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Periprosthetic osteolysis

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https://www.readbyqxmd.com/read/29218618/metal-artifact-reduction-mri-of-total-ankle-arthroplasty-implants
#1
Cesar de Cesar Netto, Lucas F Fonseca, Benjamin Fritz, Steven E Stern, Esther Raithel, Mathias Nittka, Lew C Schon, Jan Fritz
OBJECTIVES: To assess high-bandwidth and compressed sensing-(CS)-SEMAC turbo spin echo (TSE) techniques for metal artifact reduction MRI of total ankle arthroplasty (TAA) implants. METHODS: Following institutional approval and consent, 40 subjects with TAA implants underwent 1.5-T MRI prospectively. Evaluations included bone-implant interfaces, anatomical structures, abnormal findings and differential diagnoses before and after MRI. AUCs of P-P plots were used to determine superiority...
December 7, 2017: European Radiology
https://www.readbyqxmd.com/read/29212681/ten-year-follow-up-study-of-three-alternative-bearing-surfaces-used-in-total-hip-arthroplasty-in-young-patients-a-prospective-randomised-controlled-trial
#2
A Atrey, S E Ward, A Khoshbin, N Hussain, E Bogoch, E H Schemitsch, J P Waddell
AIMS: We present the ten-year data of a cohort of patients, aged between 18 and 65 years (mean age 52.7 years; 19 to 64), who underwent total hip arthroplasty. Patients were randomised to be treated with a cobalt-chrome (CoCr) femoral head with an ultra-high molecular weight polyethylene (UHMWPE), highly cross-linked polyethylene (XLPE) or ceramic-on-ceramic (CoC) bearing surface. PATIENTS AND METHODS: A total of 102 hips (91 patients) were randomised into the three groups...
December 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29212557/preconditioning-of-murine-mesenchymal-stem-cells-synergistically-enhanced-immunomodulation-and-osteogenesis
#3
Tzuhua Lin, Jukka Pajarinen, Akira Nabeshima, Laura Lu, Karthik Nathan, Eemeli Jämsen, Zhenyu Yao, Stuart B Goodman
BACKGROUND: Mesenchymal stem cells (MSCs) are capable of immunomodulation and tissue regeneration, highlighting their potential translational application for treating inflammatory bone disorders. MSC-mediated immunomodulation is regulated by proinflammatory cytokines and pathogen-associated molecular patterns such as lipopolysaccharide (LPS). Previous studies showed that MSCs exposed to interferon gamma (IFN-γ) and the proinflammatory cytokine tumor necrosis factor alpha (TNF-α) synergistically suppressed T-cell activation...
December 6, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29212390/serratiopeptidase-reduces-the-invasion-of-osteoblasts-by-staphylococcus-aureus
#4
Laura Selan, Rosanna Papa, Angela Ermocida, Andrea Cellini, Evaristo Ettorre, Gianluca Vrenna, Davide Campoccia, Lucio Montanaro, Carla Renata Arciola, Marco Artini
Finding new strategies to counteract periprosthetic infection and implant failure is a main target in orthopedics. Staphylococcus aureus, the leading etiologic agent of orthopedic implant infections, is able to enter and kill osteoblasts, to stimulate pro-inflammatory chemokine secretion, to recruit osteoclasts, and to cause inflammatory osteolysis. Moreover, by entering eukaryotic cells, staphylococci hide from the host immune defenses and shelter from the extracellular antibiotics. Thus, infection persists, inflammation thrives, and a highly destructive osteomyelitis occurs around the implant...
December 1, 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/29177774/surgical-treatment-of-periprosthetic-femoral-fractures-a-retrospective-study-with-functional-and-radiological-outcomes-from-2010-to-2016
#5
Gaetano Caruso, Lorenzo Milani, Tedi Marko, Vincenzo Lorusso, Mattia Andreotti, Leo Massari
BACKGROUND: The treatment of periprosthetic femoral fractures is a great challenge for the orthopedic surgeon and requires a knowledge of bone fracture fixation as well as skills and experience in revision surgery. The aim of this retrospective study was to evaluate the functional and radiological outcomes of periprosthetic femoral fractures surgically treated in our department from 2010 to 2016. MATERIALS AND METHODS: This study involved 73 patients with a periprosthetic femoral fracture after total hip arthroplasty or hemiarthroplasty...
November 25, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29153634/mid-term-survivals-after-cementless-bipolar-hemiarthroplasty-for-unstable-intertrochanteric-fractures-in-elderly-patients
#6
Jung-Taek Kim, Hyun-Ho Kim, Jae-Hyung Kim, Yoon-Ho Kwak, Eui-Chan Chang, Yong-Chan Ha
BACKGROUND: Treatment of unstable intertrochanteric fracture in elderly patients remains challenging. The purpose of this prospective study is to determine clinical and radiological results of cementless bipolar hemiarthroplasty using a fully porous-coated stem in osteoporotic elderly patients with unstable intertrochanteric fractures with follow-up over 5 years. METHODS: From January 2010 to December 2011, we performed 123 cementless bipolar hemiarthroplasties using fully porous-coated stem to treat unstable intertrochanteric fractures in elderly patients with osteoporosis...
November 16, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29130485/sophocarpine-attenuates-wear-particle-induced-implant-loosening-by-inhibiting-osteoclastogenesis-and-bone-resorption-via-suppression-of-the-nf-%C3%AE%C2%BAb-signaling-pathway-in-a-rat-model
#7
Chen-He Zhou, Zhong-Li Shi, Jia-Hong Meng, Bin Hu, Chen-Chen Zhao, Yu-Te Yang, Wei Yu, Ze-Xin Chen, Boon Chin Heng, Virginia-Jeni Akila Parkman, Shuai Jiang, Han-Xiao Zhu, Hao-Bo Wu, Wei-Liang Shen, Shi-Gui Yan
BACKGROUND AND PURPOSE: Aseptic prosthesis loosening, caused by wear particles, is one of the most common causes of arthroplasty failure. Extensive and over-activated osteoclast formation and physiological functioning are regarded as the mechanism of prosthesis loosening. Therapeutic modalities based on inhibiting osteoclast formation and bone resorption have been confirmed to be an effective way of preventing aseptic prosthesis loosening. In this study, we have investigated the effects of sophocarpine (SPC, derived from Sophora flavescens) on preventing implant loosening and further explored the underlying mechanisms...
November 11, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29109884/natural-remission-of-major-periprosthetic-osteolysis-following-total-hip-arthroplasty-with-metal-on-metal-bearings
#8
Tatsuya Tamaki, Kazuhiro Oinuma
The natural course of adverse events following the use of metal-on-metal (MoM) bearings in total hip arthroplasty (THA) is not well known. In this article, we report the case of a patient with asymptomatic major acetabular osteolysis following MoM THA that diminished gradually without any surgical intervention. A 58-year-old male underwent one-stage bilateral MoM THA for bilateral osteoarthritis. Four years after THA, major acetabular osteolysis developed in his right hip without any local or systemic symptoms...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29104084/orthopaedic-implant-materials-drive-m1-macrophage-polarization-in-a-spleen-tyrosine-kinase-and-mitogen-activated-protein-kinase-dependent-manner
#9
Olwyn R Mahon, Sarah O'Hanlon, Clare C Cunningham, Geraldine M McCarthy, Christopher Hobbs, Valeria Nicolosi, Daniel J Kelly, Aisling Dunne
Total joint replacements (TJR) are costly procedures required to relieve pain and restore function in patients suffering from end-stage arthritis. Despite great progress in the development and durability of TJRs, the generation of prosthesis-associated wear particles over time leads to an inflammatory cascade which culminates in periprosthetic osteolysis. Studies suggest that wear particles drive the polarization/differentiation of immature macrophages towards a pro-inflammatory M1 phenotype rather than an anti-inflammatory M2 phenotype associated with normal bone and wound healing...
November 2, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29101982/acr-appropriateness-criteria%C3%A2-imaging-after%C3%A2-total%C3%A2-knee-arthroplasty
#10
Mary G Hochman, Yulia V Melenevsky, Darlene F Metter, Catherine C Roberts, Jenny T Bencardino, R Carter Cassidy, Michael G Fox, Mark J Kransdorf, Douglas N Mintz, Nehal A Shah, Kirstin M Small, Stacy E Smith, Kathy M Tynus, Barbara N Weissman
Total knee arthroplasty (TKA) is the most commonly performed joint replacement procedure in the United States and annual demand for primary TKA is expected to grow by 673% by 2030. The first part provides an overview of imaging modalities (radiographs, CT, MRI, ultrasound, and various nuclear medicine studies) and discusses their usefulness in the imaging evaluation of TKA. The second part focuses on evidence-based imaging and imaging-guided intervention algorithms for the workup of TKA and its complications, including routine follow-up, component wear, periprosthetic infection, aseptic loosening, granulomas/osteolysis, conventional and rotational instability, periprosthetic fracture, patellar complications, and a variety of periprosthetic soft tissue abnormalities...
November 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29058079/extended-trochanteric-osteotomy-eto-fixation-for-femoral-stem-revision-in-periprosthetic-fractures-dall-miles-plate-versus-cables
#11
Gerard A Sheridan, Adam Galbraith, Stephen R Kearns, William Curtin, Colin G Murphy
BACKGROUND: Extended trochanteric osteotomy (ETO) is a well-established surgical technique used for femoral stem retrieval in revision hip arthroplasty procedures. Fixation of ETO is commonly achieved through wire, cable or cable-plate fixation. No evidence exists to date to suggest which method is superior when used in an acute traumatic setting. METHODS: Thirty cases of acute periprosthetic fracture requiring femoral stem revision with an ETO were identified over a 10-year period...
October 20, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28990090/calcineurin-nfat-signaling-pathway-mediates-titanium-particle%C3%A2-induced-inflammation-and-osteoclast-formation-by-inhibiting-rankl-and-m%C3%A2-csf-in%C3%A2-vitro
#12
Yunge Zhang, Peng Jiang, Wenbo Li, Xiangjie Liu, Yang Lu, Zhipeng Huang, Keguan Song
Wear particles serve a central role in periprosthetic osteolysis, which leads to the aseptic loosening of prostheses. In the present study a lentiviral vector was constructed to silence macrophage colony stimulating factor (M‑CSF) and receptor activator of nuclear factor κ‑B ligand (RANKL) genes, which synergistically inhibit osteoclast formation and differentiation. To confirm the role of the calcineurin/nuclear factor of activated T cells (NFAT) pathway in osteolysis, we transduced murine macrophage/monocyte RAW264...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28983216/ceramic-bearings-with-titanium-adapter-sleeves-implanted-during-revision-hip-arthroplasty-show-minimal-fretting-or-corrosion-a-retrieval-analysis
#13
Chelsea N Koch, Mark Figgie, Mark P Figgie, Marcella E Elpers, Timothy M Wright, Douglas E Padgett
BACKGROUND: The BIOLOX® option system, consisting of a BIOLOX® delta ceramic femoral head with a titanium alloy adapter sleeve, is being increasingly utilized in revision hip arthroplasty. The sleeve protects the ceramic head from fracture and improper motion about the stem trunnion when a damaged trunnion is encountered at revision surgery. Corrosion and fretting due to metal-metal contact at the taper region of hip prosthesis create the potential of causing periprosthetic osteolysis and adverse local tissue reactions...
October 2017: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/28978284/murine-model-of-progressive-orthopaedic-wear-particle-induced-chronic-inflammation-and-osteolysis
#14
Jukka Pajarinen, Akira Nabeshima, Tzu-Hua Lin, Taishi Sato, Emmanuel Gibon, Eemeli Jämsen, Laura Lu, Karthik Nathan, Zhenyu Yao, Stuart B Goodman
Periprosthetic osteolysis and subsequent aseptic loosening of total joint replacements are driven by byproducts of wear released from the implant. Wear particles cause macrophage mediated inflammation that culminates with periprosthetic bone loss. Most current animal models of particle- induced osteolysis are based on the acute inflammatory reaction induced by wear debris, which is distinct from the slowly progressive clinical scenario. To address this limitation we previously developed a murine model of periprosthetic osteolysis that is based on slow continuous delivery of wear particles into the murine distal femur over a period of 4 weeks...
October 5, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28883822/the-role-of-the-chemokine-system-in-tissue-response-to-prosthetic-by-products-leading-to-periprosthetic-osteolysis-and-aseptic-loosening
#15
REVIEW
Tereza Dyskova, Jiri Gallo, Eva Kriegova
Millions of total joint replacements are performed annually worldwide, and the number is increasing every year. The overall proportion of patients achieving a successful outcome is about 80-90% in a 10-20-years time horizon postoperatively, periprosthetic osteolysis (PPOL) and aseptic loosening (AL) being the most frequent reasons for knee and hip implant failure and reoperations. The chemokine system (chemokine receptors and chemokines) is crucially involved in the inflammatory and osteolytic processes leading to PPOL/AL...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28808626/acetabular-revisions-using-porous-tantalum-components-a-retrospective-study-with-5-10-years-follow-up
#16
Francesco Roberto Evola, Luciano Costarella, Giuseppe Evola, Martina Barchitta, Antonella Agodi, Giuseppe Sessa
AIM: To evaluate the clinical and X-ray results of acetabular components and tantalum augments in prosthetic hip revisions. METHODS: Fifty-eight hip prostheses with primary failure of the acetabular component were reviewed with tantalum implants. The clinical records and X-rays of these cases were retrospectively reviewed. Bone defect evaluations were based on preoperative CT scans and classified according to Paprosky criteria of Radiolucent lines and periprosthetic gaps; implant mobilization and osteolysis were evaluated by X-ray...
July 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28795083/mechanical-instability-and-titanium-particles-induce-similar-transcriptomic-changes-in-a-rat-model-for-periprosthetic-osteolysis-and-aseptic-loosening
#17
Mehdi Amirhosseini, Göran Andersson, Per Aspenberg, Anna Fahlgren
Wear debris particles released from prosthetic bearing surfaces and mechanical instability of implants are two main causes of periprosthetic osteolysis. While particle-induced loosening has been studied extensively, mechanisms through which mechanical factors lead to implant loosening have been less investigated. This study compares the transcriptional profiles associated with osteolysis in a rat model for aseptic loosening, induced by either mechanical instability or titanium particles. Rats were exposed to mechanical instability or titanium particles...
December 2017: Bone Reports
https://www.readbyqxmd.com/read/28782280/orthopaedic-wear-particle-induced-bone-loss-and-exogenous-macrophage-infiltration-is-mitigated-by-local-infusion-of-nf-%C3%AE%C2%BAb-decoy-oligodeoxynucleotide
#18
Tzuhua Lin, Jukka Pajarinen, Akira Nabeshima, Luis A Córdova, Florence Loi, Emmanuel Gibon, Laura Lu, Karthik Nathan, Eemeli Jämsen, Zhenyu Yao, Stuart B Goodman
Excessive production of wear particles from total joint replacements induces chronic inflammation, macrophage infiltration, and consequent bone loss (periprosthetic osteolysis). This inflammation and bone remodeling are critically regulated by the transcription factor NF-κB. We previously demonstrated that inhibition of NF-κB signaling by using the decoy oligodeoxynucleotide (ODN) mitigates polyethylene wear particle-induced bone loss using in vitro and in vivo models. However, the mechanisms of NF-κB decoy ODN action, and in particular its impact on systemic macrophage recruitment, remain unknown...
August 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28773099/the-impact-of-metal-ion-exposure-on-the-cellular-behavior-of-human-osteoblasts-and-pbmcs-in-vitro-analyses-of-osteolytic-processes
#19
Anika Jonitz-Heincke, Jenny Tillmann, Annett Klinder, Simone Krueger, Jan Philippe Kretzer, Paul Johan Høl, Alexander C Paulus, Rainer Bader
Osteolysis in the periprosthetic tissue can be caused by metallic wear particles and ions that can originate from implant surface corrosion. These products influence cellular behavior and stimulate the expression of proinflammatory cytokines. The purpose of this study was to evaluate the impact of CoCr29Mo6 ions on cell survival, differentiation, and cytokine expression in human osteoblasts and peripheral blood mononuclear cells (PBMCs). Thus, we exposed cells with a mixture of 200 µg/L ion solution and determined cell viability and apoptosis/necrosis...
July 3, 2017: Materials
https://www.readbyqxmd.com/read/28760844/inhibitory-effect-ofquercetinon-titaniumparticle-inducedendoplasmic-reticulum-stress-ers-related-apoptosisandin-vivoosteolysis
#20
Laibo Zhang, Zhoubin Tian, Wei Li, Xianquan Wang, Zhentao Man, Shui Sun
Wear particle-induced periprosthetic osteolysis is the main cause of aseptic loosening of orthopaedic implants. The aim of this study is to determine the protective effect of quercetin (QUE) against titanium (Ti) particle-induced ERS-related apoptosis and osteolysis. In this study, RAW264.7 cells were pretreated with different concentrations (40, 80, and 160 μmol/l) of QUE for 30 min and then treated with Ti particle (5 mg/ml) for 24 h. Cell viability and apoptosis were determined using MTT assay and Annexin V-FITC apoptosis detection kit, respectively...
July 31, 2017: Bioscience Reports
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