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https://www.readbyqxmd.com/read/28102893/the-evolving-health-policy-landscape-and-suggested-geriatric-tenets-to-guide-future-responses
#1
Robert L Kane, Debra Saliba, Peter Hollmann
Speculation is rampant about what the new leadership in the White House and continued Republican leadership of both houses of Congress will do about health care. The concordance in party affiliation between President Trump and the congressional majority makes revisions in policy that is relevant to the health of older adults a virtual certainty. Past Republican legislative proposals and the current appointments to lead Health and Human Services (HHS) and the Centers for Medicare & Medicaid Services (CMS) presage several potential areas of change...
January 19, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28102493/a-meta-analysis-of-working-memory-impairments-in-autism-spectrum-disorders
#2
REVIEW
Ya Wang, Yi-Bing Zhang, Lu-Lu Liu, Ji-Fang Cui, Jing Wang, David H K Shum, Therese van Amelsvoort, Raymond C K Chan
Autism spectrum disorders (ASD) are characterized by executive dysfunction, and working memory (WM) comprises one core component of executive function. Many studies have investigated WM impairments in individuals with ASD, however, a conclusive agreement has not been reached. The present study provided a meta-analytic review of WM impairments in individuals with ASD and evaluated potential moderating variables of this problem. Twenty-eight studies were included in this study, and the participants comprised 819 individuals with ASD and 875 healthy controls...
January 19, 2017: Neuropsychology Review
https://www.readbyqxmd.com/read/28101126/characterisation-of-microbial-communities-within-aggressive-prostate-cancer-tissues
#3
Melissa A Yow, Sepehr N Tabrizi, Gianluca Severi, Damien M Bolton, John Pedersen, Graham G Giles, Melissa C Southey
BACKGROUND: An infectious aetiology for prostate cancer has been conjectured for decades but the evidence gained from questionnaire-based and sero-epidemiological studies is weak and inconsistent, and a causal association with any infectious agent is not established. We describe and evaluate the application of new technology to detect bacterial and viral agents in high-grade prostate cancer tissues. The potential of targeted 16S rRNA gene sequencing and total RNA sequencing was evaluated in terms of its utility to characterise microbial communities within high-grade prostate tumours...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28100689/effectiveness-and-duration-of-protection-of-one-dose-of-a-meningococcal-conjugate-vaccine
#4
Amanda C Cohn, Jessica R MacNeil, Lee H Harrison, Ruth Lynfield, Arthur Reingold, William Schaffner, Elizabeth R Zell, Brian Plikaytis, Xin Wang, Nancy E Messonnier
BACKGROUND: Meningococcal conjugate vaccines were licensed beginning in 2005 on the basis of serologic end points and recommended for use in adolescents. A single dose at age 11 to 12 years was expected to provide protection through late adolescence. We conducted a case-control evaluation of vaccine effectiveness (VE) and duration of protection of a meningococcal (groups A, C, W, and Y) polysaccharide diphtheria toxoid conjugate vaccine (MenACWY-D). METHODS: Cases of culture- or polymerase chain reaction-confirmed serogroup A, C, W, and Y meningococcal disease among adolescents were identified through meningococcal disease surveillance sites in the United States from January 1, 2006, through August 31, 2013...
January 18, 2017: Pediatrics
https://www.readbyqxmd.com/read/28099950/nano-particles-assembled-porous-core-shell-znmn2o4-microspheres-with-superb-performance-for-lithium-batteries
#5
Tong Zhang, Huijuan Yue, Hailong Qiu, Wei Yingjin, Chunzhong Wang, Gang Chen, Zhang Dong
Porous ZnMn2O4 microspheres were prepared via a facile co-precipitation method followed by calcination at various temperatures and evaluated as anode materials for Lithium ion batteries. The sample prepared at 600��C outperformed the other samples in terms of electrochemical performance with high reversible capacity, high-rate capability, and excellent cycling performance. The capacity of the sample remained as high as 999 mAh g-1 at a current rate of 100 mA g-1 after 50 cycles ��� one of the best ever reported for ZnMn2O4-based materials...
January 18, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28099309/the-core-competencies-for-general-orthopaedic-surgeons
#6
James F Kellam, Douglas Archibald, James W Barber, Eugene P Christian, Richard J D'Ascoli, Richard J Haynes, Suzanne S Hecht, Shepard R Hurwitz, James F Kellam, Alexander C McLaren, Terrance D Peabody, Stephen R Southworth, Robert W Strauss, Veronica M R Wadey
BACKGROUND: With the changing delivery of orthopaedic surgical care, there is a need to define the knowledge and competencies that are expected of an orthopaedist providing general and/or acute orthopaedic care. This article provides a proposal for the knowledge and competencies needed for an orthopaedist to practice general and/or acute care orthopaedic surgery. METHODS: Using the modified Delphi method, the General Orthopaedic Competency Task Force consisting of stakeholders associated with general orthopaedic practice has proposed the core knowledge and competencies that should be maintained by orthopaedists who practice emergency and general orthopaedic surgery...
January 18, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28099178/clinical-performance-evaluations-of-third-year-medical-students-and-association-with-student-and-evaluator-gender
#7
Alison Riese, Leah Rappaport, Brian Alverson, Sangshin Park, Randal M Rockney
PURPOSE: Clinical performance evaluations are major components of medical school clerkship grades. But are they sufficiently objective? This study aimed to determine whether student and evaluator gender is associated with assessment of overall clinical performance. METHOD: This was a retrospective analysis of 4,272 core clerkship clinical performance evaluations by 829 evaluators of 155 third-year students, within the Alpert Medical School grading database for the 2013-2014 academic year...
January 17, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28098834/volatile-compound-profiling-by-hs-spme-gc-ms-fid-of-a-core-olive-cultivar-collection-as-a-tool-for-aroma-improvement-of-virgin-olive-oil
#8
Lourdes García-Vico, Angjelina Belaj, Araceli Sánchez-Ortiz, José M Martínez-Rivas, Ana G Pérez, Carlos Sanz
Virgin olive oil (VOO) is the only food product requiring official sensory analysis to be classified in commercial categories, in which the evaluation of the aroma plays a very important role. The selection of parents, with the aim of obtaining new cultivars with improved oil aroma, is of paramount importance in olive breeding programs. We have assessed the volatile fraction by headspace-solid-phase microextraction/gas chromatography-mass spectrometry-flame ionization detection (HS-SPME/GC-MS-FID) and the deduced aroma properties of VOO from a core set of olive cultivars (Core-36) which possesses most of the genetic diversity found in the World Olive Germplasm Collection (IFAPA Alameda del Obispo) located in Cordoba, Spain...
January 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28098622/physician-assisted-suicide-and-euthanasia-in-the-icu-a-dialogue-on-core-ethical-issues
#9
Ewan C Goligher, E Wesley Ely, Daniel P Sulmasy, Jan Bakker, John Raphael, Angelo E Volandes, Bhavesh M Patel, Kate Payne, Annmarie Hosie, Larry Churchill, Douglas B White, James Downar
OBJECTIVE: Many patients are admitted to the ICU at or near the end of their lives. Consequently, the increasingly common debate regarding physician-assisted suicide and euthanasia holds implications for the practice of critical care medicine. The objective of this article is to explore core ethical issues related to physician-assisted suicide and euthanasia from the perspective of healthcare professionals and ethicists on both sides of the debate. SYNTHESIS: We identified four issues highlighting the key areas of ethical tension central to evaluating physician-assisted suicide and euthanasia in medical practice: 1) the benefit or harm of death itself, 2) the relationship between physician-assisted suicide and euthanasia and withholding or withdrawing life support, 3) the morality of a physician deliberately causing death, and 4) the management of conscientious objection related to physician-assisted suicide and euthanasia in the critical care setting...
February 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28097745/immature-core-protein-of-hepatitis-c-virus-induces-an-unfolded-protein-response-through-inhibition-of-erad-l-in-a-yeast-model-system
#10
Shota Takahashi, Naoko Sato, Junichi Kikuchi, Hideaki Kakinuma, Jun Okawa, Yukiko Masuyama, Singo Iwasa, Hayato Irokawa, Gi-Wook Hwang, Akira Naganuma, Michinori Kohara, Shusuke Kuge
The structural protein Core of hepatitis C virus (HCV), a cytosolic protein, induces endoplasmic reticulum (ER) stress and unfolded protein response (UPR) in hepatocytes, and is responsible for the pathogenesis of persistent HCV infection. Using yeast as a model system, we evaluated mechanisms underlying Core-induced interference of ER homeostasis and UPR, and found that UPR is induced by the immature Core (aa 1-191, Core191) but not by the mature Core (aa 1-177, Core177). Interestingly, Core191 inhibits both ERAD-L, a degradation system responsible for misfolded/unfolded proteins in the ER lumen, and ERAD-M, a degradation system responsible for proteins carrying a misfolded/unfolded region in the ER membrane...
January 18, 2017: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/28097310/combined-intravenous-thrombolysis-and-thrombectomy-vs-thrombectomy-alone-for-acute-ischemic-stroke-a-pooled-analysis-of-the-swift-and-star-studies
#11
Jonathan M Coutinho, David S Liebeskind, Lee-Anne Slater, Raul G Nogueira, Wayne Clark, Antoni Dávalos, Alain Bonafé, Reza Jahan, Urs Fischer, Jan Gralla, Jeffrey L Saver, Vitor M Pereira
Importance: Mechanical thrombectomy (MT) improves clinical outcomes in patients with acute ischemic stroke (AIS) caused by a large vessel occlusion. However, it is not known whether intravenous thrombolysis (IVT) is of added benefit in patients undergoing MT. Objective: To examine whether treatment with IVT before MT with a stent retriever is beneficial in patients undergoing MT. Design, Setting, and Participants: This post hoc analysis used data from 291 patients treated with MT included in 2 large, multicenter, prospective clinical trials that evaluated MT for AIS (Solitaire With the Intention for Thrombectomy performed from January 1, 2010, through December 31, 2011, and Solitaire Flow Restoration Thrombectomy for Acute Revascularization from January 1, 2010, through December 31, 2012)...
January 9, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28096727/new-radiofrequency-device-to-reduce-bleeding-after-core-needle-biopsy-experimental-study-in-a-porcine-liver-model
#12
Sanghyeok Lim, Hyunchul Rhim, Min Woo Lee, Kyoung Doo Song, Tae Wook Kang, Young-Sun Kim, Hyo Keun Lim
OBJECTIVE: To evaluate the in vivo efficiency of the biopsy tract radiofrequency ablation for hemostasis after core biopsy of the liver in a porcine liver model, including situations with bleeding tendency and a larger (16-gauge) core needle. MATERIALS AND METHODS: A preliminary study was performed using one pig to determine optimal ablation parameters. For the main experiment, four pigs were assigned to different groups according to heparinization use and biopsy needle caliber...
January 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28096235/role-of-cardiotrophin-1-in-the-regulation-of-metabolic-circadian-rhythms-and-adipose-core-clock-genes-in-mice-and-characterization-of-24-h-circulating-ct-1-profiles-in-normal-weight-and-overweight-obese-subjects
#13
Miguel López-Yoldi, Kimber L Stanhope, Marta Garaulet, X Guoxia Chen, Beatriz Marcos-Gómez, María Paz Carrasco-Benso, Eva M Santa Maria, Xavier Escoté, Vivien Lee, Marinelle V Nunez, Valentina Medici, Eduardo Martínez-Ansó, Neira Sáinz, Ana E Huerta, Laura M Laiglesia, Jesús Prieto, J Alfredo Martínez, Matilde Bustos, Peter J Havel, Maria J Moreno-Aliaga
Cardiotrophin (CT)-1 is a regulator of glucose and lipid homeostasis. In the present study, we analyzed whether CT-1 also acts to peripherally regulate metabolic rhythms and adipose tissue core clock genes in mice. Moreover, the circadian pattern of plasma CT-1 levels was evaluated in normal-weight and overweight subjects. The circadian rhythmicity of oxygen consumption rate (Vo2) was disrupted in aged-obese CT-1-deficient (CT-1(-/-)) mice (12 mo). Although circadian rhythms of Vo2 were conserved in young-lean CT-1(-/-) mice (2 mo), CT-1 deficiency caused a phase shift of the acrophase...
January 17, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28095853/crispri-mediated-metabolic-engineering-of-e-coli-for-o-methylated-anthocyanin-production
#14
Brady F Cress, Quentin D Leitz, Daniel C Kim, Teresita D Amore, Jon Y Suzuki, Robert J Linhardt, Mattheos A G Koffas
BACKGROUND: Anthocyanins are a class of brightly colored, glycosylated flavonoid pigments that imbue their flower and fruit host tissues with hues of predominantly red, orange, purple, and blue. Although all anthocyanins exhibit pH-responsive photochemical changes, distinct structural decorations on the core anthocyanin skeleton also cause dramatic color shifts, in addition to improved stabilities and unique pharmacological properties. In this work, we report for the first time the extension of the reconstituted plant anthocyanin pathway from (+)-catechin to O-methylated anthocyanins in a microbial production system, an effort which requires simultaneous co-option of the endogenous metabolites UDP-glucose and S-adenosyl-L-methionine (SAM or AdoMet)...
January 17, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28095811/an-integrated-recovery-oriented-model-irm-for-mental-health-services-evolution-and-challenges
#15
Barry G Frost, Srinivasan Tirupati, Suzanne Johnston, Megan Turrell, Terry J Lewin, Ketrina A Sly, Agatha M Conrad
BACKGROUND: Over past decades, improvements in longer-term clinical and personal outcomes for individuals experiencing serious mental illness (SMI) have been moderate, although recovery has clearly been shown to be possible. Recovery experiences are inherently personal, and recovery can be complex and non-linear; however, there are a broad range of potential recovery contexts and contributors, both non-professional and professional. Ongoing refinement of recovery-oriented models for mental health (MH) services needs to be fostered...
January 17, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28095522/correlation-between-resonance-frequency-analysis-and-bone-quality-assessments-at-dental-implant-recipient-sites
#16
Min-Wen Fu, Earl Fu, Fu-Gong Lin, Wei-Jeng Chang, Yao-Dung Hsieh, E-Chin Shen
PURPOSE: To evaluate whether primary implant stability could be used to predict bone quality, the association between the implant stability quotient (ISQ) value and the bone type at the implant site was evaluated. MATERIALS AND METHODS: Ninety-five implant sites in 50 patients were included. Bone type (categorized by Lekholm and Zarb) at the implant site was initially assessed using presurgical dental radiography. During the preparation of the implant site, a bone core specimen was carefully obtained...
January 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28095468/evaluating-hospital-based-surveillance-for-outbreak-detection-in-bangladesh-analysis-of-healthcare-utilization-data
#17
Birgit Nikolay, Henrik Salje, Katharine Sturm-Ramirez, Eduardo Azziz-Baumgartner, Nusrat Homaira, Makhdum Ahmed, A Danielle Iuliano, Repon C Paul, Mahmudur Rahman, M Jahangir Hossain, Stephen P Luby, Simon Cauchemez, Emily S Gurley
BACKGROUND: The International Health Regulations outline core requirements to ensure the detection of public health threats of international concern. Assessing the capacity of surveillance systems to detect these threats is crucial for evaluating a country's ability to meet these requirements. METHODS AND FINDINGS: We propose a framework to evaluate the sensitivity and representativeness of hospital-based surveillance and apply it to severe neurological infectious diseases and fatal respiratory infectious diseases in Bangladesh...
January 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28094897/cytology-assessment-can-predict-survival-for-patients-with-metastatic-pancreatic-neuroendocrine-neoplasms
#18
Carlie S Sigel, Huimin Guo, Keith M Sigel, Ming Zhang, Natasha Rekhtman, Oscar Lin, David S Klimstra, Achim A Jungbluth, Laura K Tang
BACKGROUND: Histological features and Ki-67 index have known usefulness in predicting prognosis and guiding therapy among patients with metastatic pancreatic neuroendocrine neoplasms. Fine-needle aspiration may offer advantages for Ki-67 assessment because the technique obtains highly cellular, well-preserved specimens with the potential for broader tumor sampling. In the current study, the authors evaluated concordance for grade and differentiation between concurrent core needle biopsy and cytology preparations...
January 17, 2017: Cancer
https://www.readbyqxmd.com/read/28094539/genetic-diversity-and-population-structure-of-castor-ricinus-communis-l-germplasm-within-the-us-collection-assessed-with-est-ssr-markers
#19
M L Wang, M Dzievit, Z Chen, J B Morris, J E Norris, N A Barkley, B Tonnis, G A Pederson, J Yu
Castor is an important oilseed crop and although its oil is inedible, it has multiple industrial and pharmaceutical applications. The entire US castor germplasm collection was previously screened for oil content and fatty acid composition, but its genetic diversity and population structure has not been determined. Based on the screening results of oil content, fatty acid composition, and country origins, 574 accessions were selected and genotyped with 22 polymorphic EST-SSR markers. The results from cluster analysis, population structure, and principal component analysis were consistent, and partitioned accessions into four subpopulations...
October 14, 2016: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28094297/high-throughput-quantitation-of-inorganic-nanoparticle-biodistribution-at-the-single-cell-level-using-mass-cytometry
#20
Yu-Sang Sabrina Yang, Prabhani U Atukorale, Kelly D Moynihan, Ahmet Bekdemir, Kavya Rakhra, Li Tang, Francesco Stellacci, Darrell J Irvine
Inorganic nanoparticles (NPs) are studied as drug carriers, radiosensitizers and imaging agents, and characterizing nanoparticle biodistribution is essential for evaluating their efficacy and safety. Tracking NPs at the single-cell level with current technologies is complicated by the lack of reliable methods to stably label particles over extended durations in vivo. Here we demonstrate that mass cytometry by time-of-flight provides a label-free approach for inorganic nanoparticle quantitation in cells. Furthermore, mass cytometry can enumerate AuNPs with a lower detection limit of ∼10 AuNPs (3 nm core size) in a single cell with tandem multiparameter cellular phenotyping...
January 17, 2017: Nature Communications
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