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Diabeted melitus

Wirawan Adikusuma, Nurul Qiyaam
Poor adherence and a lack of understanding of medication instructions for oral antidiabetic use are key factors that inhibit the control of glycemic levels. The aforementioned situation needs intervention to improve medication adherence and the therapy. This study was conducted with a quasi-experimental design with prospective data collection. The subjects of this study were 50 outpatients with type 2 diabetes melitus (T2DM) who had received oral antidiabetic medicine therapy at least six months prior to adherence measurement...
May 12, 2017: Scientia Pharmaceutica
Pulkit Sethi, Manoj Thillai, Prabhdeep Singh Nain, Ashish Ahuja, Sudheer Othiyil Vayoth, Preetika Khurana
INTRODUCTION: Increasing incidence of obesity in Indian population has led to an exponential rise in the number of bariatric operations performed annually. Laparoscopic Sleeve Gastrectomy (LSG) has been proposed to cause rapid remission of Type 2 Diabetes Melitus (T2DM) and metabolic syndrome in a weight loss independent manner. AIM: To evaluate the effects of LSG on metabolic syndrome and central obesity in morbidly and severely obese Indian adults. Material and Methods: Study was conducted on 91 morbidly obese [Body Mass Index (BMI)>40 kg/m(2)] and severely obese (BMI>35 kg/m(2)) individuals who were suffering from diabetes, hypertension or dyslipidemia...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
Mogens Fenger, Dorte Lindqvist Hansen, Dorte Worm, Lisbeth Hvolris, Viggo B Kristiansen, Elin Rebecka Carlsson, Sten Madsbad
BACKGROUND: Roux-en-Y gastric bypass surgery is widely applied to ameliorate morbid obesity, including diabetes in people with type 2 diabetes. The latter vanish a few days after surgery for many, but not in all patients before any weight reduction has occurred. The explanation for this change in metabolic status is poorly understood, but the observation may suggest that the fate obesity and diabetes is only partly linked after surgery. METHODS: The trajectories of weight reduction measured as reduced body mass index (BMI) in 741obese subjects with and without diabetes were evaluated...
November 9, 2016: BMC Endocrine Disorders
Cosmin Caraşca, Angela Borda, Alexandru Incze, Emilian Caraşca, Attila Frigy, HoraŢiu Suciu
We present the case of a 55-year-old male with mild hypertension and brief episodes of paroxysmal self-limiting atrial fibrillation (AF) since 2010. Despite a small cardioembolic risk score, CHA2DS2-Vasc=1 (Congestive heart failure, Hypertension, Age=75, Diabetes melitus, prior Stroke), the patient is effectively anticoagulated using acenocumarol. In December 2014, he showed signs of plantar transitory ischemia, for which he did not address the doctor. In early January 2015, he urgently presented at the hospital with left renal pain, caused by a renal infarction, diagnosed by computed tomography (CT) angiography...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
R T Grimes, K Bennett, M Henman
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
N M Danchenko, S P Vesel'skyĭ, B O Tsudzevych
The ratio of bile acids in the bile of rats with alloxan diabetes was investigated using the method of thin-layer chromatography. Changes of coefficients of conjugation and hydroxylation of bile acids were calculated and analyzed in half-hour samples of bile obtained during the 3-hour experiment. It has been found that the processes of conjugation of cholic acid with glycine and taurine are inhibited in alloxan diabetes. At the same time a significant increase of free threehydroxycholic and dixydroxycholic bile acids and conjugates of the latter ones with taurine has been registered...
November 2014: Ukrainian Biochemical Journal
Saurabh RamBihariLal Shrivastava, Arun Gangadhar Ghorpade
BACKGROUND: We aimed to assess the prevalence of type-2 diabetes in rural Pondicherry and to study the determinants of Diabetes Mellitus (DM) in the rural population of Pondicherry, south Induia. METHODS: It was a cross-sectional community-based study conducted from November 2010 to January 2012 in two of the field practice villages affiliated to a Medical College in Pondicherry. Sample size was calculated using open source software, Open Epi Version 2.3.10. The sampling frame comprised individuals aged above 25 years and single stage cluster random sampling was carried out...
2014: Journal of Research in Health Sciences
Joel P Arrais, Nuno Rosa, José Melo, Edgar D Coelho, Diana Amaral, Maria José Correia, Marlene Barros, José Luís Oliveira
OBJECTIVES: The molecular complexity of the human oral cavity can only be clarified through identification of components that participate within it. However current proteomic techniques produce high volumes of information that are dispersed over several online databases. Collecting all of this data and using an integrative approach capable of identifying unknown associations is still an unsolved problem. This is the main motivation for this work. RESULTS: We present the online bioinformatic tool OralCard, which comprises results from 55 manually curated articles reflecting the oral molecular ecosystem (OralPhysiOme)...
July 2013: Archives of Oral Biology
(no author information available yet)
It was conducted a study of glutamine cardioptotective effects during perioperative use in patients with ischemic heart disease, operated under CB. Exclusion criteria were: left ventricular ejection fraction less than 50%, diabetes melitus, myocardial infarction less than 3 months ago, Patients of the study group (n=25) had glutamine (20% solution N(2)-L-alanine-L-glutamine ("Dipeptiven" Fresenius Kabi, Germany); 0.4 g/kg/day. Patients of control group (n=25) received placebo (0.9% NaCl solution). The main indicators were the dynamics of troponin I, as well as central hemodynamics parameters...
March 2012: Anesteziologiia i Reanimatologiia
Ewa Pańkowska
Diabetes is a metabolic disease defined by increased blood glucose level above the references value. Insulin therapy is mandatory for all patients with type 1 diabetes melitus (T1DM). However, the insulin therapy is also the potential factor of hyperglycemia as well as hypoglycemia condition called dysglycemia. Moreover, T1DM leads to late organ changes such as retinopathy and nephropathy primarily due to diabetic angiopathy. Neuropathy is one of diabetic complications which can occur from the beginning of the disease...
January 2012: Medycyna Wieku Rozwojowego
M Trojan-Rodrigues, T L S Alves, G L G Soares, M R Ritter
ETHNOPHARMACOLOGICAL RELEVANCE: Plants are widely as antidiabetics. The study of these plants is essential because many of them may have undesirable effects, such as acute or chronic toxicity; or their use may even delay or discourage the adoption of the proper and effective treatment. MATERIALS AND METHODS: The present study surveyed the plant species that are popularly used to treat diabetes mellitus in the state of Rio Grande do Sul in southern Brazil. Sixteen ethnobotanical surveys performed in the state were consulted, and the species used to treat diabetes were listed...
January 6, 2012: Journal of Ethnopharmacology
I P Kaĭdashev, L H Savchenko, E I Kaĭdasheva, N L Kutsenko, L O Kutsenko, I L Solokhina, T V Mamontova
We have studied efficiency of a complex therapy with metformin and ramipril combination (1000 mg and 5 mg per day) respectively in patients with metabolic syndrome (MS). The group of patients with MS which answered the basic criteria IDF (2005) was determined. Carbohydrate and Lipidic metabolism were studied. Patients were characterized with raised weight index (WI), arterial hypertension, increased concentration of triglycerides in blood serum, of glucose, of HbAlc level and S-peptide, and also high level of endotelin (1-38) and CD32+CD40+circulating particles of endothelium...
October 2010: Likars'ka Sprava
Dragana Radović Janosević, Vekoslav Lilić, Hakija Basić, Aleksandra Tubić Pavlović, Milan Stefanović, Jelena Milosević
BACKGROUND/AIM: A repeated or habitual miscarriage (PSP) is defined as three or more consecutive losses of pregnancy. In the first three months of pregnancy, habitual miscarriages occur in about 1% of pregnant women, out of which 50% are of an unknown etiology. It is believed that among them, the greatest number is the consequence of an inadequate alloimmune response of a women to the pregnancy. The endocrine and immune systems are in a close interaction during the implantation and maintaining of pregnancy...
January 2011: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Beata Kieć-Wilk, Tomasz Klupa, Aldona Dembińska-Kieć
Non-alcoholic fatty liver disease (NAFLD) is a complex of a wide spectrum of liver pathology--from steatosis alone, to cirrhosis and liver cancer. The pathogenic concept of NAFLD covers overnutrition with fatty acids, underactivity. Insulin resistance is believed to play the main role in this process. NAFLD is mostly related to visceral adiposity, metabolic syndrome and type 2 diabetes melitus. The presented work is a review of in vitro and in vivo modern studies, as well as clinical observations on molecular mechanisms leading to development and progress of NAFLD...
2010: Przegla̧d Lekarski
M Kucera, S Oravec, I Ocadlík
There are accepted the lipid levels goals in all world, which are needed to achievement in primary and secondary prevention. Despite efficacy of current standards of care (including achievement of LDL-C, blood pressure and blood sugar goals), patients with atherogenic dyslipidemia (DLP) (high TG levels, low HDL-C, high apolipoprotein B and small dense LDL-particles), which is common in patients with diabetes melitus (DM), metabolic syndrome or cardiovascular diseases (KVD), remain exposed to a high residual risk of major cardiovascular events and microvascular complications...
August 2010: Vnitr̆ní Lékar̆ství
Sasa Missoni
The island of Vis belongs to middle Dalmatian group of islands with caracteristics Mediterranean climate. The assumption was that the dominant diet of the inhabitants is also Mediterranean. Such diet is considered to be one of the best for the prevention of many complex and chronic diseases, as confirmed by numerous studies in different parts of the World. This study showed a shift in dietary habits in the direction of a more globalized diet. Such sudden shift may prove to be an important trigger for the development of complex diseases such as diabetes melitus type 2, cardiovascular diseases, gout, as well as certain types of cancer...
December 2009: Collegium Antropologicum
Evros K Vassiliou, Andres Gonzalez, Carlos Garcia, James H Tadros, Goutam Chakraborty, Jeffrey H Toney
BACKGROUND: Chronic inflammation is a key player in pathogenesis. The inflammatory cytokine, tumor necrosis factor-alpha is a well known inflammatory protein, and has been a therapeutic target for the treatment of diseases such as Rheumatoid Arthritis and Crohn's Disease. Obesity is a well known risk factor for developing non-insulin dependent diabetes melitus. Adipose tissue has been shown to produce tumor necrosis factor-alpha, which has the ability to reduce insulin secretion and induce insulin resistance...
June 26, 2009: Lipids in Health and Disease
Yukio Ando
Transthyretin (TTR) was previously called prealbumin because the band it formed on agarose gel electrophoresis at pH 8.6 was at the prealbumin position. However, it has been well documented that TTR of rodents does not show a prealbumin position on electrophoresis. Now, its name describes its function, binding to retinol binding protein (RBP) and T4. The serum concentration of the protein is 20-40 mg/dl, and TTR forms a tetramer. The plasma half life of the protein is 1.9 days. TTR is synthesized by the liver, retina, pancreas, and choroid plexus...
March 2009: Rinsho Byori. the Japanese Journal of Clinical Pathology
Joanna Raszeja-Wyszomirska, Małgorzata Lawniczak, Wojciech Marlicz, Joanna Miezyńska-Kurtycz, Piotr Milkiewicz
Non-alcoholic fatty liver disease (NAFLD) covers a wide spectrum of liver pathology--from steatosis alone, through the necroinflammatory disorder of non-alcoholic steatohepatitis (NASH) to cirrhosis and liver cancer. NAFLD/NASH is mostly related with visceral adiposity, obesity, type 2 diabetes melitus (DM t.2) and metabolic syndrome. Pathogenetic concepts of NAFLD include overnutrition and underactivity, insulin resistance (IR) and genetic factor. The prevalence of NAFLD has been estimated to be 17-33% in some countries, NASH may be present in about 1/3 of such cases, while 20-25% of NASH cases could progress to cirrhosis...
June 2008: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Brian G DeRubertis, Angela Vouyouka, Soo J Rhee, Joseph Califano, John Karwowski, Niren Angle, Peter L Faries, K Craig Kent
OBJECTIVES: Experience with open surgical bypass suggests similar overall outcomes in women compared with men, but significantly increased risk of wound complications. Percutaneous treatment of lower extremity occlusive disease is therefore an attractive alternative in women, although it is not clear whether there is a difference in outcomes between women and men treated with this technique. We sought to determine the results and predictors of failure in women treated by percutaneous intervention...
July 2008: Journal of Vascular Surgery
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