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https://www.readbyqxmd.com/read/28315683/klotho-ameliorates-cyclosporine-a-induced-nephropathy-via-pdlim2-nf-kb-p65-signaling-pathway
#1
Meihua Jin, Pengfei Lv, Guanyu Chen, Peng Wang, Zhongfu Zuo, Lili Ren, Jing Bi, Chul-Woo Yang, Xifan Mei, Donghe Han
Klotho, an antiaging protein, can extend the lifespan and modulate cellular responses to inflammation and oxidative stress which can ameliorate chronic kidney diseases (CKD). To investigate the molecular mechanism of Klotho on inflammation in cyclosporine A (CsA) induced nephropathy, the mice were transfected with adenovirus mediated Klotho gene and treated with cyclosporine A (CsA; 30 mg/kg/day) for 4 weeks. Also, primary human renal proximal tubule epithelial cells (RPTECs) were treated with soluble Klotho protein and LPS...
March 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28280523/resveratrol-attenuates-copper-induced-senescence-by-improving-cellular-proteostasis
#2
Liliana Matos, Alexandra Monteiro Gouveia, Henrique Almeida
Copper sulfate-induced premature senescence (CuSO4-SIPS) consistently mimetized molecular mechanisms of replicative senescence, particularly at the endoplasmic reticulum proteostasis level. In fact, disruption of protein homeostasis has been associated to age-related cell/tissue dysfunction and human disorders susceptibility. Resveratrol is a polyphenolic compound with proved antiaging properties under particular conditions. In this setting, we aimed to evaluate resveratrol ability to attenuate cellular senescence induction and to unravel related molecular mechanisms...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28268173/improvement-of-osteoporosis-by-lycium-chinense-administration-in-ovariectomized-mice
#3
Mi Hye Kim, Ji Eun Lee, Jae Sung Lee, Woong Mo Yang
BACKGROUND: The fruit of Lycium chinense (LC), one of the most popular natural materials, has been used to counter the effects of musculoskeletal diseases in oriental medicine. In particular, this fruit is known to have antiaging effects, which is of significant interest to the research community. The purpose of our investigation was to observe and confirm the ameliorative effect of LC on osteoporosis, which was verified in this in vivo study. METHODS: Female ICR mice aged 5 weeks were surgically ovariectomized (OVX) to induce osteoporosis...
March 3, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28260881/ginseng-berry-mediated-gold-and-silver-nanoparticle-synthesis-and-evaluation-of-their-in-vitro-antioxidant-antimicrobial-and-cytotoxicity-effects-on-human-dermal-fibroblast-and-murine-melanoma-skin-cell-lines
#4
Zuly Elizabeth Jiménez Pérez, Ramya Mathiyalagan, Josua Markus, Yeon-Ju Kim, Hyun Mi Kang, Ragavendran Abbai, Kwang Hoon Seo, Dandan Wang, Veronika Soshnikova, Deok Chun Yang
There has been a growing interest in the design of environmentally affable and biocompatible nanoparticles among scientists to find novel and safe biomaterials. Panax ginseng Meyer berries have unique phytochemical profile and exhibit beneficial pharmacological activities such as antihyperglycemic, antiobesity, antiaging, and antioxidant properties. A comprehensive study of the biologically active compounds in ginseng berry extract (GBE) and the ability of ginseng berry (GB) as novel material for the biosynthesis of gold nanoparticles (GBAuNPs) and silver nanoparticles (GBAgNPs) was conducted...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28259121/uncouplers-of-oxidation-and-phosphorylation-as-antiaging-compounds
#5
REVIEW
D A Knorre, F F Severin
Food restriction causes a set of physiological changes that reduce the rate of aging. At the level of an organism, these changes are initiated by a hormonal response, which in turn activates certain intracellular signaling cascades. As a result, cells increase their antioxidant capacities and decrease the risk of cancerous transformation. A number of small molecule compounds activating these signaling cascades have been described. One could expect that direct pharmacological activation of the signaling can produce a stronger antiaging effect than that achieved by the indirect hormonal stimulation...
December 2016: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28250796/neuroprotective-properties-of-panax-notoginseng-saponins-via-preventing-oxidative-stress-injury-in-samp8-mice
#6
Jin-Lan Huang, Xin Jing, Xin Tian, Mei-Chun Qin, Zhe-Hao Xu, Deng-Pan Wu, Zhen-Guo Zhong
Inhibiting oxidative damage in early stage of Alzheimer's disease (AD) is considered as a strategy for AD treatment. Our previous study has shown that Panax notoginseng saponins (PNS) have an antiaging action by increasing the levels of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-PX) in the serum of aged rats. In this study, we aimed to investigate the effects of PNS on antioxidant enzymes and uncoupling proteins (UCPs) involved in oxidative stress in AD mice. The results showed that PNS prevented neuronal loss in hippocampal CA1 region and alleviated pathomorphological change of neurons in CA1 region...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28216876/wheatgrass-extract-ameliorates-hypoxia-induced-mucin-gene-expression-in-a549-cells
#7
Ju Hwan Sim, Moon-Hee Choi, Hyun-Jae Shin, Ji-Eun Lee
BACKGROUND: Wheatgrass is known to have antioxidant, antiaging, and anti-inflammatory effect. However, its protective effect against hypoxia is not yet evaluated. OBJECTIVE: In this study, we evaluated the protective and anti-inflammatory effect of wheatgrass against the hypoxia in airway epithelial cells. MATERIALS AND METHODS: A549 human lung adenocarcinoma cells were incubated in a hypoxic condition (CO2 5%/O2 1%) for 24 hr in the presence of different concentration of wheatgrass 50, 75, 100, and 150 μg/mL, and the magnitude of each immunologic response produced by the A549 cells was compared...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28203099/a-new-dermocosmetic-containing-retinaldehyde-delta-tocopherol-glucoside-and-glycylglycine-oleamide-for-managing-naturally-aged-skin-results-from-in-vitro-to-clinical-studies
#8
Céline Rouvrais, Daniel Bacqueville, Patrick Bogdanowicz, Marie-José Haure, Laure Duprat, Christine Coutanceau, Nathalie Castex-Rizzi, Hélène Duplan, Valérie Mengeaud, Sandrine Bessou-Touya
INTRODUCTION: Natural aging of skin tissues, the addition of the cumulative action of the time and radiation exposure result in skin atrophy, wrinkles and degeneration of the extracellular matrix (ECM). The aim of the study was to investigate the beneficial effect of a combination containing retinaldehyde (RAL), delta-tocopherol glucoside (delta-TC) and glycylglycine ole-amide (GGO) and of a dermocosmetic containing the combination. MATERIALS AND METHODS: The protective effect of the combination was assessed through in vitro gene expression of ultraviolet (UV)-irradiated fibroblasts...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28189068/passiflora-tarminiana-fruits-reduce-uvb-induced-photoaging-in-human-skin-fibroblasts
#9
Karent Bravo, Luisa Duque, Federico Ferreres, Diego A Moreno, Edison Osorio
Skin aging is a complex process that is strongly affected by UV radiation, which stimulates the production of reactive oxygen species (ROS) in the epidermis and dermis and subsequently causes skin damage. Among the major consequences are increased collagen degradation and reduced collagen synthesis. Previous reports have demonstrated the beneficial effects of polyphenols for healthy skin. Passiflora tarminiana Coppens & V.E. Barney, a species of the Passifloraceae family, is widely distributed in South America and is rich in flavonoids...
February 3, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28155599/a-critical-review-of-the-characterization-of-polyphenol-protein-interactions-and-of-their-potential-use-for-improving-food-quality
#10
Maria Rosa Perez-Gregorio, Jesús Simal-Gándara
BACKGROUND: Interest in protein-phenol interactions in biological systems has grown substantially in recent decades. METHODS: The interest has focused largely on food systems in response to reports on the prominent roles of phenolic compounds in nutrition and health. RESULTS: Phenolic compounds can have both favourable and adverse nutritional effects. Polyphenols are widely known for their antioxidant, anti-inflammatory, anticancer and antiaging properties; however, they have also been ascribed anti-nutritional effects resulting from interactions with some proteins and enzymes...
February 2, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28138219/resveratrol-inhibits-transforming-growth-factor-%C3%AE-2-induced-epithelial-to-mesenchymal-transition-in-human-retinal-pigment-epithelial-cells-by-suppressing-the-smad-pathway
#11
Ching-Long Chen, Yi-Hao Chen, Ming-Cheng Tai, Chang-Min Liang, Da-Wen Lu, Jiann-Torng Chen
Proliferative vitreoretinopathy (PVR) is the main cause of failure following retinal detachment surgery. Transforming growth factor (TGF)-β2-induced epithelial-to-mesenchymal transition (EMT) plays an important role in the development of PVR, and EMT inhibition decreases collagen gel contraction and fibrotic membrane formation, resulting in prevention of PVR. Resveratrol is naturally found in red wine and has inhibitory effects on EMT. Resveratrol is widely used in cardioprotection, neuroprotection, chemotherapy, and antiaging therapy...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28123324/antiaging-effects-of-the-mixture-of-panax-ginseng-and-crataegus-pinnatifida-in-human-dermal-fibroblasts-and-healthy-human-skin
#12
Eunson Hwang, Sang-Yong Park, Chang Shik Yin, Hee-Taek Kim, Yong Min Kim, Tae Hoo Yi
BACKGROUND: Human skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging, UVB irradiation leads to upregulation of matrix metalloproteinase-1, which then causes collagen degradation and premature aging. Mixtures of medicinal plants have traditionally been used as drugs in oriental medicine. Based on the previously reported antioxidant properties of Panax ginseng Meyer and Crataegus pinnatifida, we hypothesized that the mixture of P...
January 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28123310/cosmeceutical-product-consisting-of-biomimetic-peptides-antiaging-effects-in-vivo-and-in-vitro
#13
Zarema I Gazitaeva, Anna O Drobintseva, Yongji Chung, Victoria O Polyakova, Igor M Kvetnoy
BACKGROUND: Biomimetic peptides are synthetic compounds that are identical to amino acid sequence synthesized by an organism and can interact with growth factor receptors and provide antiaging clinical effects. PURPOSE: The purpose of this study was to investigate the effects of biomimetic peptides on the repair processes in the dermis using a model of cell cultures and in vivo. PATIENTS AND METHODS: Five female volunteers were subjected to the injection of biomimetic peptides 1 month prior to the abdominoplasty procedure...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28109165/melatonin-and-sirtuins-a-not-so-unexpected-relationship
#14
REVIEW
Juan C Mayo, Rosa M Sainz, Pedro González Menéndez, Vanesa Cepas, Dun-Xian Tan, Russel J Reiter
Epigenetic modifications, including methylation or acetylation as well as post-transcriptional modifications, are mechanisms used by eukaryotic cells to increase the genome diversity in terms of differential gene expression and protein diversity. Among these modifying enzymes, sirtuins, a class III histone deacetylase (HDAC) enzymes, are of particular importance. Sirtuins regulate the cell cycle, DNA repair, cell survival, and apoptosis, thus having important roles in normal and cancer cells. Sirtuins can also regulate metabolic pathways by changing preference for glycolysis under aerobic conditions as well as glutaminolysis...
January 21, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28098506/capsicum-annuum-var-grossum-bell-pepper-inhibits-%C3%AE-secretase-activity-and-%C3%AE-amyloid1-40-aggregation
#15
Omodesola Oluwafisayo Ogunruku, Ganiyu Oboh, Sabina Passamonti, Federica Trammer, Aline Augusti Boligon
The deposition of amyloid protein as senile plaques is the major signature of Alzheimer's disease (AD). It is produced by the sequential cleavage of the amyloid precursor protein by secretases. Moreover, peppers are noted for their antiaging and cognitive enhancing properties. Thus, in this study, the effects of polyphenol-rich extracts from bell pepper on amyloid production and aggregation in vitro were investigated. Bell pepper (ripe and unripe) was extracted with methanol-1 N HCl (1:1 v/v). Thereafter, the inhibitory potentials of the extracts on β-secretase and β-amyloid1-40 aggregation were determined...
February 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28087676/the-longitudinal-study-of-aging-in-human-young-adults-knowledge-gaps-and-research-agenda
#16
Terrie E Moffitt, Daniel W Belsky, Andrea Danese, Richie Poulton, Avshalom Caspi
BACKGROUND: To prevent onset of age-related diseases and physical and cognitive decline, interventions to slow human aging and extend health span must eventually be applied to people while they are still young and healthy. Yet most human aging research examines older adults, many with chronic disease, and little is known about aging in healthy young humans. METHOD: This article explains how this knowledge gap is a barrier to extending health span and puts forward the case that geroscience should invest in researching the pace of aging in young adults...
February 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28069944/soluble-klotho-binds-monosialoganglioside-to-regulate-membrane-microdomains-and-growth-factor-signaling
#17
George Dalton, Sung-Wan An, Saif I Al-Juboori, Nicole Nischan, Joonho Yoon, Evgenia Dobrinskikh, Donald W Hilgemann, Jian Xie, Kate Luby-Phelps, Jennifer J Kohler, Lutz Birnbaumer, Chou-Long Huang
Soluble klotho, the shed ectodomain of the antiaging membrane protein α-klotho, is a pleiotropic endocrine/paracrine factor with no known receptors and poorly understood mechanism of action. Soluble klotho down-regulates growth factor-driven PI3K signaling, contributing to extension of lifespan, cardioprotection, and tumor inhibition. Here we show that soluble klotho binds membrane lipid rafts. Klotho binding to rafts alters lipid organization, decreases membrane's propensity to form large ordered domains for endocytosis, and down-regulates raft-dependent PI3K/Akt signaling...
January 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28062841/metal-based-superoxide-dismutase-and-catalase-mimics-reduce-oxidative-stress-biomarkers-and-extend-life-span-of-saccharomyces-cerevisiae
#18
Thales de P Ribeiro, Fernanda L Fonseca, Mariana D C de Carvalho, Rodrigo M da C Godinho, Fernando Pereira de Almeida, Tatiana D Saint'Pierre, Nicolás A Rey, Christiane Fernandes, Adolfo Horn, Marcos D Pereira
Aging is a natural process characterized by several biological changes. In this context, oxidative stress appears as a key factor that leads cells and organisms to severe dysfunctions and diseases. To cope with reactive oxygen species and oxidative-related damage, there has been increased use of superoxide dismutase (SOD)/catalase (CAT) biomimetic compounds. Recently, we have shown that three metal-based compounds {[Fe(HPClNOL)Cl2]NO3, [Cu(HPClNOL)(CH3CN)](ClO4)2 and Mn(HPClNOL)(Cl)2}, harboring in vitro SOD and/or CAT activities, were critical for protection of yeast cells against oxidative stress...
January 15, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28033643/suspension-threads
#19
Elen C D J De Masi, Flávia D J De Masi, Roberta D J De Masi
Suture threads are a minimally invasive surgical technique for facial rejuvenation. Its use was initiated by Sulamanidze et al with propylene after Serdev introduced suture with polycaproamide; however, these types of suture increased inflammatory reaction. For correction of the aging face, surgeons are devising more procedures with fewer incisions and shorter postoperative recovery periods. Many of these procedures use absorbable and nonabsorbable sutures in the dermis and subcutis to lift lax skin. The polydioxanone suture is currently a great option for antiaging treatment, because besides the ease of applicability and good results, it also has a low incidence of adverse reactions...
December 2016: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28025308/2-5-dimethyl-celecoxib-extends-drosophila-life-span-via-a-mechanism-that-requires-insulin-and-target-of-rapamycin-signaling
#20
Qi Wu, Ting Lian, Xiaolan Fan, Chaochun Song, Uma Gaur, Xueping Mao, Deying Yang, Matthew D W Piper, Mingyao Yang
The search for antiaging drugs is a key component of gerontology research. A few drugs with positive effects on life span in model organisms have been found. Here, we report that 2,5-dimethyl-celecoxib, a derivative of the anti-inflammatory drug celecoxib, can extend Drosophila life span and delay aging by a mechanism involving insulin signaling and target of rapamycin signaling. Importantly, its positive effects were apparent when the treatment window was restricted to the beginning of life or the later half...
December 26, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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