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https://www.readbyqxmd.com/read/28812216/an-overview-of-in-vitro-and-in-vivo-glycation-of-albumin-a-potential-disease-marker-in-diabetes-mellitus
#1
REVIEW
Km Neelofar, Jamal Ahmad
Non-enzymatic glycation of macromolecules, especially proteins leading to their oxidation is increased in diabetes mellitus due to hyperglycaemia and play an important role in associated complications of the disease. Protein glycation mostly occurs in intra chain lysine residues resulting in the formation of early stage Amadori products which are finally converted to advance glycation end products (AGEs). This review deals with the structural studies of in vitro and in vivo glycated human serum albumin (HSA)...
August 15, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28792709/assessment-of-glycated-albumin-as-a-useful-indicator-for-renal-dysfunction-in-diabetic-and-nondiabetic-population
#2
Nan Duan, Sai-Nan Zhu, Hai-Xia Li, Li-Li Jiao, Hong-Yun Yang, Qi Guo
BACKGROUND: Glycated albumin (GA) reflects serum glucose of the preceding 2 - 3 weeks and plays an important role in diabetes mellitus (DM). This study aimed at investigating whether GA can assess renal dysfunction in population. METHODS: 3818 individuals attending physical examination were enrolled in this cross-sectional study and divided into five groups: healthy controls, impaired fasting glucose, DM without renal complications, DM with albuminuria, and nondiabetic chronic kidney disease patients...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28771387/minimizing-glycemic-fluctuations-in-patients-with-type-2-diabetes-approaches-and-importance
#3
Paresh Dandona
Glycemic fluctuations, characterized by short-term oscillations in plasma glucose, are important when managing type 2 diabetes (T2D) and may be considered a target of glucose-lowering therapies. Continuous glucose monitoring (CGM) has been used to evaluate the effects of different treatments on glycemic fluctuations. This review examines approaches to and the importance of minimizing glycemic fluctuations among patients with T2D. Measures of HbA1c, fructosamine, and glycated albumin reflect a long-term average of plasma glucose, and are therefore unable to provide an accurate measure of short-term glycemic oscillations...
August 3, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28719008/comparative-efficacy-and-safety-of-gemigliptin-versus-linagliptin-in-type-2-diabetes-patients-with-renal-impairment-a-40-week-extension-of-the-guard-randomized-study
#4
Sang Youb Han, Sun Ae Yoon, Byoung Geun Han, Sung Gyun Kim, Young-Il Jo, Kyung Hwan Jeong, Kook-Hwan Oh, Hyeong Cheon Park, Sun-Hee Park, Shin-Wook Kang, Ki-Ryang Na, Sun Woo Kang, Nam-Ho Kim, Younghwan Jang, Bogyeong Kim, Seonghye Shin, Dae Ryong Cha
AIMS: The present extension study evaluated the long-term safety and efficacy of gemigliptin during a 40-week follow-up period after a 12-week study. METHODS: The main study was a randomized, placebo-controlled, double-blinded, phase IIIb study in which 50 mg of gemigliptin (N = 66) or placebo (N = 66) was administered to patients with type 2 diabetes mellitus (T2DM) with moderate or severe renal impairment over a 12-week period. Patients with a glycated haemoglobin (HbA1c) level of 7-11% and an estimated glomerular filtration rate (eGFR) of 15-59 mL/min/1...
July 18, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28712850/ex%C3%A2-vivo-instability-of-glycated-albumin-a-role-for-autoxidative-glycation
#5
Joshua W Jeffs, Shadi Ferdosi, Hussein N Yassine, Chad R Borges
Ex vivo protein modifications occur within plasma and serum (P/S) samples due to prolonged exposure to the thawed state-which includes temperatures above -30 °C. Herein, the ex vivo glycation of human serum albumin from healthy and diabetic subjects was monitored in P/S samples stored for hours to months at -80 °C, -20 °C, and room temperature, as well as in samples subjected to multiple freeze-thaw cycles, incubated at different surface area-to-volume ratios or under different atmospheric compositions...
September 1, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28699985/glycated-albumin-a-potential-biomarker-in-diabetes
#6
Priscila Aparecida Correa Freitas, Lethicia Rozales Ehlert, Joíza Lins Camargo
Diabetes mellitus (DM) is a chronic and metabolic disease that presents a high global incidence. Glycated hemoglobin (A1C) is the reference test for long-term glucose monitoring, and it exhibits an association with diabetic chronic complications. However, A1C is not recommended in clinical situations which may interfere with the metabolism of hemoglobin, such as in hemolytic, secondary or iron deficiency anemia, hemoglobinopathies, pregnancy, and uremia. The glycated albumin (GA) is a test that reflects short-term glycemia and is not influenced by situations that falsely alter A1C levels...
May 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28689445/abundance-matters-role-of-albumin-in-diabetes-a-proteomics-perspective
#7
Shweta Bhat, Mashanipalya G Jagadeeshaprasad, Vinashya Venkatasubramani, Mahesh J Kulkarni
Human serum albumin (HSA) is a multifaceted protein with vital physiological functions. It is the most abundant plasma protein with inherent capability to bind to diverse ligands, and thus susceptible to various post-translational modifications (PTMs) which alter its structure and functions. One such PTM is glycation, a non-enzymatic reaction between reducing sugar and protein leading to formation of heterogeneous advanced glycation end products (AGEs). Glycated albumin (GA) concentration increases significantly in diabetes and is implicated in development of secondary complications...
July 13, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28648854/is-there-a-burnt-out-diabetes-phenomenon-in-patients-on-hemodialysis
#8
Masanori Abe, Takayuki Hamano, Junichi Hoshino, Atsushi Wada, Masaaki Inaba, Shigeru Nakai, Ikuto Masakane
AIMS: In patients with diabetes on hemodialysis (HD), glycemic control improves spontaneously, leading to normal glycated hemoglobin (HbA1c) levels; this phenomenon is known as "burnt-out diabetes." However, glycated albumin (GA) might be a better indicator of glycemic control than HbA1c in HD patients. Therefore, the aim of this study was to identify how many patients experience "burnt-out diabetes" using HbA1c and GA levels and to examine the association between cardiovascular comorbidity risk and GA levels...
June 13, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28641154/serum-albumin-adjusted-glycated-albumin-as-a-better-indicator-of-glycemic-control-in-type-2-diabetes-mellitus-patients-with-short-duration-of-hemodialysis
#9
Takahiro Yajima, Kumiko Yajima, Makoto Hayashi, Hiroshi Takahashi, Keigo Yasuda
AIMS: Serum albumin-adjusted glycated albumin (adjusted GA) is reportedly a better predictor of mortality than GA in patients with Type 2 diabetes mellitus (T2DM) on hemodialysis (HD). We compared how accurately GA and adjusted GA reflected glycemic control in these patients. METHODS: We enrolled 31 patients with T2DM on HD. They were divided into two groups according to duration of HD: ≤6months (short HD group, N=16) and >6months (long HD group, N=15). GA or adjusted GA and parameters of glycemic control obtained by continuous glucose monitoring were measured, and the correlations between these were analyzed...
June 9, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28605777/racial-differences-in-the-relationship-of-glucose-concentrations-and-hemoglobin-a1c-levels
#10
MULTICENTER STUDY
Richard M Bergenstal, Robin L Gal, Crystal G Connor, Rose Gubitosi-Klug, Davida Kruger, Beth A Olson, Steven M Willi, Grazia Aleppo, Ruth S Weinstock, Jamie Wood, Michael Rickels, Linda A DiMeglio, Kathleen E Bethin, Santica Marcovina, Andreana Tassopoulos, Sooji Lee, Elaine Massaro, Suzan Bzdick, Brian Ichihara, Eileen Markmann, Paul McGuigan, Stephanie Woerner, Michelle Ecker, Roy W Beck
Background: Debate exists as to whether the higher hemoglobin A1c (HbA1c) levels observed in black persons than in white persons are due to worse glycemic control or racial differences in the glycation of hemoglobin. Objective: To determine whether a racial difference exists in the relationship of mean glucose and HbA1c. Design: Prospective, 12-week observational study. Setting: 10 diabetes centers in the United States...
July 18, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28605542/alternative-measures-of-hyperglycemia-and-risk-of-alzheimer-s-disease-in-the-community-the-hisayama-study
#11
Naoko Mukai, Tomoyuki Ohara, Jun Hata, Yoichiro Hirakawa, Daigo Yoshida, Hiro Kishimoto, Masafumi Koga, Udai Nakamura, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya
Context and Objective: We investigated the associations of hemoglobin A1c (HbA1c), glycated albumin (GA), the GA/HbA1c ratio, and 1,5-anhydroglucitol (1,5-AG) with the development of Alzheimer's disease (AD) in community-dwelling Japanese subjects. Design and Participants: A total of 1,187 subjects aged ≥65 years without dementia were followed up for an average of 4.8 years. Results: During the follow-up, 116 subjects experienced AD. The age- and sex-adjusted incidence of AD increased significantly with higher quartiles of the GA/HbA1c ratio, and a similar tendency was seen for GA, while no such association was observed for HbA1c and 1,5-AG...
June 9, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28589381/the-diagnostic-value-of-glycated-albumin-in-gestational-diabetes-mellitus
#12
Jieping Zhu, Yu Chen, Changbin Li, Minfang Tao, Yincheng Teng
PURPOSE: Our objective was to compare the diagnostic performance of glycated hemoglobin (HbA1c), GA, and fasting plasma glucose (FPG) for the diagnosis of GDM. METHODS: Women at their late second or early third trimesters seen from October 2011 to April 2012 were studied. GDM was diagnosed based on oral glucose tolerance test results, and GA and HbA1c were measured at the same time. Patients were divided into two groups (with and without GDM), and areas under the receiver-operating characteristic curves (AUCs) were calculated to determine the diagnostic value of FPG, GA, and HbA1c...
June 6, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28586301/definition-of-the-upper-reference-limit-of-glycated-albumin-in-blood-donors-from-italy
#13
Chiara Bellia, Martina Zaninotto, Chiara Cosma, Luisa Agnello, Bruna Lo Sasso, Giulia Bivona, Mario Plebani, Marcello Ciaccio
BACKGROUND: Glycated Albumin (GA) has been proposed as a short-term indicator of glycemic homeostasis. The aim of this study is to describe the distribution of GA in a large sample of blood donors from Italy to evaluate whether demographic features, namely age and sex, could influence GA levels and define specific reference limits. METHODS: The study included 1334 Italian blood donors. GA was measured using an enzymatic method (quantILab Glycated Albumin, IL Werfen, Germany)...
June 6, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28556931/quantification-of-carbamylated-albumin-in-serum-based-on-capillary-electrophoresis
#14
Sigurd Delanghe, Alena Moerman, Anneleen Pletinck, Eva Schepers, Griet Glorieux, Wim Van Biesen, Joris R Delanghe, Marijn M Speeckaert
Protein carbamylation, a nonenzymatic posttranslational modification promoted during uremia, is linked to a poor prognosis. In the present study, carbamylation of serum albumin was assayed using the symmetry factor on a capillary electrophoresis instrument (Helena V8). The symmetry factor has been defined as the distance from the center line of the peak to the back slope, divided by the distance from the center line of the peak to the front slope, with all measurements made at 10% of the maximum peak height...
May 30, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28538363/the-effect-of-alpha-linolenic-acid-on-glycemic-control-in-individuals-with-type-2-diabetes-a-systematic-review-and-meta-analysis-of-randomized-controlled-clinical-trials
#15
REVIEW
Elena Jovanovski, Dandan Li, Hoang Vi Thanh Ho, Vladimir Djedovic, Any de Castro Ruiz Marques, Esra Shishtar, Sonia Blanco Mejia, John L Sievenpiper, Russell J de Souza, Lea Duvnjak, Vladimir Vuksan
BACKGROUND: Polyunsaturated fats (PUFAs) have been shown to reduce type 2 diabetes (T2DM) risk and improve insulin responsiveness in T2DM subjects, but whether the plant sources of omega-3 PUFA (alpha-linolenic acid [ALA]) have an effect on glycemic control requires further investigation. METHODS: The parameters of interest were glycated hemoglobin (HbA1c), fasting blood glucose (FBG), fasting blood insulin (FBI), homeostatic model assessment for insulin resistance (HOMA-IR), fructosamine, and glycated albumin...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28535187/serum-levels-of-1-5-anhydroglucitol-and-risk-of-incident-end-stage-renal-disease
#16
Casey M Rebholz, Morgan E Grams, Yuan Chen, Alden L Gross, Yingying Sang, Josef Coresh, Elizabeth Selvin
Glycemic excursions, independent of average glucose, have been implicated in the development of diabetic implications. It is unknown if low 1,5-anyhydroglucitol (1,5-AG) are associated with advanced stages of kidney disease independent of kidney function and glycemia. In the Atherosclerosis Risk in Communities Study (N = 13,277), we used structural equation modeling to estimate the association between serum 1,5-AG levels and end-stage renal disease from baseline (1990-1992) through 2013 with adjustment for demographics, risk factors, a latent variable for glycemia (diabetes status, fasting glucose, hemoglobin A1c, fructosamine, glycated albumin), and a latent variable for kidney function (creatinine, cystatin C, β2-microglobulin)...
May 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28532193/glycated-albumin-level-during-late-pregnancy-as-a-predictive-factor-for-neonatal-outcomes-of-women-with-diabetes
#17
Daisuke Sugawara, Atsuko Kawano, Kohei Nagai, Hiroaki Sato, Ko Ichihashi
PURPOSE: To investigate the association between glycated albumin (GA) in diabetic mothers and complications in their children, and determine GA cut-off values for predicting complications in infants. MATERIALS AND METHODS: This hospital-based case-control study involved 71 Japanese diabetic mothers and their children. Mean GA values were compared between mothers of infants with and without complications, and relationship with number of complications was analyzed by Pearson's correlation...
May 22, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28513427/population-pharmacokinetics-of-lyophilized-recombinant-glucagon-like-peptide-1-receptor-agonist-recombinant-exendin-4-re-4-in-chinese-patients-with-type-2-diabetes-mellitus%C3%A2
#18
Yan-Nan Zang, Min-Jie Zhang, Yi-Tong Wang, Chen Wang, Qian Wang, Qing-Shan Zheng, Li-Nong Ji, Wei Guo, Yi Fang
OBJECTIVE: To investigate the population pharmacokinetics of lyophilized recombinant glucagon-like peptide-1 receptor agonist (rE-4) in Chinese patients with type 2 diabetes mellitus (T2DM) for plasma concentration estimation and individualized treatment. METHODS: Twelve patients with T2DM were enrolled to receive subcutaneous injections of rE-4 at 5 µg twice daily for 84 days. Administration dosage was adjusted from 5 µg to 10 µg twice daily at day 29 in case of glycated albumin (GA) ≥ 17%...
May 17, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28504612/changes-in-the-albumin-glycation-site-plasma-pentosidine-and-esrage-concentrations-before-and-after-intensive-diabetic-treatment-in-patients-with-abnormally-high-glycated-albumin-levels
#19
Hiroyasu Miyamoto, Takuji Kohzuma, Akihiro Ohnishi
Background We have reported that the blood glucose normalization treatment reduced the albumin glycation sites and the intensity of albumin AGE fluorescence in patients with abnormally high glycated albumin levels. To clarify the relationship between glycaemic control status and levels of glycated proteins and related markers, we studied the change of the markers of the DM patients with and without fatty liver, liver cirrhosis and dialysis before and after the intensive diabetic treatment. Methods Eight diabetic patients with abnormally high glycated albumin levels (no complications: 2, fatty liver: 3, liver cirrhosis: 2, dialysis: 1) were recruited...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28487124/concordance-the-hemoglobin-glycation-index-with-glycation-gap-using-glycated-albumin-in-patients-with-type-2-diabetes
#20
Mee Kyoung Kim, Jee Sun Jeong, Hyuk-Sang Kwon, Ki Hyun Baek, Ki-Ho Song
BACKGROUND: The hemoglobin glycation index (HGI) is an index of differences in the glycation of hemoglobin according to blood glucose level. The glycation gap (G-gap) is an empiric measure of the extent of disagreement between hemoglobin A1C (HbA1C) and glycated albumin (GA). The aim of this study was to investigate the extent of agreement between the HGI and G-gap with respect to GA level, and to elucidate factors related to a high HGI. METHOD: Data were obtained from 105 patients with type 2 diabetes, and fasting blood glucose (FBG), HbA1c, and GA values were measured simultaneously...
April 18, 2017: Journal of Diabetes and its Complications
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