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Taka-Aki Masuda, Akemi Kataoka, Shinji Ohno, Shigeru Murakami, Koshi Mimori, Tohru Utsunomiya, Hiroshi Inoue, Shinichi Tsutsui, Junko Kinoshita, Norikazu Masuda, Noriyuki Moriyama, Masaki Mori
The clinical significance of occult micrometastasis (O.M) remains unknown. We investigated it in peripheral blood (P.B.) and bone marrow (B.M.) in breast cancer patients with surgery. First, we investigated the expression levels of 7 representative molecular markers for detecting O.M (CEA, CK-7, CK-18, CK-19, CK-20, MAM and MUC-1) in 27 cancer and 8 non-epithelial cell lines using quantitative RT-PCR (QRT-PCR), and showed that the expression level of CK-7 was higher in every cancer cell line than in the non-epithelial cell lines...
March 2005: International Journal of Oncology
Aki Nakayama, Yoshihiro Noguchi, Toshiaki Mori, Shinsuke Morisawa, Takashi Yagi
Benzene is a human leukemogen and the metabolites are thought to be deeply involved in benzene leukemogenesis. In a previous study we reported the molecular analysis of p-benzoquinone (p-BQ) mutagenesis by using a supF shuttle vector plasmid and here we report the mutagenesis of the other metabolites, hydroquinone (HQ) and trans, trans-muconaldehyde (MUC). HQ is a precursor of p-BQ and MUC is produced by a ring-opening metabolic pathway. We found that the HQ redox cycle produced an oxidative lesion in plasmid DNA and significant differences among the mutagenic potentials of MUC, HQ and p-BQ...
March 2004: Mutagenesis
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