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asthma and pregnancy

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https://www.readbyqxmd.com/read/28286601/allergic-diseases-and-asthma-in-pregnancy-a-secondary-publication
#1
REVIEW
Isabella Pali-Schöll, Jennifer Namazy, Erika Jensen-Jarolim
Every fifth pregnant woman is affected by allergies, especially rhinitis and asthma. Allergic symptoms existing before pregnancy may be either attenuated, or equally often promoted through pregnancy. Optimal allergy and asthma diagnosis and management during pregnancy is vital to ensure the welfare of mother and baby. For allergy diagnosis in pregnancy, preferentially anamnestic investigation as well as in vitro testing should be applied, whereas skin testing or provocation tests should be postponed until after birth...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28285844/vitamin-d-supplementation-in-pregnancy-prenatal-25-oh-d-levels-race-and-subsequent-asthma-or-recurrent-wheeze-in-offspring-secondary-analyses-from-the-vitamin-d-antenatal-asthma-reduction-trial
#2
Helene M Wolsk, Benjamin J Harshfield, Nancy Laranjo, Vincent J Carey, George O'Connor, Megan Sandel, Robert C Strunk, Leonard B Bacharier, Robert S Zeiger, Michael Schatz, Bruce W Hollis, Scott T Weiss, Augusto A Litonjua
BACKGROUND: Nutrient trials differ from drug trials because participants have varying circulating levels at entry into the trial. OBJECTIVE: We sought to study the effect of a vitamin D intervention in pregnancy between subjects of different races and the association between 25-hydroxyvitamin D3 (25[OH]D) levels in pregnancy and the risk of asthma/recurrent wheeze in offspring. METHODS: The Vitamin D Antenatal Asthma Reduction Trial is a randomized trial of pregnant women at risk of having children with asthma randomized to 4400 international units/d vitamin D or placebo plus 400 international units/d vitamin D...
March 9, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28275108/maternal-high-fat-diet-in-mice-leads-to-innate-airway-hyperresponsiveness-in-the-adult-offspring
#3
Kelvin D MacDonald, Aurelia R Moran, Ashley J Scherman, Cindy T McEvoy, Astrid S Platteau
Maternal obesity prior to and during pregnancy has been associated with an increased incidence of childhood asthma. As diets rich in saturated fat are linked to obesity and inflammation, we created a murine model to investigate the effect of maternal high-fat diet (HFD) on adult offspring airway hyperreactivity (AHR), a cardinal feature of asthma. Balb/cByJ dams were fed a HFD (60% fat Calories) or normal-fat diet (NFD) (10% fat Calories) from 8 weeks prior to first breeding through their pregnancies. Pups were weaned to either a HFD or NFD (at 4 weeks of age)...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28273340/evaluation-of-the-associations-between-childhood-asthma-and-prenatal-and-perinatal-factors
#4
Maryam Kashanian, Seyyedeh Samaneh Mohtashami, Mohammad Hassan Bemanian, Seyyed Ali Javad Moosavi, Maziar Moradi Lakeh
OBJECTIVE: To identify prenatal and perinatal risk factors for childhood asthma. METHODS: A retrospective case-control study was undertaken among children aged 7-14 years in Tehran, Iran, between March 2009 and November 2014. Data for children with asthma (Iranian nationality, non-smoking parents, and middle-class socioeconomic status) were compared with those for an equal number of age- and sex-matched non-asthmatic children. Prenatal and perinatal risk factors were evaluated via complete data sheets of maternal pregnancy and delivery...
March 8, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28255932/developmental-defects-of-enamel-in-first-permanent-molars-associated-with-use-of-asthma-drugs-in-preschool-aged-children-a-retrospective-case-control-study
#5
A Mastora, G Vadiakas, A Agouropoulos, P Gartagani-Panagiotopoulou, V Gemou Engesaeth
AIM: To investigate the association between the occurrences of developmental defects of enamel (DDE), in first permanent molars, and bronchodilators and/or corticosteroid intake for asthma-like episodic treatment at preschool age, in 6-12 year old children. METHODS: Children of the case group (n = 70) were followed in the Paediatric Pulmonary Unit and the Unit of Allergology, Asthma and Inflammation at 'Aghia Sofia' Children's Hospital, Athens, Greece and had used asthma drugs during their first 4 years of life...
March 2, 2017: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28250923/prenatal-exposure-to-selenium-may-protect-against-wheezing-in-children-by-the-age-of-3
#6
Nour Baïz, Julie Chastang, Gladys Ibanez, Isabella Annesi-Maesano
INTRODUCTION: It has been suggested that human in utero exposure to heavy metals such as selenium can reduce the prevalence of childhood asthma and allergic diseases. However, data on this topic are scarce. The objective of the present study was to assess the putative associations between maternal selenium level during pregnancy and the risk of asthma, wheezing, allergic rhinitis, and atopic dermatitis in children from the EDEN birth cohort by the age of 1 and 3 years. METHODS: Plasma selenium concentrations were measured in maternal blood during mid-pregnancy (24-28 weeks of gestation) in 861 mothers...
March 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28244294/vitamin-d-and-urinary-incontinence-among-korean-women-a-propensity-score-matched-analysis-from-the-2008-2009-korean-national-health-and-nutrition-examination-survey
#7
Hyo Serk Lee, Jun Ho Lee
A recent study investigated the role of vitamin D in urinary incontinence (UI). However, very few data are available on this topic. Therefore, we evaluated these relationships using nationally representative data from Korea. We included 6,451 women over the age of 20 years who had participated in the Korea National Health and Nutrition Examination Survey IV. We conducted a propensity-matched study by identifying women with UI. Women without UI, matched for menopause, number of pregnancies, hypertension, diabetes, body mass index, age, stroke, asthma, and chronic obstructive pulmonary disease, were selected as a control group at a 2:1 ratio...
April 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28237129/prenatal-paracetamol-use-and-asthma-in-childhood-a-systematic-review-and-meta-analysis
#8
G Fan, B Wang, C Liu, D Li
OBJECTIVES: Some studies have suggested that prenatal paracetamol exposure might associate with the risk of child asthma. However, other studies have not confirmed this result. Therefore, we conducted a meta-analysis to investigate their relationship. METHODS: Two authors searched Pubmed and Embase databases up to June 2016. The strength of the association was calculated with the OR and respective 95% CIs. The random-effects model was chosen to calculate the pooled OR...
February 22, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28224678/microbiome-autoimmunity-allergy-and-helminth-infection-the-importance-of-the-pregnancy-period
#9
Xian Chen, Su Liu, Qiao Tan, Yehuda Shoenfeld, Yong Zeng
Pregnancy is a special physical period in reproductive age women, which has a beneficial influence on the course of certain autoimmune diseases. It has been recently suggested that the microbiome undergoes profound changes during pregnancy that are associated with host physiological and immunological adaptations. The maternal microbiome remodeling during pregnancy is an active response of the mother, possibly to alter immune system status and to facilitate metabolic and immunological adaptations, which are needed for a successful pregnancy...
February 21, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28219350/women-s-experiences-of-personalised-support-for-asthma-care-during-pregnancy-a-systematic-review-of-the-literature
#10
Graham R Williamson, Anita O'Connor, Elmslie-Jones Kayleigh
BACKGROUND: Asthma and pregnancy are both sources of anxiety for women. Although there has been a focus on physiological management of asthma and pregnancy, there has been little research on the impact that personalised support can have on asthma care during pregnancy. This systematic review and narrative synthesis of the literature set out to answer the question 'What are women's experiences of asthma care, its management and education, during pregnancy?' METHODS: This systematic review was carried out using accepted methodology from the York Centre for Reviews and Dissemination...
February 20, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28214921/vitamin-d-administration-during-pregnancy-as-prevention-for-pregnancy-neonatal-and-postnatal-complications
#11
REVIEW
Carol L Wagner, Bruce W Hollis, Kalliopi Kotsa, Hana Fakhoury, Spyridon N Karras
Pregnancy represents a time of rapid bodily change, which includes physical proportions, physiology and responsibility. At this context, maternal vitamin D stores have been the objective of extensive scientific research during the last decades, focusing on their potential effects on maternal an neonatal health. A growing body of observational studies indicated that maternal hypovitaminosis D (as defined by maternal 25-hydroxyvitamin D [25(OH)D] levels <20 ng/ml or <50 nmol/l) is a significant risk factor for adverse neonatal outcomes including asthma, multiple sclerosis and other neurological disorders...
February 18, 2017: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/28211345/regulatory-t-and-b-cells-in-asthmatic-women-variations-from-pregnancy-to-postpartum
#12
C Martins, J Lima, G Nunes, L M Borrego
BACKGROUND AND OBJECTIVE: Allergic asthma and rhinitis are common in pregnancy. The immune mechanisms underlying the effects of asthma on pregnancy and vice versa are not completely understood. The aim of this study was to investigate changes in regulatory T and B cells in asthmatic women from late pregnancy to postpartum. METHODS: Four groups of women were enrolled for this study: asthmatic (n=23) and healthy (n=43) third trimester-pregnant women and asthmatic (n=33) and healthy (n=35) nonpregnant women...
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28211106/a-pilot-randomised-controlled-trial-investigating-a-mediterranean-diet-intervention-in-pregnant-women-for-the-primary-prevention-of-allergic-diseases-in-infants
#13
D A Sewell, V S Hammersley, A Robertson, G Devereux, A Stoddart, C J Weir, A Worth, A Sheikh
BACKGROUND: Observational studies suggest a potentially protective role of the Mediterranean diet (MD) in allergic diseases, including asthma. Large scale randomised controlled trials (RCTs) are needed to test the hypothesised allergy-prevention benefits of a MD during pregnancy. The present two-arm pilot RCT in pregnant women at high-risk of having a child who would develop allergic disease investigated maternal recruitment, retention and acceptability of an MD dietary intervention in the UK...
February 16, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28196638/japanese-guidelines-for-adult-asthma-2017
#14
REVIEW
Masakazu Ichinose, Hisatoshi Sugiura, Hiroyuki Nagase, Masao Yamaguchi, Hiromasa Inoue, Hironori Sagara, Jun Tamaoki, Yuji Tohda, Mitsuru Munakata, Kohei Yamauchi, Ken Ohta
Adult bronchial asthma is characterized by chronic airway inflammation, and presents clinically with variable airway narrowing (wheezes and dyspnea) and cough. Long-standing asthma induces airway remodeling, leading to intractable asthma. The number of patients with asthma has increased; however, the number of patients who die of asthma has decreased (1.2 per 100,000 patients in 2015). The goal of asthma treatment is to enable patients with asthma to attain normal pulmonary function and lead a normal life, without any symptoms...
February 11, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28192144/maternal-house-dust-mite-exposure-during-pregnancy-enhances-severity-of-hdm-induced-asthma-in-murine-offspring
#15
Phoebe K Richgels, Amnah Yamani, Claire A Chougnet, Ian P Lewkowich
BACKGROUND: Atopic status of the mother and maternal exposure to environmental factors is associated with increased asthma risk. Moreover, animal models demonstrate that exposure to allergens in strongly sensitized mothers influences offspring asthma development, suggesting that in utero exposures can influence offspring asthma. However, it is unclear whether maternal exposure to common human allergens like house dust mite (HDM), in the absence of additional adjuvants, influences offspring asthma development...
February 9, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28188842/vitamin-d-supplementation-during-pregnancy-improvements-in-birth-outcomes-and-complications-through-direct-genomic-alteration
#16
REVIEW
Bruce W Hollis, Carol L Wagner
Pregnancy represents a time of rapid change, including dramatic shifts in vitamin D metabolism. Circulating concentrations of the active form of vitamin D-1,25(OH)2D skyrocket early in pregnancy to levels that would be toxic to a nonpregnant adult, signaling a decoupling of vitamin D from the classic endocrine calcium metabolic pathway, likely serving an immunomodulatory function in the mother and her developing fetus. In this review, we summarize the unique aspects of vitamin D metabolism and the data surrounding vitamin D requirements during this important period...
February 7, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28185095/in-utero-exposure-to-%C3%AE-2-adrenergic-receptor-agonist-and-attention-deficit-hyperactivity-disorder-in-children
#17
Hong Liang, Jianping Chen, Maohua Miao, Jakob Christensen, Søren Dalsgaard, Wei Yuan, Jiong Li
We aimed to examine the association between in utero exposure to β2AA and risk of attention-deficit/hyperactivity disorder (ADHD). We established a cohort of 672,265 children born from 1998 to 2008 in Denmark. Children were categorized as exposed if their mothers had redeemed a prescription of β2AA in pregnancy (from 30 days prior to conception until delivery). We identified children diagnosed with ADHD in the Danish National Hospital Register for the first time after his/her third birthday. Log-linear Poisson regression was used to estimate adjusted incidence rate ratio (aIRR) of ADHD...
February 9, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28183434/multigenerational-cohorts-in-patients-with-asthma-and-allergy
#18
S Hasan Arshad, Wilfried Karmaus, Hongmei Zhang, John W Holloway
Recent observations that disease risk can be transmitted across generations without the need for direct exposure of the child to the index environmental insult has sparked interest in transgenerational inheritance. Epigenetics describes processes that modify gene expression without a change in the nucleotide sequence. Epigenetic processes can be induced in response to environmental exposures, can influence disease risk, and might explain these multigenerational effects. In experimental models a number of epigenetic mechanisms have been identified that could mediate vertical transmission of epigenetic inheritance...
February 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28183433/mechanisms-of-the-development-of-allergy-medall-introducing-novel-concepts-in-allergy-phenotypes
#19
REVIEW
Josep M Anto, Jean Bousquet, Mubeccel Akdis, Charles Auffray, Thomas Keil, Isabelle Momas, Dirkje S Postma, Rudolf Valenta, Magnus Wickman, Anne Cambon-Thomsen, Tari Haahtela, Bart N Lambrecht, Karin C Lodrup Carlsen, Gerard H Koppelman, Jordi Sunyer, Torsten Zuberbier, Isabelle Annesi-Maesano, Albert Arno, Carsten Bindslev-Jensen, Giuseppe De Carlo, Francesco Forastiere, Joachim Heinrich, Marek L Kowalski, Dieter Maier, Erik Melén, Henriette A Smit, Marie Standl, John Wright, Anna Asarnoj, Marta Benet, Natalia Ballardini, Judith Garcia-Aymerich, Ulrike Gehring, Stefano Guerra, Cynthia Hohmann, Inger Kull, Christian Lupinek, Mariona Pinart, Ingebjorg Skrindo, Marit Westman, Delphine Smagghe, Cezmi Akdis, Niklas Andersson, Claus Bachert, Stephane Ballereau, Ferran Ballester, Xavier Basagana, Anna Bedbrook, Anna Bergstrom, Andrea von Berg, Bert Brunekreef, Emilie Burte, Kai-Hakon Carlsen, Leda Chatzi, Jonathan M Coquet, Mirela Curin, Pascal Demoly, Esben Eller, Maria Pia Fantini, Leena von Hertzen, Vergard Hovland, Benedicte Jacquemin, Jocelyne Just, Theresa Keller, Renata Kiss, Manolis Kogevinas, Sibylle Koletzko, Susanne Lau, Irina Lehmann, Nicolas Lemonnier, Mika Mäkelä, Jordi Mestres, Peter Mowinckel, Rachel Nadif, Martijn C Nawijn, Johan Pellet, Isabelle Pin, Daniela Porta, Fanny Rancière, Emmanuelle Rial-Sebbag, Yvan Saeys, Martijn J Schuijs, Valerie Siroux, Christina G Tischer, Mathies Torrent, Raphaelle Varraso, Kalus Wenzel, Cheng-Jian Xu
Asthma, rhinitis, and eczema are complex diseases with multiple genetic and environmental factors interlinked through IgE-associated and non-IgE-associated mechanisms. Mechanisms of the Development of ALLergy (MeDALL; EU FP7-CP-IP; project no: 261357; 2010-2015) studied the complex links of allergic diseases at the clinical and mechanistic levels by linking epidemiologic, clinical, and mechanistic research, including in vivo and in vitro models. MeDALL integrated 14 European birth cohorts, including 44,010 participants and 160 cohort follow-ups between pregnancy and age 20 years...
February 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28145207/pregnancy-heartburn-drugs-linked-to-childhood-asthma
#20
(no author information available yet)
Children whose mothers take medication to treat acid reflux during pregnancy have a greater risk of developing asthma, a new study claims.
February 1, 2017: Nursing Standard
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