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https://www.readbyqxmd.com/read/28239546/functional-hemispherotomy-in-rasmussen-syndrome-in-the-absence-of-classic-mri-findings
#1
Yasunori Nagahama, Charuta Joshi, Brian Dlouhy, Angela Y Wu, Taylor J Abel, Gary Baumbach, Hiroto Kawasaki
A 7-year-old previously healthy girl presented with a left-sided focal seizure without impaired consciousness and subsequently developed epilepsia partialis continua. Initial MRI was normal, and the subsequent images only showed a focal T2/FLAIR hyperintense area without cortical atrophy. She was diagnosed with Rasmussen syndrome by pathology and promptly treated with functional hemispherotomy. Rasmussen syndrome is a rare progressive neurological disorder, the only definitive cure for which is hemispheric disconnection...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/28238106/a-critical-assessment-of-early-warning-score-records-in-168-000-patients
#2
Niels Egholm Pedersen, Lars Simon Rasmussen, John Asger Petersen, Thomas Alexander Gerds, Doris Østergaard, Anne Lippert
The national early warning score (NEWS) is recommended to detect deterioration in hospitalised patients. In 2013, a NEWS-based system was introduced in a hospital service with over 250,000 annual admissions, generating large amounts of NEWS data. The quality of such data has not been described. We critically assessed NEWS data recorded over 12 months. This observational study included NEWS records from adult inpatients hospitalized in the Capital Region of Denmark during 2014. Physiological variables and the use of supplementary oxygen (NEWS variables) were recorded...
February 25, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28238022/mapping-of-common-bunt-resistance-gene-bt9-in-wheat
#3
Philipp Matthias Steffan, Anna Maria Torp, Anders Borgen, Gunter Backes, Søren K Rasmussen
The Bt9 resistance locus was mapped and shown to be distinct from the Bt10 locus. New markers linked to Bt9 have been identified and may be used to breed for resistance towards the seed-borne disease. Increasing organic wheat production in Denmark, and in other wheat-producing areas, in conjunction with legal requirements for organic seed production, may potentially lead to a rise in common bunt occurrence. As systemic pesticides are not used in organic farming, organic wheat production systems may benefit from genetic resistances...
February 25, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28237919/the-relation-between-the-frequency-of-short-pulse-electrical-stimulation-of-afferent-nerve-fibers-and-evoked-muscle-force
#4
Jakob L Dideriksen, Kasper Leerskov, Magdalena Czyzewska, Rune Rasmussen
OBJECTIVE: Functional electrical stimulation (FES) is conventionally performed by the stimulation of motor axons causing the muscle fibers innervated by these axons to contract. An alternative strategy that may evoke contractions with more natural motor unit behavior is to stimulate afferent fibers (primarily type Ia) to excite the motor neurons at the spinal level. The aim of the study was to investigate the range of forces that can be evoked in this way and the degree to which the torque can be controlled...
February 20, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28237510/retrospective-evaluation-of-a-national-guideline-to-prevent-neonatal-hypoglycemia
#5
Annett Helleskov Rasmussen, Sonja Wehberg, Jesper Fenger-Groen, Henrik Thybo Christesen
BACKGROUND: Hypoglycemia is common in neonates and may cause adverse neurological outcomes. Guidelines should aim to prevent repeated hypoglycemic episodes in risk groups, but they are not usually stratified according to the severity of hypoglycemia risk, which may lead to inappropriate and redundant interventions. We evaluated the effect of a national prevention guideline stratified according to mild, moderate, and severe risks of hypoglycemia. METHODS: From national registers, a population cohort of 22,725 neonates was identified retrospectively before and after implementation of a national guideline...
January 24, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28237333/presence-and-localization-of-bacteria-in-the-bovine-endometrium-postpartum-using-fluorescence-in-situ-hybridization
#6
C C Karstrup, J S Agerholm, T K Jensen, L R V Swaro, K Klitgaard, E L Rasmussen, K M Krogh, H G Pedersen
The aim of this study was to investigate bacterial invasiveness of the bovine endometrium during the postpartum period. Fluorescence in situ hybridization was applied to endometrial biopsies using probes for Fusobacterium necrophorum, Porphyromonas levii, Trueperella pyogenes, Escherichia coli and a probe for bacteria in general (the overall domain Bacteria) to determine their tissue localization. Holstein cows were sampled at three time points postpartum (T1: 4-12 days postpartum, T2: 24-32 days postpartum and T3: 46-54 days postpartum)...
April 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28236063/finding-of-idh1-r132h-mutation-in-histologically-non-neoplastic-glial-tissue-changes-surgical-strategies-a-case-report
#7
Christian Baastrup Søndergaard, David Scheie, Astrid Marie Sehested, Jane Skjøth-Rasmussen
INTRODUCTION: In 2016, the WHO classification of diffuse astrocytoma began to include isocitrate dehydrogenase (IDH) mutation in addition to histology. RESULTS: We here demonstrate a case where a 14-year-old boy presented with a parietal tumor with no histological evidence of neoplasia but with an IDH1 mutation. Due to the IDH1 R132H mutation, the patient was diagnosed with diffuse astrocytoma WHO grade II and underwent successful gross total resection of this near-eloquently located tumor...
February 24, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28235764/cellular-and-molecular-identity-of-tumor-associated-macrophages-in-glioblastoma
#8
Zhihong Chen, Xi Feng, Cameron J Herting, Virginia Alvarez Garcia, Kai Nie, Winnie W Pong, Rikke Rasmussen, Bhakti Dwivedi, Sandra Seby, Susanne A Wolf, David H Gutmann, Dolores Hambardzumyan
In glioblastoma (GBM), tumor--associated macrophages (TAM) represent up to one half of the cells of the tumor mass, including both infiltrating macrophages and resident brain microglia. In an effort to delineate the temporal and spatial dynamics of TAM composition during gliomagenesis, we employed two genetically engineered mouse models where oncogenic drivers and fluorescent reporters were expressed coordinately under the control of the monocyte/microglia--selective Cx3cr1 or Ccr2 promoters, respectively. Using this approach, we demonstrated that CX3CR1LoCCR2Hi monocytes were recruited to the glioblastoma, where they transitioned to CX3CR1HiCCR2Lo macrophages and CX3CR1HiCCR2- microglia--like cells...
February 24, 2017: Cancer Research
https://www.readbyqxmd.com/read/28231450/protein-networks-in-alzheimer-s-disease
#9
Eva Meier Carlsen, Rune Rasmussen
Overlap of RNA and protein networks reveals glia cells as key players for the development of symptomatic Alzheimer's disease in humans.
February 22, 2017: Cell Systems
https://www.readbyqxmd.com/read/28230048/differential-regulation-of-the-epr3-receptor-coordinates-membrane-restricted-rhizobial-colonization-of-root-nodule-primordia
#10
Yasuyuki Kawaharada, Mette W Nielsen, Simon Kelly, Euan K James, Kasper R Andersen, Sheena R Rasmussen, Winnie Füchtbauer, Lene H Madsen, Anne B Heckmann, Simona Radutoiu, Jens Stougaard
In Lotus japonicus, a LysM receptor kinase, EPR3, distinguishes compatible and incompatible rhizobial exopolysaccharides at the epidermis. However, the role of this recognition system in bacterial colonization of the root interior is unknown. Here we show that EPR3 advances the intracellular infection mechanism that mediates infection thread invasion of the root cortex and nodule primordia. At the cellular level, Epr3 expression delineates progression of infection threads into nodule primordia and cortical infection thread formation is impaired in epr3 mutants...
February 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28229827/anti-la-positive-anti-ro-negative-subset-of-primary-sj%C3%A3-gren-s-syndrome-anti-la-is-a-reality-but-is-the-disease
#11
Debashish Danda, Rohan Sharma, Dat Truong, Kristi A Koelsch, Biji T Kurien, Harini Bagavant, Umesh Deshmukh, C Erick Kaufman, David M Lewis, Donald U Stone, Lida Radfar, Astrid Rasmussen, Kathy L Sivils, Robert H Scofield
OBJECTIVES: To characterise the serological and clinical findings in primary Sjögren's syndrome in which anti-La was found without anti-Ro. We hypothesised that a significant portion of these are falsely negative for anti-Ro60. METHODS: Twenty-nine sera from primary Sjögren's syndrome patients were tested for antibodies directed against La and Ro. Anti-La was detected using bovine La treated with or without DNAase and RNAase to identify potential false positivity...
February 20, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28228060/resuscitation-with-lyophilized-plasma-is-safe-and-improves-neurologic-recovery-in-a-long-term-survival-model-of-swine-subjected-to-traumatic-brain-injury-hemorrhagic-shock-and-polytrauma
#12
Patrick E Georgoff, Vahagn C Nikolian, Ihab Halaweish, Kiril Chtraklin, Peter J Bruhn, Hassan Eidy, Monica Rasmussen, Yongqing Li, Ashok Srinivasan, Hasan B Alam
We have previously shown that fresh frozen plasma (FFP) and lyophilized plasma decrease brain lesion size and improve neurologic recovery in a swine model of traumatic brain injury (TBI) and hemorrhagic shock (HS). In this study, we examine whether these findings can be validated in a clinically relevant model of severe TBI, HS, and polytrauma. Female Yorkshire swine were subjected to TBI (controlled cortical impact), hemorrhage (40% volume), grade III liver and splenic injuries, rib fracture, and rectus abdominis crush...
February 22, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28225014/corrigendum-glomerular-filtration-rate-in-patients-with-atrial-fibrillation-and-1-year-outcomes
#13
Giuseppe Boriani, Cécile Laroche, Igor Diemberger, Mircea Ioachim Popescu, Lars Hvilsted Rasmussen, Lucian Petrescu, Harry J G M Crijns, Luigi Tavazzi, Aldo P Maggioni, Gregory Y H Lip
No abstract text is available yet for this article.
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28224985/episodic-release-of-co2-from-the-high-latitude-north-atlantic-ocean-during-the-last-135%C3%A2-kyr
#14
Mohamed M Ezat, Tine L Rasmussen, Bärbel Hönisch, Jeroen Groeneveld, Peter deMenocal
Antarctic ice cores document glacial-interglacial and millennial-scale variability in atmospheric pCO2 over the past 800 kyr. The ocean, as the largest active carbon reservoir on this timescale, is thought to have played a dominant role in these pCO2 fluctuations, but it remains unclear how and where in the ocean CO2 was stored during glaciations and released during (de)glacial millennial-scale climate events. The evolution of surface ocean pCO2 in key locations can therefore provide important clues for understanding the ocean's role in Pleistocene carbon cycling...
February 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28223847/evaluation-of-icd-10-algorithms-to-identify-hypopituitary-patients-in-the-danish-national-patient-registry
#15
Agnethe Berglund, Morten Olsen, Marianne Andersen, Eigil Husted Nielsen, Ulla Feldt-Rasmussen, Caroline Kistorp, Claus Højbjerg Gravholt, Kirstine Stochhholm
OBJECTIVE: Routinely collected health data may be valuable sources for conducting research. This study aimed to evaluate the validity of algorithms detecting hypopituitary patients in the Danish National Patient Registry (DNPR) using medical records as reference standard. STUDY DESIGN AND SETTING: Patients with International Classification of Diseases (10th edition [ICD-10]) diagnoses of hypopituitarism, or other diagnoses of pituitary disorders assumed to be associated with an increased risk of hypopituitarism, recorded in the DNPR during 2000-2012 were identified...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28222112/genome-wide-study-of-resistant-hypertension-identified-from-electronic-health-records
#16
Logan Dumitrescu, Marylyn D Ritchie, Joshua C Denny, Nihal M El Rouby, Caitrin W McDonough, Yuki Bradford, Andrea H Ramirez, Suzette J Bielinski, Melissa A Basford, High Seng Chai, Peggy Peissig, David Carrell, Jyotishman Pathak, Luke V Rasmussen, Xiaoming Wang, Jennifer A Pacheco, Abel N Kho, M Geoffrey Hayes, Martha Matsumoto, Maureen E Smith, Rongling Li, Rhonda M Cooper-DeHoff, Iftikhar J Kullo, Christopher G Chute, Rex L Chisholm, Gail P Jarvik, Eric B Larson, David Carey, Catherine A McCarty, Marc S Williams, Dan M Roden, Erwin Bottinger, Julie A Johnson, Mariza de Andrade, Dana C Crawford
Resistant hypertension is defined as high blood pressure that remains above treatment goals in spite of the concurrent use of three antihypertensive agents from different classes. Despite the important health consequences of resistant hypertension, few studies of resistant hypertension have been conducted. To perform a genome-wide association study for resistant hypertension, we defined and identified cases of resistant hypertension and hypertensives with treated, controlled hypertension among >47,500 adults residing in the US linked to electronic health records (EHRs) and genotyped as part of the electronic MEdical Records & GEnomics (eMERGE) Network...
2017: PloS One
https://www.readbyqxmd.com/read/28221318/evaluating-and-treating-mammalian-bites
#17
Donna Rasmussen, Alexandra Landon, Jennifer Powell, Gina R Brown
Mammalian bites, typically from dogs, cats, or humans, are a common presentation in EDs and family practice settings, and patients present with varying degrees of complexity. Injuries can range from local to systemic, including aggressive bacterial infections and permanent limb impairment. Using a systematic approach to initial wound assessment, followed by appropriate diagnostic testing and treatment, is critical to improved long-term patient outcomes.
March 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28220591/transcriptome-analysis-of-root-knot-nematode-meloidogyne-incognita-infected-tomato-solanum-lycopersicum-roots-reveals-complex-gene-expression-profiles-and-metabolic-networks-of-both-host-and-nematode-during-susceptible-and-resistance-responses
#18
Neha Shukla, Rachita Yadav, Pritam Kaur, Simon Rasmussen, Shailendra Goel, Manu Agarwal, Arun Jagannath, Ramneek Gupta, Amar Kumar
Root knot nematodes (RKNs, Meloidogyne incognita) are economically important endoparasites having a wide-host range. We have taken a comprehensive transcriptomic approach to investigate the expression of both tomato and RKN genes in tomato roots at five infection time intervals from susceptible plants and two infection time intervals from resistant plants, grown under soil conditions. Differentially expressed genes during susceptible (1827-tomato, 462-RKN) and resistance (25-tomato, 160-RKN) interactions were identified...
February 21, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/28220437/chitin-induced-responses-in-the-moss-physcomitrella-patens
#19
Simon Bressendorff, Magnus Wohlfahrt Rasmussen, Morten Petersen, John Mundy
A MAP kinase pathway below a chitin receptor in the moss Physcomitrella patens induces immune responses including rapid growth inhibition, a novel fluorescence burst, and cell wall depositions. The molecular mechanisms producing these three responses are currently unknown but warrant further investigation in this simple model system. Here we describe qualitative, time-lapse, and quantitative assays to monitor and measure these responses.
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28218559/a-scandcleft-randomised-trials-of-primary-surgery-for-unilateral-cleft-lip-and-palate-1-planning-and-management
#20
Gunvor Semb, Hans Enemark, Hans Friede, Gunnar Paulin, Jan Lilja, Jorma Rautio, Mikael Andersen, Frank Åbyholm, Anette Lohmander, William Shaw, Kirsten Mølsted, Arja Heliövaara, Stig Bolund, Jyri Hukki, Hallvard Vindenes, Peter Davenport, Kjartan Arctander, Ola Larson, Anders Berggren, David Whitby, Alan Leonard, Erik Neovius, Anna Elander, Elisabeth Willadsen, R Patricia Bannister, Eileen Bradbury, Gunilla Henningsson, Christina Persson, Philip Eyres, Berit Emborg, Mia Kisling-Møller, Annelise Küseler, Birthe Granhof Black, Antje Schöps, Anja Bau, Maria Boers, Helene Søgaard Andersen, Karin Jeppesen, Dorte Marxen, Marjukka Paaso, Elina Hölttä, Suvi Alaluusua, Leena Turunen, Kirsti Humerinta, Ulla Elfving-Little, Inger Beate Tørdal, Lillian Kjøll, Ragnhild Aukner, Øydis Hide, Kristin Billaud Feragen, Elisabeth Rønning, Pål Skaare, Eli Brinck, Ann-Magritt Semmingsen, Nina Lindberg, Melanie Bowden, Julie Davies, Jeanette Mooney, Haydn Bellardie, Nina Schofield, Jill Nyberg, Maria Lundberg, Agneta Linder-Aronson Karsten, Margareta Larson, Anders Holmefjord, Sigvor Reisæter, Nina-Helen Pedersen, Therese Rasmussen, Rolf Tindlund, Paul Sæle, Reidunn Blomhoff, Gry Jacobsen, Christina Havstam, Sara Rizell, Lars Enocson, Catharina Hagberg, Midia Najar Chalien, Anna Paganini, Inger Lundeborg, Agneta Marcusson, Anna-Britta Mjönes, Annica Gustavsson, Christine Hayden, Eilish McAleer, Emma Slevan, Terry Gregg, Helen Worthington
BACKGROUND AND AIMS: Longstanding uncertainty surrounds the selection of surgical protocols for the closure of unilateral cleft lip and palate, and randomised trials have only rarely been performed. This paper is an introduction to three randomised trials of primary surgery for children born with complete unilateral cleft lip and palate (UCLP). It presents the protocol developed for the trials in CONSORT format, and describes the management structure that was developed to achieve the long-term engagement and commitment required to complete the project...
February 2017: Journal of Plastic Surgery and Hand Surgery
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