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https://www.readbyqxmd.com/read/28719888/inhibition-of-single-routes-of-intracellular-signaling-is-not-sufficient-to-neutralize-the-biphasic-disturbance-of-a-retinal-endothelial-cell-barrier-induced-by-vegf-a165
#1
Heidrun L Deissler, Gerhard K Lang, Gabriele E Lang
BACKGROUND/AIMS: Hallmark of diabetic macular edema is the enhanced permeability of retinal endothelial cells (REC) induced by vascular endothelial growth factor (VEGF-A165), which acts through activating specific receptors. To improve the predictability of inhibitors' potentials to block harmful effects of VEGF-A165, we investigated if its signaling pathways triggered in REC are redundant. METHODS: Immortalized bovine REC monolayers were treated with inhibitors specific for various protein kinases in combination with VEGF-A165...
July 18, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28719852/rapid-gamma-spectrometric-analysis-of-soil-samples-after-radioactive-fallout-using-a-conjugate-view-technique
#2
M Isaksson, M Fahlström, N Ossipova, K Rosén
A method for fast determination of the activity in soil samples by measuring a fresh soil core sample from both ends with an HPGe-detector is proposed. The method was tested by simulations, as well as by measurements on spiked soil samples. Both simulations and measurements showed that the geometrical mean of the count rates when the sample is measured twice, with the bottom and the top end, respectively, facing the detector closely resembles the count rate from a measurement on a homogenized sample. Therefore, an efficiency calibration for homogenized samples could be used even if the activity is highly inhomogeneous in the soil core, as is the case with fresh fallout...
July 15, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28719651/link-prediction-on-twitter
#3
Sanda Martinčić-Ipšić, Edvin Močibob, Matjaž Perc
With over 300 million active users, Twitter is among the largest online news and social networking services in existence today. Open access to information on Twitter makes it a valuable source of data for research on social interactions, sentiment analysis, content diffusion, link prediction, and the dynamics behind human collective behaviour in general. Here we use Twitter data to construct co-occurrence language networks based on hashtags and based on all the words in tweets, and we use these networks to study link prediction by means of different methods and evaluation metrics...
2017: PloS One
https://www.readbyqxmd.com/read/28719216/exploring-ultimate-water-capillary-evaporation-in-nanoscale-conduits
#4
Yinxiao Li, Mohammad Amin Alibakhshi, Yihong Zhao, Chuanhua Duan
Capillary evaporation in nanoscale conduits is an efficient heat/mass transfer strategy that has been widely utilized by both nature and mankind. Despite its broad impact, the ultimate transport limits of capillary evaporation in nanoscale conduits, governed by the evaporation/condensation kinetics at the liquid-vapor interface, have remained poorly understood. Here we report experimental study of the kinetic limits of water capillary evaporation in 2-D nanochannels using a novel hybrid channel design. Our results show that the kinetic-limited evaporation fluxes break down the limits predicated by the classical Hertz-Knudsen equation by an order of magnitude, reaching values up to 37...
July 18, 2017: Nano Letters
https://www.readbyqxmd.com/read/28718808/beta-palmitate-improves-bone-length-and-quality-during-catch-up-growth-in-young-rats
#5
Meytal Bar-Maisels, Yankel Gabet, Raanan Shamir, Sahar Hiram-Bab, Metsada Pasmanik-Chor, Moshe Phillip, Fabiana Bar-Yoseph, Galia Gat-Yablonski
Palmitic acid (PA) is the most abundant saturated fatty acid in human milk, where it is heavily concentrated in the sn-2-position (termed beta palmitate, BPA) and as such is conserved in all women, regardless of their diet or ethnicity, indicating its physiological and metabolic importance. We hypothesized that BPA improves the efficiency of nutrition-induced catch up growth as compared to sn-1,3 PA, which is present in vegetable oil. Pre-pubertal male rats were subjected to a 17 days food restriction followed by re-feeding for nine days with 1,3 PA or BPA-containing diets...
July 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28718392/efficient-body-fat-estimation-using-multistage-pair-ranked-set-sampling
#6
M Mahdizadeh, Ehsan Zamanzade
Rank-based sampling methods are applicable in settings where precise measurements are expensive, but small sets of units can be accurately ranked at negligible cost. This article introduces one such a design, called multistage pair ranked set sampling. It mitigates ranking burden associated with a competitor scheme, namely multistage ranked set sampling. The mean estimator in multistage pair ranked set sampling is unbiased, and under perfect rankings has variance no larger than its simple random sampling counterpart...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/28718293/functional-design-of-dielectric-metal-dielectric-based-thin-film-encapsulation-with-heat-transfer-and-flexibility-for-flexible-displays
#7
Jeong Hyun Kwon, Seungyeop Choi, Yongmin Jeon, Hyuncheol Kim, Ki Soo Chang, Kyung Cheol Choi
In this study, a new and efficient dielectric-metal-dielectric-based thin-film encapsulation (DMD-TFE) with an inserted Ag thin film is proposed to guarantee the reliability of flexible displays by improving the barrier properties, mechanical flexibility, and heat dissipation, considered as essential requirements for OLED encapsulation. The DMD-TFE, which is composed of Al2O3, Ag, and a silica nanoparticle-embedded sol-gel hybrid nanocomposite, shows a water vapor transmission rate of 8.70 × 10-6 g/m2/day and good mechanical reliability at a bending radius of 30 mm corresponding to 0...
July 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28718074/advances-in-imaging-instrumentation-for-nuclear-cardiology
#8
Jae Sung Lee, Gil Kovalski, Tali Sharir, Dong Soo Lee
Advances in imaging instrumentation and technology have greatly contributed to nuclear cardiology. Dedicated cardiac SPECT cameras incorporating novel, highly efficient detector, collimator, and system designs have emerged with the expansion of nuclear cardiology. Solid-state radiation detectors incorporating cadmium zinc telluride, which directly convert radiation to electrical signals and yield improved energy resolution and spatial resolution and enhanced count sensitivity geometries, are increasingly gaining favor as the detector of choice for application in dedicated cardiac SPECT systems...
July 17, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28718051/coronary-heart-disease-preoperative-gesture-interactive-diagnostic-system-based-on-augmented-reality
#9
Yi-Bo Zou, Yi-Min Chen, Ming-Ke Gao, Quan Liu, Si-Yu Jiang, Jia-Hui Lu, Chen Huang, Ze-Yu Li, Dian-Hua Zhang
Coronary heart disease preoperative diagnosis plays an important role in the treatment of vascular interventional surgery. Actually, most doctors are used to diagnosing the position of the vascular stenosis and then empirically estimating vascular stenosis by selective coronary angiography images instead of using mouse, keyboard and computer during preoperative diagnosis. The invasive diagnostic modality is short of intuitive and natural interaction and the results are not accurate enough. Aiming at above problems, the coronary heart disease preoperative gesture interactive diagnostic system based on Augmented Reality is proposed...
August 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28718028/predicting-attenuation-of-solar-radiation-uv-b-uv-a-and-par-in-waste-stabilization-ponds-under-sahelian-climatic-conditions
#10
Ynoussa Maiga, Joseph Wethé, Aboubakar Sidiki Ouattara, Alfred S Traoré
Because of its importance in pathogen removal and algal productivity in waste stabilization ponds, sunlight penetration was measured in microcosms and in situ under Sahelian climatic conditions. The different wavelengths were detected using a submersible radiometer equipped with three sensors: UV-B (311 nm), UV-A (369 nm) and photosynthetically available radiation (PAR, 400-700 nm). UV-B was more attenuated than UV-A and PAR. Facultative pond was more light-attenuating than maturation pond. The mean euphotic depths for UV-B were 0...
July 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28717902/fusion-of-heart-rate-variability-and-pulse-rate-variability-for-emotion-recognition-using-lagged-poincare-plots
#11
Atefeh Goshvarpour, Ataollah Abbasi, Ateke Goshvarpour
Designing an efficient automatic emotion recognition system based on physiological signals has attracted great interests within the research of human-machine interactions. This study was aimed to classify emotional responses by means of a simple dynamic signal processing technique and fusion frameworks. The electrocardiogram and finger pulse activity of 35 participants were recorded during rest condition and when subjects were listening to music intended to stimulate certain emotions. Four emotion categories, including happiness, sadness, peacefulness, and fear were chosen...
July 17, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28717415/chronic-antiepileptic-drug-use-and-functional-network-efficiency-a-functional-magnetic-resonance-imaging-study
#12
Tamar M van Veenendaal, Dominique M IJff, Albert P Aldenkamp, Richard H C Lazeron, Paul A M Hofman, Anton J A de Louw, Walter H Backes, Jacobus F A Jansen
AIM: To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug (AED) treatment. METHODS: The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A "low risk" category (lamotrigine or levetiracetam, n = 16), an "intermediate risk" category (carbamazepine, oxcarbazepine, phenytoin, or valproate, n = 34) and a "high risk" category (topiramate, n = 5)...
June 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/28717384/accelerating-root-system-phenotyping-of-seedlings-through-a-computer-assisted-processing-pipeline
#13
Lionel X Dupuy, Gladys Wright, Jacqueline A Thompson, Anna Taylor, Sebastien Dekeyser, Christopher P White, William T B Thomas, Mark Nightingale, John P Hammond, Neil S Graham, Catherine L Thomas, Martin R Broadley, Philip J White
BACKGROUND: There are numerous systems and techniques to measure the growth of plant roots. However, phenotyping large numbers of plant roots for breeding and genetic analyses remains challenging. One major difficulty is to achieve high throughput and resolution at a reasonable cost per plant sample. Here we describe a cost-effective root phenotyping pipeline, on which we perform time and accuracy benchmarking to identify bottlenecks in such pipelines and strategies for their acceleration...
2017: Plant Methods
https://www.readbyqxmd.com/read/28717288/cone-beam-computed-tomographic-analysis-of-the-course-and-position-of-mandibular-canal
#14
Hooman Khorshidi, Saeed Raoofi, Janan Ghapanchi, Shoaleh Shahidi, Maryam Paknahad
PURPOSE: Estimation of the relative position of infra alveolar nerve (IAN) canal and its relation to the mandibular anatomical landmarks can be clinically useful in minimizing the risk of surgery complications such as neurosensory disturbances that may occur after invasive mandibular surgical procedures. The purpose of the present study was to investigate the anatomic location and radiographic course of the mandibular canal compared to anatomic landmarks on CBCT and to discuss its clinical significance and also to determine the possible correlations between the mandibular position and the age of the patients...
September 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28717249/spectral-characteristics-of-cotton-seeds-treated-by-a-dielectric-barrier-discharge-plasma
#15
Xing-Quan Wang, Ren-Wu Zhou, Gerard de Groot, Kateryna Bazaka, Anthony B Murphy, Kostya Ken Ostrikov
Cold atmospheric plasma has recently emerged as a simple, low-cost and efficient physical method for inducing significant biological responses in seeds and plants without the use of traditional, potentially environmentally-hazardous chemicals, fungicides or hormones. While the beneficial effects of plasma treatment on seed germination, disease resistance and agricultural output have been reported, the mechanisms that underpin the observed biological responses are yet to be fully described. This study employs Fourier Transform Infrared (FTIR) spectroscopy and emission spectroscopy to capture chemical interactions between plasmas and seed surfaces with the aim to provide a more comprehensive account of plasma-seed interactions...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717042/modeling-the-kinetics-of-the-permeation-of-antibacterial-agents-into-growing-bacteria-and-its-interplay-with-efflux
#16
Wright W Nichols
A mathematical model of the passive permeation of a novel solute into bacteria is developed that explicitly accounts for intracellular dilution through growth. A bacterial cell envelope permeability coefficient of >10(-8) cm(2)s(-1) approx., is predicted to ensure passive permeation into rapidly replicating bacterial cells. The relative importance of the permeability coefficients of the cytoplasmic and outer membranes of Gram-negative bacteria in determining the overall envelope permeability coefficient is analyzed quantitatively...
July 17, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28716758/oral-delivery-of-vancomycin-by-tetraether-lipid-liposomes
#17
Philipp Uhl, Silvia Pantze, Philip Storck, Johannes Parmentier, Dominik Witzigmann, Götz Hofhaus, Jörg Huwyler, Walter Mier, Gert Fricker
Despite the outstanding progress in modern medicine, the oral delivery of peptide drugs is limited until today due to their instability in the gastrointestinal tract and low mucosa penetration. To overcome these hurdles, liposomes containing the specific tetraether lipid GCTE (glycerylcaldityltetraether lipid) were examined. For this purpose, the glycopeptide antibiotic vancomycin was used as model substance and liposomes were prepared by DAC (dual assymetric centrifugation). These liposomes showed a size and polydispersity index comparable to standard liposomes...
July 14, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28716680/three-dimensional-adiabatic-inversion-recovery-prepared-ultrashort-echo-time-cones-3d-ir-ute-cones-imaging-of-cortical-bone-in-the-hip
#18
Amin Nazaran, Michael Carl, Yajun Ma, Saeed Jerban, Yanchun Zhu, Xing Lu, Jiang Du, Eric Y Chang
PURPOSE: We present three-dimensional adiabatic inversion recovery prepared ultrashort echo time Cones (3D IR-UTE-Cones) imaging of cortical bone in the hip of healthy volunteers using a clinical 3T scanner. METHODS: A 3D IR-UTE-Cones sequence, based on a short pulse excitation followed by a 3D Cones trajectory, with a nominal TE of 32μs, was employed for high contrast morphological imaging of cortical bone in the hip of heathy volunteers. Signals from soft tissues such as muscle and marrow fat were suppressed via adiabatic inversion and signal nulling...
July 14, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28716122/systematic-evaluation-of-oligodeoxynucleotide-binding-and-hybridization-to-modified-multi-walled-carbon-nanotubes
#19
Anika Kaufmann, Silke Hampel, Christiane Rieger, David Kunhardt, Darja Schendel, Susanne Füssel, Bernd Schwenzer, Kati Erdmann
BACKGROUND: In addition to conventional chemotherapeutics, nucleic acid-based therapeutics like antisense oligodeoxynucleotides (AS-ODN) represent a novel approach for the treatment of bladder cancer (BCa). An efficient delivery of AS-ODN to the urothelium and then into cancer cells might be achieved by the local application of multi-walled carbon nanotubes (MWCNT). In the present study, pristine MWCNT and MWCNT functionalized with hydrophilic moieties were synthesized and then investigated regarding their physicochemical characteristics, dispersibility, biocompatibility, cellular uptake and mucoadhesive properties...
July 17, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28716030/modeling-de-novo-granulation-of-anaerobic-sludge
#20
Anna Doloman, Honey Varghese, Charles D Miller, Nicholas S Flann
BACKGROUND: A unique combination of mechanical, physiochemical and biological forces influences granulation during processes of anaerobic digestion. Understanding this process requires a systems biology approach due to the need to consider not just single-cell metabolic processes, but also the multicellular organization and development of the granule. RESULTS: In this computational experiment, we address the role that physiochemical and biological processes play in granulation and provide a literature-validated working model of anaerobic granule de novo formation...
July 17, 2017: BMC Systems Biology
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