregnancy...
April 5, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Hiroyasu Miyamoto, Xinran Tao, Takuji Kohzuma, Akihiro Ohnishi
No abstract text is available yet for this article.
April 1, 2018: Journal of Diabetes Science and Technology
Aya Umeno, Toshiki Fukui, Yoshiko Hashimoto, Masatoshi Kataoka, Yoshihisa Hagihara, Hidenori Nagai, Masanori Horie, Mototada Shichiri, Kohzoh Yoshino, Yasukazu Yoshida
We previously reported that type 2 diabetes risk, early impaired glucose tolerance and insulin resistance can be predicted by measuring the fasting levels of certain biomarkers. Here we validated these findings in randomly recruited healthy volunteers ( n  = 101) based on biomarker expression as well as various non-invasive indices. Weight, body mass index, waist circumference and visceral fat differed between individuals with impaired fasting glucose and/or impaired glucose tolerance, and normal subjects...
March 2018: Journal of Clinical Biochemistry and Nutrition
Elena Dozio, Valentina Corradi, Marta Proglio, Elena Vianello, Lorenzo Menicanti, Roberta Rigolini, Carlotta Caprara, Massimo de Cal, Massimiliano M Corsi Romanelli, Claudio Ronco
In chronic kidney disease patients on dialysis (CKD-G5D) accurate assessment of glycemic control is vital to improve their outcome and survival. The best glycemic marker for glucose control in these patients is still debated because several clinical and pharmacological factors may affect the ability of the available biomarkers to reflect the patient's glycemic status properly. This review discusses the role of glycated albumin (GA) both as a biomarker for glucose control and as a prognostic factor in CKD-G5D; it also looks at the pros and cons of GA in comparison to the other markers and its usefulness in hemodialysis and peritoneal dialysis...
March 26, 2018: Diabetes Research and Clinical Practice
Z Merhi, E Buyuk, M J Cipolla
STUDY QUESTION: Does vitamin D attenuate the adverse effects of advanced glycation end products (AGEs) on steroidogenesis by human granulosa cells (GCs)? SUMMARY ANSWER: AGEs alter the expression of genes important in steroidogenesis while 1,25-dihydroxyvitamin D3 (vit D3) in vitro attenuates some of the actions of AGEs on steroidogenic gene expression, possibly by downregulating the expression of the pro-inflammatory cell membrane receptor for AGEs (RAGE). WHAT IS KNOWN ALREADY: Vitamin D attenuates the pro-inflammatory effects of AGEs in non-ovarian tissues...
March 12, 2018: Molecular Human Reproduction
Junichi Hoshino, Takayuki Hamano, Masanori Abe, Takeshi Hasegawa, Atsushi Wada, Yoshifumi Ubara, Kenmei Takaichi, Masaaki Inaba, Shigeru Nakai, Ikuto Masakane
Background: For glycemic control in diabetic patients on dialysis it was unclear what level of glycated albumin (GA) was associated with the lowest mortality and GA's utility. Accordingly, we examined the difference in association between GA and hemoglobin A1c (HbA1c) with 1-year mortality in a cohort of the Japanese Society for Dialysis Therapy. Methods: We examined 84 282 patients with prevalent diabetes who were on maintenance hemodialysis (HD) (female 30.3%; mean age 67...
March 8, 2018: Nephrology, Dialysis, Transplantation
Yanping Liu, Ju Qiu, Yanfen Yue, Kang Li, Guixing Ren
Introduction: Although black-grained wheat (BGW) is recognized as a nutritional food for humans in China, it has yet to be utilized well for industrial applications, which can be attributed to the limited research data available on its health benefits. Thus, the hypothesis was tested that a daily substitution of BGW for a partial staple food would improve glycemia and inflammatory profile of type 2 diabetes mellitus (T2DM) patients by a randomized controlled trial. Materials and methods: A total of 120 patients were randomly divided between control group (diet control and nutritional education) and BGW group (daily substitution of BGW for a partial staple food)...
2018: Therapeutics and Clinical Risk Management
Chiara Bellia, Martina Zaninotto, Chiara Cosma, Luisa Agnello, Giulia Bivona, Mariela Marinova, Bruna Lo Sasso, Mario Plebani, Marcello Ciaccio
OBJECTIVES: Glycated Albumin (GA) has been proposed as a screening marker for diabetes in Asian countries in the last years. Nevertheless, few studies have been conducted in Caucasian population. The aim of this study is to evaluate the clinical usefulness of GA in diabetes diagnosis in Caucasian asymptomatic subjects considered at risk of diabetes based on medical history and Fasting Plasma Glucose (FPG). DESIGN AND METHODS: Three hundred and thirty-four Caucasian subjects having one or more risk factor for diabetes, and/or FPG ranging from 5...
April 2018: Clinical Biochemistry
Ikki Shimizu, Yuji Hiramatsu, Yasue Omori, Masao Nakabayashi
Background To clarify the relationship between glycated haemoglobin and glycated albumin concentrations during pregnancy with neonatal outcomes, a multicentre study was conducted by the Japanese Society of Diabetes and Pregnancy. Methods A total of 136 patients (type 1: n = 47, type 2: n = 89) who enrolled in the study were diagnosed based on the Japanese Diabetes Society diagnostic criteria for diabetes mellitus. Thresholds for glycated haemoglobin and glycated albumin were set at 5.8% and 15.8%, respectively, as the upper limits of the reference interval in pregnant women...
January 1, 2018: Annals of Clinical Biochemistry
Euna Ko, Van-Khue Tran, Yanfang Geng, Min Ki Kim, Ga Hyun Jin, Seong Eun Son, Won Hur, Gi Hun Seong
Self-monitoring of glycated albumin (GA), a useful glycemic marker, is an established method for preventing diabetes complications. Here, the paper-based lateral flow assay devices were developed for the sensitive detection of GA and the total human serum albumin (tHSA) in self-monitoring diabetes patients. Boronic acid-derived agarose beads were packed into a hole on a lateral flow channel. These well-coordinated agarose beads were used to capture GA through specific cis-diol interactions and to enhance the colorimetric signals by concentrating the target molecules...
January 2018: Biomicrofluidics
Kunihiko Hashimoto, Masafumi Koga
Although HbA1c is widely used as a glycemic control indicator, HbA1c is known to show falsely high levels in patients in an iron deficient state (IDS). We compared the influence of IDS on HbA1c levels between pregnant women, due to mainly an increase in demand for iron without bleeding, and non-pregnant women, due to mainly bleeding (menstruation). We studied 42 non-diabetic pregnant women (pregnant group) and 42 age-matched non-pregnant women with normal glucose tolerance (non-pregnant group). We compared HbA1c and glycated albumin (GA) levels between IDS and normal iron state (NIS) in both groups...
February 20, 2018: Journal of Clinical Medicine
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