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https://www.readbyqxmd.com/read/28654906/p53-p63-and-p73-in-the-wonderland-of-s-cerevisiae
#1
REVIEW
Olivier Billant, Marc Blondel, Cécile Voisset
Since its discovery in 1979, p53 has been on the forefront of cancer research. It is considered a master gene of cancer suppression and is found mutated in around 50% of all human tumors. In addition, the progressive identification of p53-related transcription factors p63 and p73 as well as their multiple isoforms have added further layers of complexity to an already dense network. Among the numerous models used to unravel the p53 family mysteries, S. cerevisiae has been particularly useful. This seemingly naive model allows the expression of a functional human p53 and thus the assessment of p53 intrinsic transcriptional activity...
June 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28654039/electrophysiological-method-for-whole-cell-voltage-clamp-recordings-from-drosophila-photoreceptors
#2
Ben Katz, Rita Gutorov, Elisheva Rhodes-Mordov, Roger C Hardie, Baruch Minke
Whole-cell voltage clamp recordings from Drosophila melanogaster photoreceptors have revolutionized the field of invertebrate visual transduction, enabling the use of D. melanogaster molecular genetics to study inositol-lipid signaling and Transient Receptor Potential (TRP) channels at the single-molecule level. A handful of labs have mastered this powerful technique, which enables the analysis of the physiological responses to light under highly controlled conditions. This technique allows control over the intracellular and extracellular media; the membrane voltage; and the fast application of pharmacological compounds, such as a variety of ionic or pH indicators, to the intra- and extracellular media...
June 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28654034/use-of-a-piglet-model-for-the-study-of-anesthetic-induced-developmental-neurotoxicity-aidn-a-translational-neuroscience-approach
#3
Emmett E Whitaker, Christopher Z Zheng, Bruno Bissonnette, Andrew D Miller, Tanner L Koppert, Joseph D Tobias, Christopher R Pierson, Fedias L Christofi
Anesthesia cannot be avoided in many cases when surgery is required, particularly in children. Recent investigations in animals have raised concerns that anesthesia exposure may lead to neuronal apoptosis, known as anesthesia-induced developmental neurotoxicity (AIDN). Furthermore, some clinical studies in children have suggested that anesthesia exposure may lead to neurodevelopmental deficits later in life. Nonetheless, an ideal animal model for preclinical study has yet to be developed. The neonatal piglet represents a valuable model for preclinical study, as they share a striking number of developmental similarities with humans...
June 11, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28653366/method-and-excel-vba-algorithm-for-modeling-master-recession-curve-using-trigonometry-approach
#4
Kristijan Posavec, Marco Giacopetti, Marco Materazzi, Steffen Birk
A new method was developed and implemented into an Excel Visual Basic for Applications (VBAs) algorithm utilizing trigonometry laws in an innovative way to overlap recession segments of time series and create master recession curves (MRCs). Based on a trigonometry approach, the algorithm horizontally translates succeeding recession segments of time series, placing their vertex, that is, the highest recorded value of each recession segment, directly onto the appropriate connection line defined by measurement points of a preceding recession segment...
June 26, 2017: Ground Water
https://www.readbyqxmd.com/read/28653054/the-tissue-master-concept-tmc-innovations-for-alveolar-ridge-preservation
#5
Stefan Neumeyer
No abstract text is available yet for this article.
2017: International Journal of Esthetic Dentistry
https://www.readbyqxmd.com/read/28653035/a-classification-algorithm-for-predicting-progression-from-normal-cognition-to-mild-cognitive-impairment-across-five-cohorts-the-preclinical-ad-consortium
#6
Alden L Gross, Jason J Hassenstab, Sterling C Johnson, Lindsay R Clark, Susan M Resnick, Melissa Kitner-Triolo, Colin L Masters, Paul Maruff, John C Morris, Anja Soldan, Corinne Pettigrew, Marilyn S Albert
INTRODUCTION: We established a method for diagnostic harmonization across multiple studies of preclinical Alzheimer's disease and validated the method by examining its relationship with clinical status and cognition. METHODS: Cognitive and clinical data were used from five studies (N = 1746). Consensus diagnoses established in each study used criteria to identify progressors from normal cognition to mild cognitive impairment. Correspondence was evaluated between these consensus diagnoses and three algorithmic classifications based on (1) objective cognitive impairment in 2+ tests only; (2) a Clinical Dementia Rating (CDR) of ≥0...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28652544/ghrelin-treatment-improves-physical-decline-in-sarcopenia-model-mice-through-muscular-enhancement-and-mitochondrial-activation
#7
Masanori Tamaki, Kazutoshi Miyashita, Aika Hagiwara, Shu Wakino, Hiroyuki Inoue, Kentaro Fujii, Chikako Fujii, Sho Endo, Asuka Uto, Masanori Mitsuishi, Masaaki Sato, Toshio Doi, Hiroshi Itoh
Chronic kidney disease (CKD) impairs physical performance in humans, which leads to a risk of all-cause mortality. In our previous study, we demonstrated that a reduction in muscle mitochondria rather than muscle mass was a major cause of physical decline in 5/6 nephrectomized CKD model mice. Because ghrelin administration has been reported to enhance oxygen utilization in skeletal muscle, we examined the usefulness of ghrelin for a recovery of physical decline in 5/6 nephrectomized C57Bl/6 mice, focusing on the epigenetic modification of peroxisome proliferator activated receptor gamma coactivator-1α (PGC-1α), a master regulator of mitochondrial biogenesis...
2017: Endocrine Journal
https://www.readbyqxmd.com/read/28652483/serving-two-masters-the-medical-and-political-careers-of-sir-charles-tupper
#8
T Jock Murray
No abstract text is available yet for this article.
June 26, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28652328/pathogen-exploitation-of-an-abscisic-acid-and-jasmonate-inducible-mapk-phosphatase-and-its-interception-by-arabidopsis-immunity
#9
Akira Mine, Matthias L Berens, Tatsuya Nobori, Shajahan Anver, Kaori Fukumoto, Thomas M Winkelmüller, Atsushi Takeda, Dieter Becker, Kenichi Tsuda
Phytopathogens promote virulence by, for example, exploiting signaling pathways mediated by phytohormones such as abscisic acid (ABA) and jasmonate (JA). Some plants can counteract pathogen virulence by invoking a potent form of immunity called effector-triggered immunity (ETI). Here, we report that ABA and JA mediate inactivation of the immune-associated MAP kinases (MAPKs), MPK3 and MPK6, in Arabidopsis thaliana ABA induced expression of genes encoding the protein phosphatases 2C (PP2Cs), HAI1, HAI2, and HAI3 through ABF/AREB transcription factors...
June 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28652301/stand-alone-eal-domain-proteins-form-a-distinct-subclass-of-eal-proteins-involved-in-regulation-of-cell-motility-and-biofilm-formation-in-enterobacteria
#10
Youssef El Mouali, Hyunhee Kim, Irfan Ahmad, Annelie Brauner, Ying Liu, Mikael Skurnik, Michael Y Galperin, Ute Römling
The second messenger cyclic di-GMP is almost ubiquitous among bacteria and so are the cyclic di-GMP turnover proteins, which mediate the transition between motility and sessility. EAL domain proteins have been characterized as cyclic di-GMP-specific phosphodiesterases. While most EAL domain proteins contain additional, usually N-terminal, domains, there is a distinct family of proteins within stand-alone EAL domains, exemplified by Salmonella enterica serovar Typhimurium proteins STM3611 (YhjH/PdeH), a c-di-GMP-specific phosphodiesterase, and the enzymatically inactive STM1344 (YdiV/CdgR) and STM1697, which regulate bacterial motility through interaction with the flagella master regulator FlhDC...
June 26, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28652179/non-coding-rna-regulation-of-t-cell-biology-implications-for-age-associated-cardiovascular-diseases
#11
REVIEW
Jose Coelho-Lima, Ioakim Spyridopoulos
Prevalence of age-associated cardiovascular diseases (CVD) has dramatically increased as a result of improvements in life expectancy. Chronic inflammation is a shared pathophysiological feature of age-associated CVDs, indicating a role for the immune system in the onset and development of CVDs. Indeed, ageing elicits profound changes in both the cardiovascular and immune system, especially in the T cell compartment. Although such changes have been well described at the cellular level, the molecular mechanisms underlying immune-mediated cardiovascular ageing remain largely unexplored...
June 23, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28652130/tal1-as-a-master-oncogenic-transcription-factor-in-t-cell-acute-lymphoblastic-leukemia
#12
REVIEW
Takaomi Sanda, Wei Zhong Leong
In hematopoietic cell development, the transcriptional program is strictly regulated in a lineage- and stage-specific manner that requires a number of transcription factors to work in a cascade or in a loop, in addition to interactions with non-hematopoietic cells in the microenvironment. Disruption of the transcriptional program alters the cellular state and may predispose cells to the acquisition of genetic abnormalities. Early studies have shown that proteins that promote cell differentiation often serve as tumor suppressors, whereas inhibitors of those proteins act as oncogenes in the context of acute leukemia...
June 23, 2017: Experimental Hematology
https://www.readbyqxmd.com/read/28651140/comparison-of-kinetic-analysis-methods-in-thermal-decomposition-of-cattle-manure-by-themogravimetric-analysis
#13
Guanyi Chen, Sirong He, Zhanjun Cheng, Yanan Guan, Beibei Yan, Wenchao Ma, Dennis Y C Leung
The thermogravimetric (TG) experiments of cattle manure were carried out from room temperature to 900°C at five different heating rates (10, 20, 30, 40 and 50°C/min) and the kinetics of the main decomposition process were analyzed with different methods. TG curves indicate that the major decomposition process of cattle manure could be roughly divided into three stages. The average activation energy of each stage calculated by Coats-Redfern method are 68.95, 2.63 and 55.32kJ/mol respectively. The kinetic parameters given by Distributed Activation Energy Model method, Flynn-Wall-Ozawa method and Vyazovkin method are all show that the activation energies keep stable (at around 122...
June 7, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28650804/limb-position-tolerant-pattern-recognition-for-myoelectric-prosthesis-control-with-adaptive-sparse-representations-from-extreme-learning
#14
Joseph L Betthauser, Christopher L Hunt, Luke E Osborn, Matthew R Masters, Gyorgy Levay, Rahul Reddy Kaliki, Nitish V Thakor
Myoelectric signals can be used to predict the intended movements of an amputee for prosthesis control. However, untrained effects like limb position changes influence myoelectric signal characteristics, hindering the ability of pattern recognition algorithms to discriminate among motion classes. Despite frequent and long training sessions, these deleterious conditional influences may result in poor performance and device abandonment. GOAL: We present a robust sparsity-based adaptive classification method that is significantly less sensitive to signal deviations resulting from untrained conditions...
June 23, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28650457/fibroblast-growth-factor-19-regulates-skeletal-muscle-mass-and-ameliorates-muscle-wasting-in-mice
#15
Bérengère Benoit, Emmanuelle Meugnier, Martina Castelli, Stéphanie Chanon, Aurélie Vieille-Marchiset, Christine Durand, Nadia Bendridi, Sandra Pesenti, Pierre-Axel Monternier, Anne-Cécile Durieux, Damien Freyssenet, Jennifer Rieusset, Etienne Lefai, Hubert Vidal, Jérôme Ruzzin
The endocrine-derived hormone fibroblast growth factor (FGF) 19 has recently emerged as a potential target for treating metabolic disease. Given that skeletal muscle is a key metabolic organ, we explored the role of FGF19 in that tissue. Here we report a novel function of FGF19 in regulating skeletal muscle mass through enlargement of muscle fiber size, and in protecting muscle from atrophy. Treatment with FGF19 causes skeletal muscle hypertrophy in mice, while physiological and pharmacological doses of FGF19 substantially increase the size of human myotubes in vitro...
June 26, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28650169/increasing-protein-production-rates-can-decrease-the-rate-at-which-functional-protein-is-produced-and-their-steady-state-levels
#16
Ajeet K Sharma, Edward P O'Brien
The rate at which soluble, functional protein is produced by the ribosome has recently been found to vary in complex and unexplained ways as various translation-associated rates are altered through synonymous codon substitutions. To understand this phenomenon, here, we combine a well-established ribosome-traffic model with a master-equation model of co-translational domain folding to explore the scenarios that are possible for the protein production rate, J , and the functional-nascent protein production rate, F , as the rates of various translation processes are altered for five different E...
June 26, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28650102/endocrine-influence-on-neuroinflammation-the-use-of-reporter-systems
#17
REVIEW
Nicoletta Rizzi, Alessandro Villa, Valeria Benedusi, Electra Brunialti, Nicoletta Cesari, Paolo Ciana, Adriana Maggi
Most of the ageing-associated pathologies are coupled with a strong inflammatory component that accelerates the progress of the physio-pathological functional decline related to ageing. The currently available pharmacological tools for the control of neuroinflammation present several side effects which restrict their application, particularly in chronic disorders. The discovery of the potential anti-inflammatory action exerted by endogenous estrogens and that activation of ERα results in a significant decrease of inflammation at the cellular level and in models of inflammatory diseases, prompted us to embark in a series of studies aimed at the generation of reporter systems allowing to i...
June 26, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28649736/high-aspect-ratio-sub-micrometer-channels-using-wet-etching-application-to-the-dynamics-of-red-blood-cell-transiting-through-biomimetic-splenic-slits
#18
Priya Gambhire, Scott Atwell, Cécile Iss, Frédéric Bedu, Igor Ozerov, Catherine Badens, Emmanuèle Helfer, Annie Viallat, Anne Charrier
Nanoparticles delivering drugs, disseminating cancer cells, and red blood cells (RBCs) during splenic filtration must deform and pass through the sub-micrometer and high aspect ratio interstices between the endothelial cells lining blood vessels. The dynamics of passage of particles/cells through these slit-like interstices remain poorly understood because the in vitro reproduction of slits with physiological dimensions in devices compatible with optical microscopy observations requires expensive technologies...
June 26, 2017: Small
https://www.readbyqxmd.com/read/28649719/regulation-of-growth-defense-balance-by-the-jasmonate-zim-domain-jaz-myc-transcriptional-module
#19
Ian T Major, Yuki Yoshida, Marcelo L Campos, George Kapali, Xiu-Fang Xin, Koichi Sugimoto, Dalton de Oliveira Ferreira, Sheng Yang He, Gregg A Howe
The plant hormone jasmonate (JA) promotes the degradation of JASMONATE ZIM-DOMAIN (JAZ) proteins to relieve repression on diverse transcription factors (TFs) that execute JA responses. However, little is known about how combinatorial complexity among JAZ-TF interactions maintains control over myriad aspects of growth, development, reproduction, and immunity. We used loss-of-function mutations to define epistatic interactions within the core JA signaling pathway and to investigate the contribution of MYC TFs to JA responses in Arabidopsis thaliana...
June 26, 2017: New Phytologist
https://www.readbyqxmd.com/read/28649476/a-practice-platform-for-systematic-development-of-microsurgical-instrument-technique
#20
Darius Bagli, Rakan Odeh, Frank Penna, Ethan Grober, Nicolas Fernandez, Armando Lorenzo, Lisa Satterthwaite, Adam Dubrowski
Many surgical disciplines, particularly those specializing in the pediatric age group, use microsurgical instruments with the assistance of either optical loupe or microscope magnification to perform high precision surgical procedures. We developed a course consisting of two parts: Part 1 consists of low fidelity, inanimate exercises or training and practice platform, and part 2 employed a rat model. In this report, we describe and provide templates for the first part of the course, namely the practice platform as an integral set of six low-fidelity exercises, each focusing on a specific aspect of instrument handling required to master the later use of the instruments during actual microsurgery...
May 16, 2017: Curēus
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