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https://www.readbyqxmd.com/read/29793012/endovascular-repair-of-a-penetrating-aortic-ulcer-with-a-custom-made-relay-stent-graft-featuring-a-single-celiac-trunk-fenestration-and-a-superior-mesenteric-artery-scallop
#1
G Natalicchio, A Biello, G Castriotta, M G C La Marca, G Sorino, M Salcuni
We report the case of a 70-year-old man with an asymptomatic, fast-growing, paraceliac penetrating aortic ulcer (PAU). Guidelines recommend endovascular repair if an asymptomatic PAU shows a mean growth rate ≥5 mm per year: this patient's maximum aortic diameter was 47 mm but had increased 10 mm in the previous year. The very short sealing zones required a custom-made stent-graft. A custom-made Relay stent-graft with a single celiac trunk fenestration, a superior mesenteric artery (SMA) scallop measured according to SMA ostium size, an uncovered distal stent, and 6-mm tapering was used with technical and clinical success...
May 21, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29791373/broadband-te-pass-slot-waveguide-polarizer-using-an-asymmetrical-directional-coupler
#2
Bin Ni, Jinbiao Xiao
A compact TE-pass polarizer for silicon-based slot waveguides is numerically proposed based on a directional coupler where an asymmetrical slot waveguide (ASW) and hybrid plasmonic waveguide (HPW) are involved. The input section is linearly tapered to an ASW to markedly enlarge the modal birefringence. Beneficially, only the TM mode can be coupled into the adjacent HPW and attenuated while the injected TE mode just passes through the slot waveguide without coupling by properly choosing the dimensions. As a consequence, an efficient TE-pass polarizer can be implemented...
May 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29790664/the-dynamics-of-a-healthy-and-infected-red-blood-cell-in-flow-through-constricted-channels-a-dpd-simulation
#3
Sazid Zamal Hoque, D V Anand, B S V Patnaik
Understanding the dynamics of red blood cell (RBC) motion under in-silico conditions is central to the development of cost effective diagnostic tools. Specifically, unraveling the relationship between the rheological properties and the nature of shape change in the RBC (healthy or infected) can be extremely useful. In case of malarial infection, RBC progressively loses its deformability and tends to occlude the microvessel. In the present study, detailed mesoscopic simulations are performed to investigate the deformation dynamics of a RBC in flow through a constricted channel...
May 23, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29785993/factors-predicting-response-of-pseudophakic-cystoid-macular-edema-to-topical-steroids-and-nepafenac
#4
Sabyasachi Sengupta, Dhaivat Vasavada, Utsab Pan, Manavi Sindal
Purpose: The purpose of this study is to determine factors predicting resolution of acute pseudophakic cystoid macular edema (PCME) after 6 weeks of topical prednisolone and nepafenac application. Methods: Case records of patients with a clinical and optical coherence tomography (OCT)-based diagnosis of acute PCME were retrospectively reviewed for best-corrected visual acuity and OCT-based parameters at the time of presentation with PCME. In addition, demographic variables, intraoperative and early postoperative factors, and type of treatment prescribed (tapering vs...
June 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29784469/duration-of-post-vaccination-immunity-to-yellow-fever-in-volunteers-eight-years-after-a-dose-response-study
#5
Reinaldo de Menezes Martins, Maria de Lourdes S Maia, Sheila Maria Barbosa de Lima, Tatiana Guimarães de Noronha, Janaina Reis Xavier, Luiz Antonio Bastos Camacho, Elizabeth Maciel de Albuquerque, Roberto Henrique Guedes Farias, Thalita da Matta de Castro, Akira Homma
In 2009, Bio-Manguinhos conducted a dose-response study with the yellow fever vaccine, administering the vaccine in the usual mean dose of 27,476 IU (full dose, reference) and in tapered doses (10,447 IU, 3013 IU, 587 IU, 158 IU, and 31 IU) by the usual subcutaneous route and usual volume (0.5 mL). Tapered doses were obtained by dilution in the manufacturer's laboratory, and the test batches presented industrial quality. Doses down to 587 IU showed similar immunogenicity to the full dose (27,476, reference), while the 158 IU and 31 IU doses displayed lower immunogenicity...
May 18, 2018: Vaccine
https://www.readbyqxmd.com/read/29784057/incidence-of-hypotension-according-to-the-discontinuation-order-of-vasopressors-in-the-management-of-septic-shock-a-prospective-randomized-trial-dovss
#6
Kyeongman Jeon, Jae-Uk Song, Chi Ryang Chung, Jeong Hoon Yang, Gee Young Suh
BACKGROUND: Vasopressin (AVP) is commonly added to norepinephrine (NE) to reverse shock in patients with sepsis. However, there are no data to support the appropriate strategy of vasopressor tapering in patients on concomitant NE and AVP who are recovering from septic shock. Therefore, the objective of this study was to evaluate the incidence of hypotension while tapering vasopressors in patients on concomitant NE and AVP recovering from septic shock. METHODS: Patients with septic shock receiving concomitant NE and AVP were randomly assigned to taper NE first (NE group) or AVP first (AVP group)...
May 21, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29784018/adding-colchicine-to-immunosuppressive-treatments-a-potential-option-for-biologics-refractory-adult-onset-still-s-disease
#7
Tomoyuki Asano, Makiko Yashiro Furuya, Shuzo Sato, Hiroko Kobayashi, Hiroshi Watanabe, Eiji Suzuki, Kiyoshi Migita
BACKGROUND: Adult-onset Still's disease (AOSD) is a rare inflammatory disorder characterized by the classical triad of daily spiking fever, arthritis, and typical salmon-colored rash. Resistance to first-line corticosteroids and second-line disease modified anti-rheumatic-drugs defines refractory AOSD, which mostly includes the polycyclic or chronic courses of the disease. Anti-cytokine therapies are recommended in AOSD patients who are refractory to traditional treatments. This is the first report on the efficacy of colchicine in a patient with AOSD which was refractory to immunosuppressive treatments including biologics...
May 21, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29782303/clindamycin-induced-maculopapular-exanthema-with-preferential-involvement-of-striae-distensae-a-koebner-phenomenon
#8
Benigno Monteagudo, Miguel Cabanillas, Pilar Iriarte, Aquilina Ramírez-Santos, Elvira León-Muinos, Daniel González-Vilas, Óscar Suárez-Amor
Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). A 47-year-old woman was referred to our clinic for pruritic cutaneous lesions which had started 6 days earlier...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29782005/the-diffusion-of-passive-tracers-in-laminar-shear-flow
#9
Manuchehr Aminian, Francesca Bernardi, Roberto Camassa, Daniel M Harris, Richard M McLaughlin
A simple method to experimentally observe and measure the dispersion of a passive tracer in a laminar fluid flow is described. The method consists of first injecting fluorescent dye directly into a pipe filled with distilled water and allowing it to diffuse across the cross-section of the pipe to obtain a uniformly distributed initial condition. Following this period, the laminar flow is activated with a programmable syringe pump to observe the competition of advection and diffusion of the tracer through the pipe...
May 1, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29780948/adrenocorticotropic-hormone-analogue-as-novel-treatment-regimen-in-ocular-cicatricial-pemphigoid
#10
Yael Sharon, David S Chu
Purpose: To report the clinical outcome of a patient with ocular cicatricial pemphigoid, treated with adrenocorticotropic hormone gel. Observations: A 75-year-old female with a biopsy proven ocular cicatricial pemphigoid (OCP) presented with bilateral conjunctival inflammation, fornix shortening, subepithelial fibrosis and corneal scarring. The patient was previously treated with topical steroids, topical cyclosporine and lubricating drops, and had undergone several amniotic membrane transplants due to recurrent corneal erosions...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29780945/treatment-challenges-in-an-atypical-presentation-of-tubulointerstitial-nephritis-and-uveitis-tinu
#11
Sonny Caplash, Sapna Gangaputra, Shilpa Kodati, Shamir Tuchman, Hemalatha Srinivasalu, H Nida Sen
Purpose: To describe an atypical presentation of Tubulointerstitial Nephritis and Uveitis (TINU), with challenges in treatment course. Observations: A 12-year-old Hispanic female presented to the National Eye Institute's Uveitis clinic with bilateral blurred vision, red eyes and photophobia, not responsive to topical steroids. On exam, she had bilateral severe panuveitis with areas of subretinal fluid. During her evaluation, she was noted to have elevated serum creatinine...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29780921/is-it-melanoma-associated-retinopathy-or-drug-toxicity-bilateral-cystoid-macular-edema-posing-a-diagnostic-and-therapeutic-dilemma
#12
Sachi R Patel, Stavros N Moysidis, Nicole Koulisis, Philip P Storey, Amir H Kashani, Narsing A Rao, Damien C Rodger
Purpose: To report the clinical presentation, multimodal imaging, and management of a patient with metastatic melanoma who presented with cystoid macular edema (CME). Observations: We report a case of a 71-year-old Caucasian male with metastatic melanoma who presented with bilateral cystoid macular edema after being on treatment with a programmed T cell death ligand 1 inhibitor, MPDL3280, for 1 year. Multimodal imaging techniques, including color fundus photographs, autofluorescence, spectral domain optical coherence tomography (OCT), fluorescein angiography (Spectralis, Heidelberg, Germany), and spectral-domain OCT angiography (Zeiss; California, USA) were performed to evaluate the etiology of his CME and to monitor his response to treatment...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29780745/impact-of-minimal-root-canal-taper-on-the-fracture-resistance-of-endodontically-treated-bicuspids
#13
Carla Zogheib, Germain Sfeir, Gianluca Plotino, Gustavo De Deus, Maha Daou, Issam Khalil
Objective: Minimal invasive endodontics preserve coronal and radicular tooth structure to increase the fracture resistance of teeth. The aim of this study was to assess the influence of final preparation taper on the fracture resistance of maxillary premolars. Materials and Methods: Sixty maxillary premolars were selected and divided into 2 groups: 30 were shaped with a final apical diameter 30 and a 4% taper and 30 with 6% taper using iRaCe® instrument (FKG dentaire, Switzerland)...
March 2018: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29776658/ustekinumab-for-refractory-giant-cell-arteritis-a-prospective-52-week-trial
#14
Richard Conway, Lorraine O'Neill, Phil Gallagher, Geraldine M McCarthy, Conor C Murphy, Douglas J Veale, Ursula Fearon, Eamonn S Molloy
OBJECTIVES: Giant cell arteritis (GCA) is the most common form of systemic vasculitis. Glucocorticoids are an effective treatment but have significant adverse events and relapses are common. Interleukins 12 (IL-12) and 23 (IL-23) stimulate TH 1 and TH 17 responses and are implicated in the pathogenesis of GCA. The aim of this study was to evaluate the efficacy and safety of IL-12/23 blockade with ustekinumab in GCA. METHODS: We performed a prospective open label study of ustekinumab in patients with refractory GCA...
April 22, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29774135/vemurafenib-in-langerhans-cell-histiocytosis-report-of-a-pediatric-patient-and-review-of-the-literature
#15
Anne Heisig, Jan Sörensen, Stefanie-Yvonne Zimmermann, Stefan Schöning, Dirk Schwabe, Hans-Michael Kvasnicka, Raphaela Schwentner, Caroline Hutter, Thomas Lehrnbecher
Selective BRAF inhibitors such as vemurafenib have become a treatment option in patients with Langerhans cell Histiocytosis (LCH). To date, only 14 patients receiving vemurafenib for LCH have been reported. Although vemurafenib can stabilize the clinical condition of these patients, it does not seem to cure the patients, and it is unknown, when and how to stop vemurafenib treatment. We present a girl with severe multisystem LCH who responded only to vemurafenib. After 8 months of treatment, vemurafenib was tapered and replaced by prednisone and vinblastine, a strategy which has not been described to date...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29773267/update-on-research-and-clinical-translation-on-specific-clinical-areas-from-biology-to-bedside-unpacking-the-mysteries-of-juvenile-idiopathic-arthritis-pathogenesis
#16
REVIEW
Jorg van Loosdregt, Femke van Wijk, Berent Prakken, Bas Vastert
In the past decades, we have gained important insights into the mechanisms of disease and therapy underlying chronic inflammation in juvenile idiopathic arthritis (JIA). These insights have resulted in several game-changing therapeutic modalities for many patients. However, additional progress still has to be made with regard to efficacy, cost reduction, minimization of side effects, and dose-tapering and stop strategies of maintenance drugs. Moreover, to really transform the current therapeutic strategies into personalized medicine, we need validated biomarkers to translate increased insights into clinical practice...
August 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29771118/escherichia-coli-fiber-sensors-using-concentrated-dielectrophoretic-force-with-optical-defocusing-method
#17
Yi-Hsin Tai, Chia-Wei Lee, Dao-Ming Chang, Yu-Sheng Lai, Ding-Wei Huang, Pei-Kuen Wei
A sensitive tapered optical fiber tip combined with dielectrophoretic (DEP) trapping was used to rapid and label-free detection of bacteria in water. The angular spectrum of optical field at the fiber tip was changed with surrounding refractive index (RI). By measuring far-field intensity change at the defocus plane, the intensity sensitivity was up to 95,200 %/RIU (RI unit) and the detection limit was 2.1 × 10-6 RIU at 0.2% intensity stability. By applying an AC voltage to a Ti/Al coated fiber tip and an indium-tin-oxide glass, the DEP force effectively trapped the Escherichia coli (E...
May 17, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29769767/a-comparative-study-on-the-stress-distribution-around-dental-implants-in-three-arch-form-models-for-replacing-six-implants-using-finite-element-analysis
#18
Maryam Zarei, Mahmoud Jahangirnezhad, Hojatollah Yousefimanesh, Maryam Robati, Hossein Robati
Background: Dental implant is a method to replacement of missing teeth. It is important for replacing the missed anterior teeth. In vitro method is a safe method for evaluation of stress distribution. Finite element analysis as an in vitro method evaluated stress distribution around replacement of six maxillary anterior teeth implants in three models of maxillary arch. Materials and Methods: In this in vitro study, using ABAQUS software (Simulia Corporation, Vélizy-Villacoublay, France), implant simulation was performed for reconstruction of six maxillary anterior teeth in three models...
March 2018: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29767318/strategies-for-effective-discontinuation-of-proton-pump-inhibitors
#19
REVIEW
Judith Kim, John W Blackett, Daniela Jodorkovsky
PURPOSE OF REVIEW: Proton pump inhibitors (PPIs) are effective for many conditions but are often overprescribed. Recent concerns about long-term risks have made patients re-evaluate their need to take PPIs chronically, though these population-based studies have methodological weaknesses. The goal of this review is to provide evidenced-based strategies for discontinuation of PPI therapy. RECENT FINDINGS: Given that some patients experience rebound symptoms when abruptly stopping continuous PPI therapy due to its effect on hypergastrinemia, strategies focus on avoiding rebound...
May 16, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29766338/an-unusual-surgical-indication-for-cerebral-tuberculosis-status-dystonicus-case-report
#20
Andrea Franzini, Angelo Franzini, Vincenzo Levi, Roberto Cordella, Giuseppe Messina
Actual indications for surgery in tuberculosis are limited to obtaining a diagnosis, acquiring tissue for culture studies, treating hydrocephalus, aspiring a brain abscess, and reducing intracranial pressure in patients with multiple tuberculomas. Tuberculosis-related movement disorders are usually treated pharmacologically. We report on a child affected by post-tubercular generalized dystonia, who progressed to status dystonicus (SD) and underwent stereotactic bilateral pallidotomy. After surgery, SD resolved, and drugs were rapidly tapered...
May 15, 2018: Acta Neurochirurgica
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