keyword
MENU ▼
Read by QxMD icon Read
search

gut dysbiosis

keyword
https://www.readbyqxmd.com/read/29770393/consumption-of-pomegranate-decreases-plasma-lipopolysaccharide-binding-protein-levels-a-marker-of-metabolic-endotoxemia-in-patients-with-newly-diagnosed-colorectal-cancer-a-randomized-controlled-clinical-trial
#1
A González-Sarrías, M A Núñez-Sánchez, M A Ávila-Gálvez, T Monedero-Saiz, F J Rodríguez-Gil, Francisco Martínez-Díaz, M V Selma, J C Espín
Gut microbiota dysbiosis alters the intestinal barrier function, increases plasma lipopolysaccharide (LPS) levels, which promotes endotoxemia, and contributes to the onset and development of colorectal cancer (CRC). We report here for the first time the reduction of plasma LPS-binding protein (LBP) levels, a marker of endotoxemia, after pomegranate consumption in newly diagnosed CRC patients.
May 17, 2018: Food & Function
https://www.readbyqxmd.com/read/29769268/pbdes-altered-gut-microbiome-and-bile-acid-homeostasis-in-male-c57bl-6-mice
#2
Cindy Yanfei Li, Joseph L Dempsey, Dongfang Wang, SooWan Lee, Kris M Weigel, Qiang Fei, Deepak Kumar Bhatt, Bhagwat Prasad, Daniel Raftery, Haiwei Gu, Julia Yue Cui
Polybrominated diphenyl ethers (PBDEs) are persistent environmental contaminants with well-characterized toxicities in host organs. Gut microbiome is increasingly recognized as an important regulator of xenobiotic biotransformation; however, little is known about its interactions with PBDEs. Primary bile acids (BAs) are metabolized by the gut microbiome into more lipophilic secondary BAs that may be absorbed and interact with certain host receptors. The goal of this study was to test our hypothesis that PBDEs cause dysbiosis and aberrant regulation of BA homeostasis...
May 16, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29766049/interleukin-1%C3%AE-deficient-mice-have-an-altered-gut-microbiota-leading-to-protection-from-dextran-sodium-sulfate-induced-colitis
#3
Moran Nunberg, Nir Werbner, Hadar Neuman, Marina Bersudsky, Alex Braiman, Moshe Ben-Shoshan, Meirav Ben Izhak, Yoram Louzoun, Ron N Apte, Elena Voronov, Omry Koren
Inflammatory bowel diseases (IBD) are a group of chronic inflammatory disorders of the intestine, with as-yet-unclear etiologies, affecting over a million people in the United States alone. With the emergence of microbiome research, numerous studies have shown a connection between shifts in the gut microbiota composition (dysbiosis) and patterns of IBD development. In a previous study, we showed that interleukin 1α (IL-1α) deficiency in IL-1α knockout (KO) mice results in moderate dextran sodium sulfate (DSS)-induced colitis compared to that of wild-type (WT) mice, characterized by reduced inflammation and complete healing, as shown by parameters of weight loss, disease activity index (DAI) score, histology, and cytokine expression...
May 2018: MSystems
https://www.readbyqxmd.com/read/29762899/metagenomics-analysis-of-gut-microbiota-in-a-high-fat-diet-induced-obesity-mouse-model-fed-with-epigallocatechin-3-o-3-o-methyl-gallate-egcg3-me
#4
Xin Zhang, Yuhui Chen, Jieyu Zhu, Man Zhang, Chi-Tang Ho, Qingrong Huang, Jinxuan Cao
SCOPE: (-)-Epigallocatechin 3-O-(3-O-methyl) gallate (EGCG3''Me) has been shown to have a modulatory effect on human intestinal microbiota, and the relationship between intestinal flora and obesity has attracted more and more attention recently. Here, we investigated the potential link between EGCG3''Me and gut microbiota composition, as well as the underlying mechanisms of the anti-obesity activity of EGCG3''Me. METHODS AND RESULTS: EGCG3''Me was prepared from oolong tea by column chromatography, and the influence of EGCG3''Me on intestinal microbiota was analysed using a human flora-associated high fat diet (HFD)-induced obesity mouse model by metagenomics...
May 15, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29762384/microbial-metabolism-in-the-mammalian-gut-molecular-mechanisms-and-clinical-implications
#5
Anne Hall, James Versalovic
Human intestinal microbes participate actively at the interface of diet, nutrition, and overall health status. These biodiverse communities of microorganisms have a broader metabolic repertoire compared with their host, and they are able to synthesize and degrade substrates that would be otherwise unavailable. In recent years, we have recognized that healthy microbial communities are important for energy harvest and the regulation of body systems outside the digestive tract. Microbial dysbiosis, however, has been implicated in a number of human disorders, including obesity and inflammation...
June 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29761927/on-the-potential-role-of-intestinal-microbial-community-in-hepatocarcinogenesis-in-chronic-hepatitis-b
#6
REVIEW
Ashraf Mohamadkhani
The chronic infection of hepatitis B virus (HBV) is the most potent risk factor for the development of cirrhosis and hepatocellular carcinoma (HCC). The association of intestinal microbiota alteration with progressive liver disease has been investigated in recent studies. Overgrowth of potentially pathogenic bacteria of gram-negative species and, in particular, a significant increase in the fecal count of Escherichia coli (E. coli) are characterized in the presence of HCC. This study was conducted to describe the characteristics of the intestinal microbiota related to the presence of HCC in HBV-carrier patients...
May 15, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29760448/the-gut-microbiota-and-the-brain-gut-kidney-axis-in-hypertension-and-chronic-kidney-disease
#7
REVIEW
Tao Yang, Elaine M Richards, Carl J Pepine, Mohan K Raizada
Crosstalk between the gut microbiota and the host has attracted considerable attention owing to its involvement in diverse diseases. Chronic kidney disease (CKD) is commonly associated with hypertension and is characterized by immune dysregulation, metabolic disorder and sympathetic activation, which are all linked to gut dysbiosis and altered host-microbiota crosstalk. In this Review, we discuss the complex interplay between the brain, the gut, the microbiota and the kidney in CKD and hypertension and explain our brain-gut-kidney axis hypothesis for the pathogenesis of these diseases...
May 14, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29756631/patients-with-acne-vulgaris-have-a-distinct-gut-microbiota-in-comparison-with-healthy-controls
#8
Yongqiong Deng, Hong Wang, Jiyuan Zhou, Yunzhou Mou, Guiqiang Wang, Xia Xiong
Acne vulgaris has been postulated to have a gastrointestinal mechanism; however, little is known about gut microbiota dysfunction in this condition. The aim of this cross-sectional study was to investigate whether the gut microbiota is altered in acne. Faecal bacterial diversity was analysed in 43 patients with acne and 43 controls, using hypervariable tag sequencing of the V3-V4 region of the 16S rDNA gene. Distinct differences were found in microbial diversity between patients with acne and controls (Shannon diversity index (p = 0...
May 14, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29750384/effects-of-moderate-voluntary-ethanol-consumption-on-the-rat-and-human-gut-microbiome
#9
Kassi L Kosnicki, Jerrold C Penprase, Patricia Cintora, Pedro J Torres, Greg L Harris, Susan M Brasser, Scott T Kelley
Many alcohol-induced health complications are directly attributable to the toxicity of alcohol or its metabolites, but another potential health impact of alcohol may be on the microbial communities of the human gut. Clear distinctions between healthy and diseased-state gut microbiota have been observed in subjects with metabolic diseases, and recent studies suggest that chronic alcoholism is linked to gut microbiome dysbiosis. Here, we investigated the effects of moderate levels of alcohol consumption on the gut microbiome in both rats and humans...
May 11, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29749635/microbial-and-metabolic-multi-omic-correlations-in-systemic-sclerosis-patients
#10
Chiara Bellocchi, Álvaro Fernández-Ochoa, Gaia Montanelli, Barbara Vigone, Alessandro Santaniello, Christian Milani, Rosa Quirantes-Piné, Isabel Borrás-Linares, Marco Ventura, Antonio Segura-Carrettero, Marta Eugenia Alarcón-Riquelme, Lorenzo Beretta
Intestinal microbiota has been associated with systemic autoimmune diseases, yet the functional consequences of these associations are elusive. We characterized the fecal microbiota (16S rRNA gene amplification and sequencing) and the plasma metabolome (high-performance liquid chromatography coupled to mass spectrometry) in 59 patients with systemic sclerosis (SSc) and 28 healthy controls (HCs). Microbial and metabolic data were cross-correlated to find meaningful associations after extensive data mining analysis and internal validation...
May 11, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29746836/early-life-antibiotic-driven-dysbiosis-leads-to-dysregulated-vaccine-immune-responses-in-mice
#11
Miriam Anne Lynn, Damon John Tumes, Jocelyn Mei Choo, Anastasia Sribnaia, Stephen James Blake, Lex Ee Xiang Leong, Graeme Paul Young, Helen Siobhan Marshall, Steve Lodewijk Wesselingh, Geraint Berian Rogers, David John Lynn
Antibody-mediated responses play a critical role in vaccine-mediated immunity. However, for reasons that are poorly understood, these responses are highly variable between individuals. Using a mouse model, we report that antibiotic-driven intestinal dysbiosis, specifically in early life, leads to significantly impaired antibody responses to five different adjuvanted and live vaccines. Restoration of the commensal microbiota following antibiotic exposure rescues these impaired responses. In contrast, antibiotic-treated adult mice do not exhibit impaired antibody responses to vaccination...
May 9, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29743833/why-is-it-so-difficult-to-evaluate-faecal-microbiota-transplantation-as-a-treatment-for-ulcerative-colitis
#12
REVIEW
Natalie Grace Fairhurst, Simon P L Travis
Faecal microbiota transplantation (FMT) has recently re-emerged as a viable therapeutic option for colonic disorders. Its efficacy has been proved in the treatment of Clostridium difficile infection which has encouraged research into the use of FMT for other disorders involving gut dysbiosis, such as ulcerative colitis (UC), a chronic inflammatory disease characterized by relapsing and remitting colonic inflammation. Although the FMT protocol for C. difficile treatment is well established, there are numerous additional factors to consider when applying FMT to treat inflammatory diseases...
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29743614/healthy-hosts-rule-within-ecological-forces-shaping-the-gut-microbiota
#13
REVIEW
Mariana X Byndloss, Sandy R Pernitzsch, Andreas J Bäumler
A balanced gut microbiota is important for human health, but the mechanisms that maintain homeostasis are incompletely understood. Recent insights suggest the host plays a key role in shaping its gut microbiota to be beneficial. While host control in the small intestine curbs bacterial numbers to avoid competition for simple sugars and amino acids, the host limits oxygen availability in the large intestine to obtain microbial fermentation products from fiber. Epithelial cells are major players in imposing ecological control mechanisms, which involves the release of antimicrobial peptides by small-intestinal Paneth cells and maintenance of luminal anaerobiosis by epithelial hypoxia in the colon...
May 9, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29743160/microbiome-and-cardiovascular-disease-in-ckd
#14
REVIEW
Anna Jovanovich, Tamara Isakova, Jason Stubbs
Patients with CKD exhibit a disproportionate burden of cardiovascular mortality, which likely stems from the presence of unique, nontraditional risk factors that accompany deteriorating kidney function. Mounting evidence suggests that alterations to the intestinal microbiome in CKD may serve as one such risk factor. The human intestinal tract is home to >100 trillion micro-organisms made up of a collection of commensal, symbiotic, and pathogenic species. These species along with their local environment constitute the intestinal microbiome...
May 9, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29742432/il-9-and-mast-cells-are-key-players-of-candida-albicans-commensalism-and-pathogenesis-in-the-gut
#15
Giorgia Renga, Silvia Moretti, Vasilis Oikonomou, Monica Borghi, Teresa Zelante, Giuseppe Paolicelli, Claudio Costantini, Marco De Zuani, Valeria Rachela Villella, Valeria Raia, Rachele Del Sordo, Andrea Bartoli, Monia Baldoni, Jean-Christophe Renauld, Angelo Sidoni, Enrico Garaci, Luigi Maiuri, Carlo Pucillo, Luigina Romani
Candida albicans is implicated in intestinal diseases. Identifying host signatures that discriminate between the pathogenic versus commensal nature of this human commensal is clinically relevant. In the present study, we identify IL-9 and mast cells (MCs) as key players of Candida commensalism and pathogenicity. By inducing TGF-β in stromal MCs, IL-9 pivotally contributes to mucosal immune tolerance via the indoleamine 2,3-dioxygenase enzyme. However, Candida-driven IL-9 and mucosal MCs also contribute to barrier function loss, dissemination, and inflammation in experimental leaky gut models and are upregulated in patients with celiac disease...
May 8, 2018: Cell Reports
https://www.readbyqxmd.com/read/29740541/anti-biofilm-properties-of-the-fecal-probiotic-lactobacilli-against-vibrio-spp
#16
Sumanpreet Kaur, Preeti Sharma, Namarta Kalia, Jatinder Singh, Sukhraj Kaur
Diarrheal disease caused by Vibrio cholerae is endemic in developing countries including India and is associated with high rate of mortality especially in children. V. cholerae is known to form biofilms on the gut epithelium, and the biofilms once formed are resistant to the action of antibiotics. Therefore agents that prevent the biofilm formation and disperse the preformed biofilms are associated with therapeutic benefits. The use of antibiotics for the treatment of cholera is associated with side effects such as gut dysbiosis due to depletion of gut microflora, and the increasing problem of antibiotic resistance...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29740421/toxicity-of-food-grade-tio-2-to-commensal-intestinal-and-transient-food-borne-bacteria-new-insights-using-nano-sims-and-synchrotron-uv-fluorescence-imaging
#17
Joanna M Radziwill-Bienkowska, Pauline Talbot, Jasper B J Kamphuis, Véronique Robert, Christel Cartier, Isabelle Fourquaux, Esther Lentzen, Jean-Nicolas Audinot, Frédéric Jamme, Matthieu Réfrégiers, Jacek K Bardowski, Philippe Langella, Magdalena Kowalczyk, Eric Houdeau, Muriel Thomas, Muriel Mercier-Bonin
Titanium dioxide (TiO2 ) is commonly used as a food additive (E171 in the EU) for its whitening and opacifying properties. However, a risk of intestinal barrier disruption, including dysbiosis of the gut microbiota, is increasingly suspected because of the presence of a nano-sized fraction in this additive. We hypothesized that food-grade E171 and Aeroxyde P25 (identical to the NM-105 OECD reference nanomaterial in the European Union Joint Research Centre) interact with both commensal intestinal bacteria and transient food-borne bacteria under non-UV-irradiated conditions...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29738946/tributyltin-exposure-induces-gut-microbiome-dysbiosis-with-increased-body-weight-gain-and-dyslipidemia-in-mice
#18
Hao Guo, Haotian Yan, Dong Cheng, Xinglong Wei, Ruirui Kou, Jiliang Si
Gut microbiome dysbiosis plays a profound role in the pathogenesis of obesity and tributyltin (TBT) has been found as an environmental obesogen. However, whether TBT could disturb gut microbiome and the relationship between obesity induced by TBT exposure and alteration in gut microbiota are still unknown. In order to assess the association between them, mice were exposed to TBTCl (50 μg kg-1 ) once every three days from postnatal days (PNDs) 24 to 54. The results demonstrated that TBT exposure resulted in increased body weight gain, lager visceral fat accumulation and dyslipidemia in male mice on PND 84...
May 3, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29737913/pathophysiology-of-ibd-associated-diarrhea
#19
Arivarasu N Anbazhagan, Shubha Priyamvada, Waddah A Alrefai, Pradeep K Dudeja
Inflammatory bowel diseases broadly categorized into Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory disorders of the gastrointestinal tract with increasing prevalence worldwide. The etiology of the disease is complex and involves a combination of genetic, environmental, immunological and gut microbial factors. Recurring and bloody diarrhea is the most prevalent and debilitating symptom in IBD. The pathogenesis of IBD-associated diarrhea is multifactorial and is essentially an outcome of mucosal damage caused by persistent inflammation resulting in dysregulated intestinal ion transport, impaired epithelial barrier function and increased accessibility of the pathogens to the intestinal mucosa...
May 8, 2018: Tissue Barriers
https://www.readbyqxmd.com/read/29736898/high-fat-diet-consumption-induces-microbiota-dysbiosis-and-intestinal-inflammation-in-zebrafish
#20
Nerea Arias-Jayo, Leticia Abecia, Laura Alonso-Sáez, Andoni Ramirez-Garcia, Alfonso Rodriguez, Miguel A Pardo
Energy-dense foods and overnutrition represent major starting points altering lipid metabolism, systemic inflammation and gut microbiota. The aim of this work was to investigate the effects of a high-fat diet (HFD) over a period of 25 days on intestinal microbiota and inflammation in zebrafish. Microbial composition of HFD-fed animals was analysed and compared to controls by 16S rRNA sequencing and quantitative PCR. The expression level on several genes related to inflammation was tested. Furthermore, microscopic assessment of the intestine was performed in both conditions...
May 7, 2018: Microbial Ecology
keyword
keyword
53097
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"