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https://www.readbyqxmd.com/read/28749594/seizure-activity-per-se-does-not-induce-tissue-damage-markers-in-human-neocortical-focal-epilepsy
#1
Laura Rossini, Rita Garbelli, Vadym Gnatkovsky, Giuseppe Didato, Flavio Villani, Roberto Spreafico, Francesco Deleo, Giorgio Lo Russo, Giovanni Tringali, Francesca Gozzo, Laura Tassi, Marco de Curtis
Objective The contribute of recurring seizures to the progression of epileptogenesis is debated. Seizure-induced brain damage is not conclusively demonstrated both in humans and in animal models of epilepsy. We evaluated the expression of brain injury biomarkers on post-surgical brain tissue obtained from 20 patients with frequent seizures and a long history of drug-resistant focal epilepsy. Methods The expression patterns of specific glial, neuronal and inflammatory molecules was evaluated by immunohistochemistry in the core of type II focal cortical dysplasias (FCD-II), at the FCD boundary (perilesion) and in the adjacent normal-appearing area included in the epileptogenic region...
July 27, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28749553/myelopathy-in-beh%C3%A3-et-s-disease-the-bagel-sign
#2
Ugur Uygunoglu, Burcu Zeydan, Yesim Ozguler, Serdal Ugurlu, Emire Seyahi, Naci Kocer, Civan Islak, Kejal Kantarci, Sabahattin Saip, Aksel Siva, Orhun H Kantarci
OBJECTIVE: To describe the clinical and distinctive imaging features of myelopathy associated with Behçet's disease. METHODS: We evaluated the records of patients meeting the following criteria: a) fulfillment of the International Study Group criteria for Behçet's disease; b) clinically suggestive of myelopathy; c) simultaneous spinal cord and brain MRIs within 1 month of acute worsening of myelopathy; d) follow-up duration ≥1 year after initial MRI evaluation...
July 27, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28749498/black-tio2-based-core-shell-nanocomposites-as-doxorubicin-carriers-for-thermal-imaging-guided-synergistic-therapy-of-breast-cancer
#3
Wenzhi Ren, M Zubair Iqbal, Leyong Zeng, Tianxiang Chen, Yuanwei Pan, Jinshun Zhao, Hao Yin, Lili Zhang, Jichao Zhang, Aiguo Li, Aiguo Wu
TiO2 nanomaterials have been widely used for anticancer drug carriers and UV/980 nm NIR triggered cancer synergistic platforms. However, traditional pure TiO2 nanocarriers encounter some serious drawbacks, such as low drug loading ability, limited tissue penetration of UV light, and heating effect of 980 nm NIR on normal tissue, which obstruct their further application in cancer treatment. To overcome those challenges, novel mesoporous silica (mSiO2) coated black TiO2 core-shell nanocomposites are designed and constructed as doxorubicin carriers for 808 nm NIR triggered thermal imaging guided photothermal therapy combined chemotherapy of breast cancer...
July 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28749167/diagnostic-value-of-semiquantitative-and-quantitative-analysis-of-functional-parameters-in-multiparametric-mri-of-the-prostate
#4
Elke Hauth, Daniela Halbritter, Horst Jaeger, Horst Hohmuth, Meinrad Beer
OBJECTIVES: To determine the diagnostic value of semiquantitative and quantitative parameters of three functional techniques in multiparametric (mp)-MRI of the prostate. METHODS: Mp-MRI was performed in 110 patients with suspicion of prostate cancer (PCA) before TRUS-guided core biopsy. Peak-enhancement, initial and post-initial enhancement, iAUGC (initial area under gadolinium curve), Ktrans (forward rate constant), Kep (efflux rate constant), Ve (extracellular volume), ADC (apparent diffusion coefficient), and MR spectroscopy ratio were obtained for malignant and benign lesions...
July 27, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28749154/rude-color-glasses-the-contaminating-effects-of-witnessed-morning-rudeness-on-perceptions-and-behaviors-throughout-the-workday
#5
Andrew Woolum, Trevor Foulk, Klodiana Lanaj, Amir Erez
Using an experimental experience sampling design, we investigate how witnessing morning rudeness influences workers' subsequent perceptions and behaviors throughout the workday. We posit that a single exposure to rudeness in the morning can contaminate employees' perceptions of subsequent social interactions leading them to perceive greater workplace rudeness throughout their workday. We expect that these contaminated perceptions will have important ramifications for employees' work behaviors. In a 10-day study of 81 professional and managerial employees, we find that witnessed morning rudeness leads to greater perceptions of workplace rudeness throughout the workday and that those perceptions, in turn, predict lower task performance and goal progress and greater interaction avoidance and psychological withdrawal...
July 27, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28749017/large-institutional-variations-in-androgen-deprivation-therapy-utilization-with-definitive-radiotherapy-in-a-population-based-cohort-of-men-with-intermediate-and-high-risk-prostate-cancer
#6
Wee Loon Ong, Farshad Foroudi, Sue Evans, Jeremy Millar
OBJECTIVE: To evaluate the pattern of androgen deprivation therapy (ADT) utilization with definitive radiotherapy (RT) in men with prostate cancer (CaP) in a population-based study in Australia PATIENTS AND METHODS: This is a prospective cohort of men with intermediate and high-risk CaP captured in the population-based Prostate Cancer Outcome Registry Victoria (PCOR-Vic) treated with definitive prostate RT between January 2010 and December 2015. The primary outcome of interest is ADT utilization...
July 27, 2017: BJU International
https://www.readbyqxmd.com/read/28748878/assessment-of-hepatic-fibrosis-by-fibroscan-in-egyptian-chronic-hemodialysis-patients-with-chronic-hepatitis-c-genotype-4-a-single-center-study
#7
Bahaa El-Din Moustafa Zayed, Aisha Elsharkawy, Mahmoud Abdou, Dina Sabry Abd Al Fatah, Tarek Hussein El-Shabony
Assessing hepatic fibrosis in hemodialysis patients with chronic hepatitis C (CHC) can help to evaluate the long-term prognosis, complications of hepatitis C virus (HCV) as well as eligibility for renal transplantation,. Our aim was to assess liver fibrosis in Egyptian hemodialysis (HD) patients infected with CHC genotype 4 using a fibroscan. This cross-sectional observational study was conducted over two years on a cohort of 134 Egyptian patients on prevalent HD at Kasr Al Ainy Hospital. All patients were subjected to routine laboratory evaluation including, hepatitis B surface antigen, hepatitis B core antibody, hepatitis Be antigen, hepatitis C antibody (HCVAb) and human immunodeficiency virus antibody, quantitative polymerase chain reaction (PCR) for both HCV and hepatitis B virus (HBV), serum hyaluronic acid level, and alpha-fetoprotein (AFP)...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28748716/late-urinary-morbidity-and-quality-of-life-after-radical-prostatectomy-and-salvage-radiotherapy-for-prostate-cancer
#8
Maria Ervandian, Morten Høyer, Stine Elleberg Petersen, Lisa Sengeløv, Steinbjørn Hansen, Mette Moe Kempel, Peter Meidahl Petersen, Michael Borre
OBJECTIVE: There is a paucity of knowledge of long-term urinary morbidity in patients treated for prostate cancer (PCa) with radical prostatectomy (RP) and salvage radiotherapy (SRT). Improved long-term survival calls for heightened awareness of late effects from radiotherapy after RP. The purpose of this study was to assess late urinary morbidity and its potential impact on quality of life (QoL) in patients treated with RP plus SRT compared with patients treated with RP alone. MATERIALS AND METHODS: Long-term morbidity and QoL were evaluated using a cross-sectional design with validated questionnaires in urinary morbidity [Danish Prostatic Symptom Score (DAN-PSS)] and QoL [European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30)]...
July 27, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28748694/bilayered-nanoparticles-with-sequential-release-of-vegf-gene-and-paclitaxel-for-restenosis-inhibition-in-atherosclerosis
#9
Xiaowei Zhu, Hongzhi Xie, Xiaoyu Liang, Xuanling Li, Jianwei Duan, Yongxia Chen, Ziying Yang, Chao Liu, Cuiwei Wang, Hailing Zhang, Quan Fang, Hongfan Sun, Chen Li, Yongjun Li, Chun Wang, Cunxian Song, Yong Zeng, Jing Yang
Complete re-endothelialization followed by inhibition of smooth muscle cell proliferation is considered an effective therapeutic option to prevent restenosis. We have designed poly(lactide-co-glycolide)-loaded bilayered nanoparticles (NPs) with the ability to sequentially release VEGF-encoding plasmids from the outer layer and paclitaxel (PTX) from the core to promote endothelial regeneration while also prevent restenosis. Comparing with conventional NPs, which release VEGF plasmid and PTX simultaneously, we expect that the bilayered NPs could release the VEGF plasmid more rapidly followed by a delayed release of PTX, resulting in efficient VEGF gene transfection, which ideally could promote re-endothelialization while inhibit excessive smooth muscle cell growth...
July 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28748598/an-evaluation-of-the-effectiveness-of-psychological-therapy-in-reducing-general-psychological-distress-for-adults-with-autism-spectrum-conditions-and-comorbid-mental-health-problems
#10
Sarah H Blainey, Freya Rumball, Louise Mercer, Lauren Jayne Evans, Alison Beck
OBJECTIVE: To investigate the effectiveness of psychological therapy in reducing psychological distress for adults with autism spectrum conditions (ASC) and co-morbid mental health conditions in routine clinical practice. To explore the effect of individual characteristics and service factors on change in general distress. METHOD: In a specialist psychological therapies service for adults with ASC, the Clinical Outcomes in Routine Evaluation-Outcome Measure (CORE-OM) self-report questionnaire of psychological distress is completed by clients at start and end of therapy...
July 26, 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/28748511/unique-histologic-features-of-tonsils-from-patients-with-periodic-fever-aphthous-stomatitis-pharyngitis-and-cervical-adenitis-pfapa-syndrome
#11
Kalpana Manthiram, Hernan Correa, Kelli Boyd, Joseph Roland, Kathryn Edwards
The objective of this study is to compare the histology and immune cell composition of tonsils from patients with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome to those from patients with obstructive sleep apnea (OSA). Patients with PFAPA and age-matched controls with OSA who had undergone tonsillectomy at Vanderbilt Children's Hospital were recruited. After informed consent, archival paraffin-embedded, formalin-fixed tonsil tissues were obtained. Sizes of major histologic regions were measured...
July 26, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28748505/comparison-of-consecutive-results-from-fine-needle-aspiration-and-core-needle-biopsy-in-thyroid-nodules
#12
Soon-Hyun Ahn, So-Yeon Park, Sang Il Choi
There are papers suggesting the complementary role of core needle biopsy (CNB) in the diagnosis of thyroid nodules. By comparing the result of CNB and fine needle aspiration (FNA) cytology performed in consecutive cases of thyroid nodules, the role of CNB was evaluated. Retrospective reviews of 2131 FNA and 275 CNB which were performed as first-line biopsy for 2406 thyroid nodules in 2187 patients were performed. The ultrasound (US) feature of thyroid nodule was classified following the risk of malignancy suggested by American Thyroid Association (ATA) guideline...
July 26, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28747004/the-stability-and-removal-of-water-dispersed-cdse-cds-core-shell-quantum-dots-from-water
#13
Xu Chen, Yong Sik Ok, Dinesh Mohan, Charles U Pittman, Xiaomin Dou
The increasingly wide use of semiconductor nanocrystals inevitably leads to their release into aquatic environment. The aggregation behaviors of 3-mercaptopropionic acid-capped CdSe/CdS core-shell quantum dots (MPA-QDs) under various water chemistry conditions were examined and their removal using Fe(3+) and Al(3+) coagulants was evaluated. Cationic species rather than concentrations affected the stability of MPA-QDs. Adding 2 mM Ca(2+) led to a much larger ζ-potential decrease and particle size increase than adding 150 mM K(+) at each tested solution pH...
July 17, 2017: Chemosphere
https://www.readbyqxmd.com/read/28746957/-need-for-information-about-medical-rehabilitation-of-persons-with-german-pension-insurance-a-written-survey
#14
Anna Lena Walther, Johannes Falk, Ruth Deck
Aim In order to acquire target group-specific information on rehabilitation for members of the German pension insurance, they were asked about their ideas about medical rehabilitation and desired information regarding subjects and kind of information transfer. Method The core of the project was a written survey of members of the German pension insurance. N=600 insured people were invited to participate in the study. The questionnaire was developed in a qualitative pre-study. Results N=196 questionnaires were evaluated...
July 26, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28745644/profiling-anti-neu5gc-igg-in-human-sera-with-a-sialoglycan-microarray-assay
#15
Shani Leviatan Ben-Arye, Hai Yu, Xi Chen, Vered Padler-Karavani
Cells are covered with a cloak of carbohydrate chains (glycans) that is commonly altered in cancer and that includes variations in sialic acid (Sia) expression. These are acidic sugars that have a 9-carbon backbone and that cap vertebrate glycans on cell surfaces. Two of the major Sia forms in mammals are N-acetylneuraminic acid (Neu5Ac) and its hydroxylated form, N-glycolylneuraminic acid (Neu5Gc). Humans cannot produce endogenous Neu5Gc due to the inactivation of the gene encoding cytidine 5'monophosphate-Neu5Ac (CMP-Neu5Ac) hydroxylase (CMAH)...
July 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28745578/cost-effectiveness-of-g5-mobile-continuous-glucose-monitoring-cgm-device-compared-with-self-monitoring-of-blood-glucose-smbg-alone-for-people-with-type-1-diabetes-from-the-canadian-societal-perspective
#16
Shraddha Chaugule, Claudia Graham
AIMS: To evaluate the cost-effectiveness of real-time continuous glucose monitoring (CGM) compared to self-monitoring of blood glucose (SMBG) alone in people with type 1 diabetes (T1DM) using multiple daily injections (MDI) from the Canadian societal perspective. METHODS: The IMS CORE Diabetes Model (v.9.0) was used to assess the long-term (50 years) cost-effectiveness of real-time CGM (G5 Mobile CGM System; Dexcom, Inc., San Diego, CA) compared with SMBG alone for a cohort of adults with poorly-controlled T1DM...
July 26, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28745540/p53-and-mdm2-act-synergistically-to-maintain-cardiac-homeostasis-and-mediate-cardiomyocyte-cell-cycle-arrest-through-a-network-of-micrornas
#17
Shanna Stanley-Hasnain, Ludger Hauck, Daniela Grothe, Roozbeh Aschar-Sobbi, Sanja Beca, Jagdish Butany, Peter H Backx, Tak W Mak, Filio Billia
Defining the roadblocks responsible for cell cycle arrest in adult cardiomyocytes lies at the core of developing cardiac regenerative therapies. p53 and Mdm2 are crucial mediators of cell cycle arrest in proliferative cell types, however little is known about their function in regulating homeostasis and proliferation in terminally differentiated cell types, like cardiomyocytes. To explore this, we generated a cardiac-specific conditional deletion of p53 and Mdm2 (DKO) in adult mice. Herein we describe the development of a dilated cardiomyopathy, in the absence of cardiac hypertrophy...
July 26, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28745231/synthesis-and-antimalarial-activity-of-new-enantiopure-aminoalcoholpyrrolo-1-2-a-quinoxalines
#18
Alexia Jonet, Jean Guillon, Catherine Mullié, Anita Cohen, Guillaume Bentzinger, Jérémy Schneider, Nicolas Taudon, Sebastien Hutter, Nadine Azas, Stephane Moreau, Solene Savrimoutou, Patrice Agnamey, Alexandra Dassonville-Klimpt, Pascal Sonnet
Backgroung: We prepared a novel series of enantiopure mefloquine analogues with pyrrolo[1,2-a]quinoxaline core in order to fight Plasmodium falciparum resistant strain. OBJECTIVES: To observe the influence of pyrrolo[1,2-a]quinoxaline core versus quinoline core on the antimalarial activity. METHOD: Four enantiopure aminoalcoholpyrrolo[1,2-a]quinoxalines 2 were synthetized via Sharpless asymmetric dihydroxylation reaction in eight steps. Their antimalarial activity was evaluated on two Plasmodium falciparum strains 3D7 and W2 with a SYBR Green I fluorescence-based method and their cytotoxicity was measured on four cell lines HepG2, THP-1, CHO and HFF...
July 26, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28744970/evaluation-of-a-professional-development-training-programme-for-mental-health-clinicians-specializing-in-early-psychosis
#19
Craig Macneil, Frances Foster, Amanda Nicoll, Helen Osman, Richard Monfries, Sue Cotton
The Early Psychosis Prevention and Intervention Centre Statewide Services (ESW) team provides training for multidisciplinary clinicians that specialise in early psychosis across the State of Victoria, Australia. The aim of this paper is to describe the 4-phase approach utilised by ESW to prepare for and deliver workshops, to report on participants' ratings of the ESW workshops, and to make recommendations for other trainers of early psychosis clinicians. Between March 2009 and September 2014, ESW provided 85 training workshops that had a strong focus on evidence-based approaches and international guidelines, and utilized clinical examples of early psychosis interventions...
July 26, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28743589/density-functionalized-ru-ii-no-salen-cl-complex-computational-photodynamics-and-in-vitro-anticancer-facets
#20
Jan Mohammad Mir, N Jain, P S Jaget, R C Maurya
Photodynamic therapy (PDT) is a treatment that uses photosensitizing agents to kill cancer cells. Scientific community has been eager for decades in enduring curiosity to design an efficient PDT drug. Under such purview, the current report deals with the computational photodynamic behavior of ruthenium(II) nitrosyl complex containing N, N'-salicyldehyde-ethylenediimine (SalenH2), the synthesis and X-ray crystallography of which is already known [Ref. 36]. Gaussian 09W software package was employed to carry out the density functional (DFT) studies...
July 22, 2017: Photodiagnosis and Photodynamic Therapy
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