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asthma and pregnancy

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https://www.readbyqxmd.com/read/28088397/antibiotics-in-pregnancy-increase-children-s-risk-of-otitis-media-and-ventilation-tubes
#1
Tine Marie Pedersen, Jakob Stokholm, Jonathan Thorsen, Anna-Rosa Cecilie Mora-Jensen, Hans Bisgaard
OBJECTIVES: To study the association between antibiotic intake in pregnancy and the development of otitis media and placement of ventilation tubes (VTs) in the offspring under the hypothesis that antibiotics in pregnancy may alter the offspring's propensity for disease. STUDY DESIGN: Data from the 700 children in the Copenhagen Prospective Studies on Asthma in Childhood 2010 unselected birth cohort study were used. Information on maternal antibiotic use and other exposures during pregnancy was collected prospectively from interviews and validated in national registries...
January 11, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28079560/prenatal-exposures-and-the-development-of-childhood-wheezing-illnesses
#2
Christian Rosas-Salazar, Tina V Hartert
PURPOSE OF REVIEW: To critically evaluate and summarize studies published between July 2015 and June 2016 linking prenatal exposures and the onset of childhood wheezing illnesses and to discuss future research directions in this field. RECENT FINDINGS: The aggregated evidence indicates a consistent detrimental effect of prenatal exposure to parental smoking, outdoor air pollution, and maternal stress on childhood wheezing illnesses. Less consistent evidence suggests an adverse impact of maternal obesity during pregnancy and prenatal exposure to antibiotics on these outcomes...
January 11, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28076614/association-between-asthma-and-female-sex-hormones
#3
Raquel Prudente de Carvalho Baldaçara, Ivaldo Silva
CONTEXT AND OBJECTIVE: The relationship between sex hormones and asthma has been evaluated in several studies. The aim of this review article was to investigate the association between asthma and female sex hormones, under different conditions (premenstrual asthma, use of oral contraceptives, menopause, hormone replacement therapy and pregnancy). DESIGN AND SETTING: Narrative review of the medical literature, Universidade Federal do Tocantins (UFT) and Universidade Federal de São Paulo (Unifesp)...
January 5, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28075198/impact-of-a-history-of-maternal-depression-and-anxiety-on-asthma-control-during-pregnancy
#4
Luke E Grzeskowiak, Brian Smith, Anil Roy, K Oliver Schubert, Bernhard T Baune, Gustaaf A Dekker, Vicki L Clifton
OBJECTIVE: To determine the impact of self-reported maternal depression/anxiety on asthma control during pregnancy. METHOD: Pregnant women with a doctor diagnosis of asthma (n = 189) were prospectively recruited at their antenatal booking visit and the presence of maternal depression and anxiety was identified using self-report and routine questionnaire assessments. Data on exacerbations and asthma control were collected during gestation. Asthma control was assessed using the Juniper asthma control questionnaire and women were classified as having recurrent uncontrolled asthma if their ACQ score was > 1...
January 11, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28039173/high-dose-fish-oil-supplements-in-late-pregnancy-reduce-asthma-in-offspring-finds-study
#5
Susan Mayor
No abstract text is available yet for this article.
December 30, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28029926/fish-oil-derived-fatty-acids-in-pregnancy-and-wheeze-and-asthma-in-offspring
#6
RANDOMIZED CONTROLLED TRIAL
Hans Bisgaard, Jakob Stokholm, Bo L Chawes, Nadja H Vissing, Elin Bjarnadóttir, Ann-Marie M Schoos, Helene M Wolsk, Tine M Pedersen, Rebecca K Vinding, Sunna Thorsteinsdóttir, Nilofar V Følsgaard, Nadia R Fink, Jonathan Thorsen, Anders G Pedersen, Johannes Waage, Morten A Rasmussen, Ken D Stark, Sjurdur F Olsen, Klaus Bønnelykke
Background Reduced intake of n-3 long-chain polyunsaturated fatty acids (LCPUFAs) may be a contributing factor to the increasing prevalence of wheezing disorders. We assessed the effect of supplementation with n-3 LCPUFAs in pregnant women on the risk of persistent wheeze and asthma in their offspring. Methods We randomly assigned 736 pregnant women at 24 weeks of gestation to receive 2.4 g of n-3 LCPUFA (fish oil) or placebo (olive oil) per day. Their children formed the Copenhagen Prospective Studies on Asthma in Childhood2010 (COPSAC2010) cohort and were followed prospectively with extensive clinical phenotyping...
29, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/28009318/indicators-of-phagocytic-component-and-secretory-iga-in-children-with-bronchial-asthma-secondary-to-undifferentiated-connective-tissue-dysplasia
#7
V Semianchuk, L Haridzhuk, O Bobrykovych
Its aim is to improve the diagnostics and treatment of Bronchial Asthma. There were examined 93 children with bronchial asthma at the age of 6-10 years. All patients were diagnosed with partially controlled or uncontrolled clinical course of bronchial asthma and manifestations of undifferentiated connective tissue dysplasia. The control group included 21 practically healthy children of the same age. The diagnosis of bronchial asthma was made, and the clinical course was determined in accordance with the criteria approved by the Order of Ministry of Health of Ukraine of October 08, 2013 No 868 "Unified clinical protocol of primary, secondary (specialized) medical care "Bronchial Asthma in Children" and GINA criteria (updated in 2015)...
November 2016: Georgian Medical News
https://www.readbyqxmd.com/read/28005253/diverging-conclusions-from-the-same-meta-analysis-in-drug-safety-source-of-data-primary-versus-secondary-takes-a-toll
#8
Guillermo Prada-Ramallal, Bahi Takkouche, Adolfo Figueiras
INTRODUCTION: Meta-analyses of observational studies represent an important tool for assessing efficacy and safety in the pharmacoepidemiologic field. The data from the individual studies are either primary (i.e., collected through interviews or self-administered questionnaires) or secondary (i.e., collected from databases that were established for other purposes). So far, the origin of the data (primary vs. secondary) has not been systematically assessed as a source of heterogeneity in pharmacoepidemiologic meta-analyses...
December 22, 2016: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/27993291/validation-of-asthma-control-questionnaire-and-risk-factors-affecting-uncontrolled-asthma-among-the-lebanese-children-s-population
#9
Souheil Hallit, Chantal Raherison, Mirna Waked, Pascale Salameh
OBJECTIVES: To validate the Arabic version of the Asthma Control Test (ACT) in asthmatic children in Lebanon and identify risk factors that might affect asthma control in these children. METHODS: This study, conducted between December 2015 and April 2016, included 300 children. RESULTS: A high Cronbach's alpha was found for the full scale (0.959). The correlation factors between each item of the ACT scale and the whole scale ranged between 0...
January 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/27981740/maternal-vitamin-d-status-during-pregnancy-and-risk-of-childhood-asthma%C3%A0-a-meta-analysis-of-prospective-studies
#10
Huihui Song, Lei Yang, Chongqi Jia
SCOPE: Mounting evidence suggests that maternal vitamin D status during pregnancy may be associated with development of childhood asthma, but the results are still inconsistent. A dose-response meta-analysis was performed to quantitatively summarize evidence on the association of maternal vitamin D status during pregnancy with the risk of childhood asthma. METHODS AND RESULTS: A systematic search was conducted to identify all studies assessing the association of maternal 25-hydroxyvitamin D (25(OH)D) during pregnancy with risk of childhood asthma...
December 16, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27966666/measurement-error-in-mobile-source-air-pollution-exposure-estimates-due-to-residential-mobility-during-pregnancy
#11
Audrey Flak Pennington, Matthew J Strickland, Mitchel Klein, Xinxin Zhai, Armistead G Russell, Craig Hansen, Lyndsey A Darrow
Prenatal air pollution exposure is frequently estimated using maternal residential location at the time of delivery as a proxy for residence during pregnancy. We describe residential mobility during pregnancy among 19,951 children from the Kaiser Air Pollution and Pediatric Asthma Study, quantify measurement error in spatially resolved estimates of prenatal exposure to mobile source fine particulate matter (PM2.5) due to ignoring this mobility, and simulate the impact of this error on estimates of epidemiologic associations...
December 14, 2016: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/27940979/disparities-in-the-context-of-opportunities-for-cancer-prevention-in-early-life
#12
Greta M Massetti, Cheryll C Thomas, Kathleen R Ragan
Persistent health disparities are a major contributor to disproportionate burden of cancer for some populations. Health disparities in cancer incidence and mortality may reflect differences in exposures to risk factors early in life. Understanding the distribution of exposures to early life risk and protective factors for cancer across different populations can shed light on opportunities to promote health equity at earlier developmental stages. Disparities may differentially influence risk for cancer during early life and create opportunities to promote health equity...
November 2016: Pediatrics
https://www.readbyqxmd.com/read/27931277/american-academy-of-allergy-asthma-immunology-membership-experience-with-allergen-immunotherapy-safety-in-patients-with-specific-medical-conditions
#13
Dsire E S Larenas-Linnemann, David W Hauswirth, Christopher W Calabria, Lawrence D Sher, Matthew A Rank
BACKGROUND: Little data in the literature exist concerning patients with certain underlying medical conditions who receive allergen subcutaneous immunotherapy (SCIT). OBJECTIVE: To survey allergists' experience with SCIT in patients with medical conditions considered to impose an elevated risk for untoward outcomes. METHODS: A Web-based survey was conducted among members of the American Academy of Allergy, Asthma Immunology to query about their experience with SCIT in patients with certain medical conditions...
September 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27927045/pharmacological-difficulties-in-the-treatment-of-asthma-in-pregnant-women
#14
Jennifer A Namazy, Michael Schatz
This is a review of the diagnosis and management of asthma in the pregnant patient. Asthma may adversely affect both maternal quality of life and, perinatal outcomes. Optimal management of asthma is thus important for both mother and baby. Areas covered: Special attention is paid to the challenges in diagnosis and management of asthma during pregnancy. Expert commentary: This article reviews the safety of asthma medications commonly used during pregnancy.
December 26, 2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/27917572/mannitol-challenge-testing-for-asthma-in-a-community-cohort-of-young-adults
#15
Elisha C White, Nicholas de Klerk, Zoltan Hantos, Monique Priston, Elysia M Hollams, Alan James, Peter D Sly, Patrick G Holt, Graham L Hall
BACKGROUND AND OBJECTIVE: Mannitol challenge testing is an established tool for clinical asthma diagnosis, and can be performed outside of specialized respiratory laboratories. Despite applicability in both clinical and non-clinical populations, with different pre-test asthma probabilities, differences in diagnostic properties have not been well explored. This study aimed to quantify the diagnostic utility of mannitol challenge testing for asthma in a community cohort and a symptomatic wheezing subset of this cohort...
December 5, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27913770/cor-triatriatum-a-review
#16
REVIEW
Ajay Kumar Jha, Neeti Makhija
Cor triatriatum is a rare congenital cardiac anomaly defined by an abnormal septation within the atrium (left or right) leading to inflow obstruction to the respective ventricles. It exists either in isolated classical form or may be associated with simple to complex congenital cardiac anomalies. Several anatomical variants exist even in the classical form, and therefore, it may require multimodal diagnostic modalities to characterize and differentiate for better percutaneous interventional or surgical planning...
December 2, 2016: Seminars in Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/27899314/preeclampsia-and-the-risk-of-cataract-extraction-in-life
#17
Nathalie Auger, Marc-André Rhéaume, Gilles Paradis, Jessica Healy-Profitós, Ada Hsieh, William D Fraser
BACKGROUND: Pregnancy-related risk factors for cataract are understudied, including the possibility that preeclampsia increases the risk of cataract later in life. OBJECTIVE: We sought to evaluate the long-term risk of cataract extraction following a preeclamptic pregnancy. STUDY DESIGN: We carried out a historic cohort study of 1,108,541 women who delivered at least 1 infant in any hospital in the province of Quebec, Canada, from 1989 through 2013, including 64,350 with preeclampsia and 5732 with cataract extractions...
November 27, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27888986/relationship-between-birth-weight-maternal-smoking-during-pregnancy-and-childhood-and-adolescent-lung-function-a-path-analysis
#18
Pallavi Balte, Wilfried Karmaus, Graham Roberts, Ramesh Kurukulaaratchy, Frances Mitchell, Hasan Arshad
BACKGROUND: Low birth weight and gestational maternal smoking have been linked with reduced lung function in children in many cross sectional studies. However, these associations have not yet been assessed with repeated measurements of lung function. Our aim was to investigate the effects of birth weight, gestational age, and gestational maternal smoking on lung function in children at age 10 and 18 years. METHODS: In the Isle of Wight birth cohort spirometry was performed at age 10 and 18 years...
December 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27878468/the-risk-of-adverse-pregnancy-outcome-after-first-trimester-exposure-to-h1-antihistamines-a-systematic-review-and-meta-analysis
#19
REVIEW
Fatma Etwel, Lauren H Faught, Michael J Rieder, Gideon Koren
INTRODUCTION: H1 antihistamines are used for the treatment of nausea and vomiting during pregnancy as well as the symptomatic relief of asthma, urticaria, allergy, and the common cold. Although they are overall felt to be safe during pregnancy, recently several studies have challenged this assumption, as millions of women are exposed to them in the first trimester. METHODS: Following the guidelines of PRISMA, a systematic review was performed to retrieve all published articles involving H1-antihistamine exposure during pregnancy...
November 22, 2016: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/27866770/tetanus-vaccination-is-associated-with-differential-dna-methylation-reduces-the-risk-of-asthma-in-adolescence
#20
Vimala Devi Janjanam, Nandini Mukherjee, Gabrielle A Lockett, Faisal I Rezwan, Ramesh Kurukulaaratchy, Frances Mitchell, Hongmei Zhang, Hasan Arshad, John W Holloway, Wilfried Karmaus
BACKGROUND: Vaccinations have been suggested to be associated with increased risk of allergic diseases. Tetanus vaccination is one of the most frequently administered vaccines as a part of wound management and was also found to be associated with increased serum IgE levels. We hypothesized that the vaccination modifies the risk of allergic diseases through epigenetic changes such as DNA methylation. METHOD: Data on tetanus vaccination between 10 and 18years of age was collected from a birth cohort established on the Isle of Wight UK in 1989...
December 12, 2016: Vaccine
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