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https://www.readbyqxmd.com/read/27921306/applying-a-family-resilience-framework-in-training-practice-and-research-mastering-the-art-of-the-possible
#1
Froma Walsh
With growing interest in systemic views of human resilience, this article updates and clarifies our understanding of the concept of resilience as involving multilevel dynamic processes over time. Family resilience refers to the functioning of the family system in dealing with adversity: Assessment and intervention focus on the family impact of stressful life challenges and the family processes that foster positive adaptation for the family unit and all members. The application of a family resilience framework is discussed and illustrated in clinical and community-based training and practice...
December 2016: Family Process
https://www.readbyqxmd.com/read/27920770/the-use-of-transposon-insertion-sequencing-to-interrogate-the-core-functional-genome-of-the-legume-symbiont-rhizobium-leguminosarum
#2
Benjamin J Perry, Mir S Akter, Christopher K Yost
The free-living legume symbiont Rhizobium leguminosarum is of significant economic value because of its ability to provide fixed nitrogen to globally important leguminous food crops, such as peas and lentils. Discovery based research into the genetics and physiology of R. leguminosarum provides the foundational knowledge necessary for understanding the bacterium's complex lifestyle, necessary for augmenting its use in an agricultural setting. Transposon insertion sequencing (INSeq) facilitates high-throughput forward genetic screening at a genomic scale to identify individual genes required for growth in a specific environment...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27920731/do-you-read-how-i-read-systematic-individual-differences-in-semantic-reliance-amongst-normal-readers
#3
Anna M Woollams, Matthew A Lambon Ralph, Gaston Madrid, Karalyn E Patterson
The extent to which meaning is involved in reading aloud has proven an area of longstanding debate, and current computational models differ on this dimension. The connectionist triangle model proposes that normal individuals rely on semantic information for correct reading of words with atypical spelling-sound relationships, but to varying degrees. This proposed individual difference would account for the varying stage of decline at which patients with semantic dementia first show the reading impairment known as surface dyslexia...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27920431/cerebral-blood-flow-blood-supply-and-cognition-in-type-2-diabetes-mellitus
#4
Jacobus F A Jansen, Frank C G van Bussel, Harm J van de Haar, Matthias J P van Osch, Paul A M Hofman, Martin P J van Boxtel, Robert J van Oostenbrugge, Miranda T Schram, Coen D A Stehouwer, Joachim E Wildberger, Walter H Backes
We investigated whether type 2 diabetes (T2DM) and the presence of cognitive impairment are associated with altered cerebral blood flow (CBF). Forty-one participants with and thirty-nine without T2DM underwent 3-Tesla MRI, including a quantitative technique measuring (macrovascular) blood flow in the internal carotid artery and an arterial spin labeling technique measuring (microvascular) perfusion in the grey matter (GM). Three analysis methods were used to quantify the CBF: a region of interest analysis, a voxel-based statistical parametric mapping technique, and a 'distributed deviating voxels' method...
December 2016: Scientific Reports
https://www.readbyqxmd.com/read/27920339/identification-of-chlorophyll-dephytylase-involved-in-chlorophyll-turnover-in-arabidopsis
#5
Yao-Pin Lin, Meng-Chen Wu, Yee-Yung Charng
Chlorophyll turns over in green organs during photosystem repair and is salvaged via de- and re-phytylation, but the enzyme involved in de-phytylation is unknown. We have identified an Arabidopsis thaliana thylakoid protein with a putative hydrolase domain that can dephytylate chlorophyll in vitro and in vivo. The corresponding locus, CHLOROPHYLL DEPHYTYLASE1 (CLD1), was identified by mapping a semi-dominant, heat-sensitive, missense allele (cld1-1). CLD1 is conserved in oxygenic photosynthetic organisms, sharing structural similarity with pheophytinase, which functions in chlorophyll breakdown during leaf senescence...
December 5, 2016: Plant Cell
https://www.readbyqxmd.com/read/27920095/functional-characterization-of-the-left-ventrolateral-premotor-cortex-in-humans-a-direct-electrophysiological-approach
#6
L Fornia, V Ferpozzi, M Montagna, M Rossi, M Riva, F Pessina, F Martinelli Boneschi, P Borroni, R N Lemon, L Bello, G Cerri
In monkeys, motor outputs from premotor cortex (PM) involve cortico-cortical connections with primary motor cortex (M1). However, in humans, the functional organization of PM and its relationship with the corticospinal tract (CST) is still uncertain. This study was carried out in 21 patients undergoing intraoperative brain mapping prior to tumor resection. The left ventrolateral premotor cortex (vlPM-BA6) was identified preoperatively by functional magnetic resonance imaging, and then investigated intraoperatively using high frequency direct electrical stimulation (HF-DES) of the convexity of M1 and vlPM-BA6, with simultaneous recording of motor-evoked potentials (MEPs) from oro-facial, hand and arm muscles...
December 5, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27919750/mapping-the-functional-connectome-in-traumatic-brain-injury-what-can-graph-metrics-tell-us
#7
Karen Caeyenberghs, Helena Verhelst, Adam Clemente, Peter H Wilson
OBJECTIVE: Traumatic brain injury (TBI) is associated with cognitive and motor deficits, and poses a significant personal, societal, and economic burden. One mechanism by which TBI is thought to affect cognition and behaviour is through changes in functional connectivity. Graph theory is a powerful framework for quantifying topological features of neuroimaging-derived functional networks. The objective of this paper is to review studies examining functional connectivity in TBI with an emphasis on graph theoretical analysis that is proving to be valuable in uncovering network abnormalities in this condition...
December 2, 2016: NeuroImage
https://www.readbyqxmd.com/read/27919584/assessment-of-population-exposure-to-pm2-5-for-mortality-in-china-and-its-public-health-benefit-based-on-benmap
#8
Li Chen, Mengshuang Shi, Shuang Gao, Suhuan Li, Jian Mao, Hui Zhang, Yanling Sun, Zhipeng Bai, Zhongliang Wang
Along with the rapid socioeconomic development, air pollution in China has become a severe problem. One component of air pollution, in particular, PM2.5 has aroused wide public concern because of its high concentration. In this study, data were collected from over 900 monitoring sites of the newly constructed PM2.5 monitoring network in China. The interpolation methods were used to simulate the PM2.5 exposure level of China especially in rural areas, thus reflecting the spatial variation of PM2.5 pollution...
December 2, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27919569/the-relation-between-radon-in-schools-and-in-dwellings-a-case-study-in-a-rural-region-of-southern-serbia
#9
Z S Žunić, P Bossew, F Bochicchio, N Veselinovic, C Carpentieri, G Venoso, S Antignani, R Simovic, Z Ćurguz, V Udovicic, Z Stojanovska, T Tollefsen
Recognized as a significant health hazard, radon (Rn) has been given increasing attention for years. Surveys of different kinds have been performed in many countries to assess the intensity and the geographical extent of possible Rn problems. Common surveys cover mainly dwellings, the indoor place with highest occupancy, and schools, where people spend a large fraction of their lifetime and which can also be considered exemplary for Rn exposure at workplaces; it has however been observed that relating them is difficult...
December 2, 2016: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/27919546/brain-morphometry-predicts-individual-creative-potential-and-the-ability-to-combine-remote-ideas
#10
David Bendetowicz, Marika Urbanski, Clarisse Aichelburg, Richard Levy, Emmanuelle Volle
For complex mental functions such as creative thinking, inter-individual variability is useful to better understand the underlying cognitive components and brain anatomy. Associative theories propose that creative individuals have flexible semantic associations, which allows remote elements to be formed into new combinations. However, the structural brain variability associated with the ability to combine remote associates has not been explored. To address this question, we performed a voxel-based morphometry (VBM) study and explored the anatomical connectivity of significant regions...
November 15, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27919398/what-is-needed-to-implement-a-web-based-audit-and-feedback-intervention-with-outreach-visits-to-improve-care-quality-a-concept-mapping-study-among-cardiac-rehabilitation-teams
#11
Mariëtte M van Engen-Verheul, Niels Peek, Joke A Haafkens, Erik Joukes, Tom Vromen, Monique W M Jaspers, Nicolette F de Keizer
INTRODUCTION: Evidence on successful quality improvement (QI) in health care requires quantitative information from randomized clinical trials (RCTs) on the effectiveness of QI interventions, but also qualitative information from professionals to understand factors influencing QI implementation. OBJECTIVE: Using a structured qualitative approach, concept mapping, this study determines factors identified by cardiac rehabilitation (CR) teams on what is needed to successfully implement a web-based audit and feedback (A&F) intervention with outreach visits to improve the quality of CR care...
January 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27919260/a-frameshift-mutation-in-mocos-is-associated-with-familial-renal-syndrome-xanthinuria-in-tyrolean-grey-cattle
#12
Leonardo Murgiano, Vidhya Jagannathan, Christian Piffer, Inmaculada Diez-Prieto, Marilena Bolcato, Arcangelo Gentile, Cord Drögemüller
BACKGROUND: Renal syndromes are occasionally reported in domestic animals. Two identical twin Tyrolean Grey calves exhibited weight loss, skeletal abnormalities and delayed development associated with kidney abnormalities and formation of uroliths. These signs resembled inherited renal tubular dysplasia found in Japanese Black cattle which is associated with mutations in the claudin 16 gene. Despite demonstrating striking phenotypic similarities, no obvious presence of pathogenic variants of this candidate gene were found...
December 5, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27919246/adjacent-sequences-disclose-potential-for-intra-genomic-dispersal-of-satellite-dna-repeats-and-suggest-a-complex-network-with-transposable-elements
#13
Eva Satović, Tanja Vojvoda Zeljko, Andrea Luchetti, Barbara Mantovani, Miroslav Plohl
BACKGROUND: Satellite DNA (satDNA) sequences are typically arranged as arrays of tandemly repeated monomers. Due to the similarity among monomers, their organizational pattern and abundance, satDNAs are hardly accessible to structural and functional studies and still represent the most obscure genome component. Although many satDNA arrays of diverse length and even single monomers exist in the genome, surprisingly little is known about transition from satDNAs to other sequences. Studying satDNA monomers at junctions and identifying DNA sequences adjacent to them can help to understand the processes that (re)distribute satDNAs and significance that evolution of these sequence elements might have in creating the genomic landscape...
December 6, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27918346/electrical-stimulation-for-seizure-induction-and-functional-mapping-in-stereoelectroencephalography
#14
Agnès Trébuchon, Patrick Chauvel
The challenge in epilepsy surgery is to remove the epileptogenic zone without compromising postoperative function. Electrical stimulation (ES) was developed to identify with greater anatomical and physiological precision cortical structures essential to language and motor function. Because the language network is widely distributed in the left (dominant) hemisphere, and often varies among patients, brain mapping should delineate eloquent areas at the individual level. Although ES for language is commonly performed during a presurgical investigation, the procedure remains nonstandardized among centers, and differences between grids and intracerebral depth electrodes (stereoelectroencephalography) should be taken into account when comparing results from different series...
December 2016: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/27917894/a-closer-look-into-the-%C3%AE-helix-basin
#15
Boris Haimov, Simcha Srebnik
α-Helices are the most abundant structures found within proteins and play an important role in the determination of the global structure of proteins and their function. Representation of α-helical structures with the common (φ, ψ) dihedrals, as in Ramachandran maps, does not provide informative details regarding the helical structure apart for the abstract geometric meaning of the dihedrals. We present an alternative coordinate system that describes helical conformations in terms of residues per turn (ρ) and angle (ϑ) between backbone carbonyls relative to the helix direction through an approximate linear transformation between the two coordinates system (φ, ψ and ρ, ϑ)...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27917569/distinct-intrinsic-functional-brain-network-abnormalities-in-methamphetamine-dependent-patients-with-and-without-a-history-of-psychosis
#16
Jonathan C Ipser, Anne Uhlmann, Paul Taylor, Brian H Harvey, Don Wilson, Dan J Stein
Chronic methamphetamine use is associated with executive functioning deficits that suggest dysfunctional cognitive control networks (CCNs) in the brain. Likewise, abnormal connectivity between intrinsic CCNs and default mode networks (DMNs) has also been associated with poor cognitive function in clinical populations. Accordingly, we tested the extent to which methamphetamine use predicts abnormal connectivity between these networks, and whether, as predicted, these abnormalities are compounded in patients with a history of methamphetamine-associated psychosis (MAP)...
December 5, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27917312/a-4d-ct-digital-phantom-of-an-individual-human-brain-for-perfusion-analysis
#17
Rashindra Manniesing, Christoph Brune, Bram van Ginneken, Mathias Prokop
Brain perfusion is of key importance to assess brain function. Modern CT scanners can acquire perfusion maps of the cerebral parenchyma in vivo at submillimeter resolution. These perfusion maps give insights into the hemodynamics of the cerebral parenchyma and are critical for example for treatment decisions in acute stroke. However, the relations between acquisition parameters, tissue attenuation curves, and perfusion values are still poorly understood and cannot be unraveled by studies involving humans because of ethical concerns...
2016: PeerJ
https://www.readbyqxmd.com/read/27916830/influence-of-fragrances-on-human-psychophysiological-activity-with-special-reference-to-human-electroencephalographic-response
#18
REVIEW
Kandhasamy Sowndhararajan, Songmun Kim
The influence of fragrances such as perfumes and room fresheners on the psychophysiological activities of humans has been known for a long time, and its significance is gradually increasing in the medicinal and cosmetic industries. A fragrance consists of volatile chemicals with a molecular weight of less than 300 Da that humans perceive through the olfactory system. In humans, about 300 active olfactory receptor genes are devoted to detecting thousands of different fragrance molecules through a large family of olfactory receptors of a diverse protein sequence...
November 29, 2016: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/27916710/aberrant-regional-homogeneity-in-parkinson-s-disease-a-voxel-wise-meta-analysis-of-resting-state-functional-magnetic-resonance-imaging-studies
#19
REVIEW
PingLei Pan, Hui Zhan, MingXu Xia, Yang Zhang, DeNing Guan, Yun Xu
Studies of abnormal regional homogeneity (ReHo) in Parkinson's disease (PD) have reported inconsistent results. Therefore, we conducted a meta-analysis using the Seed-based d Mapping software package to identify the most consistent and replicable findings. A systematic literature search was performed to identify eligible whole-brain resting-state functional magnetic resonance imaging studies that had measured differences in ReHo between patients with PD and healthy controls between January 2000 and June 4, 2016...
December 1, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27916677/differential-copper-binding-to-alpha-synuclein-and-its-disease-associated-mutants-affect-the-aggregation-and-amyloid-formation
#20
Priyatosh Ranjan, Dhiman Ghosh, Deepthi S Yarramala, Subhadeep Das, Samir K Maji, Ashutosh Kumar
BACKGROUND: Copper is an essential trace element required for the proper functioning of various enzymes present in central nervous system. An imbalance in the copper homeostasis results in the pathology of various neurogenerative disorders including Parkinson's Disease. Hence, residue specific interaction of Cu(2+) to α-Syn along with the familial mutants H50Q and G51D needs to be studied in detail. METHODS: We investigated the residue specific mapping of Cu(2+) binding sites and binding strength using solution-state NMR and ITC respectively...
December 1, 2016: Biochimica et Biophysica Acta
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