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https://www.readbyqxmd.com/read/28102666/a-simulation-approach-for-timing-analysis-of-genetic-logic-circuits
#1
Hasan Baig, Jan Madsen
Constructing genetic logic circuits is an application of synthetic biology, where parts of the DNA of a living cell are engineered to perform a dedicated Boolean function triggered by appropriate concentration levels of certain proteins or by different genetic components. These logic circuits work in a manner similar to electronic logic circuits, but are much more stochastic and hence much harder to characterize. In this paper, we introduce an approach to analyze the threshold value and timing of genetic logic circuits...
January 19, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28101875/sustanon-induces-dose-independent-hypertrophy-and-satellite-cell-proliferation-in-slow-oxidative-fibers-of-avian-skeletal-muscle
#2
Mohammed Z Allouh, Ahmad A Jarrar, Hasan A Asfour, Raed S Said, Emad I Shaqoura
Sustanon is a well-known anabolic drug that is used to treat hypogonadism and restore muscle mass and bone density. As research to date has been limited to its effects in glycolytic fibers, this study aimed to investigate the dose-related effects of Sustanon on the oxidative fibers of avian skeletal muscle. Adult female chickens were randomly divided into 4 groups: control (C), received a dose of 100 μl normal saline per injection; and Sustanon-1, -2, and -3 (S1, S2, and S3), that received a dose of 12.5, 25, or 50 mg/kg Sustanon per injection, respectively...
January 19, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28100944/ostomy-in-nontraumatic-conditions-our-experience-and-review-of-the-literature
#3
Kenan Büyükaşık, Bünyamin Gürbulak, Emre Özoran, Yiğit Düzköylü, Esin Kabul Gürbulak, Aziz Arı, Hasan Bektaş
A number of nontraumatic acute abdomen can result in peritonitis leading to sepsis. In emergent conditions, various procedures like segmentary colectomy and/or subtotal colectomy with anastomosis, Hartmann's procedure, transverse colectomy, and/or expandable metallic stent (SEMS) placement can be performed, considering the status of the patient and the facilitaties of the institution. In our study, we examined the cases diagnosed as acute abdomen without the history of trauma, which had lead to a procedure requiring colostomy...
December 2016: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28100877/transcatheter-aortic-valve-implantation-with-different-valve-designs-for-severe-device-landing-zone-calcification
#4
Yoshio Maeno, Yigal Abramowitz, Yoshio Kazuno, Hiroyuki Kawamori, Geeteshwar Mangat, Nobuyuki Takahashi, Tarun Chakravarty, Mamoo Nakamura, Wen Cheng, Hasan Jilaihawi, Raj R Makkar
Severe device landing zone calcification (DLZ-CA) predicted paravalvular leak (PVL) and post-dilatation (PD) after transcatheter aortic valve implantation (TAVI). The aim of this study was to determine the influence of DLZ-CA on PVL or PD rates after SAPIEN XT (XT) versus CoreValve (CV).We analyzed patients undergoing TAVI who had severe DLZ-CA. Severe DLZ-CA defined the upper left ventricular outflow tract calcification; the cross-sectional region 2 mm inferior to the annular plane. PVL was evaluated at 30days using transthoracic echocardiography...
January 17, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28100300/molecular-analysis-and-species-diversity-of-nocardia-in-hospital-environment-of-a-developing-country-a-potential-health-hazard
#5
Hossein Ali Rahdar, Davood Azadi, Hasan Shojaei, Abbas Daei Naser
BACKGROUND: Despite hundreds of reports on the isolation of Nocardia from clinical samples, the presence and diversity of Nocardia species capable of survival in a harsh and adverse condition such as hospital environment have not been comprehensively studied. The aim of this study was to assess the Nocardia species diversity in the hospital environment to provide a better insight on their potential threat as a reservoir for the development of nosocomial infections. MATERIALS AND METHODS: A total of 90 hospital water, dust and soil samples collected from 30 hospitals were analyzed for the presence of Nocardia using standard protocols for isolation and characterization of the isolates...
January 17, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28099463/the-differential-effects-of-anesthetics-on-bacterial-behaviors
#6
Matthew Chamberlain, Sophia Koutsogiannaki, Matthew Schaefers, Hasan Babazada, Renyu Liu, Koichi Yuki
Volatile anesthetics have been in clinical use for a long period of time and are considered to be promiscuous by presumably interacting with several ion channels in the central nervous system to produce anesthesia. Because ion channels and their existing evolutionary analogues, ion transporters, are very important in various organisms, it is possible that volatile anesthetics may affect some bacteria. In this study, we hypothesized that volatile anesthetics could affect bacterial behaviors. We evaluated the impact of anesthetics on bacterial growth, motility (swimming and gliding) and biofilm formation of four common bacterial pathogens in vitro...
2017: PloS One
https://www.readbyqxmd.com/read/28098222/dose-dependency-and-reversibility-of-radiation-induced-injury-in-cardiac-explant-derived-cells-of-mice
#7
Lan Luo, Chen Yan, Yoshishige Urata, Al Shaimaa Hasan, Shinji Goto, Chang-Ying Guo, Shouhua Zhang, Tao-Sheng Li
We evaluated the dose-dependency and reversibility of radiation-induced injury in cardiac explant-derived cells (CDCs), a mixed cell population grown from heart tissues. Adult C57BL/6 mice were exposed to 0, 10, 50 and 250 mGy γ-rays for 7 days and atrial tissues were collected for experiments 24 hours after last exposure. The number of CDCs was significantly decreased by daily exposure to over 250 mGy. Interestingly, daily exposure to over 50 mGy significantly decreased the c-kit expression and telomerase activity, increased 53BP1 foci in the nuclei of CDCs...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28097644/erratum-to-eur-j-ophthalmol-2002-12-1-1-4-and-eur-j-ophthalmol-2015-25-5-437-442
#8
(no author information available yet)
Erratum To: Eur J Ophthalmol. 2002 Jan-Feb;12(1):1-4. doi: 10.5301/EJO.2008.799. Prevalence of astigmatism among students in northern Greece. A.T. Mandalos, D.K. Peios, T.A. Mavrakanas, V.A. Golias, K.G. Megalou, K.A. Delidou, A.C. Gregoriadou, B.C. Katsougiannopoulos PMID: 11936436 [PubMed - indexed for MEDLINE]We inform our readers that in the author list the full name of one author (T.A. Mavracanas) was published incorrectly. We supply the correct author listing and apologize to the readers. Eur J Ophthalmol...
December 29, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28097321/diagnostic-yield-and-novel-candidate-genes-by-exome-sequencing-in-152-consanguineous-families-with-neurodevelopmental-disorders
#9
Miriam S Reuter, Hasan Tawamie, Rebecca Buchert, Ola Hosny Gebril, Tawfiq Froukh, Christian Thiel, Steffen Uebe, Arif B Ekici, Mandy Krumbiegel, Christiane Zweier, Juliane Hoyer, Karolin Eberlein, Judith Bauer, Ute Scheller, Tim M Strom, Sabine Hoffjan, Ehab R Abdelraouf, Nagwa A Meguid, Ahmad Abboud, Mohammed Ayman Al Khateeb, Mahmoud Fakher, Saber Hamdan, Amina Ismael, Safia Muhammad, Ebtessam Abdallah, Heinrich Sticht, Dagmar Wieczorek, André Reis, Rami Abou Jamra
Importance: Autosomal recessive inherited neurodevelopmental disorders are highly heterogeneous, and many, possibly most, of the disease genes are still unknown. Objectives: To promote the identification of disease genes through confirmation of previously described genes and presentation of novel candidates and provide an overview of the diagnostic yield of exome sequencing in consanguineous families. Design, Setting, and Participants: Autozygosity mapping in families and exome sequencing of index patients were performed in 152 consanguineous families (the parents descended from a same ancestor) with at least 1 offspring with intellectual disability (ID)...
January 11, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28096926/congenital-anterior-urethral-diverticulum-presenting-as-a-scrotal-mass-in-a-two-year-old-child
#10
Ali Gürağaç, Hasan Cem Irkilata, Nahit Yunusov, Zafer Demirer
Here, we describe a case of congenital anterior urethral diverticulum (CAUD) in a two-year-old boy, who presented with right inguinoscrotal swelling that mimicked a spermatic cord cyst or hydrocele. Accurate diagnosis was made intraoperatively by retrograde urethrography. Open diverticulectomy and primary urethroplasty were performed for its management. The clinical presentation, diagnosis, and the management of this rare condition is discussed.
November 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28095701/malignant-bowel-obstruction-in-advanced-ovarian-cancer
#11
Emma Dean, Leila Khoja, Andrew Clamp, Gordon C Jayson, Dilly Goonetilleke, Alicia M Conway, Jurjees Hasan
AIM: Malignant bowel obstruction (MBO) in ovarian cancer is poorly understood. METHODS: This retrospective cohort study analyzed 129 patients with ovarian cancer and MBO. RESULTS: At presentation, 69 (53%) had platinum-resistant, 37 (29%) platinum-sensitive and 23 (18%) chemotherapy-naive disease. In patients receiving chemotherapy following the MBO episode, median overall survival (OS) was 107 days for chemotherapy-naive patients compared with 83 and 86 for platinum-sensitive or platinum-resistant patients (p = 0...
January 18, 2017: Future Oncology
https://www.readbyqxmd.com/read/28093057/if-it-works-for-pills-can-it-work-for-skills-direct-to-consumer-social-marketing-of-evidence-based-psychological-treatments
#12
Robert D Friedberg, Hasan Bayar
The emergence of evidence-based psychological treatments (EVPTs) is a scientific success story, but unfortunately the application of these empirically supported procedures has been slow to gain ground in treatment-as-usual settings. This Open Forum commentary argues that direct-to-consumer (DTC) marketing, which has worked well in communicating the advantages of various medicines, should perhaps be considered for use in social marketing of EVPTs. DTC marketing of pharmaceuticals is a long-standing advertising strategy in the United States...
January 17, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28092784/inflammatory-myofibroblastic-tumor-involving-liver-gallbladder-pylorus-duodenum-a-rare-case-presentation
#13
Lakshmi Sinha, Arshad Hasan, Akhilesh Kumar Singh, Poonam Prasad Bhadani, Achyuta Nand Jha, Prashant Kumar Singh, Manoj Kumar
Inflammatory myofibroblastic tumors are rare benign tumors that can mimic malignancy of unknown aetiology. It has spectrum of myofibroblastic proliferation along with varying amount of inflammatory infiltrate. Recently, the concept of this lesion being reactive has been challenged based on the clinical demonstration of recurrences and metastasis and cytogenetic evidence of acquired clonal chromosomal abnormalities. We hereby report a case of inflammatory myofibroblastic tumor involving liver, gallbladder pylorus and 1st part of duodenum...
January 5, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28090183/sleep-patterns-and-predictors-of-poor-sleep-quality-among-medical-students-in-king-khalid-university-saudi-arabia
#14
Aesha Farheen Siddiqui, Hasan Al-Musa, Hasan Al-Amri, Abdulkareem Al-Qahtani, Mushabab Al-Shahrani, Mohammad Al-Qahtani
BACKGROUND: Sleep problems and poor sleep quality are important issues for medical students. This study aimed to investigate the sleep patterns, measure the prevalence of poor sleep quality, and identify the predictors of poor sleep among medical students in King Khalid University (KKU), Saudi Arabia. METHODS: This cross-sectional study enrolled 318 medical students during October-November, 2015. Participants were selected by convenience sampling and data were collected using self-administered questionnaires to obtain information regarding socio-demographic variables and indicators of sleep quality...
November 2016: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/28090030/effect-of-polymerization-cycles-on-flexural-strengths-and-microhardness-of-different-denture-base-materials
#15
Hasan Gungor, Mustafa Gundogdu, Murat Alkurt, Zeynep Yesil Duymus
The purpose of this study was to evaluate the effect of different polymerization cycles on the flexural strengths and microhardness of two denture base materials (Meliodent and Paladent). Heat-polymerized acrylic resin specimens (65.0 mm long×10.0 mm wide×2.5 mm in height) were prepared using different short and long polymerization cycles. After the specimens had been polymerized, they were stored in distilled water at 37±1°C for 24 h. Flexural strength test was performed at a cross-head speed of 5 mm/min and Vickers microhardness was measured...
January 13, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/28089526/a-feasibility-study-of-2-mm-bolus-for-postmastectomy-radiation-therapy
#16
Lauren C Das, Daniel W Golden, Eugenia Perevalova, Anthony C Wong, Kimberly De Nardo, Christopher Stepaniak, Daniel S Joyce, Bradley P McCabe, Yasmin Hasan, Steven J Chmura, Anne McCall
PURPOSE: The purpose of this study was to prospectively evaluate the use of daily 2-mm bolus in patients undergoing postmastectomy radiation without reconstruction using optically stimulated luminescence dosimetry and weekly assessment of skin toxicity. METHODS AND MATERIALS: We prospectively collected data from the first 49 women treated with a daily 2-mm Superflab bolus during their postmastectomy radiation therapy from 2013 to 2016 at The University of Chicago Comprehensive Cancer Center at Silver Cross...
October 24, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28088331/eicosapentaenoic-acid-ameliorates-palmitate-induced-lipotoxicity-via-the-amp-kinase-dynamin-related-protein-1-signaling-pathway-in-differentiated-h9c2-myocytes
#17
Atsushi Sakamoto, Masao Saotome, Prottoy Hasan, Terumori Satoh, Hayato Ohtani, Tsuyoshi Urushida, Hideki Katoh, Hiroshi Satoh, Hideharu Hayashi
BACKGROUND: Emerging evidence suggested the preferable effects of eicosapentaenoic acid (EPA; n-3 polyunsaturated fatty acid) against cardiac lipotoxicity, which worsens cardiac function by means of excessive serum free fatty acids due to chronic adrenergic stimulation under heart failure. Nonetheless, the precise molecular mechanisms remain elusive. In this study, we focused on dynamin-related protein-1 (Drp1) as a possible modulator of the EPA-mediated cardiac protection against cardiac lipotoxicity, and investigated the causal relation between AMP-activated protein kinase (AMPK) and Drp1...
January 11, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28086849/successful-outcome-following-pneumonectomy-in-a-teenage-boy-with-cystic-fibrosis-a-case-report
#18
Zheyi Liew, Santosh Mallikarjuna, Asif Hasan, F Kate Gould, Su Bunn, Matthew F Thomas, Jim L Lordan, Christopher O'Brien, Malcolm Brodlie
BACKGROUND: Cystic fibrosis lung disease is generally a diffuse process however rarely one lung may become particularly damaged through chronic collapse and consolidation resulting in end-stage bronchiectasis with relative sparing of the contralateral lung. This clinical situation is sometimes referred to as "destroyed lung". Lung resection surgery is seldom indicated in cystic fibrosis and the associated medical literature is relatively sparse. CASE PRESENTATION: A 14 year old boy was referred to our centre for lung transplantation assessment...
January 13, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28081328/cytomegalovirus-hepatitis-in-49-pediatric-patients-with-normal-immunity
#19
Hasan Tezer, Saliha Kanık Yüksek, Belgin Gülhan, Aslı Nur Özkaya Parlakay, Ceyda Tuna Kırsaçlıoğlu
BACKGROUND/AIM: Cytomegalovirus (CMV) hepatitis is generally asymptomatic or rarely can lead to severe complications in immunocompetent hosts. This study aims to evaluate CMV hepatitis in immunocompetent young children, which is discussed relatively rarely in the literature. MATERIALS AND METHODS: A retrospective review of 49 pediatric patients with CMV hepatitis from January 2005 to December 2010 was performed. RESULTS: The median age of the patients was 5...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28081324/treatment-efficacy-and-superinfection-rates-in-complicated-urinarytract-infections-treated-with-ertapenem-or-piperacillin-tazobactam
#20
Murat Dizbay, Hasan Selçuk Özger, Ömer Karaşahin, Emine Fusun Karaşahin
BACKGROUND/AIM: In this retrospective study, the efficacy of ertapenem and piperacillin tazobactam was compared in the treatment of complicated urinary tract infections (cUTIs). Treatment responses were also evaluated for both antibiotics. MATERIALS AND METHODS: A total of 230 patients were enrolled in the study. Of these, 170 received ertapenem and 60 received piperacillin-tazobactam. RESULTS: In both groups, urine cultures after 48 h were negative for the initial uropathogen...
December 20, 2016: Turkish Journal of Medical Sciences
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