keyword
https://read.qxmd.com/read/38542762/glutathione-supplementation-prevents-neonatal-parenteral-nutrition-induced-short-and-long-term-epigenetic-and-transcriptional-disruptions-of-hepatic-h-2-o-2-metabolism-in-guinea-pigs
#1
JOURNAL ARTICLE
Angela Mungala Lengo, Ibrahim Mohamed, Jean-Claude Lavoie
The parenteral nutrition (PN) received by premature newborns is contaminated with peroxides that induce global DNA hypermethylation via oxidative stress. Exposure to peroxides could be an important factor in the induction of chronic diseases such as those observed in adults who were born preterm. As endogenous H2 O2 is a major regulator of glucose-lipid metabolism, our hypothesis was that early exposure to PN induces permanent epigenetic changes in H2 O2 metabolism. Three-day-old guinea pigs were fed orally (ON), PN or glutathione-enriched PN (PN+GSSG)...
March 15, 2024: Nutrients
https://read.qxmd.com/read/38540788/ammoniagenic-action-of-valproate-without-signs-of-hepatic-dysfunction-in-rats-possible-causes-and-supporting-evidence
#2
JOURNAL ARTICLE
Gubidat Alilova, Lyudmila Tikhonova, Carmina Montoliu, Elena Kosenko
(1) Background: Valproic acid (VPA) is one of the frequently prescribed antiepileptic drugs and is generally considered well tolerated. However, VPA neurologic adverse effects in the absence of liver failure are fairly common, suggesting that in the mechanism for the development of VPA-induced encephalopathy, much more is involved than merely the exposure to hyperammonemia (HA) caused by liver insufficiency to perform detoxification. Taking into account the importance of the relationship between an impaired brain energy metabolism and elevated ammonia production, and based on the ability of VPA to interfere with neuronal oxidative pathways, the current study intended to investigate a potential regional ammoniagenic effect of VPA on rats' brains by determining activities of the enzymes responsible for ammonia production and neutralization...
March 19, 2024: Biomolecules
https://read.qxmd.com/read/38530625/acute-high-output-heart-failure-with-pulmonary-hypertension-and-severe-liver-injury-caused-by-amlodipine-poisoning-a-case-report
#3
JOURNAL ARTICLE
Chenlong Wang, Qingcheng Zhu, Dingyu Tan, Joseph Walline, Yachao Wang
Acute high-output heart failure (HOHF) with pulmonary hypertension and liver injury caused by amlodipine poisoning is very rare. We report a 52-year-old woman who suffered from severe shock after an overdose of amlodipine. Hemodynamic monitoring showed that while her left ventricular systolic function and cardiac output were elevated, her systemic vascular resistance decreased significantly. At the same time, the size of her right heart, her central venous pressure, and the oxygen saturation of her central venous circulation all increased abnormally...
March 26, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38528259/establishment-and-characterization-of-cytochrome-p450-1a1-crispr-cas9-knockout-bovine-foetal-hepatocyte-cell-line-bfh12
#4
JOURNAL ARTICLE
Silvia Iori, Caterina D'Onofrio, Nihay Laham-Karam, Isidore Mushimiyimana, Lorena Lucatello, Rosa Maria Lopparelli, Maria Elena Gelain, Francesca Capolongo, Marianna Pauletto, Mauro Dacasto, Mery Giantin
The cytochrome P450 1A (CYP1A) subfamily of xenobiotic metabolizing enzymes (XMEs) consists of two different isoforms, namely CYP1A1 and CYP1A2, which are highly conserved among species. These two isoenzymes are involved in the biotransformation of many endogenous compounds as well as in the bioactivation of several xenobiotics into carcinogenic derivatives, thereby increasing the risk of tumour development. Cattle (Bos taurus) are one of the most important food-producing animal species, being a significant source of nutrition worldwide...
March 26, 2024: Cell Biology and Toxicology
https://read.qxmd.com/read/38523677/diverse-functions-of-sox9-in-liver-development-and-homeostasis-and-hepatobiliary-diseases
#5
REVIEW
Taiyu Shang, Tianyi Jiang, Xiaowen Cui, Yufei Pan, Xiaofan Feng, Liwei Dong, Hongyang Wang
The liver is the central organ for digestion and detoxification and has unique metabolic and regenerative capacities. The hepatobiliary system originates from the foregut endoderm, in which cells undergo multiple events of cell proliferation, migration, and differentiation to form the liver parenchyma and ductal system under the hierarchical regulation of transcription factors. Studies on liver development and diseases have revealed that SRY-related high-mobility group box 9 (SOX9) plays an important role in liver embryogenesis and the progression of hepatobiliary diseases...
July 2024: Genes & Diseases
https://read.qxmd.com/read/38522586/consumption-of-toxic-benthic-cyanobacteria-by-two-common-demersal-fish-growth-antioxidant-and-liver-histopathology-responses
#6
JOURNAL ARTICLE
Hongmin Li, Yuan Yuan, Huiting Yang, Xinyue Xu, Wenxia Wang, Yanfeng Chen, Changlin Kan, Hengji Zhufu, Chen Gong
Benthic freshwater cyanobacteria have the potential to produce toxins. Compared with more extensively studied plankton species, little is known about the impact of harmful benthic cyanobacteria on aquatic organisms. As demersal fish are usually in direct contact with benthic cyanobacteria, it is important to understand their interactive effects. This study investigated the physio-chemical responses of two demersal fish (Xenocypris davidi and Crucian carp) after exposure to benthic Oscillatoria (producing cylindrospermopsin, 2 × 106  cells/mL) for 7 days...
March 22, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38516747/protective-effect-of-black-seed-and-lettuce-oils-against-paracetamol-induced-hepatotoxicity-in-rats
#7
JOURNAL ARTICLE
Elsayed Hamed Ali Bakr, Areej Abdulhamid Hamdan Almuraee
<b>Background and Objective:</b> The liver is one of the organs that play an essential role in the human body, including supporting metabolism, immune functions, digestive system, detoxification, storage of vitamins and other functions. This investigation aimed to study the protective effects of black seed and lettuce oil against hepatotoxicity as induced by paracetamol in experimental rats. <b>Materials and Methods:</b> Twenty male Sprague-Dawley albino rats weighing 150±5 g were divided randomly into four groups (5 rats each) and distributed as follows; 1st group was controlled negative (C -ve group), 2nd group controlled positive (orally administered with 500 mg/kg b...
January 2024: Pakistan Journal of Biological Sciences: PJBS
https://read.qxmd.com/read/38506165/describing-the-ligandin-properties-of-plasmodium-falciparum-and-vivax-glutathione-transferase-towards-bromosulfophthalein-from-empirical-and-computational-modelling-viewpoints
#8
JOURNAL ARTICLE
Olalekan Onisuru, Ikechukwu Achilonu
Research has spotlighted glutathione transferase (GST) as a promising target for antimalarial drug development due to its pivotal role in cellular processes, including metabolizing toxins and managing oxidative stress. This interest arises from GST's potential to combat multidrug resistance in existing antimalarial drugs. Plasmodium falciparum GST ( Pf GST) and Plasmodium vivax GST ( Pv GST) are key targets; inhibiting them not only disrupt detoxification but also reduce their antioxidant capacity, a critical feature for potent antimalarials...
March 20, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38499550/in-vitro-and-in-vivo-investigation-of-a-thyroid-hormone-system-specific-interaction-with-triazoles
#9
JOURNAL ARTICLE
Asya Kadic, Patricia Oles, Benjamin Christian Fischer, Anne Elisabeth Reetz, Boubacar Sidiki Sylla, Katreece Feiertag, Vera Ritz, Tanja Heise, Philip Marx-Stoelting, Tewes Tralau, Kostja Renko, Marize de Lourdes Marzo Solano
Alterations in thyroid hormones (TH) and thyroid-stimulating hormone levels are frequently found following exposure to chemicals of concern. Dysregulation of TH levels can severely perturb physiological growth, metabolism, differentiation, homeostasis in the adult and developmental processes in utero. A frequently identified mode of action for this interaction is the induction of hepatic detoxification mechanisms (e.g. SULTs and UGTs), which lead to TH conjugation and elimination and therefore interfere with hormonal homeostasis, fulfilling the endocrine disruptors (EDs) definition...
March 18, 2024: Scientific Reports
https://read.qxmd.com/read/38499104/organ-specific-biotransformation-in-salmonids-insight-into-intrinsic-enzyme-activity-and-biotransformation-of-three-micropollutants
#10
JOURNAL ARTICLE
Marco E Franco, René Schönenberger, Juliane Hollender, Kristin Schirmer
Aquatic ecosystems continue to be threatened by chemical pollution. To what extent organisms are able to cope with chemical exposure depends on their ability to display mechanisms of defense across different organs. Among these mechanisms, biotransformation processes represent key physiological responses that facilitate detoxification and reduce the bioaccumulation potential of chemicals. Biotransformation does not only depend on the ability of different organs to display biotransformation enzymes but also on the affinity of chemicals towards these enzymes...
March 16, 2024: Science of the Total Environment
https://read.qxmd.com/read/38475733/the-micro-743a-3p-gstm1-pathway-is-an-endogenous-protective-mechanism-against-alcohol-related-liver-disease-in-mice
#11
JOURNAL ARTICLE
Tiantian Xu, Yan Pan, Qinchao Ding, Feiwei Cao, Kaixin Chang, Jiannan Qiu, Hui Zhuge, Liuyi Hao, Haibin Wei, Caijuan Si, Xiaobing Dou, Songtao Li
BACKGROUND AND AIMS: Epidemiological evidence suggests that the phenotype of glutathione S-transferase mu 1 (GSTM1), a hepatic high-expressed phase II detoxification enzyme, is closely associated with the incidence of alcohol-related liver disease (ALD). However, whether and how hepatic GSTM1 determines the development of ALD is largely unclear. This study was designed to elucidate the role and potential mechanism(s) of hepatic GSTM1 in the pathological process of ALD. METHODS: GSTM1 was detected in the liver of various ALD mice models and cultured hepatocytes...
March 12, 2024: Cellular & Molecular Biology Letters
https://read.qxmd.com/read/38462180/oxidative-stress-and-neurotoxicity-induced-by-exposure-to-settleable-atmospheric-particulate-matter-in-bullfrog-tadpoles-aquarana-catesbeiana-shaw-1802
#12
JOURNAL ARTICLE
Isabela Ferreira Fernandes, Gabriel Hiroshi Fujiwara, Heidi Samantha Moraes Utsunomiya, Iara Costa Souza, Diana Amaral Monteiro, Magdalena Victoria Monferrán, Daniel Alberto Wunderlin, Marisa Narciso Fernandes, Cleoni Dos Santos Carvalho
Bullfrog tadpoles, Aquarana catesbeiana, were exposed to settleable particulate matter (SePM), (1 g L-1 , 96 h) and their organs were collected for analysis of metal/metalloid, oxidative stress and neurotoxicity in liver, muscle, kidney and brain. The SePM water of the exposed groups contained 18 of the 28 metals/metalloids detected in ambient particulate matter (APM). Fe56 and Al were those that presented the highest concentrations, Cr, Mn, Pb and Cu increased from 10 to 20 times and Ti, V, Sr, Rb, Cd, Sn and Ni increased from 1 to 3 times compared to the control...
March 8, 2024: Chemosphere
https://read.qxmd.com/read/38448046/physiologically-based-pharmacokinetic-modeling-for-confirming-the-role-of-cyp3a1-2-and-p-glycoprotein-in-detoxification-mechanism-between-glycyrrhizic-acid-and-aconitine-in-rats
#13
JOURNAL ARTICLE
Jingyi Jin, Xiaoqing Xu, Fengling Li, Fengyi Weng, Bin Zou, Yue Li, Jing Zhao, Shuang Zhang, Dongming Yan, Furong Qiu
Fuzi, an effective common herb, is often combined with Gancao to treat disease in clinical practice with enhancing its efficacy and alleviating its toxicity. The major toxic and bioactive compounds in Fuzi and Gancao are aconitine (AC) and glycyrrhizic acid (GL), respectively. This study aims to elucidate detoxification mechanism between AC and GL from pharmacokinetic perspective using physiologically based pharmacokinetic (PBPK) model. In vitro experiments exhibited that AC was mainly metabolized by CYP3A1/2 in rat liver microsomes and transported by P-glycoprotein (P-gp) in Caco-2 cells...
March 6, 2024: Journal of Applied Toxicology: JAT
https://read.qxmd.com/read/38446589/targeted-detoxification-of-aflatoxin-b-1-in-edible-oil-by-an-enzyme-metal-nanoreactor
#14
JOURNAL ARTICLE
Caicai Fu, Lirui Hou, Dingchun Chen, Teng Huang, Shutao Yin, Ping Ding, Qiansui Liao, Xiaolin Huang, Yonghua Xiong, Jun Ge, Xiaoyang Li
Mycotoxin contamination is an important issue for food safety and the environment. Removing mycotoxins from food without losing nutrients and flavor components remains a challenge. In this study, a novel strategy was proposed for the targeted removal of aflatoxin B1 (AFB1 ) from peanut oil using an amphipathic enzyme-metal hybrid nanoreactor (PL-GOx-Fe3 O4 @COF) constructed with covalent organic frameworks (COFs) which can selectively adsorb AFB1 . Due to the confined space provided by COFs and the proximity effect between GOx and Fe3 O4 , the detoxification of AFB1 is limited in the nanoreactor without affecting the composition and properties of the oil...
March 6, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38436763/3%C3%AE-hydroxybufadienolides-in-bufo-gallbladders-structural-insights-and-biotransformation
#15
JOURNAL ARTICLE
Li-Jun Ruan, Zhi-Jun Song, Ren-Wang Jiang
Bufadienolides, naturally occurring steroids primarily found in toads, have garnered attention for their pharmacological properties and ecological significance. In this study, we isolated and identified 21 bufadienolides from the gallbladders of Bufo gargarizans, comprising four new compounds and 17 known ones. Notably, the predominance of 15 bufadienolides with a 3α-OH configuration in toad bile differs significantly from the 3β-OH bufadienolides found in venom secreted by toad glands. Moreover, our investigation into the biotransformation of 3β-OH and 3α-OH bufadienolides in the liver and kidney tissues of toads revealed an irreversible conversion from 3β-OH to 3α-OH bufadienolides, suggesting a crucial role in toad self-detoxification...
March 4, 2024: Natural Products and Bioprospecting
https://read.qxmd.com/read/38426941/multi-tissue-gene-expression-profiling-of-cows-with-a-genetic-predisposition-for-low-and-high-milk-urea-levels
#16
JOURNAL ARTICLE
Henry Reyer, Hanne Honerlagen, Michael Oster, Siriluck Ponsuksili, Björn Kuhla, Klaus Wimmers
Milk urea (MU) concentration is proposed as an indicator trait for breeding toward reduced nitrogen (N) emissions and leaching in dairy. We selected 20 German Holstein cows based on MU breeding values, with 10 cows each having low (LMUg) and high (HMUg) MU genetic predisposition. Using RNA-seq, we characterized these cows to unravel molecular pathways governing post-absorptive body N pools focusing on renal filtration and reabsorption of nitrogenous compounds, hepatic urea formation and mammary gland N excretion...
March 1, 2024: Animal Biotechnology
https://read.qxmd.com/read/38418503/metalloproteomic-analysis-of-liver-proteins-isolated-from-broilers-fed-with-different-sources-and-levels-of-copper-and-manganese
#17
JOURNAL ARTICLE
Renata Aparecida Martins, Andrey Sávio de Almeida Assunção, José Cavalcante Souza Vieira, Leone Campos Rocha, Priscila Michelin Groff Urayama, Marília Afonso Rabelo Buzalaf, José Roberto Sartori, Pedro de Magalhães Padilha
Supplementing minerals beyond dietary requirements can increase the risk of toxicity and mineral excretion, making the selection of more bioavailable sources crucial. Thus, this work aimed to use metalloproteomics tools to investigate possible alterations in the hepatic proteome of broilers fed with diets containing two sources (sulfate and hydroxychloride) and two levels of copper (15 and 150 ppm) and manganese (80 and 120 ppm), totaling four treatments: low Cu/Mn SO4 , high Cu/Mn SO4 , low Cu/Mn (OH)Cl and high Cu/Mn (OH)Cl...
February 28, 2024: Scientific Reports
https://read.qxmd.com/read/38411492/diagnosis-toxicological-mechanism-and-detoxification-for-hepatotoxicity-induced-by-pyrrolizidine-alkaloids-from-herbal-medicines-or-other-plants
#18
REVIEW
Zhenlin Huang, Zeqi Wu, Xinnan Gu, Lili Ji
Pyrrolizidine alkaloids (PAs) are one type of phytotoxins distributed in various plants, including many medicinal herbs. Many organs might suffer injuries from the intake of PAs, and the liver is the most susceptible one. The diagnosis, toxicological mechanism, and detoxification of PAs-induced hepatotoxicity have been studied for several decades, which is of great significance for its prevention, diagnosis, and therapy. When the liver was exposed to PAs, liver sinusoidal endothelial cells (LSECs) loss, hemorrhage, liver parenchymal cells death, nodular regeneration, Kupffer cells activation, and fibrogenesis occurred...
February 27, 2024: Critical Reviews in Toxicology
https://read.qxmd.com/read/38408868/enzymatic-defluorination-of-a-terminally-monofluorinated-pentyl-moiety-oxidative-or-hydrolytic-mechanism
#19
JOURNAL ARTICLE
Belal Haschimi, Florian Willecke, Stefan Mundinger, Wolfgang Hüttel, Henning Jessen, Michael Müller, Volker Auwärter
Fluorination of organic compounds plays an important role in the chemical and pharmaceutical industry and is often applied in order to improve physicochemical parameters or modify pharmacological properties. While oxidative and reductive defluorination have been shown to be responsible for the metabolic degradation of organofluorine compounds, the involvement of hydrolytic mechanisms catalyzed by human enzymes has not been reported so far. Here, we investigated the enzymatic defluorination of terminally monofluorinated aliphates with [1-(5-fluoropentyl)-1 H -indol-3-yl]-1-naphthalenyl-methanone (AM-2201) as a model substance...
February 26, 2024: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://read.qxmd.com/read/38403205/dimethylmonothioarsinic-acid-dmmta-v-differentially-modulates-the-expression-of-ahr-regulated-cytochrome-p450-1a-enzymes-in-vivo-and-in-vitro
#20
JOURNAL ARTICLE
Sara R El-Mahrouk, Mahmoud A El-Ghiaty, Mohammed A Alqahtani, Ayman O S El-Kadi
Dimethylmonothioarsinic acid (DMMTAV ), a pentavalent thio-arsenic derivative, has been found in bodily fluids and tissues including urine, liver, kidney homogenates, plasma, and red blood cells. Although DMMTAV is a minor metabolite in humans and animals, its substantial toxicity raises concerns about potential carcinogenic effects. This toxicity could be attributed to arsenicals' ability to regulate cytochrome P450 1A (CYP1A) enzymes, pivotal in procarcinogen activation or detoxification. The current study investigates DMMTAV 's impact on CYP1A1/2 expression, individually and in conjunction with its inducer, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)...
February 23, 2024: Toxicology Letters
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