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https://www.readbyqxmd.com/read/29784144/it-is-important-that-the-process-goes-quickly-isn-t-it-a-qualitative-multi-country-study-of-colorectal-or-lung-cancer-patients-narratives-of-the-timeliness-of-diagnosis-and-quality-of-care
#1
Marlene Malmström, Birgit H Rasmussen, Britt-Marie Bernhardson, Senada Hajdarevic, Lars E Eriksson, Rikke Sand Andersen, John I MacArtney
PURPOSE: The emphasis on early diagnosis to improve cancer survival has been a key factor in the development of cancer pathways across Europe. The aim of this analysis was to explore how the emphasis on early diagnosis and timely treatment is reflected in patient's accounts of care, from the first suspicion of colorectal or lung cancer to their treatment in Denmark, England and Sweden. METHOD: We recruited 155 patients in Denmark, England and Sweden who were within six months of being diagnosed with lung or colorectal cancer...
June 2018: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/29783959/soluble-urokinase-plasminogen-activator-receptor-predicts-mortality-in-exacerbated-copd
#2
Nina S Godtfredsen, Ditte V Jørgensen, Kristoffer Marsaa, Charlotte S Ulrik, Ove Andersen, Jesper Eugen-Olsen, Line J H Rasmussen
BACKGROUND: The inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) is elevated in severe acute and chronic medical conditions and has been associated with short-term mortality. The role of suPAR in predicting risk of death following an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) has never been studied. We hypothesized that increased suPAR is an independent predictor of short-term mortality in patients admitted to hospital with COPD or acute respiratory failure...
May 21, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29782391/impact-of-age-on-the-association-between-24-h-ambulatory-blood-pressure-measurements-and-target-organ-damage
#3
Thomas B Olesen, Manan Pareek, Jacob V Stidsen, Marie K Blicher, Susanne Rasmussen, Julie K K Vishram-Nielsen, Kathrine Kjaer-Hansen, Michael H Olsen
OBJECTIVE: The aim of this study was to evaluate the impact of age on the associations between hemodynamic components derived from 24-h ambulatory blood pressure (24-h ABPM) and target organ damage, in apparently healthy, nonmedicated individuals. METHODS: Twenty-four-hour ABPM and target organ damage (left ventricular mass index, pulse wave velocity, urine albumin : creatinine ratio and carotid atherosclerotic plaques) were evaluated in 1408 individuals. Associations were examined in regression models, stratified for age [middle-aged (41 or 51 years) or elderly (61 or 71 years)], and adjusted for sex, smoking status, and total-cholesterol...
May 17, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29781880/willingness-to-donate-organs-among-people-living-with-hiv
#4
Anh Q Nguyen, Saad K Anjum, Samantha E Halpern, Komal Kumar, Sarah E Van Pilsum Rasmussen, Brianna Doby, Ashton A Shaffer, Allan B Massie, Aaron A R Tobian, Dorry L Segev, Jeremy Sugarman, Christine M Durand
BACKGROUND: With passage of the HIV Organ Policy Equity (HOPE) Act, people living with HIV (PLWH) can donate organs to PLWH awaiting transplant. Understanding knowledge and attitudes regarding organ donation among PLWH in the US is critical to implementing the HOPE Act. METHODS: PLWH were surveyed regarding their knowledge, attitudes, and beliefs about organ donation and transplantation at an urban academic HIV clinic in Baltimore, MD between 08/2016-10/2016. Responses were compared using Fisher's exact and chi-squared tests...
May 16, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29779980/risk-and-risk-factors-for-revision-after-primary-reverse-shoulder-arthroplasty-for-cuff-tear-arthropathy-and-osteoarthritis-a-nordic-arthroplasty-register-association-study
#5
Kaisa Lehtimäki, Jeppe V Rasmussen, Jari Mokka, Björn Salomonsson, Randi Hole, Steen Lund Jensen, Ville Äärimaa
BACKGROUND: Reverse shoulder arthroplasty (RSA) has gained increasing popularity in the treatment of rotator cuff tear arthropathy (CTA). The purpose of this study was to evaluate the survival of RSA and the risk factors for revision following RSA. METHODS: RSA patients with CTA or osteoarthritis were identified from the Nordic Arthroplasty Register Association registry data (2004-2013). Kaplan-Meier survival analysis was used to calculate survival probabilities...
May 17, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29775869/mathematics-intervention-for-children-with-fetal-alcohol-spectrum-disorder-a-replication-and-extension-of-the-math-interactive-learning-experience-mile-program
#6
Katrina Kully-Martens, Jacqueline Pei, Julie Kable, Claire D Coles, Gail Andrew, Carmen Rasmussen
BACKGROUND: Individuals with fetal alcohol spectrum disorders (FASD) experience deficits in behavior, cognition, and academic functioning resulting from prenatal alcohol exposure (PAE). Although receiving intervention for developmental disabilities is a strong protective factor against negative outcomes in FASD, intervention research in this population is in its infancy. AIMS: The purpose of this study was to replicate and extend a mathematics intervention, the Math Interactive Learning Experience (MILE) program, which was developed in the USA specifically for children with FASD...
May 15, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29775474/the-cryptococcus-neoformans-titan-cell-is-an-inducible-and-regulated-morphotype-underlying-pathogenesis
#7
Ivy M Dambuza, Thomas Drake, Ambre Chapuis, Xin Zhou, Joao Correia, Leanne Taylor-Smith, Nathalie LeGrave, Tim Rasmussen, Matthew C Fisher, Tihana Bicanic, Thomas S Harrison, Marcel Jaspars, Robin C May, Gordon D Brown, Raif Yuecel, Donna M MacCallum, Elizabeth R Ballou
Fungal cells change shape in response to environmental stimuli, and these morphogenic transitions drive pathogenesis and niche adaptation. For example, dimorphic fungi switch between yeast and hyphae in response to changing temperature. The basidiomycete Cryptococcus neoformans undergoes an unusual morphogenetic transition in the host lung from haploid yeast to large, highly polyploid cells termed Titan cells. Titan cells influence fungal interaction with host cells, including through increased drug resistance, altered cell size, and altered Pathogen Associated Molecular Pattern exposure...
May 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29775113/how-does-leadership-manifest-in-the-patient-therapist-interaction-among-physiotherapists-in-primary-health-care-a-qualitative-study
#8
Eva Rasmussen-Barr, Mairi Savage, Mia Von Knorring
OBJECTIVES: Health care is undergoing changes and this requires the participation and leadership of all health-care professions. While numerous studies have explored leadership competence among physicians and nurses, the physiotherapy profession has received but limited attention. The aim of this study was to explore how leadership manifests in the patient-therapist interaction among physiotherapists in primary health care and how the physiotherapists themselves relate their perception of leadership to their clinical practice...
May 18, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29773082/no-detectable-differential-microrna-expression-between-non-atherosclerotic-arteries-of-type-2-diabetic-patients-treated-or-untreated-with-metformin-and-non-diabetic-patients
#9
Lasse Bach Steffensen, Søren Feddersen, Simone Rørdam Preil, Lars Melholt Rasmussen
BACKGROUND: Type 2 diabetes mellitus (T2DM) is an independent risk factor of cardiovascular disease (CVD), however, the underlying mechanisms are largely unknown. Using non-atherosclerotic internal thoracic arteries (ITAs) obtained from coronary artery bypass grafting, we previously identified a distinct elevation in the level of proteins comprising the arterial basement membrane in T2DM patients not treated with metformin. Altered transcription of genes encoding these proteins has not been observed, indicating alternative mechanisms of dysregulation...
May 17, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29772738/angiogenesis-pet-tracer-uptake-68-ga-nodaga-e-crgdyk-%C3%A2-in-induced-myocardial-infarction-and-stromal-cell-treatment-in-minipigs
#10
Thomas Rasmussen, Bjarke Follin, Jens Kastrup, Malene Brandt-Larsen, Jacob Madsen, Thomas Emil Christensen, Morten Juhl, Smadar Cohen, Karsten Pharao Hammelev, Christian Holdflod Møller, Jens Peter Goetze, Philip Hasbak, Andreas Kjær
Angiogenesis is considered integral to the reparative process after ischemic injury. The αv β₃ integrin is a critical modulator of angiogenesis and highly expressed in activated endothelial cells. 68 Ga-NODAGA-E[(cRGDyK)]₂ (RGD) is a positron-emission-tomography (PET) ligand targeted towards αv β₃ integrin. The aim was to present data for the uptake of RGD and correlate it with histology and to further illustrate the differences in angiogenesis due to porcine adipose-derived mesenchymal stromal cell (pASC) or saline treatment in minipigs after induction of myocardial infarction (MI)...
May 16, 2018: Diagnostics
https://www.readbyqxmd.com/read/29772736/exploring-the-effect-of-phage-therapy-in-preventing-vibrio-anguillarum-infections-in-cod-and-turbot-larvae
#11
Nanna Rørbo, Anita Rønneseth, Panos G Kalatzis, Bastian Barker Rasmussen, Kirsten Engell-Sørensen, Hans Petter Kleppen, Heidrun Inger Wergeland, Lone Gram, Mathias Middelboe
The aquaculture industry is suffering from losses associated with bacterial infections by opportunistic pathogens. Vibrio anguillarum is one of the most important pathogens, causing vibriosis in fish and shellfish cultures leading to high mortalities and economic losses. Bacterial resistance to antibiotics and inefficient vaccination at the larval stage of fish emphasizes the need for novel approaches, and phage therapy for controlling Vibrio pathogens has gained interest in the past few years. In this study, we examined the potential of the broad-host-range phage KVP40 to control four different V...
May 16, 2018: Antibiotics
https://www.readbyqxmd.com/read/29770577/percutaneous-reduction-and-internal-fixation-for-monocondylar-fractures-of-tibial-plateau-a-systematic-review
#12
REVIEW
Heng-Rui Chang, Yi-Yang Yu, Lin-Lin Ju, Zhan-Le Zheng, Wei Chen, Ying-Ze Zhang
Instead of extensive dissection of soft tissue around the fracture site, percutaneous techniques have unique advantages in managing displaced fragments, including preservation of soft tissues, less blood loss, lower risk of complications, and earlier functional rehabilitation. However, there are few systematic reviews on the effects of percutaneous reduction and internal fixation (PRIF) for tibial plateau fractures. A systematic search of Cochrane, EMBASE, and MEDLINE databases was performed for all publicly available data in March 2017 regarding the use of PRIF in treating monocondylar tibial plateau fractures...
May 16, 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29767646/letter-to-the-editor-regarding-the-joint-statement-from-the-american-college-of-surgeons-committee-on-trauma-acs-cot-and-the-american-college-of-emergency-physicians-acep-regarding-the-clinical-use-of-resuscitative-endovascular-balloon-occlusion-of-the-aorta
#13
https://www.readbyqxmd.com/read/29764306/long-term-complications-of-appendectomy-a-systematic-review
#14
T Rasmussen, S Fonnes, J Rosenberg
BACKGROUND AND AIMS: Appendectomy is a common surgical procedure, but no overview of the long-term consequences exists. Our aim was to systematically review the long-term complications of appendectomy for acute appendicitis. MATERIALS AND METHODS: This systematic review was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A protocol was registered on PROSPERO (CRD42017064662). The databases PubMed and EMBASE were searched for original reports on appendectomy with n ≥ 500 and follow-up >30 days...
May 1, 2018: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/29761639/nongenetic-risk-factors-for-holoprosencephaly-an-updated-review-of-the-epidemiologic-literature
#15
April D Summers, Jennita Reefhuis, Joanna Taliano, Sonja A Rasmussen
Holoprosencephaly (HPE) is a major structural birth defect of the brain that occurs in approximately 1 in 10,000 live births. Although some genetic causes of HPE are known, a substantial proportion of cases have an unknown etiology. Due to the low birth prevalence and rarity of exposure to many potential risk factors for HPE, few epidemiologic studies have had sufficient sample size to examine risk factors. A 2010 review of the literature identified several risk factors that had been consistently identified as occurring more frequently among cases of HPE, including maternal diabetes, twinning, and a predominance of females, while also identifying a number of potential risk factors that had been less widely studied...
May 15, 2018: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/29760189/incidence-and-prevalence-of-sporadic-and-hereditary-mtc-in-denmark-1960-2014-a-nationwide-study
#16
Jes Sloth Mathiesen, Jens Peter Kroustrup, Peter Vestergaard, Kirstine Stochholm, Per Løgstrup Poulsen, Åse Krogh Rasmussen, Ulla Feldt-Rasmussen, Sten Schytte, Stefano Christian Londero, Henrik Baymler Pedersen, Christoffer Holst Hahn, Bjarki Ditlev Djurhuus, Jens Bentzen, Sören Möller, Mette Gaustadnes, Maria Rossing, Finn Cilius Nielsen, Kim Brixen, Anja Lisbeth Frederiksen, Christian Godballe
Recent studies have shown a significant increase in the temporal trend of medullary thyroid carcinoma (MTC) incidence. However, it remains unknown to which extent sporadic medullary thyroid carcinoma (SMTC) and hereditary MTC (HMTC) affects the MTC incidence over time. We conducted a nationwide retrospective study using previously described RET and MTC cohorts combined with review of medical records, pedigree comparison and relevant nationwide registries. The study included 474 MTC patients diagnosed in Denmark between 1960 and 2014...
May 14, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29759089/thrombocytopenia-in-bacteraemia-and-association-with-bacterial-species
#17
D Johansson, M Rasmussen, M Inghammar
Thrombocytopenia is common in patients with invasive bacterial infections. Bacteria can activate platelets, but it is unclear if this affects platelet count. The aim of this study was to examine whether bacteraemia with Staphylococcus aureus, which readily activate human platelets, was more likely to be complicated by thrombocytopenia than bacteraemia with Escherichia coli or Streptococcus pneumoniae with different abilities to activate platelets.We compared information from 600 adult patients with community-acquired bacteraemia with S...
May 15, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29758557/a-phenomenological-approach-to-psychopathology-of-imagination-development-of-a-descriptive-instrument-examination-of-anomalous-fantasy-and-imagination
#18
Andreas Rosén Rasmussen, Helene Stephensen, Julie Nordgaard, Josef Parnas
This paper serves as an introduction to the Examination of Anomalous Fantasy and Imagination (EAFI) - a novel instrument for a semistructured, phenomenological exploration of psychopathology of imagination. We present an account of the phenomenology of imagination and proceed to a presentation of the disorders of imagination that are addressed in the EAFI. Furthermore, the interrater reliability of the EAFI was examined in a diagnostically heterogeneous sample of 20 in-patients. The interrater agreement ranged from 0...
May 14, 2018: Psychopathology
https://www.readbyqxmd.com/read/29758549/eafi-examination-of-anomalous-fantasy-and-imagination
#19
Andreas Rosén Rasmussen, Helene Stephensen, Josef Parnas
The Examination of Anomalous Fantasy and Imagination (EAFI) is an instrument for a semistructured, phenomenological exploration of psychopathology of imagination. The EAFI provides a conceptual-descriptive framework to address such experiences. It consists of 16 main items, sometimes divided into subtypes. We suggest that the anomalies of imagination explored by the EAFI reflect an alteration in the structure of consciousness and belong to a fundamental, generative layer of psychopathology with relevance to differential diagnostic purposes...
May 14, 2018: Psychopathology
https://www.readbyqxmd.com/read/29757710/what-went-right-an-analysis-of-the-protective-factors-in-aviation-near-misses
#20
Brian Thoroman, Natassia Goode, Paul Salmon, Matthew Wooley
Learning from successful safety outcomes, or what went right, is an important emerging component of maintaining safe systems. Accordingly, there are increasing calls to study normal performance in near misses as part of safety management activities. Despite this, there is limited guidance on how to accomplish this in practice. This article presents a study in which using Rasmussen's risk management framework to analyse sixteen serious incidents from the aviation domain. The findings show that a network of protective factors prevents accidents with factors identified across the sociotechnical system...
May 14, 2018: Ergonomics
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