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Periprosthetic osteolysis

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https://www.readbyqxmd.com/read/29656074/protein-phosphatase-2a-as-a-new-target-for-downregulating-osteoclastogenesis-and-alleviating-titanium-particle-induced-bone-resorption
#1
Liangliang Wang, Xiaobin Guo, Wei Zhou, Yayun Ding, Jiawei Shi, Xiexing Wu, Yu Liu, Yaozeng Xu, Huilin Yang, Dechun Geng
Receptor activator of nuclear factor-кB ligand (RANKL)-induced osteoclastogenesis is believed to play a critical role in osteolytic diseases including peri-prosthetic osteolysis (PPO), the primary reason for implant failure and revision surgery. In this study, we observed that protein phosphatase 2A (PP2A), a major serine-threonine phosphatase, was highly expressed in human periprosthetic interface membranes with aseptic loosening and in a murine osteolysis model induced by titanium particle irritation. PP2A inhibition effectively alleviated titanium particle-induced bone destruction at osteolytic sites...
April 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29599034/clinical-outcomes-and-bearing-specific-complications-following-fourth-generation-alumina-ceramic-on-ceramic-total-hip-arthroplasty-a-single-surgeon-series-of-749-hips-at-a-minimum-of-5-year-follow-up
#2
Seung-Jae Lim, Hyung-Gon Ryu, Hyeon-Jun Eun, Chan-Woo Park, Kyeu-Back Kwon, Youn-Soo Park
BACKGROUND: The purpose of this study is to evaluate the minimum 5-year outcomes and bearing-specific complications in a single surgeon series of fourth-generation alumina ceramic-on-ceramic total hip arthroplasties (THAs). METHODS: We retrospectively analyzed 667 patients (749 hips) who underwent primary THAs by a single surgeon using fourth-generation alumina ceramic bearings. There were 315 men and 352 women with a mean age of 54.2 years. The surgeon used cementless prostheses with an identical design and BIOLOX Delta ceramics in all hips, using a 36-mm head in 472 hips (63%) and a 32-mm head in 227...
February 17, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29588121/large-metal-heads-and-highly-cross-linked-polyethylene-provide-low-wear-and-complications-at-5-13-years
#3
Paul F Lachiewicz, Jane A O'Dell, John M Martell
BACKGROUND: Highly cross-linked polyethylene (XLPE) is reported to have low rates of linear and volumetric wear at 10-14 years. In a prior study, larger (36 and 40 mm) femoral heads were associated with more volumetric wear, but there were only 12 hips with these heads. METHODS: We evaluated 107 hips (93 patients, with a mean age of 76 years) with one design of uncemented acetabular component, a 36 (90 hips) or 40 mm (17 hips) metal femoral head, and one electron beam 100 kGy irradiated and remelted XLPE at a mean follow-up of 8 years (range 5-13 years)...
February 23, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29570759/using-ceramic-on-ceramic-bearings-in-total-hip-arthroplasty-necessitating-44-or-46-mm-metal-shells
#4
Chan Ho Park, Yong-Chan Ha, Young-Kyun Lee, Kyung-Hoi Koo
Ceramic-on-ceramic articulation shows the lowest wear, with a low incidence of osteolysis. A small cup limits options regarding liner thickness and femoral implant size. The purpose of this study was to evaluate the safety of a 4-mm-thick ceramic liner and the outcomes of cementless total hip arthroplasty using a 44- or 46-mm metal shell and a ceramic-on-ceramic bearing at mid- to long-term follow-up. Between May 2003 and June 2008, 80 patients (88 hips) who had hip osteoarthritis and a hypoplastic acetabulum underwent cementless total hip arthroplasty using a 44- or 46-mm metal shell and a ceramic-on-ceramic bearing...
March 23, 2018: Orthopedics
https://www.readbyqxmd.com/read/29536681/-effect-of-ceramic-on-ceramic-total-hip-arthroplasty-in-crowe-iv-developmental-dysplasia-of-the-hip
#5
Jing-Yang Sun, Yong-Gang Zhou, Yin-Qiao Du, Shang Piao, Sen Wang, Zhi-Sen Gao, Wen-Ming Wu, Hai-Yang Ma
OBJECTIVE: To observe the clinical effect of ceramic on ceramic total hip arthroplasty(THA)in Crowe IV developmental dysplasia of the hip(DDH). METHODS: From April 2008 to December 2015, 137 hips of 111 Crowe IV DDH patients received THA using Forte or Delta ceramic on ceramic by one senior surgeon, which consists of 85 unilateral hips and 26 bilateral hips. The average age of the patients was(38.88±10.83) years old ranging from 18 to 68 years old. The mean follow-up was(41...
February 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29529704/early-experience-with-a-short-tapered-titanium-porous-plasma-sprayed-stem-with-updated-design
#6
Adolph V Lombardi, Antonio G Manocchio, Keith R Berend, Michael J Morris, Joanne B Adams
INTRODUCTION: Short stem femoral components in primary total hip arthroplasty (THA) have increased in popularity since the advent of minimally invasive surgical techniques. The concept of a short stem is particularly compatible with tapered designs where the goal is to offload forces proximally in the femur. The purpose of this retrospective review was to review our early experience with a short, tapered titanium femoral component with updated design features. MATERIALS AND METHODS: Beginning in November 2011 through February 2012, 92 consented patients (93 hips), at a single center, were treated with primary cementless THA using a short stem, tapered femoral component (Taperloc® Complete Microplasty; Zimmer Biomet, Warsaw, Indiana) and were available for review with a minimum two-year follow-up...
March 12, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29504054/higher-prevalence-of-periprosthetic-fractures-with-ceramic-on-polyethylene-hip-bearing-compared-with-ceramic-on-ceramic-on-the-contralateral-side-a-forty-year-experience-with-hip-osteonecrosis
#7
Philippe Hernigou, Jean Charles Auregan, Claire Bastard, Victor Housset, Charles Henri Flouzat-Lachaniette, Arnaud Dubory
PURPOSE: It is unclear whether late THA periprosthetic femoral fractures are related to a mechanical mechanism that decreases strength of the femur (for example, loosening) or to a biological problem as osteolysis. It is also unknown if ceramic on ceramic bearing couples decrease the risk of late periprosthetic fractures as a result of the absence of wear and osteolysis. MATERIAL AND METHODS: We therefore asked whether the cumulative long-term fractures were different according to the couple of friction ceramic on ceramic or ceramic on polyethylene in 327 patients (654 hips) with bilateral THA (one ceramic-ceramic, and the contralateral ceramic-polyethylene) who had THA with cemented stems performed between from 1978 to 2000 for osteonecrosis...
March 4, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29470416/carbon-fibre-reinforced-sic-composite-c-sisic-as-an-alternative-material-for-endoprosthesis-fabrication-mechanical-and-in-vitro-biological-properties
#8
Aline Reichert, Michael Seidenstuecker, Rainer Gadow, Hermann O Mayr, Norbert P Suedkamp, Sergio H Latorre, Partick Weichand, Anke Bernstein
Particle-induced periprosthetic osteolysis and subsequent aseptic implant loosening are a major cause of compromising the long-term results of total joint replacements. To date, no implant has been able to mirror radically the tribological factors (friction/lubrication/wear) of in vivo tribological pairings. Carbon-Fibre Reinforced SiC-Composites (C/SiSiC), a material primarily developed for brake technology, has the opportunity to fulfil this requirement. Until now, the material itself has not been used in medicine...
February 22, 2018: Materials
https://www.readbyqxmd.com/read/29469804/early-results-of-total-hip-arthroplasty-using-dual-mobility-cup-in-patients-with-osteonecrosis-of-the-femoral-head
#9
Chahine Assi, Nadim Kheir, Camille Samaha, Pascal Kouyoumjian, Kaissar Yammine
INTRODUCTION: Osteonecrosis of the femoral head (ONFH) remains a therapeutic challenge for patients undergoing total hip arthroplasty (THA). The majority of these patients are young with high functional demand, and show an increased risk of dislocation following surgery than patients with osteoarthritis. The use of double mobility cup (DMC) has been linked with lower rates of complications when compared to conservative cups; however, the literature is scarce over DMC results in patients with ONFH...
2018: SICOT-J
https://www.readbyqxmd.com/read/29457432/-micro-ct-evaluating-inhibitory-effect-of-zoledronic-acid-on-polyethylene-particle-induced-periprosthetic-osteolysis-model
#10
Lian-Guo Wu, Feng-Qing Wu, Hua Chen
OBJECTIVE: To observe inhibitory effect of zoledronic acid on polyethylene particle-induced periprosthetic osteolysis model. METHODS: Thirty male adult specific-pathogen-free SD rats (weighted 250 to 300 g) were randomly divided into sham group, model group, and zoledronic acid group, 10 in each group. Modeling were building by titanium screws and polyethylene particles implanted into right femur of rats, sham group and model group were performed hypodermic injection by 0...
December 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29451944/total-hip-arthroplasty-in-patients-with-avascular-necrosis-after-hematopoietic-stem-cell-transplantation
#11
Anita Vijapura, Harlan B Levine, Michele Donato, Mark A Hartzband, Melissa Baker, Gregg R Klein
The immunosuppressive regimens required for hematopoietic stem cell transplantation predispose recipients to complications, including avascular necrosis. Cancer-related comorbidities, immunosuppression, and poor bone quality theoretically increase the risk for perioperative medical complications, infection, and implant-related complications in total joint arthroplasty. This study reviewed 20 primary total hip arthroplasties for avascular necrosis in 14 patients. Outcomes were assessed at routine clinical visits and Harris hip scores were calculated...
February 16, 2018: Orthopedics
https://www.readbyqxmd.com/read/29409184/peri-prosthetic-bone-cysts-after-total-ankle-replacement-a-systematic-review-and-meta-analysis
#12
REVIEW
Joana Arcângelo, Francisco Guerra-Pinto, André Pinto, André Grenho, Alfons Navarro, Xavier Martin Oliva
BACKGROUND: Periprosthetic cystic osteolysis is a well-known complication of total ankle replacement. Several theories have been proposed for its aetiology, based on individual biomechanical, radiological, histopathology and outcome studies. METHODS: Studies that met predefined inclusion/exclusion criteria were analysed to identify literature describing the presence of peri-prosthetic ankle cystic osteolysis. Quantitative data from the selected articles were combined and statistically tested in order to analyse possible relations between ankle peri-prosthetic bone cysts and specific implant characteristics...
November 29, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29352728/differential-proteomic-analysis-of-synovial-fluid-from-hip-arthroplasty-patients-with-a-pseudotumor-vs-periprosthetic-osteolysis
#13
Isabelle Catelas, Eric A Lehoux, Zhibin Ning, Daniel Figeys, Stephen J Baskey, Paul E Beaulé
Adverse tissue reactions to metal implants, including pseudotumors, can compromise implant functionality and survivorship. The identification of specific proteins in the synovial fluid (SF) of hip arthroplasty patients with a pseudotumor may lead to a better understanding of the underlying pathomechanisms. The objective of the present study was to compare the protein content of SF from patients with a short-term metal-on-metal hip implant associated with a pseudotumor and patients with a long-term metal-on-polyethylene hip implant associated with periprosthetic osteolysis...
January 20, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29349968/-clinical-outcomes-of-total-hip-arthroplasty-using-wagner-sl-revision-stem-in-femoral-intertrochanteric-fractures-for-patients-with-old-fracture-or-painful-arthritis-before-injury
#14
Xian-Wu Chen, Ru-Qing Ye, Hai-Ping Xu
OBJECTIVE: To retrospectively study the clinical results of total hip arthroplasty(THA) using Wagner SL revision stem for patients with femoral intertrochanteric fracture. METHODS: From 2006 January to 2009 December, 29 consecutive patients with femoral intertrochanteric fractures were performed THA using Wagner SL revision stem and intertrochanteric reconstruction, including 18 males and 11 females with an average age of 49 years old ranging from 43 to 58. Among them, 8 cases were oboslete femoral intertrochanteric fractures and 21 cases were the intertrochanteric fractures with painful arthritis before injuries...
March 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349961/-total-hip-arthroplasty-for-post-traumatic-arthritis-after-internal-fixation-of-acetabular-fracture
#15
Xue-Jun An, Jie-Fu Song, Jie Wei, Yu-Ming Zhang, Yun-Xing Su
OBJECTIVE: To study the clinical outcome of total hip arthroplasty(THA) for traumatic arthritis after acetabular fracture. METHODS: From June 2010 to June 2014, 33 hips in 33 patients with traumatic arthritis after acetabular fracture were retrospective analyzed including 21 males and 12 females with a mean age of 44.6 years old. All the patients received THA with bio-prostheses. Harris score was used to evaluate the hip function of patients before and after operation, the X-ray was adopted for radiographic evaluation of the hip prosthesis...
March 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29342496/-adverse-events-in-the-treatment-of-periprosthetic-fractures-around-the-knee-a-clinical-and-radiological-outcome-analysis
#16
Anna Janine Schreiner, Christoph Gonser, Christoph Ihle, Max Konstantin Zauleck, Tim Klopfer, Fabian Stuby, Ulrich Stöckle, Björn Gunnar Ochs
BACKGROUND: The incidence of periprosthetic fractures associated with total knee arthroplasty (PpFxK) has been reported to be 0.3 - 5.5%. 40% of all cases are related to revision TKA. The most common localisation is the distal femur. Classification is performed according to Rorabeck (RB). RB I - II fractures are usually treated with locked plating and retrograde intramedullary nailing, whereas RB III fractures are an indication for revision arthroplasty using a hinged endoprosthesis...
January 17, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29338713/lncrna-dancr-involved-osteolysis-after-total-hip-arthroplasty-by-regulating-foxo1-expression-to-inhibit-osteoblast-differentiation
#17
Zhenyu Tang, Zongming Gong, Xiaoliang Sun
BACKGROUND: Aseptic loosening of artificial hip joint is a major complication affecting the long-term use of the artificial hip joint, and is the main cause of joint replacement failure. However, the mechanism of aseptic loosening of THR has not yet cleared. The aim of this study was to investigate the underlying mechanism of DANCR in osteoblast differentiation (OD). METHODS: We detected the expressions of DANCR and FOXO1 in clinical samples and mesenchymal stem cells (MSCs) by qRT-PCR and western blotting...
January 16, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29335894/management-of-periprosthetic-shoulder-infections-with-the-use-of-a-permanent-articulating-antibiotic-spacer
#18
Antonio Pellegrini, Claudio Legnani, Vittorio Macchi, Enzo Meani
INTRODUCTION: Management of periprosthetic shoulder infections (PSIs) still remains challenging. We conducted a retrospective case study to assess the outcomes of definitive articulating antibiotic spacer implantation in a cohort of elderly, low-demanding patients. We hypothesized that in patients with low functional demands seeking pain relief with chronic PSIs, treatment with a definitive articulating antibiotic spacer would lead to satisfying results concerning eradication of the infection, improvement of pain, and improving shoulder function...
January 15, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29313319/early-experience-with-a-tapered-titanium-porous-plasma-sprayed-stem-with-updated-design
#19
Antonio G Manocchio, Keith R Berend, Michael J Morris, Joanne B Adams, Adolph V Lombardi
INTRODUCTION: The Taperloc® Complete femoral stem (Zimmer Biomet, Warsaw, Indiana) builds on the widespread clinical success of the original Taperloc design used since 1982. Enhancements to the Complete design include a lowered caput-collum-diaphyseal (CCD) angle from 138° to 133° for improved offset, optimized neck taper with polished neck flats to increase range of motion, reduced distal geometry to improve proximal canal fill, and gradual off-loading that is the goal of tapered geometry...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29246716/clinical-performance-patient-reported-outcome-and-radiological-results-of-a-short-tapered-porous-proximally-coated-cementless-femoral-stem-results-up-to-seven-years-of-follow-up
#20
Michele Ulivi, Luca C Orlandini, Valentina Meroni, Michele D M Lombardo, Giuseppe M Peretti
BACKGROUND: The primary aim of our study was to assess clinical performance, patient reported outcome and radiological results of cementless primary total hip arthroplasty using Tri-Lock Bone Preservation Stem. METHODS: Between March 2010 and June 2012, 163 consecutive patients, were enrolled in the study. Patients were assessed clinically and radiographically prior to surgery as well as at 6, 12, 24 months and then at 5, 6, and 7 years postoperatively. RESULTS: Using the Dorr classification, 39 patients (23...
April 2018: Journal of Arthroplasty
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