keyword
https://read.qxmd.com/read/38511329/an-aquaporin-and-an-aquaglyceroporin-have-roles-in-low-temperature-adaptation-of-mosquitoes-anopheles-sinensis
#21
JOURNAL ARTICLE
Yong-Qiao Zhao, Yi-Ying Tang, Ju-Ping Hu, Yu-Zheng Huang, Kai Wan, Mei-Hua Zhang, Ju-Lin Li, Guo-Ding Zhu, Jian-Xia Tang
Mosquitoes (Anopheles sinensis), widely geographically distributed in Asia including China, are the primary vector of the malaria parasite Plasmodium vivax and other parasitic diseases such as Malayan filariasis. An. sinensis can survive through low winter temperatures. Aquaporin channels are found in all life forms, where they facilitate environmental adaptation by allowing rapid trans-cellular movement of water (classical aquaporins) or water and solutes such as glycerol (aquaglyceroporins). Here, we identified and characterized 2 aquaporin (AQP) homologs in An...
March 21, 2024: Insect Science
https://read.qxmd.com/read/38498694/aqp4-darpin1-a-chimeric-antigen-based-on-scaffold-protein-darpin-for-efficient-detection-of-aqp4-igg-in-nmosd
#22
JOURNAL ARTICLE
Xiaofei Wang, Shubei Ma, Ying Bai, Xinyang Wu, Fangling Ji, Lingyun Jia
AQP4-IgG is an autoantibody associated with neuromyelitis optica spectroscopic disorder (NMOSD), a central nervous system inflammatory disease that requires early diagnosis and treatment. We designed two fusion proteins, AQP4-DARPin1 and AQP4-DARPin2, comprising the complete antigenic epitopes of aquaporin-4 (AQP4) and the constant region of the scaffold protein DARPin. These fusion proteins were expressed and purified from Escherichia coli and coated on microplates to develop an efficient method for detecting AQP4-IgG...
March 18, 2024: Biochemistry
https://read.qxmd.com/read/38498254/maize-multi-omics-reveal-leaf-water-status-controlling-of-differential-transcriptomes-proteomes-and-hormones-as-mechanisms-of-age-dependent-osmotic-stress-response-in-leaves
#23
JOURNAL ARTICLE
Liangjie Niu, Wenkang Wang, Yingxue Li, Xiaolin Wu, Wei Wang
Drought-induced osmotic stress severely affects the growth and yield of maize. However, the mechanisms underlying the different responses of young and old maize leaves to osmotic stress remain unclear. To gain a systematic understanding of age-related stress responses, we compared osmotic-stress-induced changes in maize leaves of different ages using multi-omics approaches. After short-term osmotic stress, old leaves suffered more severe water deficits than young leaves. The adjustments of transcriptomes, proteomes, and hormones in response to osmotic stress were more dynamic in old leaves...
March 18, 2024: Stress Biol
https://read.qxmd.com/read/38498138/correction-to-mycorrhizosphere-bacteria-inhibit-chromium-uptake-and-phytotoxicity-by-regulating-proline-metabolism-antioxidant-defense-system-and-aquaporin-gene-expression-in-tomato
#24
Tariq Shah, Zeeshan Khan, Tahani Awad Alahmadi, Ayesha Imran, Muhammad Asad, Shah Rukh Khan, Mohammad Javed Ansari
No abstract text is available yet for this article.
March 18, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38493662/differences-in-mineral-and-osmotic-balances-enhance-zinc-translocation-in-an-aquaporin-overexpressing-poplar
#25
JOURNAL ARTICLE
Andrea Neri, Alessandra Francini, Alessio Giovannelli, Silvia Traversari, Luca Sebastiani
Zinc (Zn) is an essential micronutrient for plants, but it is toxic beyond a certain threshold. Populus alba (L.) 'Villafranca' clone is known for its good tolerance to high Zn concentration compared to other poplar species. A line of this species overexpressing the tonoplast intrinsic aquaporin AQUA1 gene has showed an improved tolerance to Zn excess in comparison to the wild-type (wt) line. The aims of this work were to: 1) verify if AQUA1 plants can uptake Zn more efficiently after a longer period of exposure; 2) evaluate if a higher Zn uptake in transgenic lines can have negative effects; 3) assess Zn competing elements (iron and manganese), soluble sugars, osmolytes, and potassium to investigate differences in water and osmotic homeostasis between lines...
March 11, 2024: Plant Physiology and Biochemistry: PPB
https://read.qxmd.com/read/38492911/aquaporine-4-inhibition-attenuates-pentylentetrazole-induced-behavioral-seizures-and-cognitive-impairments-in-kindled-rats
#26
JOURNAL ARTICLE
Fatemeh Rostami, Ali Jaafari Suha, Mahyar Janahmadi, Narges Hosseinmardi
Epilepsy is a neurological condition distinguished by recurrent and unexpected seizures. Astrocytic channels and transporters are essential for maintaining normal neuronal functionality. The astrocytic water channel aquaporin-4 (AQP4), which plays a pivotal role in regulating water homeostasis, is a potential target for epileptogenesis. In present study, we examined the effect of different doses (10, 50, 100 μM and 5 mM) of AQP4 inhibitor, 2-nicotinamide-1, 3, 4-thiadiazole (TGN-020), during kindling acquisition, on seizure parameters and seizure-induced cognitive impairments...
March 14, 2024: Physiology & Behavior
https://read.qxmd.com/read/38492884/ginkgolide-b-can-alleviate-spinal-glymphatic-system-dysfunction-and-provide-neuroprotection-in-pdn-rats-by-inhibiting-matrix-metalloproteinase-9
#27
JOURNAL ARTICLE
Jiang Li, Shuaiying Jia, Yuehan Song, Wenmei Xu, Jingyan Lin
The glymphatic system plays a crucial role in maintaining optimal central nervous system (CNS) function by facilitating the removal of metabolic wastes. Aquaporin-4 (AQP4) protein, predominantly located on astrocyte end-feet, is a key pathway for metabolic waste excretion. β-Dystroglycan (β-DG) can anchor AQP4 protein to the end-feet membrane of astrocytes and can be cleaved by matrix metalloproteinase (MMP)-9 protein. Studies have demonstrated that hyperglycemia upregulates MMP-9 expression in the nervous system, leading to neuropathic pain...
March 14, 2024: Neuropharmacology
https://read.qxmd.com/read/38489945/cerebrospinal-fluid-eosinophils-in-pediatric-myelin-oligodendrocyte-glycoprotein-antibody-associated-disease
#28
JOURNAL ARTICLE
Alexandra B Kornbluh, Victor M Campano, Claire Har, Pallavi Dwivedi, William Suslovic, Leigh Sepeta, Ilana Kahn
BACKGROUND: Eosinophils in cerebrospinal fluid (CSF) are an uncommon finding most often associated with parasitic infections, but have also been described in some neuroinflammatory disorders. Eosinophilic infiltration is not thought to be a typical feature of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). We aim to describe the rate of CSF eosinophil positivity in a cohort of pediatric MOGAD patients. METHODS: Single-center retrospective chart review of pediatric MOGAD patients...
March 9, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38488890/clinical-profile-and-challenges-faced-in-the-management-of-optic-neuritis-the-indian-scenario
#29
JOURNAL ARTICLE
Madhurima Kaushik, Virna Mahesh Shah, Sharmila Murugesan, Karthik Kumar Mani, Shriram Vardharajan
PURPOSE: Optic neuritis (ON) is a relatively common ophthalmic disease that has recently received renewed attention owing to immunological breakthroughs. We studied the profile of patients with ON with special reference to antibody-mediated ON and the challenges faced in its management. METHODS: Case records of patients with ON presenting to a tertiary eye-care center in South India were analyzed. Data on demographics, presenting visual acuity (VA), clinical features, seropositivity for aquaporin-4 immunoglobulin G (AQP4-IgG) and myelin oligodendrocyte glycoprotein immunoglobulin G (MOG-IgG), details of magnetic resonance imaging (MRI) of orbits and brain, and treatment were collected...
March 15, 2024: International Ophthalmology
https://read.qxmd.com/read/38479595/cinnamaldehyde-lactulose-combination-therapy-alleviates-thioacetamide-induced-hepatic-encephalopathy-via-targeting-p2x7r-mediated-nlrp3-inflammasome-signaling
#30
JOURNAL ARTICLE
Al Shaima G Abd El Salam, Nesma A Abd Elrazik
AIMS: Cinnamaldehyde (CA), the main active constituent of cinnamon oil, is reported to have neuroprotective effects. However, the potential benefits of CA for brain protection in hepatic encephalopathy (HE) are still not understood. Thus, the present study investigates the possible ameliorative effect of CA (70 mg/kg/day, I.P.) either alone or in combination with lactulose (Lac) (5.3 g/kg/day, oral) against thioacetamide (TAA)-induced hepatic encephalopathy in rats. MATERIALS AND METHODS: For induction of HE, TAA (200 mg/kg) was intraperitoneally administered for 1 week at alternative days...
March 11, 2024: Life Sciences
https://read.qxmd.com/read/38479079/cmopip1-4-confers-drought-tolerance-in-pumpkin-by-altering-hydrogen-sulfide-signaling
#31
JOURNAL ARTICLE
Hamza Sohail, Iqra Noor, Mirza Hasanuzzaman, Shouyu Geng, Lanxing Wei, Muhammad Azher Nawaz, Yuan Huang, Li Yang, Zhilong Bie
Drought is a major limiting factor for the growth and development of pumpkins. Plasma membrane intrinsic proteins (PIPs) are major water channels that play a crucial role in the regulation of cellular water status and solute trafficking during drought conditions. CmoPIP1-4 is a plasma membrane-localized protein that is significantly upregulated in roots and leaves under drought-stress conditions. In this study, the overexpression of CmoPIP1-4 enhances drought resistance in yeast. In contrast, CRISPR-mediated CmoPIP1-4 knockout in pumpkin roots increased drought sensitivity...
March 5, 2024: Plant Physiology and Biochemistry: PPB
https://read.qxmd.com/read/38479046/impact-of-rituximab-treatment-regime-on-time-to-relapse-in-aquaporin-4-antibody-positive-neuromyelitis-optica-spectrum-disorder
#32
JOURNAL ARTICLE
Moneeb Nasir, Luke Hone, Emma Tallantyre, Patricia Kelly, Maria Isabel Leite, Neil Robertson, Jonathan Bestwick, Saif Huda, Jacqueline Palace, Ruth Dobson
BACKGROUND: Aquaporin-4 (AQP4) antibody associated neuromyelitis optica (NMOSD) requires long-term immunosuppression. Rituximab is increasingly used worldwide, however the optimal regime is not established. METHODS: We retrospectively examined different rituximab regimens in AQP4-NMOSD. Standard monotherapy (SM; 6 monthly infusions), SM plus oral steroids (SM+S), extended interval dosing (EID; guided by CD19 repopulation) and EID with oral steroids (EID+S) were compared...
March 7, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38479045/role-of-c5-inhibitors-in-neuromyelitis-optica-spectrum-disorders-with-seropositive-anti-aquaporin-4-antibody-a-systematic-review-and-meta-analysis
#33
REVIEW
Seraj Makkawi, Hassan K Salamatullah, Ahmed Alkhiri, Dania E Faidah, Lena M Afif, Jawad I Bukhari, Ahmad Abulaban, Yaser Al Malik, Michael Levy
BACKGROUND: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disorder characterized by relapses of inflammation and demyelination primarily affecting the optic nerve and the spinal cord. C5 complement inhibition is an effective therapeutic approach in the treatment of NMOSD. In this systematic review and meta-analysis, we aimed to determine the role of C5 inhibitors in the treatment of patients with seropositive anti-aquaporin-4 antibody (AQP4+IgG) NMOSD. METHODS: This systematic review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline...
March 1, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38478568/field-application-of-de-novo-transcriptomic-analysis-to-evaluate-the-effects-of-sublethal-freshwater-salinization-on-gasterosteus-aculeatus-in-urban-streams
#34
JOURNAL ARTICLE
Camilo Escobar-Sierra, Kathrin P Lampert
Freshwater salinization poses global challenges for aquatic organisms inhabiting urban streams, impacting their physiology and ecology. However, current salinization research predominantly focuses on mortality endpoints in limited model species, overlooking the sublethal effects on a broader spectrum of organisms and the exploration of adaptive mechanisms and pathways under natural field conditions. To address these gaps, we conducted high-throughput sequencing transcriptomic analysis on the gill tissue of the euryhaline fish Gasterosteus aculeatus, investigating its molecular response to salinity stress in the highly urbanized river Boye, Germany...
2024: PloS One
https://read.qxmd.com/read/38477414/expression-and-functional-analysis-of-a-recombinant-aquaporin-z-from-antarctic-pseudomonas-sp-ams3
#35
JOURNAL ARTICLE
S Balakrishnan, R N Z R A Rahman, N D M Noor, W Latip, M S M Ali
Aquaporin (AQP) is a water channel protein from the family of transmembrane proteins which facilitates the movement of water across the cell membrane. It is ubiquitous in nature, however the understanding of the water transport mechanism, especially for AQPs in microbes adapted to low temperatures, remains limited. AQP also has been recognized for its ability to be used for water filtration, but knowledge of the biochemical features necessary for its potential applications in industrial processes has been lacking...
March 13, 2024: Proteins
https://read.qxmd.com/read/38476871/homeostatic-status-of-thyroid-hormones-and-brain-water-movement-as-determinant-factors-in-biology-of-cerebral-gliomas-a-pilot-study-using-a-bioinformatics-approach
#36
JOURNAL ARTICLE
Carmelita Bastos Mendes, Lanni Sarmento da Rocha, Carlos Alberto de Carvalho Fraga, Adriana Ximenes-da-Silva
INTRODUCTION: The expression and localization of the water channel transporters, aquaporins (AQPs), in the brain are substantially modified in gliomas during tumorigenesis, cell migration, edema formation, and resolution. We hypothesized that the molecular changes associated with AQP1 and AQP4 in the brain may potentially be anticancer therapeutic targets. To test this hypothesis, a bioinformatics analysis of publicly available data from international consortia was performed. METHODS: We used RNA-seq as an experimental strategy and identified the number of differential AQP1 and AQP4 transcript expressions in glioma tissue compared to normal brain tissue...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38474310/early-increase-in-blood-brain-barrier-permeability-in-a-murine-model-exposed-to-fifteen-days-of-intermittent-hypoxia
#37
JOURNAL ARTICLE
Frederic Roche, Anne Briançon-Marjollet, Maurice Dematteis, Marie Baldazza, Brigitte Gonthier, Frederique Bertholon, Nathalie Perek, Jean-Louis Pépin
Obstructive sleep apnea (OSA) is characterized by intermittent repeated episodes of hypoxia-reoxygenation. OSA is associated with cerebrovascular consequences. An enhanced blood-brain barrier (BBB) permeability has been proposed as a marker of those disorders. We studied in mice the effects of 1 day and 15 days intermittent hypoxia (IH) exposure on BBB function. We focused on the dorsal part of the hippocampus and attempted to identify the molecular mechanisms by combining in vivo BBB permeability (Evans blue tests) and mRNA expression of several junction proteins (zona occludens (ZO-1,2,3), VE-cadherin, claudins (1,5,12), cingulin) and of aquaporins (1,4,9) on hippocampal brain tissues...
March 6, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473914/application-of-aquaporins-as-markers-in-forensic-pathology-a-systematic-review-of-the-literature
#38
REVIEW
Letizia Alfieri, Angelo Montana, Paolo Frisoni, Stefano D'Errico, Margherita Neri
The study of aquaporins (AQPs) in various forensic fields has offered a promising horizon in response to the need to have reliable elements for the identification of the manner of death and for the individuation of forensic markers for the timing of lesions and vitality of injury. In the literature, various tissues have been studied; the most investigated are the lungs, brain, kidneys, skin, and blood vessels. A systematic literature review on PubMed following PRISMA 2020 guidelines enabled the identification of 96 articles...
February 25, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38467563/effect-of-heat-stress-on-the-hypothalamic-expression-profile-of-water-homeostasis-associated-genes-in-low-and-high-water-efficient-chicken-lines
#39
JOURNAL ARTICLE
Loujain Aloui, Elizabeth S Greene, Travis Tabler, Kentu Lassiter, Kevin Thompson, Walter G Bottje, Sara Orlowski, Sami Dridi
With climate change, selection for water efficiency and heat resilience are vitally important. We undertook this study to determine the effect of chronic cyclic heat stress (HS) on the hypothalamic expression profile of water homeostasis-associated markers in high (HWE)- and low (LWE)-water efficient chicken lines. HS significantly elevated core body temperatures of both lines. However, the amplitude was higher by 0.5-1°C in HWE compared to their LWE counterparts. HWE line drank significantly less water than LWE during both thermoneutral (TN) and HS conditions, and HS increased water intake in both lines with pronounced magnitude in LWE birds...
March 2024: Physiological Reports
https://read.qxmd.com/read/38465340/aquaporin-8-promotes-human-dermal-fibroblasts-to-counteract-hydrogen-peroxide-induced-oxidative-damage-a-novel-target-for-management-of-skin-aging
#40
JOURNAL ARTICLE
Shu-Hsiang Liu, Wei-Chun Lin, En-Chih Liao, Yung-Feng Lin, Ching-Shuen Wang, Sheng-Yang Lee, Dee Pei, Chun-Hsien Hsu
The skin is subjected to various external factors that contribute to aging including oxidative stress from hydrogen peroxide (H2 O2 ). This study investigated the distribution of aquaporin-8 (AQP8), a protein that transports H2 O2 across biological membranes, in skin cells, and its effects in mitigating H2 O2 -induced oxidative damage. Human dermal fibroblasts were treated with increasing concentrations of H2 O2 to evaluate oxidative damage. Cell viability, reactive oxygen species (ROS) generation, and the expression of specific genes associated with skin aging (IL-10, FPR2, COL1A1, KRT19, and Aggrecan) were evaluated and AQP8 expression was assessed via quantitative polymerase chain reaction and western blotting...
2024: Open Life Sciences
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