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Periprosthetic osteolysis

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https://www.readbyqxmd.com/read/28681916/luteoloside-prevents-lipopolysaccharide-induced-osteolysis-and-suppresses-rankl-induced-osteoclastogenesis-through-attenuating-rankl-signaling-cascades
#1
Fangming Song, Chengming Wei, Lin Zhou, A N Qin, Mingli Yang, Jennifer Tickner, Yuanjiao Huang, Jinmin Zhao, Jiake Xu
Bone destruction or osteolysis marked by excessive osteoclastic bone resorption is a very common medical condition. Identification of agents that can effectively suppress excessive osteoclast formation and function is crucial for prevention and treatment of osteolytic conditions such as periprosthetic joint infection and periprosthetic loosening. Luteoloside, a flavonoid, is a natural bioactive compound with anti-inflammation and anti-tumor properties. However, the effect of Luteoloside on inflammation-induced osteolysis is unknown...
July 6, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28665453/good-mid-term-clinical-results-of-a-cemented-dual-mobility-cup-a-single-centre-experience
#2
Gregor Kavčič, Pika Mirt, Klemen Bedenčič
INTRODUCTION AND METHODS: From January 2004 to December 2008, 188 total hip arthroplasties were performed using a cemented dual mobility cup. 174 patients were available for final analysis. Their mean age was 76.8 (range 54-98 years). The mean follow-up was 7.7 years (range 5-10 years). RESULTS: There were no dislocations. Survivorship rates of the femoral and acetabular components were 100% at a minimum of 5 years. At the latest follow-up, the mean Harris Hip Score significantly increased from 31...
June 19, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28660436/adventure-sports-and-sexual-freedom-hip-replacement-the-tripolar-hip
#3
James W Pritchett
Certain athletic activities and lifestyles require a completely stable and very mobile hip. Total hip replacement with a natural femoral head size and two mobile-bearing surfaces (i.e., a "tripolar" prosthesis) is the most stable prosthesis. Elegant design and wear-resistant bearing surfaces are the keys to long-term implant survivorship. The hypothesis is that a ceramic-coated tripolar prosthesis using highly cross-linked polyethylene can provide full function and complete stability with low wear. This study sought to determine: (1) patient-reported outcomes, (2) functional outcomes, (3) implant survivorship and complications, and (4) postoperative sexual limitations...
June 28, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28648703/osteoclasts-in-periprosthetic-osteolysis-the-charnley-arthroplasty-revisited
#4
Sebastian S Mukka, Göran N Andersson, Kjell R Hultenby, Olof G Sköldenberg, Joakim P Nordahl, Thomas M Eisler
BACKGROUND: Periprosthetic osteolysis by polyethylene wear debris-triggered osteoclasts is viewed as the main pathophysiological pathway in aseptic loosening in total hip arthroplasty. The present aim was to study osteoclast occurrence in osteolytic lesions in early and late revisions of the Charnley low-friction torque arthroplasty (CLFA). METHODS: Biopsies of the soft interface membrane and the adjacent bone were taken from osteolytic lesions during revision of 16 loose CLFA, early (2-6 years) or late (>10 years) after primary surgery...
May 22, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28637383/inflammation-induced-osteogenesis-in-a-rabbit-tibia-model
#5
Michiel Croes, Willemijn Boot, Moyo C Kruyt, Harrie Weinans, Behdad Pouran, Yvonne van der Helm, Debby Gawlitta, Charles Vogely, Jacqueline Alblas, Wouter Dhert, F Cumhur Oner
Pathologic conditions associated with bone formation can serve as models to identify bone-promoting mediators. The inflammatory response to bacterial infections generally leads to osteolysis and impaired bone healing, but paradoxically, it can also have pro-osteogenic effects. As a potential model to investigate pro-osteogenic stimuli, this study characterizes the bone formation in an established rabbit tibia model of periprosthetic infection. Our hypothesis was that the infection with Staphylococcus aureus (S...
June 22, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28587888/outcome-of-4-surgical-treatments-for-wear-and-osteolysis-of-cementless-acetabular-components
#6
Rapeepat Narkbunnam, Derek F Amanatullah, Ali J Electriwala, James I Huddleston, William J Maloney, Stuart B Goodman
BACKGROUND: Loosening and periprosthetic osteolysis are some of the most common long-term complications after hip arthroplasty. The decision-making process and surgical treatment options are controversial. METHODS: We retrospectively reviewed 96 acetabular revisions (91 patients) performed between 2002 and 2012, with a minimum of 2 years of follow-up and a mean of 5.7 years of follow-up. Clinical outcome was assessed using the Harris Hip Score. The size and location of osteolytic lesions were evaluated using the preoperative radiographs; healing of the defects was categorized using a standardized protocol...
April 27, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28579445/clinical-and-radiographic-outcomes-of-total-hip-arthroplasty-with-a-specific-liner-in-small-asian-patients-influence-of-patient-related-implant-related-and-surgical-factors-on-femoral-head-penetration
#7
Hirofumi Oshima, Sakae Tanaka, Yoshio Takatori, Takeyuki Tanaka, Hisatoshi Ishikura, Toru Moro
BACKGROUND: We evaluated the clinical and radiographic outcomes, including femoral head penetration, of total hip arthroplasty performed using a specific polyethylene (PE) liner in small Asian patients at 10 years after the index surgery. In addition, we investigated whether femoral head penetration was affected by patient-related, implant-related, and surgical factors. METHODS: Between August 2002 and June 2005, for cementless primary total hip arthroplasty, we used acetabular PE liners that were manufactured from GUR 1050 resin, machined from isostatic compression-molded bar stock, and sterilized with a gamma ray irradiation in argon gas...
May 4, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28578796/are-periprosthetic-osteolytic-lesions-in-ankle-worth-bone-grafting
#8
Ia Kohonen, Helka Koivu, Hannu Tiusanen, Jussi Kankare, Tero Vahlberg, Kimmo Mattila
BACKGROUND: We retrospectively evaluated the medium-term follow-up of bone grafting due to periprosthetic osteolytic lesions in ankles. METHODS: 34 ankles (32 patients) with total ankle arthroplasty (TAA) underwent re operation. Indications were large periprosthetic osteolytic lesions or continuous growing of the lesions. The osteolytic lesions were imaged by CT before reoperation and once a year after that. The mean CT follow-up after re operation was 3.8 years (range, 2-6...
June 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28566392/mid-term-results-of-the-biolox-delta-ceramic-on-ceramic-total-hip-arthroplasty
#9
Y K Lee, Y C Ha, J-I Yoo, W L Jo, K-C Kim, K H Koo
AIMS: We conducted a prospective study of a delta ceramic total hip arthroplasty (THA) to determine the rate of ceramic fracture, to characterise post-operative noise, and to evaluate the mid-term results and survivorship. PATIENTS AND METHODS: Between March 2009 and March 2011, 274 patients (310 hips) underwent cementless THA using a delta ceramic femoral head and liner. At each follow-up, clinical and radiological outcomes were recorded. A Kaplan-Meier analysis was undertaken to estimate survival...
June 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28529108/a-3-to-18-year-follow-up-of-revision-total-hip-arthroplasty-with-impacted-bone-allografts-and-cemented-lubinus-sp-ii-stem-clinical-radiographic-and-survivorship-analysis-with-comparison-to-the-literature
#10
Hampus Stigbrand, Gösta Ullmark
BACKGROUND: We present the first medium- to long-term follow-up of revision total hip arthroplasty using impaction bone grafting (IBG) combined with the matte and collared Lubinus SP II stem for cases of severe osteolysis and stem loosening. METHODS: Sixty-nine femoral revisions were identified for 67 patients consecutively operated with revision femoral arthroplasty using IBG and a cemented Lubinus SP II stem. The mean age was 69 years (standard deviation, 9.9)...
April 18, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28511839/the-implication-of-the-osteolysis-threshold-and-interfacial-gaps-on-periprosthetic-osteolysis-in-cementless-total-hip-replacement
#11
Hamidreza Alidousti, Neil W Bressloff
Osteolysis around joint replacements may develop due to migration of wear particles from the joint space into gaps between the interface bone and the implant where they can accumulate in high concentrations to cause tissue damage. Osteolysis may appear in various postoperative times and morphological shapes which can be generalized into linear and focal. However, there are no clear explanations on the causes of such variations. Patients' degree of sensitivity to polyethylene particles (osteolysis thresholds), the local particle concentration and the access route provided by the interface gaps have been described as determining factors...
June 14, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28502348/osteolysis-in-total-ankle-replacement-how-does-it-work
#12
REVIEW
Norman Espinosa, Georg Klammer, Stephan H Wirth
Aseptic loosening of implants remains the most common reason for revision surgery for hip, knee, or ankle prostheses. Although a great scientific effort has been made to explain the underlying mechanisms it remains poorly understood, complex, and multifactorial. Many factors, including age, body weight, activity lesions, implant design, fixation methods, material proprieties, immunologic responses, and biomechanical adaptations to total ankle replacement all contribute to the development of periprosthetic osteolysis...
June 2017: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/28500495/causes-for-early-and-late-surgical-re-intervention-after-radial-head-arthroplasty
#13
Pierre Laumonerie, David Ancelin, Nicolas Reina, Meagan E Tibbo, Panagiotis Kerezoudis, Stephanie Delclaux, Nicolas Bonnevialle, Pierre Mansat
PURPOSE: The primary objective was to describe the reasons for surgical re-intervention after radial head arthroplasty. The secondary objective was to analyze the radiographic and clinical outcomes after surgical re-intervention at the elbow with implant conservation. METHODS: Among the 70 radial head arthroplasties with bipolar radial head implant performed between 2002 and 2014, 29 required surgical re-interventions. Reasons for surgical re-intervention were gathered from operative notes and follow-up documentation...
May 12, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28459709/the-humeral-implant-in-shoulder-arthroplasty
#14
Jay D Keener, Peter Nissen Chalmers, Ken Yamaguchi
Humeral hemiarthroplasty, anatomic total shoulder arthroplasty, and reverse total shoulder arthroplasty all rely on a prosthetic articular surface fixed to the proximal humerus. Humeral implant designs have changed considerably as a result of improved understanding of proximal humeral anatomy and prosthetic biomechanics. Fixed, monoblock implants have been superseded by modular implants with variable inclination, offset, version, and stem length. Press-fit designs now commonly have surface coatings that allow bony ingrowth...
June 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28384949/comparative-study-of-surgical-management-of-fracture-neck-of-femur-with-cemented-versus-uncemented-bipolar-hemiarthroplasty
#15
Y S Prashanth, M Niranjan
INTRODUCTION: There is evidence for use of cemented hemiarthroplasty resulting in greater anchoring and lesser peri prosthetic fracture. However, this procedure results in more haemodynamic instability and cardiopulmonary complications termed as 'cement reaction' or bone cement implantation syndrome. There has been a heightened interest among surgeons to compare cemented and uncemented hemiarthroplasty for fracture neck of femur. AIM: To compare cemented and uncemented hemiarthroplasty in terms of blood loss during the procedure, post-operative complications, mortality, functional recovery and long term clinical outcome...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28384530/notoginsenoside-r1-suppresses-wear-particle-induced-osteolysis-and-rankl-mediated-osteoclastogenesis-in-vivo-and-in-vitro
#16
Shuai Zhao, Lianqi Yan, Xiaolei Li, Zhen Zhang, Yu Sun, Jingcheng Wang
Aseptic periprosthetic osteolysis is a complication induced by wear particles after hip joint replacement, which shortens the service life of prostheses. Although many methods have been applied to prevent this complication, the results were not always successful. In the present study, we explored the prophylactic effect of notoginsenoside R1 (NG-R1) on a Ti particle-induced mouse calvarial osteolysis model and the inhibitory effect on RANKL-mediated osteoclastogenesis and osteoclast bone resorption. Our results indicated that intraperitoneal injection of NG-R1(10 or 20mg/kg/day), a constituent of notoginseng, alleviates Ti particle-induced mouse calvarial osteolysis after twelve days post-treatment...
April 3, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28382864/microrna-130b-promotes-wear-particle-induced-osteolysis-via-downregulating-frizzled-related-protein-frzb
#17
De-Zhi Zheng, Yan-Min Bu, Lei Wang, Jun Liu
Periprosthetic osteolysis induced by wear particles can lead to aseptic loosening, one main reason of arthroplasty failure. However, the role of microRNA-130b (miR-130b) in particle-induced osteolysis (PIO) has not been explored yet. In this study, PIO models were established in C57BL/J6 mice via the implantation of Co-Cr-Mo alloy particles, and evaluated by detecting tartrate-resistant acid phosphatase (TRAP) activity and bone resorption in the calvaria. Mouse preosteoblast MC3T3-E1 cells were cultured to receive particle stimulation in vitro...
2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/28345781/apoptotic-pathways-of-macrophages-within-osteolytic-interface-membrane-in-periprosthestic-osteolysis-after-total-hip-replacement
#18
Guoyin Liu, Ting Guo, Yong Zhang, Naicheng Liu, Jiangning Chen, Jianmin Chen, Junfeng Zhang, Jianning Zhao
Macrophage apoptosis in interface membrane, which occurs through either death receptor, mitochondrion, or endoplasmic reticulum (ER) stress pathways, has been suggested to play an important role in promoting osteolysis. However, how and why macrophage apoptosis originates and the correlation among these apoptotic pathways is not yet clear. The objective of this study was to identify the apoptotic mechanism of macrophages, and to explore the relationship between the apoptotic pathways and progression of osteolysis...
June 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28291177/long-term-outcomes-of-reverse-total-shoulder-arthroplasty-a-follow-up-of-a-previous-study
#19
Guillaume Bacle, Laurent Nové-Josserand, Pascal Garaud, Gilles Walch
BACKGROUND: Despite the increasing numbers of reverse total shoulder arthroplasty (RTSA) procedures, the long-term results have been rarely reported. We previously reported early outcomes of a cohort of patients treated with a Grammont-style RTSA. The purpose of this study was to evaluate the outcomes after a minimum of 10 years, and to document prosthetic survival and complications. METHODS: Clinical outcome assessment was based on the absolute and relative Constant scores and the active range of motion...
March 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28262457/trochantoplasty-for-total-hip-arthroplasty-in-patients-with-coxa-vara-deformity
#20
Jun-Il Yoo, Javad Parvizi, Ji-Ung Song, Yong-Chan Ha, Young-Kyun Lee, Kyung-Hoi Koo
BACKGROUND: In total hip arthroplasty (THA) of hips with coxa vara, the femoral stems might be inserted in a varus alignment. To avoid varus insertion, we designed a technique, which we termed "trochantoplasty." In this procedure, the medial half of the greater trochanter was removed during THA. METHODS: We evaluated 30 patients (31 hips) who had coxa vara deformity and underwent THA using trochantoplasty at the mean follow-up of 5 years (range, 3-9 years). RESULTS: All stems were inserted in the neutral position...
February 14, 2017: Journal of Arthroplasty
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