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"Glycated albumin"

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https://www.readbyqxmd.com/read/28074608/aged-garlic-extract-suppresses-the-increase-of-plasma-glycated-albumin-level-and-enhances-the-amp-activated-protein-kinase-in-adipose-tissue-in-tsod-mice
#1
Satomi Miki, Ken-Ichi Inokuma, Miyuki Takashima, Mitsuho Nishida, Yoko Sasaki, Mitsuyasu Ushijima, Jun-Ichiro Suzuki, Naoaki Morihara
SCOPE: In this study, we investigated the effect of aged garlic extract (AGE) on the high level of blood glucose in Tsumura Suzuki Obese-Diabetes (TSOD) mice. METHODS AND RESULTS: TSOD mice were fed standard diet with or without 2% AGE for 19 weeks. AGE treatment lowered the blood glucose level and significantly reduced the plasma level of glycated albumin in TSOD mice as compared with those without AGE treatment. In addition, AGE treatment increased the level of phosphorylated AMP-activated protein kinase (AMPK) in the adipose tissue, liver and muscle that played an important role in the maintenance of insulin sensitivity...
January 11, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28067098/glycated-albumin-modifies-platelet-adhesion-and-aggregation-responses
#2
Ioana Soaita, Wei Yin, David A Rubenstein
A diabetic vasculature is detrimental to cardiovascular health through the actions of advanced glycation end products (AGEs) on endothelial cells and platelets. Platelets activated by AGEs agonize endothelial responses promoting cardiovascular disease (CVD) development. While it has been established that AGEs can alter platelet functions, little is known about the specific platelet pathways that AGEs modify. Therefore, we evaluated the effects of AGEs on specific salient platelet pathways related to CVDs and whether the effects that AGEs elicit are dependent on glycation extent...
January 9, 2017: Platelets
https://www.readbyqxmd.com/read/28019072/efficacy-safety-and-albuminuria-reducing-effect-of-gemigliptin-in-korean-type-2-diabetes-patients-with-moderate-to-severe-renal-impairment-a-12-week-double-blind-randomized-study-the-guard-study
#3
Sun A Yoon, Byoung G Han, Sung G Kim, Sang Y Han, Young I Jo, Kyung H Jeong, Kook H Oh, Hyoung C Park, Sun H Park, Shin W Kang, Ki R Na, Sun W Kang, Nam H Kim, Young H Jang, Seong H Shin, Dae R Cha
AIMS: This multicentre, randomized, double-blind study investigated the efficacy and safety of gemigliptin in Korean type 2 diabetes mellitus (T2DM) patients with moderate to severe renal impairment (RI). METHODS: The study comprised a 12-week main part and a 40-week extension. We report the results from the main part. In total, 132 patients were randomized to receive gemigliptin (n = 66) or placebo (n = 66). Changes in glycated haemoglobin (HbA1c; primary endpoint), other glycaemic control parameters (fasting plasma glucose, glycated albumin, and fructosamine), lipid profiles, renal function parameters, and safety profiles were evaluated...
December 25, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28005306/non-enzymatic-glycation-interferes-with-fibronectin-integrin-interactions-in-vascular-smooth-muscle-cells
#4
Srijita Dhar, Zhe Sun, Gerald A Meininger, Michael A Hill
OBJECTIVE: We aimed to investigate whether advanced non-enzymatic glycation of the extracellular matrix (ECM) protein, fibronectin, impacts its normal integrin-mediated interaction with arteriolar vascular smooth muscle cells (VSMC). METHODS: Atomic force microscopy (AFM) was performed on cultured VSMC from rat cremaster arterioles to study native and glycated fibronectin (FN and gFN) interactions with cellular integrins. AFM probes were functionalized with FN or gFN or with native or glycated albumin (gAlb) as controls...
December 22, 2016: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28004067/-advanced-glycated-albumin-induces-macrophage-apoptosis-via-activating-caspase-12-pathway
#5
Jin-Guo Li, Qi Hao, Ying-Xue Liu, Peng Li, Peng Li, Xia-Yan Shao, Hua Tian, Yong-Qi Fang, Shu-Tong Yao
The purpose of the present study was to investigate the effect of advanced glycated albumin (AGE-alb) on the activation of caspase-12, a key molecule in endoplasmic reticulum stress (ERS)-associated apoptotic pathway, and to elucidate the underlying molecular mechanisms of macrophage apoptosis. RAW264.7 macrophages were treated with AGE-alb (2, 4 and 6 g/L), control albumin (C-alb, 4 g/L), tunicamycin (TM, 4 mg/L), or pretreated with 4-phenylbutyric acid (PBA, 5 mmol/L) for 1 h and then treated with AGE-alb (4 g/L)...
December 25, 2016: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/27995726/glycemic-control-indicator-levels-at-diagnosis-of-neonatal-diabetes-mellitus-comparison-with-other-types-of-insulin-dependent-diabetes-mellitus
#6
Shigeru Suzuki, Akiko Furuya, Yusuke Tanahashi, Hiroshi Azuma, Yukihiro Bando, Soji Kasayama, Masafumi Koga
BACKGROUND: Neonatal diabetes mellitus (NDM) is a monogenic insulin-dependent diabetes that develops within 6 months of age. The progression of hyperglycemia until diagnosis is unknown. Glycemic control indicators at diagnosis are useful to estimate the extent and duration of hyperglycemia. We recently established that age-adjusted glycated albumin (GA) is a useful indicator of glycemic control, regardless of age. OBJECTIVE: To compare the levels of various glycemic control indicators at diagnosis between NDM and other types of insulin-dependent diabetes mellitus...
December 20, 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/27933186/effect-of-type-and-amount-of-dietary-carbohydrate-on-biomarkers-of-glucose-homeostasis-and-c-reactive-protein-in-overweight-or-obese-adults-results-from-the-omnicarb-trial
#7
Stephen P Juraschek, Edgar R Miller, Elizabeth Selvin, Vincent J Carey, Lawrence J Appel, Robert H Christenson, Frank M Sacks
OBJECTIVE: The glycemic index (GI) of dietary carbohydrate is thought to affect glucose homeostasis. Recently, the Effect of Amount and Type of Dietary Carbohydrates on Risk for Cardiovascular Heart Disease and Diabetes Study (OmniCarb) trial reported that a low-GI diet did not improve insulin sensitivity. We conducted this ancillary study of the OmniCarb trial to determine the effects of GI and carbohydrate content on glucose homeostasis and inflammation. RESEARCH DESIGN AND METHODS: OmniCarb was a randomized cross-over feeding study conducted in overweight or obese adults without diabetes (N=163)...
2016: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/27923630/association-of-glycated-albumin-to-hba1c-ratio-with-diabetic-retinopathy-but-not-diabetic-nephropathy-in-patients-with-type-2-diabetes
#8
Yutaka Umayahara, Yohei Fujita, Hirotaka Watanabe, Noriko Kasai, Noritaka Fujiki, Masahiro Hatazaki, Masafumi Koga
OBJECTIVES: The ratio of glycated albumin to HbA1c (GA/HbA1c ratio) is a known indicator that reflects fluctuations in plasma glucose. In this study, the association of the GA/HbA1c ratio to diabetic nephropathy and diabetic retinopathy in patients with type 2 diabetes was investigated. DESIGN AND METHODS: Among patients with type 2 diabetes, 613 patients (364 males and 249 females, aged 63.2±12.5, body mass index (BMI) 25.4±4.8kg/m(2)) were enrolled. Patients with overt proteinuria, reduced renal function, or anemia were excluded...
December 5, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27896233/serum-fructosamine-serum-glycated-albumin-and-serum-glycated-%C3%AE-lipoprotein-in-type-2-diabetes-mellitus-patients-with-and-without-microvascular-complications
#9
Tejaskumar R Kalaria, Habibunnisha B Sirajwala, Mukesh G Gohel
BACKGROUND: Glycation of serum proteins has been proposed as an important mechanism of complications of diabetes but whether there are differences in glycation of different serum proteins and whether it has any correlation with development of microvascular complications has not been studied in depth. This study aimed to assess level of serum fructosamine, glycated albumin and glycated β-lipoprotein in type 2 diabetes mellitus patients with and without microvascular complications and to find out their correlation with diabetes complications...
2016: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/27890722/diabetes-induced-hepatic-oxidative-stress-a-new-pathogenic-role-for-glycated-albumin
#10
Jessica Patche, Dorothée Girard, Aurélie Catan, Florence Boyer, Anthony Dobi, Cynthia Planesse, Nicolas Diotel, Alexis Guerin-Dubourg, Pascal Baret, Susana B Bravo, Beatriz Paradela-Dobarro, Ezequiel Álvarez, M Faadiel Essop, Olivier Meilhac, Emmanuel Bourdon, Philippe Rondeau
Increased oxidative stress and advanced glycation end-product (AGE) formation are major contributors to the development of type 2 diabetes. Here plasma proteins e.g. albumin can undergo glycoxidation and play a key role in diabetes onset and related pathologies. However, despite recent progress linking albumin-AGE to increased oxidative stress and downstream effects, its action in metabolic organs such as the liver remains to be elucidated. The current study therefore investigated links between oxidative perturbations and biochemical/structural modifications of plasma albumin, and subsequent downstream effects in transgenic db/db mouse livers and HepG2 cells, respectively...
January 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27873436/alternate-glycemic-markers-reflect-glycemic-variability-in-continuous-glucose-monitoring-in-youth-with-prediabetes-and-type-2-diabetes
#11
Christine L Chan, Laura Pyle, Megan M Kelsey, Lindsey Newnes, Amy Baumgartner, Philip S Zeitler, Kristen J Nadeau
OBJECTIVE: To determine whether the alternate glycemic markers, fructosamine (FA), glycated albumin (GA), and 1,5-anhydroglucitol (1,5AG), predict glycemic variability captured by continuous glucose monitoring (CGM) in obese youth with prediabetes and type 2 diabetes (T2D). STUDY DESIGN: Youth with BMI ≥85th%ile, 10-18 years, had collection of fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), FA, GA, and 1,5AG and 72 hours of CGM. Participants with HbA1c ≥5...
November 22, 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/27859632/the-establishment-of-biological-reference-intervals-of-nontraditional-glycemic-markers-in-a-chinese-population
#12
Qiang Zhou, De-Bao Shi, Li-Ying Lv
BACKGROUND: We established the reference intervals for glycated albumin (GA), fructosamine (FA), and 1,5-anhydroglucitol (1,5-AG) in a Chinese healthy population. METHODS: This study enrolled a total of 458 eligible reference individuals, consisted of 226 men and 232 women, aged from 20~79 years (median age 43 years), who attending routine healthy checks. We stratified the subjects according to gender (males and females) and age (20-39, 40-59, and 60-79 years), and combined statistical methods with Lahti algorithm, as well as appropriate clinical consideration, to judge whether partitioning for data was needed...
November 17, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27843494/changes-in-antidiabetic-prescription-patterns-and-indicators-of-diabetic-control-among-200-000-patients-over-13%C3%A2-years-at-a-single-institution-in-japan
#13
Kazutoshi Fujibayashi, Michio Hayashi, Hirohide Yokokawa, Toshio Naito
BACKGROUND: We examined the long-term changes in the management of diabetes at a single institution in Japan. METHODS: Two repeated cross-sectional studies and a retrospective cohort study were conducted among patients who visited our institution between 2001 and 2013. We examined the changes in glycated hemoglobin (HbA1c) and glycated albumin levels, the prescription frequencies, and the daily doses of each antidiabetic agent among patients treated regularly for diabetes during the 13-year study period...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27830830/ethnic-differences-in-glucose-homeostasis-markers-between-the-kyushu-okinawa-population-study-and-the-framingham-offspring-study
#14
Hiroaki Ikezaki, Masumi Ai, Ernst J Schaefer, Seiko Otokozawa, Bela F Asztalos, Katsuyuki Nakajima, Yanhua Zhou, Ching-Ti Liu, Paul F Jacques, L Adrienne Cupples, Norihiro Furusyo
We compared markers of glucose homeostasis and their association with diabetes and impaired fasting glucose (IFG) in Fukuoka, Japanese subjects (n = 1108) and age-, gender- and menopausal status-matched participants in the Framingham Offspring Study (n = 1096). The markers examined included fasting glucose, insulin, adiponectin, and glycated albumin, as well as body mass index (BMI), use of medications, and history of diabetes. The results showed that IFG prevalence in Japanese men (15.9%) and women (7...
November 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27829338/electrochemical-biosensor-for-detection-of-glycated-albumin
#15
Edyta Mikuła, Aleksandra Wysłouch-Cieszyńska, Liliya Zhukova, Peter Verwilst, Wim Dehaen, Jerzy Radecki, Hanna Radecka
This paper presents an electrochemical biosensor based on a thiol derivative of a pentetic acid (DPTA) complex with Cu (II) created on a gold electrode surface. His-tagged domains of Receptors for Advanced Glycation End Products (RAGE) have been applied as an analytical active element for the determination of the glycated albumin. DPTA-Cu(II) complex molecules play a double role. They are sites for covalent immobilization of His6- RAGE domains, as well as transducers of the analytical signal. The binding of glycated albumin by His6- RAGE domains causes a variation in the electrochemical properties of the Cu(II) redox centers tethered to the electrode surface...
November 8, 2016: Current Alzheimer Research
https://www.readbyqxmd.com/read/27775182/glycated-albumin-is-associated-with-body-mass-index-in-euglycemic-adults-but-is-not-predictive-of-postprandial-blood-glucose-response
#16
Andrew N Reynolds, Ashley Duncan, Devonia Kruimer, Bernard J Venn
BACKGROUND: The level of glycated albumin in circulation is an indicator of blood glucose control over the preceding 2 weeks. It is not known if the level of glycated albumin in circulation relates to an individual's postprandial blood glucose response. METHODS: Eighty-four euglycemic young adults (21.1 [3.9] years, BMI 23.9 [4.0] kg/m(2) ) primarily of European descent underwent a fasted meal test of 50 g carbohydrate from white bread. Capillary blood was then sampled at regular intervals over 2 hours...
October 24, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27773732/chicken-albumin-exhibits-natural-resistance-to-glycation
#17
Jessica Zuck, Chad R Borges, Eldon J Braun, Karen L Sweazea
Glycation of proteins and subsequent production of advanced glycation end products (AGEs) is a major contributor to the pathophysiology of diabetes. The objective of the present study was to compare the glycation of avian and human serum albumin to elucidate the mechanisms by which protein glycation in birds is prevented in the presence of naturally high plasma glucose concentrations. Solutions of purified chicken and human serum albumin (CSA and HSA) were prepared with four different glucose concentrations (0, 5...
January 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/27747394/advice-to-walk-after-meals-is-more-effective-for-lowering-postprandial-glycaemia-in-type-2-diabetes-mellitus-than-advice-that-does-not-specify-timing-a-randomised-crossover-study
#18
Andrew N Reynolds, Jim I Mann, Sheila Williams, Bernard J Venn
AIMS/HYPOTHESIS: Regular physical activity is a cornerstone of diabetes management. We conducted a study to evaluate whether specifying the timing of walking in relation to meals enhances the benefits conferred by current physical activity guidelines. METHODS: A total of 41 adults with type 2 diabetes mellitus (mean ± SD age 60 ± 9.9 years; mean diabetes duration 10 years) participated in this randomised, crossover study. Randomisation was by a computer-generated protocol...
October 17, 2016: Diabetologia
https://www.readbyqxmd.com/read/27737895/high-glycated-albumin-and-mortality-in-persons-with-diabetes-mellitus-on-hemodialysis
#19
Christina W Chen, Christiane Drechsler, Pirianthini Suntharalingam, S Ananth Karumanchi, Christoph Wanner, Anders H Berg
BACKGROUND: Monitoring of glycemic control with hemoglobin A1c (A1c) in hemodialysis patients may be compromised by anemia and erythropoietin therapy. Glycated albumin (GA) is an alternative measure of glycemic control but is not commonly used because of insufficient evidence of association to clinical outcomes. We tested whether GA measurements were associated with mortality in hemodialysis patients with diabetes mellitus. METHODS: The German Diabetes and Dialysis Study (4D) investigated effects of atorvastatin on survival in 1255 patients with diabetes mellitus receiving hemodialysis...
October 13, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27727615/comparison-of-glycated-albumin-versus-glycated-haemoglobin-in-diabetic-patients-with-esrd-on-haemodialysis
#20
Megha Reddy, Basanth Kumar
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
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