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PD-1 CTLA4 LAG3

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https://www.readbyqxmd.com/read/23188506/durable-adoptive-immunotherapy-for-leukemia-produced-by-manipulation-of-multiple-regulatory-pathways-of-cd8-t-cell-tolerance
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Melissa M Berrien-Elliott, Stephanie R Jackson, Jennifer M Meyer, Craig J Rouskey, Thanh-Long M Nguyen, Hideo Yagita, Philip D Greenberg, Richard J DiPaolo, Ryan M Teague
Tolerizing mechanisms within the host and tumor microenvironment inhibit T-cell effector functions that can control cancer. These mechanisms blunt adoptive immunotherapy with infused T-cells due to a complex array of signals that determine T-cell tolerance, survival, or deletion. Ligation of the negative regulatory receptors CTLA4, PD-1(PDCD1), or LAG3 on T-cells normally hinders their response to antigen through nonredundant biochemical processes that interfere with stimulatory pathways. In this study, we used an established mouse model of T-cell tolerance to define the roles of these inhibitory receptors in regulating CD8(+) T-cell tolerance during adoptive immunotherapy to treat leukemia...
January 15, 2013: Cancer Research
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