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"Glycated albumin"

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https://www.readbyqxmd.com/read/27933186/effect-of-type-and-amount-of-dietary-carbohydrate-on-biomarkers-of-glucose-homeostasis-and-c-reactive-protein-in-overweight-or-obese-adults-results-from-the-omnicarb-trial
#1
Stephen P Juraschek, Edgar R Miller, Elizabeth Selvin, Vincent J Carey, Lawrence J Appel, Robert H Christenson, Frank M Sacks
OBJECTIVE: The glycemic index (GI) of dietary carbohydrate is thought to affect glucose homeostasis. Recently, the Effect of Amount and Type of Dietary Carbohydrates on Risk for Cardiovascular Heart Disease and Diabetes Study (OmniCarb) trial reported that a low-GI diet did not improve insulin sensitivity. We conducted this ancillary study of the OmniCarb trial to determine the effects of GI and carbohydrate content on glucose homeostasis and inflammation. RESEARCH DESIGN AND METHODS: OmniCarb was a randomized cross-over feeding study conducted in overweight or obese adults without diabetes (N=163)...
2016: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/27923630/association-of-glycated-albumin-to-hba1c-ratio-with-diabetic-retinopathy-but-not-diabetic-nephropathy-in-patients-with-type-2-diabetes
#2
Yutaka Umayahara, Yohei Fujita, Hirotaka Watanabe, Noriko Kasai, Noritaka Fujiki, Masahiro Hatazaki, Masafumi Koga
OBJECTIVES: The ratio of glycated albumin to HbA1c (GA/HbA1c ratio) is a known indicator that reflects fluctuations in plasma glucose. In this study, the association of the GA/HbA1c ratio to diabetic nephropathy and diabetic retinopathy in patients with type 2 diabetes was investigated. DESIGN AND METHODS: Among patients with type 2 diabetes, 613 patients (364 males and 249 females, aged 63.2±12.5, body mass index (BMI) 25.4±4.8kg/m(2)) were enrolled. Patients with overt proteinuria, reduced renal function, or anemia were excluded...
December 3, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27896233/serum-fructosamine-serum-glycated-albumin-and-serum-glycated-%C3%AE-lipoprotein-in-type-2-diabetes-mellitus-patients-with-and-without-microvascular-complications
#3
Tejaskumar R Kalaria, Habibunnisha B Sirajwala, Mukesh G Gohel
BACKGROUND: Glycation of serum proteins has been proposed as an important mechanism of complications of diabetes but whether there are differences in glycation of different serum proteins and whether it has any correlation with development of microvascular complications has not been studied in depth. This study aimed to assess level of serum fructosamine, glycated albumin and glycated β-lipoprotein in type 2 diabetes mellitus patients with and without microvascular complications and to find out their correlation with diabetes complications...
2016: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/27890722/diabetes-induced-hepatic-oxidative-stress-a-new-pathogenic-role-for-glycated-albumin
#4
Jessica Patche, Dorothée Girard, Aurélie Catan, Florence Boyer, Anthony Dobi, Cynthia Planesse, Nicolas Diotel, Alexis Guerin-Dubourg, Pascal Baret, Susana B Bravo, Beatriz Paradela-Dobarro, Ezequiel Álvarez, M Faadiel Essop, Olivier Meilhac, Emmanuel Bourdon, Philippe Rondeau
Increased oxidative stress and advanced glycation end-product (AGE) formation are major contributors to the development of type 2 diabetes. Here plasma proteins e.g. albumin can undergo glycoxidation and play a key role in diabetes onset and related pathologies. However, despite recent progress linking albumin-AGE to increased oxidative stress and downstream effects, its action in metabolic organs such as the liver remains to be elucidated. The current study therefore investigated links between oxidative perturbations and biochemical/structural modifications of plasma albumin, and subsequent downstream effects in transgenic db/db mouse livers and HepG2 cells, respectively...
November 24, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27873436/alternate-glycemic-markers-reflect-glycemic-variability-in-continuous-glucose-monitoring-in-youth-with-prediabetes-and-type-2-diabetes
#5
Christine L Chan, Laura Pyle, Megan M Kelsey, Lindsey Newnes, Amy Baumgartner, Philip S Zeitler, Kristen J Nadeau
OBJECTIVE: To determine whether the alternate glycemic markers, fructosamine (FA), glycated albumin (GA), and 1,5-anhydroglucitol (1,5AG), predict glycemic variability captured by continuous glucose monitoring (CGM) in obese youth with prediabetes and type 2 diabetes (T2D). STUDY DESIGN: Youth with BMI ≥85th%ile, 10-18 years, had collection of fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), FA, GA, and 1,5AG and 72 hours of CGM. Participants with HbA1c ≥5...
November 22, 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/27859632/the-establishment-of-biological-reference-intervals-of-nontraditional-glycemic-markers-in-a-chinese-population
#6
Qiang Zhou, De-Bao Shi, Li-Ying Lv
BACKGROUND: We established the reference intervals for glycated albumin (GA), fructosamine (FA), and 1,5-anhydroglucitol (1,5-AG) in a Chinese healthy population. METHODS: This study enrolled a total of 458 eligible reference individuals, consisted of 226 men and 232 women, aged from 20~79 years (median age 43 years), who attending routine healthy checks. We stratified the subjects according to gender (males and females) and age (20-39, 40-59, and 60-79 years), and combined statistical methods with Lahti algorithm, as well as appropriate clinical consideration, to judge whether partitioning for data was needed...
November 17, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27843494/changes-in-antidiabetic-prescription-patterns-and-indicators-of-diabetic-control-among-200-000-patients-over-13%C3%A2-years-at-a-single-institution-in-japan
#7
Kazutoshi Fujibayashi, Michio Hayashi, Hirohide Yokokawa, Toshio Naito
BACKGROUND: We examined the long-term changes in the management of diabetes at a single institution in Japan. METHODS: Two repeated cross-sectional studies and a retrospective cohort study were conducted among patients who visited our institution between 2001 and 2013. We examined the changes in glycated hemoglobin (HbA1c) and glycated albumin levels, the prescription frequencies, and the daily doses of each antidiabetic agent among patients treated regularly for diabetes during the 13-year study period...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27830830/ethnic-differences-in-glucose-homeostasis-markers-between-the-kyushu-okinawa-population-study-and-the-framingham-offspring-study
#8
Hiroaki Ikezaki, Masumi Ai, Ernst J Schaefer, Seiko Otokozawa, Bela F Asztalos, Katsuyuki Nakajima, Yanhua Zhou, Ching-Ti Liu, Paul F Jacques, L Adrienne Cupples, Norihiro Furusyo
We compared markers of glucose homeostasis and their association with diabetes and impaired fasting glucose (IFG) in Fukuoka, Japanese subjects (n = 1108) and age-, gender- and menopausal status-matched participants in the Framingham Offspring Study (n = 1096). The markers examined included fasting glucose, insulin, adiponectin, and glycated albumin, as well as body mass index (BMI), use of medications, and history of diabetes. The results showed that IFG prevalence in Japanese men (15.9%) and women (7...
November 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27829338/electrochemical-biosensor-for-detection-of-glycated-albumin
#9
Edyta Mikuła, Aleksandra Wysłouch-Cieszyńska, Liliya Zhukova, Peter Verwilst, Wim Dehaen, Jerzy Radecki, Hanna Radecka
This paper presents an electrochemical biosensor based on a thiol derivative of a pentetic acid (DPTA) complex with Cu (II) created on a gold electrode surface. His-tagged domains of Receptors for Advanced Glycation End Products (RAGE) have been applied as an analytical active element for the determination of the glycated albumin. DPTA-Cu(II) complex molecules play a double role. They are sites for covalent immobilization of His6- RAGE domains, as well as transducers of the analytical signal. The binding of glycated albumin by His6- RAGE domains causes a variation in the electrochemical properties of the Cu(II) redox centers tethered to the electrode surface...
November 8, 2016: Current Alzheimer Research
https://www.readbyqxmd.com/read/27775182/glycated-albumin-is-associated-with-body-mass-index-in-euglycemic-adults-but-is-not-predictive-of-postprandial-blood-glucose-response
#10
Andrew N Reynolds, Ashley Duncan, Devonia Kruimer, Bernard J Venn
BACKGROUND: The level of glycated albumin in circulation is an indicator of blood glucose control over the preceding 2 weeks. It is not known if the level of glycated albumin in circulation relates to an individual's postprandial blood glucose response. METHODS: Eighty-four euglycemic young adults (21.1 [3.9] years, BMI 23.9 [4.0] kg/m(2) ) primarily of European descent underwent a fasted meal test of 50 g carbohydrate from white bread. Capillary blood was then sampled at regular intervals over 2 hours...
October 24, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27773732/chicken-albumin-exhibits-natural-resistance-to-glycation
#11
Jessica Zuck, Chad R Borges, Eldon J Braun, Karen L Sweazea
Glycation of proteins and subsequent production of advanced glycation end products (AGEs) is a major contributor to the pathophysiology of diabetes. The objective of the present study was to compare the glycation of avian and human serum albumin to elucidate the mechanisms by which protein glycation in birds is prevented in the presence of naturally high plasma glucose concentrations. Solutions of purified chicken and human serum albumin (CSA and HSA) were prepared with four different glucose concentrations (0, 5...
October 20, 2016: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/27747394/advice-to-walk-after-meals-is-more-effective-for-lowering-postprandial-glycaemia-in-type-2-diabetes-mellitus-than-advice-that-does-not-specify-timing-a-randomised-crossover-study
#12
Andrew N Reynolds, Jim I Mann, Sheila Williams, Bernard J Venn
AIMS/HYPOTHESIS: Regular physical activity is a cornerstone of diabetes management. We conducted a study to evaluate whether specifying the timing of walking in relation to meals enhances the benefits conferred by current physical activity guidelines. METHODS: A total of 41 adults with type 2 diabetes mellitus (mean ± SD age 60 ± 9.9 years; mean diabetes duration 10 years) participated in this randomised, crossover study. Randomisation was by a computer-generated protocol...
October 17, 2016: Diabetologia
https://www.readbyqxmd.com/read/27737895/high-glycated-albumin-and-mortality-in-persons-with-diabetes-mellitus-on-hemodialysis
#13
Christina W Chen, Christiane Drechsler, Pirianthini Suntharalingam, S Ananth Karumanchi, Christoph Wanner, Anders H Berg
BACKGROUND: Monitoring of glycemic control with hemoglobin A1c (A1c) in hemodialysis patients may be compromised by anemia and erythropoietin therapy. Glycated albumin (GA) is an alternative measure of glycemic control but is not commonly used because of insufficient evidence of association to clinical outcomes. We tested whether GA measurements were associated with mortality in hemodialysis patients with diabetes mellitus. METHODS: The German Diabetes and Dialysis Study (4D) investigated effects of atorvastatin on survival in 1255 patients with diabetes mellitus receiving hemodialysis...
October 13, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27727615/comparison-of-glycated-albumin-versus-glycated-haemoglobin-in-diabetic-patients-with-esrd-on-haemodialysis
#14
Megha Reddy, Basanth Kumar
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27720725/glycation-gap-an-additional-tool-for-glycometabolic-monitoring
#15
Renata Paleari, Marta Strollo, Elena Guerra, Ferruccio Ceriotti, Andrea Mosca
BACKGROUND: The determination of glycated albumin (GA) has been suggested as an additional parameter having an independent added value respect to that of HbA1c. The determination of glycation gap (gg) has also been proposed, but few studies have addressed its potential impact in the routine evaluation of glycometabolic control. METHODS: A total of 157 subjects presenting normal whole blood cell count, no hemoglobin variants, normal creatinine levels and serum protein electrophoresis patterns were studied...
December 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27705886/annals-express-alcohol-consumption-reduces-hba1c-and-glycated-albumin-levels-but-not-1-5-anhydroglucitol
#16
Masafumi Koga, Rie Matsumoto
BACKGROUNDS: The effect of alcohol consumption on glycemic control indicators is not well known. In this study, we studied the effect of alcohol consumption on the plasma glucose and glycemic control indicators in non-diabetic men. METHODS: The study enrolled 300 non-diabetic men who received a complete medical checkup [age: 52.8 ± 6.5 years, body mass index (BMI): 24.4 ± 2.8 kg/m(2)]. The subjects were divided into four groups by the amount of alcohol consumed, and the plasma glucose, HbA1c, glycated albumin (GA), and 1,5-anhydroglucitol (1,5-AG) levels of the groups were compared...
October 4, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27686838/ccl18-synergises-with-high-concentrations-of-glucose-in-stimulating-fibronectin-production-in-human-renal-tubuloepithelial-cells
#17
Rosa M Montero, Gurjeet Bhangal, Charles D Pusey, Andrew H Frankel, Frederick W K Tam
BACKGROUND: Diabetic nephropathy is the leading cause of end stage kidney disease worldwide. The pathogenesis of this disease remains elusive and multiple factors have been implicated. These include the effects of hyperglycaemia, haemodynamic and metabolic factors, and an inflammatory process that stimulates cellular signalling pathways leading to disease progression and severe fibrosis. Fibronectin (Fn) is an important protein of the extracellular matrix that is essential in fibrosis and its presence in increased amounts has been identified in the kidney in diabetic nephropathy...
September 29, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27624138/glycated-albumin-identifies-prediabetes-not-detected-by-hemoglobin-a1c-the-africans-in-america-study
#18
Anne E Sumner, Michelle T Duong, Brianna A Bingham, Paola C Aldana, Madia Ricks, Lilian S Mabundo, Marshall K Tulloch-Reid, Stephanie T Chung, David B Sacks
BACKGROUND: Following immigration to the US, many Africans transition from a low-normal to a high-normal or overweight body mass index (BMI). This weight change is associated with a high rate of prediabetes in the nonobese. Studies in East Asians reveal that glycated albumin is effective in identifying prediabetes in nonobese Asians. Whether this is true in African immigrants is unknown. Therefore, we evaluated the ability of hemoglobin A1c (Hb A1c) and glycated albumin to detect prediabetes in nonobese (BMI <30 kg/m(2)) and obese (BMI ≥30 kg/m(2)) African immigrants...
November 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27623968/glycated-albumin-from-biochemistry-and-laboratory-medicine-to-clinical-practice
#19
Elena Dozio, Nicola Di Gaetano, Peter Findeisen, Massimiliano Marco Corsi Romanelli
This review summarizes current knowledge about glycated albumin. We review the changes induced by glycation on the properties of albumin, the pathological implications of high glycated albumin levels, glycated albumin quantification methods, and the use of glycated albumin as a complementary biomarker for diabetes mellitus diagnosis and monitoring and for dealing with long-term complications. The advantages and limits of this biomarker in different clinical settings are also discussed.
September 13, 2016: Endocrine
https://www.readbyqxmd.com/read/27617745/histone-deacetylase-inhibition-restores-retinal-pigment-epithelium-function-in-hyperglycemia
#20
Danielle Desjardins, Yueying Liu, Craig E Crosson, Zsolt Ablonczy
In diabetic individuals, macular edema is a major cause of vision loss. This condition is refractory to insulin therapy and has been attributed to metabolic memory. The retinal pigment epithelium (RPE) is central to maintaining fluid balance in the retina, and this function is compromised by the activation of advanced glycation end-product receptors (RAGE). Here we provide evidence that acute administration of the RAGE agonist, glycated-albumin (gAlb) or vascular endothelial growth factor (VEGF), increased histone deacetylase (HDAC) activity in RPE cells...
2016: PloS One
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