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https://www.readbyqxmd.com/read/29276900/-heart-failure-with-preserved-and-slightly-impaired-ejection-fraction-and-cardiovascular-events-pathogenetic-interrelations-as-a-part-of-the-cardiovascular-continuum
#1
A A Nekrasov, E S Timoshchenko, E V Karpukhina, O V Melnichenko
AIM: To evaluate the effect of decompensated HF with preserved or slightly impaired EF on the risk of cardiovascular complications during a 5‑year follow-up. MATERIALS AND METHODS: 33 patients with arterial hypertension and HF with preserved or slightly impaired EF (NT-proBNP ≥125 pg/ml, mean, 500.1±590.32 pg/ml and EF ≥40 %, mean, 57.0±10.29 %) were observed for 5 years. EchoCG, markers of immune inflammation and hormonal changes (endothelin, tumor necrosis factor (TNF), interleukin-6 (IL-6), aldosterone, renin) were evaluated at baseline...
2017: Kardiologiia
https://www.readbyqxmd.com/read/29276211/treatment-patterns-statin-intolerance-and-subsequent-cardiovascular-events-among-japanese-patients-with-high-cardiovascular-risk-initiating-statin-therapy
#2
Saurabh P Nagar, Pratik P Rane, Kathleen M Fox, Juliana Meyers, Keith Davis, Anne Beaubrun, Hyoe Inomata, Yi Qian, Kouji Kajinami
BACKGROUND: This study examined treatment patterns, possible statin intolerance, and incidence of cardiovascular events (CVEs) in 2 cohorts of patients with high cardiovascular risk (i.e., patients with atherosclerotic cardiovascular disease [ASCVD] and patients with diabetes mellitus).Methods and Results:A retrospective cohort study examined adults initiating either a statin or ezetimibe from 1 January 2006 to 31 May 2014 in the Japan Medical Data Center database. The first observed statin or ezetimibe prescription defined the index date...
December 23, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29246718/lower-extremity-arterial-calcification-on-preoperative-knee-radiographs-as-a-predictor-of-postoperative-cardiovascular-events-after-primary-total-knee-arthroplasty
#3
David Cantu Morales, Justin de Beer, Danielle Petruccelli, Conrad Kabali, Mitch Winemaker
BACKGROUND: A cross-sectional study of total knee arthroplasty (TKA) patients was conducted to determine the association of lower-extremity arterial calcification (LEAC) with acute perioperative cardiovascular events (CVEs). METHODS: Regression modeling was used to examine the association of radiographic presence of LEAC and acute myocardial infarction (MI), perioperative CVE, 30-day CVE readmit, and 30-day and 1-year mortality. RESULTS: Of 900 TKA patients, LEAC was identified in 21...
November 29, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29229303/pretransplant-coronary-artery-disease-is-a-predictor-for-myocardial-infarction-and-cardiac-death-after-liver-transplantation
#4
F Darstein, M Hoppe-Lotichius, J Vollmar, V Weyer-Elberich, A Zimmermann, J Mittler, G Otto, H Lang, P R Galle, T Zimmermann
BACKGROUND: Cardiovascular disease is a serious problem of liver transplant (LT) recipients because of increased cardiovascular risk due to immunosuppressive therapy, higher age, intraoperative risk and comorbidities (such as diabetes and nicotine abuse). Reported frequency of cardiovascular events after LT shows a high variability between different LT cohorts. Our aim was to analyze a cohort of LT recipients from a single center in Germany to evaluate frequency of the cardiovascular endpoints (CVE) myocardial infarction and/or cardiac death after LT and to investigate correlations of CVE post LT with pretransplant patient characteristics...
December 8, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29219795/-platelet-function-tests-tailored-antiplatelet-therapy-for-vascular-patients
#5
A R T Brand, S J A Korporaal, R T Urbanus, G Pasterkamp, G J de Borst
- Platelet aggregation inhibitors, also known as antiplatelet therapy (APT), are prescribed for the prevention of secondary cardiovascular events (CVE) after endovascular revascularization procedures.- Platelet aggregation inhibitors are not equally effective in all patients. The phenomenon of high residual platelet reactivity despite APT is called 'high on-treatment platelet reactivity' (HTPR); it bears an increased risk of secondary CVE.- Platelet function tests (PFT) can be used to diagnose HTPR. There are various tests available; of those, light transmission aggregometry (LTA) is considered the gold standard...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29216215/accelerating-cross-validation-with-total-variation-and-its-application-to-super-resolution-imaging
#6
Tomoyuki Obuchi, Shiro Ikeda, Kazunori Akiyama, Yoshiyuki Kabashima
We develop an approximation formula for the cross-validation error (CVE) of a sparse linear regression penalized by ℓ1-norm and total variation terms, which is based on a perturbative expansion utilizing the largeness of both the data dimensionality and the model. The developed formula allows us to reduce the necessary computational cost of the CVE evaluation significantly. The practicality of the formula is tested through application to simulated black-hole image reconstruction on the event-horizon scale with super resolution...
2017: PloS One
https://www.readbyqxmd.com/read/29195855/modeling-of-the-effects-of-il-17-and-tnf-%C3%AE-on-endothelial-cells-and-thrombus-growth
#7
Anass Bouchnita, Pierre Miossec, Alen Tosenberger, Vitaly Volpert
Rheumatoid and psoriatic arthritis are chronic inflammatory diseases, with massive increase of cardiovascular events (CVE), and contribution of the cytokines TNF-α and IL-17. Chronic inflammation inside the joint membrane or synovium results from the activation of fibroblasts/synoviocytes, and leads to the release of cytokines from monocytes (Tumor Necrosis Factor or TNF) and from T lymphocytes (Interleukin-17 or IL-17). At the systemic level, the very same cytokines affect endothelial cells and vessel wall...
November 28, 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/29163090/community-violence-exposure-and-conduct-problems-in-children-and-adolescents-with-conduct-disorder-and-healthy-controls
#8
Linda Kersten, Noortje Vriends, Martin Steppan, Nora M Raschle, Martin Praetzlich, Helena Oldenhof, Robert Vermeiren, Lucres Jansen, Katharina Ackermann, Anka Bernhard, Anne Martinelli, Karen Gonzalez-Madruga, Ignazio Puzzo, Amy Wells, Jack C Rogers, Roberta Clanton, Rosalind H Baker, Liam Grisley, Sarah Baumann, Malou Gundlach, Gregor Kohls, Miguel A Gonzalez-Torres, Eva Sesma-Pardo, Roberta Dochnal, Helen Lazaratou, Zacharias Kalogerakis, Aitana Bigorra Gualba, Areti Smaragdi, Réka Siklósi, Dimitris Dikeos, Amaia Hervás, Aranzazu Fernández-Rivas, Stephane A De Brito, Kerstin Konrad, Beate Herpertz-Dahlmann, Graeme Fairchild, Christine M Freitag, Arne Popma, Meinhard Kieser, Christina Stadler
Exposure to community violence through witnessing or being directly victimized has been associated with conduct problems in a range of studies. However, the relationship between community violence exposure (CVE) and conduct problems has never been studied separately in healthy individuals and individuals with conduct disorder (CD). Therefore, it is not clear whether the association between CVE and conduct problems is due to confounding factors, because those with high conduct problems also tend to live in more violent neighborhoods, i...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29126655/incidence-of-infective-endocarditis-and-its-thromboembolic-complications-in-a-pediatric-population-over-30years
#9
K Thom, A Hanslik, J L Russell, S Williams, P Sivaprakasam, U Allen, C Male, L R Brandão
BACKGROUND: Pediatric infective endocarditis (IE) has been associated with high morbidity and mortality, mostly related to thromboembolic complications (TEC). The objective of our study was to describe the experience in children with IE and to review the changes over a thirty-year period, regarding origin of IE, incidence of vegetations, TEC and their respective morbidity and mortality rates. METHODS: A retrospective chart review of children aged 0-18years with IE defined by the Duke Criteria and admitted to The Hospital for Sick Children, was conducted...
November 7, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29121742/retinopathy-and-left-ventricular-hypertrophy-in-patients-with-chronic-kidney-disease-interrelationship-and-impact-on-clinical-outcomes
#10
Yaeni Kim, Jung Sun Cho, Won-Kyung Cho, Hye Eun Yoon, Yu Ah Hong, Yoon Kyung Chang, Chul Woo Yang, Suk Young Kim, Hyeon Seok Hwang
BACKGROUND: Retinopathy and left ventricular hypertrophy (LVH) are representative markers of microvascular and cardiac dysfunction in patients with chronic kidney disease (CKD). However, their relationship and their combined effects on clinical outcomes are unknown. METHODS: We included 401 patients with nondialysis-dependent CKD stage 3-5 who had been examined with fundus photography for diabetic or hypertensive retinopathy. The presence of LVH was identified by echocardiography...
December 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29111335/estimated-glomerular-filtration-rate-cardiovascular-events-and-mortality-across-age-groups-among-individuals-older-than-60-years-in-southern-europe
#11
Betlem Salvador-González, Neus Gil-Terrón, M Jesús Cerain-Herrero, Isaac Subirana, Roser Güell-Miró, Luisa M Rodríguez-Latre, Oriol Cunillera-Puértolas, Roberto Elosua, Maria Grau, Joan Vila, Luisa Pascual-Benito, Jordi Mestre-Ferrer, Rafel Ramos, José Miguel Baena-Díez, Maria Soler-Vila, Eva Alonso-Bes, Laura Ruipérez-Guijarro, Virtudes Álvarez-Funes, Esther Freixes-Villaró, Mercedes Rodríguez-Pascual, Alberto Martínez-Castelao
INTRODUCTION AND OBJECTIVES: Individuals with a decreased estimated glomerular filtration rate (eGFR) are at increased risk of all-cause (ACM) and cardiovascular mortality; there is ongoing debate about whether older individuals with eGFR 45 to 59mL/min/1.73 m(2) are also at increased risk. We evaluated the association between eGFR and ACM and cardiovascular events (CVE) in people aged 60 to 74 and ≥ 75 years in a population with a low coronary disease incidence. METHODS: We conducted a retrospective cohort study by using primary care and hospital electronic records...
October 27, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29093154/evolution-of-risk-factors-for-atherosclerotic-cardiovascular-events-in-systemic-lupus-erythematosus-a-longterm-prospective-study
#12
Konstantinos Tselios, Dafna D Gladman, Jiandong Su, Olga Ace, Murray B Urowitz
OBJECTIVE: We previously reported the effect of certain factors on cardiovascular disease (CVD) in 250 women with systemic lupus erythematosus (SLE) followed for 8 years. The aim of this study was to delineate their evolution after 15 years of followup. METHODS: There were 210 women with SLE and 138 age-matched healthy women available for analysis after 15 years. Cardiovascular events (CVE) included angina pectoris, myocardial infarction (fatal and nonfatal), transient ischemic attack, and stroke (fatal and nonfatal)...
December 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29070878/the-j-curve-association-between-systolic-blood-pressure-and-clinical-outcomes-in-ischemic-stroke-or-tia-the-boss-study
#13
Xuewei Xie, Jie Xu, Hongqiu Gu, Yongli Tao, Pan Chen, Yilong Wang, Yongjun Wang
We aimed to assess the association between systolic blood pressure (SBP) and clinical outcome in 2,397 ischemic stroke (IS) or transient ischemic attack (TIA) patients from the Blood Pressure and Clinical Outcome in TIA or Ischemic Stroke (BOSS) study. BOSS study was a hospital-based, prospective cohort study. The SBP was defined as mean value of 90 days self-measured SBP after onset. Cox proportional hazards models were conducted to test the risk of combined vascular events (CVE) and stroke recurrence among different SBP categories...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29067083/the-long-term-prognosis-of-epilepsy-patients-with-medically-treated-over-a-period-of-eight-years-in-turkey
#14
Pelin Duman, Asuman Orhan Varoglu, Esra Kurum
OBJECTIVE: The aim of this study was to investigate the effect of demographic and clinical characteristics on temporal changes in seizure control and frequency in medically treated epilepsy patients to guide treatment modalities. METHODS: We retrospectively analyzed the association between clinical and demographic characteristics and seizure frequency in 1329 epilepsy patients who were followed up at an outpatient clinic for one to eight years, 2008-2015.. RESULTS: Younger age at first seizure (p = 0...
July 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29049308/the-relationship-between-intradialytic-hypotension-and-vascular-calcification-in-hemodialysis-patients
#15
AJin Cho, Young-Ki Lee, Jieun Oh, Jong-Woo Yoon, Dong Ho Shin, Hee Jung Jeon, Myung-Jin Choi, Jung-Woo Noh
BACKGROUND: Vascular calcification is associated with structural and functional abnormality of the heart and blood vessels. We investigated the relationship between intradialytic hypotension (IDH) and vascular calcification in hemodialysis (HD) patients, and their impacts on cardiovascular events (CVEs). METHOD: We enrolled 191 maintenance HD patients who underwent plain abdomen radiography for abdominal aortic calcification score (AACS). A nadir systolic blood pressure (BP) < 90 mm Hg or the requirement of bolus fluid administration was required to quantify the hypotension diagnosis...
2017: PloS One
https://www.readbyqxmd.com/read/29046320/mortality-and-cerebrovascular-events-following-heart-rhythm-disorder-management-procedures
#16
Justin Z Lee, Jayna Ling, Nancy N Diehl, David O Hodge, Deepak Padmanabhan, Ammar M Killu, Malini Madhavan, Peter A Noseworthy, Suraj Kapa, Christopher J McLeod, Yong-Mei Cha, Abhishek J Deshmukh, Komandoor Srivathsan, Fred M Kusumoto, Win-Kuang Shen, Paul A Friedman, Thomas M Munger, Samuel J Asirvatham, Douglas L Packer, Siva K Mulpuru
Background -Recognition of rates and causes of hard, patient-centered outcomes of death and cerebrovascular event (CVE) after heart rhythm disorder management (HRDM) procedures is an essential step for development of quality improvement programs in electrophysiology laboratories. Our primary aim was to assess and characterize death and CVE (stroke or transient ischemic attack) after HRDM procedures over a 17-year period. Methods -We performed a retrospective cohort study of all patients undergoing HRDM procedures between January 2000 and November 2016 at the Mayo Clinic...
October 18, 2017: Circulation
https://www.readbyqxmd.com/read/29045466/factors-predicting-cardiovascular-events-in-chronic-kidney-disease-patients-role-of-subclinical-atheromatosis-extent-assessed-by-vascular-ultrasound
#17
José M Valdivielso, Angels Betriu, Montserrat Martinez-Alonso, David Arroyo, Marcelino Bermudez-Lopez, Elvira Fernandez
Patients with chronic kidney disease (CKD) have an increased incidence of cardiovascular events (CVE). The contribution of subclinical atheromatosis extent, including femoral arteries, to CVE in CKD patients has not been investigated. In this paper, we examine the prognostic value of subclinical atheromatosis extent, assessed as the number of arterial territories with plaque, in predicting the incidence of major and minor CVE. The NEFRONA is a multicenter, prospective cohorts study that recruited 2445 CKD subjects and 559 controls, free from previous cardiovascular disease, in 81 medical centers across Spain...
2017: PloS One
https://www.readbyqxmd.com/read/29038665/c-reactive-protein-as-an-independent-cardiovascular-risk-predictor-in-hiv-patients-a-focused-review-of-published-studies
#18
REVIEW
Tarvinder S Gilotra, Stephen A Geraci
Patients infected with the human immunodeficiency virus (HIV+) are living longer and at heightened risk for developing cardiovascular events (CVEs). Commonly used prediction tools appear to misrepresent their CVE risk to varying degrees and in varying directions. Inclusion of markers of cellular infection, chronic immune activation and/or systemic inflammation into risk models might provide better predictive accuracy. Observational studies assessing the relationship of high-sensitivity C-reactive protein (hs-CRP) to CVE in HIV+ patients have reported inconsistent findings...
November 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29019809/atrial-fibrillation-and-central-nervous-complications-in-liver-transplanted-hereditary-transthyretin-amyloidosis-patients
#19
Niklas Wange, Intissar Anan, Bo-Göran Ericzon, Johanna Pennlert, Björn Pilebro, Ole B Suhr, Jonas Wixner
BACKGROUND: Central nervous system (CNS) complications are increasingly noted in liver transplanted (LTx) hereditary transthyretin amyloid (ATTRm) amyloidosis patients; this suggests that the increased survival allows for intracranial ATTRm formation from brain synthesised mutant TTR. However, atrial fibrillation (AF), a recognised risk factor for ischemic CNS complications, is also observed after LTx. The aim of the study was to investigate the occurrence of CNS complications and AF in LTx ATTRm amyloidosis patients...
October 11, 2017: Transplantation
https://www.readbyqxmd.com/read/29019632/racial-and-ethnic-health-disparities-and-trauma-informed-care-for-children-exposed-to-community-violence
#20
Bradley C Stolbach, Seeba Anam
Racial and ethnic disparities in health outcomes and access have been consistently documented for a wide variety of physical and behavioral health conditions. Health inequities are most pronounced in areas with high levels of racial and ethnic segregation, where children and adolescents are also more likely to face economic inequality, which places them at high risk for exposure to neighborhood violence and traumatic loss. Community violence exposure (CVE) has been increasingly recognized as a prominent contributor to negative physical and mental health outcomes...
October 1, 2017: Pediatric Annals
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