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Antoni Sicras-Mainar, Ruth Navarro-Artieda, Raúl Morano, Lucía Ruíz
OBJECTIVES: The main objective was to assess resource use and costs of starting treatment with insulin or injectable GLP-1 receptor analogues (GLP-1 RAs) in a Spanish population of patients with type 2 diabetes mellitus. Treatment adherence and persistence were also determined for both treatment groups. PATIENTS AND METHODS: A retrospective, non-interventional, observational study was conducted. Patients aged ≥20 years who started treatment with insulin or GLP-1 RAs in the 2010-2012 period were recruited...
October 13, 2016: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
Naoto Takahashi
BCR-ABL tyrosine kinase inhibitor (TKI) has dramatically improved the prognosis of CML patients. Now, one of the most important factors with a marked effect on prognosis in CML patients is having a comorbidity. Recently, cardiovascular events (CVE) have been reported in some clinical trials as a late toxicity of TKI, which might be associated with off-target of TKI, ABL/ARG, PDGFR and VEGFR. Because TKI-associated CVE is one of the potentially lethal adverse events associated with TKI administration, hematologists must practice the "ABCDE steps" for CML patients treated with second generation TKI in collaboration with cardiologists...
2016: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Edith Heintjes, Josephina Kuiper, Bianca Lucius, Fernie Penning-van Beest, Lucie Kutikova, Anho Liem, Ron Herings
OBJECTIVE: To describe clinical characteristics and cholesterol management of patients with cardiovascular events (CVEs) and/or type 2 diabetes mellitus (T2DM) with high low-density lipoprotein cholesterol (LDL-C) > 1.8 mmol/L in the Netherlands. RESEARCH DESIGN AND METHODS: From the PHARMO Database Network a cross-sectional cohort was constructed. The descriptive study included patients on lipid modifying therapy (LMT) in 2009, classified as high cardiovascular risk based on a history of T2DM or CVE, with 2010 LDL-C levels above 1...
September 29, 2016: Current Medical Research and Opinion
Sadayoshi Ito
SPRINT is one of the landmark studies, demonstrating that extensive blood pressure (BP) control (BP < 120 mmHg) is superior to standard control (BP < 140 mmHg) in preventing cardiovascular event (CVE). Subjects recruited were older than 50 years without diabetes and had increased risk of CVE. Heart failure, death from cardiovascular cause and death from any cause were major endpoints reduced by extensive BP control. In subgroup analysis, whole spectrum of patients were benefitted. Contrary to several previous studies, this study provides strong evidence for the beneficial effect of extensive BP reduction...
September 2016: Journal of Hypertension
Matheus Simonato, Ali N Azadani, John Webb, Jonathon Leipsic, Ran Kornowski, Alec Vahanian, David Wood, Nicolo Piazza, Susheel Kodali, Jian Ye, Brian Whisenant, Diego Gaia, Mina Aziz, Tilak Pasala, Julinda Mehilli, Harindra C Wijeysundera, Didier Tchetche, Neil Moat, Rui Teles, Anna Sonia Petronio, David Hildick-Smith, Uri Landes, Stephan Windecker, Yaron Arbel, Oscar Mendiz, Raj Makkar, Elaine Tseng, Danny Dvir
AIMS: Transcatheter heart valve (THV) implantation in failed bioprosthetic valves (valve-in-valve [ViV]) offers an alternative therapy for high-risk patients. Elevated post-procedural gradients are a significant limitation of aortic ViV. Our objective was to assess the relationship between depth of implantation and haemodynamics. METHODS AND RESULTS: Commercially available THVs used for ViV were included in the analysis (CoreValve Evolut, SAPIEN XT and the Portico valve)...
September 18, 2016: EuroIntervention
Yu Kataoka, Rishi Puri, Anthony D Pisaniello, Muhammad Hammadah, Mohammed Qintar, Kiyoko Uno, Joseph K Montarello, Stephen J Nicholls, Stephen G Worthley
AIMS: Embolisation of atheromatous debris during catheter manipulation is considered to underlie acute cerebrovascular events (CVE) after transcatheter aortic valve implantation (TAVI). However, the relationship between aorta atheroma burden and acute CVE after TAVI has not been established. We investigated the impact of aorta atheroma burden on acute CVE. METHODS AND RESULTS: Preoperative multislice computed tomographic (MSCT) images in 278 patients receiving TAVI were analysed...
August 20, 2016: EuroIntervention
Vincent Lak, Ann-Marie Svensson, Mervete Miftaraj, Stefan Franzén, Björn Eliasson
INTRODUCTION: Studies comparing direct-acting insulin analogs (DAIs) in terms of effectiveness and long-term safety are scarce. Our aim was to explore these variables in clinical practice among patients with type 1 diabetes, including the elderly and those with renal impairment. METHODS: We linked four national registers in a population-based cohort study. Patients with type 1 diabetes and continuous use of all currently available DAIs (lispro, aspart, or glulisine) in 2005-2013 were monitored for up to 7...
September 2016: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Vincent Auffret, Ander Regueiro, María Del Trigo, Omar Abdul-Jawad Altisent, Francisco Campelo-Parada, Olivier Chiche, Rishi Puri, Josep Rodés-Cabau
BACKGROUND: Identifying transcatheter aortic valve replacement (TAVR) patients at high risk for cerebrovascular events (CVE) is of major clinical relevance. However, predictors have varied across studies. OBJECTIVES: The purpose of this study was to analyze the predictors of 30-day CVE post-TAVR. METHODS: A systematic review of studies that reported the incidence of CVE post-TAVR while providing raw data for predictors of interest was performed...
August 16, 2016: Journal of the American College of Cardiology
L Mos, C Fania, F Saladini, A Mazzer, S Cozzio, A Bortolazzi, G Garavelli, E Casiglia, P Palatini
OBJECTIVE: Coffee consumption has been found to predict the risk of cardiovascular events (CVE) in hypertension. Aim of the present study was to ascertain whether the strength of the coffee-CVE association is modulated by regular physical activity. DESIGN AND METHOD: The analysis was made in 1204 participants from the HARVEST, a prospective cohort study of non-diabetic subjects aged 18-45 years, screened for stage 1 hypertension. Among the participants, 26.2% were abstainers, 62...
September 2016: Journal of Hypertension
P Palatini, P Reboldi, S Pierdomenico, K Eguchi, K Kario, Y Imai, T Ohkubo, L Beilin, L Wing, J Schwartz, E Casiglia, P Verdecchia
OBJECTIVE: Heart rate (HR) is a well known predictor of cardiovascular events (CVE) and mortality but the relative role of resting office HR and ambulatory HR for predicting these outcomes is not well known. Aim of this study was to investigate the association of white-coat tachycardia and masked tachycardia with CVE and all-cause mortality in hypertensive subjects. DESIGN AND METHOD: We performed 24-hour ambulatory blood pressure and HR monitoring in 7602 hypertensive patients (4165 men) aged 52 ± 16 years enrolled in 8 prospective studies in Italy, U...
September 2016: Journal of Hypertension
A Cremer, R Boulestreau, P Gosse
OBJECTIVE: Hypertension still remains the main cardiovascular risk factor. Given its high prevalence, identification of patients with the higher risk of facing a cardiovascular event (CVE) is matter of concern. Several tools have been proposed. In particular ambulatory blood pressure (BP) measurement has proven its superiority to office BP but other parameters like arterial stiffness measurement as well as central BP may contribute to a better risk level assessment. To date, there is no data about the potential interest of 24-H non invasive central BP recording for CVE prediction...
September 2016: Journal of Hypertension
Mehmet Kanbay, Yalcin Solak, Dimitrie Siriopol, Gamze Aslan, Baris Afsar, Dilek Yazici, Adrian Covic
BACKGROUND AND AIM: Chronic kidney disease mineral and bone disorder (CKD-MBD) is associated with increased morbidity and mortality. Several cross-sectional studies investigated the association of serum sclerostin levels with mortality and vascular calcification. We aimed to investigate the effect of sclerostin on cardiovascular events (CVE), all-cause/cardiovascular mortality and vascular calcification in patients with CKD through systematic review and meta-analysis. The primary outcome was the association between sclerostin level and development of fatal and nonfatal CVE and all-cause mortality...
August 6, 2016: International Urology and Nephrology
T V Popkova, D S Novikova, E L Nasonov
Rheumatoid arthritis (RA) is a' disease conferring high risk for cardiovascular events (CVE). Systemic inflammation underlying RA favors development of CVE. The safety of biological agents, acting on the cardiovascular system has been inadequately investigated. On the one hand, they decrease RA activity and, on the other, may increase the risk of CVE. This review analyzes' the literature data predominantly published in recent years on the effect of an IL-6 receptor inhibitor on the cardiovascular system. Tocilizumab is shown to be a promising agent to reduce cardiovascular risk the findings need to be clinically verified...
2016: Terapevticheskiĭ Arkhiv
Islam Sharabas, Nauman Siddiqi
This study was performed to assess the cardiovascular disease (CVD) risk factors in the prevalent peritoneal dialysis (PD) and hemodialysis (HD) patients and their association with cardiovascular events (CVEs) in a Saudi end-stage renal disease cohort. This was a prospective, observational, single-center study. A total of 192 patients were screened of which 157 patients were eligible (HD = 121, PD = 36). All patients underwent assessment of cardiovascular risk factors at the time of enrollment including electrocardiogram and echocardiography, lipid profile, homocysteine, and insulin levels...
July 2016: Saudi Journal of Kidney Diseases and Transplantation
Mehmet Kanbay, Baris Afsar, Dimitrie Siriopol, Hilmi Umut Unal, Murat Karaman, Mutlu Saglam, Mustafa Gezer, Ahmet Taş, Tayfun Eyileten, Ahmet Kerem Guler, İbrahim Aydin, Yusuf Oguz, Kayhan Tarim, Adrian Covic, Mahmut Ilker Yilmaz
BACKGROUND AND AIMS: Endostatin, generated from collagen XVIII, and endorepellin, possess dual activity as modifiers of both angiogenesis and endothelial cell autophagy. Plasma endostatin levels are elevated in a large number of diseases, and may reflect endothelial cell dysfunction. Few data on endostatins are available for patients with chronic kidney disease (CKD). We tested whether serum endostatin values are predictive for all-cause mortality and cardiovascular events (CVEs) in a CKD population...
September 2016: European Journal of Internal Medicine
Tomo Ando, Alexandros Briasoulis, Anthony A Holmes, Cynthia C Taub, Hisato Takagi, Luis Afonso
OBJECTIVES: The S3 prosthetic valve was introduced to overcome several issues with its predecessor, the SXT, in transcatheter aortic valve implantation (TAVI), however, the clinical outcomes of this new model are not clearly defined. We performed a meta-analysis to compare the outcomes in Sapien 3 (S3) and Sapien XT (SXT) recipients. METHODS: A literature search through PUBMED and EMBASE was conducted. Articles that included at least one of the clinical outcomes of interest were included in the meta-analysis: moderate to severe paravalvular regurgitation (PVR), permanent pacemaker implantation (PPI), major vascular complications (MVC), cerebrovascular events (stroke and transient ischemic attack) (CVE), failure rate of device implantation, life-threatening, disabling or major bleeding, need for post-dilation and early all-cause-mortality...
October 1, 2016: International Journal of Cardiology
Sandip Chaugai, Lhamo Yanchang Sherpa, Amir A Sepehry, Hisatomi Arima, Dao Wen Wang
Recent studies have demonstrated that atrial fibrillation significantly increases the risk of adverse clinical outcomes in high cardiovascular disease risk subjects. Application of renin-angiotensin-aldosterone system blockers for prevention of recurrence of atrial fibrillation and adverse clinical outcomes in subjects with atrial fibrillation is a theoretically appealing concept. However, results of clinical trials evaluating the effect of renin-angiotensin-aldosterone blockers on adverse clinical outcomes in high cardiovascular disease risk subjects with atrial fibrillation remain inconclusive...
June 2016: Medicine (Baltimore)
Eugenia Quiros-Roldan, Elena Raffetti, Emanuele Focà, Nigritella Brianese, Alice Ferraresi, Giuseppe Paraninfo, Maria Chiara Pezzoli, Andrea Bonito, Michele Magoni, Carmelo Scarcella, Francesco Castelli
Cardiovascular diseases are currently a main cause of death among people living with HIV. This population-based study aimed to investigate the incidence of cardiovascular events (CVEs) in HIV-positive people and factors associated with CVEs. We performed a retrospective cohort study of the HIV-infected patients residing in the Local Health Authority of Brescia, northern Italy, from 2000 to 2012. Incidence of CVEs events in HIV-positive patients was compared with that expected in general population living in the same area, computing standardized incidence ratios (SIRs)...
June 20, 2016: AIDS Care
Zheng-Sheng Yang, Ning-Ning Lin, Li Li, Yang Li
TNF inhibitors have been used in psoriasis (Pso) and psoriatic arthritis (PsA), which were associated with increased risk of cardiac and cerebrovascular events. However, whether TNF inhibitors reduce cardiovascular event is still unclear. Therefore, we aimed to evaluate the effect of TNF inhibitors on adverse cardiovascular events (CVEs) in Pso with or without PsA. We undertook a meta-analysis of clinical trials identified in systematic searches of MEDLINE, EMBASE, Wanfang database, Cochrane Database, and Google scholar through December 31, 2015...
October 2016: Clinical Reviews in Allergy & Immunology
Crina Rusu, Simona Racasan, Diana Moldovan, Ina Maria Kacso, Alina Potra, Cosmina Bondor, Ioan Mihai Patiu, Dan Vladutiu, Mirela Gherman Caprioara
CONTEXT: Soluble CD40 ligand (sCD40l) can predict cardiovascular events (CVE) and mortality in hemodialysis (HD) patients (short, medium term follow-up studies). OBJECTIVE: To evaluate the relationship between sCD40l and survival, CVE and mortality in HD patients on long-term follow-up. METHODS: We registered in 46 HD patients baseline characteristics, mortality and CVE for 108 months. RESULTS: SCD40l correlated positively with C-reactive protein, was higher in survivors, but had no impact on survival and was not predictive for CVE or mortality...
June 13, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
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