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https://www.readbyqxmd.com/read/28790803/the-outcome-of-low-frequency-intravitreal-bevacizumab-therapy-for-macular-edema-in-retinal-vein-occlusions
#1
Biljana Ivanovska Adjievska, Salih Boskurt, Nikola Orovcanec, Vesna Dimovska-Jordanova
AIM: We aimed to evaluate the 1-year efficacy and safety of low-frequency intravitreal bevacizumab in the treatment of macular edema due to retinal vein occlusions (RVOs). METHODS: The study comprised an interventional prospective study of patients with macular edema due to central retinal vein occlusion (CRVO) or branch retinal vein occlusion, followed for 12 months. Treatment-naïve patients with reduced best-corrected visual acuity (BCVA) and central macular thickness (CMT) of at least 250 μm received intravitreal injection of bevacizumab...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28781891/vascular-occlusions-following-ocular-surgical-procedures-a-clinical-observation-of-vascular-complications-after-ocular-surgery
#2
Charlotte Fischer, Anne Bruggemann, Annette Hager, Josep Callizo Planas, Johann Roider, Hans Hoerauf
BACKGROUND: Ocular vascular occlusions following intraocular procedures are a rare complication. We report a case series of patients with retinal vascular occlusions or anterior ischemic optic neuropathy (AION) after anterior and posterior segment surgery and demonstrate possible risk factors. METHODS: Observational case series. RESULTS: In ten patients, vascular occlusions were observed within ten weeks after intraocular surgery: branch retinal arterial occlusion (BRAO) (n = 2), central retinal artery occlusion (CRAO) (n = 2), central retinal vein occlusion (CRVO) (n = 1), branch retinal vein occlusion (BRVO) (n = 1), anterior ischemic optic neuropathy (AION) (n = 3), and combined central artery and vein occlusion (n = 1)...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28752913/prevalence-of-retinal-vein-occlusion-in-the-australian-national-eye-health-survey
#3
Stuart Keel, Jing Xie, Joshua Foreman, Peter van Wijngaarden, Hugh R Taylor, Mohamed Dirani
IMPORTANCE: In Australia, knowledge of the epidemiology of retinal vein occlusion (RVO) remains scarce due to a paucity of recent population-based data. The National Eye Health Survey (NEHS, 2015-16) provides an up-to-date estimate of the prevalence of RVO in non-Indigenous and Indigenous Australian adults. BACKGROUND: To determine the prevalence and associations of retinal vein occlusion (RVO) in a national sample of Indigenous and non-Indigenous Australian adults...
July 28, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28740853/prothrombotic-fibrin-clot-phenotype-in-patients-with-deep-vein-thrombosis-and-pulmonary-embolism-a-new-risk-factor-for-recurrence
#4
REVIEW
Anetta Undas
Prothrombotic fibrin clot phenotype, involving faster formation of dense meshwork composed of thinner and highly branched fibers that are relatively resistant to plasmin-induced lysis, has been reported in patients with not only myocardial infarction or stroke, but also venous thromboembolism (VTE), encompassing deep vein thrombosis (DVT), and/or pulmonary embolism (PE). Prothrombotic fibrin clot phenotype, in particular prolonged clot lysis time, is considered a novel risk factor for VTE as well as venous thrombosis at unusual location, for example, cerebral sinus venous thrombosis, retinal vein obstruction, and Budd-Chiari syndrome...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28739100/movement-of-retinal-vessels-toward-the-optic-nerve-head-after-increasing-intraocular-pressure-in-monkey-eyes-with-experimental-glaucoma
#5
Atsumi Kuroda, Nobuko Enomoto, Kyoko Ishida, Masamitsu Shimazawa, Tetsuro Noguchi, Naoto Horai, Hirotaka Onoe, Hideaki Hara, Goji Tomita
A shift or displacement of the retinal blood vessels (RBVs) with neuroretinal rim thinning indicates the progression of glaucomatous optic neuropathy. In chronic open angle glaucoma, individuals with RBV positional shifts exhibit more rapid visual field loss than those without RBV shifts. The retinal vessels reportedly move onto the optic nerve head (ONH) in response to glaucoma damage, suggesting that RBVs are pulled toward the ONH in response to increased cupping. Whether this phenomenon only applies to RVBs located in the vicinity or inside the ONH or, more generally, to RBVs also located far from the ONH, however, is unclear...
September 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28732607/refractive-outcomes-and-complications-after-combined-copolymer-phakic-intraocular-lens-explantation-and-phacoemulsification-with-intraocular-lens-implantation
#6
Paolo G Meier, François Majo, Philippe Othenin-Girard, Ciara Bergin, Ivo Guber
PURPOSE: To assess safety, efficacy, and predictability of combined Implantable Collamer Lens phakic intraocular lens (pIOL) explantation and phacoemulsification and to report the rate of complications. A secondary aim was to examine whether intraocular lens (IOL) power calculation was affected by the pIOL in situ. SETTING: Jules-Gonin Eye Hospital, Lausanne, Switzerland. DESIGN: Retrospective case series. METHODS: The records of patients having pIOL implantation with subsequent phacoemulsification were reviewed...
June 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28724817/real-world-evidence-of-safety-profile-of-intravitreal-bevacizumab-avastin-in-an-indian-scenario
#7
Prashant Jain, Jay Sheth, Giridhar Anantharaman, Mahesh Gopalakrishnan
PURPOSE: The purpose of this study was to evaluate the safety profile of intravitreal bevacizumab (Avastin) as an off-label pharmacotherapeutic agent for various ocular conditions. METHODS: Retrospective analysis was carried out on 3806 injections of 1761 patients that were administered with intravitreal bevacizumab injection at a tertiary eye care center in India. The injections were administered on a pro re nata basis for various indications such as age-related macular degeneration (AMD), diabetic macular edema (DME), and retinal vein occlusion (RVO)...
July 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28700136/an-automated-framework-to-quantify-areas-of-regional-ischemia-in-retinal-vascular-diseases-with-oct-angiography
#8
Neha Anegondi, Lavanya Chidambara, Devanshi Bhanushali, Santosh G K Gadde, Naresh Kumar Yadav, Abhijit Sinha Roy
In this observational and cross-sectional study, capillary non perfusion (CNP) and vascular changes in branch retinal vein occlusion (BRVO, sample size (n) = 26) and choroidal neovascularization (CNV, n = 29) were evaluated. Subjects underwent imaging using Optical coherence tomography angiography (Angiovue™ OCTA , RTVue XR, Optovue Inc., Fremont, CA). Local fractal analysis was applied to the OCTA images of superficial, deep and choriocapillaries layer. CNP area (BRVO eyes) and vascular parameters were computed using local fractal based method...
July 12, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28684050/thrombophilic-and-cardiovascular-risk-factors-for-retinal-vein-occlusion
#9
Paolo Bucciarelli, Serena M Passamonti, Francesca Gianniello, Andrea Artoni, Ida Martinelli
BACKGROUND: The role of thrombophilic and cardiovascular risk factors in different manifestations of retinal vein occlusion (RVO), i.e., central or branch RVO, and at different ages is still debated. AIMS: To evaluate the association between thrombophilic and cardiovascular risk factors and the risk of RVO (overall, separately for central and branch RVO, and at different ages). METHODS: Case-control study on 313 patients with a first objectively-confirmed RVO (216 central and 97 branch RVO) and 415 healthy individuals...
July 3, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28663838/retinal-oximetry-in-humans-using-visible-light-optical-coherence-tomography-invited
#10
Siyu Chen, Xiao Shu, Peter L Nesper, Wenzhong Liu, Amani A Fawzi, Hao F Zhang
We measured hemoglobin oxygen saturation (sO2) in the retinal circulation in healthy humans using visible-light optical coherence tomography (vis-OCT). The measurements showed clear oxygenation differences between central retinal arteries and veins close to the optic nerve head. Spatial variations at different vascular branching levels were also revealed. In addition, we presented theoretical and experimental results to establish that noises in OCT intensity followed Rice distribution. We used this knowledge to retrieve unbiased estimation of true OCT intensity to improve the accuracy of vis-OCT oximetry, which had inherently lower signal-to-nose ratio from human eyes due to safety and comfort limitations...
March 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28656342/effect-of-intravitreal-ranibizumab-on-the-ocular-circulation-of-the-untreated-fellow-eye
#11
Masahiko Sugimoto, Takayasu Nunome, Rie Sakamoto, Maki Kobayashi, Mineo Kondo
PURPOSE: To evaluate the effects of unilateral intravitreal ranibizumab (IVR) on the ocular circulation of the fellow eyes. METHODS: Fifteen eyes of 15 patients with macular edema (average age 69.6 ± 11.8 years) were studied. Eleven eyes had diabetic macular edema (DME) and four eyes had macular edema associated with a branch retinal vein occlusion. Each eye received 0.5 mg of IVR. The blood circulation on the optic nerve head of the treated and untreated eyes were determined by laser speckle flowgraphy (LSFG, Softcare Co...
June 28, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28646440/a-comparison-of-three-different-intravitreal-treatment-modalities-of-macular-edema-due-to-branch-retinal-vein-occlusion
#12
Havva Erdogan Kaldırım, Serpil Yazgan
PURPOSE: To compare the efficacy of intravitreal injection of ranibizumab, dexamethasone implant and aflibercept for the management of macular edema (ME) related to branch retinal vein occlusion (BRVO). METHODS: This retrospective and comparative study included 62 eyes of 62 patients with BRVO and ME. Patients received one of the following treatments: 0.5 mg ranibizumab (group 1, n = 22), 0.7 mg dexamethasone implant (group 2, n = 20) and 2 mg aflibercept (group 3, n = 20)...
June 23, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28639290/comparison-between-anti-vegf-therapy-and-corticosteroid-or-laser-therapy-for-macular-oedema-secondary-to-retinal-vein-occlusion-a-meta-analysis
#13
REVIEW
T Qian, M Zhao, X Xu
WHAT IS KNOWN AND OBJECTIVE: Therapeutic effects of anti-VEGF agents, corticosteroids and laser therapy have been previously examined for treating macular oedema secondary to branch and central retinal vein occlusion (BRVO and CRVO). However, anti-VEGF efficacy has not been previously compared to corticosteroid or laser therapy efficacy. We performed a meta-analysis to compare these treatments. METHODS: Pertinent publications were identified through comprehensive literature searches...
June 22, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28632411/the-effect-of-dexamethasone-intravitreal-implant-on-retinal-nerve-fiber-layer-in-patients-diagnosed-with-branch-retinal-vein-occlusion
#14
Orhan Ayar, Atilla Alpay, Yaran Koban, Mehmet Orcun Akdemir, Serpil Yazgan, Sılay Canturk Ugurbas, Suat Hayri Ugurbas
PURPOSE: To evaluate the effect of a single dose of intravitreal dexamethasone (DEX) implant on retinal nerve fiber layer (RNFL) thickness in patients with branch retinal vein occlusion (BRVO) in a 6-month period. MATERIALS AND METHODS: This retrospective observational study included the patients with BRVO who received intravitreal DEX implant and whose assessment included the baseline RNFL thickness measurements. The data of 26 eyes of 24 patients were retrospectively analyzed...
June 20, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28614133/time-course-of-changes-in-metamorphopsia-following-intravitreal-ranibizumab-injection-for-branch-retinal-vein-occlusion
#15
Yoshimi Sugiura, Fumiki Okamoto, Shohei Morikawa, Yoshifumi Okamoto, Takahiro Hiraoka, Tetsuro Oshika
PURPOSE: To evaluate the effects of intravitreal ranibizumab injection (IVR) on metamorphopsia in patients with branch retinal vein occlusion (BRVO) and to assess the relationship between retinal microstructure and metamorphopsia. METHODS: Subjects were 39 eyes of 39 patients with branch retinal vein occlusion. The severity of metamorphopsia was quantified using the M-CHARTS before and 1, 2, 3, 4, 5, and 6 months after treatment. Based on optical coherence tomography (OCT) images, we assessed central retinal thickness (CRT) and status of the external limiting membrane (ELM) and ellipsoid zone (EZ)...
June 13, 2017: Retina
https://www.readbyqxmd.com/read/28613352/comparison-of-ranibizumab-and-bevacizumab-for-macular-edema-secondary-to-retinal-vein-occlusions-in-routine-clinical-practice
#16
Mehnaz Khan, Karen M Wai, Fabiana Q Silva, Sunil Srivastava, Justis P Ehlers, Aleksandra Rachitskaya, Amy Babiuch, Ryan Deasy, Peter K Kaiser, Andrew P Schachat, Alex Yuan, Rishi P Singh
BACKGROUND AND OBJECTIVE: To determine outcomes of intravitreal ranibizumab (IVR) (Lucentis; Genentech, South San Francisco, CA) versus bevacizumab (IVB) (Avastin; Genentech, South San Francisco, CA) for treatment of macular edema (ME) secondary to retinal vein occlusion (RVO) in routine clinical practice. PATIENTS AND METHODS: A retrospective study identified treatment-naïve patients with ME secondary to RVO where treatment with either IVB or IVR was initiated...
June 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28610573/correlation-between-short-and-long-term-effects-of-intravitreal-ranibizumab-therapy-on-macular-edema-after-branch-retinal-vein-occlusion-a-prospective-observational-study
#17
Yoshiro Minami, Taiji Nagaoka, Akihiro Ishibazawa, Akitoshi Yoshida
BACKGROUND: The correlation between the short- and long-term effects of intravitreal ranibizumab (IVR) on macular edema after branch retinal vein occlusion (BRVO) remains unclear. We assessed the correlation between the short- and long-term effects of IVR on macular edema after BRVO. METHODS: Twenty-one eyes with macular edema after BRVO were enrolled in this prospective observational study. We measured the foveal thickness (FT) and the best-corrected visual acuity (BCVA) before, 1 day after, and 1 month after IVR (0...
June 13, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28601911/repeatability-of-ganglion-cell-inner-plexiform-layer-thickness-measurements-using-spectral-domain-oct-in-branch-retinal-vein-occlusion
#18
Yeon Hee Lee, Min-Su Kim, Seung Il Ahn, Hye Jin Park, Kyung Sup Shin, Jung-Yeul Kim
PURPOSE: To analyze the repeatability of thickness measurements of the central macula, ganglion cell-inner plexiform layer (GC-IPL), and retinal nerve fiber layer (RNFL) using spectral-domain optical coherence tomography (SD-OCT) before and after treatment of macular edema in branch retinal vein occlusion (BRVO). METHODS: We analyzed patients with BRVO who visited our retinal clinic. The repeatability of the thickness measurements were compared using the intraclass correlation coefficient (ICC) and coefficient of variation (COV) of affected versus normal fellow eyes...
June 11, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28592811/evaluating-the-impact-of-vitreomacular-adhesion-on-anti-vegf-therapy-for-retinal-vein-occlusion-using-machine-learning
#19
Sebastian M Waldstein, Alessio Montuoro, Dominika Podkowinski, Ana-Maria Philip, Bianca S Gerendas, Hrvoje Bogunovic, Ursula Schmidt-Erfurth
Vitreomacular adhesion (VMA) represents a prognostic biomarker in the management of exudative macular disease using anti-vascular endothelial growth factor (VEGF) agents. However, manual evaluation of VMA in 3D optical coherence tomography (OCT) is laborious and data on its impact on therapy of retinal vein occlusion (RVO) are limited. The aim of this study was to (1) develop a fully automated segmentation algorithm for the posterior vitreous boundary and (2) to study the effect of VMA on anti-VEGF therapy for RVO...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28559839/branch-retinal-vein-occlusion-macular-ischemia-and-intravitreal-anti-vegf-therapy
#20
Thomas Bertelmann, Hans Ulrich Frank, Hendrik Ansgar Fuchs, Nicolas Feltgen
PURPOSE: To report a case with ischemic macular edema (ME) due to an acute branch retinal vein occlusion (BRVO) which was treated with repeated intravitreal anti-VEGF injections. METHODS: Retrospective case presentation. RESULTS: A 66-year-old female patient was treated with repeated intravitreal anti-VEGF injections due to ischemic ME following an acute BRVO. Over a period of 2.5 years best corrected visual acuity increased from 0.06 to 0...
January 2017: Case Reports in Ophthalmology
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