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https://www.readbyqxmd.com/read/28550399/addition-of-second-line-steroid-sparing-immunosuppressants-like-mycophenolate-mofetil-improves-outcome-of-immunoglobulin-g4-related-disease-igg4-rd-a-series-from-a-tertiary-care-teaching-hospital-in-south-india
#1
Nikhil Gupta, John Mathew, Hindhumathi Mohan, Sudipta Dhar Chowdhury, Reuben Thomas Kurien, D J Christopher, Balamugesh Thangakunam, Mathew Alexander, Ajith Sivadasan, V Tamilarasi, Anna T Valson, Mahasampath Gowri, Jayakanthan Kabeerdoss, Debashish Danda
IgG4-related disease (IgG4-RD) is a systemic fibro-inflammatory disease. This disease may be associated with elevated serum and tissue IgG4 levels. Early treatment prevents fibrosis and organ damage. We retrospectively studied the clinicopathologic correlation and outcome of treatment in IgG4-RD. This single-center retrospective study was done using electronic records of patients subjected to assay of serum IgG4 levels in our laboratory by nephelometry. There were 473 patients with suspected IgG4-RD. Of them, 41 patients fulfilled comprehensive diagnostic criteria for IgG4-RD and 432 had diseases other than IgG4-RD...
May 26, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28543806/effect-of-microthreads-on-coronal-bone-healing-of-narrow-diameter-implants-with-reverse-tapered-design-in-beagle-dogs
#2
Yun-Young Chang, Su-Hwan Kim, Keun-Oh Park, Jeong-Ho Yun
OBJECTIVES: The objective of this study was to investigate the effect of microthreads on the coronal bone healing of narrow-diameter implants with reverse-tapered design. MATERIAL AND METHODS: A total of 52 implants were classified into two groups according to presence or absence of coronal microthreads, the reverse-tapered narrow-diameter implant (RTN) group, and the reverse-tapered narrow-diameter implant with microthreads (RTNM) group. The implants were installed in split-mouth design in the edentulous mandible of six dogs...
May 22, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/28542904/can-resonance-frequency-analysis-rfa-detect-narrow-marginal-bone-defects-around-dental-implants-an-ex-vivo-animal-pilot-study
#3
Coral Jie Yao, Li Ma, Nikos Mattheos
BACKGROUND: Resonance Frequency Analysis (RFA) is widely applied to assess implant stability, as expressed by Implant Stability Quotient (ISQ). However, the relation between ISQ value and the presence and extent of narrow marginal bone defects around implants has not been documented. PURPOSE: To investigate the potential of RFA devices to identify the presence and extent of marginal bone defects around implants, as expressed by the ISQ values. MATERIALS AND METHODS: 28 Straumann bone level implants (BL) and 28 bone level tapered implants (BLT), were placed ex-vivo in porcine ribs...
May 25, 2017: Australian Dental Journal
https://www.readbyqxmd.com/read/28542042/comparison-between-cortical-drill-and-cortical-tap-and-their-influence-on-primary-stability-of-macro-thread-tapered-implant-in-thin-crestal-cortical-bone-and-low-density-bone
#4
Dasom Heo, Young-Ku Heo, Jong-Ho Lee, Jun-Jae Lee, Bongju Kim
OBJECTIVE: To evaluate the effect of different surgical techniques on primary stability, particularly in poor-quality bone with or without a crestal cortical bone. MATERIALS AND METHODS: Three implant site preparation techniques-undersized drilling (UD), undersized drilling and coronal widening with a cortical drill (UD + CD), undersized drilling and coronal tapping with a cortical tap (UD + CT)-were compared in 2 different low-density polyurethane bone models either with or without the crestal cortical bone...
May 23, 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28540607/treatment-response-to-etanercept-in-methotrexate-refractory-juvenile-idiopathic-arthritis-an-analysis-of-predictors-and-long-term-outcomes
#5
Yueh Su, Yao-Hsu Yang, Bor-Luen Chiang
The aim of the study is to evaluate the long-term outcomes, predictors, and the role of inflammatory cytokines in methotrexate (MTx) refractory juvenile idiopathic arthritis (JIA) patients. This is a retrospective cohort study. MTx refractory JIA patients who received etanercept as their first biological agent in National Taiwan University Hospital (NTUH) were enrolled. Patients were classified into remission group, non-remission group, relapsing group, and non-relapsing group according to the criteria of disease remission and disease flares defined by Wallace et al...
May 24, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28539536/remission-induction-therapy-with-rituximab-for-microscopic-polyangiitis-a-feasibility-study
#6
Ayako Saito, Yoichi Takeuchi, Saeko Kagaya, Yoshie Ojima, Hirotaka Fukami, Hiroyuki Sato, Ken Matsuda, Tasuku Nagasawa
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is systemic vascular inflammation. Microscopic polyangiitis (MPA) is a major type of AAV in Japan. MPA often affects the kidneys and lungs, leading to death if untreated. Induction therapy (i.e., initial treatment) for MPA has not been optimized, although methylprednisolone and cyclophosphamide are commonly used. Recently, rituximab (RTX) (a monoclonal antibody against the protein CD20) has also been used to treat refractory AAV. RTX at 375 mg/m(2)/week for 4 weeks (i...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28539146/keratoconus-in-civil-aviation-pilots-in-a-report-of-six-cases
#7
Albert Rebello, Bênesson Rodrigues, Marcos Pereira
BACKGROUND: Keratoconus is a progressive noninflammatory ectatic corneal dystrophy, characterized by corneal thinning and increased curvature with central or paracentral tapered protrusion. Such changes in corneal morphology induce irregular astigmatism and myopia, resulting in visual acuity impairment. This report assesses cases in which keratoconus is not an absolute disabling condition for civil aviation pilots. METHODS: Six cases of keratoconus in active pilots are presented...
June 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28536229/cyclooxygenase-2-inhibitor-induced-acute-interstitial-nephritis
#8
Brittany Albrecht, Shelley Giebel, Michelle McCarron, Bhanu Prasad
A 64-year-old female patient presented to the emergency department with a 3-week history of persistent nausea and vomiting. Her serum creatine prior to admission was 118 µmol/L and on presentation was elevated to 420 µmol/L. On clinical history, she indicated that 3 weeks prior, she had been initiated on a cyclooygenase-2 (COX-2) inhibitor, celecoxib, for her osteoarthritis of her knees. Renal biopsy confirmed the diagnosis of acute interstitial nephritis (AIN). Celecoxib was discontinued and the patient's renal function improved to a discharge creatine of 205-220 µmol/L...
May 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28535241/management-of-depression-in-older-adults-a-review
#9
Rob M Kok, Charles F Reynolds
Importance: Depression in older adults is a common psychiatric disorder affecting their health-related quality of life. Major depression occurs in 2% of adults aged 55 years or older, and its prevalence rises with increasing age. In addition, 10% to 15% of older adults have clinically significant depressive symptoms, even in the absence of major depression. Observations: Depression presents with the same symptoms in older adults as it does in younger populations...
May 23, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28535033/correction-to-fabrication-of-tapered-microtube-arrays-and-their-application-as-a-microalgal-injection-platform
#10
Andrew R Durney, Leah C Frenette, Elizabeth C Hodvedt, Todd D Krauss, Hitomi Mukaibo
No abstract text is available yet for this article.
May 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28533998/ipilimumab-as-a-cause-of-severe-pan-colitis-and-colonic-perforation
#11
Raj Shah, Danielle Witt, Talal Asif, Fahad F Mir
Ipilimumab is a human monoclonal antibody that functions as a cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) inhibitor that is used to treat malignant melanoma. Due to ipilimumab's removal of immune regulation, specifically through the inactivation of CTLA-4, it is commonly associated with inflammatory and autoimmune events. Gastrointestinal (GI) related immune-related adverse events such as diarrhea occur in 29% of patients with 7.6% of patients specifically suffering from colitis. We describe a case of colonic perforation with ipilimumab use...
April 20, 2017: Curēus
https://www.readbyqxmd.com/read/28532041/comparative-analysis-of-stress-in-a-new-proposal-of-dental-implants
#12
Mariana Lima da Costa Valente, Denise Tornavoi de Castro, Ana Paula Macedo, Antonio Carlos Shimano, Andréa Cândido Dos Reis
The purpose of this study was to compare, through photoelastic analysis, the stress distribution around conventional and modified external hexagon (EH) and morse taper (MT) dental implant connections. Four photoelastic models were prepared (n=1): Model 1 - conventional EH cylindrical implant (Ø 4.0mm×11mm - Neodent®), Model 2 - modified EH cylindrical implant, Model 3 - conventional MT Conical implant (Ø 4.3mm×10mm - Neodent®) and Model 4 - modified MT conical implant. 100 and 150N axial and oblique loads (30° tilt) were applied in the devices coupled to the implants...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28530474/optimising-pre-season-training-loads-in-australian-football
#13
David L Carey, Justin Crow, Kok-Leong Ong, Peter Blanch, Meg E Morris, Ben J Dascombe, Kay M Crossley
PURPOSE: To investigate whether pre-season training plans for Australian football can be computer generated using current training load guidelines to optimise injury risk reduction and performance improvement. METHODS: A constrained optimisation problem was defined for daily total and sprint distance, using the pre-season schedule of an elite Australian football team as a template. Maximising total training volume and maximising Banister model projected performance were both considered as optimisation objectives...
May 22, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28528891/salivary-steroids-hormones-well-being-and-physical-performance-during-an-intensification-training-period-followed-by-a-tapering-period-in-youth-rhythmic-gymnasts
#14
Kizzy Antualpa, Marcelo Saldanha Aoki, Alexandre Moreira
This study examined the effect of an intensification period (IT; 4weeks; after a habitual training period; HT) followed by a tapering period (TP; 2weeks) on salivary hormones (testosterone - T and cortisol - C), well-being (WB), and physical performance in 23 rhythmic gymnasts (RG; Under-11 group [G1], Under-13 group [G2], and >13 group [G3]). The session-rating of perceived exertion was used to quantify the daily internal training load (ITL). The WB questionnaire was completed daily. Physical performance tests and saliva sampling were carried out at the beginning of the IT (T1), after IT (T2), and after TP (T3)...
May 18, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28528436/the-unresolved-riddle-of-glucocorticoid-withdrawal
#15
REVIEW
F Guerrero Pérez, A P Marengo, C Villabona Artero
Glucocorticoid (GC) therapy is the most common cause of adrenal insufficiency (AI). The real prevalence of AI after GC is unknown but it could involve more than 30% of patients. Some gene variation has been associated with the variability of hypothalamic-pituitary-adrenal (HPA) axis and this issue could contribute to the individual variation of adrenal function after GC treatment. Symptoms and signs of AI are nonspecific and frequently the diagnosis is delayed. Dosage, duration of treatment, administration route and serum cortisol value are not completely useful to predict AI...
May 20, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28522242/monitoring-the-surface-quality-of-silver-plasmon-waveguides-with-nonlinear-photoemission-electron-microscopy-and-in-situ-ion-sputtering
#16
Kellie Pearce, Francis Schuknecht, Christian Späth, Benjamin Duschner, Florian Richter, Ulf Kleineberg
We use photoemission electron microscopy (PEEM) with single- and two-photon excitation to study the properties of surface plasmon polaritons (SPPs) in tapered silver stripe waveguides. Arrays of waveguides with different widths, grating coupler geometries, and taper angles are fabricated using electron beam lithography (EBL) on Si and indium-tin-oxide (ITO)-covered glass substrates. The presence of propagating SPP modes is indicated by modulations of the non-linear photoemission intensity which run along the length of the waveguide - the result of interfering SPPs reflected from the edges...
May 10, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28521113/real-time-imaging-of-gap-progress-during-and-after-composite-polymerization
#17
J Hayashi, Y Shimada, J Tagami, Y Sumi, A Sadr
The aims of this study were to observe the behavior of composite and formation of gaps during and immediately after light polymerization using swept source optical coherence tomography (OCT) and to compare the interfacial integrity of adhesives in cavities through 3-dimensional (3D) image analysis. Forty tapered cylindrical cavities (4-mm diameter, 2-mm depth) were prepared in bovine incisors and restored using Bond Force (BF), Scotchbond Universal Adhesive (SBU), OptiBond XTR (XTR), or Clearfil SE Bond 2 (SE2), followed by Estelite Flow Quick flowable composite...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28520586/clinical-course-of-ulcerative-colitis-after-liver-transplantation-in-patients-with-concomitant-primary-sclerosing-cholangitis-and-ulcerative-colitis
#18
Mohammad Reza Fattahi, Seyyed Ali Malek-Hosseini, Gholam Reza Sivandzadeh, Ali Reza Safarpour, Kamran Bagheri Lankarani, Ali Reza Taghavi, Fardad Ejtehadi
BACKGROUND: The natural history of ulcerative colitis (UC) after liver transplantation (LT) for primary sclerosing cholangitis (PSC) remains ill defined. This study aimed to evaluate the course of UC after LT for PSC. METHODS: The course of UC, including the clinical colitis severity index, was evaluated in patients with concomitant PSC and UC who received LT for PSC-induced end-stage liver disease. A total of 167 (55.4%) patients with PSC had concurrent inflammatory bowel disease (IBD)...
May 16, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28520452/-relapsing-autoimmune-pancreatitis-type-1-case-report
#19
Alena Ondrejková, Bohuslav Kianička, Hana Nechutová, Lukáš Hruška, Ivo Novotný, Miroslav Souček
Autoimmune pancreatitis (AIP) is a rare form of chronic pancreatitis, classified into 2 subtypes - AIP type 1 and AIP type 2. We present a case of a 31-years-old female admitted to our institution with upper abdominal pain and obstructive jaundice. Endoscopic retrograde cholangiopancreatoscopy (ERCP) revealed stenosis of intrapancreatic distal bile duct. Diffuse parenchymal enlargement and typical features of AIP were shown by computed tomography (CT) and endoscopic ultrasonography (EUS). The patient´s serum IgG4 was elevated at 3...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28518184/a-method-for-minimizing-rotational-errors-of-implant-prostheses
#20
Hyeonjong Lee, Kung-Rock Kwon, Janghyun Paek, Ahran Pae, Kwantae Noh
PURPOSE: Rotational errors of implants can occur during two stages: when connecting impression copings with implants, and when connecting impression copings with analogs. The aim of this study was to determine ways to minimize these rotational errors. MATERIALS AND METHODS: Three types of implants were prepared: a tissue-level implant with an internal octagon 8-degree Morse taper connection, a bone-level implant with an internal hex 11-degree Morse taper connection, and a bone-level implant with an external hex connection...
May 18, 2017: International Journal of Oral & Maxillofacial Implants
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