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https://www.readbyqxmd.com/read/29777404/randomized-trial-comparing-resection-of-primary-tumor-with-no-surgery-in-stage-iv-breast-cancer-at-presentation-protocol-mf07-01
#1
Atilla Soran, Vahit Ozmen, Serdar Ozbas, Hasan Karanlik, Mahmut Muslumanoglu, Abdullah Igci, Zafer Canturk, Zafer Utkan, Cihangir Ozaslan, Turkkan Evrensel, Cihan Uras, Erol Aksaz, Aykut Soyder, Umit Ugurlu, Cavit Col, Neslihan Cabioglu, Betül Bozkurt, Ali Uzunkoy, Neset Koksal, Bahadir M Gulluoglu, Bulent Unal, Can Atalay, Emin Yıldırım, Ergun Erdem, Semra Salimoglu, Atakan Sezer, Ayhan Koyuncu, Gunay Gurleyik, Haluk Alagol, Nalan Ulufi, Uğur Berberoglu, Mustafa Dulger, Omer Cengiz, Efe Sezgin, Ronald Johnson
BACKGROUND: The MF07-01 trial is a multicenter, phase III, randomized, controlled study comparing locoregional treatment (LRT) followed by systemic therapy (ST) with ST alone for treatment-naïve stage IV breast cancer (BC) patients. METHODS: At initial diagnosis, patients were randomized 1:1 to either the LRT or ST group. All the patients were given ST either immediately after randomization or after surgical resection of the intact primary tumor. RESULTS: The trial enrolled 274 patients: 138 in the LRT group and 136 in the ST group...
May 17, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29777340/2017-update-of-the-turkish-league-against-rheumatism-tlar-evidence-based-recommendations-for-the-management-of-knee-osteoarthritis
#2
REVIEW
Tiraje Tuncer, Fatih Hasan Cay, Lale Altan, Gulcan Gurer, Cahit Kacar, Suheda Ozcakir, Sahap Atik, Figen Ayhan, Berrin Durmaz, Nurten Eskiyurt, Hakan Genc, Yesim GokceKutsal, Rezzan Gunaydin, Simin Hepguler, Sami Hizmetli, Taciser Kaya, Yesim Kurtais, Merih Saridogan, Dilsad Sindel, Serap Sutbeyaz, Omer Faruk Sendur, Hatice Ugurlu, Zeliha Unlu
In a Turkish League Against Rheumatism (TLAR) project, evidence-based recommendations for the management of knee osteoarthritis (OA) was developed for the first time in our country in 2012 (TLAR-2012). In accordance with developing medical knowledge and scientific evidence, recommendations were updated. The committee was composed of 22 physical medicine and rehabilitation specialists (4 have rheumatology subspeciality also) and an orthopaedic surgeon. Systematic literature search were applied on Pubmed, Embase, Cochrane and Turkish Medical Index for the dates between January the 1st 2012 and January the 29th of 2015...
May 17, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29777263/folate-treatment-of-pregnant-rat-dams-abolishes-metabolic-effects-in-female-offspring-induced-by-a-paternal-pre-conception-unhealthy-diet
#3
Jian Li, Yong-Ping Lu, Oleg Tsuprykov, Ahmed A Hasan, Christoph Reichetzeder, Mei Tian, Xiao Li Zhang, Qin Zhang, Guo-Ying Sun, Jingli Guo, Mohamed M S Gaballa, Xiao-Ning Peng, Ge Lin, Berthold Hocher
AIMS/HYPOTHESIS: Paternal high-fat diet prior to mating programmes impaired glucose tolerance in female offspring. We examined whether the metabolic consequences in offspring could be abolished by folate treatment of either the male rats before mating or the corresponding female rats during pregnancy. METHODS: Male F0 rats were fed either control diet or high-fat, high-sucrose and high-salt diet (HFSSD), with or without folate, before mating. Male rats were mated with control-diet-fed dams...
May 18, 2018: Diabetologia
https://www.readbyqxmd.com/read/29775153/feasibility-safety-and-changes-in-systolic-blood-pressure-associated-with-endovascular-revascularization-of-symptomatic-and-chronically-occluded-cervical-internal-carotid-artery-using-a-newly-suggested-radiographic-classification-of-chronically-occluded-cervical
#4
David Hasan, Mario Zanaty, Robert M Starke, Elias Atallah, Nohra Chalouhi, Pascal Jabbour, Amit Singla, Waldo R Guerrero, Daichi Nakagawa, Edgar A Samaniego, Nnenna Mbabuike, Rabih G Tawk, Adnan H Siddiqui, Elad I Levy, Roberta L Novakovic, Jonathan White, Clemens M Schirmer, Thomas G Brott, Hussain Shallwani, L Nelson Hopkins
OBJECTIVE The overall risk of ischemic stroke from a chronically occluded internal carotid artery (COICA) is around 5%-7% per year despite receiving the best available medical therapy. Here, authors propose a radiographic classification of COICA that can be used as a guide to determine the technical success and safety of endovascular recanalization for symptomatic COICA and to assess the changes in systemic blood pressure following successful revascularization. METHODS The radiographic images of 100 consecutive subjects with COICA were analyzed...
May 18, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29774768/the-effects-of-boswellia-serrata-gum-resin-on-the-blood-glucose-and-lipid-profile-of-diabetic-patients-a-double-blind-randomized-placebo-controlled-clinical-trial
#5
Saeed Mehrzadi, Bahreh Tavakolifar, Hasan Fallah Huseini, Seyed Hamdollah Mosavat, Mojtaba Heydari
Regarding preclinical evidence for antidiabetic effects of Boswellia serrata, we evaluated antihyperglycemic and lipid-lowering effects of Boswellia serrata gum resin in type 2 diabetic patients. Fifty-six diabetic patients were randomly allocated to 2 groups to receive 250 mg of the Boswellia serrata gum resin or placebo twice daily for 8 weeks in addition to their routine antidiabetic treatments. Although there was a considerable reduction after the intervention in the field of fasting blood sugar, glycosylated hemoglobin, and triglyceride in the Boswellia serrata gum resin group, no significant difference was observed in all outcome measures between the 2 groups at the end of the study...
January 2018: Journal of evidence-based integrative medicine
https://www.readbyqxmd.com/read/29774109/sik2-attenuates-proliferation-and-survival-of-breast-cancer-cells-with-simultaneous-perturbation-of-mapk-and-pi3k-akt-pathways
#6
Neslihan Zohrap, Özge Saatci, Burcak Ozes, Ipek Coban, Hasan Murat Atay, Esra Battaloglu, Özgür Şahin, Kuyas Bugra
Salt Inducible Kinase2 (SIK2) has been shown to contribute to tumorigenesis in multiple tumor types in a dichotomous manner. However, little is known about its contribution to breast malignancies. Here, we report SIK2 as a potential tumor suppressor in breast cancer whose expression was reduced in tumor tissues and breast cancer cell lines compared to normal counterparts. In vitro loss- and gain-of-function experiments combined with xenograft studies demonstrated that SIK2-mediated attenuation of proliferation and survival of breast cancer cells with parallel inhibition of both Ras/Erk and PI3K/Akt pathways...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29772315/long-term-durability-of-infrainguinal-endovascular-and-open-revascularization-for-disabling-claudication
#7
Sikandar Z Khan, Mariel Rivero, Gregory S Cherr, Linda M Harris, Maciej L Dryjski, Hasan H Dosluoglu
OBJECTIVE: Infrainguinal revascularization for disabling claudication (DC) is frequently performed but long term results are still unknown. In this study, we compared clinical outcomes of infrainguinal endovascular (EV) and open interventions for DC following failure of medical management. METHODS: 194 patients with DC (Rutherford category 3) who had open (n=53) or EV (n=141) interventions were grouped as Open-GSV (n=21), Open-Prosthetic (n=32), EV- AB (TASCII A & B) (n=48) and EV-CD (TASCII C & D) (n=93)...
May 14, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29771707/electrolytes-and-biochemical-changes-in-cerebrospinal-fluid-in-drowning-experimental-rabbit-model
#8
Melad G Paulis, Eman I Hasan
The diagnosis of drowning is still a difficult task in forensic science. Biochemical changes in different body fluids have been examined for the identification of drowning. However, none of them alone gives accurate results in the diagnosis of drowning and differentiation of saltwater and freshwater drowning. This study aimed to examine cerebrospinal fluid changes in drowned rabbits. Six groups of rabbits were used including immersed dead rabbits in freshwater or saltwater (as control groups), alive fully conscious rabbits drowned in freshwater and saltwater, and anesthetized rabbits drowned in freshwater and saltwater...
May 15, 2018: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/29769515/complications-following-general-anaesthesia-in-paediatric-patients
#9
A K Khan, S R Quddus, H K Khan, M S Ali, M Kamruzzaman, M R Hasan, M Hasan, R H Moon
Complications in paediatric anaesthesia can be conveniently classified as minor or major. Major morbidity includes cardiac arrest, brain damage and death. Minor morbidity can be assessed by clinical audits with smell patient samples. Major morbidity is rare. It is best assessed by very large clinical studies and by review of cases malpractice claims. Both minor & major complication occurs most commonly in infants and children under three especially those with severe co-morbidities. Knowledge of risk profiles in paediatric anaesthesia is a starting point for the reduction of risk complication...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29769503/vitamin-d-status-in-newly-diagnosed-type-2-diabetes-patients-attending-in-a-tertiary-hospital-of-bangladesh
#10
M S Alam, M Kamrul-Hasan, S T Kalam, S Selim, F Akter, M Saifuddin
Vitamin D deficiency is common in patients with type 2 diabetes mellitus (T2DM). Vitamin D status may have a causal role in the onset of T2DM and may influence glycaemic control in these patients. However, data on vitamin D status among Bangladeshi T2DM patients are scarce. The present cross-sectional study was done among newly diagnosed 50 T2DM patients attending outpatient department of Comilla Diabetic Hospital, Bangladesh to address this lacuna. Serum 25(OH)D was measured in all and classified as normal (≥30ng/mL), insufficient (>20 to 29...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29769486/low-free-t%C3%A2-was-associated-with-poor-glycemic-control-in-type-2-diabetes-in-a-hospital-based-study-in-bangladesh
#11
M Kamrul-Hasan, N I Siddiqui, R A Shubha, M Abu-Bakar, P K Chanda, F I Haque
Clinical significance of low free T₃ (FT₃) has not been well explained in patients with type 2 diabetes mellitus (T2DM); FT₃ level may be associated with diabetes control and also with diabetic complications. This cross-sectional study was carried out among 153 (mean age 46.8±12 years; female 68%, mean duration of diabetes 5.5±0.53 years, 63.4% either overweight or obese) non-pregnant adults with T2DM who had no acute illness and were unaware about their thyroid function status from July 2016 to December 2016...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29769482/aetiological-factors-of-female-genitourinary-fistula
#12
F Z Aalpona, M Kamrul-Hasan, F Islam, S Hossain, S Akter, K F Ananya
The purpose of this observational cross-sectional study was to evaluate the histories of women with urinary incontinence caused by genitourinary fistulae in Bangladesh. This is an exploratory analysis to investigate possible contributing factors to the development of urogenital fistulae. Sixty four (64) women who were treated for urogenital fistulae at the National Fistula Center, Dhaka Medical College Hospital, Dhaka, Bangladesh were interviewed from July 2013 to December 2013. Their average age was 35.91 years; majorities were illiterate; had early marriage and came from poor family...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29769112/association-between-%C3%AE-blocker-use-and-mortality-in-critically-ill-patients-a-nested-cohort-study
#13
Shmeylan A Al Harbi, Khalid A Al Sulaiman, Hani Tamim, Hasan M Al-Dorzi, Musharaf Sadat, Yaseen Arabi
BACKGROUND: β-blockers have several indications in critically ill patients and are commonly used. The aim of this study is to examine the relationship between the use of β-blockers in critically ill patients and mortality. METHODS: This was a nested cohort study in which all medical-surgical ICU patients (N = 523) enrolled in a randomized clinical trial of intensive insulin therapy (ISRCTN07413772) were grouped according to β-blocker use during ICU stay. To account for the indication of β-blockers, we constructed a propensity score using selected clinically-relevant and statistically-significant variables related to β-blocker exposure and outcome...
May 16, 2018: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29768977/primary-care-physicians-perceptions-of-practice-improvement-as-a-professional-responsibility-a-cross-sectional-study
#14
Christopher R Stephenson, Christopher M Wittich, Joel E Pacyna, Matthew K Wynia, Omar Hasan, Jon C Tilburt
Continuous quality improvement is a component of professionalism. Maintenance of Certification (MOC) is a mechanism in the USA for physicians to keep current with medical knowledge and contribute to practice improvement. Little is known about primary care physicians' perceptions of the practice improvement (Part IV) components of MOC. We aimed to determine primary care physicians' perceptions of their professional responsibility to participate in Part IV MOC. This was a cross-sectional study of primary care physicians using the American Medical Association Masterfile...
December 2018: Medical Education Online
https://www.readbyqxmd.com/read/29765397/lvis-jr-device-for-y-stent-assisted-coil-embolization-of-wide-neck-intracranial-aneurysms-a-multicenter-experience
#15
Edgar A Samaniego, Aldo A Mendez, Thanh N Nguyen, Vladimir Kalousek, Waldo R Guerrero, Sudeepta Dandapat, Guilherme Dabus, Italo Linfante, Ameer E Hassan, Alexander Drofa, Evgueni Kouznetsov, David Leedahl, David Hasan, Alberto Maud, Santiago Ortega-Gutierrez
Background and Purpose: Complex wide-neck intracranial aneurysms are challenging to treat. We report a multicenter experience using the LVIS Jr stent for "Y-stent"-assisted coiling embolization of wide-neck bifurcation aneurysms. Methods: Seven centers provided retrospective data on patients who underwent Y-stenting. Technical complications, immediate posttreatment angiographic results, clinical outcomes, and imaging follow-up were assessed. Results: Thirty patients/aneurysms were treated: 15 basilar tip, 8 middle cerebral artery, 4 anterior communicating artery, 1 pericallosal, and 2 posterior inferior cerebellar artery aneurysms...
April 2018: Interventional Neurology
https://www.readbyqxmd.com/read/29765069/de-novo-characterization-of-phenacoccus-solenopsis-transcriptome-and-analysis-of-gene-expression-profiling-during-development-and-hormone-biosynthesis
#16
Surjeet Kumar Arya, Yogeshwar Vikram Dhar, Santosh Kumar Upadhyay, Mehar Hasan Asif, Praveen Chandra Verma
The cotton mealybug Phenacoccus solenopsis is a devastating pest of cotton causing tremendous loss in the yield of crops each year. Widespread physiological and biological studies on P. solenopsis have been carried out, but the lack of genetic information has constrained our understanding of the molecular mechanisms behind its growth and development. To understand and characterize the different developmental stages, RNA-Seq platform was used to execute de-novo transcriptome assembly and differential gene expression profiling for the eggs, first, second, third instar and adult female stages...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29764378/grim-filter-fast-seed-location-filtering-in-dna-read-mapping-using-processing-in-memory-technologies
#17
Jeremie S Kim, Damla Senol Cali, Hongyi Xin, Donghyuk Lee, Saugata Ghose, Mohammed Alser, Hasan Hassan, Oguz Ergin, Can Alkan, Onur Mutlu
BACKGROUND: Seed location filtering is critical in DNA read mapping, a process where billions of DNA fragments (reads) sampled from a donor are mapped onto a reference genome to identify genomic variants of the donor. State-of-the-art read mappers 1) quickly generate possible mapping locations for seeds (i.e., smaller segments) within each read, 2) extract reference sequences at each of the mapping locations, and 3) check similarity between each read and its associated reference sequences with a computationally-expensive algorithm (i...
May 9, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29761849/muc1-c-drives-myeloid-leukaemogenesis-and-resistance-to-treatment-by-a-survivin-mediated-mechanism
#18
Dina Stroopinsky, Hasan Rajabi, Myrna Nahas, Jacalyn Rosenblatt, Maryam Rahimian, Athalia Pyzer, Ashujit Tagde, Akriti Kharbanda, Salvia Jain, Turner Kufe, Rebecca K Leaf, Eleni Anastasiadou, Michal Bar-Natan, Shira Orr, Maxwell D Coll, Kristen Palmer, Adam Ephraim, Leandra Cole, Abigail Washington, Donald Kufe, David Avigan
Acute myeloid leukaemia (AML) is an aggressive haematological malignancy with an unmet need for improved therapies. Responses to standard cytotoxic therapy in AML are often transient because of the emergence of chemotherapy-resistant disease. The MUC1-C oncoprotein governs critical pathways of tumorigenesis, including self-renewal and survival, and is aberrantly expressed in AML blasts and leukaemia stem cells (LSCs). However, a role for MUC1-C in linking leukaemogenesis and resistance to treatment has not been described...
May 15, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29761226/renal-stone-composition-does-not-affect-the-outcome-of-percutaneous-nephrolithotomy-in-children
#19
Onur Kaygısız, Fethi Ahmet Türegün, Nihat Satar, Ender Özen, Serdar Toksöz, Hasan Serkan Doğan, Mehmet Mesut Pişkin, Volkan İzol, Şaban Sarıkaya, Hakan Kılıçarslan, Tufan Çiçek, Ahmet Öztürk, Serdar Tekgül, Bülent Önal
PURPOSE: We sought to investigate the association between renal stone composition and percutaneous nephrolithotomy outcomes in pediatric patients and define the characterization of the stone composition. METHODS: The data of 1157 children who underwent percutaneous nephrolithotomy between 1991 and 2012 were retrieved from the multicenter database of the Turkish Pediatric Urology Society. The study population comprised 359 children (160 girls, 199 boys) with stone analyses...
May 14, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29759944/testing-assumptions-on-prefrontal-transcranial-direct-current-stimulation-comparison-of-electrode-montages-using-multimodal-fmri
#20
Jana Wörsching, Frank Padberg, Stephan Goerigk, Irmgard Heinz, Christine Bauer, Christian Plewnia, Alkomiet Hasan, Birgit Ertl-Wagner, Daniel Keeser
BACKGROUND: Transcranial direct current stimulation (tDCS) of the prefrontal cortex (PFC) has been widely applied in cognitive neurosciences and advocated as a therapeutic intervention, e.g. in major depressive disorder. Although several targets and protocols have been suggested, comparative studies of tDCS parameters, particularly electrode montages and their cortical targets, are still lacking. OBJECTIVE: This study investigated a priori hypotheses on specific effects of prefrontal-tDCS montages by using multimodal functional magnetic resonance imaging (fMRI) in healthy participants...
May 4, 2018: Brain Stimulation
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