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overdose bcg

Ali Abdullah Al-Maqbali, Amal Saif Suliman Al-Maani
A two-day-old male neonate was inadvertently immunized with 20-times the recommended dose of Bacillus Calmette-Guérin (BCG) vaccine (1.0 ml instead of 0.05 ml). Examination of the neonate after one day revealed no signs of local reaction at the site of injection or systemic manifestation. However, nine days later, he developed a swelling (4 × 3 cm) at the site of injection without any enlargement of the lymph node, pallor, or jaundice. A needle aspiration of the swelling was done and sent for culture. The culture showed the BCG strain only...
July 2016: Oman Medical Journal
Güniz Yaşöz, Nurşen Belet, Gülnar Şensoy
The Bacille Calmette-Guérin (BCG) vaccine is used against tuberculosis. According to the vaccination program in Turkey, DaBT-Hib-IPV (diphtheriapertussis [acellular]-tetanus-haemophilus influenza type b-inactive poliovaccine), PVC13 (pneumoccocal conjugate vaccine) and BCG vaccines are given simultaneously to all 2-months-old infants, using different administration techniques. We report a 2-month-old infant who received an overdose and intramuscular BCG vaccine instead of DaBT-Hib-IPV. The patient was treated with isoniazid for six months and developed no complications during a oneyear follow-up period...
November 2014: Turkish Journal of Pediatrics
Nicole Ritz, Marc Tebruegge, Jonathan Streeton, Nigel Curtis
A 14-year-old girl was inadvertently immunised with an excessively large dose of BCG-Connaught vaccine (1.0 ml instead of 0.1 ml). Examination of the patient a few hours later revealed a subcutaneous fluctuant tender lump at the injection site. This was surgically excised within 12h of immunisation and she was treated with isoniazid and rifampicin for six weeks. The patient developed no complications, other than a minor surgical scar. This case highlights the importance of the correct administration and dosing of BCG vaccine and suggests a management option that may prevent the severe local and systemic complications that are frequently associated with BCG overdose...
September 18, 2009: Vaccine
Xiang-Hua Lin, Inseon S Choi, Young-Ah Koh, Yong Cui
Both bacille Calmette-Guerin (BCG) and dehydroepiandrosterone induce Th1 immune responses and suppress Th2 allergic reactions. To investigate whether a combined administration of BCG and dehydroepiandrosterone treat asthma more effectively, BALB/c mice (n = 8 per group) with established airway hyper-responsiveness were treated with BCG and/or dehydroepiandrosterone. Combined treatment with 2 x 10(5) colony-forming units (CFUs) of BCG and 0.01% dehydroepiandrosterone was the most effective one at suppressing eosinophilia in bronchoalveolar lavage fluids...
April 2009: Experimental Lung Research
Yong Cui, Inseon S Choi, Young-Ah Koh, Xiang-Hua Lin, Yong-Bum Cho, Young-Ho Won
Both BCG and dehydroepiandrosterone (DHEA) induce Th1 immune responses and suppress Th2 allergic reactions. To investigate whether the combination of BCG and DHEA has an additive effect on asthma prevention, BALB/c mice (n = 10 per group) were given an intraperitoneal injection of BCG at the beginning of sensitization, and fed mice chow containing DHEA throughout the study. In female mice, the combined administration of 2 x 10(4) CFUs BCG and 0.01% DHEA effectively suppressed the ovalbumin-induced increase in airway sensitivity to methacholine (56...
2008: Immunological Investigations
H El Ouazzani, H Lamsyah, Z Alioua, I Rhorfi, M Rguibi, M Ghfir, A Abid, O Sedrati, K Alaoui-Tahiri
INTRODUCTION: Calmette-Guérin bacillus (BCG) is a live attenuated strain used in tuberculosis vaccination. Local and systemic side-effects, although rare, are associated with BCG vaccine. They are common in cases of overdose and with poor vaccination techniques. These complications also occur in some cases of revaccination. PATIENTS AND METHODS: This was a retrospective study over a period of 5 years between January 2000 and March 2005. 12 patients presenting complications following revaccination with BCG were observed...
February 2007: Annales de Dermatologie et de Vénéréologie
(no author information available yet)
(1) The 22nd French pharmacovigilance meeting, held in July 2001, presented data on adverse effects notified by health professionals to regional pharmacovigilance centres in France. (2) Non specific "immunostimulants" are not harmless placebos, as might be concluded from the relative lack of data. There have been 315 notifications of severe adverse effects, some with positive rechallenge, reporting cutaneous, gastrointestinal, respiratory, haematological and other disorders. Attributability was considered "likely" in 68% of cases...
February 2002: Prescrire International
F Benamar, E Loupi
The inappropriate use of BCG vaccine could be followed by adverse events (AE). In order to know their frequency and type, we evaluated the spontaneous reports of misuses (MS) and overdosages (OV) over a 4-year period. One hundred and twenty-six notifications were collected; 109 concerned MS, 13 OV, and 4 concerned both MS and OV. We recorded a high number (97) of MS related to the injection of a BCG vaccine instead of a tuberculin test (TT). Among the 126 initial notifications, 122 cases of AE were reported, 107 after an MS, 11 after an OV and 4 after both MS and OV...
November 2001: Thérapie
J M Grange
Complications of bacille Calmette-Guérin (BCG) vaccination are uncommon. Fewer than one in 1000 people vaccinated develop significant local reactions, and serious disseminated disease develops in fewer than one in a million. Localised complications--which include hypersensitivity reactions, abscesses at the injection site, and localised lymphadenopathy--are usually self limiting. They usually result from faulty technique, including the accidental intracutaneous injection of the stronger percutaneous vaccine, or poor selection of subjects for vaccination...
June 1998: Communicable Disease and Public Health
J M Puliyel, A Hughes, M L Chiswick, M Z Mughal
No abstract text is available yet for this article.
August 31, 1996: BMJ: British Medical Journal
Z Katzir, E Okon, A Ludmirski, Y Sherman, H Haas
An immunocompetent, healthy 12-year-old boy was presented with generalized large lymphadenopathy in the left side of the body, 1 month after a BCG vaccination with a regular dose. A Mantoux test before vaccination was negative. Histological and bacteriological findings from the largest lymph node biopsy revealed BCG'itis. The patient recovered spontaneously after 7 months. He was confirmed as being immunocompetent by normal serum immunoglobulin levels, normal B and T cell function tests, and a conversion of Mantoux test...
January 1984: European Journal of Pediatrics
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