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https://www.readbyqxmd.com/read/29458159/strawberry-extracts-efficiently-counteract-inflammatory-stress-induced-by-the-endotoxin-lipopolysaccharide-in-human-dermal-fibroblast
#1
Massimiliano Gasparrini, Francesca Giampieri, Tamara Y Forbes-Hernandez, Sadia Afrin, Danila Cianciosi, Patricia Reboredo-Rodriguez, Alfonso Varela-Lopez, JiaoJiao Zhang, Josè L Quiles, Bruno Mezzetti, Stefano Bompadre, Maurizio Battino
A protracted pro-inflammatory state is the common denominator in the development, progression and complication of the common chronic diseases. Dietary antioxidants represent an efficient tool to counteract this inflammatory state. The aim of the present work was to evaluate the effects of strawberry extracts on inflammation evoked by E. Coli lipopolysaccharide in Human Dermal Fibroblast, by measuring reactive oxygen species production, apoptosis rate, antioxidant enzymes activity, mitochondria functionality and also investigating the molecular pathway involved in inflammatory and antioxidant response...
February 16, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29458085/the-effect-of-surface-charge-and-ph-on-the-physiological-behaviour-of-cobalt-copper-manganese-antimony-zinc-and-titanium-oxide-nanoparticles-in-vitro
#2
Tiina Titma
The precise knowledge on various interactions of metal nanoparticles (NP) in a living organism is scarce. It is expected that metals can bind to nucleic acids, peptides and proteins (e.g. enzymes), and modify the functioning of vital cellular compartments after entering the organism. The predictive factors for quantitative nanostructure-activity relationship (QNAR) analysis could enhance efficient and harmless usage of nanoparticles (NPs) in the industry as well in the medicine. The studies value the composition of the NP corona determined by time, temperature and source of protein which has been found to implicate the physiological behaviour of NPs...
February 16, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29457925/controlled-release-of-mitomycin-c-from-phemah-cu-ii-cryogel-membranes
#3
Monireh Bakhshpour, Handan Yavuz, Adil Denizli
Molecular imprinting technique was used for the preparation of antibiotic and anti-neoplastic chemotherapy drug (mitomycin C) imprinted cryogel membranes (MMC-ICM). The membranes were synthezied by using metal ion coordination interactions with N-methacryloyl-(l)-histidine methyl ester (MAH) functional monomer and template molecules (i.e. MMC). The 2-hydroxyethyl methacrylate (HEMA) monomer and methylene bisacrylamide (MBAAm) crosslinker were used for the preparation of mitomycin C imprinted cryogel membranes by radical suspension polymerization technique...
February 19, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29457910/mechanistic-analysis-of-ion-association-between-dendrigraft-poly-l-lysine-and-8-anilino-1-naphthalenesulfonate-at-liquid-liquid-interfaces
#4
Hirohisa Nagatani, Masataka Fujisawa, Hisanori Imura
Molecular association between biocompatible dendritic polymers, dendrigraft poly-L-lysines (DGLs), and an anionic fluorescent probe, 8-anilino-1-naphthalenesulfonate (ANS- ), was studied at the polarized water|1,2-dichloroethane (DCE) interface. The fluorescence intensity of ANS measured in aqueous solution was enhanced by the coexistence of DGL over a wide pH range (2 < pH < 10), where ANS and DGL exist as a monoanionic form and polycation, respectively. The voltammetric responses indicated that the positively charged DGL was adsorbed at the water|DCE interface, while ANS- was transferred across the interface accompanied by the adsorption process...
February 19, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29457665/comparative-analysis-of-lipid-mediated-crispr-cas9-genome-editing-techniques
#5
Kelsey P Ringer, Mark G Roth, Mitchell S Garey, Ted B Piorczynski, Arminda Suli, Jason M Hansen, Jonathan K Alder
CRISPR-Cas technology has revolutionized genome engineering. While Cas9 was not the first programmable endonuclease identified, its simplicity of use has driven widespread adoption in a short period of time. While CRISPR-Cas genome editing holds enormous potential for clinical applications, its use in laboratory settings for genotype-phenotype studies and genome-wide screens has led to breakthroughs in the understanding of many molecular pathways. Numerous protocols have been described for introducing CRISPR-Cas components into cells, and here we sought to simplify and optimize a protocol for genome editing using readily available and inexpensive tools...
February 19, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29457632/rapid-eradication-of-bacterial-phytopathogens-by-atmospheric-pressure-glow-discharge-generated-in-contact-with-a-flowing-liquid-cathode
#6
Agata Motyka, Anna Dzimitrowicz, Piotr Jamroz, Ewa Lojkowska, Wojciech Sledz, Pawel Pohl
Diseases caused by phytopathogenic bacteria are responsible for significant economic losses, and these bacteria spread through diverse pathways including waterways and industrial wastes. It is therefore of interest to develop potent methods for their eradication. Here, antibacterial properties of direct current atmospheric pressure glow discharge (dc-APGD) generated in contact with flowing bacterial suspensions were examined against five species of phytopathogens. Complete eradication of Clavibacter michiganensis subsp...
February 19, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29457226/coordination-and-trade-offs-among-hydraulic-safety-efficiency-and-drought-avoidance-traits-in-amazonian-rainforest-canopy-tree-species
#7
Louis S Santiago, Mark E De Guzman, Christopher Baraloto, Jacob E Vogenberg, Max Brodie, Bruno Hérault, Claire Fortunel, Damien Bonal
Predicting responses of tropical forests to climate change-type drought is challenging because of high species diversity. Detailed characterization of tropical tree hydraulic physiology is necessary to evaluate community drought vulnerability and improve model parameterization. Here, we measured xylem hydraulic conductivity (hydraulic efficiency), xylem vulnerability curves (hydraulic safety), sapwood pressure-volume curves (drought avoidance) and wood density on emergent branches of 14 common species of Eastern Amazonian canopy trees in Paracou, French Guiana across species with the densest and lightest wood in the plot...
February 19, 2018: New Phytologist
https://www.readbyqxmd.com/read/29457139/enhanced-n-doping-efficiency-of-a-naphthalenediimide-based-copolymer-through-polar-side-chains-for-organic-thermoelectrics
#8
David Kiefer, Alexander Giovannitti, Hengda Sun, Till Biskup, Anna Hofmann, Marten Koopmans, Camila Cendra, Stefan Weber, L Jan Anton Koster, Eva Olsson, Jonathan Rivnay, Simone Fabiano, Iain McCulloch, Christian Müller
N-doping of conjugated polymers either requires a high dopant fraction or yields a low electrical conductivity because of their poor compatibility with molecular dopants. We explore n-doping of the polar naphthalenediimide-bithiophene copolymer p(gNDI-gT2) that carries oligoethylene glycol-based side chains and show that the polymer displays superior miscibility with the benzimidazole-dimethylbenzenamine-based n-dopant N-DMBI. The good compatibility of p(gNDI-gT2) and N-DMBI results in a relatively high doping efficiency of 13% for n-dopants, which leads to a high electrical conductivity of more than 10-1 S cm-1 for a dopant concentration of only 10 mol % when measured in an inert atmosphere...
February 9, 2018: ACS Energy Letters
https://www.readbyqxmd.com/read/29456993/measuring-adolescent-self-awareness-and-accuracy-using-a-performance-based-assessment-and-parental-report
#9
Sharon Zlotnik, Joan Toglia
Aim: The aim of this study was to assess awareness of performance and performance accuracy for a task that requires executive functions (EF), among healthy adolescents and to compare their performance to their parent's ratings. Method: Participants: 109 healthy adolescents (mean age 15.2 ± 1.86 years) completed the Weekly Calendar Planning Activity (WCPA). The discrepancy between self-estimated and actual performance was used to measure the level of awareness. The participants were divided into high and low accuracy groups according to the WCPA accuracy median score...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29456907/nanoparticles-in-the-environment-where-do-we-come-from-where-do-we-go-to
#10
REVIEW
Mirco Bundschuh, Juliane Filser, Simon Lüderwald, Moira S McKee, George Metreveli, Gabriele E Schaumann, Ralf Schulz, Stephan Wagner
Nanoparticles serve various industrial and domestic purposes which is reflected in their steadily increasing production volume. This economic success comes along with their presence in the environment and the risk of potentially adverse effects in natural systems. Over the last decade, substantial progress regarding the understanding of sources, fate, and effects of nanoparticles has been made. Predictions of environmental concentrations based on modelling approaches could recently be confirmed by measured concentrations in the field...
2018: Environmental Sciences Europe
https://www.readbyqxmd.com/read/29456897/detection-of-essential-tremor-at-the-formula-see-text-band
#11
Xiaodong Yang, Syed Aziz Shah, Aifeng Ren, Dou Fan, Nan Zhao, Dongjian Cao, Fangming Hu, Masood Ur Rehman, Weigang Wang, Karen M Von Deneen, Jie Tian
Essential tremor (ET) is a neurological disorder characterized by rhythmic, involuntary shaking of a part or parts of the body. The most common tremor is seen in the hands/arms and fingers. This paper presents an evaluation of ETs monitoring based on finger-to-nose test measurement as captured by small wireless devices working in shortwave or [Formula: see text]-band frequency range. The acquired signals in terms of amplitude and phase information are used to detect a tremor in the hands. Linearly transforming raw phase data acquired in the [Formula: see text]-band were carried out for calibrating the phase information and to improve accuracy...
2018: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/29456636/expression-of-diaphragmatic-myostatin-and-correlation-with-apoptosis-in-rats-with-chronic-obstructive-pulmonary-disease
#12
Xu Zhou, Daijiao Yi, Yanhong Wu, Xinghua Pei, Haiming Yu, Yanhong Chen, Yu Jiang, Wenpu Li
Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and loss of lung function. The present study aimed to investigate the diaphragmatic protein expression of myostatin and its correlation with apoptosis in a rat model of CPOD. Sprague Dawley rats were randomly divided into a control group and a COPD group, the latter of which were exposed to cigarette smoke to build a rat model of COPD. The validity of the COPD model was evaluated by assessment of lung function and histopathological analysis...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456631/a-model-of-anterior-cruciate-ligament-injury-in-cynomolgus-monkeys-developed-via-arthroscopic-surgery
#13
Lei Zhang, Taiyuan Guan, Ji Qi, Shaoqun Zhang, Xin Zhou, Yang Liu, Shijie Fu
The anterior cruciate ligament (ACL) is an important structure that maintains the stability of knee joints. Animal models of ACL injury are helpful to explore its underlying mechanisms, and strategies for prevention, treatment and rehabilitation. Therefore, the aim of the present study was to develop an efficient model of ACL injury in cynomolgus monkeys via arthroscopic techniques. In the present study, 18 cynomolgus monkeys were randomly divided into a model group (n=6), a sham operation group (n=6) and a blank control group (n=6)...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456502/efficacy-of-cognitive-training-in-older-adults-with-and-without-subjective-cognitive-decline-is-associated-with-inhibition-efficiency-and-working-memory-span-not-with-cognitive-reserve
#14
Ramón López-Higes, María T Martín-Aragoneses, Susana Rubio-Valdehita, María L Delgado-Losada, Pedro Montejo, Mercedes Montenegro, José M Prados, Jaisalmer de Frutos-Lucas, David López-Sanz
The present study explores the role of cognitive reserve, executive functions, and working memory (WM) span, as factors that might explain training outcomes in cognitive status. Eighty-one older adults voluntarily participated in the study, classified either as older adults with subjective cognitive decline or cognitively intact. Each participant underwent a neuropsychological assessment that was conducted both at baseline (entailing cognitive reserve, executive functions, WM span and depressive symptomatology measures, as well as the Mini-Mental State Exam regarding initial cognitive status), and then 6 months later, once each participant had completed the training program (Mini-Mental State Exam at the endpoint)...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29456283/la-ce-isotope-measurements-by-multicollector-icpms
#15
Christiane Schnabel, Carsten Münker, Erik Strub
The138 La-138 Ce decay system (half-life 1.02 × 1011 years) is a potentially highly useful tool to unravel information about the timing of geological processes and about the interaction of geological reservoirs on earth, complementing information from the more popular147 Sm-143 Nd and176 Lu-176 Hf isotope systems. Previously published analytical protocols were limited to TIMS. Here we present for the first time an analytical protocol that employs MC-ICPMS, with an improved precision and sensitivity. To perform sufficiently accurate La-Ce measurements, an efficient ion-chromatographic procedure is required to separate Ce from the other rare earth elements (REE) and Ba quantitatively...
December 1, 2017: Journal of Analytical Atomic Spectrometry
https://www.readbyqxmd.com/read/29456125/development-and-validation-of-a-tool-to-measure-dietitians-self-efficacy-with-using-mobile-health-apps-in-dietetic-practice
#16
Juliana Chen, Margaret Allman-Farinelli
OBJECTIVE: To develop and validate a tool for assessing dietitians' self-efficacy with using mobile health (mHealth) apps in dietetic practice. DESIGN AND PARTICIPANTS: A tool for measuring mHealth app self-efficacy among dietitians was constructed based on a literature review, consultation with experts, and Bandura's self-efficacy scales development guide. Senior dietetic students and new graduate dietitians in Australia (n = 100) tested the tool. OUTCOME MEASURES AND ANALYSIS: Validation of the tool was conducted using factor analysis...
February 15, 2018: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/29456030/acute-phase-nutritional-screening-tool-associated-with-functional-outcomes-of-hip-fracture-patients-a-longitudinal-study-to-compare-mna-sf-must-nrs-2002-and-gnri
#17
Tatsuro Inoue, Shogo Misu, Toshiaki Tanaka, Tetsuya Kakehi, Rei Ono
BACKGROUND & AIMS: Several hip fracture patients are malnourished, but no study has attempted to determine the optimal nutritional screening tool for predicting functional outcomes. We investigated the association between each nutritional status assessed by four nutritional screening tools at admission and functional outcomes during the postoperative acute phase in hip fracture patients. METHODS: The Mini Nutritional Assessment-Short Form (MNA-SF), the Malnutrition Universal Screening Tool (MUST), the Nutritional Risk Score 2002 (NRS-2002) and the Geriatric Nutritional Risk Index (GNRI) were assessed at admission before surgery...
February 15, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29456016/monoclonal-antibody-based-in-vitro-potency-assay-as-a-predictor-of-antigenic-integrity-and-in-vivo-immunogenicity-of-a-respiratory-syncytial-virus-post-fusion-f-protein-based-vaccine
#18
Matieyendou Didier Djagbare, Li Yu, Arun Parupudi, Jenny Sun, Melissa L Coughlin, Benjamin S Rush, Gautam Sanyal
The post-fusion form of Respiratory Syncytial Virus (RSV) fusion (F) protein has been used recently in clinical trials as a potential vaccine antigen with the objective of eliciting protective immune response against RSV. In this paper, in vitro antigenicity and in vivo immunogenicity of recombinant, soluble F protein of RSV (RSVsF) were evaluated by several assays. In Vitro Relative Potency (IVRP) of RSVsF was measured in a sandwich ELISA using two antibodies, each specific for epitope site A or C. Therefore, IVRP reflected the integrity of the antigen in terms of changes in antibody binding affinity of either or both of these sites...
February 15, 2018: Vaccine
https://www.readbyqxmd.com/read/29455973/microbicidal-gentamicin-alginate-hydrogels
#19
Stalin Kondaveeti, Pedro Vinicius de Assis Bueno, Ana Maria Carmona-Ribeiro, Fernanda Esposito, Nilton Lincopan, Maria Rita Sierakowski, Denise Freitas Siqueira Petri
Sodium alginate (Alg) reacted with antibiotic gentamicin sulfate (GS) in an aqueous-phase condition mediated by carbodiimide chemistry, in the molar ratios Alg: GS of (1:0.5), (1:1) and (1:2). The Alg-GS conjugated derivatives were characterized by elemental analysis for nitrogen content, Fourier transform infrared spectroscopy in the attenuated total reflection mode (FTIR-ATR), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), thermogravimetric analyses (TGA) and water sorption measurements...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29454945/dextran-based-herbal-nanobiocomposite-membranes-for-scar-free-wound-healing
#20
Surabhi Singh, Amlan Gupta, Deepika Sharma, Bhuvanesh Gupta
Dextran based bionanocomposite membranes encapsulating clove oil (CO) and sandalwood oil (SO) that are capable of preventing infection due to their inherent virtue of antibacterial activity and modifying the wound healing cascade for accelerated scar free healing, were developed. A facile solvent casting technique was used to fabricate dextran/nanosoy/glycerol/chitosan (DNG/Ch) nanocomposite membranes followed by subsequent addition of CO and SO to obtain DNG/Ch/CO and DNG/Ch/SO herbal nanodressings. Dressings exhibited >98% antibacterial activity against both Staphylococcus aureus (S...
February 15, 2018: International Journal of Biological Macromolecules
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