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triamcinolone acetonide nasal spray

Lee Yee Chong, Karen Head, Claire Hopkins, Carl Philpott, Martin J Burton, Anne G M Schilder
BACKGROUND: This review is one of six looking at the primary medical management options for patients with chronic rhinosinusitis.Chronic rhinosinusitis is common and is characterised by inflammation of the lining of the nose and paranasal sinuses leading to nasal blockage, nasal discharge, facial pressure/pain and loss of sense of smell. The condition can occur with or without nasal polyps. Topical (intranasal) corticosteroids are used with the aim of reducing inflammation in the sinonasal mucosa in order to improve patient symptoms...
April 26, 2016: Cochrane Database of Systematic Reviews
David P Skoner, William E Berger, Sandra M Gawchik, Akbar Akbary, Chunfu Qiu
BACKGROUND: Inadequate designs and conflicting results from previous studies prompted the US Food and Drug Administration to publish guidelines for the design of clinical trials evaluating the effects of orally inhaled and intranasal corticosteroids on the growth of children. This study conformed to these guidelines to evaluate the effect of triamcinolone acetonide aqueous nasal spray (TAA-AQ) on the growth of children with perennial allergic rhinitis (PAR). METHODS: This randomized, double-blind, placebo-controlled, parallel-group, multicenter study evaluated the effect of once-daily TAA-AQ (110 μg) on the growth velocity (GV) of children aged 3-9 years with PAR by using stadiometry at baseline (4-6 months), during treatment (12 months), and at follow-up (2 months)...
February 2015: Pediatrics
George Georges, Kenneth T Kim, Paul Ratner, Nathan Segall, Chunfu Qiu
Intranasal corticosteroids are the most effective medication class for controlling allergic rhinitis (AR) symptoms. However, limited data are available on their effects on basal hypothalamic-pituitary-adrenal (HPA) axis function in children. This study was designed to determine the effect of 6-week triamcinolone acetonide aqueous (TAA-AQ) nasal spray treatment on HPA axis function by measuring 24-hour serum cortisol area under the curve (AUC(0-24h)) in children with AR aged 2-11 years. This phase 4, multicenter, double-blind, placebo-controlled, parallel-group study randomized children with AR to receive TAA-AQ (110 μg, 2-11 years old, or 220 μg, 6-11 years old) or placebo...
March 2014: Allergy and Asthma Proceedings:
Hakan Cincik, Evren Erkul, Dogan Pinar, Osman Ipcioglu, Atila Gungor, Engin Cekin, Adem Cakmak
The aim of this study is to evaluate the effects of intrapolyp, systemic and local corticosteroid treatment modalities on MMP-9 and TIMP-1 level in polyp tissues. This study included 71 patients and five groups. Group A treated with oral methylprednisolone, Group B, treated with topical steroid spray, Group C treated with intralesional triamcinolone acetonide, Group D patients with nasal polyposis who has not given any medication, Group E had surgery for concha bullosa without nasal polyp disease. Samples from group A were collected endoscopically 1 day after treatment was stopped...
August 2013: Indian Journal of Otolaryngology and Head and Neck Surgery
(no author information available yet)
No abstract text is available yet for this article.
November 11, 2013: Medical Letter on Drugs and Therapeutics
Geng-He Chang, Wen-Hung Wang
During the past three decades intranasal corticosteroid sprays have been proven to be efficient and reasonably safe for the treatment of rhinitis, sinusitis and nasal polyposis. The adverse effects are generally localized and self-limited and rarely systemic or significant. We report an immunocompetent female treated with triamcinolone acetonide nasal spray for chronic rhinitis in whom an intranasal fungal infection with Alternaria species developed three months later. The infection was refractory to topical therapies alone, and was resolved with a combination of systemic and topical antifungal therapy...
November 2013: American Journal of Otolaryngology
Chaweewan Bunnag, Dr Suprihati, De-Yun Wang
OBJECTIVE: To evaluate the medication preference, sensory perceptions and compliance of allergic rhinitis patients after a single administration of three intranasal corticosteroids. STUDY DESIGN AND SUBJECTS: In this double-blind, comparative, crossover study, 364 patients were randomised to receive fluticasone propionate (FP), mometasone furoate (MF) and triamcinolone acetonide (TAA) nasal sprays. Patients completed a preference questionnaire including a product preference and compliance evaluation after administration to determine the acceptability of each product...
2003: Clinical Drug Investigation
Aviram Mizrachi, Gideon Bachar, Eitan Yaniv, Tuvia Hadar, Shlomo Vinker
BACKGROUND: Intranasal steroids are widely used for the treatment of inflammatory diseases of the nose and sinuses such as rhinosinusitis, allergic rhinitis, and nonallergic rhinitis. Along with the general otherwise healthy population, many diabetic patients use intranasal steroids as well. This study was designed to evaluate the adverse effects of long-term treatment with intranasal corticosteroid preparations in diabetic patients. METHODS: The study group included all diabetic patients treated with intranasal steroids for at least 3 months at primary care clinics in Clalit Health Services Central District in Israel in 2002-2007...
September 2012: American Journal of Rhinology & Allergy
A Baccioglu Kavut, F Kalpaklıoğlu
BACKGROUND: The efficacy of corticosteroid has not been thoroughly studied in the treatment of non-allergic rhinitis. This study was designed to compare the efficacy of nasal corticosteroid in patients with allergic rhinitis (AR), and non-allergic rhinitis (NAR). METHODS: The efficacy of triamcinolone acetonide nasal spray (TANS) on total nasal symptom scores (TNSS), and nasal peak inspiratory flow rate (nPIFR) was studied in a six-week parallel-group trial of NAR (n: 25), and AR (n: 16) patients...
November 2013: Allergologia et Immunopathologia
Burak Kapucu, Engin Cekin, Bulent Evren Erkul, Hakan Cincik, Atila Gungor, Ufuk Berber
OBJECTIVE: The purpose of this study was to compare the apoptotic responses to systemic, topical, and intrapolyp injection of glucocorticoid with no treatment in nasal polyps. STUDY DESIGN: Prospective, randomized controlled study. SETTING: Tertiary training hospital. SUBJECTS AND METHODS: The study was performed on 48 patients with nasal polyposis in the Department of Otorhinolaryngology between 2008 and 2009. Patients were assigned to 1 of 4 groups of 12 patients...
September 2012: Otolaryngology—Head and Neck Surgery
Hui Yao, Ming-Hui Chen, Chunfu Qiu
Allergic rhinitis is an allergic inflammation of the nasal membranes. The symptoms include disorders in nose and eyes. Studies have been carried out on safety and efficacy evaluation of triamcinolone acetonide aqueous nasal spray. To combine the results from different studies, we propose random-coefficient regression models. The properties of the proposed models are examined. The models are compared via the deviance information criterion (DIC), and Bayesian computations are carried out via MCMC sampling. A set of meta-data from nine clinical trials is analyzed in detail via the proposed methodology...
September 2011: Journal of Biopharmaceutical Statistics
Jubo Liu, Liya Liu, Xiang Lu, Gangyi Zhong, Ying Wan, Qiang Li, Zhijian Feng, Xianhua Li, Yichun Hong
OBJECTIVE: To observe the clinical treatment effectiveness of Clarithromycin combined with nasal glucocorticoids for chronic rhinosinusitis (CRS). METHOD: Clarithromycin was 0.25 g a day (the first two weeks was 0.25 g twice a day) and topical Triamcinolone Acetonide Acetate nasal spray was (220 microg/d) once a day. Fifty-six patients were enrolled in our research. Twenty-six patients of CRS without nasal polyps was treated for 12 to 28 weeks (average 16.62 weeks)...
April 2011: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Michael B Gluth, Darren R McDonald, Amy L Weaver, Christopher D Bauch, Charles W Beatty, Laura J Orvidas
OBJECTIVE: To determine the efficacy of intranasal aqueous triamcinolone acetonide in treating the tympanometric signs and symptoms of eustachian tube dysfunction, such as otitis media with effusion and negative middle ear pressure. DESIGN: Randomized, placebo-controlled, double-blind prospective clinical trial. SETTING: Tertiary referral clinic. PATIENTS: Adults (≥18 years) and children (6-17 years) presenting with otitis media with effusion, negative middle ear pressure, or both...
May 2011: Archives of Otolaryngology—Head & Neck Surgery
Adi Rachmiel, Omri Emodi, Edmond Sabo, Dror Aizenbud, Micha Peled
BACKGROUND: The aggressive type lesions of central giant cell granuloma (CGCG) require wide resection that leads to major defects in the jaws. This form of surgical treatment can be particularly disfiguring. A number of alternative non-surgical therapies have been advocated in recent years for the management of the central giant cell granuloma (CGCG). These include calcitonin injections and nasal spray, intralesional steroid injections and subcutaneous interferon injections. MATERIALS AND METHODS: A large central giant cell granuloma aggressive type lesion in the mandible of a 24-year-old patient was treated successfully by intralesional injection of corticosteroid and nasal spray calcitonin that was followed by curettage with peripheral ostectomy with preservation of the continuity of the mandible and the teeth...
April 2012: Journal of Cranio-maxillo-facial Surgery
Isabela Costa César, Ricardo Martins Duarte Byrro, Fabiana Fernandes de Santana e Silva Cardoso, Iram Moreira Mundim, Leonardo de Souza Teixeira, Weidson Carlo de Sousa, Sandro Antônio Gomes, Karini Bruno Bellorio, Juliana Machado Brêtas, Gerson Antônio Pianetti
A liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) method for the quantitation of triamcinolone in human plasma after nasal spray application was developed and validated. Betamethasone was used as internal standard (IS). The analytes were extracted by a liquid-liquid procedure and separated on a Zorbax Eclipse XDB C(18) column with a mobile phase composed of 2 mM aqueous ammonium acetate pH 3.2 and acetonitrile (55:45). Selected reaction monitoring was performed using the transitions m/z 435 → 415 and m/z 393 → 373 to quantify triamcinolone acetonide and betamethasone, respectively...
March 2011: Journal of Mass Spectrometry: JMS
Steven D Pletcher, Andrew N Goldberg
BACKGROUND: Recurrence of sinonasal polyposis after endoscopic sinus surgery can be difficult to manage. Topical steroid sprays and irrigations may not provide adequate treatment and systemic steroid therapy is limited by side effects. This study was designed to evaluate the efficacy of steroid-infused carboxymethylcellulose (CMC) foam as a treatment for recurrence of chronic rhinosinusitis with nasal polyposis after endoscopic sinus surgery. METHODS: A prospective cohort study was performed enrolling patients with recurrent sinonasal polyposis after endoscopic sinus surgery...
November 2010: American Journal of Rhinology & Allergy
Ayse Fusun Kalpaklioglu, Ayse Baccioglu Kavut
BACKGROUND: Intranasal antihistamine has not been thoroughly studied in the treatment of rhinitis of different etiologies. This study was designed to show the comparative efficacy of nasal antihistamine and nasal corticosteroid in patients with allergic rhinitis (AR) and nonallergic rhinitis (NAR). METHODS: A comparison of the efficacy of azelastine nasal spray (AZENS) versus triamcinolone acetonide nasal spray (TANS) on total nasal symptom scores (TNSS), nasal peak inspiratory flow rate (nPIFR), and nasal cytology was studied in a 2-week randomized parallel-group trial...
January 2010: American Journal of Rhinology & Allergy
D Baumann, C Bachert, P Högger
BACKGROUND: Intranasal glucocorticoids represent the most effective pharmacologic treatment of allergic rhinitis. So far, no clinical data are available that compare fluticasone furoate (FF) with other intranasally applied glucocorticoids. OBJECTIVE: Because the pharmacokinetic behaviour of drugs governs their presence at the therapeutic target site we analysed selected in vitro properties of FF in comparison with triamcinolone acetonide (TCA), budesonide (Bud), fluticasone propionate (FP) and mometasone furoate (MF)...
October 2009: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Steven Weinstein, Paul Qaqundah, George Georges, Anjuli Nayak
BACKGROUND: Intranasal corticosteroids (INSs) are the most effective treatment for allergic rhinitis (AR). However, available INS safety and efficacy data in children younger than 6 years are limited. OBJECTIVE: To report the first well-controlled study assessing the safety and efficacy of an INS in children aged 2 to 5 years with perennial AR. METHODS: In a 4-week, multicenter, double-blind, parallel-group study, patients were randomized to receive triamcinolone acetonide aqueous nasal spray (TAA AQ), 110 microg once daily, or placebo...
April 2009: Annals of Allergy, Asthma & Immunology
David P Skoner, Deborah A Gentile, William J Doyle
BACKGROUND: Guidelines recommend treatment with intranasal corticosteroids for patients with allergic rhinitis (AR), but concerns remain about possible adverse effects. OBJECTIVE: To present the 1- and 2-year growth results for children with AR treated with triamcinolone acetonide aqueous nasal spray. METHODS: Thirty-nine children (aged 6.1-14.3 years at study entry) were treated with triamcinolone acetonide aqueous for 1 year, and a subset of 30 children completed a second year of treatment...
October 2008: Annals of Allergy, Asthma & Immunology
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