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https://www.readbyqxmd.com/read/28346508/most-women-recover-from-psychological-distress-after-postoperative-complications-following-implant-or-diep-flap-breast-reconstruction-a-prospective-long-term-follow-up-study
#1
Reinier Timman, Jessica P Gopie, J Nick Brinkman, Annelies Kleijne, Caroline Seynaeve, Marian B E Menke-Pluymers, Moniek M Ter Kuile, Aad Tibben, Marc A M Mureau
BACKGROUND: Substantial complication rates after postmastectomy breast reconstruction (BR) in breast cancer patients have been reported. Few studies have reported on the resulting psychological distress (PD) and satisfaction with the aesthetic result in relation to postoperative complications after completion of implant or DIEP flap BR. The present study investigated whether women were able to recover from complication related distress in the long term. METHODS: PD was prospectively measured using questionnaires regarding anxiety, depression and cancer distress...
2017: PloS One
https://www.readbyqxmd.com/read/28346487/ml2motif-reliable-extraction-of-discriminative-sequence-motifs-from-learning-machines
#2
Marina M-C Vidovic, Marius Kloft, Klaus-Robert Müller, Nico Görnitz
High prediction accuracies are not the only objective to consider when solving problems using machine learning. Instead, particular scientific applications require some explanation of the learned prediction function. For computational biology, positional oligomer importance matrices (POIMs) have been successfully applied to explain the decision of support vector machines (SVMs) using weighted-degree (WD) kernels. To extract relevant biological motifs from POIMs, the motifPOIM method has been devised and showed promising results on real-world data...
2017: PloS One
https://www.readbyqxmd.com/read/28346444/genetic-variants-associated-with-mosaic-y-chromosome-loss-highlight-cell-cycle-genes-and-overlap-with-cancer-susceptibility
#3
Daniel J Wright, Felix R Day, Nicola D Kerrison, Florian Zink, Alexia Cardona, Patrick Sulem, Deborah J Thompson, Svanhvit Sigurjonsdottir, Daniel F Gudbjartsson, Agnar Helgason, J Ross Chapman, Steve P Jackson, Claudia Langenberg, Nicholas J Wareham, Robert A Scott, Unnur Thorsteindottir, Ken K Ong, Kari Stefansson, John R B Perry
The Y chromosome is frequently lost in hematopoietic cells, which represents the most common somatic alteration in men. However, the mechanisms that regulate mosaic loss of chromosome Y (mLOY), and its clinical relevance, are unknown. We used genotype-array-intensity data and sequence reads from 85,542 men to identify 19 genomic regions (P < 5 × 10(-8)) that are associated with mLOY. Cumulatively, these loci also predicted X chromosome loss in women (n = 96,123; P = 4 × 10(-6)). Additional epigenome-wide methylation analyses using whole blood highlighted 36 differentially methylated sites associated with mLOY...
March 27, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28346335/apparent-interfacial-tension-effects-in-protein-stabilized-emulsions-prepared-with-microstructured-systems
#4
Carme Güell, Montserrat Ferrando, Alexandre Trentin, Karin Schroën
Proteins are mostly used to stabilize food emulsions; however, production of protein containing emulsions is notoriously difficult to capture in scaling relations due to the complex behavior of proteins in interfaces, in combination with the dynamic nature of the emulsification process. Here, we investigate premix membrane emulsification and use the Ohnesorge number to derive a scaling relation for emulsions prepared with whey protein, bovine serum albumin (BSA), and a standard emulsifier Tween 20, at various concentrations (0...
March 25, 2017: Membranes
https://www.readbyqxmd.com/read/28346215/enhanced-optoelectronic-quality-of-perovskite-films-with-excess-ch3nh3i-for-high-efficient-solar-cells-in-ambient-air
#5
Yunhai Zhang, Huiru Lv, Can Cui, Lingbo Xu, Peng Wang, Hao Wang, Xuegong Yu, Jiangsheng Xie, Jiabin Huang, Zeguo Tang, Deren Yang
The solution-processed polycrystalline perovskite film contributes critically to the high photovoltaic performance of perovskite based solar cells (PSCs). The inevitable electronic trap states at grain boundaries and the intrinsic defects such as metallic lead (Pb0) and halide vacancies in perovskite film cause serious carrier recombination loss. Furthermore, the film can easily decompose into PbI2 in moisture atmosphere. Here, we introduce a simple strategy through a small increase in methylammonium iodide (CH3NH3I, MAI) molar proportion (5%) for perovskite fabrication in ambient air with a ~50% relative humidity...
March 27, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28346155/objectively-measured-sleep-and-health-related-quality-of-life-in-older-adults-with-type-2-diabetes-a-cross-sectional-study-from-the-alberta-s-caring-for-diabetes-study
#6
Steven T Johnson, Danielle Thiel, Fatima Al Sayah, Clark Mundt, Weiyu Qiu, Matthew P Buman, Jeff K Vallance, Jeffrey A Johnson
BACKGROUND AND AIM: Sleep is an important behavior for metabolic control and mental health in type 2 diabetes. The aim was to examine the relationship of objective estimates of sleep quantity and quality with health-related quality of life (HRQL) in adults with type 2 diabetes. MATERIALS AND METHODS: Participants completed a survey where HRQL was measured using the EQ-5D-5 L index score, and the SF-12 v2, which provides physical and mental composite summary (PCS and MCS) scores...
April 2017: Sleep Health
https://www.readbyqxmd.com/read/28346153/national-sleep-foundation-s-sleep-quality-recommendations-first-report
#7
Maurice Ohayon, Emerson M Wickwire, Max Hirshkowitz, Steven M Albert, Alon Avidan, Frank J Daly, Yves Dauvilliers, Raffaele Ferri, Constance Fung, David Gozal, Nancy Hazen, Andrew Krystal, Kenneth Lichstein, Monica Mallampalli, Giuseppe Plazzi, Robert Rawding, Frank A Scheer, Virend Somers, Michael V Vitiello
OBJECTIVES: To provide evidence-based recommendations and guidance to the public regarding indicators of good sleep quality across the life-span. METHODS: The National Sleep Foundation assembled a panel of experts from the sleep community and representatives appointed by stakeholder organizations (Sleep Quality Consensus Panel). A systematic literature review identified 277 studies meeting inclusion criteria. Abstracts and full-text articles were provided to the panelists for review and discussion...
February 2017: Sleep Health
https://www.readbyqxmd.com/read/28346146/social-support-social-strain-sleep-quality-and-actigraphic-sleep-characteristics-evidence-from-a-national-survey-of-us-adults
#8
Joon Chung
OBJECTIVE: To determine the associations between average family and friend social support and strain over 10 years and sleep quality, sleep efficiency, total sleep time, and night-to-night total sleep time variability. PARTICIPANTS: Non-institutionalized English-speaking US adults aged 34-81 who participated in the MacArthur Study on Aging: Midlife in the United States. MEASUREMENTS: Sleep quality was assessed by the Pittsburgh Sleep Quality Index and by a 7-day daily diary...
February 2017: Sleep Health
https://www.readbyqxmd.com/read/28346102/phage-display-derived-ligand-for-mucosal-transcytotic-receptor-gp-2-promotes-antigen-delivery-to-m-cells-and-induces-antigen-specific-immune-response
#9
Inam Ullah Khan, Jiansheng Huang, Rui Liu, Jingbo Wang, Jun Xie, Naishuo Zhu
Successful oral immunization depends on efficient delivery of antigens (Ags) to the mucosal immune induction site. Glycoprotein-2 (GP-2) is an integral membrane protein that is expressed specifically on M cells within follicle-associated epithelium (FAE) and serves as transcytotic receptor for luminal Ags. In this study, we selected peptide ligands against recombinant human GP-2 by screening a phage display library and evaluated their interaction with GP-2 in vitro and ex vivo. Selected peptides were conjugated to the C-terminal of enhanced green fluorescence protein (EGFP) and evaluated for their ability to induce an immune response in mice...
February 1, 2017: SLAS Discov
https://www.readbyqxmd.com/read/28346096/a-novel-multiparametric-drug-scoring-method-for-high-throughput-screening-of-3d-multicellular-tumor-spheroids-using-the-celigo-image-cytometer
#10
Scott Cribbes, Sarah Kessel, Scott McMenemy, Jean Qiu, Leo Li-Ying Chan
Three-dimensional (3D) tumor models have been increasingly used to investigate and characterize cancer drug compounds. The ability to perform high-throughput screening of 3D multicellular tumor spheroids (MCTS) can highly improve the efficiency and cost-effectiveness of discovering potential cancer drug candidates. Previously, the Celigo Image Cytometer has demonstrated a novel method for high-throughput screening of 3D multicellular tumor spheroids. In this work, we employed the Celigo Image Cytometer to examine the effects of 14 cancer drug compounds on 3D MCTS of the glioblastoma cell line U87MG in 384-well plates...
January 1, 2017: SLAS Discov
https://www.readbyqxmd.com/read/28345999/variance-associated-with-walking-velocity-during-force-platform-gait-analysis-of-a-heterogeneous-sample-of-clinically-normal-dogs
#11
Alexander M Piazza, Emily E Binversie, Lauren A Baker, Brett Nemke, Susannah J Sample, Peter Muir
OBJECTIVE To determine whether walking at specific ranges of absolute and relative (V*) velocity would aid efficient capture of gait trial data with low ground reaction force (GRF) variance in a heterogeneous sample of dogs. ANIMALS 17 clinically normal dogs of various breeds, ages, and sexes. PROCEDURES Each dog was walked across a force platform at its preferred velocity, with controlled acceleration within 0.5 m/s(2). Ranges in V* were created for height at the highest point of the shoulders (withers; WHV*)...
April 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28345899/ammonia-borane-dehydrogenation-catalyzed-by-%C3%AE%C2%BA-4-ep3-co-h-ep3-e-ch2ch2pph2-3-e-n-p-and-h2-evolution-from-their-interaction-with-nh-acids
#12
Stefano Todisco, Lapo Luconi, Giuliano Giambastiani, Andrea Rossin, Maurizio Peruzzini, Igor E Golub, Oleg A Filippov, Natalia V Belkova, Elena S Shubina
Two Co(I) hydrides containing the tripodal polyphosphine ligand EP3, (κ(4)-EP3)Co(H) [E(CH2CH2PPh2)3; E = N (1), P (2)], have been exploited as ammonia borane (NH3BH3, AB) dehydrogenation catalysts in THF solution at T = 55 °C. The reaction has been analyzed experimentally through multinuclear ((11)B, (31)P{(1)H}, (1)H) NMR and IR spectroscopy, kinetic rate measurements, and kinetic isotope effect (KIE) determination with deuterated AB isotopologues. Both complexes are active in AB dehydrogenation, albeit with different rates and efficiency...
March 27, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28345889/ape1-accelerates-turnover-of-hogg1-by-preventing-retrograde-binding-to-the-abasic-site-product
#13
Alexandre Esadze, Gaddiel Rodriguez, Shannen Lee Cravens, James T Stivers
A major product of oxidative DNA damage is 8-oxoguanine. In humans, 8-oxoguanine DNA Glycosylase (hOGG1) facilitates removal of these lesions, producing an abasic (AP) site in the DNA that is subsequently incised by AP-endonuclease 1 (APE1). APE1 stimulates turnover of several glycosylases by accelerating rate-limiting product release. However, there have been conflicting accounts of whether hOGG1 follows a similar mechanism. In pre-steady state kinetic measurements, we found that addition of APE1 had no effect on the rapid burst phase of 8-oxoguanine excision by hOGG1, but accelerated steady-state turnover (kcat) by ~10-fold...
March 27, 2017: Biochemistry
https://www.readbyqxmd.com/read/28345859/aqueous-nanoparticle-polymer-solar-cells-the-effects-of-surfactant-concentration-and-processing-on-device-performance
#14
Fallon J M Colberts, Martijn M Wienk, René A J Janssen
Polymer solar cells based on PDPP5T and PCBM as donor and acceptor materials have been processed from aqueous nanoparticle miniemulsions. Careful monitoring and optimizing the concentration of free and surface-bound surfactants in the dispersion, by measuring the conductivity and zeta potential, is essential to avoid aggregation of nanoparticles at low concentration and de-wetting of the film at high concentration. The surfactant concentration is crucial for creating reproducible processing conditions that aid in further developing aqueous nanoparticle processed solar cells...
March 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28345773/screening-for-malnutrition-in-hospitalised-older-people-comparison-of-the-mini-nutritional-assessment-with-its-short-form-versions
#15
Elsa Dent, Ian Chapman, Cynthia Piantadosi, Renuka Visvanathan
OBJECTIVE: To determine how well the Mini Nutritional Assessment (MNA) Short Form (MNA-SF) performed as a nutritional screening tool when calf circumference replaced body mass index (BMI) as the included anthropometric measurement. METHODS: A total of 100 patients ≥70 years were recruited from a Geriatric Evaluation and Management Unit. RESULTS: Mean age of patients was 85.2 (6.1) years. By the full MNA, 40% of patients were malnourished...
March 27, 2017: Australasian Journal on Ageing
https://www.readbyqxmd.com/read/28345655/large-electrocaloric-effect-in-relaxor-ferroelectric-and-antiferroelectric-lanthanum-doped-lead-zirconate-titanate-ceramics
#16
Biao Lu, Peilian Li, Zhenhua Tang, Yingbang Yao, Xingsen Gao, Wolfgang Kleemann, Sheng-Guo Lu
Both relaxor ferroelectric and antiferroelectric materials can individually demonstrate large electrocaloric effects (ECE). However, in order to further enhance the ECE it is crucial to find a material system, which can exhibit simultaneously both relaxor ferroelectric and antiferroelectric properties, or easily convert from one into another in terms of the compositional tailoring. Here we report on a system, in which the structure can readily change from antiferroelectric into relaxor ferroelectric and vice versa...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28345548/polyglycolic-acid-fibrous-scaffold-improving-endothelial-cell-coating-and-vascularization-of-islet
#17
Yang Li, Ping Fan, Xiao-Ming Ding, Xiao-Hui Tian, Xin-Shun Feng, Hang Yan, Xiao-Ming Pan, Pu-Xun Tian, Jin Zheng, Chen-Guang Ding, Wu-Jun Xue
BACKGROUND: Improving islet graft revascularization has become a crucial task for prolonging islet graft survival. Endothelial cells (ECs) are the basis of new microvessels in an isolated islet, and EC coating has been demonstrated to improve the vascularization and survival of an islet. However, the traditional method of EC coating of islets has low efficiency in vitro. This study was conducted to evaluate the effect of a polyglycolic acid (PGA) scaffold on the efficiency of islet coating by ECs and the angiogenesis in the coated islet graft...
April 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28345385/activation-of-5-ht1a-receptors-in-the-rat-dorsomedial-hypothalamus-inhibits-stress-induced-activation-of-the-hypothalamic-pituitary-adrenal-axis
#18
Christopher E Stamper, James E Hassell, Adam J Kapitz, Kenneth J Renner, Miles Orchinik, Christopher A Lowry
Acute activation of the hypothalamic-pituitary-adrenal (HPA) axis, leading to the release of corticosteroid hormones into the circulation, is an adaptive response to perceived threats. Persistent activation of the HPA axis can lead to impaired physiological or behavioral function with maladaptive consequences. Thus, efficient control and termination of stress responses is essential for well-being. However, inhibitory control mechanisms governing the HPA axis are poorly understood. Previous studies suggest that serotonergic systems, acting within the medial hypothalamus, play an important role in inhibitory control of stress-induced HPA axis activity...
March 27, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28345030/wearable-disposable-sweat-based-glucose-monitoring-device-with-multistage-transdermal-drug-delivery-module
#19
Hyunjae Lee, Changyeong Song, Yong Seok Hong, Min Sung Kim, Hye Rim Cho, Taegyu Kang, Kwangsoo Shin, Seung Hong Choi, Taeghwan Hyeon, Dae-Hyeong Kim
Electrochemical analysis of sweat using soft bioelectronics on human skin provides a new route for noninvasive glucose monitoring without painful blood collection. However, sweat-based glucose sensing still faces many challenges, such as difficulty in sweat collection, activity variation of glucose oxidase due to lactic acid secretion and ambient temperature changes, and delamination of the enzyme when exposed to mechanical friction and skin deformation. Precise point-of-care therapy in response to the measured glucose levels is still very challenging...
March 2017: Science Advances
https://www.readbyqxmd.com/read/28344808/safety-tumor-trafficking-and-immunogenicity-of-chimeric-antigen-receptor-car-t-cells-specific-for-tag-72-in-colorectal-cancer
#20
Kristen M Hege, Emily K Bergsland, George A Fisher, John J Nemunaitis, Robert S Warren, James G McArthur, Andy A Lin, Jeffrey Schlom, Carl H June, Stephen A Sherwin
BACKGROUND: T cells engineered to express chimeric antigen receptors (CARs) have established efficacy in the treatment of B-cell malignancies, but their relevance in solid tumors remains undefined. Here we report results of the first human trials of CAR-T cells in the treatment of solid tumors performed in the 1990s. METHODS: Patients with metastatic colorectal cancer (CRC) were treated in two phase 1 trials with first-generation retroviral transduced CAR-T cells targeting tumor-associated glycoprotein (TAG)-72 and including a CD3-zeta intracellular signaling domain (CART72 cells)...
2017: Journal for Immunotherapy of Cancer
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