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Periprosthetic osteolysis

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https://www.readbyqxmd.com/read/28384949/comparative-study-of-surgical-management-of-fracture-neck-of-femur-with-cemented-versus-uncemented-bipolar-hemiarthroplasty
#1
Y S Prashanth, M Niranjan
INTRODUCTION: There is evidence for use of cemented hemiarthroplasty resulting in greater anchoring and lesser peri prosthetic fracture. However, this procedure results in more haemodynamic instability and cardiopulmonary complications termed as 'cement reaction' or bone cement implantation syndrome. There has been a heightened interest among surgeons to compare cemented and uncemented hemiarthroplasty for fracture neck of femur. AIM: To compare cemented and uncemented hemiarthroplasty in terms of blood loss during the procedure, post-operative complications, mortality, functional recovery and long term clinical outcome...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28384530/notoginsenoside-r1-suppresses-wear-particle-induced-osteolysis-and-rankl-mediated-osteoclastogenesis-in-vivo-and-in-vitro
#2
Shuai Zhao, Lianqi Yan, Xiaolei Li, Zhen Zhang, Yu Sun, Jingcheng Wang
Aseptic periprosthetic osteolysis is a complication induced by wear particles after hip joint replacement, which shortens the service life of prostheses. Although many methods have been applied to prevent this complication, the results were not always successful. In the present study, we explored the prophylactic effect of notoginsenoside R1 (NG-R1) on a Ti particle-induced mouse calvarial osteolysis model and the inhibitory effect on RANKL-mediated osteoclastogenesis and osteoclast bone resorption. Our results indicated that intraperitoneal injection of NG-R1(10 or 20mg/kg/day), a constituent of notoginseng, alleviates Ti particle-induced mouse calvarial osteolysis after twelve days post-treatment...
April 3, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28382864/microrna-130b-promotes-wear-particle-induced-osteolysis-via-downregulating-frizzled-related-protein-frzb
#3
De-Zhi Zheng, Yan-Min Bu, Lei Wang, Jun Liu
Periprosthetic osteolysis induced by wear particles can lead to aseptic loosening, one main reason of arthroplasty failure. However, the role of microRNA-130b (miR-130b) in particle-induced osteolysis (PIO) has not been explored yet. In this study, PIO models were established in C57BL/J6 mice via the implantation of Co-Cr-Mo alloy particles, and evaluated by detecting tartrate-resistant acid phosphatase (TRAP) activity and bone resorption in the calvaria. Mouse preosteoblast MC3T3-E1 cells were cultured to receive particle stimulation in vitro...
2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/28345781/apoptotic-pathways-of-macrophages-within-osteolytic-interface-membrane-in-periprosthestic-osteolysis-after-total-hip-replacement
#4
Guoyin Liu, Ting Guo, Yong Zhang, Naicheng Liu, Jiangning Chen, Jianmin Chen, Junfeng Zhang, Jianning Zhao
Macrophage apoptosis in interface membrane, which occurs through either death receptor, mitochondrion, or endoplasmic reticulum (ER) stress pathways, has been suggested to play an important role in promoting osteolysis. However, how and why macrophage apoptosis originates and the correlation among these apoptotic pathways is not yet clear. The objective of this study was to identify the apoptotic mechanism of macrophages, and to explore the relationship between the apoptotic pathways and progression of osteolysis...
March 27, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28291177/long-term-outcomes-of-reverse-total-shoulder-arthroplasty-a-follow-up-of-a-previous-study
#5
Guillaume Bacle, Laurent Nové-Josserand, Pascal Garaud, Gilles Walch
BACKGROUND: Despite the increasing numbers of reverse total shoulder arthroplasty (RTSA) procedures, the long-term results have been rarely reported. We previously reported early outcomes of a cohort of patients treated with a Grammont-style RTSA. The purpose of this study was to evaluate the outcomes after a minimum of 10 years, and to document prosthetic survival and complications. METHODS: Clinical outcome assessment was based on the absolute and relative Constant scores and the active range of motion...
March 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28262457/trochantoplasty-for-total-hip-arthroplasty-in-patients-with-coxa-vara-deformity
#6
Jun-Il Yoo, Javad Parvizi, Ji-Ung Song, Yong-Chan Ha, Young-Kyun Lee, Kyung-Hoi Koo
BACKGROUND: In total hip arthroplasty (THA) of hips with coxa vara, the femoral stems might be inserted in a varus alignment. To avoid varus insertion, we designed a technique, which we termed "trochantoplasty." In this procedure, the medial half of the greater trochanter was removed during THA. METHODS: We evaluated 30 patients (31 hips) who had coxa vara deformity and underwent THA using trochantoplasty at the mean follow-up of 5 years (range, 3-9 years). RESULTS: All stems were inserted in the neutral position...
February 14, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28215222/nf-%C3%AE%C2%BAb-as-a-therapeutic-target-in-inflammatory-associated-bone-diseases
#7
T-H Lin, J Pajarinen, L Lu, A Nabeshima, L A Cordova, Z Yao, S B Goodman
Inflammation is a defensive mechanism for pathogen clearance and maintaining tissue homeostasis. In the skeletal system, inflammation is closely associated with many bone disorders including fractures, nonunions, periprosthetic osteolysis (bone loss around orthopedic implants), and osteoporosis. Acute inflammation is a critical step for proper bone-healing and bone-remodeling processes. On the other hand, chronic inflammation with excessive proinflammatory cytokines disrupts the balance of skeletal homeostasis involving osteoblastic (bone formation) and osteoclastic (bone resorption) activities...
2017: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/28209339/vitamin-e-stabilized-highly-crosslinked-polyethylenes-the-role-and-effectiveness-in-total-hip-arthroplasty
#8
Kengo Yamamoto, Toshiyuki Tateiwa, Yasuhito Takahashi
Morphology and design of ultra-high molecular weight polyethylene (UHMWPE or simply PE) acetabular components used in total hip arthroplasty (THA) have been evolving for more than half a century. Since the late-1990s, there were two major technological innovations in PE emerged from necessity to overcome the wear-induced periprosthetic osteolysis, i.e., the development of highly crosslinked PEs (HXLPEs). There are many literature reporting that radiation crosslinked and remelted/annealed (first-generation) HXLPEs markedly reduced the incidence of osteolysis and aseptic loosening...
February 10, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28197150/curcumin-attenuates-titanium-particle-induced-inflammation-by-regulating-macrophage-polarization-in-vitro-and-in-vivo
#9
Bin Li, Yan Hu, Yaochao Zhao, Mengqi Cheng, Hui Qin, Tao Cheng, Qiaojie Wang, Xiaochun Peng, Xianlong Zhang
Periprosthetic inflammatory osteolysis and subsequent aseptic loosening are commonly observed in total joint arthroplasty. Other than revision surgery, few approved treatments are available for this complication. Wear particle-induced inflammation and macrophage polarization state play critical roles in periprosthetic osteolysis. We investigated the effects of curcumin, a polyphenol extracted from Curcuma longa, on titanium (Ti) particle-induced inflammation and macrophage polarization in vitro using the murine cell line RAW 264...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28150224/isolated-acetabular-revision-with-femoral-stem-retention-after-bipolar-hip-arthroplasty
#10
Nobuhiro Kaku, Tomonori Tabata, Hiroaki Tagomori, Hiroshi Tsumura
INTRODUCTION: In bipolar hemiarthroplasty, migration of the outer cup component into the acetabular cup, with evidence of severe osteolysis in the acetabulum, commonly occurs without loosening of the femoral component. The merits of retaining the stable femoral component in these cases have been debated. Our study aimed to determine whether revision of the acetabular component in isolation could be successfully performed. MATERIALS AND METHODS: The data of 54 patients (61 hips), 44 women, and 10 men, aged 67...
February 1, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28127738/the-role-of-rankl-rank-opg-system-in-the-canine-model-of-hip-periprosthetic-infection-osteolysis
#11
Hao-Wei Zhang, Li Peng, Wen-Bo Li, Ke-Guan Song
PURPOSE: We aimed to investigate whether the RANKL/RANK/OPG system is associated with the incidence of periprosthetic osteolysis with septic loosening, and to investigate the differences of RANKL/RANK/OPG system expression in synovial fluid surrounding the normal and septic loosening hip prosthesis in canine models. METHODS: Twelve healthy adult mongrel canines were divided into two groups: experimental and control. Femoral head and stem replacements were conducted on the right side in both groups...
January 24, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28114216/11r-vivit-peptide-inhibits-calvaria-osteolysis-induced-by-experimental-design
#12
Maoqiang Li, Liulong Zhu, Xuepeng Wang, Zhenyu Bian, Wangxiang Yao, Qifang He, Fei Tian
Wear particles released from prosthetic implants can cause periprosthetic osteolysis, a major cause of implant loosening. The aim of this study was to investigate the effects of the 11R-VIVIT peptide on osteolysis induced by titanium (Ti) particles in vivo. Twenty-four C57BL/J6 mice were divided into 3 groups: sham operation, Ti group, and Ti/VIVIT group. A calvarial osteolysis model was established by implanting Ti particles into mouse calvaria of the Ti and Ti/VIVIT groups. After 2 weeks, 11R-VIVIT peptide (10 mg/kg/day) was intraperitoneally injected into the mice of the Ti/VIVIT group for 14 days...
March 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28076890/suppression-of-osteogenic-activity-by-regulation-of-wnt-and-bmp-signaling-during-titanium-particle-induced-osteolysis
#13
Ju-Suk Nam, Ashish Ranjan Sharma, Supriya Jagga, Dong-Hyun Lee, Garima Sharma, Lich Thi Nguyen, Yeon Hee Lee, Jun-Dong Chang, Chiranjib Chakraborty, Sang-Soo Lee
Periprosthetic osteolysis remains the leading obstacle for total joint replacements. Primarily, it was thought that aseptic loosening is mainly caused by macrophage mediated inflammatory process arising from production of wear debris. The role of osteoclasts and its sequential bone resorption ability has been extensively studied, but little is known about impaired osteogenesis during osteolysis. In the current study, we have tried to delineate the regulatory mechanism of osteogenic signals by Ti particles in osteoprogenitor cells as well its participatory role in wear debris induced osteolysis...
March 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28059080/scaling-of-titanium-implants-entrains-inflammation-induced-osteolysis
#14
Michal Eger, Nir Sterer, Tamar Liron, David Kohavi, Yankel Gabet
With millions of new dental and orthopedic implants inserted annually, periprosthetic osteolysis becomes a major concern. In dentistry, peri-implantitis management includes cleaning using ultrasonic scaling. We examined whether ultrasonic scaling releases titanium particles and induces inflammation and osteolysis. Titanium discs with machined, sandblasted/acid-etched and sandblasted surfaces were subjected to ultrasonic scaling and we physically and chemically characterized the released particles. These particles induced a severe inflammatory response in macrophages and stimulated osteoclastogenesis...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28043711/total-hip-arthroplasty-with-a-fully-hydroxyapatite-coated-stem-a-cohort-study-during-23-28-years
#15
Olav Reikerås
BACKGROUND: Long-term results of a hydroxyapatite (HA)-coated stem are sparse. We have followed a cohort of patients operated with a grit-blasted titanium stem designed for press-fit insertion and entirely plasma-sprayed with HA up to 28 years. METHODS: In the years 1988-1993, we performed 323 primary total hip arthroplasties in 276 patients (189 women). Their mean age was 48 (15-79) years. During the following years, 83 patients with 88 hips have died, and 18 patients did not attend the follow-up examination, but had no major symptoms according to telephone interviews and control examination...
December 18, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28027386/paresis-of-the-peroneal-nerve-a-rare-but-severe-long-term-complication-of-polyethylene-wear-in-knee-arthroplasty
#16
Matthias Aurich, Mark Lenz, Norman Best
One of the most important limiting factors in the long-term success of total knee arthroplasty is polyethylene wear. Particles of the polyethylene inserts have been shown to elicit a foreign body response, which produces bone resorption and osteolysis, ultimately leading to loosening and component failure. The authors report on a case of an elderly patient who underwent a total knee arthroplasty almost 2 decades ago. Clinical and radiological checkups of the knee had not been performed recently. He now presented with a painful and swollen knee, recurrent joint effusion and swelling of the lower leg, and paresis of the peroneal nerve...
December 27, 2016: Orthopedics
https://www.readbyqxmd.com/read/28004128/-endoprosthesis-failure-in-the-ankle-joint-histopathological-diagnostics-and-classification
#17
S Müller, M Walther, A Röser, V Krenn
INTRODUCTION: Endoprostheses of the ankle joint show higher revision rates of 3.29 revisions per 100 component years. The aims of this study were the application and modification of the consensus classification of the synovia-like interface membrane (SLIM) for periprosthetic failure of the ankle joint, the etiological clarification of periprosthetic pseudocysts and a detailed measurement of proliferative activity (Ki67) in the region of osteolysis. MATERIAL AND METHOD: Tissue samples from 159 patients were examined according to the criteria of the standardized consensus classification...
December 21, 2016: Der Orthopäde
https://www.readbyqxmd.com/read/27998657/the-relationship-between-polyethylene-wear-and-periprosthetic-osteolysis-in-total-hip-arthroplasty-at-12-years-in-a-randomized-controlled-trial-cohort
#18
John A J Broomfield, Tamer T Malak, Geraint E R Thomas, Antony J R Palmer, Adrian Taylor, Sion Glyn-Jones
BACKGROUND: Polyethylene acetabular components are common in hip arthroplasty. Highly cross-linked polyethylene (HXLPE) has lower wear than ultra-high molecular weight polyethylene (UHMWPE). Evidence suggests that wear particles induce inflammation causing periprosthetic osteolysis contributing to implant loosening with wear rates of 0.05 mm/y were considered safe. We aimed to compare incidence and volume of periacetabular osteolysis between HXLPE and UHMWPE using computed tomography...
November 8, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27977880/mesenchymal-stem-cells-in-the-aseptic-loosening-of-total-joint-replacements
#19
REVIEW
Jukka Pajarinen, Tzu-Hua Lin, Akira Nabeshima, Eemeli Jämsen, Laura Lu, Karthik Nathan, Zhenyu Yao, Stuart B Goodman
Peri-prosthetic osteolysis remains as the main long-term complication of total joint replacement surgery. Research over four decades has established implant wear as the main culprit for chronic inflammation in the peri-implant tissues and macrophages as the key cells mediating the host reaction to implant-derived wear particles. Wear debris activated macrophages secrete inflammatory mediators that stimulate bone resorbing osteoclasts; thus bone loss in the peri-implant tissues is increased. However, the balance of bone turnover is not only dictated by osteoclast-mediated bone resorption but also by the formation of new bone by osteoblasts; under physiological conditions these two processes are tightly coupled...
April 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27890011/microrna-mir-130b-promotes-wear-particle-induced-osteolysis-via-down-regulating-frizzled-related-protein-frzb
#20
De-Zhi Zheng, Lei Wang, Yan-Min Bu, Jun Liu
Periprosthetic osteolysis induced by wear particles can lead to aseptic loosening, one main reason of arthroplasty failure. However, the role of microRNA-130b (miR-130b) in particle-induced osteolysis (PIO) has not been explored yet. In this study, PIO models were established in C57BL/J6 mice via the implantation of Co-Cr-Mo alloy particles, and evaluated by detecting tartrate-resistant acid phosphatase (TRAP) activity and bone resorption in the calvaria. Mouse preosteoblast MC3T3-E1 cells were cultured to receive particle stimulation in vitro...
November 23, 2016: Current Neurovascular Research
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