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https://www.readbyqxmd.com/read/28526373/coffee-consumption-in-aged-mice-increases-energy-production-and-decreases-hepatic-mtor-levels
#1
Keita Takahashi, Shuichi Yanai, Kentaro Shimokado, Akihito Ishigami
OBJECTIVE: Coffee, one of the world's most consumed beverages, has many benefits. Some studies have reported the effects of coffee on aging. The aim of this study was to investigate the locomotor activity, energy metabolism, and lipid metabolism of aged (20-mo-old) mice given coffee. METHODS: Aged C57 BL/6 NCr mice were divided into three groups: controls that were not given coffee (n = 9), a group that received 0.1% caffeinated coffee (n = 9), and a group that received 0...
June 2017: Nutrition
https://www.readbyqxmd.com/read/28523599/differential-effects-of-early-life-nutrient-restriction-in-long-lived-ghr-ko-and-normal-mice
#2
Yimin Fang, Samuel McFadden, Justin Darcy, Cristal M Hill, Joshua A Huber, Steve Verhulst, John J Kopchick, Richard A Miller, Liou Y Sun, Andrzej Bartke
There is increasing evidence that growth hormone (GH) and insulin-like growth factor 1 (IGF-1) signaling (collectively referred to as somatotropic signaling) during development has a profound influence on aging and longevity. Moreover, the absence of GH action was shown to modify responses of adult mice to calorie restriction (CR) and other antiaging interventions. It was therefore of interest to determine whether GH resistance in GH receptor knockout (GHR-KO) mice would modify the effects of mild pre-weaning CR imposed by increasing the number of pups in a litter (the so-called litter crowding)...
May 18, 2017: GeroScience
https://www.readbyqxmd.com/read/28518407/nad-a-big-player-in-cardiac-and-skeletal-muscle-remodeling-and-aging
#3
REVIEW
Pankaj Chaturvedi, Suresh C Tyagi
In the past decade, NAD+ has gained importance for its beneficial effects as antioxidant and antiaging molecule. A paper in science by Zhang et al (2016) has described that NAD+ when replenished, ameliorates muscle dystrophy in mice by improving mitochondrial function. NAD+ was also demonstrated by the authors to improve the life span of mice. Cox et al (2002) demonstrated the cardiac effects of NAD+ which mitigated chronic heart failure via mitochondrial redox state mechanism. Cox et al (2002) also demonstrated that NAD+ is provided in the drinking water, it improves cardiac relaxation in volume overload model of heart failure...
May 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28512525/h2s-donor-nahs-changes-the-production-of-endogenous-h2s-and-no-in-d-galactose-induced-accelerated-ageing
#4
Wei Wu, Cui-Lan Hou, Xue-Pan Mu, Chen Sun, Yi-Chun Zhu, Ming-Jie Wang, Qian-Zhou Lv
Aims. The study was designed to explore whether hydrogen sulphide (H2S) and nitric oxide (NO) generation changed in D-galactose- (D-gal-) induced ageing, the possible effects of exogenous H2S supplementation, and related mechanisms. Results. In D-gal-induced senescent mice, both H2S and NO levels in the heart, liver, and kidney tissues were decreased significantly. A similar trend was observed in D-gal-challenged human umbilical vein endothelial cells (HUVECs). Sustained H2S donor (NaHS) treatment for 2 months elevated H2S and NO levels in these mice, and during this period, the D-gal-induced senescent phenotype was reversed...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28491095/angelica-sinensis-polysaccharide-prevents-hematopoietic-stem-cells-senescence-in-d-galactose-induced-aging-mouse-model
#5
Xinyi Mu, Yanyan Zhang, Jing Li, Jieyu Xia, Xiongbin Chen, Pengwei Jing, Xiaoying Song, Lu Wang, Yaping Wang
Age-related regression in hematopoietic stem/progenitor cells (HSC/HPCs) limits replenishment of the blood and immune system and hence contributes to hematopoietic diseases and declined immunity. In this study, we employed D-gal-induced aging mouse model and observed the antiaging effects of Angelica Sinensis Polysaccharide (ASP), a major active ingredient in dong quai (Chinese Angelica Sinensis), on the Sca-1(+) HSC/HPCs in vivo. ASP treatment prevents HSC/HPCs senescence with decreased AGEs levels in the serum, reduced SA-β-Gal positive cells, and promoted CFU-Mix formation in the D-gal administrated mouse...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28490897/glutathione-and-its-antiaging-and-antimelanogenic-effects
#6
Sinee Weschawalit, Siriwan Thongthip, Phanupong Phutrakool, Pravit Asawanonda
BACKGROUND: Previous studies showed that supplementation of reduced form of glutathione (GSH, 500 mg/d) has a skin-lightening efficacy in humans. This study was designed to evaluate the influences of both GSH and oxidized form (GSSG), at doses lower than 500 mg/d, on improving skin properties. PATIENTS AND METHODS: A randomized, double-blind, placebo-controlled, parallel, three-arm study was conducted. Healthy female subjects were equally randomized into three groups and took GSH (250 mg/d), GSSG (250 mg/d), or placebo orally for 12 weeks...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28479925/inhibition-of-cardiac-hypertrophy-effects-in-d-galactose-induced-senescent-hearts-by-alpinate-oxyphyllae-fructus-treatment
#7
Yung-Ming Chang, Hen-Hong Chang, Hung-Jen Lin, Chin-Chuan Tsai, Chuan-Te Tsai, Hsin-Nung Chang, Shu-Luan Lin, Vijaya PadmaViswanadha, Ray-Jade Chen, Chih-Yang Huang
Aging is a complex physiological phenomenon accelerated by ROS accumulation, with multisystem decline and increasing vulnerability to degenerative diseases and death. Cardiac hypertrophy is a key pathophysiological component that accompanies the aging process. Alpinate Oxyphyllae Fructus (Alpinia oxyphylla MIQ, AOF) is a traditional Chinese medicine, which provides cardioprotective activity against aging, hypertension, and cerebrovascular disorders. In this study, we found the protective effect of AOF against cardiac hypertrophy in D-galactose-induced aging rat model...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28476020/the-role-of-autophagy-in-hepatocellular-carcinoma-friend-or-foe
#8
REVIEW
Lian Liu, Jia-Zhi Liao, Xing-Xing He, Pei-Yuan Li
Autophagy is an evolutionarily conserved lysosome-dependent catabolic process which degrades cell's components in order to recycle substrates to exert optimally and adapt to tough circumstances. It is a critical cellular homeostatic mechanism with stress resistance, immunity, antiaging, and pro-tumor or anti-tumor effects. Among these, the role of autophagy in cancer is the most eye-catching that is not immutable but dynamic and highly complex. Basal autophagy acts as a tumor suppressor by maintaining genomic stability in normal cells...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28460992/chemical-constituents-and-health-effects-of-sweet-potato
#9
REVIEW
Sunan Wang, Shaoping Nie, Fan Zhu
Sweet potatoes are becoming a research focus in recent years due to their unique nutritional and functional properties. Bioactive carbohydrates, proteins, lipids, carotenoids, anthocyanins, conjugated phenolic acids, and minerals represent versatile nutrients in different parts (tubers, leaves, stems, and stalks) of sweet potato. The unique composition of sweet potato contributes to their various health benefits, such as antioxidative, hepatoprotective, antiinflammatory, antitumor, antidiabetic, antimicrobial, antiobesity, antiaging effects...
November 2016: Food Research International
https://www.readbyqxmd.com/read/28458714/antiaging-and-anxiolytic-effects-of-combinatory-formulas-based-on-four-medicinal-herbs
#10
Rui Li, Wingman Chan, Waikin Mat, Yiucheong Ho, Rigil K Yeung, Shuiying Tsang, Hong Xue
The objective of the present study was to search for medicinal-herb combinations based on Radix Bupleurum chinense DC ("B"), Rhizoma Corydalis yanhusuo WT Wang ("Y"), Caulis Polygonum multiflorum Thunb ("P"), and Flos Albizia julibrissin Durazz ("A") for antiaging, anxiolytic, and sedative effects. Application of the D-galactose induced accelerated-aging model employing male ICR mice showed that oral administration of some combinations of B, Y, P, and A significantly improved spatial memory in Y-maze test and reduced brain levels of tumor necrosis factor-α and interleukin-6 based on immunoassays and oxidative stress marker malondialdehyde, based on the thiobarbituric acid test, and the loss of whiskers, indicating antiaging and antineurodegeneration effects...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28442546/modeled-structural-basis-for-the-recognition-of-%C3%AE-2-3-sialyllactose-by-soluble-klotho
#11
Jon D Wright, Sung-Wan An, Jian Xie, Joonho Yoon, Nicole Nischan, Jennifer J Kohler, Noelynn Oliver, Carmay Lim, Chou-Long Huang
Soluble Klotho (sKlotho) is the shed ectodomain of antiaging membrane Klotho that contains 2 extracellular domains KL1 and KL2, each of which shares sequence homology to glycosyl hydrolases. sKlotho elicits pleiotropic cellular responses with a poorly understood mechanism of actions. Notably, in injury settings, sKlotho confers cardiac and renal protection by down-regulating calcium-permeable transient receptor potential canonical type isoform 6 (TRPC6) channels in cardiomyocytes and glomerular podocytes. Inhibition of PI3K-dependent exocytosis of TRPC6 is thought to be the underlying mechanism, and recent studies showed that sKlotho interacts with α2-3-sialyllactose-containing gangliosides enriched in lipid rafts to inhibit raft-dependent PI3K signaling...
April 25, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28429341/hyalone%C3%A2-in-the-treatment-of-symptomatic-hip-oa-data-from-the-antiage-register-seven-years-of-observation
#12
A Migliore, U Massafra, B Frediani, E Bizzi, E Sinelnikov Yzchaki, G Gigliucci, M Cassol, S Tormenta
OBJECTIVE: Several studies on knee osteoarthritis suggest that the intra-articular administration of hyaluronic acid products may be a relevant option in the management of patients with persistent pain. The aim of this study is to report the data of efficacy of US-guided HyalOne®/Hyalubrix® 60 injections in a large population of patients with hip osteoarthritis, repeated at least 2 times per year for up to seven years. PATIENTS AND METHODS: This is a prospective, post-marketing, cohort study...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28412336/antiageing-activities-of-water-soluble-chitosan-from-clanis-bilineata-larvae
#13
Shengjun Wu, Mingsheng Lu, Shujun Wang
Water extracts were prepared using water-soluble chitosan from Clanis bilineata larva skin. This study also investigated antioxidant and antiageing activities of water-soluble chitosan. Water-soluble chitosan of Clanis bilineata larva skin (CBLSWSC) showed considerable scavenging activities on superoxide anion and hydroxyl radicals and reducing capacity. Different doses of CBLSWSC were intragastrically administered on a d-galactose-induced-aged mouse model over a period of six weeks. Intragastric CBLSWSC administration significantly increased activities of superoxide dismutase and glutathione peroxidase and inhibited formation of malondialdehyde in brains and sera of mice in a dose-dependent manner...
April 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28389720/superoxide-dismutase-1-is-positively-selected-to-minimize-protein-aggregation-in-great-apes
#14
Pouria Dasmeh, Kasper P Kepp
Positive (adaptive) selection has recently been implied in human superoxide dismutase 1 (SOD1), a highly abundant antioxidant protein with energy signaling and antiaging functions, one of very few examples of direct selection on a human protein product (exon); the molecular drivers of this selection are unknown. We mapped 30 extant SOD1 sequences to the recently established mammalian species tree and inferred ancestors, key substitutions, and signatures of selection during the protein's evolution. We detected elevated substitution rates leading to great apes (Hominidae) at ~1 per 2 million years, significantly higher than in other primates and rodents, although these paradoxically generally evolve much faster...
April 7, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28386313/the-citrus-flavanone-naringenin-protects-myocardial-cells-against-age-associated-damage
#15
Eleonora Da Pozzo, Barbara Costa, Chiara Cavallini, Lara Testai, Alma Martelli, Vincenzo Calderone, Claudia Martini
In recent years, the health-promoting effects of the citrus flavanone naringenin have been examined. The results have provided evidence for the modulation of some key mechanisms involved in cellular damage by this compound. In particular, naringenin has been revealed to have protective properties such as an antioxidant effect in cardiometabolic disorders. Very recently, beneficial effects of naringenin have been demonstrated in old rats. Because aging has been demonstrated to be directly related to the occurrence of cardiac disorders, in the present study, the ability of naringenin to prevent cardiac cell senescence was investigated...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28359075/a-holistic-approach-to-antiaging-as-an-adjunct-to-antiaging-procedures-a-review-of-the-literature
#16
REVIEW
Sandeep S Saluja, Sabrina G Fabi
BACKGROUND: Aging is a multifactorial process and depends on both intrinsic and extrinsic factors. Procedural options for diminishing signs of intrinsic aging and cosmetic rejuvenation have expanded dramatically. However, less attention is paid to counseling patients on options for mitigating extrinsic factors related to aging. OBJECTIVE: The objective of this study was to review changes that occur with intrinsic and extrinsic aging, and provide evidence-based holistic counseling recommendations that can be used synergistically with aesthetic procedures to maximize antiaging interventions...
April 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28315683/klotho-ameliorates-cyclosporine-a-induced-nephropathy-via-pdlim2-nf-kb-p65-signaling-pathway
#17
Meihua Jin, Pengfei Lv, Guanyu Chen, Peng Wang, Zhongfu Zuo, Lili Ren, Jing Bi, Chul-Woo Yang, Xifan Mei, Donghe Han
Klotho, an antiaging protein, can extend the lifespan and modulate cellular responses to inflammation and oxidative stress which can ameliorate chronic kidney diseases (CKD). To investigate the molecular mechanism of Klotho on inflammation in cyclosporine A (CsA) induced nephropathy, the mice were transfected with adenovirus mediated Klotho gene and treated with cyclosporine A (CsA; 30 mg/kg/day) for 4 weeks. Also, primary human renal proximal tubule epithelial cells (RPTECs) were treated with soluble Klotho protein and LPS...
March 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28280523/resveratrol-attenuates-copper-induced-senescence-by-improving-cellular-proteostasis
#18
Liliana Matos, Alexandra Monteiro Gouveia, Henrique Almeida
Copper sulfate-induced premature senescence (CuSO4-SIPS) consistently mimetized molecular mechanisms of replicative senescence, particularly at the endoplasmic reticulum proteostasis level. In fact, disruption of protein homeostasis has been associated to age-related cell/tissue dysfunction and human disorders susceptibility. Resveratrol is a polyphenolic compound with proved antiaging properties under particular conditions. In this setting, we aimed to evaluate resveratrol ability to attenuate cellular senescence induction and to unravel related molecular mechanisms...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28268173/improvement-of-osteoporosis-by-lycium-chinense-administration-in-ovariectomized-mice
#19
Mi Hye Kim, Ji Eun Lee, Jae Sung Lee, Woong Mo Yang
BACKGROUND: The fruit of Lycium chinense (LC), one of the most popular natural materials, has been used to counter the effects of musculoskeletal diseases in oriental medicine. In particular, this fruit is known to have antiaging effects, which is of significant interest to the research community. The purpose of our investigation was to observe and confirm the ameliorative effect of LC on osteoporosis, which was verified in this in vivo study. METHODS: Female ICR mice aged 5 weeks were surgically ovariectomized (OVX) to induce osteoporosis...
March 3, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28260881/ginseng-berry-mediated-gold-and-silver-nanoparticle-synthesis-and-evaluation-of-their-in-vitro-antioxidant-antimicrobial-and-cytotoxicity-effects-on-human-dermal-fibroblast-and-murine-melanoma-skin-cell-lines
#20
Zuly Elizabeth Jiménez Pérez, Ramya Mathiyalagan, Josua Markus, Yeon-Ju Kim, Hyun Mi Kang, Ragavendran Abbai, Kwang Hoon Seo, Dandan Wang, Veronika Soshnikova, Deok Chun Yang
There has been a growing interest in the design of environmentally affable and biocompatible nanoparticles among scientists to find novel and safe biomaterials. Panax ginseng Meyer berries have unique phytochemical profile and exhibit beneficial pharmacological activities such as antihyperglycemic, antiobesity, antiaging, and antioxidant properties. A comprehensive study of the biologically active compounds in ginseng berry extract (GBE) and the ability of ginseng berry (GB) as novel material for the biosynthesis of gold nanoparticles (GBAuNPs) and silver nanoparticles (GBAgNPs) was conducted...
2017: International Journal of Nanomedicine
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