keyword
https://read.qxmd.com/read/38503191/androgen-regulation-of-behavioral-stress-responses-and-the-hypothalamic-pituitary-adrenal-axis
#1
JOURNAL ARTICLE
Damian G Zuloaga, Jennifer J Lafrican, Kristen L Zuloaga
Testosterone is a powerful steroid hormone that can impact the brain and behavior in various ways, including regulating behavioral and neuroendocrine (hypothalamic-pituitary-adrenal (HPA) axis) stress responses. Early in life androgens can act to alter development of brain regions associated with stress regulation, which ultimately impacts the display of stress responses later in life. Adult circulating androgens can also influence the expression of distinct genes and proteins that regulate stress responses...
March 18, 2024: Hormones and Behavior
https://read.qxmd.com/read/38493018/effects-of-age-dependent-hormonal-changes-and-estrogen-supplementation-on-voice-in-girls-with-anorexia-nervosa-preliminary-report
#2
JOURNAL ARTICLE
Barbara Maciejewska, Zofia Maciejewska-Szaniec, Bogna Małaczyńska, Aleksandra Rajewska-Rager, Michał Michalak, Piotr Iwanowski
INTRODUCTION: Human development includes lots of physical and emotional changes. The human voice depends on age. Voice production is a complex physiological and acoustic phenomenon that depends on many factors such as structure, hormone level, degree of fatigue or nutrition and hydration of the body, systemic diseases, and emotional state. All these factors can be present in anorexia nervosa (AN), such as excessive weight loss, generated hydro-electrolytic changes, nutritional deficiencies, hormonal disturbances in the function of the hypothalamic-pituitary-adrenal axis, the hypothalamic-pituitary-thyroid axis, the hypothalamic-pituitary-ovarian axis, and emotional distress...
March 15, 2024: Journal of Voice
https://read.qxmd.com/read/38485341/activation-of-%C3%AF-1-receptor-mitigates-estrogen-withdrawal-induced-anxiety-depressive-like-behavior-in-mice-via-restoration-of-gaba-glutamate-signaling-and-neuroplasticity-in-the-hippocampus
#3
JOURNAL ARTICLE
Peng Ren, Jing-Ya Wang, Hong-Lei Chen, Yue Wang, Lin-Yu Cui, Jing-Yao Duan, Wen-Zhi Guo, Yong-Qi Zhao, Yun-Feng Li
Postpartum depression (PPD) is a significant contributor to maternal morbidity and mortality. The Sigma-1 (σ-1) receptor has received increasing attention in recent years because of its ability to link different signaling systems and exert its function in the brain through chaperone actions, especially in neuropsychiatric disorders. YL-0919, a novel σ-1 receptor agonist developed by our institute, has shown antidepressive and anxiolytic effects in a variety of animal models, but effects on PPD have not been revealed...
April 2024: Journal of Pharmacological Sciences
https://read.qxmd.com/read/38449668/processed-polygonatum-cyrtonema-hua-attenuates-postpartum-depression-in-rat-model-by-regulating-monoamines-and-hormones
#4
JOURNAL ARTICLE
Xiao-Hong Zhu, Jia-Li Zhang, De-Hua Li, Zhong-Qiang Wang, Yan-Ku Liu, Jing-Xian Fan, Shang-Ren Jiang, Xin-Ran Li, Xian-Yuan He
BACKGROUND: Polygonatum cyrtonema Hua is a traditional Chinese medicinal food herb which can regulate the liver and Qi, nourish the heart and blood, moisten the lungs and nourish the kidneys with the potential to treat emotional diseases. However, few studies have explored the effects of Polygonatum cyrtonema Hua on postpartum depression. Therefore, we investigated whether processed Polygonatum cyrtonema Hua could improve postpartum depression in rat models by regulating monoamines and hormones...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38397404/exploratory-review-of-the-takotsubo-syndrome-and-the-possible-role-of-the-psychosocial-stress-response-and-inflammaging
#5
REVIEW
Niklas Frank, Martin J Herrmann, Martin Lauer, Carola Y Förster
Takotsubo syndrome (TTS) is a cardiomyopathy that clinically presents as a transient and reversible left ventricular wall motion abnormality (LVWMA). Recovery can occur spontaneously within hours or weeks. Studies have shown that it mainly affects older people. In particular, there is a higher prevalence in postmenopausal women. Physical and emotional stress factors are widely discussed and generally recognized triggers. In addition, the hypothalamic-pituitary-adrenal (HPA) axis and the associated glucocorticoid-dependent negative feedback play an important role in the resulting immune response...
January 31, 2024: Biomolecules
https://read.qxmd.com/read/38344954/sex-differences-in-androgen-receptor-estrogen-receptor-alpha-and-c-fos-co-expression-with-corticotropin-releasing-factor-expressing-neurons-in-restrained-adult-mice
#6
JOURNAL ARTICLE
Krystyna A Rybka, Jennifer J Lafrican, Zachary J Rosinger, Deborah O Ariyibi, Mecca R Brooks, Jason S Jacobskind, Damian G Zuloaga
Gonadal hormone actions through androgen receptor (AR) and estrogen receptor alpha (ERα) regulate sex differences in hypothalamic-pituitary-adrenal (HPA) axis responsivity and stress-related behaviors. Here we tested whether corticotropin releasing factor (CRF) expressing neurons, which are widely known to regulate neuroendocrine and behavioral stress responses, co-express AR and ERα as a potential mechanism for gonadal hormone regulation of these responses. Using Crh-IRES-Cre::Ai9 reporter mice we report high co-localization of AR in CRF neurons within the medial preoptic area (MPOA), bed nucleus of the stria terminalis (BST), medial amygdala (MeA), and ventromedial hypothalamus (VMH), moderate levels within the central amygdala (CeA) and low levels in the paraventricular hypothalamus (PVN)...
November 2023: Hormones and Behavior
https://read.qxmd.com/read/38309292/role-of-estrogen-in-treatment-of-female-depression
#7
REVIEW
Qihan Sun, Guangquan Li, Fangyi Zhao, Mengmeng Dong, Wei Xie, Qianqian Liu, Wei Yang, Ranji Cui
Depression is a neurological disorder that profoundly affects human physical and mental health, resulting in various changes in the central nervous system. Despite several prominent hypotheses, such as the monoaminergic theory, hypothalamic-pituitary-adrenal (HPA) axis theory, neuroinflammation, and neuroplasticity, the current understanding of depression's pathogenesis remains incomplete. Importantly, depression is a gender-dimorphic disorder, with women exhibiting higher incidence rates than men. Given estrogen's pivotal role in the menstrual cycle, it is reasonable to postulate that its fluctuating levels could contribute to the pathogenesis of depression...
February 2, 2024: Aging
https://read.qxmd.com/read/38200690/early-corticosterone-increases-vocal-complexity-in-a-wild-parrot-an-organizational-role-of-the-hypothalamic-pituitary-adrenal-axis-in-vocal-learning
#8
JOURNAL ARTICLE
Celia R McLean, Astolfo Mata, Richard J Kline, Karl S Berg
The neuroendocrinology of vocal learning is exceptionally well known in passerine songbirds. Despite huge life history, genetic and ecological variation across passerines, song learning tends to occur as a result of rises in gonadal and non-gonadal sex steroids that shape telencephalic vocal control circuits and song. Parrots are closely related but independently evolved different cerebral circuits for vocal repertoire acquisition in both sexes that serve a broader suite of social functions and do not appear to be shaped by early androgens or estrogens; instead, parrots begin a plastic phase in vocal development at an earlier life history stage that favors the growth, maturation, and survival functions of corticosteroids...
January 10, 2024: Journal of Neuroendocrinology
https://read.qxmd.com/read/38187458/copper-chaperone-for-superoxide-dismutase-subtypes-as-a-prognostic-marker-in-luminal-b-breast-cancer
#9
JOURNAL ARTICLE
Yanping Li, Wenfei Du, Rui Yang, Xiaonan Wei, Haibin Li, Xiaoyuan Zhang
BACKGROUND: Copper chaperone for superoxide dismutase ( CCS ) is an essential component of the oxidation-reduction system. In breast cancer cells, CCS expression is highly up-regulated, which contributes to cellular proliferation and migration. Breast cancer is a multifaceted disease with different tumor prognoses and responses to clinical treatments, which may be associated with multiple molecular subtypes of CCS . METHODS: The CCS expression patterns in breast cancer were investigated by TNMplot, cBioPortal, and HPA network database...
2024: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/38048875/global-cerebral-ischemia-in-adult-female-rats-interrupts-estrous-cyclicity-and-induces-lasting-changes-in-hypothalamic-pituitary-gonadal-axis-signaling-peptides
#10
JOURNAL ARTICLE
Marilou Poitras, Alexandre Morin, George E Bentley, Hélène Plamondon
Persistent post-ischemic alterations to the hypothalamic-pituitary-adrenal (HPA) axis occur following global cerebral ischemia (GCI) in rodents. However, similar effects on hypothalamic-pituitary-gonadal (HPG) axis activation remain to be determined. Therefore, this study evaluated the effects of GCI in adult female rats (via four-vessel occlusion) on the regularity of the estrous cycle for 24-days post ischemia. A second objective aimed to assess persistent alterations of HPG axis activation through determination of the expression of estrogen receptor alpha (ERα), kisspeptin (Kiss1), and gonadotropin-inhibitory hormone (GnIH/RFamide-related peptide; RFRP3) in the medial preoptic area (POA), arcuate nucleus (ARC), dorsomedial nucleus (DMH) of the hypothalamus, and CA1 of the hippocampus 25 days post ischemia...
December 2, 2023: Neuroscience Letters
https://read.qxmd.com/read/37985782/stemness-signature-and-targeted-therapeutic-drugs-identification-for-triple-negative-breast-cancer
#11
JOURNAL ARTICLE
Samina Gul, Jianyu Pang, Hongjun Yuan, Yongzhi Chen, Qian Yu, Hui Wang, Wenru Tang
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and carries the worst prognosis, characterized by the lack of progesterone, estrogen, and HER2 gene expression. This study aimed to analyze cancer stemness-related gene signature to determine patients' risk stratification and prognosis feature with TNBC. Here one-class logistic regression (OCLR) algorithm was applied to compute the stemness index of TNBC patients. Cox and LASSO regression analysis was performed on stemness-index related genes to establish 16 genes-based prognostic signature, and their predictive performance was verified in TCGA and METABERIC merged data cohort...
November 20, 2023: Scientific Data
https://read.qxmd.com/read/37947791/cancer-related-fatigue-and-circulating-biomarkers-in-breast-cancer-survivors
#12
JOURNAL ARTICLE
David García-González, María Romero-Elías, Alejandro Álvarez-Bustos, Silvia Rosado-García, Antonio J Sánchez-López, Blanca Cantos, Constanza Maximiano, Miriam Méndez, Marta Méndez-Otero, Héctor Cebolla, Jesús García-Foncillas, Ana Ruiz-Casado
PURPOSE: Cancer-related fatigue (CRF) is the most common and disruptive symptom experienced by cancer survivors and because of its frequency and severity is especially worrisome in breast cancer survivors (BCS). Despite a great deal of research, the mechanisms underlying CRF have not been determined. The present study aims to describe associations between CRF in BCS and different blood biomarkers. METHODS: A descriptive and cross-sectional study was conducted. A set of biomarkers assessing inflammation were measured in BCS: C-reactive protein (CRP), neutrophil-lymphocyte ratio (NLR), IL-1β, IL-6, IL-8, IL-10, tumor necrosis factor (TNF); HPA axis dysfunction (cortisol), autonomic dysfunction (noradrenaline); oxidative stress (8-OH deoxyguanosine); insulin resistance markers (insulin, IGF-I, IGFBP3) and sexual hormones (estrogens, progesterone, testosterone)...
November 10, 2023: Biological Research for Nursing
https://read.qxmd.com/read/37855285/sex-differences-in-stress-response-classical-mechanisms-and-beyond
#13
JOURNAL ARTICLE
Georgia E Hodes, Debra Bangasser, Ioannis Sotiropoulos, Nikolaos Kokras, Christina Dalla
Neuropsychiatric disorders, which are associated with stress hormone dysregulation, occur at different rates in men and women. Moreover, nowadays, preclinical and clinical evidence demonstrates that sex and gender can lead to differences in stress responses that predispose males and females to different expressions of similar pathologies. In this curated review, we focus on what is known about sex differences in classic mechanisms of stress response, such as glucocorticoid hormones and corticotrophin-releasing factor (CRF), which are components of the hypothalamicpituitary- adrenal (HPA) axis...
October 5, 2023: Current Neuropharmacology
https://read.qxmd.com/read/37781188/the-role-of-the-oxytocin-system-in-the-resilience-of-patients-with-breast-cancer
#14
REVIEW
Shaochun Liu, Runze Huang, Anlong Li, Sheng Yu, Senbang Yao, Jian Xu, Lingxue Tang, Wen Li, Chen Gan, Huaidong Cheng
Breast cancer is a grave traumatic experience that can profoundly compromise patients' psychological resilience, impacting their overall quality of life. The oxytocin system represents one of the essential neurobiological bases of psychological resilience and plays a critical role in regulating resilience in response to social or traumatic events during adulthood. Oxytocin, through its direct interaction with peripheral or central oxytocin receptors, has been found to have a significant impact on regulating social behavior...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37748275/sex-specific-behavioral-and-physiological-changes-during-single-parenting-in-a-biparental-species-columba-livia
#15
JOURNAL ARTICLE
April M Booth, Rechelle Viernes, Victoria S Farrar, Laura Flores, Suzanne H Austin, Rebecca M Calisi
Many species exhibit biparental care to maximize fitness. When a partner is lost, the surviving partner may alter their behavior to compensate offspring. Whether both sexes use the same physiological mechanisms to manifest their change in behavior remains elusive. We investigated behaviors and mechanisms associated with the alteration of parental care post-partner removal in a biparental avian species, the rock dove (Columba livia). We hypothesized that rock dove single parents experience sex-biased changes in neural genomic transcription and reproductive behaviors, and these changes are related to chick development...
September 23, 2023: Hormones and Behavior
https://read.qxmd.com/read/37704445/prophylactic-effects-of-hemp-seed-oil-on-perimenopausal-depression-a-role-of-hpa-axis
#16
JOURNAL ARTICLE
Jiao Ma, Chen-Yang Guo, Han-Bing Li, Su-Hui Wu, Gen-Lin Li
Hemp seed, the dried fruit of Cannabis sativa L. (Moraceae), has been extensively documented as a folk source of food due to its nutritional and functional value. This study evaluated the antidepressant effect of hemp seed oil (HSO) during its estrogen-like effect in Perimenopausal depression (PMD) rats induced by ovariectomy combined with chronic unpredictable mild stress (OVX-CUMS). Female SD rats (SPF, 10 weeks, sham operated group, ovariectomy (OVX) model group, ovariectomy - chronic unpredictable mild stress (OVX-CUMS) group, HSO + OVX-CUMS group, fluoxetine (FLU) + OVX-CUMS group, n=8) were subjected to treatment with HSO (4...
September 12, 2023: Journal of Oleo Science
https://read.qxmd.com/read/37586098/social-isolation-and-breast-cancer
#17
JOURNAL ARTICLE
Leena Hilakivi-Clarke, Fabia de Oliveira Andrade
Although the role of life-stressors in breast cancer remains unclear, social isolation is consistently associated with increased breast cancer risk and mortality. Social isolation can be defined as loneliness or an absence of perceived social connections. In female mice and rats, social isolation is mimicked by housing animals one per cage. Social isolation causes many biological changes, of which an increase in inflammatory markers and disruptions in mitochondrial and cellular metabolism are commonly reported...
August 17, 2023: Endocrinology
https://read.qxmd.com/read/37511910/comparative-studies-on-the-anti-inflammatory-and-apoptotic-activities-of-four-greek-essential-oils-involvement-in-the-regulation-of-nf-%C3%AE%C2%BA%C3%AE-and-steroid-receptor-signaling
#18
JOURNAL ARTICLE
Achilleas Georgantopoulos, Athanasios Vougioukas, Foteini D Kalousi, Ioannis Tsialtas, Anna-Maria G Psarra
Essential oils (EOs) are well-known for their anti-fungal, anti-microbial, anti-inflammatory and relaxing activities. Steroid hormones, especially glucocorticoids, are also well-known for their anti-inflammatory activities and control of the hypothalamus-pituitary-adrenal (HPA) axis and glucose homeostasis. The biological activities of glucocorticoids render them the most widely prescribed anti-inflammatory drugs, despite their adverse side effects. In this study, comparative studies of the anti-inflammatory activities and interference with glucocorticoids receptor (GR) and estrogen receptor (ER) signaling of EOs from Greek Oregano, Melissa officinalis , Lavender and from the Chios Mastic, produced from the Greek endemic mastic tree, were performed in Human Embryonic Kidney 293 (HEK-293) cells...
July 10, 2023: Life
https://read.qxmd.com/read/37452646/sex-and-stress-hormone-dysregulation-as-clinical-manifestations-of-hypothalamic-function-in-migraine-disorder-a-meta-analysis
#19
REVIEW
Erin L Beech, Nina Riddell, Melanie J Murphy, Sheila G Crewther
Migraine is a leading cause of disability in young adults. It occurs more frequently in females, often comorbidly with stress disorders, suggesting an association with hypothalamic sex and stress hormonal function and a likely interaction with autonomic nervous system activation. Thus, this study aimed to meta-analyse current literature pertaining to female and male sex hormones (estrogen, progesterone and testosterone concentration), hypothalamic-pituitary-adrenal axis (HPA axis) cortisol responses and heart rate variability (HRV) in migraineurs and controls aged 13-65 years...
August 2023: European Journal of Neuroscience
https://read.qxmd.com/read/37357219/-further-progress-of-the-etiology-diagnosis-and-treatment-of-peripheral-precocious-puberty
#20
JOURNAL ARTICLE
J Zhang, N J Wan
Peripheral precocious puberty(PPP),also known as puberty independent from hypothalamic-pituitary axis activation,is stimulated by hormones from other sources, with only partial sexual characteristics development but without mature sexual function. The secondary sexual characteristics development occurs before 7.5 years of age in girls and before 9 years of age in boys. Clinical manifestations are diverse, and PPP has varied etiology including congenital adrenal hyperplasia, McCune-Albright syndrome, ovarian cyst, adrenal tumor, ovarian tumor, testicular tumor, human chorionic gonadotropin producing tumor, familial male precocious puberty, aromatase excess syndrome, and environmental estrogen...
June 6, 2023: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
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