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https://www.readbyqxmd.com/read/29768322/lung-cancer-screening-ct-based-coronary-artery-calcification-in-predicting-cardiovascular-events-a-systematic-review-and-meta-analysis
#1
Lili Fan, Kaikai Fan
BACKGROUND: Coronary artery calcificition (CAC) is a well-established predictor of cardiovascular events (CVEs). We aimed to evaluate whether lung cancer screening computed tomography (CT)-based CAC score has a good cost-effectiveness for predicting CVEs in heavy smokers. METHODS: A literature search was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Pubmed, EMBASE, and Cochrane library databases were systematically searched for relevant studies that investigated the association between lung cancer screening CT-based CAC and CVEs up to December 31, 2017...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29748857/dynamic-of-changes-in-coronary-artery-calcification-in-early-rheumatoid-arthritis-patients-over-18-months
#2
Helen V Udachkina, Diana S Novikova, Tatiana V Popkova, Irina G Kirillova, Evgenia I Markelova
The coronary artery calcification (CAC) progression may be useful noninvasive predictor of future cardiovascular events (CVE). The progression rate of CAC in patients with early rheumatoid arthritis (RA) is poorly understood. To assess the dynamic of CAC scores in early RA patients for 18 months, 74 RA adult patients (ACR/EULAR criteria, 2010, duration ≤ 12 months, with moderate/high RA activity, without prior administration of disease-modifying anti-rheumatic drugs or glucocorticoids) were enrolled within the framework of the observational study: women 73%, median age 56 years, median RA duration 6 months, median DAS28[ESR] 5...
May 11, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29747629/in-vitro-evaluation-of-the-synergistic-antioxidant-and-anti-inflammatory-activities-of-the-combined-extracts-from-malaysian-ganoderma-lucidum-and-egyptian-chlorella-vulgaris
#3
Marwa M Abu-Serie, Noha H Habashy, Wafaa E Attia
BACKGROUND: Since oxidative stress and inflammation are two linked factors in the pathogenesis of several human diseases. Thus identification of effective treatment is of great importance. Edible mushroom and microalgae are rich in the effective antioxidant phytochemicals. Hence, their beneficial effects on oxidative stress-associated inflammation are extremely required to be investigated. METHODS: This study evaluated the functional constituents, antioxidant and anti-inflammatory activities of Malaysian Ganoderma lucidum aqueous extract (GLE) and Egyptian Chlorella vulgaris ethanolic extract (CVE)...
May 10, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29747383/current-role-of-lipoprotein-apheresis-in-the-treatment-of-high-risk-patients
#4
REVIEW
Ulrich Julius
Lipoprotein apheresis (LA) is a therapeutic approach to save the lives of patients who are at an extremely high risk of developing cardiovascular events (CVE), especially after all other therapeutic options were not tolerated, or appeared not to be effective enough. Homozygous familial hypercholesterolemia represents a clear indication to start LA therapy. Another recognized indication is a severe hypercholesterolemia, which induced CVE, often in association with other risk factors. In the last years, an expressive elevation of lipoprotein(a) (Lp(a)) emerged as an indication for LA...
May 9, 2018: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/29744914/association-of-alendronate-and-risk-of-cardiovascular-events-in-patients-with-hip-fracture
#5
Chor-Wing Sing, Angel Ys Wong, Douglas P Kiel, Elaine Yn Cheung, Joanne Ky Lam, Tommy T Cheung, Esther W Chan, Annie Wc Kung, Ian Ck Wong, Ching-Lung Cheung
The risk of cardiovascular events (CVEs) with alendronate use in real-world hip fracture patients is unknown. This study aimed to investigate the risk of CVE with and without use of alendronate in patients with hip fracture. We conducted a retrospective cohort study using a population-wide database managed by the Hong Kong Hospital Authority. Patients newly diagnosed with hip fracture from 2005 through 2013 were followed until November 6, 2016. Alendronate and other antiosteoporosis medications use during the study period were examined...
May 9, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29731018/can-we-eliminate-low-density-lipoprotein-cholesterol-related-cardiovascular-events-through-more-aggressive-primary-prevention-therapy
#6
G B John Mancini, Robert A Hegele
Intravascular levels of low-density lipoprotein cholesterol (LDL-C) at approximately ≤ 0.6 mmol/L are likely to minimize, and perhaps eliminate, LDL-C-related vascular toxicity while having no effect on essential, intracellular cholesterol homeostatic pathways, according to accumulated knowledge from basic science. Randomized clinical trials, observational reports, and Mendelian randomization trials are also forcing a reconsideration of what "normal" LDL-C means. Recent trials of secondary prevention have substantiated that such levels are safe and associated with a decreased risk of cardiovascular events (CVEs) compared with patients with higher levels of LDL-C...
May 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29725245/vascular-calcification-and-left-ventricular-hypertrophy-in-hemodialysis-patients-interrelationship-and-clinical-impacts
#7
Hyeon Seok Hwang, Jung Sun Cho, Yu Ah Hong, Yoon Kyung Chang, Suk Young Kim, Seok Joon Shin, Hye Eun Yoon
Background: We examined the relationship and combined effect of vascular calcification (VC) and left ventricular hypertrophy (LVH) on deaths and cardiovascular events (CVEs) in hemodialysis (HD) patients. Methods: Maintenance HD patients (n=341) were included. Echocardiography data and plain chest radiographs were used to assess LVH and aortic arch VC. Results: VC was found in 100 patients (29.3%). LVH was more prevalent in patients with VC compared with those without VC (70% vs. 50.2%, P =0.001). VC was independently associated with a 2...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29708911/closure-of-patent-foramen-ovale-or-medical-therapy-alone-for-secondary-prevention-of-cryptogenic-cerebrovascular-events
#8
Federico Fortuni, Gabriele Crimi, Sergio Leonardi, Filippo Angelini, Arturo Raisaro, Luca Franco Lanzarini, Luigi Oltrona Visconti, Maurizio Ferrario, Gaetano Maria De Ferrari
AIMS: About one-third of ischemic stroke are cryptogenic. Paradoxical embolism through patent foramen ovale (PFO) has been identified as a possible cause of cryptogenic stroke. Therefore, PFO closure has been considered for secondary prevention of cryptogenic stroke. However, randomized clinical trials (RCTs) comparing PFO closure versus medical therapy led to conflicting results. Our objectives were to examine if PFO closure is superior to medical therapy alone for secondary prevention of cryptogenic stroke and to investigate whether PFO closure is associated with an increased incidence of atrial fibrillation/atrial flutter (AFL)...
April 27, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29694950/is-sclerostin-level-associated-with-cardiovascular-diseases-in-hemodialysis-patients
#9
Gokce Kundakci Gelir, Sule Sengul, Gokhan Nergizoglu, Sehsuvar Ertürk, Neval Duman, Sim Kutlay
BACKGROUND/AIMS: The objective of this study is to evaluate the relation between sclerostin, arterial stiffness, and cardiovascular events (CVE) in hemodialysis patients (HD). METHODS: Sclerostin level and carotid-femoral pulse wave velocity (PWV) in 97 HD patients and sclerostin level in 40 controls were measured. RESULTS: Sclerostin level was significantly higher in patients than in controls. Sclerostin associated positively with age, male gender, cardiovascular disease, statin use, BMI, and PWV while negatively with alkaline phosphatase, parathormone (PTH), Kt/V, cinacalcet and vitamin D use in univariable correlation analyses...
April 25, 2018: Blood Purification
https://www.readbyqxmd.com/read/29659657/prognostic-value-of-electrocardiographic-left-ventricular-hypertrophy-on-cardiovascular-risk-in-a-non-hypertensive-community-based-population
#10
Kentaro Tanaka, Fumitaka Tanaka, Toshiyuki Onoda, Kozo Tanno, Masaki Ohsawa, Kiyomi Sakata, Shinichi Omama, Kuniaki Ogasawara, Yasuhiro Ishibashi, Kazuyoshi Itai, Toru Kuribayashi, Akira Okayama, Motoyuki Nakamura
BACKGROUND: The appearance of left ventricular hypertrophy on 12-lead electrocardiography (ECG-LVH) has been clarified to be associated with the risk of incidence of cardiovascular events (CVEs) in hypertensive individuals and the general population, but not enough in non-hypertensive individuals. METHODS: A total of 4,927 non-hypertensive individuals ≥ 40 years of age who were free of CVE in the general population were followed for the incidence of CVE. ECG-LVH was defined according to criteria of the Sokolow-Lyon (SL) voltage, Cornell voltage (CV), or Cornell voltage product (CP)...
April 6, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29651791/a-discrete-event-simulation-model-to-assess-the-economic-value-of-a-hypothetical-pharmacogenomics-test-for-statin-induced-myopathy-in-patients-initiating-a-statin-in-secondary-cardiovascular-prevention
#11
Dominic Mitchell, Jason R Guertin, Anick Dubois, Marie-Pierre Dubé, Jean-Claude Tardif, Ange Christelle Iliza, Fiorella Fanton-Aita, Alexis Matteau, Jacques LeLorier
BACKGROUND: Statin (HMG-CoA reductase inhibitor) therapy is the mainstay dyslipidemia treatment and reduces the risk of a cardiovascular (CV) event (CVE) by up to 35%. However, adherence to statin therapy is poor. One reason patients discontinue statin therapy is musculoskeletal pain and the associated risk of rhabdomyolysis. Research is ongoing to develop a pharmacogenomics (PGx) test for statin-induced myopathy as an alternative to the current diagnosis method, which relies on creatine kinase levels...
April 12, 2018: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/29619867/usefulness-of-pretransplant-aortic-arch-calcification-evaluation-for-kidney-transplant-outcome-prediction-in-one-year-follow-up
#12
Agne Laucyte-Cibulskiene, Evelina Boreikaite, Gediminas Aucina, Migle Gudynaite, Ilona Rudminiene, Sigita Anisko, Loreta Vareikiene, Liutauras Gumbys, Dileta Valanciene, Ligita Ryliskyte, Kestutis Strupas, Laurynas Rimsevicius, Marius Miglinas
Vascular calcification (VC) is linked to post-transplant cardiovascular events and hypercalcemia which may influence kidney graft function in the long term. We aimed to evaluate whether pretransplant aortic arch calcification (AoAC) can predict post-transplant cardiovascular or cerebrovascular events (CVEs), and to assess its association with post-transplant plasma calcium levels and renal function in one-year follow-up. Our single-center observational prospective study enrolled 37 kidney transplant recipients (KTR) without previous history of vascular events...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29601845/the-evolution-distribution-and-diversity-of-endogenous-circoviral-elements-in-vertebrate-genomes
#13
Tristan P W Dennis, William Marciel de Souza, Soledad Marsile-Medun, Joshua B Singer, Sam J Wilson, Robert J Gifford
Circoviruses (family Circoviridae) are small, non-enveloped viruses that have short, single-stranded DNA genomes. Circovirus sequences are frequently recovered in metagenomic investigations, indicating that these viruses are widespread, yet they remain relatively poorly understood. Endogenous circoviral elements (CVe) are DNA sequences derived from circoviruses that occur in vertebrate genomes. CVe are a useful source of information about the biology and evolution of circoviruses. In this study, we screened 362 vertebrate genome assemblies in silico to generate a catalog of CVe loci...
March 27, 2018: Virus Research
https://www.readbyqxmd.com/read/29560561/understanding-performance-and-verbal-communication-of-children-with-asd-in-a-collaborative-virtual-environment
#14
Lian Zhang, Zachary Warren, Amy Swanson, Amy Weitlauf, Nilanjan Sarkar
Collaborative virtual environments (CVEs), which allow naturalistic communication between two or more individuals in a shared virtual environment, hold promise as a tool for measuring and promoting social communication between peers. In this work, a CVE platform and a set of CVE-based collaborative games are designed for children with autism spectrum disorder (ASD). Two groups (7 ASD/TD pairs; 7 TD/TD pairs) participated in a pilot study to establish system feasibility and tolerability. We also designed a methodology for capturing meaningful metrics of social communication...
March 20, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29554376/high-sensitivity-cardiac-troponin-i-is-a-biomarker-for-occult-coronary-plaque-burden-and-cardiovascular-events-in-patients-with-rheumatoid-arthritis
#15
George A Karpouzas, Joel Estis, Panteha Rezaeian, John Todd, Matthew J Budoff
Objectives: Patients with RA display greater occult coronary atherosclerosis burden and experience higher cardiovascular morbidity and mortality compared with controls. We here explored whether pro-inflammatory cytokines and high-sensitivity cardiac troponin I (hs-cTnI), a biomarker of myocardial injury, correlated with plaque burden and cardiovascular events (CVEs) in RA. Methods: We evaluated 150 patients with 64-slice coronary CT angiography. Coronary artery calcium, number of segments with plaque (segment involvement score), stenotic severity and plaque burden were assessed...
June 1, 2018: Rheumatology
https://www.readbyqxmd.com/read/29534683/challenges-of-interpreting-epidemiologic-surveillance-pertussis-data-with-changing-diagnostic-and-immunization-practices-the-case-of-the-state-of-s%C3%A3-o-paulo-brazil
#16
Eder Gatti Fernandes, Ana Marli Christovam Sartori, Patrícia Coelho de Soárez, Telma Regina M P Carvalhanas, Marcela Rodrigues, Hillegonda Maria Dutilh Novaes
BACKGROUND: A significant increase in pertussis incidence occurred in Brazil, from 2011 to 2014, despite high coverage of childhood immunization with whole-cell-pertussis (wP) containing vaccines. This study presents pertussis surveillance data from São Paulo state and discusses the challenges to interpret them considering pertussis cyclic epidemic behavior, the introduction of new diagnostic techniques and new vaccination strategies, and enhanced disease awareness during epidemics. METHODS: Observational study including pertussis cases reported to the Surveillance System in São Paulo state, from January 2001 to December 2015...
March 13, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29527462/vascular-robustness-the-missing-parameter-in-cardiovascular-risk-prediction
#17
Lutz E Kraushaar, Alexander Dressel, Alexander Maßmann
Undetected high risk for premature death of cardiovascular disease (CVD) among individuals with low-to-moderate risk factor scores is an acknowledged obstacle to CVD prevention. The vasculature's functional robustness against risk factor derailment may serve as a novel discriminator of mortality risk under similar risk factor loads. To test this assumption, we hypothesized that the expected inverse robustness-mortality association is verifiable as a significant trend along the age spectrum of risk factor-challenged cohorts...
March 2018: Preventive Medicine Reports
https://www.readbyqxmd.com/read/29513397/anticoagulation-use-and-clinical-outcomes-after-catheter-ablation-in-patients-with-persistent-and-longstanding-persistent-atrial-fibrillation
#18
Jackson J Liang, Melissa A Elafros, Michael T Mullen, Daniele Muser, Tatsuya Hayashi, Andres Enriquez, Rajeev K Pathak, Erica S Zado, Pasquale Santangeli, Jeffrey S Arkles, Robert D Schaller, Gregory E Supple, David S Frankel, Fermin C Garcia, Rajat Deo, David Lin, Michael P Riley, Saman Nazarian, Sanjay Dixit, Francis E Marchlinski, David J Callans
INTRODUCTION: Whether successful catheter ablation for atrial fibrillation (AF) reduces risk of cerebrovascular events (CVEs) remains controversial and whether oral anticoagulation therapy (OAT) can be safely discontinued in patients rendered free of AF recurrences remains unknown. We evaluated OAT use patterns and examined long-term rates of CVEs (stroke/TIA) and major bleeding episodes (MBEs) in patients with nonparoxysmal AF treated with catheter ablation. METHODS AND RESULTS: Four hundred patients with nonparoxysmal AF (200 persistent, 200 longstanding persistent; mean age 60...
March 7, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29493818/cytomegalovirus-reactivation-in-liver-transplant-recipients-due-to-hepatitis-c-cirrhosis-is-associated-with-higher-cardiovascular-risk-an-observational-retrospective-study
#19
Victoria Aguilera, Tommaso Di Maira, Isabel Conde, Victoria Fornés-Ferrer, Carmen Vinaixa, Carmen Pallarés, Angela Carvalho-Gomes, Almudena Cubells, María García, Ángel Rubín, Salvador Benlloch, Luisa Gonzalez-Dieguez, Jose Miguel Molina, Lorena Puchades, F Xavier López-Labrador, Martin Prieto, Marina Berenguer
The association between cytomegalovirus (CMV) reactivation and cardiovascular risk has been reported in solid organ transplant populations; however, it has yet to be assessed in liver transplantation (LT). We aim to evaluate whether CMV reactivation is associated with cardiovascular events (CVE) in HCV-LT patients. LT patients (2010 and 2014) due to HCV cirrhosis were included. Clinically significant CMV (CS-CMV) was defined as viral load (VL) >5000 copies/ml, need of therapy or CMV disease. Baseline variables and endpoint measures (CVE, survival, severe recurrent hepatitis C, de novo tumors, and diabetes) were collected...
June 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29477146/long-term-visit-to-visit-glycemic-variability-as-predictor-of-micro-and-macrovascular-complications-in-patients-with-type-2-diabetes-the-rio-de-janeiro-type-2-diabetes-cohort-study
#20
C R L Cardoso, N C Leite, C B M Moram, G F Salles
BACKGROUND: Long-term visit-to-visit glycemic variability is an additional measure of glycemic control. We aimed to evaluate the prognostic value of several measures of glycemic variability for the occurrence of micro- and macrovascular complications, and all-cause mortality in patients with type 2 diabetes. METHODS: 654 individuals were followed-up over a median of 9.3 years. Glycemic variability (SDs and coefficients of variation of HbA1c and fasting glycaemia) was measured during the first 12- and 24-months...
February 24, 2018: Cardiovascular Diabetology
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