Taka-Aki Masuda, Akemi Kataoka, Shinji Ohno, Shigeru Murakami, Koshi Mimori, Tohru Utsunomiya, Hiroshi Inoue, Shinichi Tsutsui, Junko Kinoshita, Norikazu Masuda, Noriyuki Moriyama, Masaki Mori
The clinical significance of occult micrometastasis (O.M) remains unknown. We investigated it in peripheral blood (P.B.) and bone marrow (B.M.) in breast cancer patients with surgery. First, we investigated the expression levels of 7 representative molecular markers for detecting O.M (CEA, CK-7, CK-18, CK-19, CK-20, MAM and MUC-1) in 27 cancer and 8 non-epithelial cell lines using quantitative RT-PCR (QRT-PCR), and showed that the expression level of CK-7 was higher in every cancer cell line than in the non-epithelial cell lines...
March 2005: International Journal of Oncology