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https://www.readbyqxmd.com/read/28934638/a-qualitative-study-on-communication-between-nursing-students-and-the-family-members-of-patients
#1
Zenobia C Y Chan
BACKGROUND: When caring for a family as a unit, it is as crucial to communicate with the family members of a patient as it is with the patient. However, there is a lack of research on the views of nursing students on communicating with the family members of patients, and little has been mentioned in the nursing curriculum on this topic. AIM: The aim of this study was to explore nursing students' experiences of communicating with the family members of patients. DESIGN: A qualitative descriptive study...
September 12, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28934400/genomic-characterisation-of-environmental-pseudomonas-aeruginosa-isolated-from-dental-unit-waterlines-revealed-the-insertion-sequence-ispa11-as-a-chaotropic-element
#2
Antony T Vincent, Luca Freschi, Julie Jeukens, Irena Kukavica-Ibrulj, Jean-Guillaume Emond-Rheault, Annie Leduc, Brian Boyle, Fabrice Jean-Pierre, Marie-Christine Groleau, Eric Déziel, Jean Barbeau, Steve J Charette, Roger C Levesque
The bacterium Pseudomonas aeruginosa is well known to have a remarkable adaptive capacity allowing it to colonise many environments. A recent study on environmental isolates from dental unit waterlines (DUWLs) hinted at a genetic clustering into two groups. Isolates from one of these groups, named cluster III, were shown to have unusual phenotypes for environmental isolates, such as an increased biofilm production. To have a better ecological view, more specifically on isolates from cluster III, the complete genomes of 39 isolates including 16 from DUWLs were sequenced...
September 1, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28934208/ten-simple-rules-for-developing-a-mentor-mentee-expectations-document
#3
EDITORIAL
Kristyn S Masters, Pamela K Kreeger
No abstract text is available yet for this article.
September 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28933413/the-role-of-the-nrf2-are-antioxidant-system-in-preventing-cardiovascular-diseases
#4
REVIEW
Robert E Smith, Kevin Tran, Cynthia C Smith, Miranda McDonald, Pushkar Shejwalkar, Kenji Hara
It is widely believed that consuming foods and beverages that have high concentrations of antioxidants can prevent cardiovascular diseases and many types of cancer. As a result, many articles have been published that give the total antioxidant capacities of foods in vitro. However, many antioxidants behave quite differently in vivo. Some of them, such as resveratrol (in red wine) and epigallocatechin gallate or EGCG (in green tea) can activate the nuclear erythroid-2 like factor-2 (Nrf2) transcription factor...
November 11, 2016: Diseases (Basel)
https://www.readbyqxmd.com/read/28932937/foxn1-deficiency-from-the-discovery-to-novel-therapeutic-approaches
#5
REVIEW
Vera Gallo, Emilia Cirillo, Giuliana Giardino, Claudio Pignata
Since the discovery of FOXN1 deficiency, the human counterpart of the nude mouse, a growing body of evidence investigating the role of FOXN1 in thymus and skin, has been published. FOXN1 has emerged as fundamental for thymus development, function, and homeostasis, representing the master regulator of thymic epithelial and T cell development. In the skin, it also plays a pivotal role in keratinocytes and hair follicle cell differentiation, although the underlying molecular mechanisms still remain to be fully elucidated...
September 21, 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28932142/color-stability-and-marginal-integrity-of-interim-crowns-an-in-vitro-study
#6
Marwa I Elagra, Mohammad R Rayyan, Maisam M Alhomaidhi, Areej A Alanaziy, Mona O Alnefaie
OBJECTIVE: Many commercial dental materials are used to fabricate interim restorations. This study aimed to compare the color stability and the marginal integrity of four different interim crown materials. MATERIALS AND METHODS: An ivorine right maxillary central incisor was prepared for a full coverage all-ceramic restoration. A total of 36 specimens in the form of crowns were fabricated on the master die using four different materials (n = 9); Polymethyl methacrylate (PMMA) resin (TrimPLUS), PMMA computer-aided design, and computer-aided manufacturing (CAD-CAM) blocks (Ceramill TEMP), cold cure bis-acryl resin (Success CD), and bis-acryl resin dual-cure composite (TempSpan)...
July 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28931714/early-career-researchers-an-interview-with-kakani-katija
#7
(no author information available yet)
Kakani Katija is a Principal Engineer at the Monterey Bay Aquarium Research Institute, USA, where she designs and builds instrumentation to study marine invertebrate ecomechanics. She received her Bachelor's degree in Aeronautics and Astronautics from the University of Washington, USA, before moving to the California Institute of Technology, USA, for her Master's degree in Aeronautics with Morteza Gharib and PhD in Bioengineering in the laboratory of John Dabiri, completed in 2010. Katija was recognised as a National Geographic Emerging Explorer in 2011 and has given presentations at TEDYouth and TEDWomen...
September 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28931540/review-on-the-secret-life-of-ion-channels-kv1-3-potassium-channels-and-cell-proliferation
#8
M Teresa Perez Garcia, Pilar Cidad, Jose R Lopez-Lopez
Kv1.3 channels are involved in the switch to proliferation of normally quiescent cells, being implicated in the control of cell cycle in many different cell types and in many different ways. They modulate membrane potential controlling K(+) fluxes, sense changes in potential and interact with many signaling molecules through their intracellular domains. From a mechanistic point of view, we can describe the role of Kv1.3 channels in proliferation with at least three different models. In the "membrane potential model", membrane hyperpolarization resulting from Kv1...
September 20, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28931521/pgc1%C3%AE-in-the-kidney
#9
Matthew R Lynch, Mei T Tran, Samir M Parikh
Acute kidney injury (AKI) arising from diverse etiologies is characterized by mitochondrial dysfunction. The peroxisome proliferator-activated receptor γ coactivator-1alpha (PGC1α), a master regulator of mitochondrial biogenesis, has been shown to be protective in AKI. Interestingly, reduction of PGC1α has also been implicated in the development of diabetic kidney disease and renal fibrosis. The beneficial renal effects of PGC1α make it a prime target for therapeutics aimed at ameliorating AKI, forms of chronic kidney disease (CKD), and their intersection...
September 20, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28931482/policy-and-political-advocacy-comparison-study-of-nursing-faculty-to-determine-current-practices-perceptions-and-barriers-to-teaching-health-policy
#10
Suzanne Staebler, Jane Campbell, Patsy Cornelius, Amanda Fallin-Bennett, Eileen Fry-Bowers, Ying Mai Kung, David LaFevers, Janice Miller
PURPOSE: To better understand policy/advocacy concepts and methodology utilized in all levels of nursing educational programs and develop clarity concerning structure of policy content and integration across all levels of education. DESIGN AND METHODS: Cross-sectional analysis of data obtained from a survey sent to 19,043 nursing faculty in the United States; 598 total responses; 514 complete responses. Quantitative data points were analyzed using SPSS and qualitative data was grouped and analyzed by theme...
September 2017: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
https://www.readbyqxmd.com/read/28931297/-intracranial-pressure-evaluation-by-ophthalmologist
#11
J Čmelo, R Illéš, J Šteňo
The value of ICT is important in diagnosis of the diseases of the eye and orbit Methods for direct measurement of intracranial pressure (ICT) are exact, but they are invasive and there is some risk of infection and damage of the tissue. Currently there are 2 valid indirect methods of mesurement of IKT. Digital Ophthalmodynamometry (D-ODM) and Transcranial Doppler ultrasonography (TDU). D-ODM is a non-invasive method for measuring of the Pulsating Venous Pressure (VPT). We can measure VPT by the pulse phenomena...
2017: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/28931159/isolation-and-molecular-characterization-of-the-transformer-gene-from-bactrocera-cucurbitae-diptera-tephritidae
#12
Ya Luo, Santao Zhao, Jiahui Li, Peizheng Li, Rihui Yan
transformer (tra) is a switch gene of sex determination in many insects, particularly in Dipterans. However, the sex determination pathway in Bactrocera cucurbitae (Coquillett), a very destructive pest on earth, remains largely uncharacterized. In this study, we have isolated and characterized one female-specific and two male-specific transcripts of the tra gene (Bcutra) of B. cucurbitae. The genomic structure of Bcutra has been determined and the presence of multiple conserved Transformer (TRA)/TRA-2 binding sites in Bcutra has been found...
January 1, 2017: Journal of Insect Science
https://www.readbyqxmd.com/read/28930975/streamlined-single-cell-tcr-isolation-and-generation-of-retroviral-vectors-for-in-vitro-and-in-vivo-expression-of-human-tcrs
#13
Maran L Sprouse, Gabriele Blahnik, Thomas Lee, Natalie Tully, Pinaki Benarjee, Eddie A James, Maria J Redondo, Matthew L Bettini, Maria Bettini
Although, several methods for sequencing of paired T cell receptor (TCR) alpha and beta chains from single T cells have been developed, none so far have been conducive to downstream in vivo functional analysis of TCR heterodimers. We have developed an improved protocol based on a two-step multiplex-nested PCR, which results in a PCR product that spans entire variable regions of a human TCR alpha and beta chains. By identifying unique restriction sites and incorporating them into the PCR primers, we have made the PCR product compatible with direct sub-cloning into the template retroviral vector...
September 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28930640/age-related-decline-in-endurance-running-performance-an-example-of-a-multiple-world-records-holder
#14
Romuald Lepers, Thomas Cattagni
This study examined the age-related decline in endurance running performance of one of the greatest master runners ever, Ed Whitlock. His running performances from 1500 m to marathon were analyzed for five periods of 5 years from 65-69 years to 85-89 years. Despite exceptional running performances for his advanced age, the rate of decline in his performances increased after 80 years and was drastically amplified after 85 years.
September 20, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28930051/addiction-and-the-role-of-circadian-genes
#15
Laura A Forde, Gursharan Kalsi
OBJECTIVE: In mammals, intimate interactions exist between the circadian system and other molecular systems, and mounting evidence is suggesting that these relationships may affect substance use disorders. Research in preclinical models supports the role of circadian genes as risk factors for addiction. Here, we explore the evidence and review human genetic studies testing the association between specific circadian genes and substance use disorders. METHOD: A literature search was conducted in PubMed for studies testing variants in eight circadian genes known to be central to the functioning of the master clock in the brain...
September 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28929255/carbonic-anhydrase-ix-inhibition-affects-viability-of-cancer-cells-adapted-to-extracellular-acidosis
#16
Elena Andreucci, Silvia Peppicelli, Fabrizio Carta, Giulia Brisotto, Eva Biscontin, Jessica Ruzzolini, Francesca Bianchini, Alessio Biagioni, Claudiu T Supuran, Lido Calorini
Among the players of the adaptive response of cancer cells able to promote a resistant and aggressive phenotype, carbonic anhydrase IX (CAIX) recently has emerged as one of the most relevant drug targets. Indeed, CAIX targeting has received a lot of interest, and selective inhibitors are currently under clinical trials. Hypoxia has been identified as the master inductor of CAIX, but, to date, very few is known about the influence that another important characteristic of tumor microenvironment, i.e., extracellular acidosis, exerts on CAIX expression and activity...
September 19, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28928392/mucosa-associated-lymphoid-tissue-lymphoma-translocation-1-as-a-novel-therapeutic-target-for-rheumatoid-arthritis
#17
Chang Hoon Lee, Su Jeong Bae, Miok Kim
Emerging evidence suggests that mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) is a key regulator of inflammatory diseases; however, the pathological role of MALT1 in rheumatoid arthritis (RA) is not well understood. Consequently, this protein has not been therapeutically targeted for the treatment of RA. MALT1 plays a role in the paracaspase pathway, has proteolytic activity and is involved in the regulation of inflammatory responses. In this study, we found that the MALT1-targeting inhibitory small molecule, MALT1 selective inhibitor 2-chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenylacetamide (MI-2) strongly suppresses the differentiation of monocytes into osteoclasts in the absence or presence of the inflammatory cytokine tumour necrosis factor α...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28928284/functional-and-evolutionary-insights-from-the-ciona-notochord-transcriptome
#18
Wendy M Reeves, Yuye Wu, Matthew J Harder, Michael T Veeman
The notochord of the ascidian Ciona consists of only 40 cells, and is a longstanding model for studying organogenesis in a small, simple embryo. Here, we perform RNAseq on flow-sorted notochord cells from multiple stages to define a comprehensive Ciona notochord transcriptome. We identify 1364 genes with enriched expression and extensively validate the results by in situ hybridization. These genes are highly enriched for Gene Ontology terms related to the extracellular matrix, cell adhesion and cytoskeleton...
September 15, 2017: Development
https://www.readbyqxmd.com/read/28928248/carbonic-anhydrase-iii-protects-osteocytes-from-oxidative-stress
#19
Chao Shi, Yuhei Uda, Christopher Dedic, Ehab Azab, Ningyuan Sun, Amira I Hussein, Christopher A Petty, Keertik Fulzele, Maria C Mitterberger-Vogt, Werner Zwerschke, Renata Pereira, Kunzheng Wang, Paola Divieti Pajevic
Osteocytes are master orchestrators of bone remodeling; they control osteoblast and osteoclast activities both directly via cell-to-cell communication and indirectly via secreted factors, and they are the main postnatal source of sclerostin and RANKL (receptor activator of NF-kB ligand), two regulators of osteoblast and osteoclast function. Despite progress in understanding osteocyte biology and function, much remains to be elucidated. Recently developed osteocytic cell lines-together with new genome editing tools-has allowed a closer look at the biology and molecular makeup of these cells...
September 19, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28927423/primary-cilia-modulate-tlr4-mediated-inflammatory-responses-in-hippocampal-neurons
#20
Hyunjung Baek, Hyo Jung Shin, Jwa-Jin Kim, Nara Shin, Sena Kim, Min-Hee Yi, Enji Zhang, Jinpyo Hong, Joon Won Kang, Yonghyun Kim, Cuk-Seong Kim, Dong Woon Kim
BACKGROUND: The primary cilium is an organelle that can act as a master regulator of cellular signaling. Despite the presence of primary cilia in hippocampal neurons, their function is not fully understood. Recent studies have demonstrated that the primary cilium influences interleukin (IL)-1β-induced NF-κB signaling, ultimately mediating the inflammatory response. We, therefore, investigated ciliary function and NF-κB signaling in lipopolysaccharide (LPS)-induced neuroinflammation in conjunction with ciliary length analysis...
September 19, 2017: Journal of Neuroinflammation
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