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Periprosthetic osteolysis

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https://www.readbyqxmd.com/read/29892292/disease-associated-particulates-and-joint-inflammation-mechanistic-insights-and-potential-therapeutic-targets
#1
REVIEW
Olwyn R Mahon, Aisling Dunne
It is now well established that intra-articular deposition of endogenous particulates, such as osteoarthritis-associated basic calcium phosphate crystals, gout-associated monosodium urate crystals, and calcium deposition disease-associated calcium pyrophosphate crystals, contributes to joint destruction through the production of cartilage-degrading enzymes and pro-inflammatory cytokines. Furthermore, exogenous wear-debris particles, generated from prosthetic implants, drive periprosthetic osteolysis which impacts on the longevity of total joint replacements...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29869689/periprosthetic-acetabular-radiolucency-progression-in-mid-term-follow-up-of-the-articular-surface-replacement-hip-system
#2
Sean J Matuszak, Vincent P Galea, James W Connelly, Janus Christiansen, Orhun Muratoglu, Henrik Malchau
INTRODUCTION: Recent registry studies show that aseptic loosening secondary to osteolysis is the second leading cause of hip implant failure in patients implanted with metal-on-metal (MoM) bearings. The primary aim of our study was to report on the progression of acetabular osteolysis during mid-term follow-up in patients treated with MoM hip resurfacing arthroplasty (HRA) and MoM total hip arthroplasty (THA). The secondary aim was to identify independent predictors of osteolytic lesion progression...
June 5, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29862212/outcomes-of-unilateral-total-hip-arthroplasty-in-patients-aged-under-35-years-in-iranian-population-a-preliminary-study
#3
Mahdi Motififard, Ali Andalib, Seyed Jalil Hamidi, Sajad Badiei
Background: The purpose of this study is to report outcomes of total hip arthroplasty (THA) in patients under the age of 35 years regarding pain and joint function. Materials and Methods: This preliminary analytic-descriptive study was performed in prospective consecutive series of forty-three patients younger than 35 years old who had undergone unilateral THA during a 36-month period. As the primary outcome, the severity of pain using visual analog scale (VAS) of 1-10, and as the secondary outcomes, joint range of motion (ROM) and the Harris Hip Score (HHS) were assessed in the preoperative visit, 1, 6, and 18 months after operation for each patient...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29848366/effect-of-bisphosphonates-on-periprosthetic-bone-loss-after-total-knee-arthroplasty-a-meta-analysis-of-randomized-controlled-trials
#4
Mingmin Shi, Lei Chen, Haobo Wu, Yangxin Wang, Wei Wang, Yujie Zhang, Shigui Yan
BACKGROUND: Aseptic loosening and osteolysis are the most common indications after TKA for revision surgery. This meta-analysis which included high-quality randomized controlled trials (RCTs) aimed to analyze the effect of bisphosphonates (BPs) on maintaining periprosthetic bone mineral density (BMD) after total knee arthroplasty. METHODS: PubMed, AMED, EMBASE, the Cochrane library, ISI Web of Science, and China National Knowledge Infrastructure were systematically searched, five RCTs were included and the total number of participants was 188...
May 30, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29786751/inhibition-of-osteoclastogenesis-for-periprosthetic-osteolysis-therapy-through-the-suppression-of-p38-signaling-by-fraxetin
#5
Jia-Cheng Liao, Zhao-Xia Wei, Chang Zhao, Zhong-Ping Ma, Dao-Zhang Cai
Periprosthetic osteolysis belongs to osteolytic diseases, which often occur due to an imbalance between osteoclast and osteoblast number or activity. Fraxetin, a natural plant extract, inhibits osteoblast apoptosis and has therapeutic potential for treating osteolytic diseases. However, data pertaining to the effects of fraxetin on osteoclasts are limited. In the present study, it was demonstrated that the inhibition of osteoclastogenesis by fraxetin had an important role on the therapy of titanium particle‑induced osteolysis in vivo...
May 21, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29709064/effects-of-moderate-intensity-static-magnetic-fields-on-osteoclastic-differentiation-in-mouse-bone-marrow-cells
#6
Eun-Cheol Kim, Jaesuh Park, Gunwoo Noh, Su-Jung Park, Kwantae Noh, Il-Keun Kwon, Su-Jin Ahn
Although we recently demonstrated that static magnetic fields (SMFs) of 3, 15, and 50 mT stimulate osteoblastic differentiation, the effects of SMFs on osteoclastogenesis are still poorly understood. This study focused on the suppressive effects of SMFs on receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclastogenesis and bone resorption. Direct SMFs inhibit RANKL-induced multinucleated osteoclast formation, tartrate-resistant acid phosphatase activity, and bone resorption in mouse bone marrow-derived macrophage cells...
April 30, 2018: Bioelectromagnetics
https://www.readbyqxmd.com/read/29659776/disseminated-infection-of-encephalitozoon-cuniculi-associated-with-osteolysis-of-hip-periprosthetic-tissue-association-versus-causation
#7
Trisha Peel
No abstract text is available yet for this article.
April 5, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29659738/disseminated-infection-of-encephalitozoon-cuniculi-associated-with-osteolysis-of-hip-periprosthetic-tissue
#8
Marta Kicia, Maria Wesolowska, Zaneta Kopacz, Martin Kvác, Bohumil Sak, Magdalena Sokulska, Kamil Cebulski, Andrzej B Hendrich, Andrzej Pozowski
Background: Among patients with hip joint endoprosthesis, periprosthetic osteolysis is the most common complication following primary arthroplasty, and subsequent implant loosening is the leading cause of arthroplasty revision. Causes of stability loss, though not always evident, can be mechanical, allergic, or infectious (bacterial and fungal agents) in nature. Microsporidia, widespread opportunistic fungal pathogens that infect most human tissues, are a potential infectious cause of stability loss...
April 5, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29657845/long-term-bone-remodelling-around-legendary-cementless-femoral-stems
#9
Charles Rivière, Guido Grappiolo, Charles A Engh, Jean-Pierre Vidalain, Antonia-F Chen, Nicolas Boehler, Jihad Matta, Pascal-André Vendittoli
Bone remodelling around a stem is an unavoidable long-term physiological process highly related to implant design. For some predisposed patients, it can lead to periprosthetic bone loss secondary to severe stress-shielding, which is thought to be detrimental by contributing to late loosening, late periprosthetic fracture, and thus rendering revision surgery more complicated.However, these concerns remain theoretical, since late loosening has yet to be documented among bone ingrowth cementless stems demonstrating periprosthetic bone loss associated with stress-shielding...
February 2018: EFORT Open Reviews
https://www.readbyqxmd.com/read/29657840/third-generation-pure-alumina-and-alumina-matrix-composites-in-total-hip-arthroplasty-what-is-the-evidence
#10
Didier Hannouche, Matthieu Zingg, Hermes Miozzari, Remy Nizard, Anne Lübbeke
Wear, corrosion and periprosthetic osteolysis are important causes of failure in joint arthroplasty, especially in young patients.Ceramic bearings, developed 40 years ago, are an increasingly popular choice in hip arthroplasty. New manufacturing procedures have increased the strength and reliability of ceramic materials and reduced the risk of complications.In recent decades, ceramics made of pure alumina have continuously improved, resulting in a surgical-grade material that fulfills clinical requirements...
January 2018: EFORT Open Reviews
https://www.readbyqxmd.com/read/29656971/long-term-outcomes-after-metal-on-metal-total-hip-arthroplasty-with-a-28-mm-head-a-17-to-23-year-follow-up-study-of-a-previous-report
#11
Jun-Ki Moon, Yeesuk Kim, Kyu-Tae Hwang, Jae-Hyuk Yang, Young-Ha Oh, Young-Ho Kim
BACKGROUND: Second-generation, metal-on-metal total hip arthroplasty (MoM THA) using a 28-mm head has shown favorable results compared with large head MoM THA. The purpose of this study is to evaluate the long-term outcomes of cementless primary MoM THA with a 28-mm head and the incidence of osteolysis using computed tomography. METHODS: A total of 92 patients (53 men and 39 women) who underwent primary cementless MoM THA (114 hips) with a 28-mm head were enrolled in this study...
March 12, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29656074/protein-phosphatase-2a-as-a-new-target-for-downregulating-osteoclastogenesis-and-alleviating-titanium-particle-induced-bone-resorption
#12
Liangliang Wang, Xiaobin Guo, Wei Zhou, Yayun Ding, Jiawei Shi, Xiexing Wu, Yu Liu, Yaozeng Xu, Huilin Yang, Dechun Geng
Receptor activator of nuclear factor-кB ligand (RANKL)-induced osteoclastogenesis is believed to play a critical role in osteolytic diseases including peri-prosthetic osteolysis (PPO), the primary reason for implant failure and revision surgery. In this study, we observed that protein phosphatase 2A (PP2A), a major serine-threonine phosphatase, was highly expressed in human periprosthetic interface membranes with aseptic loosening and in a murine osteolysis model induced by titanium particle irritation. PP2A inhibition effectively alleviated titanium particle-induced bone destruction at osteolytic sites...
June 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29599034/clinical-outcomes-and-bearing-specific-complications-following-fourth-generation-alumina-ceramic-on-ceramic-total-hip-arthroplasty-a-single-surgeon-series-of-749-hips-at-a-minimum-of-5-year-follow-up
#13
Seung-Jae Lim, Hyung-Gon Ryu, Hyeon-Jun Eun, Chan-Woo Park, Kyeu-Back Kwon, Youn-Soo Park
BACKGROUND: The purpose of this study is to evaluate the minimum 5-year outcomes and bearing-specific complications in a single surgeon series of fourth-generation alumina ceramic-on-ceramic total hip arthroplasties (THAs). METHODS: We retrospectively analyzed 667 patients (749 hips) who underwent primary THAs by a single surgeon using fourth-generation alumina ceramic bearings. There were 315 men and 352 women with a mean age of 54.2 years. The surgeon used cementless prostheses with an identical design and BIOLOX Delta ceramics in all hips, using a 36-mm head in 472 hips (63%) and a 32-mm head in 227...
February 17, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29588121/large-metal-heads-and-highly-cross-linked-polyethylene-provide-low-wear-and-complications-at-5-13-years
#14
Paul F Lachiewicz, Jane A O'Dell, John M Martell
BACKGROUND: Highly cross-linked polyethylene (XLPE) is reported to have low rates of linear and volumetric wear at 10-14 years. In a prior study, larger (36 and 40 mm) femoral heads were associated with more volumetric wear, but there were only 12 hips with these heads. METHODS: We evaluated 107 hips (93 patients, with a mean age of 76 years) with one design of uncemented acetabular component, a 36 (90 hips) or 40 mm (17 hips) metal femoral head, and one electron beam 100 kGy irradiated and remelted XLPE at a mean follow-up of 8 years (range 5-13 years)...
February 23, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29570759/using-ceramic-on-ceramic-bearings-in-total-hip-arthroplasty-necessitating-44-or-46-mm-metal-shells
#15
Chan Ho Park, Yong-Chan Ha, Young-Kyun Lee, Kyung-Hoi Koo
Ceramic-on-ceramic articulation shows the lowest wear, with a low incidence of osteolysis. A small cup limits options regarding liner thickness and femoral implant size. The purpose of this study was to evaluate the safety of a 4-mm-thick ceramic liner and the outcomes of cementless total hip arthroplasty using a 44- or 46-mm metal shell and a ceramic-on-ceramic bearing at mid- to long-term follow-up. Between May 2003 and June 2008, 80 patients (88 hips) who had hip osteoarthritis and a hypoplastic acetabulum underwent cementless total hip arthroplasty using a 44- or 46-mm metal shell and a ceramic-on-ceramic bearing...
May 1, 2018: Orthopedics
https://www.readbyqxmd.com/read/29536681/-effect-of-ceramic-on-ceramic-total-hip-arthroplasty-in-crowe-iv-developmental-dysplasia-of-the-hip
#16
Jing-Yang Sun, Yong-Gang Zhou, Yin-Qiao Du, Shang Piao, Sen Wang, Zhi-Sen Gao, Wen-Ming Wu, Hai-Yang Ma
OBJECTIVE: To observe the clinical effect of ceramic on ceramic total hip arthroplasty(THA)in Crowe IV developmental dysplasia of the hip(DDH). METHODS: From April 2008 to December 2015, 137 hips of 111 Crowe IV DDH patients received THA using Forte or Delta ceramic on ceramic by one senior surgeon, which consists of 85 unilateral hips and 26 bilateral hips. The average age of the patients was(38.88±10.83) years old ranging from 18 to 68 years old. The mean follow-up was(41...
February 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29529704/early-experience-with-a-short-tapered-titanium-porous-plasma-sprayed-stem-with-updated-design
#17
Adolph V Lombardi, Antonio G Manocchio, Keith R Berend, Michael J Morris, Joanne B Adams
INTRODUCTION: Short stem femoral components in primary total hip arthroplasty (THA) have increased in popularity since the advent of minimally invasive surgical techniques. The concept of a short stem is particularly compatible with tapered designs where the goal is to offload forces proximally in the femur. The purpose of this retrospective review was to review our early experience with a short, tapered titanium femoral component with updated design features. MATERIALS AND METHODS: Beginning in November 2011 through February 2012, 92 consented patients (93 hips), at a single center, were treated with primary cementless THA using a short stem, tapered femoral component (Taperloc® Complete Microplasty; Zimmer Biomet, Warsaw, Indiana) and were available for review with a minimum two-year follow-up...
March 12, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29504054/higher-prevalence-of-periprosthetic-fractures-with-ceramic-on-polyethylene-hip-bearing-compared-with-ceramic-on-ceramic-on-the-contralateral-side-a-forty-year-experience-with-hip-osteonecrosis
#18
Philippe Hernigou, Jean Charles Auregan, Claire Bastard, Victor Housset, Charles Henri Flouzat-Lachaniette, Arnaud Dubory
PURPOSE: It is unclear whether late THA periprosthetic femoral fractures are related to a mechanical mechanism that decreases strength of the femur (for example, loosening) or to a biological problem as osteolysis. It is also unknown if ceramic on ceramic bearing couples decrease the risk of late periprosthetic fractures as a result of the absence of wear and osteolysis. MATERIAL AND METHODS: We therefore asked whether the cumulative long-term fractures were different according to the couple of friction ceramic on ceramic or ceramic on polyethylene in 327 patients (654 hips) with bilateral THA (one ceramic-ceramic, and the contralateral ceramic-polyethylene) who had THA with cemented stems performed between from 1978 to 2000 for osteonecrosis...
March 4, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29470416/carbon-fibre-reinforced-sic-composite-c-sisic-as-an-alternative-material-for-endoprosthesis-fabrication-mechanical-and-in-vitro-biological-properties
#19
Aline Reichert, Michael Seidenstuecker, Rainer Gadow, Hermann O Mayr, Norbert P Suedkamp, Sergio H Latorre, Partick Weichand, Anke Bernstein
Particle-induced periprosthetic osteolysis and subsequent aseptic implant loosening are a major cause of compromising the long-term results of total joint replacements. To date, no implant has been able to mirror radically the tribological factors (friction/lubrication/wear) of in vivo tribological pairings. Carbon-Fibre Reinforced SiC-Composites (C/SiSiC), a material primarily developed for brake technology, has the opportunity to fulfil this requirement. Until now, the material itself has not been used in medicine...
February 22, 2018: Materials
https://www.readbyqxmd.com/read/29469804/early-results-of-total-hip-arthroplasty-using-dual-mobility-cup-in-patients-with-osteonecrosis-of-the-femoral-head
#20
Chahine Assi, Nadim Kheir, Camille Samaha, Pascal Kouyoumjian, Kaissar Yammine
INTRODUCTION: Osteonecrosis of the femoral head (ONFH) remains a therapeutic challenge for patients undergoing total hip arthroplasty (THA). The majority of these patients are young with high functional demand, and show an increased risk of dislocation following surgery than patients with osteoarthritis. The use of double mobility cup (DMC) has been linked with lower rates of complications when compared to conservative cups; however, the literature is scarce over DMC results in patients with ONFH...
2018: SICOT-J
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