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https://www.readbyqxmd.com/read/27911446/treatment-patterns-of-ranibizumab-intravitreal-injection-and-dexamethasone-intravitreal-implant-for-retinal-vein-occlusion-in-the-usa
#1
S Nghiem-Buffet, S Baillif, S Regnier, A Skelly, N Yu, A Sodi
PurposeRanibizumab, an anti-vascular endothelial growth factor, and dexamethasone, a corticosteroid, have been shown to be effective in treating macular oedema secondary to retinal vein occlusion (RVO) (central RVO (CRVO) and branch RVO (BRVO)). Their real-world usage, however, has yet to be compared. We therefore evaluated ophthalmology visits for both drugs using US patient-level data.MethodsThe IMS Health Real-World Data Medical Claims database was used to identify treatment-naive patients receiving ranibizumab intravitreal injections or dexamethasone intravitreal implants between June 2010 and February 2014 who had 12 months of follow-up data...
December 2, 2016: Eye
https://www.readbyqxmd.com/read/27911421/-analysis-of-changes-in-central-macular-thickness-based-on-optical-coherence-tomography-angiography-findings-in-retinal-vein-occlusion
#2
M V Budzinskaya, A V Shelankova, M A Mikhailova, A A Plyukhova, N M Nurieva, A V Fomin
AIM: To investigate the relationship between OCT angiography measurements and central fundus changes in patients with retinal vein occlusion (RVO). MATERIAL AND METHODS: The study enrolled 21 RVO patients aged from 55 to 86 years (69.9±2.28 years), including 8 patients with ischemic central RVO (I-CRVO; 73.6±3.4 years on average) and 13 patients with branch RVO (BRVO; 67.6±3.0 years on average). Of the latter, 8 cases were ischemic (I-BRVO) and 5 non-ischemic (NI-BRVO)...
2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27903073/comparison-between-early-or-late-intravitreal-injection-of-dexamethasone-implant-in-branch-brvo-or-central-crvo-retinal-vein-occlusion-six-months-follow-up
#3
Fernanda Pacella, Giuseppe La Torre, Stefania Basili, Monica Autolitano, Antonella Pascarella, Tommaso Lenzi, Elena Pacella
PURPOSE: The purpose of this study was to compare early and late injections of intravitreal dexamethasone implant in patients affected by central retinal vein occlusion (CRVO) or branch retinal vein occlusion (BRVO) with a six-month follow-up. We assessed whether an earlier treatment start (within 7 days from diagnosis) could be more beneficial than a delayed (or late) treatment start (after 7 days). MATERIALS AND METHODS: The study included 81 patients (81 eyes) affected by retinal vein occlusion...
November 30, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27893623/efficacy-and-safety-of-intravitreal-conbercept-injections-in-macular-edema-secondary-to-retinal-vein-occlusion
#4
Zuhua Sun, Haiying Zhou, Bing Lin, Xuan Jiao, Yingdong Luo, Feng Zhang, Shanshan Tao, Quan Wu, Zunhong Ke, Xiaoling Liu
PURPOSE: To assess the efficacy and safety of intravitreal conbercept injections in patients with macular edema secondary to retinal vein occlusion (RVO). METHODS: A prospective, Phase II clinical trial was performed on 60 patients with macular edema secondary to RVO. Thirty patients had branch RVO (BRVO) and 30 had central RVO (CRVO). Each patient received intravitreal injections of conbercept monthly up to 3 months, followed by monthly evaluation and injection pro re nata to Month 9...
November 23, 2016: Retina
https://www.readbyqxmd.com/read/27882244/evaluation-of-peripapillary-nerve-fiber-layer-after-dexamethasone-implantation-ozurdex-in-branch-retinal-vein-occlusions
#5
Muhammed Nurullah Bulut, Yusuf Özertürk, Ümit Çallı, Güzide Akçay, Ulviye Kıvrak, Kezban Bulut
Purpose. To evaluate the peripapillary retinal nerve fiber layer (RNFL) thicknesses of patients treated with intravitreal Ozurdex implant due to branch retinal vein occlusion (BRVO) related macular edema (ME). Methods. Thirty-three eyes of 33 patients treated with Ozurdex implant due to ME associated with BRVO were included in the study. Ophthalmic examinations including determination of best corrected visual acuity (BCVA), measurement of intraocular pressure (IOP), and central macular thickness (CMT) and peripapillary RNFL assessment with optical coherence tomography (OCT) were performed before the injection of Ozurdex implant and during the 6-month follow-up period after the injection...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27872778/a-case-of-secondary-epiretinal-membrane-spontaneous-release
#6
Andrey N Andreev, Alexey V Bushuev, Sergey N Svetozarskiy
Purpose. To report a rare case of secondary epiretinal membrane (ERM) spontaneous separation with subsequent visual restoration. Case Summary. We are reporting a case with the history of branch retinal vein occlusion, peripheral retinal neovascularization, and retinal photocoagulation. Our examination revealed secondary ERM associated with relatively high visual acuity (0.6), and a watchful waiting strategy was chosen. During the follow-up, slight visual deterioration, progressive deformation of the retinal profile, and an increase in diffuse retinal edema were observed...
2016: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/27867657/method-of-quantifying-size-of-retinal-hemorrhages-in-eyes-with-branch-retinal-vein-occlusion-using-14-square-grid-interrater-and-intrarater-reliability
#7
Yuko Takashima, Masahiko Sugimoto, Kumiko Kato, Maki Kozawa, Kengo Ikesugi, Hisashi Matsubara, Mineo Kondo
Purpose. To describe a method of quantifying the size of the retinal hemorrhages in branch retinal vein occlusion (BRVO) and to determine the interrater and intrarater reliabilities of these measurements. Methods. Thirty-five fundus photographs from 35 consecutive eyes with BRVO were studied. The fundus images were analyzed with Power-Point® software, and a grid of 14 squares was laid over the fundus image. Raters were asked to judge the percentage of each of the 14 squares that was covered by the hemorrhages, and the average of the 14 squares was taken to be the relative size of the retinal hemorrhage...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27858854/prevalence-and-associated-factors-of-retinal-vein-occlusion-in-the-korean-national-health-and-nutritional-examination-survey-2008-2012-a-cross-sectional-observational-study
#8
Yong Un Shin, Heeyoon Cho, Jong Min Kim, Kunho Bae, Min Ho Kang, Jae Pil Shin, Eunwoo Nam, Se Woong Kang
Retinal vein occlusion (RVO) is the second most common retinal vascular diseases and there are only a few Asian population-based studies with small samples. Hypertension is one of a modifiable risk factor of RVO, but no recent studies have shown the relationship between RVO and hypertension control status. We aimed to investigate the prevalence of RVO and its associated factors in an adult Korean population.A nationwide population-based, cross-sectional study. We enrolled 37,982 participants from the Korea National Health and Nutrition Examination Survey who were 19 years or older and who had undergone ophthalmologic exams from 2008 through 2012...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27857739/neurodegeneration-in-branch-retinal-vein-occlusion
#9
Rayan A Alshareef, Jay Chhablani
No abstract text is available yet for this article.
September 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27847638/aflibercept-in-branch-retinal-vein-occlusion-as-second-line-therapy-clinical-outcome-12%C3%A2-months-after-changing-treatment-from-bevacizumab-ranibizumab-a-pilot-study
#10
Magdalena A Wirth, Matthias D Becker, Nicole Graf, Stephan Michels
PURPOSE: To evaluate the effect of aflibercept (as second line therapy) on the clinical outcome in patients with chronic macular edema secondary to branch retinal vein occlusion (BRVO) insufficiently responding to prior treatment with bevacizumab and/or ranibizumab. METHODS: Ten eyes of ten patients (n = 10) with chronic macular edema secondary to BRVO were included in a retrospective analysis. These patients received aflibercept after an insufficient response to treatment with ranibizumab and/- or bevacizumab...
2016: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/27847619/central-retinal-vein-occlusion-concomitant-with-dengue-fever
#11
Punithamalar Velaitham, Nandini Vijayasingham
BACKGROUND: Dengue virus infection is on the rise and there is increasing number of ocular complications that are being reported. Most common ocular complications are macular edema, macular hemorrhages, and foveolitis. There are case reports on branch retinal vessel occlusions. Most of the ocular complications are attributed to the bleeding tendency and transudative process in dengue viral infection. This is a case report of ischemic central retinal vein occlusion (CRVO) concomitant with dengue fever...
2016: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/27832655/cytokines-and-recurrence-of-macular-edema-after-intravitreal-ranibizumab-in-patients-with-branch-retinal-vein-occlusion
#12
Hidetaka Noma, Tatsuya Mimura, Kanako Yasuda, Hayate Nakagawa, Ryosuke Motohashi, Osamu Kotake, Masahiko Shimura
The aqueous humor levels of cytokines and growth/inflammatory factors were measured in 46 branch retinal vein occlusion (BRVO) patients with macular edema (ME) who were treated with intravitreal ranibizumab injection (IRI). Patients with recurrence of ME received further IRI as needed. The number of IRIs was significantly correlated with age, baseline best-corrected visual acuity, and baseline central macular thickness (CMT), as well as the baseline aqueous levels of 5 cytokines/factors (soluble vascular endothelial growth factor receptor-1, platelet-derived growth factor-AA [PDGF-AA], soluble intercellular adhesion molecule-1, interleukin-6 [IL-6], and IL-8)...
November 11, 2016: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/27832196/stromal-cell-derived-factor-1-polymorphism-in-retinal-vein-occlusion
#13
Andrea Szigeti, Mónika Ecsedy, Miklós Schneider, Lilla Lénárt, Balázs Lesch, Zoltán Zsolt Nagy, Andrea Fekete, Zsuzsanna Récsán
BACKGROUND: Stromal cell-derived factor 1 (SDF1) has crucial role in the regulation of angiogenesis and ocular neovascularisation (NV). The purpose of this study was to evaluate the association between SDF1-3'G(801)A polymorphism and NV complications of retinal vein occlusion (RVO). METHODS: 130 patients with RVO (median age: 69.0, range 35-93 years; male/female- 58/72; 55 patients had central RVO, 75 patients had branch RVO) were enrolled in this study. In the RVO group, 40 (30...
2016: PloS One
https://www.readbyqxmd.com/read/27828907/correlation-of-microvascular-structures-on-optical-coherence-tomography-angiography-with-visual-acuity-in-retinal-vein-occlusion
#14
Joon-Won Kang, Romi Yoo, Youn Hye Jo, Hyung Chan Kim
PURPOSE: To analyze the correlation of superficial and deep capillary plexuses using optical coherence tomography (OCT) angiography with visual acuity in eyes with retinal vein occlusion (RVO). METHODS: We retrospectively reviewed the medical records of 33 patients with retinal vein occlusion (RVO; branch retinal vein occlusion in 21 patients, central retinal vein occlusion in 11 patients) and included 33 healthy subjects as a control group, who were evaluated by OCT angiography...
November 8, 2016: Retina
https://www.readbyqxmd.com/read/27826179/efficacy-of-single-bevacizumab-injection-as-adjuvant-therapy-to-laser-photocoagulation-in-macular-edema-secondary-to-branch-retinal-vein-occlusion
#15
Arief S Kartasasmita, Siska Takarai, Astriviani Switania, Sutarya Enus
BACKGROUND: Macular grid laser photocoagulation remains the standard treatment for macular edema secondary to branch retinal vein occlusion (BRVO). One possible strategy for treating macular edema is to inhibit VEGF activity by competitive binding of VEGF with an anti-VEGF antibody, suggesting the therapy option with bevacizumab. However, multiple injections of anti-VEGF may lead to complications and high cost. PURPOSE: The aim of this study was to evaluate the improvement in visual acuity and central macular thickness after combination therapy of laser photocoagulation with single intravitreal bevacizumab injection in macular edema secondary to BRVO...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27796671/efficacy-of-intravitreal-bevacizumab-for-macular-edema-following-branch-retinal-vein-occlusion-stratified-by-baseline-visual-acuity
#16
Mirae Kim, Seongyong Jeong, Min Sagong
PURPOSE: To compare the clinical features and bevacizumab efficacy for macular edema (ME) following branch retinal vein occlusion (BRVO) stratified by baseline visual acuity. METHODS: This retrospective study included a total 117 eyes from 117 consecutive patients with ME following BRVO, who received PRN intravitreal bevacizumab injection and were followed for more than 6 months. The eyes were categorized into three groups according to baseline best-corrected visual acuity (BCVA) (group A, BCVA <20/200; group B, BCVA ≥20/200 and ≤20/40; group C, BCVA >20/40)...
October 29, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27793602/glaucoma-progression-in-the-unaffected-fellow-eye-of-glaucoma-patients-who-developed-unilateral-branched-retinal-vein-occlusion
#17
Hae-Young Lopilly Park, Sooji Jeon, Mee Yon Lee, Chan Kee Park
PURPOSE: To investigate glaucoma progression in eyes with glaucoma who developed unilateral branched retinal vein occlusion (BRVO) in the contralateral eye. DESIGN: Retrospective, case-control study. METHODS: Participants: Forty glaucoma patients with unilateral BRVO and 40 age- and baseline mean deviation (MD) of the visual field (VF)-matched glaucoma patients were evaluated during at least 4 years of follow-up. OBSERVATION PROCEDURES: Glaucoma progression was defined as VF progression using the modified Anderson criteria of the MD of the VF...
October 25, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27784073/retinal-hemodynamics-seen-on-optical-coherence-tomography-angiography-before-and-after-treatment-of-retinal-vein-occlusion
#18
Norihiro Suzuki, Yoshio Hirano, Taneto Tomiyasu, Yuya Esaki, Akiyoshi Uemura, Tsutomu Yasukawa, Munenori Yoshida, Yuichiro Ogura
Purpose: This study evaluates the retinal hemodynamics using optical coherence tomography angiography (OCTA) before and after anti-vascular endothelial growth factor (VEGF) therapy in patients with macular edema associated with retinal vein occlusion (RVO). Methods: Twelve patients (23 eyes; mean age, 64 years) were included (eight eyes with branch RVO, four with central RVO, and 11 unaffected fellow eyes. The best-corrected visual acuity (BCVA) and central retinal thickness (CRT) were measured before and 6 months after treatment...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27759867/optical-coherence-tomography-angiography-imaging-of-congenital-retinal-macrovessel
#19
Rohan Chawla, Ravi Bypareddy, Koushik Tripathy, Satya Sudha Daggumili, Ankit Singh Tomar
Congenital retinal macrovessels (CRM) are rarely reported, aberrant, large branches of retinal vessels that can be both arteries and veins; however, they are more commonly veins that cross the horizontal raphe to either supply or drain the macula. In this brief report, the authors discuss optical coherence tomography angiography features of CRM in a 12-year-old male patient presenting with low visual acuity in the right eye since childhood. To the authors' knowledge, this is the first such report published in the literature...
October 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/27759857/topical-squalamine-0-2-and-intravitreal-ranibizumab-0-5-mg-as-combination-therapy-for-macular-edema-due-to-branch-and-central-retinal-vein-occlusion-an-open-label-randomized-study
#20
John J Wroblewski, Allen Y Hu
BACKGROUND AND OBJECTIVE: To evaluate the effects of squalamine (OHR-102; Ohr Pharmaceuticals, New York, NY) and ranibizumab (Lucentis; Genentech, South San Francisco, CA) on macular edema (ME) secondary to retinal vein occlusion (RVO). PATIENTS AND METHODS: Twenty consecutive, treatment-naïve patients with RVO-related ME received topical squalamine and intravitreal ranibizumab 0.5 mg for 10 weeks, followed by randomization to continue or discontinue squalamine...
October 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
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