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Daniel Berglind, Lena Hansson, Per Tynelius, Finn Rasmussen
BACKGROUND: Levels of physical activity (PA) affect health already at four years of age. The aims of this study were to describe levels and patterns of PA and sedentary time (ST) in a sample of four-year-old Swedish children and to assess the number of children achieving PA guidelines throughout the week. METHODS: Data from 540 four-year old children enrolled in the population-based PRIMROSE trial was used. PA was measured for a period of one week by the Actigraph GT3X+ accelerometer...
October 24, 2016: Journal of Physical Activity & Health
Salwa El Tawil, Robin Morris, Nandini Mullatti, Lina Nashef, Sanjeev Rajakulendran
No abstract text is available yet for this article.
September 28, 2016: Seizure: the Journal of the British Epilepsy Association
Gaige R VandeZande, Jasmine M Olvany, Julia L Rutherford, Michelle Rasmussen
Enzymatic electrodes are becoming increasingly common for energy production and sensing applications. Research over the past several decades has addressed a major issue that can occur when using these biocatalysts, i.e., slow heterogeneous electron transfer, by incorporation of a redox active species to act as an electron shuttle. There are several advantages to immobilizing both the enzyme and mediator at the enzyme surface, including increased electron transfer rates, decreased enzyme leaching, and minimized diffusion limitations...
2017: Methods in Molecular Biology
Sankar Neelakantan, Rakesh Anandarajan, Anil Kumar Swamy
No abstract text is available yet for this article.
October 21, 2016: BMJ Case Reports
R Tom Liu, Lucy Goold, Valerie A White, Steve Rasmussen, Vivian T Yin
No abstract text is available yet for this article.
October 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
A K Singh, Varun Gupta, Bindu Rani, Manish Kumar, Saurabh Kaushik
Angiographic findings in tuberculosis patients presenting with hemoptysis include hypervascularity, hypertrophy of systemic arteries, aneurysm, systemic to pulmonary anastomosis, and rarely, contrast extravasation. Bronchial arteries are the source of hemorrhage in majority of cases with non-bronchial systemic or pulmonary arteries being less common as the source. Rasmussen's Aneurysm is a very rare sequalae of Pulmonary Tuberculosis. We present one such case of Rasmussen's aneurysm and review of the relevant literature...
October 2016: Journal of the Association of Physicians of India
Mikkel Staberg, Signe Regner Michaelsen, Rikke Darling Rasmussen, Mette Villingshøj, Hans Skovgaard Poulsen, Petra Hamerlik
PURPOSE: Glioblastoma (GBM) ranks among the deadliest solid cancers worldwide and its prognosis has remained dismal, despite the use of aggressive chemo-irradiation treatment regimens. Limited drug delivery into the brain parenchyma and frequent resistance to currently available therapies are problems that call for a prompt development of novel therapeutic strategies. While only displaying modest efficacies as mono-therapy in pre-clinical settings, histone deacetylase inhibitors (HDACi) have shown promising sensitizing effects to a number of cytotoxic agents...
October 20, 2016: Cellular Oncology (Dordrecht)
Patrick Waterson, Jean-Christophe Le Coze, Henning Boje Andersen
No abstract text is available yet for this article.
October 17, 2016: Applied Ergonomics
Benjamin Bohman, Finn Rasmussen, Ata Ghaderi
BACKGROUND: Parental self-efficacy (PSE) refers to beliefs of parents to effectively engage in behaviors that result in desired outcomes for their children. There are several instruments of PSE for promoting healthy dietary or physical activity (PA) behaviors in children. These measures typically assess PSE in relation to some quantity or frequency of behavior, for example, number of servings or times per week. However, measuring PSE in relation to contextual circumstances, for example, psychological states and situational demands, may be a more informative approach...
October 20, 2016: International Journal of Behavioral Nutrition and Physical Activity
Raul I Garcia, Tamanna Tiwari, Francisco Ramos-Gomez, Brenda Heaton, Mario Orozco, Margaret Rasmussen, Patricia Braun, Michelle Henshaw, Belinda Borrelli, Judith Albino, Courtney Diamond, Christina Gebel, Terrence S Batliner, Judith C Barker, Steven Gregorich, Stuart A Gansky
OBJECTIVES: To identify successful strategies for retention of participants in multiyear, community-based randomized controlled trials (RCTs) aiming to reduce early childhood caries in health disparities populations from diverse racial/ethnic backgrounds and across diverse geographic settings. METHODS: Four RCTs conducted by the Early Childhood Caries Collaborating Centers (EC4), an initiative of the National Institute of Dental and Craniofacial Research, systematically collected information on the success of various strategies implemented to promote participant retention in each RCT...
October 19, 2016: Journal of Public Health Dentistry
Mie Rostved Rasmussen, Kirstine Lykke Nielsen, Mia Roest Laursen, Camilla Bak Nielsen, Pia Svendsen, Henrik Dimke, Erik Ilsø Christensen, Mogens Johannsen, Søren Kragh Moestrup
Loss-of-function mutations in the transmembrane ABCC6 transport protein cause pseudoxanthoma elasticum - an ectopic, metabolic mineralization disorder affecting the skin, eye and vessels. ABCC6 is assumed to mediate efflux of one or several small molecule compounds from the liver cytosol to the circulation. Untargeted metabolomics using liquid chromatography mass spectrometry was employed to inspect liver cytosolic extracts from mice with targeted disruption of the Abcc6 gene. Absence of the ABCC6 protein induced an altered profile of metabolites in the liver causing accumulation of compounds as more features were upregulated than downregulated in ABCC6-deficient mice...
October 19, 2016: Journal of Proteome Research
Florian Leplat, Pai Rosager Pedas, Søren Kjærsgaard Rasmussen, Søren Husted
No abstract text is available yet for this article.
October 18, 2016: BMC Genomics
Matthias Peter Hilty, Andrea Müller, Daniela Flück, Christoph Siebenmann, Peter Rasmussen, Stefanie Keiser, Katja Auinger, Carsten Lundby, Marco Maggiorini
: Matthias Peter Hilty, Andrea Mueller, Daniela Flück, Christoph Siebenmann, Peter Rasmussen, Stefanie Keiser, Katja Auinger, Carsten Lundby, and Marco Maggiorini. Effect of increased blood flow on the pulmonary circulation before and during high altitude acclimatization. High Alt Med Biol. 00:000-000, 2016.-Introduction and Methods: Acute exposure to high altitude increases pulmonary artery pressure (Ppa) and pulmonary vascular resistance (PVR). The evolution of Ppa and PVR with continuous hypoxic exposure remains, however, elusive...
October 18, 2016: High Altitude Medicine & Biology
Anders F Frellsen, Anders E Hansen, Rasmus I Jølck, Paul Kempen, Gregory W Severin, Palle H Rasmussen, Andreas Kjær, Andreas T I Jensen, Thomas L Andresen
By taking advantage of the ability of (64)Cu to bind non-specifically to gold surfaces, we have developed a new methodology to embed this radionuclide inside gold nanoparticles (AuNPs). (64)Cu enables the in vivo imaging of AuNPs by positron emission tomography (PET). AuNPs have a multitude of uses within health technology and are useful tools for general nanoparticle research. (64)Cu-AuNPs were prepared by incubating AuNP seeds with (64)Cu(2+), followed by the entrapment of the radionuclide by grafting a second layer of gold on the surface...
October 18, 2016: ACS Nano
Y K Lyauk, C Stage, T K Bergmann, L Ferrero-Milliani, D Bjerre, R Thomsen, K P Dalhoff, H B Rasmussen, G Jürgens
The aim of this study was to identify demographic and genetic factors that significantly affect methylphenidate (MPH) pharmacokinetics (PK), and may help explain interindividual variability and further increase the safety of MPH. d-MPH plasma concentrations, demographic covariates, and carboxylesterase 1 (CES1) genotypes were gathered from 122 healthy adults and analyzed using nonlinear mixed effects modeling. The structural model that best described the data was a two-compartment disposition model with absorption transit compartments...
October 18, 2016: Clinical and Translational Science
Michael Olsen, Sara Greve, Marie Blicher, Ruan Kruger, Thomas Sehestedt, Susanne Rasmussen, Julie Vishram, Pierre Boutouyrie, Stephane Laurent
OBJECTIVE: Carotid-femoral pulse wave velocity (cfPWV) adds significantly to traditional cardiovascular (CV) risk prediction, but is not widely available. Therefore, it would be helpful if cfPWV could be replaced by an estimated carotid-femoral pulse wave velocity (ePWV) using age and mean blood pressure and previously published equations. The aim of this study was to investigate whether ePWV could predict CV events independently of traditional cardiovascular risk factors and/or cfPWV...
September 2016: Journal of Hypertension
M B Madsen, L J A Kogelman, H N Kadarmideen, H B Rasmussen
Selective serotonin reuptake inhibitors (SSRIs) are the most widely used antidepressants, but the efficacy of the treatment varies significantly among individuals. It is believed that complex genetic mechanisms play a part in this variation. We have used a network based approach to unravel the involved genetic components. Moreover, we investigated the potential difference in the genetic interaction networks underlying SSRI treatment response over time. We found four hub genes (ASCC3, PPARGC1B, SCHIP1 and TMTC2) with different connectivity in the initial SSRI treatment period (baseline to week 4) compared with the subsequent period (4-8 weeks after initiation), suggesting that different genetic networks are important at different times during SSRI treatment...
October 18, 2016: Pharmacogenomics Journal
Søren Due Andersen, Torben Bjerregaard Larsen, Anders Gorst-Rasmussen, Yousef Yavarian, Gregory Y H Lip, Flemming W Bach
BACKGROUND: Nearly one in 5 patients with ischemic stroke will invariably experience a second stroke within 5 years. Stroke risk stratification schemes based solely on clinical variables perform only modestly in non-atrial fibrillation (AF) patients and improvement of these schemes will enhance their clinical utility. Cerebral white matter hyperintensities are associated with an increased risk of incident ischemic stroke in the general population, whereas their association with the risk of ischemic stroke recurrence is more ambiguous...
October 18, 2016: Cerebrovascular Diseases
Tyler P Rasmussen, Prashant D Bhave
No abstract text is available yet for this article.
September 2016: Journal of Thoracic Disease
Bart B L Groen, Astrid M Horstman, Henrike M Hamer, Michiel de Haan, Janneau van Kranenburg, Jörgen Bierau, Martijn Poeze, Will K W H Wodzig, Blake B Rasmussen, Luc J C van Loon
CONTEXT: Skeletal muscle protein synthesis is highly responsive to food intake. It has been suggested that the post-prandial increase in circulating insulin modulates the muscle protein synthetic response to feeding. OBJECTIVE: To investigate whether a greater post-prandial rise in circulating insulin level increases amino acid uptake in muscle and augments post-prandial muscle protein synthesis rates. PARTICIPANTS: and design. 48 healthy young (age 22±1 y; BMI 22...
July 19, 2016: Journal of Clinical Endocrinology and Metabolism
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